<110> HySeq Inc.
		Tang, Tom Y.
		Zhou, Ping
		Goodrich, Ryle
		Asundi, Vinod
		Zhang, Jie
		Zhao, Qing A.
		Ren, Feiyan
		Xue, Aidong J.
		Yang, Yonghong
		Ma, Yunqing
		Yamazaki, Victoria
		Chen, Rui-hong
		Wang, Zhiwei
		Ghosh, Malabika
		Wehrman, Tom
		Wang, Jian-Rui
		Wang, Dunrui
		Drmanac, Radoje T.

<120> Novel Nucleic Acids and Polypeptides

<130> 21272-094-061

<140> not yet assigned
<141> 2002-03-14

<150> 09/810,173
<151> 2001-03-15

<160> 1052

<170> PatentIn Ver. 2.1


      <210> 1
      <211> 2816
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (228)..(2816)

      <400> 1
 aggaacacgg ttctgcctcg gaaggcgagt ttttaccatt gcaacacaaa gaacagagga     60

 gcgcgctttc acatcgttgc aacttaactc acttgaccag ctctatactt cagcaccacg    120

 gagagcggta catccttggc taccacccat ggggagccag cttctggcga ctcaacaccg    180

 gattccggtc atctagagga ggaacaagcc tgcgtattac accctca  atg ttg agg     236
                                                      Met Leu Arg
                                                        1

 aac agc acc ttc aaa aac atg cag cgc cgg cac aca acg ctg agg gag      284
 Asn Ser Thr Phe Lys Asn Met Gln Arg Arg His Thr Thr Leu Arg Glu
       5                  10                  15

 aag ggc cgt cgc cag gcc atc cgg ggt ccc gcc tac atg ttc aac gag      332
 Lys Gly Arg Arg Gln Ala Ile Arg Gly Pro Ala Tyr Met Phe Asn Glu
  20                  25                  30                  35

 aag ggc acc agt ctg acg ccc gag gag gag cgc ttc ctg gac tcg gct      380
 Lys Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu Asp Ser Ala
                  40                  45                  50

 gag tat ggc aac atc ccg gtg gtc cgg aaa atg ctg gag gag tcc aag      428
 Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu Glu Ser Lys
              55                  60                  65

 acc ctt aac ttc aac tgt gtg gac tac atg ggg cag aac gct ctg cag      476
 Thr Leu Asn Phe Asn Cys Val Asp Tyr Met Gly Gln Asn Ala Leu Gln
          70                  75                  80

 ctg gcc gtg ggc aac gag cac cta gag gtc acg gag ctg ctg ctg aag      524
 Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu Leu Leu Lys
      85                  90                  95

 aag gag aac ctg gca cgg gtg ggg gac gcg ctg ctg ctg gcc atc agc      572
 Lys Glu Asn Leu Ala Arg Val Gly Asp Ala Leu Leu Leu Ala Ile Ser
 100                 105                 110                 115

 aag ggc tat gtg cgc atc gtg gag gcc atc ctc aac cac ccg gcc ttc      620
 Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His Pro Ala Phe
                 120                 125                 130

 gcg cag ggc cag cgc ctg acg ctc agc ccg ctg gaa cag gag ctg cgc      668
 Ala Gln Gly Gln Arg Leu Thr Leu Ser Pro Leu Glu Gln Glu Leu Arg
             135                 140                 145

 gac gac gac ttc tat gcc tac gac gag gac ggc acg cgc ttc tcc cac      716
 Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg Phe Ser His
         150                 155                 160

 gac atc acg cct atc atc ctg gcg gcg cac tgc cag gag tat gag atc      764
 Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu Tyr Glu Ile
     165                 170                 175

 gtg cac atc ctg ctg ctc aag ggc gcc cgc atc gag cgg ccc cac gac      812
 Val His Ile Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg Pro His Asp
 180                 185                 190                 195

 tac ttc tgc aag tgc aat gag tgc acc gag aaa cag cgg aaa gac tcc      860
 Tyr Phe Cys Lys Cys Asn Glu Cys Thr Glu Lys Gln Arg Lys Asp Ser
                 200                 205                 210

 ttc agc cac tcg cgc tcg cgc atg aac gcc tac aaa gga ctg gcg agt      908
 Phe Ser His Ser Arg Ser Arg Met Asn Ala Tyr Lys Gly Leu Ala Ser
             215                 220                 225

 gct gcc tac ttg tcc ctg tcc agc gaa gac cct gtc ctc acc gcc ctg      956
 Ala Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu Thr Ala Leu
         230                 235                 240

 gag ctc agc aac gag tta gcc aga cta gcc aac att gag act gaa ttt     1004
 Glu Leu Ser Asn Glu Leu Ala Arg Leu Ala Asn Ile Glu Thr Glu Phe
     245                 250                 255

 aag aac gat tac agg aag tta tct atg caa tgc aag gat ttt gta gtg     1052
 Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp Phe Val Val
 260                 265                 270                 275

 ggc gtg ctg gac ctg tgc cga gac aca gaa gag gtg gaa gca att tta     1100
 Gly Val Leu Asp Leu Cys Arg Asp Thr Glu Glu Val Glu Ala Ile Leu
                 280                 285                 290

 aac ggt gat gtg aac ttc caa gtc tgg tcc gac cac cac cgt cca agt     1148
 Asn Gly Asp Val Asn Phe Gln Val Trp Ser Asp His His Arg Pro Ser
             295                 300                 305

 ctg agc cgg atc aaa ctc gcc att aaa tat gaa gtc aag aag ttc gtt     1196
 Leu Ser Arg Ile Lys Leu Ala Ile Lys Tyr Glu Val Lys Lys Phe Val
         310                 315                 320

 gct cat cct aac tgt cag cag caa ttg ctt acc atg tgg tat gaa aat     1244
 Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Met Trp Tyr Glu Asn
     325                 330                 335

 ctc tca ggc tta cgt caa cag tct atc gct gtg aaa ttc ctg gct gtc     1292
 Leu Ser Gly Leu Arg Gln Gln Ser Ile Ala Val Lys Phe Leu Ala Val
 340                 345                 350                 355

 ttt gga gtc tcc ata ggc ctc cct ttt ctc gcc ata gcc tat tgg att     1340
 Phe Gly Val Ser Ile Gly Leu Pro Phe Leu Ala Ile Ala Tyr Trp Ile
                 360                 365                 370

 gct ccg tgc agc aag cta gga cga acc ctg agg agc cct ttc atg aag     1388
 Ala Pro Cys Ser Lys Leu Gly Arg Thr Leu Arg Ser Pro Phe Met Lys
             375                 380                 385

 ttt gta gct cat gca gtt tct ttt aca atc ttc ttg gga tta tta gtt     1436
 Phe Val Ala His Ala Val Ser Phe Thr Ile Phe Leu Gly Leu Leu Val
         390                 395                 400

 gtg aat gca tct gac cga ttt gaa ggt gtt aaa acc ctg cca aac gaa     1484
 Val Asn Ala Ser Asp Arg Phe Glu Gly Val Lys Thr Leu Pro Asn Glu
     405                 410                 415

 acc ttc aca gac tac cca aaa caa atc ttc aga gtg aaa acc aca cag     1532
 Thr Phe Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys Thr Thr Gln
 420                 425                 430                 435

 ttc tcc tgg aca gaa atg ctc att atg aag tgg gtc tta gga atg att     1580
 Phe Ser Trp Thr Glu Met Leu Ile Met Lys Trp Val Leu Gly Met Ile
                 440                 445                 450

 tgg tcc gaa tgc aag gaa atc tgg gag gag ggg cca cgg gag tac gtg     1628
 Trp Ser Glu Cys Lys Glu Ile Trp Glu Glu Gly Pro Arg Glu Tyr Val
             455                 460                 465

 ctg cac ttg tgg aac ctg cta gat ttc ggg atg ctg tcc atc ttc gtg     1676
 Leu His Leu Trp Asn Leu Leu Asp Phe Gly Met Leu Ser Ile Phe Val
         470                 475                 480

 gcc tcc ttc aca gca cgc ttc atg gcc ttc ctg aag gcc acg gag gca     1724
 Ala Ser Phe Thr Ala Arg Phe Met Ala Phe Leu Lys Ala Thr Glu Ala
     485                 490                 495

 cag ctg tac gtg gac cag cac gtg cag gac gac acg ctg cac aat gtc     1772
 Gln Leu Tyr Val Asp Gln His Val Gln Asp Asp Thr Leu His Asn Val
 500                 505                 510                 515

 tcg ctt ccg ccg gaa gtg gca tac ttc acc tac gcc agg gac aag tgg     1820
 Ser Leu Pro Pro Glu Val Ala Tyr Phe Thr Tyr Ala Arg Asp Lys Trp
                 520                 525                 530

 tgg cct tca gac cct cag atc ata tcg gaa ggg ctc tac gcg ata gcc     1868
 Trp Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr Ala Ile Ala
             535                 540                 545

 gtc gtg ctg agc ttc tct cgc att gca tac att ctg cca gcc aac gag     1916
 Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro Ala Asn Glu
         550                 555                 560

 agt ttt ggg ccc ctg cag atc tcg cta ggg aga act gtg aaa gat atc     1964
 Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val Lys Asp Ile
     565                 570                 575

 ttc aag ttc atg gtc att ttc atc atg gta ttt gtg gcc ttc atg att     2012
 Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala Phe Met Ile
 580                 585                 590                 595

 ggg atg ttc aac ctg tac tct tac tac cga ggt gcc aaa tac aac cca     2060
 Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Arg Gly Ala Lys Tyr Asn Pro
                 600                 605                 610

 gcg ttt aca acg gtt gaa gaa agt ttt aaa act ttg ttt tgg tcc ata     2108
 Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe Trp Ser Ile
             615                 620                 625

 ttc ggc tta tct gaa gta atc tca gtg gtg ctg aaa tac gac cac aaa     2156
 Phe Gly Leu Ser Glu Val Ile Ser Val Val Leu Lys Tyr Asp His Lys
         630                 635                 640

 ttc atc gag aac att ggc tac gtt ctc tac ggc gtt tat aac gtc acc     2204
 Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr Asn Val Thr
     645                 650                 655

 atg gtg gta gtg ttg ctc aac atg cta ata gcc atg ata aac aac tcc     2252
 Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile Asn Asn Ser
 660                 665                 670                 675

 tat cag gaa att gag gag gat gca gat gtg gaa tgg aag ttc gcc cga     2300
 Tyr Gln Glu Ile Glu Glu Asp Ala Asp Val Glu Trp Lys Phe Ala Arg
                 680                 685                 690

 gca aaa ctc tgg ctg tct tac ttt gat gaa gga aga act cta cct gct     2348
 Ala Lys Leu Trp Leu Ser Tyr Phe Asp Glu Gly Arg Thr Leu Pro Ala
             695                 700                 705

 cct ttt aat cta gtg cca agt cct aaa tca ttt tat tat ctc ata atg     2396
 Pro Phe Asn Leu Val Pro Ser Pro Lys Ser Phe Tyr Tyr Leu Ile Met
         710                 715                 720

 aga atc aag atg tgc ctc ata aaa ctc tgc aaa tct aag gcc aaa agc     2444
 Arg Ile Lys Met Cys Leu Ile Lys Leu Cys Lys Ser Lys Ala Lys Ser
     725                 730                 735

 tgt gaa aat gac ctt gaa atg ggc atg ctg aat tcc aaa ttc aag aag     2492
 Cys Glu Asn Asp Leu Glu Met Gly Met Leu Asn Ser Lys Phe Lys Lys
 740                 745                 750                 755

 act cgc tac cag gct ggc atg agg aat tct gaa aat ctg aca gca aat     2540
 Thr Arg Tyr Gln Ala Gly Met Arg Asn Ser Glu Asn Leu Thr Ala Asn
                 760                 765                 770

 aac act ttg agc aag ccc acc aga tac cag aaa atc atg aaa cgg ctc     2588
 Asn Thr Leu Ser Lys Pro Thr Arg Tyr Gln Lys Ile Met Lys Arg Leu
             775                 780                 785

 ata aaa aga tac gtc ctg aaa gcc cag gtg gac aga gaa aat gac gaa     2636
 Ile Lys Arg Tyr Val Leu Lys Ala Gln Val Asp Arg Glu Asn Asp Glu
         790                 795                 800

 gtc aat gaa ggc gag ctg aag gaa atc aag caa gat atc tcc agc ctg     2684
 Val Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu
     805                 810                 815

 cgc tat gag ctt ctt gag gaa aaa tct caa gct act ggt gag ctg gca     2732
 Arg Tyr Glu Leu Leu Glu Glu Lys Ser Gln Ala Thr Gly Glu Leu Ala
 820                 825                 830                 835

 gac ctg att caa caa ctc agc gag aag ttt gga aag aac tta aac aaa     2780
 Asp Leu Ile Gln Gln Leu Ser Glu Lys Phe Gly Lys Asn Leu Asn Lys
                 840                 845                 850

 gac cac ctg agg gtg aac aag ggc aaa gac att tag                     2816
 Asp His Leu Arg Val Asn Lys Gly Lys Asp Ile 
             855                 860





      <210> 2
      <211> 1336
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (575)..(883)

      <400> 2
 cggacacgcg acaagggttc ctaggaataa accataaaca ggcccgggag ctacgctaac     60

 gccaaacgcc gagcagtgag acgcgcagca cccgccctgc gcctcggtgg cagccgtcca    120

 cgccgtcagt gcctggcggt tcccgtggga cataccgtcc actcgccacg cccctccgcc    180

 cgcggcgcac cccacgcacc gtgccctggc cgcccgcctc acgcaccgct ttcctctccg    240

 tccagcgctc gctgcagccg ggccgtctcg cagtccagcg tgctggccag agaccgcagc    300

 ttcccgcaga agctccggat agggtccatg ctgagcacag cggggaagga ctccaggcgt    360

 acgcagaccc caccgctcag ctcacagcct cccgccacta gtttgaatct cggcgccgga    420

 cgcgtcctcg gctctgcgca ggcgcagtcc tctctcgcga gagccgaagt ctctcgccga    480

 ggccccagga gaccccgcga gacgggtgcg cttacgccac ggcgtctgct ggcggccgcg    540

 gagacgcaga gtcttgagca gcgcggcagg cacc    atg ttc ctg act gcg ctc     592
                                          Met Phe Leu Thr Ala Leu
                                            1               5

 ctc tgg cgc ggc cgc att ccc ggc cgt cag tgg atc ggg aag cac cgg      640
 Leu Trp Arg Gly Arg Ile Pro Gly Arg Gln Trp Ile Gly Lys His Arg
              10                  15                  20

 cgg ccg cgg ttc gtg tcg ttg cgc gcc aag cag aac atg atc cgc cgc      688
 Arg Pro Arg Phe Val Ser Leu Arg Ala Lys Gln Asn Met Ile Arg Arg
          25                  30                  35

 ctg gag atc gag gcg gag aac cat tac tgg ctg agc atg ccc tac atg      736
 Leu Glu Ile Glu Ala Glu Asn His Tyr Trp Leu Ser Met Pro Tyr Met
      40                  45                  50

 acc cgg gag cag gag cgc ggc cac gcc gcg gtg cgc agg agg gag gcc      784
 Thr Arg Glu Gln Glu Arg Gly His Ala Ala Val Arg Arg Arg Glu Ala
  55                  60                  65                  70

 ttc gag gcc ata aag gcg gcc gcc act tcc aag ttc ccc ccg cat aga      832
 Phe Glu Ala Ile Lys Ala Ala Ala Thr Ser Lys Phe Pro Pro His Arg
                  75                  80                  85

 ttc att gcg gac cag ctc gac cat ctc aat gtc acc aag aaa tgg tcc      880
 Phe Ile Ala Asp Gln Leu Asp His Leu Asn Val Thr Lys Lys Trp Ser
              90                  95                 100

 taa tcct gagtcgtcac ccttggattt tatggatcac ggagctgacc atctttacct      937
 


 ggtcctggaa ctgaaaaact gtagcttgtg tgaaaatgag cctttggacc agtctttatt    997

 aaaacaaaca aacatgagta gtctgcatat cgaatatcta gagctctaaa ccccccaata   1057

 cttaaaagtc taattgctgt cctgtggttt cattagtctg ataggaagat agggatttcc   1117

 tcagtcacag atgatatttt gaaggaaagc tgcaataaag ccacaatgat ttgaggtctt   1177

 tgcttaagta tgagatactt gatgggggct ttatcatgca acattagttt gcttacctta   1237

 agaattgccc aaaaatgaaa gaaaatatga gcttttcagt taaacatact cctaaaaaca   1297

 ttttccggga ttttactact aaaattggac atttaagcg                          1336




      <210> 3
      <211> 720
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (205)..(453)

      <400> 3
 ccacgctgca ggaattcggc acgagtctca gtgtgggttg ctgaagaaat gcaggtcttt     60

 tttcttttgg aaatctccct agaatggggt caaggactct gcccattcta ggatgaaaaa    120

 ctgggatatt agacaccttc agatatttat ccccagcttt cattttgggc tcttaattag    180

 tttgttcatc catcacaatc tcaa   atg cta agc agg gca gtt gaa tct ctc     231
                              Met Leu Ser Arg Ala Val Glu Ser Leu
                                1               5

 cac agt gca aat cag cgc cgt att tta aag ttg agt ttc tta tta ttc      279
 His Ser Ala Asn Gln Arg Arg Ile Leu Lys Leu Ser Phe Leu Leu Phe
  10                  15                  20                  25

 tca cct gat gta cct tat tta tcc cac acc cac ccc aat aac ata tcg      327
 Ser Pro Asp Val Pro Tyr Leu Ser His Thr His Pro Asn Asn Ile Ser
                  30                  35                  40

 tgc tca ctg cta tct ttg agg caa ccc ttg aat ttt act cag cct gga      375
 Cys Ser Leu Leu Ser Leu Arg Gln Pro Leu Asn Phe Thr Gln Pro Gly
              45                  50                  55

 gcg ctc ttc aca tgt ctt gtc cag agc cag ttc gga ctc att ctt cag      423
 Ala Leu Phe Thr Cys Leu Val Gln Ser Gln Phe Gly Leu Ile Leu Gln
          60                  65                  70

 ccg tgc atc agt cag tgg ggg cta gct taa a ctgtggtgac aaacaacctc      474
 Pro Cys Ile Ser Gln Trp Gly Leu Ala 
      75                  80

 caaatttcag tggctcaaaa atcttcttcc tcatttattt acatctcatg actggtcagg    534

 tgagaggtag ctctgtgctg tgtcatccta acacaggaat ccagaaggaa ggagggacca    594

 tcaataagat ccccattgct atagaaaaga gaaaaaagca tgcggaatag aacgctgttt    654

 cttggagatt tctcctgaaa aagtcacatg ttatttcttc tcacctccat tggcaaaaaa    714

 aaaaaa                                                               720




      <210> 4
      <211> 1684
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (287)..(1684)

      <400> 4
 tttcgtcggg ctccggaaag ggcgggcata aggctacgga tgggcgggac ggagcagccc     60

 accgcaaagt ggcggtttac ttgaggcggt taccttagta ctccgagtag actgagtctg    120

 tggcgagctg cgggccgatt cctggccagt gccatctcag ccggagcagg cctcggggcc    180

 tcagaagcag gcttttatct ggcccgaggc tcccagccgt tcagcgcgtc ttcccataac    240

 ctataccgat tattgggact ctcggctgca gacacaggag tcacag   atg ctg gga     295
                                                      Met Leu Gly
                                                        1

 agt atg gcc cga aag aaa cct cga aat acc tca agg ttg ccc ctg gct      343
 Ser Met Ala Arg Lys Lys Pro Arg Asn Thr Ser Arg Leu Pro Leu Ala
       5                  10                  15

 tta aac ccc ctg aag agc aag gac gtg ttg gca gtg ctg gct gag agg      391
 Leu Asn Pro Leu Lys Ser Lys Asp Val Leu Ala Val Leu Ala Glu Arg
  20                  25                  30                  35

 aac gag gct ata gta cca gtt ggg gca tgg gtg gaa cct gcc tca cca      439
 Asn Glu Ala Ile Val Pro Val Gly Ala Trp Val Glu Pro Ala Ser Pro
                  40                  45                  50

 ggt agt tcg gaa atc cca gca tat aca tca gca tat tta att gaa gaa      487
 Gly Ser Ser Glu Ile Pro Ala Tyr Thr Ser Ala Tyr Leu Ile Glu Glu
              55                  60                  65

 gaa cta aag gaa cag cta aga aaa aaa caa gaa gct ttg aaa cat ttt      535
 Glu Leu Lys Glu Gln Leu Arg Lys Lys Gln Glu Ala Leu Lys His Phe
          70                  75                  80

 cag aaa caa gtt aaa tac cga gta aat caa caa att agg ttg aga aaa      583
 Gln Lys Gln Val Lys Tyr Arg Val Asn Gln Gln Ile Arg Leu Arg Lys
      85                  90                  95

 aag caa cag ctt cag aag tct tat gaa aga gca caa aaa gaa ggc tcc      631
 Lys Gln Gln Leu Gln Lys Ser Tyr Glu Arg Ala Gln Lys Glu Gly Ser
 100                 105                 110                 115

 ata gcc atg cag tct tca gca aca cac tta act tcc aaa agg aca agt      679
 Ile Ala Met Gln Ser Ser Ala Thr His Leu Thr Ser Lys Arg Thr Ser
                 120                 125                 130

 gtt ttt cca aac aat ttg aat gtt gct att gga agt tct agg tta cct      727
 Val Phe Pro Asn Asn Leu Asn Val Ala Ile Gly Ser Ser Arg Leu Pro
             135                 140                 145

 cct tcc ctg atg cct ggg gat gga ata gag gat gaa gag aat cag aac      775
 Pro Ser Leu Met Pro Gly Asp Gly Ile Glu Asp Glu Glu Asn Gln Asn
         150                 155                 160

 gaa tta ttc caa caa caa gcc cag gct ctt agt gaa act atg aaa cag      823
 Glu Leu Phe Gln Gln Gln Ala Gln Ala Leu Ser Glu Thr Met Lys Gln
     165                 170                 175

 gca cgt cac cgg cta gca tcc ttt aaa acc gtg att aaa aaa aag gga      871
 Ala Arg His Arg Leu Ala Ser Phe Lys Thr Val Ile Lys Lys Lys Gly
 180                 185                 190                 195

 tca gtg ttt cca gat gat gga agg aaa agc ttt ctt acc aga gag gaa      919
 Ser Val Phe Pro Asp Asp Gly Arg Lys Ser Phe Leu Thr Arg Glu Glu
                 200                 205                 210

 gtg ctt tcc agg aaa cca gca tcc act ggg ata aat aca gga ata aga      967
 Val Leu Ser Arg Lys Pro Ala Ser Thr Gly Ile Asn Thr Gly Ile Arg
             215                 220                 225

 gga gag ttg ccc att aag gtc cat caa ggt ctt tta gct gct gta cct     1015
 Gly Glu Leu Pro Ile Lys Val His Gln Gly Leu Leu Ala Ala Val Pro
         230                 235                 240

 tac cag aat tat atg gaa aat cag gaa ctt gac tat gag gaa cct gac     1063
 Tyr Gln Asn Tyr Met Glu Asn Gln Glu Leu Asp Tyr Glu Glu Pro Asp
     245                 250                 255

 tat gag gaa tct tca tct ctt gta act gat gag aaa ggg aaa gaa gat     1111
 Tyr Glu Glu Ser Ser Ser Leu Val Thr Asp Glu Lys Gly Lys Glu Asp
 260                 265                 270                 275

 ttg ttt ggg aga ggc cag cag gac cag cag gct atc cat tct gaa gat     1159
 Leu Phe Gly Arg Gly Gln Gln Asp Gln Gln Ala Ile His Ser Glu Asp
                 280                 285                 290

 aag aac aaa cct ttc agc aga gtt cag aaa gta aaa ttc aaa aat cca     1207
 Lys Asn Lys Pro Phe Ser Arg Val Gln Lys Val Lys Phe Lys Asn Pro
             295                 300                 305

 tta ttt gtt ctg atg gaa gag gaa gaa caa aag cag tta cat ttt gag     1255
 Leu Phe Val Leu Met Glu Glu Glu Glu Gln Lys Gln Leu His Phe Glu
         310                 315                 320

 ggc ctt cag gat att ctg cca gaa gcc cag gat tat ttt cta gaa gcc     1303
 Gly Leu Gln Asp Ile Leu Pro Glu Ala Gln Asp Tyr Phe Leu Glu Ala
     325                 330                 335

 caa ggt gat ttg ctg gaa acc cag ggt gat ttg aca gga atc cag agt     1351
 Gln Gly Asp Leu Leu Glu Thr Gln Gly Asp Leu Thr Gly Ile Gln Ser
 340                 345                 350                 355

 gtt aag cca gat acc cag gct gtt gaa atg aag gtt cag gtt act gag     1399
 Val Lys Pro Asp Thr Gln Ala Val Glu Met Lys Val Gln Val Thr Glu
                 360                 365                 370

 cca gaa ggc cag gcc att gag cca gaa ggc cag cct att agg aca gaa     1447
 Pro Glu Gly Gln Ala Ile Glu Pro Glu Gly Gln Pro Ile Arg Thr Glu
             375                 380                 385

 act cag ggt att atg ctg aaa gcc cag agt att gag cta gaa gaa ggg     1495
 Thr Gln Gly Ile Met Leu Lys Ala Gln Ser Ile Glu Leu Glu Glu Gly
         390                 395                 400

 agt att gtg ttg aaa acc cag gat ttt cta ccc aca aat cag gct ctt     1543
 Ser Ile Val Leu Lys Thr Gln Asp Phe Leu Pro Thr Asn Gln Ala Leu
     405                 410                 415

 cta acg aaa aac cag gat gtt tta ctc aaa gac cac tgt gtt ctc cct     1591
 Leu Thr Lys Asn Gln Asp Val Leu Leu Lys Asp His Cys Val Leu Pro
 420                 425                 430                 435

 aaa gac cag agt att cta ctc aaa tat cag gac cag gac ttc cca ccc     1639
 Lys Asp Gln Ser Ile Leu Leu Lys Tyr Gln Asp Gln Asp Phe Pro Pro
                 440                 445                 450

 aga gac cag cat gtt ctc cac aaa gac caa gat att ctg cca taa         1684
 Arg Asp Gln His Val Leu His Lys Asp Gln Asp Ile Leu Pro 
             455                 460                 465





      <210> 5
      <211> 1976
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(1275)

      <400> 5
 gacgaggaga atgactttcg gcaagatctg cagccaggag agcagcagtt tgcagctgac     60

 gcattaaatg ag    atg gaa gac atc gtc caa gaa gat gga gag gtg gtg     108
                  Met Glu Asp Ile Val Gln Glu Asp Gly Glu Val Val
                    1               5                  10

 gcc gag agt gga aat att act cca gcc cac agc cag gca att att cct      156
 Ala Glu Ser Gly Asn Ile Thr Pro Ala His Ser Gln Ala Ile Ile Pro
          15                  20                  25

 gtg gat gtt gat gag gaa caa gca gga ccc agt ggt ctt cag cgt gta      204
 Val Asp Val Asp Glu Glu Gln Ala Gly Pro Ser Gly Leu Gln Arg Val
      30                  35                  40

 gta aaa cca acc cca att act gtt cat gat tca gag agt gat gat gaa      252
 Val Lys Pro Thr Pro Ile Thr Val His Asp Ser Glu Ser Asp Asp Glu
  45                  50                  55                  60

 gaa gat agt cta gaa ctc caa gaa gtc tgg att cct aag aac ggt act      300
 Glu Asp Ser Leu Glu Leu Gln Glu Val Trp Ile Pro Lys Asn Gly Thr
                  65                  70                  75

 cgg cgt tac tct gaa cgt gaa gaa aaa act gga gag tca gtg cag tcc      348
 Arg Arg Tyr Ser Glu Arg Glu Glu Lys Thr Gly Glu Ser Val Gln Ser
              80                  85                  90

 aga gaa ttg tca gaa gta gcc aaa aca aag cca cgt cac gcc atg aaa      396
 Arg Glu Leu Ser Glu Val Ala Lys Thr Lys Pro Arg His Ala Met Lys
          95                 100                 105

 cgg aag cgg aca gca gat aaa tcc act agt aca agt gat cct gtg atc      444
 Arg Lys Arg Thr Ala Asp Lys Ser Thr Ser Thr Ser Asp Pro Val Ile
     110                 115                 120

 gag gat gac cat gtg cag gtt ctt gta tta aaa tcc aag aat ctt gtt      492
 Glu Asp Asp His Val Gln Val Leu Val Leu Lys Ser Lys Asn Leu Val
 125                 130                 135                 140

 gga gtc act atg acc aat tgt gga atc aca gat cta gtg cta aaa gac      540
 Gly Val Thr Met Thr Asn Cys Gly Ile Thr Asp Leu Val Leu Lys Asp
                 145                 150                 155

 tgt cca aag atg atg ttc atc cat gct acc agg tgc agg gta cta aaa      588
 Cys Pro Lys Met Met Phe Ile His Ala Thr Arg Cys Arg Val Leu Lys
             160                 165                 170

 cat tta aag gta gaa aat gca cca att gta aac cga ttt gac tat gca      636
 His Leu Lys Val Glu Asn Ala Pro Ile Val Asn Arg Phe Asp Tyr Ala
         175                 180                 185

 cag tgc aag aaa ctg aac atg gat cag gta cta gac cag ata cta aga      684
 Gln Cys Lys Lys Leu Asn Met Asp Gln Val Leu Asp Gln Ile Leu Arg
     190                 195                 200

 atg cca ccc gag aga aac cgc atc ata tac cta cgc cca atg cag cag      732
 Met Pro Pro Glu Arg Asn Arg Ile Ile Tyr Leu Arg Pro Met Gln Gln
 205                 210                 215                 220

 gtg gac act cta act ttg gag cag aag cta ttt agt ggt ccc tac ccc      780
 Val Asp Thr Leu Thr Leu Glu Gln Lys Leu Phe Ser Gly Pro Tyr Pro
                 225                 230                 235

 tat cac atc tgt att atc cat gaa ttc agt aac cct ccc aat gtc cgg      828
 Tyr His Ile Cys Ile Ile His Glu Phe Ser Asn Pro Pro Asn Val Arg
             240                 245                 250

 aat aag gtg cgc att cgc agc tgg atg gac act ata gca aac atc aat      876
 Asn Lys Val Arg Ile Arg Ser Trp Met Asp Thr Ile Ala Asn Ile Asn
         255                 260                 265

 caa gag ctc att aaa tat gaa ttc ttc cct gaa gcc act cga agt gaa      924
 Gln Glu Leu Ile Lys Tyr Glu Phe Phe Pro Glu Ala Thr Arg Ser Glu
     270                 275                 280

 gaa gac tta aag aaa tac ccc aag tac ccc tgg ggg aga gaa atc tat      972
 Glu Asp Leu Lys Lys Tyr Pro Lys Tyr Pro Trp Gly Arg Glu Ile Tyr
 285                 290                 295                 300

 act tta gaa ggt gtt gtg gat gga gct cca tat tcc atg att tct gac     1020
 Thr Leu Glu Gly Val Val Asp Gly Ala Pro Tyr Ser Met Ile Ser Asp
                 305                 310                 315

 ttc cct tgg ctg agg tca tta cga gct gca gag ccc aac agc ttc gct     1068
 Phe Pro Trp Leu Arg Ser Leu Arg Ala Ala Glu Pro Asn Ser Phe Ala
             320                 325                 330

 cga tac gac ttt gaa gac gat gaa gaa agc act atc tat gct cct aga     1116
 Arg Tyr Asp Phe Glu Asp Asp Glu Glu Ser Thr Ile Tyr Ala Pro Arg
         335                 340                 345

 agg aaa gga cag ctg tct gca gac atc tgt atg gaa aca ata gga gag     1164
 Arg Lys Gly Gln Leu Ser Ala Asp Ile Cys Met Glu Thr Ile Gly Glu
     350                 355                 360

 gaa att tca gag atg cgt cag atg aag aag ggt gta ttt cag cga gta     1212
 Glu Ile Ser Glu Met Arg Gln Met Lys Lys Gly Val Phe Gln Arg Val
 365                 370                 375                 380

 gtg gca att ttt atc cac tat tgt gat gtc aat gga gag cca gtt gaa     1260
 Val Ala Ile Phe Ile His Tyr Cys Asp Val Asn Gly Glu Pro Val Glu
                 385                 390                 395

 gat gac tac att taa ttggtccctc ctcctttcca gctattttgt cagaaagcaa     1315
 Asp Asp Tyr Ile 
             400

 gtagggccat ccagctgcca gagtgctcca cagggacttg aggcatgcag ttgggaggtc   1375

 ctggctcggt ttgctatata gggaatatat aaggaacatc gaaattgtat acaaagattt   1435

 gtacataaaa aatatacaaa gacgcttcct aaagtaccaa ctttatatca tatgtttata   1495

 caatttaatt taaaaattca ttttaaggaa gacagataat ttgaaagact tttgtttttc   1555

 ttgacttaat tcatgaagta tcattttttg actgagtctc catttacttc attcttaatg   1615

 attattgtca tccctttaaa tctgtgcctt tttcttcttg agcgaagctg tttgagtaaa   1675

 cctgttgaag agtgtttgtg tcttttgtgc ttttttgttg ttattaaaac accaactaaa   1735

 ccttatagtc aagacaaggc tctatgtttc tgtacaaagc tgtagttctt tcttagtatt   1795

 atagttgcca tgtttcttaa aatcaagtaa aaagacttat gagcttaaaa aaaagtgagt   1855

 ttgagaggga aatggaaaag tttccagagt atttctagta atttatttcc acattgaatt   1915

 gtgtatatgc tttatcttga atataaaata aaagtttatt aaaaacttta aaaaaaaaaa   1975

 a                                                                   1976




      <210> 6
      <211> 2287
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (20)..(1558)

      <400> 6
 atttgaacaa tttcagttc atg aat aaa aag aca cag cca cat cca ctg gaa      52
                      Met Asn Lys Lys Thr Gln Pro His Pro Leu Glu
                        1               5                  10

 tgg aat tct ttc aca gaa gat aag aac att gaa aaa cca caa gtg cca      100
 Trp Asn Ser Phe Thr Glu Asp Lys Asn Ile Glu Lys Pro Gln Val Pro
              15                  20                  25

 ttt gat gca ata gaa aat aaa aaa gct gga gtt cca caa att aaa aat      148
 Phe Asp Ala Ile Glu Asn Lys Lys Ala Gly Val Pro Gln Ile Lys Asn
          30                  35                  40

 gaa aat aaa gaa ata cat tgc agt gat gat gaa aac aca cca tgt cat      196
 Glu Asn Lys Glu Ile His Cys Ser Asp Asp Glu Asn Thr Pro Cys His
      45                  50                  55

 atc aag cag atc ttc aca cat cca cat ttg gaa cta aat cct gac ttt      244
 Ile Lys Gln Ile Phe Thr His Pro His Leu Glu Leu Asn Pro Asp Phe
  60                  65                  70                  75

 cat cca aag atc aaa gat tat tac tgt gaa gtc cca ttt gat gtg gta      292
 His Pro Lys Ile Lys Asp Tyr Tyr Cys Glu Val Pro Phe Asp Val Val
                  80                  85                  90

 aca gtg aca att gga gtg gaa act cct aag tgt ctg tgc aag gtg cac      340
 Thr Val Thr Ile Gly Val Glu Thr Pro Lys Cys Leu Cys Lys Val His
              95                 100                 105

 ctg tac gag cag gca ggg cca agc ttt gcc agc tac cct ctg ggc tta      388
 Leu Tyr Glu Gln Ala Gly Pro Ser Phe Ala Ser Tyr Pro Leu Gly Leu
         110                 115                 120

 gga atg aac aaa atc tca ata ttt gtt gtg gat gaa tct cca gca cac      436
 Gly Met Asn Lys Ile Ser Ile Phe Val Val Asp Glu Ser Pro Ala His
     125                 130                 135

 ggt gag act ctg atc acg tac aaa ctc acc atc tat aga gaa gac cgc      484
 Gly Glu Thr Leu Ile Thr Tyr Lys Leu Thr Ile Tyr Arg Glu Asp Arg
 140                 145                 150                 155

 cca agt ctg ccc ttg ttt gag gcc ttc aca gca tgt ggt ttt gtg cag      532
 Pro Ser Leu Pro Leu Phe Glu Ala Phe Thr Ala Cys Gly Phe Val Gln
                 160                 165                 170

 gat tgt ggt ttg ctg att cat cca gag gaa acc tgt ggg tta cag cct      580
 Asp Cys Gly Leu Leu Ile His Pro Glu Glu Thr Cys Gly Leu Gln Pro
             175                 180                 185

 att tct tct gac tac att gaa gcc att tta cag tct gaa cta aaa aga      628
 Ile Ser Ser Asp Tyr Ile Glu Ala Ile Leu Gln Ser Glu Leu Lys Arg
         190                 195                 200

 tgt cca tct ggg gac atg aaa ggc cag tgg att gtg cct tgc ctt agt      676
 Cys Pro Ser Gly Asp Met Lys Gly Gln Trp Ile Val Pro Cys Leu Ser
     205                 210                 215

 tgt tcg gac aac agg acg tgt gac tgg aga gaa ata acc tgg cag ccc      724
 Cys Ser Asp Asn Arg Thr Cys Asp Trp Arg Glu Ile Thr Trp Gln Pro
 220                 225                 230                 235

 cac aac tgc caa tat ggt gtc cta act aag cct caa ctc cag cag tgc      772
 His Asn Cys Gln Tyr Gly Val Leu Thr Lys Pro Gln Leu Gln Gln Cys
                 240                 245                 250

 ctg gga gga agg aag att ctg ttc att gga gat tca acc aac aga ggg      820
 Leu Gly Gly Arg Lys Ile Leu Phe Ile Gly Asp Ser Thr Asn Arg Gly
             255                 260                 265

 atc atg tac tat ctt att gaa agg ctg aat gaa acg ttg cag gaa tgg      868
 Ile Met Tyr Tyr Leu Ile Glu Arg Leu Asn Glu Thr Leu Gln Glu Trp
         270                 275                 280

 cag aaa gta cat ggc act aaa ttc tat cac aac gtc aat ggt ggg aag      916
 Gln Lys Val His Gly Thr Lys Phe Tyr His Asn Val Asn Gly Gly Lys
     285                 290                 295

 act ttg atc agt tat tcc tac tat ccc cag ttc tgg ata agc cct tca      964
 Thr Leu Ile Ser Tyr Ser Tyr Tyr Pro Gln Phe Trp Ile Ser Pro Ser
 300                 305                 310                 315

 ttg aga cca aca ttt gaa aat gca ctt gaa cac ctc ttg caa aga tca     1012
 Leu Arg Pro Thr Phe Glu Asn Ala Leu Glu His Leu Leu Gln Arg Ser
                 320                 325                 330

 cgt ccc cta gag aat act ggc cag act gta ttg gtt gtt ggt ggt gtt     1060
 Arg Pro Leu Glu Asn Thr Gly Gln Thr Val Leu Val Val Gly Gly Val
             335                 340                 345

 cag tgg ctt aat tcc aat cac ctg caa att att cac aaa gtt ttg aag     1108
 Gln Trp Leu Asn Ser Asn His Leu Gln Ile Ile His Lys Val Leu Lys
         350                 355                 360

 agg gaa aat tta ctc aat atc cta gtg atc atc aaa act ttg gga att     1156
 Arg Glu Asn Leu Leu Asn Ile Leu Val Ile Ile Lys Thr Leu Gly Ile
     365                 370                 375

 gga ttt cat ctg cca gtg gat gga gta cat ttc tta aca cag agt gaa     1204
 Gly Phe His Leu Pro Val Asp Gly Val His Phe Leu Thr Gln Ser Glu
 380                 385                 390                 395

 gta cag aac tta tgg aaa gaa aat ttg att att ctg gat act gca aaa     1252
 Val Gln Asn Leu Trp Lys Glu Asn Leu Ile Ile Leu Asp Thr Ala Lys
                 400                 405                 410

 aaa cat ggc tat gaa gta gtt gac aca ttc act ata aca atg ggg cgt     1300
 Lys His Gly Tyr Glu Val Val Asp Thr Phe Thr Ile Thr Met Gly Arg
             415                 420                 425

 tac aaa gag ttt cta cag ggg aag tgt gga tgt cat ttc cat gag gta     1348
 Tyr Lys Glu Phe Leu Gln Gly Lys Cys Gly Cys His Phe His Glu Val
         430                 435                 440

 gtg aaa tca aag tta tcc aaa gaa tat aac ttt att aaa atg aaa aga     1396
 Val Lys Ser Lys Leu Ser Lys Glu Tyr Asn Phe Ile Lys Met Lys Arg
     445                 450                 455

 tca aga aat cat atc atg gga aga tat ttc agc aat caa agc aaa cta     1444
 Ser Arg Asn His Ile Met Gly Arg Tyr Phe Ser Asn Gln Ser Lys Leu
 460                 465                 470                 475

 caa caa ggc act gta aca aat ttt cga tcg cca tat cat gtc aga ggt     1492
 Gln Gln Gly Thr Val Thr Asn Phe Arg Ser Pro Tyr His Val Arg Gly
                 480                 485                 490

 cca ata aat cag gtt tgt tct gaa atc ctt ctc agc agg atg tgt gca     1540
 Pro Ile Asn Gln Val Cys Ser Glu Ile Leu Leu Ser Arg Met Cys Ala
             495                 500                 505

 aat aaa agg act atg tag gctccc tgcaggagag ctgaatctgg agctggagac     1594
 Asn Lys Arg Thr Met 
         510

 gagctagtca cccggacaat ggtctaggag ccaagcgctg cacatcgcac acatttggga   1654

 tcgaccacac acacttgtgc acaccagcac atgcatgcac accagtacac acacagttaa   1714

 ataatgataa cacttcttac agctttatga attcaagatg tgaccttgaa caccagtcca   1774

 tttcacagtg aaagatatac ctagagaaac gttacttgaa gtataattat taaccagaac   1834

 cactgtgggc caggtatggc attgtgataa taaagagaaa tatagacact taaaattatg   1894

 tgaaaaaaag gataatgctc tttcatgttg tcttaccata tctataggta catcaatatt   1954

 gaaaaggaaa aaaaccaatg acattccact ggcaagtaga agttgtcctt tcattcttta   2014

 ccaggagaaa atgtgatgtt tatgatggct taggctttgt gaatctaatg cttatgaaaa   2074

 acatttcttc ctatactttt taaattttat tactgaaagg aaaagaacag gaatgttcca   2134

 caagggaatt tgaagagatt ctgtgagaga gatatgaaat attttatagt taaaacacca   2194

 atatattcaa ctttacactt cttgtgtttt tcataaacat tccctcttgt cttatctgtg   2254

 tacttcgatg ggtaactgca gtctgaatta atg                                2287




      <210> 7
      <211> 460
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (14)..(214)

      <400> 7
 gacagcggca atc   atg gcg cca cct gtg aga tac tgc atc ccc ggc gaa      49
                  Met Ala Pro Pro Val Arg Tyr Cys Ile Pro Gly Glu
                    1               5                  10

 cgt ctg tgt aac ttg gag gag ggc agc ccg ggc agc ggc acc tac acc       97
 Arg Leu Cys Asn Leu Glu Glu Gly Ser Pro Gly Ser Gly Thr Tyr Thr
          15                  20                  25

 cgc cac ggc tac atc ttt tcg tcg ctt gcc ggc tgt ctg atg aag agc      145
 Arg His Gly Tyr Ile Phe Ser Ser Leu Ala Gly Cys Leu Met Lys Ser
      30                  35                  40

 agc gag aat ggc gcg gta aag gaa gcg gca tgc cat ctc ccc tct gtt      193
 Ser Glu Asn Gly Ala Val Lys Glu Ala Ala Cys His Leu Pro Ser Val
  45                  50                  55                  60

 ttt ccc tta ggc tgc cct tga gt tccagtcctt aggcatgggc actgcggacg      246
 Phe Pro Leu Gly Cys Pro 
                  65

 cgtctttagt gcctcagtgg tacaatgttg gtctcttagt ttcttctagc cgtatcgccg    306

 ctgtggtgca cttagccacc acacactagt tgtgttgatc tcgcttggtt gtgctgctga    366

 ccctcgggga gggaagttgg gacaaaagca gatgcgaact cagtatccca tcccagccca    426

 gctcagccca gcagtgagtt gcatactgta tgaa                                460




      <210> 8
      <211> 545
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (289)..(498)

      <400> 8
 ggttccagaa gacggctgcc tccaaggggc ggctgctcag ggtccttgcg tttacagcaa     60

 catcttccca ttgaccaaat ggggacaaag agggctggag attaactgag aggtgactgt    120

 ctaggggaga ggggtcctca gatgtcctga tggctggcac aaggcggccc ttgactggag    180

 gcagatgcgt ctgccactca gagcaggcca cagggcacac cttgaggcca ggcaaggagg    240

 caagacctgg gtctccaacg ggagccaccg cctctcccac cacccagc atg ggg gcc     297
                                                      Met Gly Ala
                                                        1

 aga tca tcc ctg cgt cct cca gag aag gca acc gag cga cag cag agc      345
 Arg Ser Ser Leu Arg Pro Pro Glu Lys Ala Thr Glu Arg Gln Gln Ser
       5                  10                  15

 ttt ccc caa ctt gaa aat cac cga gca cag ata gcc atg tta cgg cca      393
 Phe Pro Gln Leu Glu Asn His Arg Ala Gln Ile Ala Met Leu Arg Pro
  20                  25                  30                  35

 ttc tgc cac ttg gcc aca gag acc agt aac ttc aat tta ttt gtg tct      441
 Phe Cys His Leu Ala Thr Glu Thr Ser Asn Phe Asn Leu Phe Val Ser
                  40                  45                  50

 ggg gcc tta agg aac ctc agc tgt cat cct ttc ctt agt tta tta cca      489
 Gly Ala Leu Arg Asn Leu Ser Cys His Pro Phe Leu Ser Leu Leu Pro
              55                  60                  65

 aat ttc taa aatatta catcctttat tatatccaaa ttcactttat tgcacttgac      545
 Asn Phe 






      <210> 9
      <211> 1762
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1008)..(1232)

      <220>
      <221> misc_feature
      <222> (1)...(1762)
      <223> n = a,t,c or g

      <400> 9
 attggagnac tcgagnccgt gcggnggaac cccccannnc tggnttttaa aatctaggna     60

 ccacttaacc ttgacaacag caccctctcc tactccagtc ctagaactca gtggccttag    120

 agaatggggt cccctgcact gaaggtcccc gccttgctcc cagttccatc ctggccaata    180

 ggctgcgcct caagaggtga aagagaaaaa agggagggag ggaggaagaa ttatttagaa    240

 caaaaggatg gctcgagcac gttagaggca agtgagaggc acgttggtga gaagagcatg    300

 tgcatgtttg gggtagctgg ggcctactgt cccttcatta gggaaggagg cttccagaag    360

 cggatgtctt ctagaaagaa aaattgtgtg aaggctgaaa aggggcttgg agttttgtct    420

 ttgttgatta gaaagaagga agaagtcagc tctgagtgtt tcaggaagaa gagagcaggt    480

 agaaagggaa tttagtgatt taacacccaa gggtccagcc atagcaggtt ggaaaatcct    540

 ccaaatttgg ccacagaagc tggctaggaa aaaactgcca ctcattgggc cacacgctgg    600

 gtccccatca gttctcaatg aatggtcatt gatttactta gcagagagaa gtcaccagcc    660

 acaaaccaat ctttgagttt gcaggccctg attccagaat atatgcatcc agctcccggg    720

 ttctcagctg gttttgccca cttccctttg actgtccaat ccaaagccag tctctcaagt    780

 tgtatggctc aaagagcagt gaccacaatg ggtcatacag tagggaccca cctccacaaa    840

 ttagaaccag agttcagact ccattgggca catctgggag gaaggcaacc tcctttgtcg    900

 tcttgttggt accagtcatt ctcaagtatc tctgacacct gtggtggttc agtttgctga    960

 gcctgccacc tggtatgaat tagattgggt gtgatgaaca ttcatcc  atg gat ata    1016
                                                      Met Asp Ile
                                                        1

 ccc tac cat ttt gcg ttg cct tat aac caa ggc aca ctc ccc ata aga     1064
 Pro Tyr His Phe Ala Leu Pro Tyr Asn Gln Gly Thr Leu Pro Ile Arg
       5                  10                  15

 gtt tac tgc aga gaa aga aca gca aaa cag cca ccc tcc ttg aat tta     1112
 Val Tyr Cys Arg Glu Arg Thr Ala Lys Gln Pro Pro Ser Leu Asn Leu
  20                  25                  30                  35

 caa ctc att atc tgc aac agg ttt tct tta aat cca aga cac agg atg     1160
 Gln Leu Ile Ile Cys Asn Arg Phe Ser Leu Asn Pro Arg His Arg Met
                  40                  45                  50

 gga aat ggg ttt ccc cac cag gta ctc aga ggt ctg cag gaa gtg act     1208
 Gly Asn Gly Phe Pro His Gln Val Leu Arg Gly Leu Gln Glu Val Thr
              55                  60                  65

 ccc ggg caa ggc aga ctt cag taa tccctgaagc gtgagcatgt ggactgcatg    1262
 Pro Gly Gln Gly Arg Leu Gln 
          70

 gctgggtggg gactggtgga tgtctctgga gctccagaac cttggagaat tcctcatgga   1322

 attcccctcc cagctcttag tgggctctgt ggggtcagga ggagcccttc ctccaggttt   1382

 tccttctttc ctcctcagca gagaaactgg agaaaggaca ttaaactcag tgcagtcgat   1442

 ttgagtgctg aaatatttcc agaatcaatg gtggtgctaa actatctcca tgtttctagc   1502

 atttttaata gtggagttgg tttgttttta atctcatcac aaaaatgcag tgcccttggg   1562

 gaagggacca gccccttggc ctgccacttt ccaggtgtcc tttatcactt tgacgggact   1622

 ctttggtctg cagaaaatgc tctgtcttgg catgcttcta gactgtaaga tttgggtttt   1682

 gttttgtatt ttatgtttac atgcatctta tatttccctg aaaactaaat aaagttttgg   1742

 gcctttttaa aaaaaaaaaa                                               1762




      <210> 10
      <211> 661
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (296)..(661)

      <400> 10
 atcatgaggg aggatgaagc tgtgaaggta ggaggctagc ttcctgtact gccattctga     60

 aaaggccttc ctagtacaca gcgcaatgct ctggtagtgt tcacatattg cctggccaaa    120

 ccaatgacca ttggaactca atttaggagg gaggctggga atattctcct atgaagatag    180

 atgaggtaga acagtgaggc tgaggagata aaaggcaaac aagggcaata gaatcctcag    240

 cctttcttgt gtgggggcac agaattaaac agtttccttt ctgtagttaa gagat atg     298
                                                              Met
                                                                1

 tgg atc att gat cca ttt gat ttt gat gag cat ttt gac aag tgc ctc      346
 Trp Ile Ile Asp Pro Phe Asp Phe Asp Glu His Phe Asp Lys Cys Leu
               5                  10                  15

 aat tat cta cca cat tac cgt acg agt gct gag ttc cac agg aca gcg      394
 Asn Tyr Leu Pro His Tyr Arg Thr Ser Ala Glu Phe His Arg Thr Ala
          20                  25                  30

 tgg atg ttg cat ttg tgt cat ctt atc cag gag gct gcc tta tac atc      442
 Trp Met Leu His Leu Cys His Leu Ile Gln Glu Ala Ala Leu Tyr Ile
      35                  40                  45

 tcc aca gtc att gag aaa ggg ggc ggc cag ctg agt cgg atc ttt atg      490
 Ser Thr Val Ile Glu Lys Gly Gly Gly Gln Leu Ser Arg Ile Phe Met
  50                  55                  60                  65

 ttt gag aaa gta agt aca agg gaa ctt gac cca tca gca tta aag ggc      538
 Phe Glu Lys Val Ser Thr Arg Glu Leu Asp Pro Ser Ala Leu Lys Gly
                  70                  75                  80

 tgc atg ttc ctc tgt gtt ttc ggc ctt cct ggt gat aag aag cca gac      586
 Cys Met Phe Leu Cys Val Phe Gly Leu Pro Gly Asp Lys Lys Pro Asp
              85                  90                  95

 gag tgt gca cat gcc ctg gag agc tcc ttc agc atc ttc agc ttc tgc      634
 Glu Cys Ala His Ala Leu Glu Ser Ser Phe Ser Ile Phe Ser Phe Cys
         100                 105                 110

 tgg gag aat ctt gct aag acc aac tga                                  661
 Trp Glu Asn Leu Ala Lys Thr Asn 
     115                 120





      <210> 11
      <211> 536
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (204)..(341)

      <400> 11
 cgcaagagtt gtgccagacc tgggcgacaa gggtgaggct cattgtactc aaaaaaaaag     60

 tccacatctt catgaaccct cagactctgg agttgggtgt cggctttttt agccagcttt    120

 tgtgggaatt gcctttgacc tattaaagaa ggaaagtggg taatggagtc ccagccactc    180

 aagagactgg atatcccccg aga    atg gct tgg gtt acc agc tat gga ccc     230
                              Met Ala Trp Val Thr Ser Tyr Gly Pro
                                1               5

 ttg gaa gat gaa tct aat cct tct cac tgg ttt ttc ttt gca aat tca      278
 Leu Glu Asp Glu Ser Asn Pro Ser His Trp Phe Phe Phe Ala Asn Ser
  10                  15                  20                  25

 ttt gct ttt att ttt cta ata aca ata aac tct att ttc cat gtt ctc      326
 Phe Ala Phe Ile Phe Leu Ile Thr Ile Asn Ser Ile Phe His Val Leu
                  30                  35                  40

 agg gcc cct ggg tag acagacacag gtttttttta aagccggcgt tgggccaaaa      381
 Arg Ala Pro Gly 
              45

 accctagcct tgagtgtcct tagtcccgac caattatttt ttttttcccc tcccaatttg    441

 aaaaaaaaat gttttttttt aggtttccaa ccctgttacc gatataaaaa aaaaaaaaac    501

 ctgttgcaaa gttctaaaaa tatatatcta tttgc                               536




      <210> 12
      <211> 782
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (208)..(549)

      <400> 12
 tttcgtcaag ggccggaagg aagccgggga gacaggtggg gtactcggga agctggagcg     60

 ggccggcggt gcagtcacgg gggagcgagg cctgctgggc ttggcaacga gggactcggc    120

 ctcggaggcg acccagacca cacagacact gggtcaagga gtaagcagag gataaacaac    180

 tggaaggaga gcaagcacaa agtcatc    atg gct tca gcg tct gct cgt gga     231
                                  Met Ala Ser Ala Ser Ala Arg Gly
                                    1               5

 aac caa gat aaa gat gcc cat ttt cca cca cca agc aag cag agc ctg      279
 Asn Gln Asp Lys Asp Ala His Phe Pro Pro Pro Ser Lys Gln Ser Leu
      10                  15                  20

 ttg ttt tgt cca aaa tca aaa ctg cac atc cac aga gca gag atc tca      327
 Leu Phe Cys Pro Lys Ser Lys Leu His Ile His Arg Ala Glu Ile Ser
  25                  30                  35                  40

 aag att atg cga gaa tgt cag gaa gaa agt ttc tgg aag aga gct ctg      375
 Lys Ile Met Arg Glu Cys Gln Glu Glu Ser Phe Trp Lys Arg Ala Leu
                  45                  50                  55

 cct ttt tct ctt gta agc atg ctt gtc acc cag gga cta gtc tac caa      423
 Pro Phe Ser Leu Val Ser Met Leu Val Thr Gln Gly Leu Val Tyr Gln
              60                  65                  70

 ggt tat ttg gca gct aat tct aga ttt gga tca ttg ccc aaa gtt gca      471
 Gly Tyr Leu Ala Ala Asn Ser Arg Phe Gly Ser Leu Pro Lys Val Ala
          75                  80                  85

 ctt gct ggt ctc ttg gga ttt ggc ctt gga aag gta tca tac ata gga      519
 Leu Ala Gly Leu Leu Gly Phe Gly Leu Gly Lys Val Ser Tyr Ile Gly
      90                  95                 100

 gta tgc cag agt aaa ttc cat ttt ttt tga a gatcagctcc gtggggctgg      570
 Val Cys Gln Ser Lys Phe His Phe Phe 
 105                 110

 ttttggtcca cagcataaca ggcactgcct ccttacctgt gaggaatgca aaataaagca    630

 tggattaagt gagaagggag actctcagcc ttcagcttcc taaattctgt gtctgtgact    690

 ttcgaagttt tttaaacctc tgaatttgta cacatttaaa atttcaagtg tactttaaaa    750

 taaaatactt ctaatggaac aaaaaaaaaa aa                                  782




      <210> 13
      <211> 660
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(613)

      <400> 13
 aaggatcctt aattaaatta atcccccccc cccccgagcg gcggctcctg cagcggtggt     60

 cggctgttgg gtgtggagtt tcccagcgcc cctcgggtcc gaccctttga gcgttctgct    120

 ccggcgccag cctacctcgc tcctcggcgc c   atg acc aca acc acc acc ttc     172
                                      Met Thr Thr Thr Thr Thr Phe
                                        1               5

 aag gga gtc gac ccc aac agc agg aat agc tcc cga gtt ttg cgg cct      220
 Lys Gly Val Asp Pro Asn Ser Arg Asn Ser Ser Arg Val Leu Arg Pro
          10                  15                  20

 cca ggt ggt gga tcc aat ttt tca tta ggt ttt gat gaa cca aca gaa      268
 Pro Gly Gly Gly Ser Asn Phe Ser Leu Gly Phe Asp Glu Pro Thr Glu
      25                  30                  35

 caa cct gtg agg aag aac aaa atg gcc tct aat atc ttt ggg aca cct      316
 Gln Pro Val Arg Lys Asn Lys Met Ala Ser Asn Ile Phe Gly Thr Pro
  40                  45                  50                  55

 gaa gaa aat caa gct tct tgg gcc aag tca gca ggt gcc aag tct agt      364
 Glu Glu Asn Gln Ala Ser Trp Ala Lys Ser Ala Gly Ala Lys Ser Ser
                  60                  65                  70

 ggt ggc agg gaa gac ttg gag tca tct gga ctg cag aga agg aac tcc      412
 Gly Gly Arg Glu Asp Leu Glu Ser Ser Gly Leu Gln Arg Arg Asn Ser
              75                  80                  85

 tct gaa gca agc tcc gga gac ttc tta gat ctg aag gga gaa ggt gat      460
 Ser Glu Ala Ser Ser Gly Asp Phe Leu Asp Leu Lys Gly Glu Gly Asp
          90                  95                 100

 att cat gaa aat gtg gac aca gac ttg cca ggc agc ctg ggg cag agt      508
 Ile His Glu Asn Val Asp Thr Asp Leu Pro Gly Ser Leu Gly Gln Ser
     105                 110                 115

 gaa gag aag ccc gtg cct gct gcg cct gtg ccc agc ccg gtg gcc cgg      556
 Glu Glu Lys Pro Val Pro Ala Ala Pro Val Pro Ser Pro Val Ala Arg
 120                 125                 130                 135

 gcc cag tgc cat cca gaa gaa tcc cct ggc ggc aag tcc agc ctc gtc      604
 Ala Gln Cys His Pro Glu Glu Ser Pro Gly Gly Lys Ser Ser Leu Val
                 140                 145                 150

 ttg ggt tag ctctgac tgtcctgaac gctgtcgttt tgtctgtttc ctccatgctt      660
 Leu Gly 






      <210> 14
      <211> 1621
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (595)..(1095)

      <400> 14
 agttggacga ggggcacttc caggttcgac tgaatcaagc atctgaagac tgggtttttt     60

 ttgttgttgt tgttcccctt acagacaaaa tgaagactat catgtgcaat cttttacagt    120

 ggggttgatg atacatttgg aaggatttgc ttgtttaata tgtacatttt ttgtgttaac    180

 agctttttga cacaattact gggtaatttc taatataggc agcagactgt tttacgggtt    240

 gctgttttaa catgggtttt tgtcagatcc atggtcttag gacttgactg atgagctttc    300

 agtgaagaat cctctaagat aaaacttcta tttaaagact ttaactagaa agtgtttatt    360

 ttggctacat tgttcacctt ctgctgtatt ggtatttgtc tgttgggatt tcaagggagt    420

 gtagagaaga cagaaggaaa gctgagagct ggcccgacat ggtctgggac acagagttgg    480

 agctggcact gaagatctcc agggacttca gagaccaata aaagcccata gggaagagag    540

 agaggatata gggaaacaga atcagatgtg taatatactt ggcacagcga aaaa  atg     597
                                                              Met
                                                                1

 gat tta aaa gac aaa aat gga ggt cca ggt aga tgt aat tca cac aga      645
 Asp Leu Lys Asp Lys Asn Gly Gly Pro Gly Arg Cys Asn Ser His Arg
               5                  10                  15

 ctg aaa gtg agt tcg ggc ttg tgt aaa aca cat gag att gga ttt gac      693
 Leu Lys Val Ser Ser Gly Leu Cys Lys Thr His Glu Ile Gly Phe Asp
          20                  25                  30

 ccc ttg gct ctc aag tgt ccc ctt aga tct aga act gct cct tgg tgg      741
 Pro Leu Ala Leu Lys Cys Pro Leu Arg Ser Arg Thr Ala Pro Trp Trp
      35                  40                  45

 cca tta gat cga gtc agt ttt gat ctg cat cac tta gtt att ggg aat      789
 Pro Leu Asp Arg Val Ser Phe Asp Leu His His Leu Val Ile Gly Asn
  50                  55                  60                  65

 ttc ttt gtt gga aac agg aaa att ttt tta gat tat ttg gtg tac ggt      837
 Phe Phe Val Gly Asn Arg Lys Ile Phe Leu Asp Tyr Leu Val Tyr Gly
                  70                  75                  80

 ttt gct cac aac aat agg tgg aag ttg cta gtg cag tct tgg tct gat      885
 Phe Ala His Asn Asn Arg Trp Lys Leu Leu Val Gln Ser Trp Ser Asp
              85                  90                  95

 ggc tgt gtg cat cgc aca ttc ggc ttg gtg aaa tcc ttc tct aaa gcc      933
 Gly Cys Val His Arg Thr Phe Gly Leu Val Lys Ser Phe Ser Lys Ala
         100                 105                 110

 tct ttt tgt att ttt ata act aaa cag agg aag tct tca gaa gac ctc      981
 Ser Phe Cys Ile Phe Ile Thr Lys Gln Arg Lys Ser Ser Glu Asp Leu
     115                 120                 125

 gct tta aaa caa att tgt gca aac act gct aga gtc att ttg aag ctc     1029
 Ala Leu Lys Gln Ile Cys Ala Asn Thr Ala Arg Val Ile Leu Lys Leu
 130                 135                 140                 145

 aag cat ttt cac ttt gtt tct tac atg tgt act ttt ttg ttt act tgt     1077
 Lys His Phe His Phe Val Ser Tyr Met Cys Thr Phe Leu Phe Thr Cys
                 150                 155                 160

 gaa aat ggc cat ctt taa gcatat ttattttctg ccactttatt taaaggcaag     1131
 Glu Asn Gly His Leu 
             165

 caatattttc ttgatcataa atattttgta atgaaatact tcctcttttc cagggctttg   1191

 tatgcacttg tataattaca ttgatggcaa tgtagagttt gaatttcagt ctgtaaatac   1251

 ttttttggaa aatagaaatt tttattgctt taaagttttg gatatgggtg gttttctttt   1311

 ccgggtttgg tggaaagtaa tttgagaact ttaaggttgt ctttttaact gctggcaaaa   1371

 tgttgatttt ttaatattag ataaaacgag taaacgaaat tccccagaaa ttagtagtaa   1431

 gtggggtctt tgtgggttgg gaagtagttt taatgtagaa agacatttac atataagtct   1491

 gtttaatttc aaaggagttt gtgaaaaaaa atccatggtg aaaatgaaac aatgacatgg   1551

 ttaatctgga acttacgttc ttataccaat aaaaggtacc tcaatacatg ttctttcaaa   1611

 aaaaaaaaaa                                                          1621




      <210> 15
      <211> 1016
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(969)

      <400> 15
  atg gca gga att ggt gac cta ctg gat gct gtg acc gag gcc gga gcc      48
  Met Ala Gly Ile Gly Asp Leu Leu Asp Ala Val Thr Glu Ala Gly Ala
    1               5                  10                  15

 gcg att ggt ggg cat ttg ccg gcg gcc acc gct ttt aag cca cga ttg       96
 Ala Ile Gly Gly His Leu Pro Ala Ala Thr Ala Phe Lys Pro Arg Leu
              20                  25                  30

 gcg aag gcc gcc gtc att tcg gag cga ctc agc gcc tgc ccg ccc tct      144
 Ala Lys Ala Ala Val Ile Ser Glu Arg Leu Ser Ala Cys Pro Pro Ser
          35                  40                  45

 cgc cgc gtc gcc ggt gcc tgc gcc tcc cgc tcc acc tcg ctt ctt ctc      192
 Arg Arg Val Ala Gly Ala Cys Ala Ser Arg Ser Thr Ser Leu Leu Leu
      50                  55                  60

 tcc cgg ccg agg ccc ggg gga cca gag cga gaa gcg ggg acc atg ttc      240
 Ser Arg Pro Arg Pro Gly Gly Pro Glu Arg Glu Ala Gly Thr Met Phe
  65                  70                  75                  80

 cga cgc aag ttg acg gct ctc gac tac cac aac ccc gcc ggc ttc aac      288
 Arg Arg Lys Leu Thr Ala Leu Asp Tyr His Asn Pro Ala Gly Phe Asn
                  85                  90                  95

 tgc aaa gat gaa aca gaa ttt aga aac ttc atc gtt tgg ctt gaa gac      336
 Cys Lys Asp Glu Thr Glu Phe Arg Asn Phe Ile Val Trp Leu Glu Asp
             100                 105                 110

 cag aaa atc agg cac tac aag att gaa gac aga ggg aat tta aga aac      384
 Gln Lys Ile Arg His Tyr Lys Ile Glu Asp Arg Gly Asn Leu Arg Asn
         115                 120                 125

 atc cac agc agc gac tgg ccc aag ttc ttt gaa aag tat ctc aga gat      432
 Ile His Ser Ser Asp Trp Pro Lys Phe Phe Glu Lys Tyr Leu Arg Asp
     130                 135                 140

 gtt aac tgt cct ttc aag att caa gat cga caa gaa gct att gac tgg      480
 Val Asn Cys Pro Phe Lys Ile Gln Asp Arg Gln Glu Ala Ile Asp Trp
 145                 150                 155                 160

 ctt ctt ggt tta gct gtt aga ctt gaa tat gga gat aat gct gaa aaa      528
 Leu Leu Gly Leu Ala Val Arg Leu Glu Tyr Gly Asp Asn Ala Glu Lys
                 165                 170                 175

 tac aag gat tta gta cct gat aat tca aaa act gct gac aat gca act      576
 Tyr Lys Asp Leu Val Pro Asp Asn Ser Lys Thr Ala Asp Asn Ala Thr
             180                 185                 190

 aaa aat gca gaa cca ttg atc aat ttg gat gta aat aat cct gat ttt      624
 Lys Asn Ala Glu Pro Leu Ile Asn Leu Asp Val Asn Asn Pro Asp Phe
         195                 200                 205

 aag gct ggt gtg atg gct ttg gct aac ctg ctt cag att cag cgt cat      672
 Lys Ala Gly Val Met Ala Leu Ala Asn Leu Leu Gln Ile Gln Arg His
     210                 215                 220

 gat gat tac ctg gta atg ctt aag gca att cgg att ttg gtt cag gag      720
 Asp Asp Tyr Leu Val Met Leu Lys Ala Ile Arg Ile Leu Val Gln Glu
 225                 230                 235                 240

 cgc ctg aca cag gat gca gtt gct aag gca aat caa aca aaa gag ggc      768
 Arg Leu Thr Gln Asp Ala Val Ala Lys Ala Asn Gln Thr Lys Glu Gly
                 245                 250                 255

 tta cct gtt gct tta gac aaa cat att ctt ggt ttt gac aca gga gat      816
 Leu Pro Val Ala Leu Asp Lys His Ile Leu Gly Phe Asp Thr Gly Asp
             260                 265                 270

 gca gtt ctt aat gaa gct gct caa att ctg cga ttg ctg cac ata gag      864
 Ala Val Leu Asn Glu Ala Ala Gln Ile Leu Arg Leu Leu His Ile Glu
         275                 280                 285

 gag ctc aga gag cta cag aca aaa atc aac gaa gcc ata gta gct gtt      912
 Glu Leu Arg Glu Leu Gln Thr Lys Ile Asn Glu Ala Ile Val Ala Val
     290                 295                 300

 cag gca att att gct gat cca aag aca gac cac aga ctg gga aaa gtt      960
 Gln Ala Ile Ile Ala Asp Pro Lys Thr Asp His Arg Leu Gly Lys Val
 305                 310                 315                 320

 gga aga tga acacttg aggacttcag cttctcacct actttagtac agttgggaac     1016
 Gly Arg 






      <210> 16
      <211> 2087
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (364)..(1344)

      <400> 16
 ctagccaaca gcaacgccgg cgccgccgtg ggcaggaagg ccgggccgcg cagcccgccc     60

 agcgcccccg cgccagcgcc gccgccgccc gcgcccgcgc cgcccacact cggcaacaac    120

 caccaggaga gccccggctg gcggtgctgc cgccccacgc tgcgcgagag gtgagcccgt    180

 gccccgcggc ccccgcgccc gcgcgcgccc acgcccccag cccgtgcctc tacctttgca    240

 ggaacgcgct catgttcaac aacgagctca tggccgacgt gcacttcgtc gtggggcccc    300

 cgggggcgac caggacggtg cccgcccaca agtacgtctt ggctgtcggc agctccgtct    360

 tct  atg cca tgt tct acg gag acc tgg cgg aag tca aat ctg aaa ttc     408
      Met Pro Cys Ser Thr Glu Thr Trp Arg Lys Ser Asn Leu Lys Phe
        1               5                  10                  15

 aca ttc cag acg tgg agc ccg cag cct tct gat cct ctt aaa gta agt      456
 Thr Phe Gln Thr Trp Ser Pro Gln Pro Ser Asp Pro Leu Lys Val Ser
                  20                  25                  30

 cca ctc tac tgg gga ggg acg ggt ggg tcc gtt tta ggc ggc ctc cgg      504
 Pro Leu Tyr Trp Gly Gly Thr Gly Gly Ser Val Leu Gly Gly Leu Arg
              35                  40                  45

 agg ctt ctg aag gga agc aca cag gag ctg atg gac tcc tct ccc agg      552
 Arg Leu Leu Lys Gly Ser Thr Gln Glu Leu Met Asp Ser Ser Pro Arg
          50                  55                  60

 ccc agc ccc gcg atg ggt gct tgg gga gcc agc cct gac gcg ggc cct      600
 Pro Ser Pro Ala Met Gly Ala Trp Gly Ala Ser Pro Asp Ala Gly Pro
      65                  70                  75

 gcc tcg cct agg tac atg tac agt gtg gag atg aga tcg atc tgg aag      648
 Ala Ser Pro Arg Tyr Met Tyr Ser Val Glu Met Arg Ser Ile Trp Lys
  80                  85                  90                  95

 ccg aca cgg tgc tgg aca ctc tgt atg ctg cta aga agt aca tcg tcc      696
 Pro Thr Arg Cys Trp Thr Leu Cys Met Leu Leu Arg Ser Thr Ser Ser
                 100                 105                 110

 cag cat tgg caa aag cct gtg tca act ttc tgg aga caa gtt tgg aag      744
 Gln His Trp Gln Lys Pro Val Ser Thr Phe Trp Arg Gln Val Trp Lys
             115                 120                 125

 cca aga acg act gcg tcc tgc tgt ccc aga gcc ggc tgt ttg agg agc      792
 Pro Arg Thr Thr Ala Ser Cys Cys Pro Arg Ala Gly Cys Leu Arg Ser
         130                 135                 140

 ccg agc tgg acg cag cgc tgc tgg gag gtc att gac gca cag gcc gag      840
 Pro Ser Trp Thr Gln Arg Cys Trp Glu Val Ile Asp Ala Gln Ala Glu
     145                 150                 155

 atg gcc cta cgg tcc gaa ggc ttc tgt gag ata gac cgg cag acg ctg      888
 Met Ala Leu Arg Ser Glu Gly Phe Cys Glu Ile Asp Arg Gln Thr Leu
 160                 165                 170                 175

 gag atc att gtc act cgg gag gcc ctc aac acc aaa gag gcg gtg gtc      936
 Glu Ile Ile Val Thr Arg Glu Ala Leu Asn Thr Lys Glu Ala Val Val
                 180                 185                 190

 ttc gag gcc gtc ctg aac tgg gcc gag gcg gag tgc aag agg cag ggg      984
 Phe Glu Ala Val Leu Asn Trp Ala Glu Ala Glu Cys Lys Arg Gln Gly
             195                 200                 205

 ctg cca atc acc cca cga aac aag agg cat gtt ctg ggg cga gcc ctc     1032
 Leu Pro Ile Thr Pro Arg Asn Lys Arg His Val Leu Gly Arg Ala Leu
         210                 215                 220

 tat ctg gtc cgg aat tcc aac cat gac cct aga gga gtt tgc caa cgg     1080
 Tyr Leu Val Arg Asn Ser Asn His Asp Pro Arg Gly Val Cys Gln Arg
     225                 230                 235

 cgc tgc cca gtc aga cat cct gac tct gga gga gac cca cag cat ctt     1128
 Arg Cys Pro Val Arg His Pro Asp Ser Gly Gly Asp Pro Gln His Leu
 240                 245                 250                 255

 cct gtg gta cac ggc cac caa caa gcc ccg cct gga ctt tcc cct gac     1176
 Pro Val Val His Gly His Gln Gln Ala Pro Pro Gly Leu Ser Pro Asp
                 260                 265                 270

 caa gag gaa ggg cct cgc ccc gca gag gtg cca ccg att cca gtc ttc     1224
 Gln Glu Glu Gly Pro Arg Pro Ala Glu Val Pro Pro Ile Pro Val Phe
             275                 280                 285

 tgc cta ccg cag caa cca gtg gcg gta ccg cgg gcg ctg cga cag cat     1272
 Cys Leu Pro Gln Gln Pro Val Ala Val Pro Arg Ala Leu Arg Gln His
         290                 295                 300

 cca gtt tgc agt gga cag aag ggt att tat tgc agg gct ggg cct gta     1320
 Pro Val Cys Ser Gly Gln Lys Gly Ile Tyr Cys Arg Ala Gly Pro Val
     305                 310                 315

 tgg ctc cag ctc tgg gaa ggc tga gtacagcgtg aagattgagc tcaagcggct    1374
 Trp Leu Gln Leu Trp Glu Gly 
 320                 325

 cggggtggtt ctggctcaga acttgaccaa gttcatgtca gacggatcca gtaacacctt   1434

 cccggtctgg tttgaacacc cggtccaggt tgaacaagac accttctaca cggccagtgc   1494

 cgtcctggac ggcagcgaac tcagctactt tgggcaggag gggatgacgg aagtgcagtg   1554

 tggaaaggtg gccttccagt tccagtgctc cctcggacag caccaacggg actggggtcc   1614

 agggtgggca gatccctgag ctcattttct atgcctgagg tgcccgggga ggctgcagca   1674

 ggtcagcgag tgagtggagg ggaagtcaag atgctaactg cttcttgaca ccatgaaagg   1734

 ctgctcttaa ctttgtctct ctttgacatg tagtcagctg aagcttgact gtgtagagac   1794

 attttccaca cagccagaac ccagggattg gagtcttagg catctctggt acagtggggt   1854

 gcacgtctca ggtggaggaa gatttacggc tcaagacagg ccccagatcc cctcccagtg   1914

 gcacccacgc cacctgcttt gaggggttgg atcttcctgc taccctcttg gattctaagt   1974

 ggttccaagc ttaacttgag accttccctt caaatctaaa attggcaaaa agtcacttaa   2034

 aatagtggac ttctgtaata aaggttgcct aaaataacaa aaaaaaaaaa aaa          2087




      <210> 17
      <211> 1237
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (866)..(1186)

      <400> 17
 ccgggtcatg cctggctttc tggggactcc agccggaata actaccacat cacaaccttt     60

 caggcagtca ggcagctgtt caggtccgag gtagcctttc acagcggctt ttactctaaa    120

 cagcaacaca gacaaaacgc catataaaca caaaggaagt ggcgcagaac cgagatgctg    180

 acctggggtc tgaggctcaa aagcagcaca gcccaggttc tagaaggttc tagagaggag    240

 cggcaggagg gagcaaactt cttggcttgt gctcggaccc ttttctcgta ctccactctg    300

 ttttggcagt aaatcgtgta ggcctctgct tgagctgggt cttggatatt tggttcattt    360

 agaagttcct gtattcctaa taggatctgt ttgattgtga tggctggcct ccagtccttg    420

 tcctcctcta agaaggaaaa ggcaactggc ccccgaggta acacaattcg gggggaaata    480

 atggtggtcc gaatttacat tttggtggcg aagatggata atcatctttg aaaagcatcc    540

 gtagtttaaa caagcctcct tcccacggag tccctttctt tcctggaatg gcgcactccc    600

 agttcatgag gttcatcgtg ccatcgggat tttttgttgg gacagccacg aaaccaaatg    660

 ggtggtcttt cctccatgct ttcctctcct gggcgagtct gctgagggcg atccccgaca    720

 tgttcaaagt ccctcgggcg gccgcagccc cggcgagcgt agcggacagg tggaggaccg    780

 agcggggcgg cggcggcggc gcttcccttt gtctcgggac ttccctccgg agcccgctcc    840

 gcgcgcagcc agagggactt tgaac  atg tcg ggg atc gcc ctc agc aga ctc     892
                              Met Ser Gly Ile Ala Leu Ser Arg Leu
                                1               5

 gcc cag gag agg aaa gca tgg agg aaa gac cac cca ttt ggt ttc gtg      940
 Ala Gln Glu Arg Lys Ala Trp Arg Lys Asp His Pro Phe Gly Phe Val
  10                  15                  20                  25

 gct gtc cca aca aaa aat ccc gat ggc acg atg aac ctc atg aac tgg      988
 Ala Val Pro Thr Lys Asn Pro Asp Gly Thr Met Asn Leu Met Asn Trp
                  30                  35                  40

 gag tgc gcc att cca gga aag aaa ggg gta agg ggc gct gcg gcc tcc     1036
 Glu Cys Ala Ile Pro Gly Lys Lys Gly Val Arg Gly Ala Ala Ala Ser
              45                  50                  55

 tgc ctg tcg ggg ctc agc aga tgc gtg cgg cag tgc cat ggg gat act     1084
 Cys Leu Ser Gly Leu Ser Arg Cys Val Arg Gln Cys His Gly Asp Thr
          60                  65                  70

 ccg ctc aga tcc ctg ccg tcc gtg acg cag ccc ttg tca cag gcc gcg     1132
 Pro Leu Arg Ser Leu Pro Ser Val Thr Gln Pro Leu Ser Gln Ala Ala
      75                  80                  85

 gtc aac agc tca gat ccc cag ctg tgg cct ggc ccc cgc ccc gtg aga     1180
 Val Asn Ser Ser Asp Pro Gln Leu Trp Pro Gly Pro Arg Pro Val Arg
  90                  95                 100                 105

 act tga gctcagaagg tggtgctggc aaggttgggg tgacagctgt gtccctaccg      1236
 Thr 


 a                                                                   1237




      <210> 18
      <211> 1401
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (19)..(699)

      <400> 18
 gacgcagagg cggacaag  atg gcg gcg gca gct gta cag ggc ggg aga agc      51
                      Met Ala Ala Ala Ala Val Gln Gly Gly Arg Ser
                        1               5                  10

 ggt ggt agc gga ggc tgt agt ggg gct ggt ggt gct tcc aac tgc ggg       99
 Gly Gly Ser Gly Gly Cys Ser Gly Ala Gly Gly Ala Ser Asn Cys Gly
              15                  20                  25

 aca gga agt ggc cgt agc ggc ttg ttg gat aag tgg aag ata gat gat      147
 Thr Gly Ser Gly Arg Ser Gly Leu Leu Asp Lys Trp Lys Ile Asp Asp
          30                  35                  40

 aag cct gta aaa att gac aag tgg gat gga tca gct gtg aaa aac tct      195
 Lys Pro Val Lys Ile Asp Lys Trp Asp Gly Ser Ala Val Lys Asn Ser
      45                  50                  55

 ttg gat gat tct gcc aaa aag gta ctt ctg gaa aaa tac aaa tat gtg      243
 Leu Asp Asp Ser Ala Lys Lys Val Leu Leu Glu Lys Tyr Lys Tyr Val
  60                  65                  70                  75

 gag aat ttt ggt cta att gat ggt cgc ctc acc atc tgt aca atc tcc      291
 Glu Asn Phe Gly Leu Ile Asp Gly Arg Leu Thr Ile Cys Thr Ile Ser
                  80                  85                  90

 tgt ttc ttt gcc ata gtg gct ttg att tgg gat tat atg cac ccc ttt      339
 Cys Phe Phe Ala Ile Val Ala Leu Ile Trp Asp Tyr Met His Pro Phe
              95                 100                 105

 cca gag tcc aaa ccc gtt ttg gct ttg tgt gtc ata tcc tat ttt gtg      387
 Pro Glu Ser Lys Pro Val Leu Ala Leu Cys Val Ile Ser Tyr Phe Val
         110                 115                 120

 atg atg ggg att ctg acc att tat acc tca tat aag gag aag agc atc      435
 Met Met Gly Ile Leu Thr Ile Tyr Thr Ser Tyr Lys Glu Lys Ser Ile
     125                 130                 135

 ttt ctc gtg gcc cac agg aaa gat cct aca gga atg gat cct gat gat      483
 Phe Leu Val Ala His Arg Lys Asp Pro Thr Gly Met Asp Pro Asp Asp
 140                 145                 150                 155

 att tgg cag ctg tcc tcc agt ctt aaa agg ttt gat gac aaa tac acc      531
 Ile Trp Gln Leu Ser Ser Ser Leu Lys Arg Phe Asp Asp Lys Tyr Thr
                 160                 165                 170

 ttg aag ctg acc ttc atc agt ggg aga aca aag cag cag cgg gaa gcc      579
 Leu Lys Leu Thr Phe Ile Ser Gly Arg Thr Lys Gln Gln Arg Glu Ala
             175                 180                 185

 gag ttc aca aag tcc att gct aag ttt ttt gac cac agt ggg aca ctg      627
 Glu Phe Thr Lys Ser Ile Ala Lys Phe Phe Asp His Ser Gly Thr Leu
         190                 195                 200

 gtc atg gat gca tat gag cct gaa ata tcc agg ctc cat gac agt ctt      675
 Val Met Asp Ala Tyr Glu Pro Glu Ile Ser Arg Leu His Asp Ser Leu
     205                 210                 215

 gcc ata gaa aga aaa ata aag tag ccaattctaa aagtagccct ctttctcctg     729
 Ala Ile Glu Arg Lys Ile Lys 
 220                 225

 gatcttgctg aattagtggc ttggggggtg ggggagataa aaagaactta aaatgggtaa    789

 agtaagaaat gttaaaaagt ccctgttttg tcctgaaatt ttagtctatt ctgggtaaat    849

 aggattttct gacacagata tgagaagttg tagctctgat gtctagctgt agtctccttg    909

 atctgctgat tgcattattt taatttgctt ttctgggaaa gcagttttgc taaaagctgt    969

 acagactttt tcttttgtac ctagcagtac tttatatagt atagctttgg gccatgtagc   1029

 attttaagac tcaattttaa aaaattatta atctgttgct gactcttaat tcctatttca   1089

 atatgtgttt ccttgaagaa ttcaggatac aacttcttgt gtatgacagc tttccttcac   1149

 acactatttt tgtgggtgtg tatatatctg atttgggaag aatttaaaaa acacatagct   1209

 ttttaatttg tttgaaacag actttctgcc tgttacattt ttgcttttaa ccaattaaag   1269

 aagccaatgg cattttagtt ttatattgtg ttttccacta gtatatccct gttgatttgt   1329

 ttgtgccttt tattaactgc cattttctaa aatttttttc aataaaagga aggaagatgt   1389

 gaaaaaaaaa aa                                                       1401




      <210> 19
      <211> 690
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (190)..(543)

      <400> 19
 atgcgcggag agagcagcct gggcgccgag gcagcggggt gctcggttcc cggagtgatg     60

 gcggatgagg ctgcctgtga gcgtgtccga ggcaaggatc cttaattaaa ttaatccccc    120

 ccccccgact tccggaacaa gcgtcgcgtt tctgaggaga aactcttggt gagaattccc    180

 agagtgata    atg gct acc tac agc ctg gcg aac gag aga cta cgc gct     228
              Met Ala Thr Tyr Ser Leu Ala Asn Glu Arg Leu Arg Ala
                1               5                  10

 ctg gaa gac att gaa cgg gaa atc ggc gcc atc ctt cag aat gca ggt      276
 Leu Glu Asp Ile Glu Arg Glu Ile Gly Ala Ile Leu Gln Asn Ala Gly
      15                  20                  25

 act gtg atc cta gaa ttg tcc aag gaa aaa act aac gag cgg ctc cta      324
 Thr Val Ile Leu Glu Leu Ser Lys Glu Lys Thr Asn Glu Arg Leu Leu
  30                  35                  40                  45

 gac cgg cag gcg gcg gcc ttc acc gct tca gtg caa cac gtg gag gcg      372
 Asp Arg Gln Ala Ala Ala Phe Thr Ala Ser Val Gln His Val Glu Ala
                  50                  55                  60

 gag ctg tca gct cag atc cgc tac ctc acc cag gtg gcc aca ggg cag      420
 Glu Leu Ser Ala Gln Ile Arg Tyr Leu Thr Gln Val Ala Thr Gly Gln
              65                  70                  75

 ccc cat gag ggc tcc agc tac tct tcg agg aag gac tgt cag atg gct      468
 Pro His Glu Gly Ser Ser Tyr Ser Ser Arg Lys Asp Cys Gln Met Ala
          80                  85                  90

 ctg aag cga gtg gac tat gcc cgc ctc aag ctc agt gat gtg gct cga      516
 Leu Lys Arg Val Asp Tyr Ala Arg Leu Lys Leu Ser Asp Val Ala Arg
      95                 100                 105

 acc tgt gag cag atg ctg gag aac tag gccag ggagatggac ccagagctga      568
 Thr Cys Glu Gln Met Leu Glu Asn 
 110                 115

 gagggagacc atcacctgtg ccatgggaca gaacctggga acatgtaggg tggggagtat    628

 gagcaccaac ataccctgct ggtcaaagta ccctaggaca aaggggcaaa tggtgggcat    688

 gg                                                                   690




      <210> 20
      <211> 5719
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1438)..(4341)

      <400> 20
 tttgccgata ccttaggata caacatagaa cctattatgc tctatcagga tatgacagcg     60

 cgtgatctgc tacagcagag atacaccctt ccaaatggag acactgcctg gcggtcctca    120

 ccccttgtga atgctgctct ggaaggcaag ctggtcctgc tggatggcat tcaccgggtg    180

 aatgcgggca cgcttgctgt attgcaaagg ttaatccatg atcgagagct aagcctctat    240

 gatggttcta ggctgctgag agaagacagg tatatgcgtt taaaggagga gctgcaactg    300

 tctgatgaac agctacagaa gagatccatt tttcctatcc atccctcctt cagaatcatt    360

 gccttggcag aaccccctgt tattggaagc acagcacacc agtggctggg accagaattc    420

 ttaaccatgt tctttttcca ttacatgaaa ccacttgtga aaagtgaaga aatccaagtg    480

 attaaggaaa aggtcccaaa tgtacctcag gaagctctgg ataagttatt atcatttaca    540

 cacaaactca gagaaacaca ggatccaacg gcacaatcat tagcggcatc actttctacc    600

 agacaactgt tgcgaatttc tcgtcggctg tcacagtatc ctaatgaaaa tcttcacagt    660

 gctgttacta aagcctgcct ttccaggttt ttacccagtc ttgctaggtc agcattagaa    720

 aaaatctggc agatgctaca atagaaataa atactgatga caatttggag ccagaactga    780

 aggattacaa atgtgaagta acatctggaa ctctgaggat tggtgctgtt agtgcaccga    840

 tctataatgc acatgagaaa atgaaagtgc ctgatgttct tttctatgac aacattcagc    900

 atgtgatagt gatggaagat atgctgaaag actttctcct tggagaacac ttattattgg    960

 ttggcaacca gggtgtagga aaaaacaaga ttgttgacag attccttcac ctgctcaaca   1020

 gaccccgaga atatattcag ctacacaggg ataccacagt acaaactctt acgcttcagc   1080

 cttcggttaa agacggactt attgtatatg aagactcacc tttggttaaa gcagtaaagt   1140

 tgggtcatat tctggtagta gatgaggctg acaaagctcc aacaaatgtc acgtgtattt   1200

 taaaaactct agtagaaaat ggagaaatga ttctagcaga tggaagacgc attgttgcaa   1260

 attctgctaa tgtgaatgga agagaaaatg ttgtagtgat tcatcctgat tttaggatga   1320

 ttgttctggc aaatagacct ggatttcctt tcctaggcaa tgatttcttc ggtaccttag   1380

 gtgatatttt ttagctgcca tgcagttgat aaccccaaac cccactcgga gctcgag      1437                                                                 
 atg ctc aga cag tat gga cca aat gtg cct gag ccc atc ctt cag aag     1485
 Met Leu Arg Gln Tyr Gly Pro Asn Val Pro Glu Pro Ile Leu Gln Lys
   1               5                  10                  15

 ctt gtg gct gcc ttt gga gag ctg agg agt ttg gct gac caa ggg att     1533
 Leu Val Ala Ala Phe Gly Glu Leu Arg Ser Leu Ala Asp Gln Gly Ile
              20                  25                  30

 att aac tat cct tat tct acc aga gaa gtt gtc aac ata gtc aaa cat     1581
 Ile Asn Tyr Pro Tyr Ser Thr Arg Glu Val Val Asn Ile Val Lys His
          35                  40                  45

 tta cag aaa ttt ccg act gaa ggt ctc tcc agt gta gtt cga aat gtg     1629
 Leu Gln Lys Phe Pro Thr Glu Gly Leu Ser Ser Val Val Arg Asn Val
      50                  55                  60

 ttt gac ttt gat tcc tac aac aat gac atg agg gag ata ttg att aac     1677
 Phe Asp Phe Asp Ser Tyr Asn Asn Asp Met Arg Glu Ile Leu Ile Asn
  65                  70                  75                  80

 act tta cac aaa tac ggg ata cct atc gga gca aag cct acc agt gtg     1725
 Thr Leu His Lys Tyr Gly Ile Pro Ile Gly Ala Lys Pro Thr Ser Val
                  85                  90                  95

 cag ctg gca aag gag ttg act ctg cca gaa caa acg ttc atg ggc tac     1773
 Gln Leu Ala Lys Glu Leu Thr Leu Pro Glu Gln Thr Phe Met Gly Tyr
             100                 105                 110

 tgg aca att ggt cag gca aga agt ggg atg caa aaa ctc ttg tgt cca     1821
 Trp Thr Ile Gly Gln Ala Arg Ser Gly Met Gln Lys Leu Leu Cys Pro
         115                 120                 125

 gtg gaa act cat cat ata gac ata aag ggt cca gca ctt ata aat ata     1869
 Val Glu Thr His His Ile Asp Ile Lys Gly Pro Ala Leu Ile Asn Ile
     130                 135                 140

 cag gag tat cca ata gaa aga cat gaa gaa aga tcc cta aac ttt act     1917
 Gln Glu Tyr Pro Ile Glu Arg His Glu Glu Arg Ser Leu Asn Phe Thr
 145                 150                 155                 160

 gaa gaa tgt gcc tca tgg aga ata cca ttg gat gaa att aat ata atc     1965
 Glu Glu Cys Ala Ser Trp Arg Ile Pro Leu Asp Glu Ile Asn Ile Ile
                 165                 170                 175

 tgt gac att gct aca tca cat gaa aat gag caa aat act ctc tat gta     2013
 Cys Asp Ile Ala Thr Ser His Glu Asn Glu Gln Asn Thr Leu Tyr Val
             180                 185                 190

 gtt aca tgc aat ccc gct tcc ctg tac ttt atg aat atg act ggg aaa     2061
 Val Thr Cys Asn Pro Ala Ser Leu Tyr Phe Met Asn Met Thr Gly Lys
         195                 200                 205

 agt ggc ttc ttt gtg gac ttt ttt gat atc ttc cca aga aca gcc aat     2109
 Ser Gly Phe Phe Val Asp Phe Phe Asp Ile Phe Pro Arg Thr Ala Asn
     210                 215                 220

 ggc gtt tgg cac cct ttt gtg aca gtg gca ccg ctg gga agt cct ctc     2157
 Gly Val Trp His Pro Phe Val Thr Val Ala Pro Leu Gly Ser Pro Leu
 225                 230                 235                 240

 aaa ggt caa gtg gtt ctc cat gag cag cag agt aat gtt atc ctg ttg     2205
 Lys Gly Gln Val Val Leu His Glu Gln Gln Ser Asn Val Ile Leu Leu
                 245                 250                 255

 tta gat act act ggc cgg gcc ctt cat cgt ctc atc ctc cct tcc gag     2253
 Leu Asp Thr Thr Gly Arg Ala Leu His Arg Leu Ile Leu Pro Ser Glu
             260                 265                 270

 aag ttt aca tct aag aaa cct ttc tgg tgg aac aaa gaa gaa gct gaa     2301
 Lys Phe Thr Ser Lys Lys Pro Phe Trp Trp Asn Lys Glu Glu Ala Glu
         275                 280                 285

 act tat aaa atg tgt aaa gaa ttt tca cac aaa aac tgg ctg gtg ttc     2349
 Thr Tyr Lys Met Cys Lys Glu Phe Ser His Lys Asn Trp Leu Val Phe
     290                 295                 300

 tac aaa gaa aaa ggg aac agc ctg act gtg ctg gat gtt cta gaa ggg     2397
 Tyr Lys Glu Lys Gly Asn Ser Leu Thr Val Leu Asp Val Leu Glu Gly
 305                 310                 315                 320

 cga act cac acc atc tca ctt ccc atc aac ctc aag aca gtt ttc ctt     2445
 Arg Thr His Thr Ile Ser Leu Pro Ile Asn Leu Lys Thr Val Phe Leu
                 325                 330                 335

 gta gca gag gac aaa tgg ctt ctg gtg gag agc aaa aca aat cag aaa     2493
 Val Ala Glu Asp Lys Trp Leu Leu Val Glu Ser Lys Thr Asn Gln Lys
             340                 345                 350

 tat ctt tta act aag cct gca cac atc gaa tct gag ggt agt ggg gtt     2541
 Tyr Leu Leu Thr Lys Pro Ala His Ile Glu Ser Glu Gly Ser Gly Val
         355                 360                 365

 tgc cag ttg tat gtg ctg aaa gag gag ccg ccc agc aca ggg ttt gga     2589
 Cys Gln Leu Tyr Val Leu Lys Glu Glu Pro Pro Ser Thr Gly Phe Gly
     370                 375                 380

 gtt aca caa gaa aca gag ttc agc ata cct cat aaa att tcc agt gat     2637
 Val Thr Gln Glu Thr Glu Phe Ser Ile Pro His Lys Ile Ser Ser Asp
 385                 390                 395                 400

 caa cta tca tct gaa cat cta agt tca gct gtg gaa caa aag att gcc     2685
 Gln Leu Ser Ser Glu His Leu Ser Ser Ala Val Glu Gln Lys Ile Ala
                 405                 410                 415

 tct ccc aac aga att ctc tca gat gag aaa aat tat gct aca ata gtt     2733
 Ser Pro Asn Arg Ile Leu Ser Asp Glu Lys Asn Tyr Ala Thr Ile Val
             420                 425                 430

 gtt ggt ttt cca gat ctc atg tca ccc agt gaa gtt tat tct tgg aag     2781
 Val Gly Phe Pro Asp Leu Met Ser Pro Ser Glu Val Tyr Ser Trp Lys
         435                 440                 445

 aga cca tca tct ttg cat aaa cga agt ggc act gat aca tca ttc tat     2829
 Arg Pro Ser Ser Leu His Lys Arg Ser Gly Thr Asp Thr Ser Phe Tyr
     450                 455                 460

 aga gga aag aag aaa agg ggg act cca aaa caa agc aat tgt gtg act     2877
 Arg Gly Lys Lys Lys Arg Gly Thr Pro Lys Gln Ser Asn Cys Val Thr
 465                 470                 475                 480

 ctt tta gat acg aat cag gta gtg agg att tta ccc cca gga gaa gtc     2925
 Leu Leu Asp Thr Asn Gln Val Val Arg Ile Leu Pro Pro Gly Glu Val
                 485                 490                 495

 cct cta aaa gat atc tac cca aaa gat gtt act cct cca caa aca tct     2973
 Pro Leu Lys Asp Ile Tyr Pro Lys Asp Val Thr Pro Pro Gln Thr Ser
             500                 505                 510

 ggt tat ata gaa gtc act gat ctt caa tca aag aaa ctc cga tat atc     3021
 Gly Tyr Ile Glu Val Thr Asp Leu Gln Ser Lys Lys Leu Arg Tyr Ile
         515                 520                 525

 cct att ccc aga tca gaa tct ctc tcg ccg tat acc aca tgg ctg tcg     3069
 Pro Ile Pro Arg Ser Glu Ser Leu Ser Pro Tyr Thr Thr Trp Leu Ser
     530                 535                 540

 acc att tca gac aca gat gca ctg ctg gct gag tgg gac aaa agc ggt     3117
 Thr Ile Ser Asp Thr Asp Ala Leu Leu Ala Glu Trp Asp Lys Ser Gly
 545                 550                 555                 560

 gtt gtt act gtt gat atg gga ggt cac atc agg ctt tgg gaa act gga     3165
 Val Val Thr Val Asp Met Gly Gly His Ile Arg Leu Trp Glu Thr Gly
                 565                 570                 575

 ctt gaa cgt ctg cag cga tca ctc atg gaa tgg aga aac atg att gga     3213
 Leu Glu Arg Leu Gln Arg Ser Leu Met Glu Trp Arg Asn Met Ile Gly
             580                 585                 590

 caa gat gac aga aat atg cag ata aca atc aac aga gac agt ggt gaa     3261
 Gln Asp Asp Arg Asn Met Gln Ile Thr Ile Asn Arg Asp Ser Gly Glu
         595                 600                 605

 gat gta agc tcc ccc aaa cac ggg aag gag gac cca gac aac atg cct     3309
 Asp Val Ser Ser Pro Lys His Gly Lys Glu Asp Pro Asp Asn Met Pro
     610                 615                 620

 cac gtg ggc ggc aac act tgg gct ggc gga aca ggg gga aga gac acg     3357
 His Val Gly Gly Asn Thr Trp Ala Gly Gly Thr Gly Gly Arg Asp Thr
 625                 630                 635                 640

 gca ggc ctg ggt ggc aaa gga ggc cct tac cgg ctg gat gca ggc cat     3405
 Ala Gly Leu Gly Gly Lys Gly Gly Pro Tyr Arg Leu Asp Ala Gly His
                 645                 650                 655

 acg gtg tac cag gtc tct cag gct gag aaa gat gca gtt ccc gaa gag     3453
 Thr Val Tyr Gln Val Ser Gln Ala Glu Lys Asp Ala Val Pro Glu Glu
             660                 665                 670

 gtc aag aga gct gct aga gag atg ggc cag aga gca ttc cag cag agg     3501
 Val Lys Arg Ala Ala Arg Glu Met Gly Gln Arg Ala Phe Gln Gln Arg
         675                 680                 685

 cta aag gag atc caa atg agt gaa tac gat gct gca acc tat gaa agg     3549
 Leu Lys Glu Ile Gln Met Ser Glu Tyr Asp Ala Ala Thr Tyr Glu Arg
     690                 695                 700

 ttt tca ggt gct gtt cgg cga cag gtg cac tcc ctc cga atc atc ctg     3597
 Phe Ser Gly Ala Val Arg Arg Gln Val His Ser Leu Arg Ile Ile Leu
 705                 710                 715                 720

 gat aat tta cag gct aaa ggt aaa gaa aga caa tgg cta aga cat caa     3645
 Asp Asn Leu Gln Ala Lys Gly Lys Glu Arg Gln Trp Leu Arg His Gln
                 725                 730                 735

 gct act gga gaa tta gat gat gcc aag atc att gat ggg ctg act gga     3693
 Ala Thr Gly Glu Leu Asp Asp Ala Lys Ile Ile Asp Gly Leu Thr Gly
             740                 745                 750

 gaa aaa gcc atc tac aaa cgt cgg ggt gag ctg gag cca caa ctt ggc     3741
 Glu Lys Ala Ile Tyr Lys Arg Arg Gly Glu Leu Glu Pro Gln Leu Gly
         755                 760                 765

 agc cca caa cag aaa ccc aag cgt ctg cgc ctg gtg gta gat gtg tct     3789
 Ser Pro Gln Gln Lys Pro Lys Arg Leu Arg Leu Val Val Asp Val Ser
     770                 775                 780

 ggt agc atg tac cgt ttc aac agg atg gat ggc cgg ctt gag cgc aca     3837
 Gly Ser Met Tyr Arg Phe Asn Arg Met Asp Gly Arg Leu Glu Arg Thr
 785                 790                 795                 800

 atg gag gct gtg tgt atg gtc atg gaa gcc ttc gag aac tat gag gag     3885
 Met Glu Ala Val Cys Met Val Met Glu Ala Phe Glu Asn Tyr Glu Glu
                 805                 810                 815

 aag ttc cag tat gac atc gtt gga cac tct gga gat ggc tac aac att     3933
 Lys Phe Gln Tyr Asp Ile Val Gly His Ser Gly Asp Gly Tyr Asn Ile
             820                 825                 830

 ggt ctg gtt cca atg aac aaa atc ccc aag gac aat aag caa aga cta     3981
 Gly Leu Val Pro Met Asn Lys Ile Pro Lys Asp Asn Lys Gln Arg Leu
         835                 840                 845

 gaa att ctg aag aca atg cat gcc cac tct cag ttc tgc atg agt ggg     4029
 Glu Ile Leu Lys Thr Met His Ala His Ser Gln Phe Cys Met Ser Gly
     850                 855                 860

 gac cac acg tta gaa ggg aca gaa cat gcc atc aag gaa att gtc aaa     4077
 Asp His Thr Leu Glu Gly Thr Glu His Ala Ile Lys Glu Ile Val Lys
 865                 870                 875                 880

 gaa gaa gct gat gag tac ttt gtc ata gtc ttg agt gat gca aat ctg     4125
 Glu Glu Ala Asp Glu Tyr Phe Val Ile Val Leu Ser Asp Ala Asn Leu
                 885                 890                 895

 tca cga tat gga ata cat cct gct aag ttt gct caa atc ctc aca aga     4173
 Ser Arg Tyr Gly Ile His Pro Ala Lys Phe Ala Gln Ile Leu Thr Arg
             900                 905                 910

 gac cct caa gta aat gct ttt gcc att ttt att ggc tct tta ggt gat     4221
 Asp Pro Gln Val Asn Ala Phe Ala Ile Phe Ile Gly Ser Leu Gly Asp
         915                 920                 925

 caa gca acc agg ctt cag aga act tta cca gct ggt cgg tct ttc gtt     4269
 Gln Ala Thr Arg Leu Gln Arg Thr Leu Pro Ala Gly Arg Ser Phe Val
     930                 935                 940

 gcc atg gat acc aag gat atc cct cag att tta caa cag atc ttc acc     4317
 Ala Met Asp Thr Lys Asp Ile Pro Gln Ile Leu Gln Gln Ile Phe Thr
 945                 950                 955                 960

 tcc acc atg ttg tcg agt gtc taa gaagtgccct tcatcaccct gatgacacca    4371
 Ser Thr Met Leu Ser Ser Val 
                 965

 ggatttgaaa taagacagga ataaagagta ttctgaaaaa aagaagatat ggatgaagtg   4431

 aacccatgca gtgactggat gattccggca ttcctgggtc ttcctacact tgctccgtaa   4491

 tgagaattca gagaagcagc cagaaggaga cttaaacatg gaaagatact ccactgatga   4551

 gtttagaagt gattagggca agctagttga cctgcacttt atcaaaggtt ggggttaaag   4611

 gaaggtggtt ttgagaacta tgtgtttggt ctatttccaa aaacctgagg gggagaaaat   4671

 actttgcttt tgccttaaca catcatctgg tcacgttaga aaagtgaccc catcaaactg   4731

 agcctttgat gtcacattct gacacaagat gcaagtctgt gcaaaaccca ccaaaatgct   4791

 cctatccaac aattattttt attttctccc tgctctgtat tgaccagaaa acaatgattt   4851

 tataatattt aacccaccaa aaagtccctc caacagcaat atcttatgaa aggctggctg   4911

 ttctcaataa tttcattttc ttggccaaag ccaaaaggaa tcaaaaaatc cttggagtgc   4971

 ttgcctttcc acgtgacttt taaaaggctc ttaaagagca aatgtcctct tctccttgct   5031

 gctagagtgg gaggagaaag atgtcttgcc ttaaaagttt actgtttctt ctgttcttct   5091

 agcatctctc aaaaaattca cagtactcca ttttggggtc caaactgtaa tgctcaaaat   5151

 aataaatgct tacacgaaaa ttatttattg agaatattca tataaaaatt acctaaagca   5211

 aagtaaaaaa agtaaaatca aggtggtata tttgaagtga atggtgattg gaaattttta   5271

 gctgtaacaa aaagaaagaa aacaactttt tttaaagcct cattctcttt tctttcaaaa   5331

 tgtaccttat tcccacacac tcttgggctg acctttattt tatcaataag ctcaatatta   5391

 ctttgtttaa aataagatgc ttcagcaaaa gtcattctct ctttaaccat ataatttaaa   5451

 aactcctctt cacgattgat agcaaaatca gaaacgttag ggcaccagtg agttgaaaaa   5511

 actggtctta agttggaaaa actattatta ataatattat cctatccatc catatctatt   5571

 gaaattgtac aggtccataa tttcatttta attaattata ggaaagaaga aaagataata   5631

 cccatttgtt ctatcacccc tctccctatc attaactatc aaataaataa ataaaagcaa   5691

 tctgatttcc aacgtggtaa aaaaaaaa                                      5719




      <210> 21
      <211> 1046
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (440)..(991)

      <400> 21
 aataaataaa acaaatgaaa aatagcagca ttgcatttct ttgcacagag aaaggtgaga     60

 ggaggagagt ggcattatcc ctcctaggca gagtgcctgt gcgtgagggc gcccataaag    120

 ccctgtgctg cctctttaaa cgaaggattt tcgatcatga caacgatagc aattgatata    180

 ccttcaaaat acgtgtccag tgagtgttga ttgtgtgtgg tttctctagg agaccgtgtt    240

 catgcaacac agcattattt caccgccttt accccagctt cttcatacac atgcacttgt    300

 caagggctct ttggctgaag agaagttaga agtttccaga tatggagggg tattttcagc    360

 agatatgccc accgccatgg ttttgtcagc tctgtagggt ggtcttgcac cctgctcact    420

 gctggcatca cctgagcct atg gca gat acc cag tgc tgc ccg cca cca tgt     472
                      Met Ala Asp Thr Gln Cys Cys Pro Pro Pro Cys
                        1               5                  10

 gag ttc atc agc tct gca ggc aca gac ctt gca cta gga atg ggc tgg      520
 Glu Phe Ile Ser Ser Ala Gly Thr Asp Leu Ala Leu Gly Met Gly Trp
              15                  20                  25

 gac gcc acc ctc tgc ctc tta cca ttc act ggg ttt ggc aag tgt gct      568
 Asp Ala Thr Leu Cys Leu Leu Pro Phe Thr Gly Phe Gly Lys Cys Ala
          30                  35                  40

 ggg atc tgg aat cac atg gat gag gaa ccc gat aat ggt gac gac cga      616
 Gly Ile Trp Asn His Met Asp Glu Glu Pro Asp Asn Gly Asp Asp Arg
      45                  50                  55

 ggt agc agg cga acc act ggc cag ggc agg aag tgg gca gct cac ggg      664
 Gly Ser Arg Arg Thr Thr Gly Gln Gly Arg Lys Trp Ala Ala His Gly
  60                  65                  70                  75

 act atg gct gca ccg cgg gtt cat acc gac tac cat cct gga ggt ggg      712
 Thr Met Ala Ala Pro Arg Val His Thr Asp Tyr His Pro Gly Gly Gly
                  80                  85                  90

 agc gca tgc tca tct gta aaa gtc cgg tcc cac gtt gga cac acc ggg      760
 Ser Ala Cys Ser Ser Val Lys Val Arg Ser His Val Gly His Thr Gly
              95                 100                 105

 gtc ttc ttc ttt gtt gac cag gat cct ctg gca gtg tct tta aca agc      808
 Val Phe Phe Phe Val Asp Gln Asp Pro Leu Ala Val Ser Leu Thr Ser
         110                 115                 120

 cag agt ctg atc cca ccg ctc ata aag cca ggg ttg ttg aaa gct tgg      856
 Gln Ser Leu Ile Pro Pro Leu Ile Lys Pro Gly Leu Leu Lys Ala Trp
     125                 130                 135

 ggc ttc ctc ctc ctc tgt gcg cag ccc tca gca aac ggt cac agc ctg      904
 Gly Phe Leu Leu Leu Cys Ala Gln Pro Ser Ala Asn Gly His Ser Leu
 140                 145                 150                 155

 tgc tgt ctg ctg tac acc gac ttg gta tca tcc cat gaa ctg tcc ccc      952
 Cys Cys Leu Leu Tyr Thr Asp Leu Val Ser Ser His Glu Leu Ser Pro
                 160                 165                 170

 ttt ctc act ccc acg tgc tct gtg ctt agg gcc ctc tga tgccccatct      1001
 Phe Leu Thr Pro Thr Cys Ser Val Leu Arg Ala Leu 
             175                 180

 gcctgtgctt cctgcaactg tttagcaagc acctattatc tatag                   1046




      <210> 22
      <211> 3385
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2663)..(2878)

      <400> 22
 acacgcagct agccggagcc cggaccaggc gcctgtgcct cctcctcgtc cctcgccgcg     60

 tccgcgaagc ctggagccgg cgggagcccc gcgctcgcca tgtcgggcga gctcagcaac    120

 aggttccaag gagggaaggc gttcggcttg ctcaaagccc ggcaggagag gaggctggcc    180

 gagatcaacc gggagcttct gtgtgaccag aagtacagtg atgaagagaa ccttccagaa    240

 aagctcacag ccttcaaaga gaagtacatg gagtttgacc tgaacaatga aggcgagatt    300

 gacctgatgt ctttaaagag gatgatggag aagcttggtg tccccaagac ccacctggag    360

 atgaagaaga tgatctcaga ggtgacagga ggggtcagtg acactatatc ctaccgagac    420

 tttgtgaaca tgatgctggg gaaacggtcg gctgtcctca agttagtcat gatgtttgaa    480

 ggaaaagcca acgagagcag ccccaagcca gttggccccc ctccagagag agacattgct    540

 agcctgccct gaggaccccg cctggactcc ccagccttcc caccccatac ctccctcccg    600

 atcttgctgc ccttcttgac acactgtgat ctctctctct ctcatttgtt tggtcattga    660

 gggtttgttt gtgttttcat caatgtcttt gtaaagcaca aattatctgc cttaaagggg    720

 ctctgggtcg gggaatcctg agccttgggt cccctccctc tcttcttccc tccttccccg    780

 ctccctgtgc agaagggctg atatcaaacc aaaaactaga gggggcaggg ccagggcagg    840

 gaggcttcca gcctgtgttc ccctcacttg gaggaaccag cactctccat cctttcagaa    900

 agtctccaag ccaagttcag gctcactgac ctggctctga cgaggacccc aggccactct    960

 gagaagacct tggagtaggg acaaggctgc agggcctctt tcgggtttcc ttggacagtg   1020

 ccatggttcc agtgctctgg tgtcacccag gacacagcca ctcggggccc cgctgcccca   1080

 gctgatcccc actcattcca cacctcttct catcctcagt gatgtgaagg tgggaaggaa   1140

 aggagcttgg cattgggagc ccttcaagaa ggtaccagaa ggaaccctcc agtcctgctc   1200

 tctggccaca cctgtgcagg cagctgagag gcagcgtgca gccctactgt cccttactgg   1260

 ggcagcagag ggcttcggag gcagaagtga ggcctggggt ttggggggaa aggtcagctc   1320

 agtgctgttc caccttttag ggaggatact gaggggacca ggatgggaga atgaggagta   1380

 aaatgctcac ggcaaagtca gcagcactgg taagccaaga ctgagaaata caaggttgct   1440

 tgtctgaccc caatctgctt gaaacctgac tctgcttctc tcatttgtct tcctacccta   1500

 ctcacataat tcactcattg actcactcat tcaccagata tttattgacc tgctattata   1560

 agctatacat cctcccatgt tgtcctggca tgtgcagtat acacggtcta actcatctct   1620

 ccccagatct ctcagaacct tgagcttggg aattgaactg gggtcacctg tgtcctttct   1680

 tatggactcg caggatttta gaaccctaat gcaccctgga gggtagctgg gccagacttc   1740

 tcatttcaca ggtgatgaga ctggtgcccc acagggatta agtgccttgc ccaaggtcag   1800

 gcttatctcc agagggaggt gccctggact ggggcccaga tgttcaggga ccctgcctac   1860

 acctcatttc cagtgtgggc tgccttagtt agttatgaga acagggaagg gctgggaaga   1920

 gacagcctcc aaggtcaaca cttggagagg gtttcacttg ctctgaagac cctggtccag   1980

 gattcgccct ctcccatgcc ttcaagtcag catcaggctt agggcaaaga ccaggcctct   2040

 gaagctgcct cttgtaattc atgcaggaag atgtcaaagt cagccccatc ttggctgatc   2100

 agggtgttca gccttaaccc cacctgtgtt ctgaagtctc ttaccctacc tgctcaggac   2160

 tgagacagtt attcactgaa catatttatt aagcacttgc tgtaggccaa cagttaagaa   2220

 tccaataatg aaatggacag attcatggaa cttagagtcc aataggaaag tgagacccag   2280

 acaatgacaa tgagataaat gttaggaagg gggaggtatg gggtgacttc cctgcagtcc   2340

 tgggggccta gatgggccca agactgggtg agagtcttgg cagagccttt gcaacacctt   2400

 aagtggacag gactgggagg tcttggtggt tggagccaac gtgggttccc tgcggctcct   2460

 tagtcacctc tgatagcaga ttgagggagg aaaacaggta aggcatgagg aaatggccag   2520

 gttgggttaa cccactggtt tcaaccagtt caggaatgag gttatttggc catgactggc   2580

 tgatcttgag ctcaaggatc tgcttcaaat gcacacaggc ctagttgaag tttaaacccc   2640

 agcaaaacat tcctccctgt aa atg gaa aat cct act tct acc ccc acc ctg    2692
                          Met Glu Asn Pro Thr Ser Thr Pro Thr Leu
                            1               5                  10

 ccc tgt ttt ttt ttt ttt ttt tcc cca aga tca tta gat gtc ctc acc     2740
 Pro Cys Phe Phe Phe Phe Phe Ser Pro Arg Ser Leu Asp Val Leu Thr
                  15                  20                  25

 cct cct cac tgc ctc tcc tct ctg gga cag gct ggg acc ttt gag gaa     2788
 Pro Pro His Cys Leu Ser Ser Leu Gly Gln Ala Gly Thr Phe Glu Glu
              30                  35                  40

 gat aaa gcc ttc ctt gac tac cca tca tat tca gtg tcc ctg ttc ctc     2836
 Asp Lys Ala Phe Leu Asp Tyr Pro Ser Tyr Ser Val Ser Leu Phe Leu
          45                  50                  55

 act cag aga gga agg cag aac cag tca ggc tta ttt cag taa gttccac     2885
 Thr Gln Arg Gly Arg Gln Asn Gln Ser Gly Leu Phe Gln 
      60                  65                  70

 agttctacaa gactgcagga attctcctta agggaggaga gcaagcaggt gtggccccag   2945

 cttctggaaa tggcagaaga gagggttttc tcattgaatg ggggtggggg ctcgtgtgtc   3005

 ctgggaaacc ccatcagtcc cttcatttct tgagactcaa ctcctgggag gagagggtct   3065

 caagagttgt ccctggaagg agggcggggg cagtctgcat ctatttcagg ttgtggctct   3125

 tggttctagg actcttactt ctctggctaa gggctcagct tcttgggact tcaaccatct   3185

 tctttctgaa agaccaaatc taatgtaacc agtaacgtga ggactgccaa gtatggcttt   3245

 gtccctatga ctcagaggag ggtttgtcgg gcaaattcag gtggatgaag tatgtgtgtg   3305

 cgtgtgcatg ggagtgtgcg tggactggga tatcatctct acagcctgca aataaaccag   3365

 acaaacttaa aaaaaaaaaa                                               3385




      <210> 23
      <211> 1876
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (314)..(1255)

      <400> 23
 agctgaccca cagagtaggg aatcatggct ggagaattgg atagcagagt aatgtttgac     60

 ctctggaaac actcattctc aatgcaagat cctccgctgc aatgctgagt acgtatcgtc    120

 cactctgagc cttagaggtg ggggttcatc aggagcactt cgaggaggag gaggaggagg    180

 ccggggtgga ggggtgggct ctggcggcct ctgtcgagcc ctccgctcct atgcgctctg    240

 cactcggcgc accgcccgca cctgccgcgg ggacctcgcc ttccattcgg cggtacatgg    300

 catcgaagac ctg   atg atc cag cac aac tgc tcc cgc cag ggc cct aca     349
                  Met Ile Gln His Asn Cys Ser Arg Gln Gly Pro Thr
                    1               5                  10

 gcc cct ccc ccg ccc cgg ggc ccc gcc ctt cca ggc gcg ggc tcc ggc      397
 Ala Pro Pro Pro Pro Arg Gly Pro Ala Leu Pro Gly Ala Gly Ser Gly
          15                  20                  25

 ctc cct gcc ccg gac cct tgt gac tat gaa ggc cgg ttt tcc cgg ctg      445
 Leu Pro Ala Pro Asp Pro Cys Asp Tyr Glu Gly Arg Phe Ser Arg Leu
      30                  35                  40

 cat ggt cgt ccc ccg ggg ttc ttg cat tgc gct tcc ttc ggg gac ccc      493
 His Gly Arg Pro Pro Gly Phe Leu His Cys Ala Ser Phe Gly Asp Pro
  45                  50                  55                  60

 cat gtg cgc agc ttc cac cat cac ttt cac aca tgc cgt gtc caa gga      541
 His Val Arg Ser Phe His His His Phe His Thr Cys Arg Val Gln Gly
                  65                  70                  75

 gct tgg cct cta ctg gat aat gac ttc ctc ttt gtc caa gcc acc agc      589
 Ala Trp Pro Leu Leu Asp Asn Asp Phe Leu Phe Val Gln Ala Thr Ser
              80                  85                  90

 tcc ccc atg gcg ttg ggg gcc aac gct acc gcc acc cgg aag ctc acc      637
 Ser Pro Met Ala Leu Gly Ala Asn Ala Thr Ala Thr Arg Lys Leu Thr
          95                 100                 105

 atc ata ttt aag aac atg cag gaa tgc att gat cag aag gtg tat cag      685
 Ile Ile Phe Lys Asn Met Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln
     110                 115                 120

 gct gag gtg gat aat ctt cct gta gcc ttt gaa gat ggt tct atc aat      733
 Ala Glu Val Asp Asn Leu Pro Val Ala Phe Glu Asp Gly Ser Ile Asn
 125                 130                 135                 140

 gga ggt gac cga cct ggg gga tcc agt ttg tcg att caa act gct aac      781
 Gly Gly Asp Arg Pro Gly Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn
                 145                 150                 155

 cct ggg aac cat gtg gag atc caa gct gcc tac att ggc aca act ata      829
 Pro Gly Asn His Val Glu Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile
             160                 165                 170

 atc att cgg cag aca gct ggg cag ctc tcc ttc tcc atc aag gta gca      877
 Ile Ile Arg Gln Thr Ala Gly Gln Leu Ser Phe Ser Ile Lys Val Ala
         175                 180                 185

 gag gat gtg gcc atg gcc ttc tca gct gaa cag gac ctg cag ctc tgt      925
 Glu Asp Val Ala Met Ala Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys
     190                 195                 200

 gtt ggg ggg tgc cct cca agt cag cga ctc tct cga tca gag cgc aat      973
 Val Gly Gly Cys Pro Pro Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn
 205                 210                 215                 220

 cgt cgg gga gct ata acc att gat act gcc aga cgg ctg tgc aag gaa     1021
 Arg Arg Gly Ala Ile Thr Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu
                 225                 230                 235

 ggg ctt cca gtg gaa gat gct tac ttc cat tcc tgt gtc ttt gat gtt     1069
 Gly Leu Pro Val Glu Asp Ala Tyr Phe His Ser Cys Val Phe Asp Val
             240                 245                 250

 tta att tct ggt gat ccc aac ttt acc gtg gca gct cag gca gca ctg     1117
 Leu Ile Ser Gly Asp Pro Asn Phe Thr Val Ala Ala Gln Ala Ala Leu
         255                 260                 265

 gag gat gcc cga gcc ttc ctg cca gac tta gag aag ctg cat ctc ttc     1165
 Glu Asp Ala Arg Ala Phe Leu Pro Asp Leu Glu Lys Leu His Leu Phe
     270                 275                 280

 ccc tca gat gct ggg gtt cct ctt tcc tca gca acc ctc tta gct cca     1213
 Pro Ser Asp Ala Gly Val Pro Leu Ser Ser Ala Thr Leu Leu Ala Pro
 285                 290                 295                 300

 ctc ctt tct ggg ctc ttt gtt ctg tgg ctt tgc att cag taa ggggacc     1262
 Leu Leu Ser Gly Leu Phe Val Leu Trp Leu Cys Ile Gln 
                 305                 310

 atcagtccca ttactagttt ggaaatgatt tggagataca gattggcata gaagaatgta   1322

 aagaatcatt aaaggaagca gggcctagga gacacgtgaa acaatgacat tatccagagt   1382

 cagatgaggc tgcagtccag ggttgaaatt atcacagaat aaggattctg ggcaaggtta   1442

 ctgcattccg gatctctgtg gggctcttca ccaatttttc cagcctcatt tatagtaaac   1502

 aaattgttct aatccattta ctgcagattt cacccttata agtttagagg tcatgaaggt   1562

 tttaatgatc agtaaagatt taagggttga gatttttaag aggcaagagc tgaaagcaga   1622

 agacatgatc attagccata agaaactcaa aggaggaaga cataattagg gaaagaagtc   1682

 tatttgatga atatgtgtgt gtaaggtatg ttctgctttc ttgattcaaa aatgaagcag   1742

 gcattgtcta gctcttaggt gaagggagtc tctgcttttg aagaatggca caggtaggac   1802

 agaagtatca tccctacccc ctaactaatc tgttattaaa gctacaaatt cttcacacca   1862

 tcaaaaaaaa aaaa                                                     1876




      <210> 24
      <211> 3130
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1357)..(1785)

      <400> 24
 atggagccca tatatgagga gtacctagca aatcatggaa caatagtaaa accatattac     60

 tggctaagct tctctctcga ttgctctaat tgtccttacc atattcgaac aggtgaagaa    120

 gcaagagttt ccctcacaga attttgtcag atttttggat tcccttatgg gacaacattt    180

 cctcaaacaa aacacctcac attttatgaa ctaaaaactt cttctggtag cctggtgcaa    240

 aagggccatg ctagcagttg cactgggaat tatatccatc cagaatcaat gctctttgaa    300

 atgaatggtt atcttgactc agccatatac aataatgaca gcatcaggca tatcattctg    360

 tattccaaca actccccttg taatgaagct aaccactgct gcatcagcaa aatgtataat    420

 ttcctgatta cgtatccagg catcactctt agtatttatt tttctcagct ctatcatact    480

 gagatggact ttcctgcctc agcatggaac cgcgaagctc tccggagcct ggccagctta    540

 tggccgcggg ttgttttgag tccaataagt ggtgggatct ggcattctgt tctccacagc    600

 tttataagtg gtgtctcagg atcacatgtt tttcagccca ttttaactgg gagagcactg    660

 gctgacaggc acaacgcata tgaaatcaat gccataacag gcgtaaaacc ttacttcact    720

 gatgttcttc tccagacaaa aaggaatcca aacacaaaag ctcaggaggc tttagagagc    780

 taccccttaa acaatgcctt tcctggacag tcttttcaaa tgccgagtgg acaactccaa    840

 cccaacctac ctccagacct cagggctcct gttgtttttg tgctagtgcc tctcagggac    900

 ttaccaccaa tgcatatggg ccaaaaccca aataaaccca ggaatatcgt aaggcactta    960

 aatatgcctc aaatgtcatt ccaggaaacc gaggaccttg gaaggcttcc cactggaagg   1020

 tcagtggaga tagtggaaat cacagaacag tttgcaaccc cgccccttgc ctgcggagag   1080

 cccgcgcctg cgcgctgtgt cctgcgcgct ccttccctcg cgcgcgctct ccgtggaaga   1140

 gcaggggcag cgtgggaggc gccaagggag cgcgaacctg aggaggaaga aacggggcta   1200

 gcgcgcaggc ccagaacggt ccgagccgcg gcagtcggcg acgccccaga gcggaagagg   1260

 gaagtgaatc aggcgccggg tagtgggttg ctgggctggg cttgctgagg tagaggcagc   1320

 gccaagaaga ggcctttgcc gctggtcggg attggg  atg tcg aag aac aca gtg    1374
                                          Met Ser Lys Asn Thr Val
                                            1               5

 tcg tcg gcc cgc ttc cgg aag gtg gac gtg gat gaa tat gac gag aac     1422
 Ser Ser Ala Arg Phe Arg Lys Val Asp Val Asp Glu Tyr Asp Glu Asn
              10                  15                  20

 aag ttc gtg gac gaa gaa gat ggg ggc gac ggc cag gcc ggg ccc gac     1470
 Lys Phe Val Asp Glu Glu Asp Gly Gly Asp Gly Gln Ala Gly Pro Asp
          25                  30                  35

 gag ggc gag gtg gac tcc tgc ctg cgg caa gga aac atg aca gct gcc     1518
 Glu Gly Glu Val Asp Ser Cys Leu Arg Gln Gly Asn Met Thr Ala Ala
      40                  45                  50

 cta cag gca gct ctg aag aac ccc cct atc aac acc aag agt cag gca     1566
 Leu Gln Ala Ala Leu Lys Asn Pro Pro Ile Asn Thr Lys Ser Gln Ala
  55                  60                  65                  70

 gtg aag gtg ctc atc tct ttt aaa gct aat gat ata gaa aag gca gtt     1614
 Val Lys Val Leu Ile Ser Phe Lys Ala Asn Asp Ile Glu Lys Ala Val
                  75                  80                  85

 caa tct ctg gac aag aat ggt gtg gat ctc cta atg aag tat att tat     1662
 Gln Ser Leu Asp Lys Asn Gly Val Asp Leu Leu Met Lys Tyr Ile Tyr
              90                  95                 100

 aaa gga ttt gag agc ccg tct gac aat agc agt gct atg tta ctg caa     1710
 Lys Gly Phe Glu Ser Pro Ser Asp Asn Ser Ser Ala Met Leu Leu Gln
         105                 110                 115

 tgg cat gaa aag gca ctt gct gct gga gga gta ggg tcc att gtt cgt     1758
 Trp His Glu Lys Ala Leu Ala Ala Gly Gly Val Gly Ser Ile Val Arg
     120                 125                 130

 gtc ttg act gca aga aaa act gtg tag tctgg caggaagtgg attatctgcc     1810
 Val Leu Thr Ala Arg Lys Thr Val 
 135                 140

 tcgggagtgg gaattgctgg tacaaagacc aaaacaacca aatgccaccg ctgccctgtg   1870

 ggtagcatct gtttctctca gctttgcctt cttgcttttt catatctgta aagaaaaaaa   1930

 ttacatatca gttgtccttt aatgaaaatt gggataatat agaagaaatt gtgttaaaat   1990

 agaagtgttt catcctttca aaaccatttc agtgatgttt ataccaatct gtatatagta   2050

 taatttacat tcaagtttaa ttgtgcaact tttaacccct gttggctggt tttttgttct   2110

 gttttgtttt gtattatttt taactaatac tgagagattt ggtcagaatt tgaggccagt   2170

 ttcctagctc attgctagtc aggaaatgat atttataaaa aatatgagag actggcagct   2230

 attaacattg caaaactgga ccatatttcc cttatttaat aagcaaaata tgtttttgga   2290

 ataagtggtg ggtgaatacc actgctaagt tatagctttg tttttgcttg cctcctgatt   2350

 atctgtactg tgggtttaag tatgctactt tctctcagca tccaataatc atggcccctc   2410

 aatttatttg tggtcaccca gggttcagag caagaagtct tgctttatac aaatgtatcc   2470

 ataaaatatc agagcttgtt gggcatgaac atcaaacttt tgttccacta atatggctct   2530

 gtttggaaaa aactgcaaat cagaaagaat gatttgcaga aagaaagaaa aactatggtg   2590

 taatttaaac tctgggcagc ctctgaatga aatgctactt tctttagaaa tataatagct   2650

 gccttagaca ttatgaggta tacaactagt atttaagata ccatttaata tgccccgtaa   2710

 atgtcttcag tgttcttcag ggtagttggg atctcaaaag atttggttca gatccaaaca   2770

 aatacacatt ctgtgtttta gctcagtgtt ttctaaaaaa agaaactgcc acacagcaaa   2830

 aaattgttta ctttgttgga caaaccaaat cagttctcaa aaaatgaccg gtgcttataa   2890

 aaagttataa atatcgagta gctctaaaac aaaccacctg accaagaggg aagtgagctt   2950

 gtgcttagta tttacattgg atgccagttt tgtaatcact gacttatgtg caaactggtg   3010

 cagaaattct ataaactctt tgctgttttt gatacctgct ttttgtttca ttttgttttg   3070

 ttttgtaaaa atgataaaac ttcagaaaat aaaatgtcag tgttgaataa aaaaaaaaaa   3130




      <210> 25
      <211> 2442
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (151)..(1473)

      <400> 25
 aacgctccag acgctgagag gcaggaggca ctagggatcg tccgcaggat tgggactgat     60

 acagaggccg ccacggagcc cgccggagcc accgttcctg ctgctgccgc cgctgcccga    120

 atcggaaccg tcgggccgca gccgccggca     atg ccg cga agg aag gct gct     171
                                      Met Pro Arg Arg Lys Ala Ala
                                        1               5

 tca aat tct ttt agg aca gtg gtg gat atg agt gaa gac ggg gca ggc      219
 Ser Asn Ser Phe Arg Thr Val Val Asp Met Ser Glu Asp Gly Ala Gly
          10                  15                  20

 agg cca cat ctc tta gaa gag gaa ggt gat tgc cac gtc tcc ttc ctc      267
 Arg Pro His Leu Leu Glu Glu Glu Gly Asp Cys His Val Ser Phe Leu
      25                  30                  35

 cat gct gat ggc aag gcg tgc ggg ctg tgt tct ctt gca gcc agc gtc      315
 His Ala Asp Gly Lys Ala Cys Gly Leu Cys Ser Leu Ala Ala Ser Val
  40                  45                  50                  55

 cca tgc tcg gtg gcc cca gaa aag tca gtg tgt agg cct cag cca ctt      363
 Pro Cys Ser Val Ala Pro Glu Lys Ser Val Cys Arg Pro Gln Pro Leu
                  60                  65                  70

 cag gtc cgg cgt aca ttc tcc ctg gac acc atc ctc agc tcc tac ctt      411
 Gln Val Arg Arg Thr Phe Ser Leu Asp Thr Ile Leu Ser Ser Tyr Leu
              75                  80                  85

 ctg ggc cag tgg cca cga gat gct gat ggg gcc ttc acc tgc tgc acc      459
 Leu Gly Gln Trp Pro Arg Asp Ala Asp Gly Ala Phe Thr Cys Cys Thr
          90                  95                 100

 aat gac aag gcc acc cag acg ccc ctg tcc tgg caa gag cta gaa ggt      507
 Asn Asp Lys Ala Thr Gln Thr Pro Leu Ser Trp Gln Glu Leu Glu Gly
     105                 110                 115

 gag cgt gcc agt tcc tgt gca cac aag cgc tca gca tcc tgg ggc agc      555
 Glu Arg Ala Ser Ser Cys Ala His Lys Arg Ser Ala Ser Trp Gly Ser
 120                 125                 130                 135

 aca gac cac cga aaa gag att tcc aag ttg aag caa caa ctg cag agg      603
 Thr Asp His Arg Lys Glu Ile Ser Lys Leu Lys Gln Gln Leu Gln Arg
                 140                 145                 150

 acg aag ctg agc cgc agt ggg aaa gag aag gag cga ggt tca cca ctc      651
 Thr Lys Leu Ser Arg Ser Gly Lys Glu Lys Glu Arg Gly Ser Pro Leu
             155                 160                 165

 cta ggg gac cac gca gtg cgg gga gca ctg agg gcg tcc cct ccc agc      699
 Leu Gly Asp His Ala Val Arg Gly Ala Leu Arg Ala Ser Pro Pro Ser
         170                 175                 180

 ttc ccc tca ggg tcc cct gtc ttg cga ctc agc ccc tgc ctg cac agg      747
 Phe Pro Ser Gly Ser Pro Val Leu Arg Leu Ser Pro Cys Leu His Arg
     185                 190                 195

 agc ctg gaa ggg ctc aac caa gag ctg gag gag gta ttt gtg aag gag      795
 Ser Leu Glu Gly Leu Asn Gln Glu Leu Glu Glu Val Phe Val Lys Glu
 200                 205                 210                 215

 cag gga gaa gag gag ctg ctg agg atc ctt gat atc cct gat ggg cac      843
 Gln Gly Glu Glu Glu Leu Leu Arg Ile Leu Asp Ile Pro Asp Gly His
                 220                 225                 230

 cgg gcc cca gct cct ccc cag agt ggc agc tgt gat cat ccc ctc ctc      891
 Arg Ala Pro Ala Pro Pro Gln Ser Gly Ser Cys Asp His Pro Leu Leu
             235                 240                 245

 ctc ctg gag cct ggc aac ctt gcc agc tct cct tcc atg tcc ttg gca      939
 Leu Leu Glu Pro Gly Asn Leu Ala Ser Ser Pro Ser Met Ser Leu Ala
         250                 255                 260

 tct ccc cag cct tgt ggc ctg gcc agt cat gag gaa cat cgg ggt gcc      987
 Ser Pro Gln Pro Cys Gly Leu Ala Ser His Glu Glu His Arg Gly Ala
     265                 270                 275

 gcc gag gag ctg gca tcc acc ccc aac gac aaa gcc tcc tct cca gga     1035
 Ala Glu Glu Leu Ala Ser Thr Pro Asn Asp Lys Ala Ser Ser Pro Gly
 280                 285                 290                 295

 cac cca gcc ttt ctt gaa gat ggc agc cca tct cca gtc ctt gcc ttt     1083
 His Pro Ala Phe Leu Glu Asp Gly Ser Pro Ser Pro Val Leu Ala Phe
                 300                 305                 310

 gct gcc tcc cct cga cct aat cat agc tac atc ttc aaa cgg gag ccc     1131
 Ala Ala Ser Pro Arg Pro Asn His Ser Tyr Ile Phe Lys Arg Glu Pro
             315                 320                 325

 cca gaa ggc tgt gag aaa gtg cgt gtg ttt gaa gaa gcc acg tct cca     1179
 Pro Glu Gly Cys Glu Lys Val Arg Val Phe Glu Glu Ala Thr Ser Pro
         330                 335                 340

 ggt cct gac ctg gcc ttc ctg act tcc tgt cct gac aag aac aaa gtc     1227
 Gly Pro Asp Leu Ala Phe Leu Thr Ser Cys Pro Asp Lys Asn Lys Val
     345                 350                 355

 cat ttc aac ccg act ggc tca gcc ttc tgc ccc gtc aac ctg atg aag     1275
 His Phe Asn Pro Thr Gly Ser Ala Phe Cys Pro Val Asn Leu Met Lys
 360                 365                 370                 375

 ccc ctc ttc ccc ggc atg ggc ttc atc ttc cgt aac tgc ccc tca aac     1323
 Pro Leu Phe Pro Gly Met Gly Phe Ile Phe Arg Asn Cys Pro Ser Asn
                 380                 385                 390

 ccg gga tct ccc ctt ccc ccg gcc agc ccc agg cca cca cct cgg aag     1371
 Pro Gly Ser Pro Leu Pro Pro Ala Ser Pro Arg Pro Pro Pro Arg Lys
             395                 400                 405

 gat ccg gaa gcc tcc aag gcc tcc cca ctg cca ttc gag cca tgg cag     1419
 Asp Pro Glu Ala Ser Lys Ala Ser Pro Leu Pro Phe Glu Pro Trp Gln
         410                 415                 420

 cgc acc cca cca tca gaa gag cct gtg ctt ttc cag agc tcc ctg atg     1467
 Arg Thr Pro Pro Ser Glu Glu Pro Val Leu Phe Gln Ser Ser Leu Met
     425                 430                 435

 gtc tga gggtcccacc cctgccccac tttaccatag agaccagtgc cttggtggca      1523
 Val 
 440

 ggtccctccc caggtcccct gagatggggt atggaggggc ccttccctct cggccttcga   1583

 gcactttctt tcacttactg tgtcaaagcc ctgggtcctc tttttgatgg gcaccggccc   1643

 ctctgaacgt gatgggacct gccttctcca ctagtagctg ggcagctcac aattcacacc   1703

 tgtgtacctg ccacatccct cacttggtgg aaaacaccca gaaggtcttg agtcccccac   1763

 ccctgggtgt cagtccaaat gactgtatag gaggccctta tttttgtcac agagcaagct   1823

 ggccatgaac gaaggagaga agacgccaca gatttccttc cctctcctcc aggagaccat   1883

 aagatagatc ccccatcctc tcagccctat tcccatgcct ccctctcatt ggaggagctg   1943

 accaaagcag ccctaacggg ccataacact tgaccaattc agctgctggc agagggagga   2003

 aacaagtgtt ttcccaagtg gcattttcat ctcgctttca ccctgactaa agacaatctt   2063

 tagtcagggt gaaagcgaga tgaaagattg tcttaagtag cagcccagcc cgcccagccc   2123

 caggtgggta gtggggagga gagctggcat tcctccaggt ggcaaatggc gactctatac   2183

 tctccgcccg ccccagggct ggatggatta gaaaaatgcc tatttttctt gtatcgatgt   2243

 agagactcta ttttctccca aagacactat ttttgcagct gtttgaagtt tgtatatttt   2303

 ccgtactgca gagcttacac aaaattgaag aatgttaatg ttcgagtttt cttatcttgt   2363

 gtttagaggt tgttttttgc agatcttggt gttaatagac caaataaata aataaatatt   2423

 cccagcaaaa aaaaaaaaa                                                2442




      <210> 26
      <211> 3682
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3552)

      <400> 26
  atg tat gag cgg gaa ctg gag caa ctc cgc cag cag ctc tcc ccc gac      48
  Met Tyr Glu Arg Glu Leu Glu Gln Leu Arg Gln Gln Leu Ser Pro Asp
    1               5                  10                  15

 agg cag cca cag agt agc ggc cct gac cgc ctg gcc tac agc agc cag       96
 Arg Gln Pro Gln Ser Ser Gly Pro Asp Arg Leu Ala Tyr Ser Ser Gln
              20                  25                  30

 aca gcg cag cag aag gtg acc cag tgg gca gaa gag agg gat gaa ctc      144
 Thr Ala Gln Gln Lys Val Thr Gln Trp Ala Glu Glu Arg Asp Glu Leu
          35                  40                  45

 ttc cga caa agc ctg gca aaa ctg cga gag cag ctg gtt aaa gct aat      192
 Phe Arg Gln Ser Leu Ala Lys Leu Arg Glu Gln Leu Val Lys Ala Asn
      50                  55                  60

 acc ttg gtg agg gaa gca aac ttc ctg gct gag gaa atg agc aaa ctc      240
 Thr Leu Val Arg Glu Ala Asn Phe Leu Ala Glu Glu Met Ser Lys Leu
  65                  70                  75                  80

 acc gat tac caa gtg act ctt cag atc cct gct gca aac ctc agt gcc      288
 Thr Asp Tyr Gln Val Thr Leu Gln Ile Pro Ala Ala Asn Leu Ser Ala
                  85                  90                  95

 aat agg aag aga ggt gca ata gtg agt gaa cca gct atc caa gtg agg      336
 Asn Arg Lys Arg Gly Ala Ile Val Ser Glu Pro Ala Ile Gln Val Arg
             100                 105                 110

 agg aaa gga aag agc acc caa gtg tgg acc att gag aag ctg gag aat      384
 Arg Lys Gly Lys Ser Thr Gln Val Trp Thr Ile Glu Lys Leu Glu Asn
         115                 120                 125

 aaa tta att gac atg aga gac ctt tac caa gaa tgg aag gaa aaa gtt      432
 Lys Leu Ile Asp Met Arg Asp Leu Tyr Gln Glu Trp Lys Glu Lys Val
     130                 135                 140

 cct gag gca aag aga ctc tac gga aaa cga ggt gac cct ttc tat gaa      480
 Pro Glu Ala Lys Arg Leu Tyr Gly Lys Arg Gly Asp Pro Phe Tyr Glu
 145                 150                 155                 160

 gcc caa gaa aat cac aac ctc atc ggg gtg gcg aat gta ttc ttg gaa      528
 Ala Gln Glu Asn His Asn Leu Ile Gly Val Ala Asn Val Phe Leu Glu
                 165                 170                 175

 tgc ctc ttc tgt gat gtg aaa ctt cag tat gca gtc cct atc atc agc      576
 Cys Leu Phe Cys Asp Val Lys Leu Gln Tyr Ala Val Pro Ile Ile Ser
             180                 185                 190

 cag cag ggg gag gtt gca ggg cgt ctc cac gtg gaa gtg atg cgt gtt      624
 Gln Gln Gly Glu Val Ala Gly Arg Leu His Val Glu Val Met Arg Val
         195                 200                 205

 aca gga gct gtt cca gag cgt gtg gtg gag gat gac tct tcg gag aat      672
 Thr Gly Ala Val Pro Glu Arg Val Val Glu Asp Asp Ser Ser Glu Asn
     210                 215                 220

 tcc agt gaa agt ggg agc ctt gaa gtc gta gac agc agc ggg gaa atc      720
 Ser Ser Glu Ser Gly Ser Leu Glu Val Val Asp Ser Ser Gly Glu Ile
 225                 230                 235                 240

 att cac cga gtc aaa aag ctg aca tgt cgg gta aaa att aaa gaa gca      768
 Ile His Arg Val Lys Lys Leu Thr Cys Arg Val Lys Ile Lys Glu Ala
                 245                 250                 255

 acg ggg ctg ccc tta aac ctc tca aat ttt gtc ttc tgt caa tac aca      816
 Thr Gly Leu Pro Leu Asn Leu Ser Asn Phe Val Phe Cys Gln Tyr Thr
             260                 265                 270

 ttc tgg gac cag tgt gag tct acg gtg gcc gcc ccg gtg gtg gac ccc      864
 Phe Trp Asp Gln Cys Glu Ser Thr Val Ala Ala Pro Val Val Asp Pro
         275                 280                 285

 gag gtg cct tca cca cag tcc aag gat gcc cag tac aca gtg acc ttc      912
 Glu Val Pro Ser Pro Gln Ser Lys Asp Ala Gln Tyr Thr Val Thr Phe
     290                 295                 300

 tcc cac tgt aag gac tat gtg gtg aat gta aca gaa gaa ttt ctg gag      960
 Ser His Cys Lys Asp Tyr Val Val Asn Val Thr Glu Glu Phe Leu Glu
 305                 310                 315                 320

 ttc att tca gat gga gca ctg gcc att gaa gta tgg ggc cac cgg tgt     1008
 Phe Ile Ser Asp Gly Ala Leu Ala Ile Glu Val Trp Gly His Arg Cys
                 325                 330                 335

 gct gga aat ggc agc tcc atc tgg gag gtc gat tct ctt cat gct aag     1056
 Ala Gly Asn Gly Ser Ser Ile Trp Glu Val Asp Ser Leu His Ala Lys
             340                 345                 350

 aca aga aca ctg cat gac agg tgg aat gaa gta acg cga aga ata gaa     1104
 Thr Arg Thr Leu His Asp Arg Trp Asn Glu Val Thr Arg Arg Ile Glu
         355                 360                 365

 atg tgg atc tcc ata tta gaa ttg aat gag tta gga gag tat gct gca     1152
 Met Trp Ile Ser Ile Leu Glu Leu Asn Glu Leu Gly Glu Tyr Ala Ala
     370                 375                 380

 gtg gaa ctt cat cag gca aaa gat gtc aac aca gga ggc atc ttt caa     1200
 Val Glu Leu His Gln Ala Lys Asp Val Asn Thr Gly Gly Ile Phe Gln
 385                 390                 395                 400

 ctt aga cag ggt cat tcc cgt aga gta caa gtc acg gtg aaa cct gtg     1248
 Leu Arg Gln Gly His Ser Arg Arg Val Gln Val Thr Val Lys Pro Val
                 405                 410                 415

 cag cat tca ggg aca ctg cca ctt atg gtt gaa gcc atc ctg tca gta     1296
 Gln His Ser Gly Thr Leu Pro Leu Met Val Glu Ala Ile Leu Ser Val
             420                 425                 430

 tcc atc ggc tgt gta act gcc agg tcc acc aaa ctc caa aga ggg ctg     1344
 Ser Ile Gly Cys Val Thr Ala Arg Ser Thr Lys Leu Gln Arg Gly Leu
         435                 440                 445

 gac agt tac cag aga gat gat gag gat ggt gat gat atg gat agt tat     1392
 Asp Ser Tyr Gln Arg Asp Asp Glu Asp Gly Asp Asp Met Asp Ser Tyr
     450                 455                 460

 cag gaa gaa gac tta aac tgc gta agg gag agg tgg tca gat gca ctc     1440
 Gln Glu Glu Asp Leu Asn Cys Val Arg Glu Arg Trp Ser Asp Ala Leu
 465                 470                 475                 480

 att aaa cga cga gaa tac ctg gat gaa cag ata aaa aaa gtc agc aat     1488
 Ile Lys Arg Arg Glu Tyr Leu Asp Glu Gln Ile Lys Lys Val Ser Asn
                 485                 490                 495

 aaa aca gag aaa aca gag gac gat gtg gag cgg gaa gcc cag ctt gtg     1536
 Lys Thr Glu Lys Thr Glu Asp Asp Val Glu Arg Glu Ala Gln Leu Val
             500                 505                 510

 gag cag tgg gta ggg ctg act gag gaa agg aat gct gtg ctg gtg cca     1584
 Glu Gln Trp Val Gly Leu Thr Glu Glu Arg Asn Ala Val Leu Val Pro
         515                 520                 525

 gcc cca ggc ggt ggg att cct ggg gca cct gcc gac tgg atc cca cct     1632
 Ala Pro Gly Gly Gly Ile Pro Gly Ala Pro Ala Asp Trp Ile Pro Pro
     530                 535                 540

 cct gga atg gaa acc cac ata cca gtt ctc ttc ctc gat ttg aat gcg     1680
 Pro Gly Met Glu Thr His Ile Pro Val Leu Phe Leu Asp Leu Asn Ala
 545                 550                 555                 560

 gat gac ctc agt gcc aat gag cag ctt gtt ggc ccc cat gca tcc ggc     1728
 Asp Asp Leu Ser Ala Asn Glu Gln Leu Val Gly Pro His Ala Ser Gly
                 565                 570                 575

 gtg aac tcc atc ctg ccc aag gag cat ggc agc cag ttt ttc tac ctg     1776
 Val Asn Ser Ile Leu Pro Lys Glu His Gly Ser Gln Phe Phe Tyr Leu
             580                 585                 590

 ccc atc ata aag cac agt gat gat gag gtt tca gcc aca gcc tct tgg     1824
 Pro Ile Ile Lys His Ser Asp Asp Glu Val Ser Ala Thr Ala Ser Trp
         595                 600                 605

 gat tcc tcg gtg cat gat tct gtt cac ttg aat agg gtc aca cca cag     1872
 Asp Ser Ser Val His Asp Ser Val His Leu Asn Arg Val Thr Pro Gln
     610                 615                 620

 aat gaa agg att tac cta att gtg aaa acc aca gtt caa ctc agc cac     1920
 Asn Glu Arg Ile Tyr Leu Ile Val Lys Thr Thr Val Gln Leu Ser His
 625                 630                 635                 640

 cct gct gct atg gag tta gta tta cga aaa cga att gca gcc aat att     1968
 Pro Ala Ala Met Glu Leu Val Leu Arg Lys Arg Ile Ala Ala Asn Ile
                 645                 650                 655

 tac aac aaa cag agt ttc acg cag agt ttg aag agg aga ata tcc ctg     2016
 Tyr Asn Lys Gln Ser Phe Thr Gln Ser Leu Lys Arg Arg Ile Ser Leu
             660                 665                 670

 aaa aat ata ttt tat tcc tgt ggt gta acc tat gaa ata gta tcc aat     2064
 Lys Asn Ile Phe Tyr Ser Cys Gly Val Thr Tyr Glu Ile Val Ser Asn
         675                 680                 685

 ata cca aag gca act gag gag ata gag gac cgg gaa acg ctg gct ctc     2112
 Ile Pro Lys Ala Thr Glu Glu Ile Glu Asp Arg Glu Thr Leu Ala Leu
     690                 695                 700

 ctg gca gca agg agt gaa aac gaa ggc aca tca gat ggg gag acg tac     2160
 Leu Ala Ala Arg Ser Glu Asn Glu Gly Thr Ser Asp Gly Glu Thr Tyr
 705                 710                 715                 720

 att gag aag tac act cga ggc gtg ctg cag gtg gaa aac att ctg agt     2208
 Ile Glu Lys Tyr Thr Arg Gly Val Leu Gln Val Glu Asn Ile Leu Ser
                 725                 730                 735

 ctt gaa cgg ctc cgg cag gcc gtc aca gtc aaa gaa gca ctt tcc acc     2256
 Leu Glu Arg Leu Arg Gln Ala Val Thr Val Lys Glu Ala Leu Ser Thr
             740                 745                 750

 aaa gcc cgg cac att cgg agg agc ctc agt aca cca aat gtt cat aat     2304
 Lys Ala Arg His Ile Arg Arg Ser Leu Ser Thr Pro Asn Val His Asn
         755                 760                 765

 gtc tct tcc agc cga ccg gac ctt tct ggc ttt gat gaa gat gac aag     2352
 Val Ser Ser Ser Arg Pro Asp Leu Ser Gly Phe Asp Glu Asp Asp Lys
     770                 775                 780

 ggt tgg cca gag aac cag ttg gac atg tct gac tat agc tcc agt tac     2400
 Gly Trp Pro Glu Asn Gln Leu Asp Met Ser Asp Tyr Ser Ser Ser Tyr
 785                 790                 795                 800

 caa gat gta gca tgt tat gga act tta ccc agg gat tct cct cga agg     2448
 Gln Asp Val Ala Cys Tyr Gly Thr Leu Pro Arg Asp Ser Pro Arg Arg
                 805                 810                 815

 aat aaa gaa ggt tgt aca tca gag act cct cat gcc tta acc gtc agc     2496
 Asn Lys Glu Gly Cys Thr Ser Glu Thr Pro His Ala Leu Thr Val Ser
             820                 825                 830

 cct ttt aaa gca ttc tct cct cag cca cca aag ttt ttc aag ccc cta     2544
 Pro Phe Lys Ala Phe Ser Pro Gln Pro Pro Lys Phe Phe Lys Pro Leu
         835                 840                 845

 atg cct gta aaa gag gag cat aag aaa agg ata gcc ctg gaa gca agg     2592
 Met Pro Val Lys Glu Glu His Lys Lys Arg Ile Ala Leu Glu Ala Arg
     850                 855                 860

 cct ctt cta agc cag gag agc atg cct cca cct cag gca cat aac cct     2640
 Pro Leu Leu Ser Gln Glu Ser Met Pro Pro Pro Gln Ala His Asn Pro
 865                 870                 875                 880

 ggc tgc att gta ccc tca gga agc aat ggc agc agc atg cca gta gaa     2688
 Gly Cys Ile Val Pro Ser Gly Ser Asn Gly Ser Ser Met Pro Val Glu
                 885                 890                 895

 cac aat agc aaa cgt gag aag aag att gac tct gag gag gaa gaa aat     2736
 His Asn Ser Lys Arg Glu Lys Lys Ile Asp Ser Glu Glu Glu Glu Asn
             900                 905                 910

 gag ctg gaa gct att aac agg aag cta ata agt tca cag cct tat gta     2784
 Glu Leu Glu Ala Ile Asn Arg Lys Leu Ile Ser Ser Gln Pro Tyr Val
         915                 920                 925

 cct gtg gag ttt gct gac ttc agt gtt tac aat gcc agc ttg gag aac     2832
 Pro Val Glu Phe Ala Asp Phe Ser Val Tyr Asn Ala Ser Leu Glu Asn
     930                 935                 940

 agg gaa tgg ttt tcc tct aaa gta gat ctg tca aac tca cgg gtc ttg     2880
 Arg Glu Trp Phe Ser Ser Lys Val Asp Leu Ser Asn Ser Arg Val Leu
 945                 950                 955                 960

 gag aaa gaa gtg tcc cgt agc cct acc acc agc agt att acc agt ggc     2928
 Glu Lys Glu Val Ser Arg Ser Pro Thr Thr Ser Ser Ile Thr Ser Gly
                 965                 970                 975

 tac ttt tcc cac agt gcc tcc aat gcc acc ctg tct gac atg gtg gtc     2976
 Tyr Phe Ser His Ser Ala Ser Asn Ala Thr Leu Ser Asp Met Val Val
             980                 985                 990

 cct tct agt gac agc tca gac cag ctg gcc att cag acg aag gat gca     3024
 Pro Ser Ser Asp Ser Ser Asp Gln Leu Ala Ile Gln Thr Lys Asp Ala
         995                1000                1005

 gac tcc acc gag cac tcc aca cca tcg ctt gtg cat gat ttc agg ccg     3072
 Asp Ser Thr Glu His Ser Thr Pro Ser Leu Val His Asp Phe Arg Pro
    1010                1015                1020

 tcc tca aac aaa gag ttg aca gaa gtc gaa aaa ggc ttg gta aag gac     3120
 Ser Ser Asn Lys Glu Leu Thr Glu Val Glu Lys Gly Leu Val Lys Asp
1025                1030                1035                1040

 aag ata att gtg gtg cca ctc aag gaa aac agt gcc tta gcc aaa ggg     3168
 Lys Ile Ile Val Val Pro Leu Lys Glu Asn Ser Ala Leu Ala Lys Gly
                1045                1050                1055

 agc cca tca tcc cag agc atc cct gag aaa aac tcc aaa tca ctg tgc     3216
 Ser Pro Ser Ser Gln Ser Ile Pro Glu Lys Asn Ser Lys Ser Leu Cys
            1060                1065                1070

 agg act ggc tca tgt tca gaa cta gat gcc tgc ccc agc aaa att agc     3264
 Arg Thr Gly Ser Cys Ser Glu Leu Asp Ala Cys Pro Ser Lys Ile Ser
        1075                1080                1085

 cag cca gcc agg gga ttc tgc ccc agg gag gtg acg gta gaa cac acc     3312
 Gln Pro Ala Arg Gly Phe Cys Pro Arg Glu Val Thr Val Glu His Thr
    1090                1095                1100

 acc aac atc ctt gaa gac cat tct ttc aca gaa ttt atg gga gtg tca     3360
 Thr Asn Ile Leu Glu Asp His Ser Phe Thr Glu Phe Met Gly Val Ser
1105                1110                1115                1120

 gag gga aaa gat ttt gat ggt ttg aca gat tct tct gct gga gag ctt     3408
 Glu Gly Lys Asp Phe Asp Gly Leu Thr Asp Ser Ser Ala Gly Glu Leu
                1125                1130                1135

 tcc agt agg agg agt cta cca aat aaa aca ggc ggc aag act gtc tcc     3456
 Ser Ser Arg Arg Ser Leu Pro Asn Lys Thr Gly Gly Lys Thr Val Ser
            1140                1145                1150

 gat ggg ctc cac cac ccc agc cag ctg cat tcc aag tta gag aat gac     3504
 Asp Gly Leu His His Pro Ser Gln Leu His Ser Lys Leu Glu Asn Asp
        1155                1160                1165

 cag gta ata att cca gag gca gcc ttt tgg gtt ctg tgc tgt caa tga     3552
 Gln Val Ile Ile Pro Glu Ala Ala Phe Trp Val Leu Cys Cys Gln 
    1170                1175                1180

 gtatgtctaa ctgtatgtca accccagagg cccttcaccg caacaactcg gtaggaaaga   3612

 tgcatccccc tgtttgtgac agcaaagatg agcccacaga gaagcaggct catttcctgc   3672

 acagctgtgt                                                          3682




      <210> 27
      <211> 1200
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (258)..(1082)

      <220>
      <221> misc_feature
      <222> (1)...(1200)
      <223> n = a,t,c or g

      <400> 27
 gagagggttc ccggatacac cttgcgaaga atgccgcact ctccgccact cattccccac     60

 tcaccggcac ccgctaaacc ttcagcctga aattttcctc cgaagganag cagagcagag    120

 gaagaactac caagtgctac actcaaagcc tgccgtcgca gtgagcgcga cctccaaact    180

 gaggcatttt tgttccggcg aaatccctcc cactcaggaa agtccctaga aagagagcgc    240

 aggccctggg gtatcac   atg acc act tcc cgg aag cgc agc aga ccc gct     290
                      Met Thr Thr Ser Arg Lys Arg Ser Arg Pro Ala
                        1               5                  10

 caa ctt cat cct ggg ttg agg cgg agg aga act tcc aga att atg gcg      338
 Gln Leu His Pro Gly Leu Arg Arg Arg Arg Thr Ser Arg Ile Met Ala
              15                  20                  25

 aag tcc ggg ctg agg cag gac ccg cag agc aca gct gca gcc act gtg      386
 Lys Ser Gly Leu Arg Gln Asp Pro Gln Ser Thr Ala Ala Ala Thr Val
          30                  35                  40

 cta aag cgg gca gta gaa cta gat tcg gag tcg cgg tat ccg cag gct      434
 Leu Lys Arg Ala Val Glu Leu Asp Ser Glu Ser Arg Tyr Pro Gln Ala
      45                  50                  55

 ctg gtg tgt tac caa gag ggg att gat ctg ctc ctg cag gtt ctg aaa      482
 Leu Val Cys Tyr Gln Glu Gly Ile Asp Leu Leu Leu Gln Val Leu Lys
  60                  65                  70                  75

 ggt acc aaa gat aat act aag aga tgt aat ctc aga gaa aaa att tcc      530
 Gly Thr Lys Asp Asn Thr Lys Arg Cys Asn Leu Arg Glu Lys Ile Ser
                  80                  85                  90

 aaa tac atg gac aga gcg gaa aac ata aag aag tac ttg gac caa gaa      578
 Lys Tyr Met Asp Arg Ala Glu Asn Ile Lys Lys Tyr Leu Asp Gln Glu
              95                 100                 105

 aaa gaa gat gga aaa tat cac aag caa att aaa ata gaa gag aat gca      626
 Lys Glu Asp Gly Lys Tyr His Lys Gln Ile Lys Ile Glu Glu Asn Ala
         110                 115                 120

 aca ggt ttc agt tat gag tca ctt ttt cgc gaa tac ctt aat gag aca      674
 Thr Gly Phe Ser Tyr Glu Ser Leu Phe Arg Glu Tyr Leu Asn Glu Thr
     125                 130                 135

 gtt aca gaa gtt tgg ata gaa gat cct tat att aga cat act cat cag      722
 Val Thr Glu Val Trp Ile Glu Asp Pro Tyr Ile Arg His Thr His Gln
 140                 145                 150                 155

 ctg tat aac ttt ctt cga ttt tgt gag atg ctt att aag aga cca tgt      770
 Leu Tyr Asn Phe Leu Arg Phe Cys Glu Met Leu Ile Lys Arg Pro Cys
                 160                 165                 170

 aaa gta aaa act att cac ctt ctc acc tct ctg gat gaa ggc att gag      818
 Lys Val Lys Thr Ile His Leu Leu Thr Ser Leu Asp Glu Gly Ile Glu
             175                 180                 185

 caa gtg cag caa agt aga ggc ctg caa gaa ata gaa gag tca ctc agg      866
 Gln Val Gln Gln Ser Arg Gly Leu Gln Glu Ile Glu Glu Ser Leu Arg
         190                 195                 200

 agt cac gga gtg ctg ttg gaa gtt caa tac tct tct tca ata cat gac      914
 Ser His Gly Val Leu Leu Glu Val Gln Tyr Ser Ser Ser Ile His Asp
     205                 210                 215

 cga gaa att agg ttc aac aat gga tgg atg att aag att gga agg gga      962
 Arg Glu Ile Arg Phe Asn Asn Gly Trp Met Ile Lys Ile Gly Arg Gly
 220                 225                 230                 235

 ctt gat tat ttt aag aaa cca cag agt cgt ttt tcc ctt gga tat tgt     1010
 Leu Asp Tyr Phe Lys Lys Pro Gln Ser Arg Phe Ser Leu Gly Tyr Cys
                 240                 245                 250

 gat ttt gat tta aga cca tgt cat gaa aca aca gta gac att ttt cat     1058
 Asp Phe Asp Leu Arg Pro Cys His Glu Thr Thr Val Asp Ile Phe His
             255                 260                 265

 aag aag cat aca aaa aat ata tga tgggtggtag cctaatttgt attatgtcta    1112
 Lys Lys His Thr Lys Asn Ile 
         270

 ctttaagtga atattggatt ttttttaaaa gatcactttt ataatgtatg aatttaacaa   1172

 taaactttta tatttctaaa aaaaaaaa                                      1200




      <210> 28
      <211> 2082
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (37)..(801)

      <400> 28
 cgggtcgacg atttcgtcgg gcttcgggca cttgac  atg gcg gca gtg gcg gcg      54
                                          Met Ala Ala Val Ala Ala
                                            1               5

 act gca gca gcg aag ggg aat ggg ggc ggc ggt ggc agg gcc ggg gcc      102
 Thr Ala Ala Ala Lys Gly Asn Gly Gly Gly Gly Gly Arg Ala Gly Ala
              10                  15                  20

 ggg gac gcc agc ggc acg cgg aag aag aag ggc ccg ggg ccc ctg gcc      150
 Gly Asp Ala Ser Gly Thr Arg Lys Lys Lys Gly Pro Gly Pro Leu Ala
          25                  30                  35

 acg gcg tac ctg gtc atc tac aat gtg gtg atg aca gcc ggg tgg ctg      198
 Thr Ala Tyr Leu Val Ile Tyr Asn Val Val Met Thr Ala Gly Trp Leu
      40                  45                  50

 gtt ata gcg gtt ggt ctg gtc cga gca tac ctg gct aag ggt agc tac      246
 Val Ile Ala Val Gly Leu Val Arg Ala Tyr Leu Ala Lys Gly Ser Tyr
  55                  60                  65                  70

 cat agc ctt tat tat tca att gaa aag cct ttg aaa ttc ttt caa act      294
 His Ser Leu Tyr Tyr Ser Ile Glu Lys Pro Leu Lys Phe Phe Gln Thr
                  75                  80                  85

 gga gcc tta ttg gag att tta cat tgt gct ata gga att gtt cca tct      342
 Gly Ala Leu Leu Glu Ile Leu His Cys Ala Ile Gly Ile Val Pro Ser
              90                  95                 100

 tct gtt gtc ctg act tct ttc cag gtg atg tca aga gtt ttt cta ata      390
 Ser Val Val Leu Thr Ser Phe Gln Val Met Ser Arg Val Phe Leu Ile
         105                 110                 115

 tgg gca gta aca cat agc gtc aaa gag gta cag agt gaa gac agt gtc      438
 Trp Ala Val Thr His Ser Val Lys Glu Val Gln Ser Glu Asp Ser Val
     120                 125                 130

 ctc ctg ttt gtt att gca tgg acg atc acg gaa atc atc cgt tac tcc      486
 Leu Leu Phe Val Ile Ala Trp Thr Ile Thr Glu Ile Ile Arg Tyr Ser
 135                 140                 145                 150

 ttt tat aca ttc agt cta tta aac cat ctg cct tac ctc atc aaa tgg      534
 Phe Tyr Thr Phe Ser Leu Leu Asn His Leu Pro Tyr Leu Ile Lys Trp
                 155                 160                 165

 gcc agg tac aca ctt ttc att gtg ctg tac cca atg gga gtg tca gga      582
 Ala Arg Tyr Thr Leu Phe Ile Val Leu Tyr Pro Met Gly Val Ser Gly
             170                 175                 180

 gaa ctg ctc aca ata tat gca gct ctg ccc ttt gtc aga caa gct ggc      630
 Glu Leu Leu Thr Ile Tyr Ala Ala Leu Pro Phe Val Arg Gln Ala Gly
         185                 190                 195

 cta tat tcc atc agt tta ccc aac aaa tac aat ttc tct ttt gac tac      678
 Leu Tyr Ser Ile Ser Leu Pro Asn Lys Tyr Asn Phe Ser Phe Asp Tyr
     200                 205                 210

 tat gca ttc ctg att cta ata atg atc tcc tac att cca att ttt ccc      726
 Tyr Ala Phe Leu Ile Leu Ile Met Ile Ser Tyr Ile Pro Ile Phe Pro
 215                 220                 225                 230

 cag tta tac ttc cac atg ata cac cag aga aga aag atc ctt tct cat      774
 Gln Leu Tyr Phe His Met Ile His Gln Arg Arg Lys Ile Leu Ser His
                 235                 240                 245

 act gaa gaa cac aag aaa ttt gaa tag ttcct gctttctgca cctcccacca      826
 Thr Glu Glu His Lys Lys Phe Glu 
             250

 aaacaaactt ttcaatgatc aaaaaatgct gcagattttt tgagttccca atacgtttca    886

 tagaaaataa gtaagaacta tttttaaaat attcaaacaa aactaaaaca aaaatccagt    946

 gtcacatggg cctgagattt tattttagaa aaaggttgtt acataaaaca ccctggccag   1006

 ttcatttcag catgctcttt caaccagaag ttcttaatat ttatgatggc actagaaagg   1066

 gatttggcat tttatgtcct tctgtgtcct tcatgtatct gatcaatgaa gacctgtaac   1126

 actaagtact tgagagttac agtctgaata atgaagtcgt accagctgaa tagcccagct   1186

 tgcagtatag ttatgtttca gtctgcagtg tgtttagcat tcccttgtca aagtgcttga   1246

 ctgcatgctg gaaactttgt atttttgaag cggcaaactc tgttctctgg aatgctctga   1306

 agttatggct gggacctatc ccctcacatc taatgaatga attataaaat gtatatgtct   1366

 atgaagcttc ggggtagtgc ctgtaatcag aaaacaactt agaacccttt tgtttgtttc   1426

 caattgagtc attactgcct gccactaaga aacgtgcttg aatctaataa gtatgtgtgt   1486

 accgtaaaga atatatctta tctggagctc agcctcaatc atgtcttaac aaaatgacag   1546

 gtctcagaaa gggggagctc aatagctcaa aagtgacaag tccttttcac agcaccgttc   1606

 tcagaacacc tctgagtaac gtgtttgcca gtagctattc tcactgatgc actgatggcc   1666

 ctgaagaagc ggatccagtc acataggaaa ggaggctgtg ttagtgaaag cacatggaag   1726

 gtgttgcttt agaaaggtag tcaggaaaaa cattcaggaa tagatttata caccattatt   1786

 gttttatttt taaattttca ttcactcttc tgtttggata cttttgctaa ttaacgtcct   1846

 atgttaattt ccaccaagct ataagtccat agtcagtaaa acattcccct tgggctgtca   1906

 tgagctaaaa gcagtgtcat ctccgcatgt tggagcagcc aagaaatagt ttggtactac   1966

 cgacattgtc taatccatgt cacatcctca tacaatttaa ttgctcaacc atgcatttaa   2026

 aactcctcaa gaaaggattg gtactgcaac tgtaggtaaa ctgaaaaaaa aaaaaa       2082




      <210> 29
      <211> 1581
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (101)..(790)

      <400> 29
 tttcgtgggc cggttgctaa gacttggcga agcgctgcgc tcgcgcccgg atccctcagg     60

 cggctgcagg cttcagcctg cgctggttgg tgaaacagag  atg tca gaa aag gag     115
                                              Met Ser Glu Lys Glu
                                                1               5

 aac aac ttc ccg cca ctg ccc aag ttc atc cct gtg aag ccc tgc ttc      163
 Asn Asn Phe Pro Pro Leu Pro Lys Phe Ile Pro Val Lys Pro Cys Phe
                  10                  15                  20

 tac cag aac ttc tcc gac gag atc cca gtg gag cac cag gtc ctg gtg      211
 Tyr Gln Asn Phe Ser Asp Glu Ile Pro Val Glu His Gln Val Leu Val
              25                  30                  35

 aag agg atc tac cgg ctg tgg atg ttt tac tgc gcc acc ctc ggc gtc      259
 Lys Arg Ile Tyr Arg Leu Trp Met Phe Tyr Cys Ala Thr Leu Gly Val
          40                  45                  50

 aac ctc att gcc tgc ctg gcc tgg tgg atc ggc gga ggc tcg ggg acc      307
 Asn Leu Ile Ala Cys Leu Ala Trp Trp Ile Gly Gly Gly Ser Gly Thr
      55                  60                  65

 aac ttc ggc ctg gcc ttc gtg tgg ctg ctc ctg ttc acg cct tgc ggc      355
 Asn Phe Gly Leu Ala Phe Val Trp Leu Leu Leu Phe Thr Pro Cys Gly
  70                  75                  80                  85

 tac gtg tgc tgg ttc cgg cct gtc tac aag gcc ttc cga gcc gac agc      403
 Tyr Val Cys Trp Phe Arg Pro Val Tyr Lys Ala Phe Arg Ala Asp Ser
                  90                  95                 100

 tcc ttt aat ttc atg gcg ttt ttc ttc atc ttc gga gcc cag ttt gtc      451
 Ser Phe Asn Phe Met Ala Phe Phe Phe Ile Phe Gly Ala Gln Phe Val
             105                 110                 115

 ctg acc gtc atc cag gcg att ggc ttc tcc ggc tgg ggc gcg tgc ggc      499
 Leu Thr Val Ile Gln Ala Ile Gly Phe Ser Gly Trp Gly Ala Cys Gly
         120                 125                 130

 tgg ctg tcg gca att gga ttc ttc cag tac agc ccg ggc gct gcc gtg      547
 Trp Leu Ser Ala Ile Gly Phe Phe Gln Tyr Ser Pro Gly Ala Ala Val
     135                 140                 145

 gtc atg ctg ctt cca gcc atc atg ttc tcc gtg tcg gct gcc atg atg      595
 Val Met Leu Leu Pro Ala Ile Met Phe Ser Val Ser Ala Ala Met Met
 150                 155                 160                 165

 gcc atc gcg atc atg aag gtg cac agg atc tac cga ggg gct ggc gga      643
 Ala Ile Ala Ile Met Lys Val His Arg Ile Tyr Arg Gly Ala Gly Gly
                 170                 175                 180

 agc ttc cag aag gca cag acg gag tgg aac acg ggc act tgg cgg aac      691
 Ser Phe Gln Lys Ala Gln Thr Glu Trp Asn Thr Gly Thr Trp Arg Asn
             185                 190                 195

 cca ccg tcg agg gag gcc cag tac aac aac ttc tca ggc aac agc ctg      739
 Pro Pro Ser Arg Glu Ala Gln Tyr Asn Asn Phe Ser Gly Asn Ser Leu
         200                 205                 210

 ccc gag tac ccc act gtg ccc agc tac ccg ggc agt ggc cag tgg cct      787
 Pro Glu Tyr Pro Thr Val Pro Ser Tyr Pro Gly Ser Gly Gln Trp Pro
     215                 220                 225

 tag ggag cctgccctgc ccccaccgcc caccacctcc tccccttcat tcctgctgct      844
 


 acccctggtc ccgagggctg ggagtacctg gggccccatc cccccagctg ggatggtgga    904

 agccggtggt ggccacggac cgcccccctc ctgccagggc cacagaaccc gtgttcatct    964

 catccgagag cggagttcct cacaagcact ccccagcagc ccttggcctc tgccgtccac   1024

 aggacgccct cttgctcccg gaaacgtgtg gtcacccgcc gtccactgca cggctggtac   1084

 ggccttgtct tcaggtctcg aggcctgact ccgggggaca ggtggcagca ggtcggccgc   1144

 cctcccgtcc tccaagagct gctggcgctg aggtcagagc gggtctgatg gggagctccg   1204

 tctcaccggc cacccgccgt caccatggca gatgcccttg gccggaacta ataagaggcg   1264

 tcggggccag cttccggtcc cctgcagtga tagagggctt ggtgcctagc tgagtcctcg   1324

 ctgtccccgc catcccctga tctgtgcggc tccagcctcg ccccctcccc acgtgcacca   1384

 tacctgggga gttcctggtc cagggtatcc tggggccacc ctccctgcct ccaaaacagg   1444

 gatccctggc aggctgtctt tccacgcccc tgagttcaga gtcggggacc caggccaggt   1504

 cgggagcaca gccgctcccc aaacccagca aaccggcaga gagccggttt cccagcagcc   1564

 ggagccctgc aggagag                                                  1581




      <210> 30
      <211> 2618
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (321)..(869)

      <400> 30
 acaattacac ctcgctttat taacattaaa ttttttaaat ttacaaaagg atcagcccat     60

 gacagcagct gaacaacact taacaggaca aaaggaaaat aaaaatgcca gacaagatat    120

 acagtggagg gatgcacata caaagagttg ggaaaaagga aaaataatta catggggaag    180

 aggatttgct tctgtctctc caagtgacaa tcaggtgcct ctgtgggtgc ccaccaaaca    240

 tctgaaggtc tatcatgagc cacaccagga agagaggact ctgggaagag ccagaactcc    300

 ctatacgagt gatggcatga    atg aaa atc tca gag aca aag gaa aag acc     350
                          Met Lys Ile Ser Glu Thr Lys Glu Lys Thr
                            1               5                  10

 aag aat act cac cag gca gac cct cca aca tgg gga caa atc agg aaa      398
 Lys Asn Thr His Gln Ala Asp Pro Pro Thr Trp Gly Gln Ile Arg Lys
                  15                  20                  25

 ctg gca cag atg gca gag gac aat ctg aga gca cag aac aaa tca aaa      446
 Leu Ala Gln Met Ala Glu Asp Asn Leu Arg Ala Gln Asn Lys Ser Lys
              30                  35                  40

 aca act agt aac cta atg gtg gct atg atg gtg gta ctt act gtg gcg      494
 Thr Thr Ser Asn Leu Met Val Ala Met Met Val Val Leu Thr Val Ala
          45                  50                  55

 gta agc ctc cct act gta aaa gca act caa aat ttt act tat tgg act      542
 Val Ser Leu Pro Thr Val Lys Ala Thr Gln Asn Phe Thr Tyr Trp Thr
      60                  65                  70

 tat gtc cca ttt cct cct tta att agg tct gtg agt tgg atg gac cct      590
 Tyr Val Pro Phe Pro Pro Leu Ile Arg Ser Val Ser Trp Met Asp Pro
  75                  80                  85                  90

 att att gag gtg tac aac aat gac aga acc tcg atg cct gag ccc ata      638
 Ile Ile Glu Val Tyr Asn Asn Asp Arg Thr Ser Met Pro Glu Pro Ile
                  95                 100                 105

 gat aac aga gtg ccg atg cat cct aat gag gaa ggg atg aaa atg aat      686
 Asp Asn Arg Val Pro Met His Pro Asn Glu Glu Gly Met Lys Met Asn
             110                 115                 120

 ata tca ata gga tat aaa tat cct cca ata tgc cta gga cct gct gct      734
 Ile Ser Ile Gly Tyr Lys Tyr Pro Pro Ile Cys Leu Gly Pro Ala Ala
         125                 130                 135

 gga tgc tta caa att ggc aca caa gta tgg ttg gca gta atc cct gga      782
 Gly Cys Leu Gln Ile Gly Thr Gln Val Trp Leu Ala Val Ile Pro Gly
     140                 145                 150

 aaa aat aaa tca cag gct act tta tat atg att tca ggg caa agt tta      830
 Lys Asn Lys Ser Gln Ala Thr Leu Tyr Met Ile Ser Gly Gln Ser Leu
 155                 160                 165                 170

 aaa tat aac cat tcc agc cct gaa act cag cag ttc tga ccagacaaac       879
 Lys Tyr Asn His Ser Ser Pro Glu Thr Gln Gln Phe 
                 175                 180

 tcgaatgtaa acaaaataga gtttggtttg aaggtgtgga cgcttggcat tggggaaatt    939

 gtgtagcaag taaggctggg gtgctacaaa ataattccta tggaatcgtc attgactggt    999

 cccctaaggg gatttttaag aaaaattgca ctgaagggcc ttcttataaa ataagctgat   1059

 ggactcattg gaaagagaac catacacggt acattcagac ggaagctgat gttcctatta   1119

 tatggagccc tggtggcatt atcaccccta ttccaaaaat gatatctcct gccataggac   1179

 aggaacattc aggattatgg aaattagcta tggctcaaag ttcaatcaca atttgggagg   1239

 gtaaatataa taagtataaa ggggagggag gtaaatataa atatgttctc tcttttcttt   1299

 ctaacaggac cttttggaat caaaattgtg tccgaccacc ttttacgtta gcagtaggaa   1359

 atgttactct tgatataaac acacacttta tttcatgccc cgcatgtcat ttgtttacct   1419

 gtattagttc aacctttaat aaaaatcaga ctgtcctaat aattaaagcc agggaaggag   1479

 tctggatacc tatgtcttta aatagaccgt gggcggcatc tccatccatt catacagtaa   1539

 atgaaatcct taaaaaactc ttatcccgtt caaaaagatt tatagttgct cttatatttg   1599

 ctataattgg cctcactgca gttaccacca ctgctgcagt agctagtgtg gctttacact   1659

 catctgtgca aactgtcaaa tttgttgata aatggaaaaa gaattctatg aaattatgga   1719

 gctctcaggc ccaaacagat caaaatatag ttagtcaaat taatgatctc cctcagacag   1779

 taatttggat gggggattgc atcataagtt tagaaactag aattcaaatg caatgtgact   1839

 ggaatacatc cgatttttgc gttactcctc atagttagaa tgaaacagaa caccaatggg   1899

 aaattaaatg ccatctagtg ggcagagagg aaaatctcac ccttgatatt gtaaaagtaa   1959

 aagagcaggt ttttgaagcc tctcaggctc acttaaccct gctccctgga actgatattt   2019

 tcagcgaggc agccaatggg ttgtctgcaa tcaattctct taaatggatt aagaccactg   2079

 gaaactctac acttgtaaat tttgttctaa taattatatg cttgtgctgt ctccttttaa   2139

 tctacagatg cggaagccgc ttctggagag aaagccgctg ccaagaacaa gcaatgatag   2199

 ctgtggcggt tttgcaggac aaaaaaggga gacatgttgg cagaagagct gaggcagggc   2259

 tcgtttttct gacataatgt aaaagagtct tggaacatgt cctgggtcca gggtctaaaa   2319

 cccctcatga cctttggaac accaaactct gtgccaaagg gtggaaggct gccctgccgc   2379

 agtacaatct aaacccaggg tatgaaaccc cttgtggctt ggagagaacc cagggctcag   2439

 ggcataaaac cctctgtagc ctttggagtg tgtccagact cactggcccc ttgcactttg   2499

 ttctcccaag atcataaatt gattgtatct tgaattagaa gaacctattc tcccttatct   2559

 caagtagcag agcatatgct aacccatcac agatacgctt gatgcaccgc tttctaccc    2618




      <210> 31
      <211> 844
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(788)

      <400> 31
 gggcggggct gcgggagtga gcctagagtc cggctgttgg ctagagtggg cgcggatctg     60

 gtgtggggaa ggcggcggga ctcaggcctg cctgcgaagc attgtcctac ata   atg     116
                                                              Met
                                                                1

 gta gag gac gaa ctg gca ctt ttc gat aaa agc ata aat gaa ttt tgg      164
 Val Glu Asp Glu Leu Ala Leu Phe Asp Lys Ser Ile Asn Glu Phe Trp
               5                  10                  15

 aat aaa ttc aaa agt acg gac acc tcc tgt cag atg gcg gga cta aga      212
 Asn Lys Phe Lys Ser Thr Asp Thr Ser Cys Gln Met Ala Gly Leu Arg
          20                  25                  30

 gat acc tac aag gat tcc atc aaa gca ttt gca gaa aag ctg tct gtg      260
 Asp Thr Tyr Lys Asp Ser Ile Lys Ala Phe Ala Glu Lys Leu Ser Val
      35                  40                  45

 aaa tta aag gaa gaa gaa cga atg gtt gag atg ttt ctg gaa tat caa      308
 Lys Leu Lys Glu Glu Glu Arg Met Val Glu Met Phe Leu Glu Tyr Gln
  50                  55                  60                  65

 aat cag atc agc agg caa aat aag ctc att caa gaa aaa aag gat aac      356
 Asn Gln Ile Ser Arg Gln Asn Lys Leu Ile Gln Glu Lys Lys Asp Asn
                  70                  75                  80

 ttg tta aaa ttg att gct gaa gta aaa ggc aaa aag cag gaa ttg gaa      404
 Leu Leu Lys Leu Ile Ala Glu Val Lys Gly Lys Lys Gln Glu Leu Glu
              85                  90                  95

 gta ctg act gca aat atc cag gat ctt aag gaa gaa tat tct agg aag      452
 Val Leu Thr Ala Asn Ile Gln Asp Leu Lys Glu Glu Tyr Ser Arg Lys
         100                 105                 110

 aag gaa act att tct act gct aat aaa gcg aat gca gag agg ttg aaa      500
 Lys Glu Thr Ile Ser Thr Ala Asn Lys Ala Asn Ala Glu Arg Leu Lys
     115                 120                 125

 agg ctg cag aaa tct gca gac ttg tat aaa gat cga ctt gga cta gaa      548
 Arg Leu Gln Lys Ser Ala Asp Leu Tyr Lys Asp Arg Leu Gly Leu Glu
 130                 135                 140                 145

 att cga aaa att tat ggt gag aaa ttg cag ttt att ttc act aat att      596
 Ile Arg Lys Ile Tyr Gly Glu Lys Leu Gln Phe Ile Phe Thr Asn Ile
                 150                 155                 160

 gac cct aag aat cct gag agc cca ttt atg ttt tcc tta cat ctc aat      644
 Asp Pro Lys Asn Pro Glu Ser Pro Phe Met Phe Ser Leu His Leu Asn
             165                 170                 175

 gaa gca agg gac tat gaa gtg tca gat agt gcc cct cat ctt gag ggc      692
 Glu Ala Arg Asp Tyr Glu Val Ser Asp Ser Ala Pro His Leu Glu Gly
         180                 185                 190

 cta gca gaa ttt caa gag aat gta agg aag acc aac aat ttt tca gct      740
 Leu Ala Glu Phe Gln Glu Asn Val Arg Lys Thr Asn Asn Phe Ser Ala
     195                 200                 205

 ttt ctt gcc aat gtt cgg aaa gct ttt act gcc acg gtt tat aat taa      788
 Phe Leu Ala Asn Val Arg Lys Ala Phe Thr Ala Thr Val Tyr Asn 
 210                 215                 220

 catacaaata gtgtatataa aaacggttta tttttcttct ctaaaaaaaa aaaaaa        844




      <210> 32
      <211> 1084
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(1004)

      <400> 32
 gacacccctc tctgtgactc agtctctgag cgttttaata cgatggtgtc cccgcgggat     60

 caaacttcag cgtcacagct gaggactggc ttcgtggtcc ctgatgggag agc   atg     116
                                                              Met
                                                                1

 aac agg tgg tat gtg aag ccc ttg gag acc agc tct tcc aaa gtc aaa      164
 Asn Arg Trp Tyr Val Lys Pro Leu Glu Thr Ser Ser Ser Lys Val Lys
               5                  10                  15

 gcc aag acc att gtg atg att ccc gac tcc cag aag ctc ctg cga tgt      212
 Ala Lys Thr Ile Val Met Ile Pro Asp Ser Gln Lys Leu Leu Arg Cys
          20                  25                  30

 gaa ctt gag tca ctc aag agc cag tta cag gcc cag acc aag gct ttc      260
 Glu Leu Glu Ser Leu Lys Ser Gln Leu Gln Ala Gln Thr Lys Ala Phe
      35                  40                  45

 gag ttc ctg aac cac tca gtg acc atg ttg gag aag gag agc tgc ttg      308
 Glu Phe Leu Asn His Ser Val Thr Met Leu Glu Lys Glu Ser Cys Leu
  50                  55                  60                  65

 cag caa atc aag att cag cag ctt gaa gag gtg ctg agc ccc aca ggc      356
 Gln Gln Ile Lys Ile Gln Gln Leu Glu Glu Val Leu Ser Pro Thr Gly
                  70                  75                  80

 cgc cag gga gag aag gag gag cac aag tgg ggc atg gag cag ggc cgg      404
 Arg Gln Gly Glu Lys Glu Glu His Lys Trp Gly Met Glu Gln Gly Arg
              85                  90                  95

 cag gag ctg tat ggg gcc ctg acc caa ggc ctt cag ggg ctg gag aag      452
 Gln Glu Leu Tyr Gly Ala Leu Thr Gln Gly Leu Gln Gly Leu Glu Lys
         100                 105                 110

 acc ctg cgt gac agt gag gag atg cag cgg gcc cgc acc act cgc tgc      500
 Thr Leu Arg Asp Ser Glu Glu Met Gln Arg Ala Arg Thr Thr Arg Cys
     115                 120                 125

 ctg cag ctg ctg gcc cag gag atc cgg gac agc aag aag ttc ctg tgg      548
 Leu Gln Leu Leu Ala Gln Glu Ile Arg Asp Ser Lys Lys Phe Leu Trp
 130                 135                 140                 145

 gag gag ctg gaa ctg gtg cgg gag gag gtg acc ttc atc tat cag aag      596
 Glu Glu Leu Glu Leu Val Arg Glu Glu Val Thr Phe Ile Tyr Gln Lys
                 150                 155                 160

 ctc caa gcg cag gag gat gag atc tca gag aac ttg gtg aac att cag      644
 Leu Gln Ala Gln Glu Asp Glu Ile Ser Glu Asn Leu Val Asn Ile Gln
             165                 170                 175

 aaa atg cag aaa acg cag gtg aaa tgc cgc aaa atc ctg acc aag atg      692
 Lys Met Gln Lys Thr Gln Val Lys Cys Arg Lys Ile Leu Thr Lys Met
         180                 185                 190

 aag cag cag ggt cat gag aca gcc gcc tgt ccg gag act gaa gag ata      740
 Lys Gln Gln Gly His Glu Thr Ala Ala Cys Pro Glu Thr Glu Glu Ile
     195                 200                 205

 ccg cag gga gcc agt ggc tgc tgg aag gat gac ctc cag aag gaa ctg      788
 Pro Gln Gly Ala Ser Gly Cys Trp Lys Asp Asp Leu Gln Lys Glu Leu
 210                 215                 220                 225

 agt gat ata tgg tct gct gtg cac gtg ctg cag aac tcc ata gac agc      836
 Ser Asp Ile Trp Ser Ala Val His Val Leu Gln Asn Ser Ile Asp Ser
                 230                 235                 240

 ctc act ttg tgc tcg ggg gcc tgt ccc aag gcc tcg agc cta aga ggc      884
 Leu Thr Leu Cys Ser Gly Ala Cys Pro Lys Ala Ser Ser Leu Arg Gly
             245                 250                 255

 cac aag ggg cac cag tgc ctg agc cct cca ctc ccc tcc tgg gac tct      932
 His Lys Gly His Gln Cys Leu Ser Pro Pro Leu Pro Ser Trp Asp Ser
         260                 265                 270

 gac tcc gac tct gac cag gac ctc tcc cag cca cct ttc agc aag agc      980
 Asp Ser Asp Ser Asp Gln Asp Leu Ser Gln Pro Pro Phe Ser Lys Ser
     275                 280                 285

 ggc cgc tcc ttc cca ccc gct tga gcagccggga ctgctctccc tgaagacccc    1034
 Gly Arg Ser Phe Pro Pro Ala 
 290                 295

 tccagagaga aaataaacta gcccagaccc tcctctaaaa aaaaaaaaaa              1084




      <210> 33
      <211> 225
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (49)..(201)

      <400> 33
 acttgatgaa atgaaaaagg gcaatgccga gaaaaaaccc cctagttc atg agg ccg      57
                                                      Met Arg Pro
                                                        1

 act ccg gca ctg cct tct gga tac act gat tgc acc act ctt gag ggc      105
 Thr Pro Ala Leu Pro Ser Gly Tyr Thr Asp Cys Thr Thr Leu Glu Gly
       5                  10                  15

 ctc ctt tac cat ctc aac caa agg ctt ttg ttt tca tct cca acc tca      153
 Leu Leu Tyr His Leu Asn Gln Arg Leu Leu Phe Ser Ser Pro Thr Ser
  20                  25                  30                  35

 gcg att ttc gtc ttg gct aga ccc ggt gct gcc tta gga caa aaa tag      201
 Ala Ile Phe Val Leu Ala Arg Pro Gly Ala Ala Leu Gly Gln Lys 
                  40                  45                  50

 ggccacaagt taagaactac ctat                                           225




      <210> 34
      <211> 830
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(559)

      <220>
      <221> misc_feature
      <222> (1)...(830)
      <223> n = a,t,c or g

      <400> 34
 aaggatcctt aattaaatta atcccccccc ccctgtgctc  atg ctc gct gca ggg      55
                                              Met Leu Ala Ala Gly
                                                1               5

 gtc gga ggt cag ggc gag cgt ctc gca ggc cgt agg agg aag atg gcg      103
 Val Gly Gly Gln Gly Glu Arg Leu Ala Gly Arg Arg Arg Lys Met Ala
                  10                  15                  20

 gtg gag tcg cgc gtt acc cag gag gaa att aag aag gag cca gag aaa      151
 Val Glu Ser Arg Val Thr Gln Glu Glu Ile Lys Lys Glu Pro Glu Lys
              25                  30                  35

 ccg atc gac cgc gag aag aca tgc cca ctg ttg cta cgg gtc ttc acc      199
 Pro Ile Asp Arg Glu Lys Thr Cys Pro Leu Leu Leu Arg Val Phe Thr
          40                  45                  50

 acc aat aac ggc cgc cac cac cga atg gac gag ttc tcc cgg gga aat      247
 Thr Asn Asn Gly Arg His His Arg Met Asp Glu Phe Ser Arg Gly Asn
      55                  60                  65

 gta ccg tcc agc gag ttg cag atc tac act tgg atg gat gca act ttg      295
 Val Pro Ser Ser Glu Leu Gln Ile Tyr Thr Trp Met Asp Ala Thr Leu
  70                  75                  80                  85

 aaa gaa ctg aca agc tta gta aaa gaa gtc tac cca gaa gct aga aag      343
 Lys Glu Leu Thr Ser Leu Val Lys Glu Val Tyr Pro Glu Ala Arg Lys
                  90                  95                 100

 aag ggc act cac ttc aat ttt gca atc gtt ttt aca gat gtt aaa aga      391
 Lys Gly Thr His Phe Asn Phe Ala Ile Val Phe Thr Asp Val Lys Arg
             105                 110                 115

 cct ggc tat cga gtt aag gag att ggc agc acc atg tct ggc aga aag      439
 Pro Gly Tyr Arg Val Lys Glu Ile Gly Ser Thr Met Ser Gly Arg Lys
         120                 125                 130

 ggg act gat gat tcc atg acc ctg cag tcg cag aag ttc cag ata gga      487
 Gly Thr Asp Asp Ser Met Thr Leu Gln Ser Gln Lys Phe Gln Ile Gly
     135                 140                 145

 gat tac ttg gac ata gca att acc cct cca aat cgg gca cca cct cct      535
 Asp Tyr Leu Asp Ile Ala Ile Thr Pro Pro Asn Arg Ala Pro Pro Pro
 150                 155                 160                 165

 tca ggg cgc atg aga cca tat taa attctattta ctatttgttg aatttatttt     589
 Ser Gly Arg Met Arg Pro Tyr 
                 170

 tccgtcagtt atgtaaaata aacatactct tcttcctccc ctgattaatg ccatnaagcc    649

 ttttaattct attttttttt taatgcatca tttatttagg agttagattt ggatgtgcta    709

 ttgtatgatt acgaatagtc tgtatgtttc aagcccttct gtaaaatatg aagaaaagtg    769

 ctcttagcat tctgtgtaaa actgtactgt taaatatatg tgtgtaatca aaaaaaaaaa    829

 a                                                                    830




      <210> 35
      <211> 1339
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (81)..(965)

      <400> 35
 gcgatccggt tccgctcccc acaacccgct ctgtggcggg gcttccggtc gggagggtcc     60

 gccagctctc gcgtcctttg    atg ggt cca gac acc ggt acg tcc ggg cgg     110
                          Met Gly Pro Asp Thr Gly Thr Ser Gly Arg
                            1               5                  10

 gtt ttt agt ctc cca agc gag agc gtc gca ttc acc cgc gtg ggt ctg      158
 Val Phe Ser Leu Pro Ser Glu Ser Val Ala Phe Thr Arg Val Gly Leu
                  15                  20                  25

 cgg gcg ccc cag acc cca gag gac ccg gcc ccc aac ggt tac ctg tcc      206
 Arg Ala Pro Gln Thr Pro Glu Asp Pro Ala Pro Asn Gly Tyr Leu Ser
              30                  35                  40

 cct ctc ctg tcc ctc ccc cat tcc agc ccc ttc tct ccc cag ccg ttg      254
 Pro Leu Leu Ser Leu Pro His Ser Ser Pro Phe Ser Pro Gln Pro Leu
          45                  50                  55

 ccc ctc ccc gca ccc cgc cgg gtc cgc gcg cct ctc tcc gcg cgc acc      302
 Pro Leu Pro Ala Pro Arg Arg Val Arg Ala Pro Leu Ser Ala Arg Thr
      60                  65                  70

 ccc aaa ccg ccc cct ttt ctc tgg gaa ccg ctc ctt ccg ctc cgc ccg      350
 Pro Lys Pro Pro Pro Phe Leu Trp Glu Pro Leu Leu Pro Leu Arg Pro
  75                  80                  85                  90

 cct gga gtc ttc tgg ccg gat tcc gcg gca tcc ttc cat aga ccc tcg      398
 Pro Gly Val Phe Trp Pro Asp Ser Ala Ala Ser Phe His Arg Pro Ser
                  95                 100                 105

 ttg ttg ctt cct cct tgt ggt tcc gtt gca aac att ttt aaa ggg ctg      446
 Leu Leu Leu Pro Pro Cys Gly Ser Val Ala Asn Ile Phe Lys Gly Leu
             110                 115                 120

 gtt att ctt cct gaa atg agt ttg gtg att aga aat ctg cag cga gtc      494
 Val Ile Leu Pro Glu Met Ser Leu Val Ile Arg Asn Leu Gln Arg Val
         125                 130                 135

 atc ccc atc agg aga gcg cca ctt cgc agt aag atc gag att gta agg      542
 Ile Pro Ile Arg Arg Ala Pro Leu Arg Ser Lys Ile Glu Ile Val Arg
     140                 145                 150

 agg att tta gga gtg cag aaa ttt gac ctg ggg atc atc tgt gtt gac      590
 Arg Ile Leu Gly Val Gln Lys Phe Asp Leu Gly Ile Ile Cys Val Asp
 155                 160                 165                 170

 aac aag aat att cag cac att aat aga atc tac aga gat aga aat gtc      638
 Asn Lys Asn Ile Gln His Ile Asn Arg Ile Tyr Arg Asp Arg Asn Val
                 175                 180                 185

 cca acc gat gtg ctt tct ttt cca ttt cat gag cat ctg aaa gca ggt      686
 Pro Thr Asp Val Leu Ser Phe Pro Phe His Glu His Leu Lys Ala Gly
             190                 195                 200

 gaa ttt ccc cag cct gat ttt cca gat gac tac aat ttg gga gac att      734
 Glu Phe Pro Gln Pro Asp Phe Pro Asp Asp Tyr Asn Leu Gly Asp Ile
         205                 210                 215

 ttc cta gga gtg gag tat atc ttc cat cag tgt aaa gaa aat gaa gat      782
 Phe Leu Gly Val Glu Tyr Ile Phe His Gln Cys Lys Glu Asn Glu Asp
     220                 225                 230

 tac aat gac gtc ctg act gtg acg gcc acc cac gga ctc tgt cac ttg      830
 Tyr Asn Asp Val Leu Thr Val Thr Ala Thr His Gly Leu Cys His Leu
 235                 240                 245                 250

 ctg gga ttc aca cac ggc acg gag gca gag tgg cag cag atg ttc cag      878
 Leu Gly Phe Thr His Gly Thr Glu Ala Glu Trp Gln Gln Met Phe Gln
                 255                 260                 265

 aag gag aag gcg gtg ctg gac gag ctg ggc cga cgc acg ggg acc cgg      926
 Lys Glu Lys Ala Val Leu Asp Glu Leu Gly Arg Arg Thr Gly Thr Arg
             270                 275                 280

 ctg cag ccc ctg acc cgg ggc ctc ttc gga ggg agc tga gggccgcgtt       975
 Leu Gln Pro Leu Thr Arg Gly Leu Phe Gly Gly Ser 
         285                 290

 ccttctgaaa gcgggacgac ggcgaggcgc agggaggcct gcaggcgggc gcccgggcgg   1035

 tcggcaaacc caactgaaaa gtacaggaaa tacccggtaa cataagaaaa gcaaaacaag   1095

 caaacgaaac aagagaaaga caaagaacaa caaacaaaga acagacaaaa gcgaaacaac   1155

 aacacacagc aaccaacaca caaaaaacaa aacacgcaaa cgcactgggc ggcaagacga   1215

 gagacacaac agagggcaaa accgaagcga ccgcacacga cagcaaagaa gagacgaagg   1275

 gacaaagaac acaacgcccg gcagacaacc cacgacggga gacgagaagc aacgaaacgg   1335

 aacg                                                                1339




      <210> 36
      <211> 1328
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (81)..(827)

      <400> 36
 gcgatccggt tccgctcccc acaacccgct ctgtggcggg gcttccggtc gggagggtcc     60

 gccagctctc gcgtcctttg    atg ggt cca gac acc ggt acg tcc ggg cgg     110
                          Met Gly Pro Asp Thr Gly Thr Ser Gly Arg
                            1               5                  10

 gtt ttt agt ctc cca agc gag agc gtc gca ttc acc cgc gtg ggt ctg      158
 Val Phe Ser Leu Pro Ser Glu Ser Val Ala Phe Thr Arg Val Gly Leu
                  15                  20                  25

 cgg gcg ccc cag acc cca gag gac ccg gcc ccc aac ggt tac ctg tcc      206
 Arg Ala Pro Gln Thr Pro Glu Asp Pro Ala Pro Asn Gly Tyr Leu Ser
              30                  35                  40

 cct ctc ctg tcc ctc ccc cat tcc agc ccc ttc tct ccc cag ccg ttg      254
 Pro Leu Leu Ser Leu Pro His Ser Ser Pro Phe Ser Pro Gln Pro Leu
          45                  50                  55

 ccc ctc ccc gca ccc cgc cgg gtc cgc gcg cct ctc tcc gcg cgc acc      302
 Pro Leu Pro Ala Pro Arg Arg Val Arg Ala Pro Leu Ser Ala Arg Thr
      60                  65                  70

 ccc aaa ccg ccc cct ttt ctc tgg gaa ccg ctc ctt ccg ctc cgc ccg      350
 Pro Lys Pro Pro Pro Phe Leu Trp Glu Pro Leu Leu Pro Leu Arg Pro
  75                  80                  85                  90

 cct gga gtc ttc tgg ccg gat tcc gcg gca tcc ttc cat aga ccc tcg      398
 Pro Gly Val Phe Trp Pro Asp Ser Ala Ala Ser Phe His Arg Pro Ser
                  95                 100                 105

 ttg ttg ctt cct cct tgt ggt tcc gtt gca aac att ttt aaa ggg ctg      446
 Leu Leu Leu Pro Pro Cys Gly Ser Val Ala Asn Ile Phe Lys Gly Leu
             110                 115                 120

 gtt att ctt cct gaa atg agt ttg gtg att aga aat ctg cag cga gtc      494
 Val Ile Leu Pro Glu Met Ser Leu Val Ile Arg Asn Leu Gln Arg Val
         125                 130                 135

 atc ccc atc agg aga gcg cca ctt cgc agt aag atc gag att gta agg      542
 Ile Pro Ile Arg Arg Ala Pro Leu Arg Ser Lys Ile Glu Ile Val Arg
     140                 145                 150

 agg att tta gga gtg cag aaa ttt gac ctg ggg atc atc tgt gtt gac      590
 Arg Ile Leu Gly Val Gln Lys Phe Asp Leu Gly Ile Ile Cys Val Asp
 155                 160                 165                 170

 aac aag aat att cag cac att aat aga atc tac aga gat aga aat gtc      638
 Asn Lys Asn Ile Gln His Ile Asn Arg Ile Tyr Arg Asp Arg Asn Val
                 175                 180                 185

 cca acc gat gtg ctt tct ttt cca ttt cat gag cat ctg aaa gca ggt      686
 Pro Thr Asp Val Leu Ser Phe Pro Phe His Glu His Leu Lys Ala Gly
             190                 195                 200

 gaa ttt ccc cag cct gat ttt cca gat gac tac aat ttg gga gac att      734
 Glu Phe Pro Gln Pro Asp Phe Pro Asp Asp Tyr Asn Leu Gly Asp Ile
         205                 210                 215

 ttc cta gga gtg gag tat atc ttc cat cag tgt aaa gaa aat gaa gat      782
 Phe Leu Gly Val Glu Tyr Ile Phe His Gln Cys Lys Glu Asn Glu Asp
     220                 225                 230

 tac aat gac gtc ctg act gta agc ggg gat gct gaa atc ata taa cct      830
 Tyr Asn Asp Val Leu Thr Val Ser Gly Asp Ala Glu Ile Ile 
 235                 240                 245

 ggctcatgga acatgggcct tgcaaagggg tcaagatcac aaccctgcat ccatgtgtgt    890

 ccgtgggtac cgtaagggct actgggggaa gaacctgtaa gcagggtgtg aggagcaccc    950

 aggctggtag ggactgcatg ccccatgcca cagttgaagg agggagagaa cacgctgtga   1010

 aaacacagaa gctcccagag aagccttctc agcttttatc tctggagtag agcagactat   1070

 gttgagctaa cacagacctg tgaatcagtt ctttctgagc tgccagaagt acagaagttg   1130

 gagccctcac acttccagat ctgtttctcc tcaatgtaat cacctatggg ttcttcctgg   1190

 ccactggaag acaaaacatt cactgcatgt gggtgcgaaa aaagattaca gagtgcagaa   1250

 aaaaaaaaac cgaggttttg ggcgggaaag ggagggcgca gttcgccctt gtaaggaatg   1310

 cgcccaaggc gaacaagc                                                 1328




      <210> 37
      <211> 2346
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (193)..(1119)

      <400> 37
 tccggaattc ccgggtcgac gtttcgtggg aaaggggcag catgatggtc tgagatggtg     60

 tagcgtcgga ccatgtggaa gtttctgagg ctggggagcc ggataatggg gggtggggcc    120

 cgttgggggg taaaggggca atagcgtcct ttcacaggct aacctcggct cttcccagtc    180

 ctctggacta aa    atg ggg aac aca ttg ggc ctg gca cca atg ggg act     228
                  Met Gly Asn Thr Leu Gly Leu Ala Pro Met Gly Thr
                    1               5                  10

 ttg ccc cgc cgg agc ccc cgc cga gag gaa ccc ctg ccc aac cct ggg      276
 Leu Pro Arg Arg Ser Pro Arg Arg Glu Glu Pro Leu Pro Asn Pro Gly
          15                  20                  25

 agc ttc gat gag ctg cac cgt cta tgc aaa gat gta ttc cca gca cag      324
 Ser Phe Asp Glu Leu His Arg Leu Cys Lys Asp Val Phe Pro Ala Gln
      30                  35                  40

 atg gag gga gtg aag ctc gtt gtc aac aag gtt ctg agc agc cat ttc      372
 Met Glu Gly Val Lys Leu Val Val Asn Lys Val Leu Ser Ser His Phe
  45                  50                  55                  60

 cag gtg gcg cac act ata cac atg agt gcc ctg ggc ttg ccg gga tat      420
 Gln Val Ala His Thr Ile His Met Ser Ala Leu Gly Leu Pro Gly Tyr
                  65                  70                  75

 cac ctc cat gcg gcc tat gca ggg gat tgg cag ctc agt ccc act gag      468
 His Leu His Ala Ala Tyr Ala Gly Asp Trp Gln Leu Ser Pro Thr Glu
              80                  85                  90

 gtg ttc ccc act gtg gta ggg gat atg gac agc agt ggc agc ctg aac      516
 Val Phe Pro Thr Val Val Gly Asp Met Asp Ser Ser Gly Ser Leu Asn
          95                 100                 105

 gcc cag gtc ttg ctc ctc ttg gca gag cgg ctc cga gct aag gct gtc      564
 Ala Gln Val Leu Leu Leu Leu Ala Glu Arg Leu Arg Ala Lys Ala Val
     110                 115                 120

 ttc cag acg cag cag gcc aag ttc ctg aca tgg cag ttt gat ggc gag      612
 Phe Gln Thr Gln Gln Ala Lys Phe Leu Thr Trp Gln Phe Asp Gly Glu
 125                 130                 135                 140

 tat cgg gga gat gac tac aca gcc act ctg acc cta gga aat cct gac      660
 Tyr Arg Gly Asp Asp Tyr Thr Ala Thr Leu Thr Leu Gly Asn Pro Asp
                 145                 150                 155

 ctg att ggg gag tcg gtg atc atg gtt gct cac ttc ctg cag agc ctc      708
 Leu Ile Gly Glu Ser Val Ile Met Val Ala His Phe Leu Gln Ser Leu
             160                 165                 170

 act cat cgg ctg gtg ctg gga gga gag cta gtt tat cac cgg cgg cca      756
 Thr His Arg Leu Val Leu Gly Gly Glu Leu Val Tyr His Arg Arg Pro
         175                 180                 185

 ggc gaa gag ggg gcc atc ttg aca ctg gct ggg aag tac tcg gct gta      804
 Gly Glu Glu Gly Ala Ile Leu Thr Leu Ala Gly Lys Tyr Ser Ala Val
     190                 195                 200

 cac tgg gta gct aca ttg aat gtg gga tca ggc ggg gcc cat gca agt      852
 His Trp Val Ala Thr Leu Asn Val Gly Ser Gly Gly Ala His Ala Ser
 205                 210                 215                 220

 tac tac cac agg gca aat gaa cag gtt cag gtt gga gtg gag ttt gag      900
 Tyr Tyr His Arg Ala Asn Glu Gln Val Gln Val Gly Val Glu Phe Glu
                 225                 230                 235

 gca aac aca agg cta caa gac aca aca ttc tcc ttt ggt tac cac ctg      948
 Ala Asn Thr Arg Leu Gln Asp Thr Thr Phe Ser Phe Gly Tyr His Leu
             240                 245                 250

 act ctg ccc cag gcc aac atg gta ttt aga ggc ttg gtg gat agt aac      996
 Thr Leu Pro Gln Ala Asn Met Val Phe Arg Gly Leu Val Asp Ser Asn
         255                 260                 265

 tgg tgt gta ggt gct gtg ctg gag aag aag atg ccc cct ctg cct gtc     1044
 Trp Cys Val Gly Ala Val Leu Glu Lys Lys Met Pro Pro Leu Pro Val
     270                 275                 280

 acc cta gcc ctt gga gcc ttc ctc aat cac tgg cgc aac aga ttc cat     1092
 Thr Leu Ala Leu Gly Ala Phe Leu Asn His Trp Arg Asn Arg Phe His
 285                 290                 295                 300

 tgt ggc ttc agc atc act gtg ggc tga ggttg tccagagcca gcccccacag     1144
 Cys Gly Phe Ser Ile Thr Val Gly 
                 305

 cagctggaac ctctgagtca ggtgccctag ggccaaagac taggcccctc ttcagagccc   1204

 accttgctgg gtgatctcta ggacccagga gcagagtggt ggacaggacc atgccctcct   1264

 cagaactgga gctgccacag gggcagttga tgaggcagag gtttgaggat cccccctctg   1324

 ctaccagccc cagtatcacc ttccccatgc tcttgtggct gtggactaag ggagaaggat   1384

 taaggggtat ggctgaattc ccccggcacc ccttgccctc aggcttcctt cttcctttcc   1444

 ctttggttaa tcctgcatgg gattagctga ccatcctgtt ttccatccca gagcctccca   1504

 aggctgggaa agtagggctg aagggctaga tgtttggtct caggaagtgg ggcccaccca   1564

 ttcccagaag gagcttcttt acctcttagc cctgaggttt cctccttccc atcttctgtg   1624

 cttccagaga acaactttgt tcctatggtc acccccacta tccccatgac cgcatgaaga   1684

 ggcagttatt gctttagtct ttcattgcaa ccactgggct ccctttgaac ccggcccaat   1744

 ctttggtccc agcattttcc cactccagtg tatccagggt gttccaggtg agcgatcccg   1804

 gggccttcgc tgctggccct tgatgtagct ttgcagagtc agtgccatct cctcttgcag   1864

 ctgatcaatc tcatctctct gggtaactcc aggtcggtca ggagagaaga gagccatgca   1924

 ggccaagagc gcatactcag gctcttggag cttgcaattt tccgtaggtt ccatgcaatt   1984

 gaaaagcact tcgaaaactc ttactgggaa cccaaaacgg ctccaacttc aattgggtag   2044

 ccaaaaggcc ccccaaagaa atttttttat ttggaaccag aaagtagtaa ttgagtagcg   2104

 atttaacaga tttccacaga ttgtcccctt gaaaaaaggg aattttagtc ctcaaatggg   2164

 gaggagaacc gaaaacgggt acagtccctt ggaagaactt gagggcttgt gaaaaccacg   2224

 gagaagttta aaagttccaa aatttttgcc cagacgagaa caagtggcac gatagaaaaa   2284

 gagattagag aggtaagaca agagacgcga gagtcaaaaa tgacgaagat ttagaaaagg   2344

 ag                                                                  2346




      <210> 38
      <211> 971
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(924)

      <400> 38
 tttcgtgggc ccggggccga gacg   atg gct gac cac aac cct gac agc gac      51
                              Met Ala Asp His Asn Pro Asp Ser Asp
                                1               5

 tcc acg ccg cgc acg ctg ctg cga cgc gtg ctg gat aca gcg gac ccg       99
 Ser Thr Pro Arg Thr Leu Leu Arg Arg Val Leu Asp Thr Ala Asp Pro
  10                  15                  20                  25

 cgc acc ccg cgg cga ccc cgg agt gct cgg gct gga gcc cgg aga gcc      147
 Arg Thr Pro Arg Arg Pro Arg Ser Ala Arg Ala Gly Ala Arg Arg Ala
                  30                  35                  40

 ctg ctt gaa acg gct tcc ccc agg aag ttg agt ggc caa aca agg acg      195
 Leu Leu Glu Thr Ala Ser Pro Arg Lys Leu Ser Gly Gln Thr Arg Thr
              45                  50                  55

 ata gcc aga ggg cgt tcc cat gga gcc agg tct gtt ggc aga tcg gcc      243
 Ile Ala Arg Gly Arg Ser His Gly Ala Arg Ser Val Gly Arg Ser Ala
          60                  65                  70

 cat att cag gcc agt ggg cac ttg gag gaa cag aca cct cgg acg ctg      291
 His Ile Gln Ala Ser Gly His Leu Glu Glu Gln Thr Pro Arg Thr Leu
      75                  80                  85

 ctg aag aac atc cta cta act gcc cca gaa tct tcc atc ctg atg cct      339
 Leu Lys Asn Ile Leu Leu Thr Ala Pro Glu Ser Ser Ile Leu Met Pro
  90                  95                 100                 105

 gag tcg gta gtg aag cca gtg cca gca ccg cag gcg gtc caa ccc tcc      387
 Glu Ser Val Val Lys Pro Val Pro Ala Pro Gln Ala Val Gln Pro Ser
                 110                 115                 120

 aga caa gag agc agt tgc ggc agc ctg gag ctg caa ctt cct gag ctc      435
 Arg Gln Glu Ser Ser Cys Gly Ser Leu Glu Leu Gln Leu Pro Glu Leu
             125                 130                 135

 gag ccc ccc aca acc ctg gct cca ggt ctg ctg gcc cct ggc agg agg      483
 Glu Pro Pro Thr Thr Leu Ala Pro Gly Leu Leu Ala Pro Gly Arg Arg
         140                 145                 150

 aaa cag agg ctg aga ctg tca gtg ttt cag cag gga gtg gac cag ggg      531
 Lys Gln Arg Leu Arg Leu Ser Val Phe Gln Gln Gly Val Asp Gln Gly
     155                 160                 165

 ctg tct ctc tcc caa gag cct caa ggg aat gct gat gcc tct tcc ctc      579
 Leu Ser Leu Ser Gln Glu Pro Gln Gly Asn Ala Asp Ala Ser Ser Leu
 170                 175                 180                 185

 acc aga tcc ctc aac ctg acc ttt gcc aca cct ctt cag cca cag tca      627
 Thr Arg Ser Leu Asn Leu Thr Phe Ala Thr Pro Leu Gln Pro Gln Ser
                 190                 195                 200

 gtg cag agg cct ggc ttg gcc cgc aga cct cca gcc cgc cga gct gta      675
 Val Gln Arg Pro Gly Leu Ala Arg Arg Pro Pro Ala Arg Arg Ala Val
             205                 210                 215

 gac gtg ggt gcc ttt ttg cgg gat ctg cga gat act tcc ctg gct cct      723
 Asp Val Gly Ala Phe Leu Arg Asp Leu Arg Asp Thr Ser Leu Ala Pro
         220                 225                 230

 cca aac att gtg ttg gag gac acc cag ccg ttc tct cag ccc atg gtt      771
 Pro Asn Ile Val Leu Glu Asp Thr Gln Pro Phe Ser Gln Pro Met Val
     235                 240                 245

 ggc tcc ccc aac gtg tat cac tcc ctg ccc tgc acg cct cac act ggg      819
 Gly Ser Pro Asn Val Tyr His Ser Leu Pro Cys Thr Pro His Thr Gly
 250                 255                 260                 265

 gct gaa gac gct gag cag gct gcc ggt cgc aag aca cag agc agt ggg      867
 Ala Glu Asp Ala Glu Gln Ala Ala Gly Arg Lys Thr Gln Ser Ser Gly
                 270                 275                 280

 cct ggg ctg cag aag aat agt gag tgt gtg gca ctg gtg gcc tgg agc      915
 Pro Gly Leu Gln Lys Asn Ser Glu Cys Val Ala Leu Val Ala Trp Ser
             285                 290                 295

 caa att tag cttgggt gagagttgac aatggtagtt ttccttcctc aagcccctct      971
 Gln Ile 






      <210> 39
      <211> 1930
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (53)..(847)

      <400> 39
 ttcccgggtc gacgatttcg ttttgctgga gggcctggag gtggaccagt ac    atg      55
                                                              Met
                                                                1

 ctg ggc atc ctg att tac att cag aac tct gac tat gag gag atc acc      103
 Leu Gly Ile Leu Ile Tyr Ile Gln Asn Ser Asp Tyr Glu Glu Ile Thr
               5                  10                  15

 atc gac ccc acg tgc agc tgg aag cca gtg ccc gtg aag cct gac atg      151
 Ile Asp Pro Thr Cys Ser Trp Lys Pro Val Pro Val Lys Pro Asp Met
          20                  25                  30

 cac atc aag gag gag ccg gat ggg cca gca ctg aag cgc tgc cgc acc      199
 His Ile Lys Glu Glu Pro Asp Gly Pro Ala Leu Lys Arg Cys Arg Thr
      35                  40                  45

 gtg agc ccc gcc cac gtg ctc atg ccc agc gtg atg gag atg atc gcc      247
 Val Ser Pro Ala His Val Leu Met Pro Ser Val Met Glu Met Ile Ala
  50                  55                  60                  65

 gcc ctg ggc ccc ggc gct gcc ccc ttt gcc ccc ctg cag ccc ccc tca      295
 Ala Leu Gly Pro Gly Ala Ala Pro Phe Ala Pro Leu Gln Pro Pro Ser
                  70                  75                  80

 gtc cct gcc ccc agc gac tac cct ggc cag ggt tcc agc ttc ctg ggg      343
 Val Pro Ala Pro Ser Asp Tyr Pro Gly Gln Gly Ser Ser Phe Leu Gly
              85                  90                  95

 cct gga act ttc cct gag tcc ttc cca ccc acc acg ccc agc acc cca      391
 Pro Gly Thr Phe Pro Glu Ser Phe Pro Pro Thr Thr Pro Ser Thr Pro
         100                 105                 110

 acc ctt gct gag ttc acc ccg gga cca ccc ccc atc tcc tac cag tct      439
 Thr Leu Ala Glu Phe Thr Pro Gly Pro Pro Pro Ile Ser Tyr Gln Ser
     115                 120                 125

 gac att ccc agc agc ctc ctg act tca gag aag tct acc gcc tgc ctc      487
 Asp Ile Pro Ser Ser Leu Leu Thr Ser Glu Lys Ser Thr Ala Cys Leu
 130                 135                 140                 145

 cca agc cag atg gca cca gca ggt cac ctg gac ccc act cac aat cct      535
 Pro Ser Gln Met Ala Pro Ala Gly His Leu Asp Pro Thr His Asn Pro
                 150                 155                 160

 ggg aca cca gga cta cac acc tcc aac ctt ggg gcc cct cca ggt ccc      583
 Gly Thr Pro Gly Leu His Thr Ser Asn Leu Gly Ala Pro Pro Gly Pro
             165                 170                 175

 cag ctg cac cat tca aac cct ccc cca gcg tcc cgg cag tcc ttg ggc      631
 Gln Leu His His Ser Asn Pro Pro Pro Ala Ser Arg Gln Ser Leu Gly
         180                 185                 190

 caa gcg agc tta gga cct acg ggt gaa ctg gcc ttc agt cct gcc aca      679
 Gln Ala Ser Leu Gly Pro Thr Gly Glu Leu Ala Phe Ser Pro Ala Thr
     195                 200                 205

 ggc gtg atg ggg ccc ccc agc atg tct gga gcc ggg gag gcc cca gaa      727
 Gly Val Met Gly Pro Pro Ser Met Ser Gly Ala Gly Glu Ala Pro Glu
 210                 215                 220                 225

 cca gct ctg gac ctg ctc ccg gaa ctg acc aac cct gat gag cta ctg      775
 Pro Ala Leu Asp Leu Leu Pro Glu Leu Thr Asn Pro Asp Glu Leu Leu
                 230                 235                 240

 tcc tac ttg ggc cca ccc gac ctc cct acg aac aac aat gac gac ctg      823
 Ser Tyr Leu Gly Pro Pro Asp Leu Pro Thr Asn Asn Asn Asp Asp Leu
             245                 250                 255

 ctt tct ctg ttt gag aac aac tga tcctgtgttt accccaagcc cggcggggac     877
 Leu Ser Leu Phe Glu Asn Asn 
         260

 acgctcacag atgtcaccac agccctgccc ttcatgccca gccccatggg acacccggtg    937

 gtctttccca aacctccccc aaaacacacc tggagccaga gccttctgcc gccagccctg    997

 cccctgaatt ggaagcagcc ctgtgctcga tgggaggggc tcccaggccg gcagcccttg   1057

 ccacctccct ctgccaagcc tgctgctgca gaacggtttt tgctgaggtg cccctgccca   1117

 gccctgtcca gccttgtcca cacacacatc tcacgcccct ggtctcacag cctcacacct   1177

 tgtccttcca cccctgcctg cccccaccca gcctgcttct tgtccagcat tgatccttct   1237

 gtttcaacaa ctcctccact gggcagagct gggcatctgg cagggctggc tctgtcccct   1297

 gggcctttgg ctccagtggc ccctgtgccc agcagtccag ctcttggaac ctcgctgaat   1357

 ggcagcctct tgggggcctg gagctctggc agcccagccg tgtgtggtgt caggttcctc   1417

 tccccacccc agcttcaagc agaggcctcg gggtggggga gctacaaagc acaacaatgt   1477

 acatagtgta gaaacactaa cagctgggag aggggagcca gctgtccagc cagcatgttc   1537

 ctgttgtaca gcccggtctc cctgcgcgct ctgctccttc ccatgtgcag acagatcagg   1597

 gaggaacctc caatgggtgg gggacagtga gcttcggcct ggccgaggtg ggtgggtggg   1657

 ctctcagatt cagctctgtg taaagattct ctagcgggct gcgctcccaa gttccccttc   1717

 tctgtgaaag tgaagaatta gtacagctgt gttttttaaa gccacctctc tgtctccacc   1777

 ccatgggccc acacccaggt gggggaggag gaagccactg catctgttgg ctcagggccc   1837

 cagcctgtgc aagcagggcg cctgggctgt tgtgtctcct gtctgtgccg atctctatta   1897

 aaggactccc tcttggtggg caaaaaaaaa aaa                                1930




      <210> 40
      <211> 855
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (149)..(619)

      <400> 40
 ggcagagatg gtgaaaacat cagggagcag gtggtggctg ttccagtttc ttatctcagg     60

 agggaagagc tgcagatgtc tttactgtga atgagggaga gaaacgctaa agcacagaaa    120

 tgttcagaac caaagagctg gatcactc   atg ctt cta gaa aag aca ttg gca     172
                                  Met Leu Leu Glu Lys Thr Leu Ala
                                    1               5

 tct tct cat tgc tca tct act gtg cct ggc aca gcc tta ttt tct agc      220
 Ser Ser His Cys Ser Ser Thr Val Pro Gly Thr Ala Leu Phe Ser Ser
      10                  15                  20

 ttt ctg aat gtg agt tcc atc cat atc ctt tgc ata acg gtg gta ctg      268
 Phe Leu Asn Val Ser Ser Ile His Ile Leu Cys Ile Thr Val Val Leu
  25                  30                  35                  40

 ggc tgt gga gag ctt gga atg tgt gtc cat ggg gaa atg ggc tgt tct      316
 Gly Cys Gly Glu Leu Gly Met Cys Val His Gly Glu Met Gly Cys Ser
                  45                  50                  55

 ggt tat tat aaa acg gcc aag gga ggg ctc cat ggc aca cct ctg agt      364
 Gly Tyr Tyr Lys Thr Ala Lys Gly Gly Leu His Gly Thr Pro Leu Ser
              60                  65                  70

 aac cca gga cac tcc tgt ttg gga aat gca aac cat cca tac ggc agg      412
 Asn Pro Gly His Ser Cys Leu Gly Asn Ala Asn His Pro Tyr Gly Arg
          75                  80                  85

 ggc aca att ata aag att gat cct gtc acg gga atg gtt tca aat ctg      460
 Gly Thr Ile Ile Lys Ile Asp Pro Val Thr Gly Met Val Ser Asn Leu
      90                  95                 100

 acc aac ctc atg gca tac att ggg gaa gca att gtg aaa ccc ctt gat      508
 Thr Asn Leu Met Ala Tyr Ile Gly Glu Ala Ile Val Lys Pro Leu Asp
 105                 110                 115                 120

 tct ttg gat ctg gac atg ctg tac tgt gac aat ggt ttg tgt gtg aca      556
 Ser Leu Asp Leu Asp Met Leu Tyr Cys Asp Asn Gly Leu Cys Val Thr
                 125                 130                 135

 gaa aat gta gct gtg tct acc ggg aaa gac tgg gga aat ttc ttc ctg      604
 Glu Asn Val Ala Val Ser Thr Gly Lys Asp Trp Gly Asn Phe Phe Leu
             140                 145                 150

 tgg agt tct tta taa agcaaaagtg catgaaactg tcagtaatat tgtagtctat      659
 Trp Ser Ser Leu 
         155

 aaagggaaat tgctcttaga ggctaatatt gcacaatgac tacttttttt gcttatttgg    719

 aaaagatctt tatctcttgg agtattaaga agtcaacata taattgccac cctatacatt    779

 gtgttctgga gtgcctgatt tattgaaatc agtgtgaaac ctattttaaa taaatatcta    839

 tttcaaaaaa aaaaaa                                                    855




      <210> 41
      <211> 1225
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (563)..(1174)

      <400> 41
 ggcggcgggt gggagagttc tacgagggag gggaagcggt tggacgtgtt cgcttgggtt     60

 cctgctgcgg cagccacctc gcaatctctc tgcatcgatc gccgctcgca agctactgac    120

 cgtactcggg cgtattagga gccgcgttcc agcctcacac cccacggtgc tgttttcgac    180

 ttcagaaagg atctagtctc agcacagaag cgcctcaggc gcggcgcaaa gctcgagcgg    240

 acggcggggg cggccggagc ctctctcggg ggagccgcgc ctgaggaggc ggaagaaccc    300

 ccctgacgcg actggcgtgt gcttctgccc gccaccgccc ctcccgctct cacccgggcc    360

 gtccctggcc actgcccctg ccgcggaggc agcggcggca gcggctctcc tttccacagc    420

 cggcgctccg cgacccgctt ggctcctgag cccgtcgggt aggctctcct cgagttcccg    480

 ctcttcaccc cttccctcac cctcttcttt cgtcacccgt ccccgacccc acccgagccc    540

 ggcgcctcag ctgcccccgg cc atg gcg tgc gga gcc act ctg aaa agg act     592
                          Met Ala Cys Gly Ala Thr Leu Lys Arg Thr
                            1               5                  10

 ctg gat ttc gac ccg ctg ttg agc ccg gcg tcc ccg aag cgc agg cga      640
 Leu Asp Phe Asp Pro Leu Leu Ser Pro Ala Ser Pro Lys Arg Arg Arg
                  15                  20                  25

 tgt gcg cca ttg tcg gcg ccc acc tcg gcc gct gcc tcc ccg ttg tcg      688
 Cys Ala Pro Leu Ser Ala Pro Thr Ser Ala Ala Ala Ser Pro Leu Ser
              30                  35                  40

 gcg gcc gcg gcc acc gcc gcc tcc ttc tcc gct gcg gcc gcc tcg ccg      736
 Ala Ala Ala Ala Thr Ala Ala Ser Phe Ser Ala Ala Ala Ala Ser Pro
          45                  50                  55

 cag aag tat ctc cga atg gag cca tcc ccc ttc ggc gac gtc tcc tcc      784
 Gln Lys Tyr Leu Arg Met Glu Pro Ser Pro Phe Gly Asp Val Ser Ser
      60                  65                  70

 cgc ctc acc aca gaa caa att ctg tac aac ata aaa caa gag tat aaa      832
 Arg Leu Thr Thr Glu Gln Ile Leu Tyr Asn Ile Lys Gln Glu Tyr Lys
  75                  80                  85                  90

 cga atg cag aag aga aga cat tta gaa acg agt ttc caa cag aca gat      880
 Arg Met Gln Lys Arg Arg His Leu Glu Thr Ser Phe Gln Gln Thr Asp
                  95                 100                 105

 ccg tgt tgt act tct gat gca cag cca cat gca ttt ctc ctc agt gga      928
 Pro Cys Cys Thr Ser Asp Ala Gln Pro His Ala Phe Leu Leu Ser Gly
             110                 115                 120

 cca gct tca cca ggg act tca tct gca gca tcc tca cca tta aaa aaa      976
 Pro Ala Ser Pro Gly Thr Ser Ser Ala Ala Ser Ser Pro Leu Lys Lys
         125                 130                 135

 gaa cag ccc tta ttt act cta cgg cag gtt ggg atg atc tgt gaa cgt     1024
 Glu Gln Pro Leu Phe Thr Leu Arg Gln Val Gly Met Ile Cys Glu Arg
     140                 145                 150

 ttg ttg aaa gaa cgt gaa gag aaa gtt cga gaa gaa tat gaa gaa ata     1072
 Leu Leu Lys Glu Arg Glu Glu Lys Val Arg Glu Glu Tyr Glu Glu Ile
 155                 160                 165                 170

 ttg aac aca aaa ctt gca gaa caa tat gat gcg ttt gtg aag ttt acg     1120
 Leu Asn Thr Lys Leu Ala Glu Gln Tyr Asp Ala Phe Val Lys Phe Thr
                 175                 180                 185

 cat gat caa ata atg cga cga tat gga gaa cag cct gct agc tat gtt     1168
 His Asp Gln Ile Met Arg Arg Tyr Gly Glu Gln Pro Ala Ser Tyr Val
             190                 195                 200

 tca tga atcacgtatc ctgcatttgt gggctgcctt gttccttgtt gagttgttgc      1224
 Ser 


 a                                                                   1225




      <210> 42
      <211> 1066
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (599)..(934)

      <400> 42
 ggccgggact tgaggtggtc tcctagcagg aggagcgaga gagcccagca gcgatacggt     60

 ggttttcgac ccagctaggg gccaggccgt acgattggga gcccggggca gccccccgcg    120

 cagtcaccac gacgcggcac ccgtggacgg gcgttggctc tgcgtggtgg gcggctggga    180

 cgggtctcgc cgcttggcca cagtgaccgc actggacaca gagcgcggtg tgtgggaggc    240

 gtggacaggg acccctggtg actgcccccc cgccggcctc agtagtcaca cctgcacccg    300

 aatctctgac cgagagctgc aggtggctgg ccgggagggc ggtatccaca ctcagcgacg    360

 ctatggaagc atctacacat taaggctgga ccccagcgcc cgcacctatt gctacaagca    420

 agaaggctgc cacacagcct cacgctcagg tcactgtgcg gccctgctcc aaactcctgg    480

 accccatcca ggtcatcagc tattgctctt tggaggttgc aacttagctg aaccagaagt    540

 agctgggcat tggagtcatg ggaaaattaa ggaggaacca cctgttgctc ctcatttg      598                                                                 
 atg gaa cag ctt gca agg ctt gtg agc agt ggg cag ggg tcc cag aag      646
 Met Glu Gln Leu Ala Arg Leu Val Ser Ser Gly Gln Gly Ser Gln Lys
   1               5                  10                  15

 ggg ccc cat gga cta cgg cat cac tca tgt tct gtg gtc ggg ccc ttt      694
 Gly Pro His Gly Leu Arg His His Ser Cys Ser Val Val Gly Pro Phe
              20                  25                  30

 gct gtg ctg ttt ggt gga gaa act ctg acc aga gct aga gac acc atc      742
 Ala Val Leu Phe Gly Gly Glu Thr Leu Thr Arg Ala Arg Asp Thr Ile
          35                  40                  45

 tgc aat gat ctc tac atc tat gat act cgc aca tct cct cct ttg tgg      790
 Cys Asn Asp Leu Tyr Ile Tyr Asp Thr Arg Thr Ser Pro Pro Leu Trp
      50                  55                  60

 ttc cac ttc ccc tgt gca gat cgt ggg atg aaa cgc atg ggc cat cgc      838
 Phe His Phe Pro Cys Ala Asp Arg Gly Met Lys Arg Met Gly His Arg
  65                  70                  75                  80

 acc tgc ctt tgg aat gat cag ctt tac ctg gtt ggg ggt ttt ggt gag      886
 Thr Cys Leu Trp Asn Asp Gln Leu Tyr Leu Val Gly Gly Phe Gly Glu
                  85                  90                  95

 gat ggc agg aca gcc agt cca cag gtt tgc atc ctg gac ttt atc taa      934
 Asp Gly Arg Thr Ala Ser Pro Gln Val Cys Ile Leu Asp Phe Ile 
             100                 105                 110

 atagtgccaa gacacatcac taagcctcgt tttgttttgc tttgttgcaa acctataaag    994

 cgttatcacc agagctatct gcttcacttc aaatgcttat taaatttcaa tctgagactc   1054

 aaaaaaaaaa aa                                                       1066




      <210> 43
      <211> 436
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(403)

      <400> 43
 acgggaccat agcacgttcc tgtctgcata ggccataagt cacgctgtct ctgagagtgg     60

 a    atg tca cca tcg gcc atg ggg gga ttt ttg tgt gta cag ttc act     106
      Met Ser Pro Ser Ala Met Gly Gly Phe Leu Cys Val Gln Phe Thr
        1               5                  10                  15

 gct gta cac cca gac ccc aga aca gag cct gtc cag gac aag tgc cca      154
 Ala Val His Pro Asp Pro Arg Thr Glu Pro Val Gln Asp Lys Cys Pro
                  20                  25                  30

 gta aac act tgg gaa gca atg caa gcg tcc tcc cag cag ctc ctg caa      202
 Val Asn Thr Trp Glu Ala Met Gln Ala Ser Ser Gln Gln Leu Leu Gln
              35                  40                  45

 aca gac ccc cga ccc aag ccc ttc ctt ctg cct cca ctg cca cca ctg      250
 Thr Asp Pro Arg Pro Lys Pro Phe Leu Leu Pro Pro Leu Pro Pro Leu
          50                  55                  60

 ctg ctc atc tct gct ggc aca gaa gtc tct tcc ctg gtc ttc cag aaa      298
 Leu Leu Ile Ser Ala Gly Thr Glu Val Ser Ser Leu Val Phe Gln Lys
      65                  70                  75

 tcc cct ctc cac act cag cca gag gga gct att aaa act gcg ggc cag      346
 Ser Pro Leu His Thr Gln Pro Glu Gly Ala Ile Lys Thr Ala Gly Gln
  80                  85                  90                  95

 ccc aca tca gtc cac agc aaa gtc ctc tct aag gga tct ttg ttg ctt      394
 Pro Thr Ser Val His Ser Lys Val Leu Ser Lys Gly Ser Leu Leu Leu
                 100                 105                 110

 gga gaa taa accctcggat tccttccttg aaaaaaaaaa aaa                     436
 Gly Glu 






      <210> 44
      <211> 725
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (355)..(648)

      <400> 44
 ctctgcctcc cagggtgctg ggattttagg cgtgattcac cgcgccggga cccaaggccg     60

 ggtaagtttt aaggcctcat tcttcagtca ggttttccct gttcccgcgt gttcggccaa    120

 tttttttttg ttgttgtttt gtttttgttt ttgtttttga gtcaattttc cagacatctt    180

 taattagcaa tatgtttaag tagttacaag cctttccttc ttttcttgtg acagtttggg    240

 ttgaatttct atcgtttgca gcctgtcact gtaaggcaca aacatgatca cgcaagatgc    300

 gatagtagat ttaagccagt tgtttttaag tttgtgttta aggagaaact aaca  atg     357
                                                              Met
                                                                1

 aaa acg gcc tcg ttg acg gag gaa aag ttg gaa tgc agc ctc tgg tgc      405
 Lys Thr Ala Ser Leu Thr Glu Glu Lys Leu Glu Cys Ser Leu Trp Cys
               5                  10                  15

 tgt ttg agc gat ccc tct ccc cgg ggc ctg gcc gcg cgc tgc tgt gtt      453
 Cys Leu Ser Asp Pro Ser Pro Arg Gly Leu Ala Ala Arg Cys Cys Val
          20                  25                  30

 ctg gaa ggg ctc att gta cag tca agg cgg cag gaa tcc tct tca tct      501
 Leu Glu Gly Leu Ile Val Gln Ser Arg Arg Gln Glu Ser Ser Ser Ser
      35                  40                  45

 ttc tca cca ata tgt ttt gtg gac tct gac gag cca aat ctg aca tca      549
 Phe Ser Pro Ile Cys Phe Val Asp Ser Asp Glu Pro Asn Leu Thr Ser
  50                  55                  60                  65

 gtt ctg gaa cat cta gaa gat act aag aac aac cat tca gtg aag aga      597
 Val Leu Glu His Leu Glu Asp Thr Lys Asn Asn His Ser Val Lys Arg
                  70                  75                  80

 gaa gcc aag cta ttt tct ctt ttc ctc atg aac att ata ttt aga aat      645
 Glu Ala Lys Leu Phe Ser Leu Phe Leu Met Asn Ile Ile Phe Arg Asn
              85                  90                  95

 taa atgt taagagataa tatgatataa tgttaagaga taatatgata taaaagcatg      702
 


 attaatgact ataaaaaaaa aaa                                            725




      <210> 45
      <211> 466
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (134)..(415)

      <400> 45
 tcgcctgcag taattcggca cgaggaagct gtcactgaaa tgaacttgat cttgatctgc     60

 tttgatatgg ggacagaatc cccgactgca ctattgaggg agtttcagaa gagaaggaag    120

 aggtgctgga agg   atg ctt ttg cag tca tgc agc aag gaa acg acc agg     169
                  Met Leu Leu Gln Ser Cys Ser Lys Glu Thr Thr Arg
                    1               5                  10

 gct gtg aag atc tac aga gga agt act cca gtg tgg ggg agg caa ggg      217
 Ala Val Lys Ile Tyr Arg Gly Ser Thr Pro Val Trp Gly Arg Gln Gly
          15                  20                  25

 aag agg acg aaa atg atg aga atg aca ctg agg tca ttg ttt aga gca      265
 Lys Arg Thr Lys Met Met Arg Met Thr Leu Arg Ser Leu Phe Arg Ala
      30                  35                  40

 gat ctc aag cag ccg ttt ggc cac gcc ata tcc ttt gtg gag cat agt      313
 Asp Leu Lys Gln Pro Phe Gly His Ala Ile Ser Phe Val Glu His Ser
  45                  50                  55                  60

 ggg tta tct atc tgt ctg tct gtc tat gta tct gac tat cta tct ata      361
 Gly Leu Ser Ile Cys Leu Ser Val Tyr Val Ser Asp Tyr Leu Ser Ile
                  65                  70                  75

 tat ata ttc agc ttc ttt act gct acc tac aca ttt ttc tcc aaa ttt      409
 Tyr Ile Phe Ser Phe Phe Thr Ala Thr Tyr Thr Phe Phe Ser Lys Phe
              80                  85                  90

 tat taa tttcatagtg ttttgatttg ggtggcagat gacttttaag cagtgggtgt       465
 Tyr 


 t                                                                    466




      <210> 46
      <211> 677
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (80)..(379)

      <400> 46
 cgagaggcgg gggcgctagg gccgagatca tgtctgactg ggagaggttt ccttggcagc     60

 agaggacgct aggtttggg atg aaa gaa gct ggg cag atg caa aat ctg gag     112
                      Met Lys Glu Ala Gly Gln Met Gln Asn Leu Glu
                        1               5                  10

 agc gcg agg gcc ggg cgg tca gtc agc acc cag act ggc agc atg acc      160
 Ser Ala Arg Ala Gly Arg Ser Val Ser Thr Gln Thr Gly Ser Met Thr
              15                  20                  25

 ggt cag ata cca agg ctt tct aaa gtc aac ctt ttc act ctg ctc agc      208
 Gly Gln Ile Pro Arg Leu Ser Lys Val Asn Leu Phe Thr Leu Leu Ser
          30                  35                  40

 ctc tgg atg gag ctc ttt cca gca gaa gcc cag cgg caa aaa tct cag      256
 Leu Trp Met Glu Leu Phe Pro Ala Glu Ala Gln Arg Gln Lys Ser Gln
      45                  50                  55

 aaa aat gaa gag gga aag cat gga ccc tta gga gat aat gaa gag agg      304
 Lys Asn Glu Glu Gly Lys His Gly Pro Leu Gly Asp Asn Glu Glu Arg
  60                  65                  70                  75

 acc aga gta tct act gac aaa aga cag aaa acc atg ttc tgc ttg ttt      352
 Thr Arg Val Ser Thr Asp Lys Arg Gln Lys Thr Met Phe Cys Leu Phe
                  80                  85                  90

 gaa aat gat tgt aaa tgc tgg agt taa ccgaa tttcatactg gcctgctgat      404
 Glu Asn Asp Cys Lys Cys Trp Ser 
              95

 ccagaaataa gtttgcttac ggaggcttct agttctgaag atgcaaagtt agatgccaaa    464

 gcagtggaaa gattgaagtc aaacagtcgg gcccatgtgt gtgtcttact tcaacctttg    524

 gtgtgttata tggtgcagtt tgtagaggag acctcttaca aatgtgactt tattcaaaaa    584

 attacaaaaa cattgccgga tgctaacact gacttttatt atgaatgtta acagaaagaa    644

 taacagaata tgacactgtt cacgaaaaaa aaa                                 677




      <210> 47
      <211> 1392
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (528)..(1226)

      <400> 47
 acctatctgt ccaagcagcc ggggttacag ggaattcact acataaagcc tctggtcttc     60

 cattatatag aaaggcgatg aagagacaag aaacaggtta aacagaaaaa cacgataatt    120

 tcacacataa ccactgccat atttaaagca ctgtacaccg gccctcggag ccagaattct    180

 ttccctcgag gttgccccag gaatcccttt gacctctgcc attggacgtc acagaaggcg    240

 cgactaatcg tggctggctc ccggagcttc actcttccct ctcttcctgc gaaacttgac    300

 acgccatttg tttctacgtc tgacatcctc ctcttttctc tggtccgtgg gagcttttgc    360

 aagcgggacc aggccccaac acccgaacca gcagcgagag aaggagcccg gcatgcggcg    420

 cactcagagt gacgacacac gcgagtctcc gcccgagtac gtcacttccg caacgcttcc    480

 ttcgcggcgc tttgtgggta gccgactggg gtctcctggc gacgacc  atg gcg ggg     536
                                                      Met Ala Gly
                                                        1

 gat gtg ggc ggt cgc agc tgc acg gac tcg gaa ctg ctg ctg cac ccg      584
 Asp Val Gly Gly Arg Ser Cys Thr Asp Ser Glu Leu Leu Leu His Pro
       5                  10                  15

 gag ctg ctg tcc cag gag ttc ctt ctc ctc act ctg gaa cag aag aac      632
 Glu Leu Leu Ser Gln Glu Phe Leu Leu Leu Thr Leu Glu Gln Lys Asn
  20                  25                  30                  35

 ata gct gtt gaa act gat gta aga gta aac aaa gac agt ctt act gac      680
 Ile Ala Val Glu Thr Asp Val Arg Val Asn Lys Asp Ser Leu Thr Asp
                  40                  45                  50

 ctt tat gtc caa cat gca ata cca ttg cct cag agg gat ttg ccg aag      728
 Leu Tyr Val Gln His Ala Ile Pro Leu Pro Gln Arg Asp Leu Pro Lys
              55                  60                  65

 aat aga tgg ggg aaa atg atg gaa aag aaa aga gaa caa cat gag att      776
 Asn Arg Trp Gly Lys Met Met Glu Lys Lys Arg Glu Gln His Glu Ile
          70                  75                  80

 aaa aat gag act aaa agg agt agc act gta gat ggg tta agg aaa aga      824
 Lys Asn Glu Thr Lys Arg Ser Ser Thr Val Asp Gly Leu Arg Lys Arg
      85                  90                  95

 ccc ctc atc gta ttt gat gga agt tca aca agt aca agc ata aaa gtg      872
 Pro Leu Ile Val Phe Asp Gly Ser Ser Thr Ser Thr Ser Ile Lys Val
 100                 105                 110                 115

 aaa aag aca gag aat gga gat aat gat cga ctg aag cct ccc ccg cag      920
 Lys Lys Thr Glu Asn Gly Asp Asn Asp Arg Leu Lys Pro Pro Pro Gln
                 120                 125                 130

 gca agc ttt acc agt aat gcc ttt aga aaa tta tca aat tcc tct tcg      968
 Ala Ser Phe Thr Ser Asn Ala Phe Arg Lys Leu Ser Asn Ser Ser Ser
             135                 140                 145

 agt gtt tca ccc cta att ttg tct tcc aat ttg cct gtg aac aat aaa     1016
 Ser Val Ser Pro Leu Ile Leu Ser Ser Asn Leu Pro Val Asn Asn Lys
         150                 155                 160

 acg gaa cac aat aat aat gac gct aaa cag aac cat gac tta acg cat     1064
 Thr Glu His Asn Asn Asn Asp Ala Lys Gln Asn His Asp Leu Thr His
     165                 170                 175

 agg aaa agt cct tca ggc cct gtg aag tcg cca cca ttg tcc cct gtt     1112
 Arg Lys Ser Pro Ser Gly Pro Val Lys Ser Pro Pro Leu Ser Pro Val
 180                 185                 190                 195

 gga act act cca gtg aag tta aag aga gct gct cct aaa gaa gag gca     1160
 Gly Thr Thr Pro Val Lys Leu Lys Arg Ala Ala Pro Lys Glu Glu Ala
                 200                 205                 210

 gag gcc atg aat aac ctg aag ccc cca caa gca aaa agg aag ata caa     1208
 Glu Ala Met Asn Asn Leu Lys Pro Pro Gln Ala Lys Arg Lys Ile Gln
             215                 220                 225

 cat gtt act tgg ccc tga agaaaa gtttccaaaa atgtaaatat actgtaactg     1262
 His Val Thr Trp Pro 
         230

 tagtttttca aatatgttca tatatattga caatatttac agaaatcctg attattgtgg   1322

 aattttctta agaggtttca aataggttta aaaaaataaa ggatttattt tccttccaaa   1382

 aaaaaaaaaa                                                          1392




      <210> 48
      <211> 1174
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(712)

      <400> 48
 tttcgtccgg gaagggctgg tggtcggggg cctagagcgg cggttgcact tagttgcggc     60

 tgctgtcacc   atg tcc cgc gtt ttg gtg cct tgc cat gtg aaa ggc tcc     109
              Met Ser Arg Val Leu Val Pro Cys His Val Lys Gly Ser
                1               5                  10

 gta gcc ctc cag gtg ggc gac gtg cgg acc tcc caa ggc cgg cct ggc      157
 Val Ala Leu Gln Val Gly Asp Val Arg Thr Ser Gln Gly Arg Pro Gly
      15                  20                  25

 gtg ctg gtc atc gat gtc acc ttc ccc agc gtc gct ccc ttc gag ttg      205
 Val Leu Val Ile Asp Val Thr Phe Pro Ser Val Ala Pro Phe Glu Leu
  30                  35                  40                  45

 cag gaa atc acg ttt aag aat tac tac aca gct ttt ttg agc atc cgt      253
 Gln Glu Ile Thr Phe Lys Asn Tyr Tyr Thr Ala Phe Leu Ser Ile Arg
                  50                  55                  60

 gtc cgt cag tac acc tca gca cac aca cct gcc aag tgg gtg acc tgc      301
 Val Arg Gln Tyr Thr Ser Ala His Thr Pro Ala Lys Trp Val Thr Cys
              65                  70                  75

 ctg cgg gac tac tgc cta atg cct gac cca cac agt gag gag gga gcc      349
 Leu Arg Asp Tyr Cys Leu Met Pro Asp Pro His Ser Glu Glu Gly Ala
          80                  85                  90

 cag gag tat gta tcg ctg ttc aag cat cag atg ctg tgt gac atg gct      397
 Gln Glu Tyr Val Ser Leu Phe Lys His Gln Met Leu Cys Asp Met Ala
      95                 100                 105

 aga ata tcg gag cta cgc ctg att ctg cgg cag cca tca cca ctg tgg      445
 Arg Ile Ser Glu Leu Arg Leu Ile Leu Arg Gln Pro Ser Pro Leu Trp
 110                 115                 120                 125

 ctg tct ttc aca gtg gag gag ctg cag atc tat cag cag gga cca aag      493
 Leu Ser Phe Thr Val Glu Glu Leu Gln Ile Tyr Gln Gln Gly Pro Lys
                 130                 135                 140

 agc ccc tcc gtg acc ttt ccc aag tgg ctc tcc cac cca gtg ccc tgt      541
 Ser Pro Ser Val Thr Phe Pro Lys Trp Leu Ser His Pro Val Pro Cys
             145                 150                 155

 gag caa cct gca ctc ctc cgt gag ggt ctc cca gac ccc agc agg gta      589
 Glu Gln Pro Ala Leu Leu Arg Glu Gly Leu Pro Asp Pro Ser Arg Val
         160                 165                 170

 tcc tcc gag gtg cag cag atg tgg gca ctg aca gag atg atc cgg gcc      637
 Ser Ser Glu Val Gln Gln Met Trp Ala Leu Thr Glu Met Ile Arg Ala
     175                 180                 185

 agt cac acc tcc gca agg atc ggc cgc ttt gat gtg gat ggc tgt tat      685
 Ser His Thr Ser Ala Arg Ile Gly Arg Phe Asp Val Asp Gly Cys Tyr
 190                 195                 200                 205

 gac ctg aac ttg ctc tcc tac act tga atggt tgctcctagc caagatgttg      737
 Asp Leu Asn Leu Leu Ser Tyr Thr 
                 210

 gcctttctgt gcccacccag acttggtttg ggccaccaga ggctgaagtg tatttcctgt    797

 gcattccaag tgttgcctgc atgcctgttc tgtctgggcc acattcacag attcaggatt    857

 ctcaggggct taccgtgtta cttcagcatg agctcctggc atgggggtgc tctgtcttcg    917

 cctggctgca actcaattct tccttctacc caaaaacact ccagtcagtt gtacttactg    977

 agaatccctg agtgccctct gccccttctg gcaacatgca cattcctgtc ttctgcctgc   1037

 tccctcatgt cagtgcagtt gggctgggct gacctactaa aacctgctcc atgtatggac   1097

 ctggaaggcc attgctgcca tggcacttgg gacacttgag gaagaaacag aaaccttatt   1157

 tcttaaaaaa aaaaaaa                                                  1174




      <210> 49
      <211> 1199
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(844)

      <400> 49
 cgcggacggt ggcgttaagg gaacgctgag gtcccgcgct ccccgaccga ggtatatctc     60

 c    atg aat aac cta aat gat ccc cca aat tgg aat atc cgg cct aat     106
      Met Asn Asn Leu Asn Asp Pro Pro Asn Trp Asn Ile Arg Pro Asn
        1               5                  10                  15

 tcc agg gcg gat ggt ggt gat gga agc agg tgg aat tat gcc ctg ttg      154
 Ser Arg Ala Asp Gly Gly Asp Gly Ser Arg Trp Asn Tyr Ala Leu Leu
                  20                  25                  30

 gtt cca atg ctg gga ttg gct gct ttt cgt tgg att tgg tct agg gag      202
 Val Pro Met Leu Gly Leu Ala Ala Phe Arg Trp Ile Trp Ser Arg Glu
              35                  40                  45

 tcc cag aaa gaa gta gaa aaa gag aga gaa gcc tac cgt cgg aga act      250
 Ser Gln Lys Glu Val Glu Lys Glu Arg Glu Ala Tyr Arg Arg Arg Thr
          50                  55                  60

 gct gct ttt caa cag gat ctg gaa gcc aag tac cac gcc atg atc tca      298
 Ala Ala Phe Gln Gln Asp Leu Glu Ala Lys Tyr His Ala Met Ile Ser
      65                  70                  75

 gaa aat cgg cgt gct gtc gct cag ttg tcc ttg gaa ctc gaa aag gaa      346
 Glu Asn Arg Arg Ala Val Ala Gln Leu Ser Leu Glu Leu Glu Lys Glu
  80                  85                  90                  95

 caa aac aga act gct agt tac cga gaa gcc ctt atc tct cag gga cgc      394
 Gln Asn Arg Thr Ala Ser Tyr Arg Glu Ala Leu Ile Ser Gln Gly Arg
                 100                 105                 110

 aag ttg gta gaa gaa aag aag ctt ctg gaa cag gaa cgg gcc cag gtg      442
 Lys Leu Val Glu Glu Lys Lys Leu Leu Glu Gln Glu Arg Ala Gln Val
             115                 120                 125

 atg caa gaa aaa aga cag gtg cag cct ttg aga agt gcg tat ttg agc      490
 Met Gln Glu Lys Arg Gln Val Gln Pro Leu Arg Ser Ala Tyr Leu Ser
         130                 135                 140

 tgc ctg caa agg gaa gaa aac tgg caa agg aga gcc agg ctt ttg ctg      538
 Cys Leu Gln Arg Glu Glu Asn Trp Gln Arg Arg Ala Arg Leu Leu Leu
     145                 150                 155

 aaa gaa ttt gaa gct gtt ctc aca gaa aga cag aat atc tac tgc agt      586
 Lys Glu Phe Glu Ala Val Leu Thr Glu Arg Gln Asn Ile Tyr Cys Ser
 160                 165                 170                 175

 ctg ttt ctt cct cgc agc aag cgg ctg gag ata gag aag agc tta ctg      634
 Leu Phe Leu Pro Arg Ser Lys Arg Leu Glu Ile Glu Lys Ser Leu Leu
                 180                 185                 190

 gtg cga gcg tcc gtc gac ccc gtc gcc gct gac cta gag atg gca gcc      682
 Val Arg Ala Ser Val Asp Pro Val Ala Ala Asp Leu Glu Met Ala Ala
             195                 200                 205

 ggt ctc acc gac ata ttt cag cat gat aca tac tgt ggt gat gtc tgg      730
 Gly Leu Thr Asp Ile Phe Gln His Asp Thr Tyr Cys Gly Asp Val Trp
         210                 215                 220

 aac acc aac aaa cgc cag aat ggc aga ctc atg tgg ctc tat ctc aaa      778
 Asn Thr Asn Lys Arg Gln Asn Gly Arg Leu Met Trp Leu Tyr Leu Lys
     225                 230                 235

 tac tgg gaa ctc gtt gtc gaa ctg aag aag ttt aag aga gta gag gaa      826
 Tyr Trp Glu Leu Val Val Glu Leu Lys Lys Phe Lys Arg Val Glu Glu
 240                 245                 250                 255

 gcc ata cta gaa aag taa gacaag agtgaaatca aactgctttt agtgactcga      880
 Ala Ile Leu Glu Lys 
                 260

 ggccaggcag tcatgcgcct tctgggtctc cggcgtcttc cgttcccgtg ctgcccgtgt    940

 catggccaca ccgtcaccct tcagcagcga cctccactcc cgccaccgtc tgagcagaag   1000

 tgcaccgaag cctcagagac agagggtctc ctcccgatgc tctgccgctg ttggggatat   1060

 ggtttcttga agcattttta ggctgccagt attgtattaa gcagaacagt ataacctcgt   1120

 attttagctc cagggtaaaa atggtttttt aaaaagtcaa atacaatact ggtccttacc   1180

 acaagtaaaa aaaaaaaaa                                                1199




      <210> 50
      <211> 1015
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (226)..(513)

      <400> 50
 tcactttata agtagctcag acgaactgag tatgaaatac cagtggctag agctaataat     60

 aacataaaag ttaaacctgt cataaagtgt cttatgtagg tgaaaacaga ggtggaaatt    120

 agcaactgtc ttatggagga gcgaagctga caacgctgga gacaatcgct tgcttcacca    180

 aagggccttg actaccgcta cccagtccgg ccccagcttt aggaa    atg ccg agg     234
                                                      Met Pro Arg
                                                        1

 tca cat cta ggg ggt cag ttt cca cca gag cac gag gct tgc cca aca      282
 Ser His Leu Gly Gly Gln Phe Pro Pro Glu His Glu Ala Cys Pro Thr
       5                  10                  15

 cct ccc tcc cca gag gct ggc aga cct caa aaa ccc cag agc atg aaa      330
 Pro Pro Ser Pro Glu Ala Gly Arg Pro Gln Lys Pro Gln Ser Met Lys
  20                  25                  30                  35

 gcc cca tgc ctc cca ccc cgg cag aaa aag gac aaa cta cac cat aaa      378
 Ala Pro Cys Leu Pro Pro Arg Gln Lys Lys Asp Lys Leu His His Lys
                  40                  45                  50

 cta cag aga gaa gct aac tgg ctg ctg ggc agt gtg aac aga cct aag      426
 Leu Gln Arg Glu Ala Asn Trp Leu Leu Gly Ser Val Asn Arg Pro Lys
              55                  60                  65

 ggt gaa aac cat tgc ccg aaa cat ttt cag ccc cac tca gca ggg aca      474
 Gly Glu Asn His Cys Pro Lys His Phe Gln Pro His Ser Ala Gly Thr
          70                  75                  80

 tgt gat tta cag gaa att agg agg ttt aca aaa tgt tag cagctcaagt       523
 Cys Asp Leu Gln Glu Ile Arg Arg Phe Thr Lys Cys 
      85                  90                  95

 ttcttccccg ggaaaagaag caggagaagc tctaagaacc gtatccgaga aagtgctttg    583

 ttcactgcta agcttctgac acgagtcagt tattaatacc cacagctcac tgcctcacac    643

 ttcaacccac cagtgaatgt ctatagtgaa taattataaa acaatatatt acaaaactct    703

 aacacaggct gcaccagagc cttccgaagc ccaggacagc cacgtggcca aaagcatgga    763

 cttcagatat gatcttgggc aagctgttgg ctctttttca ccccagttcc tccatccttt    823

 acaataaaca aaatccttct ggaggtgtct tgtcaagagg tgtcttgtca aatgatgagc    883

 aaatccactt caagtgcctg gtctttggaa gccctgttgg ttgctgttat tacagtggag    943

 tttcagagct cttaaagtca tatctccatc ttacttctgc tgccagacaa acctctggag   1003

 gccacgattc cg                                                       1015




      <210> 51
      <211> 949
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (348)..(536)

      <400> 51
 ctcaggaggg actcatgaac acgtgccctg agcaccccca aaatgacatc acacaagggc     60

 agaaaggagc tgaaggggga acgtgaaagg cagaaaggga gccgtggttg ccaggcaacc    120

 agccctagcc cacctttgtt tgtttggtga cagcaactaa ggtctggtca gggccgcttg    180

 gccacgctca tgccttttcc tctcaacagt tgcttctttg agtcagggtg cagctctggt    240

 cacctggcgg cctcttcagc tcagccctcc acaaagtgtg agcctgaagg accaccctga    300

 attgcccttg taggacccag aacagctacc agcagaatca gattctc  atg gac caa     356
                                                      Met Asp Gln
                                                        1

 ctg gta ttc aaa gag aca atc tgg aat gat gcg ttc tgg cag aac ccc      404
 Leu Val Phe Lys Glu Thr Ile Trp Asn Asp Ala Phe Trp Gln Asn Pro
       5                  10                  15

 tgg gac cag ggg ggc ctg gca gtg att atc tta ttc atc acc gct gtc      452
 Trp Asp Gln Gly Gly Leu Ala Val Ile Ile Leu Phe Ile Thr Ala Val
  20                  25                  30                  35

 ctg ctt ctc atc tta ttt gcc atc gtg ttt ggt tta ctc act tcc aca      500
 Leu Leu Leu Ile Leu Phe Ala Ile Val Phe Gly Leu Leu Thr Ser Thr
                  40                  45                  50

 gaa aac act cag tgt gaa gcg ggt gaa gag gag tga cctg acttgctggg      550
 Glu Asn Thr Gln Cys Glu Ala Gly Glu Glu Glu 
              55                  60

 gactgagatg gcagcagggg aggcgagctg acctgccccc attccagtgg tgggcccctt    610

 cgcggttccc tctggctcag gggccaagcc ctggtgtctt cctttcccac caggaaaaag    670

 tctagtaaaa tactgtatct ggcttagggt ggccaagact agaaacaggg gaagcctgtc    730

 cagagaccaa ttcgggcccc aagaccctat tgtttatagg ttccccgacc agaaccctaa    790

 aagcacatgg agagcatggc tccactgcca cagggggagg ggtctagtgc taactttttt    850

 ctggagcggg ctcacaggcg ccagccagca atttcacaaa tccttgacag agaaagacac    910

 aaccaaatga aataaaaacc ccttttcaaa aaaaaaaaa                           949




      <210> 52
      <211> 579
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (100)..(330)

      <400> 52
 tcagaacgtc accacgtctg gccaatgaaa tgatgtatac taatcttttc catcaattga     60

 aacttcttaa gactgttttc atccaaagca aaaacaggg   atg ggt agg aat ttc     114
                                              Met Gly Arg Asn Phe
                                                1               5

 cta tcc caa tcc ctt tgc tgg aat att ata gac acc tat cta agg gta      162
 Leu Ser Gln Ser Leu Cys Trp Asn Ile Ile Asp Thr Tyr Leu Arg Val
                  10                  15                  20

 tat ttg ttt tgg ctt att ttt caa aat aag cca ttc tgg tgt cag gga      210
 Tyr Leu Phe Trp Leu Ile Phe Gln Asn Lys Pro Phe Trp Cys Gln Gly
              25                  30                  35

 gca gtt act ctt cta aaa ata tgc tgg caa ctt tat ttc tat aaa acc      258
 Ala Val Thr Leu Leu Lys Ile Cys Trp Gln Leu Tyr Phe Tyr Lys Thr
          40                  45                  50

 ttc cag caa aag agg ctg tta tat gct cta aat att ttc att ttg ttt      306
 Phe Gln Gln Lys Arg Leu Leu Tyr Ala Leu Asn Ile Phe Ile Leu Phe
      55                  60                  65

 aac agt ttt agc tta cgg gga tga ggcaactttc aagaagtttt atgaagtcag     360
 Asn Ser Phe Ser Leu Arg Gly 
  70                  75

 acacagaggt accaatttac acatattata tataatcaga atacaccaga aaaaaacaaa    420

 actctcatgg ttcctatact agggaaaggt ttcctattaa ataagtgtta ggcaatcaat    480

 tgcacacact tcataaaact tcataagtaa acaatgggat taaacgtgac tgtatactag    540

 taatttccaa gtcctgggta agagtttctg ctcgtgccg                           579




      <210> 53
      <211> 1113
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(908)

      <400> 53
 cggaagcggg ggtgcagcgc ggcaga atg agg gtt gat tcc tcg gct gac ccc      53
                              Met Arg Val Asp Ser Ser Ala Asp Pro
                                1               5

 aca atg tcg cag gag caa ggg ccg ggg tcc tcc acg cct ccc agt tct      101
 Thr Met Ser Gln Glu Gln Gly Pro Gly Ser Ser Thr Pro Pro Ser Ser
  10                  15                  20                  25

 ccg aca ctt ctt gac gct ctg ctc cag aac ctt tac gac ttt gga ggt      149
 Pro Thr Leu Leu Asp Ala Leu Leu Gln Asn Leu Tyr Asp Phe Gly Gly
                  30                  35                  40

 aca gaa ggt gaa aca gaa cag aag aag atc ata aag aaa agg gaa aac      197
 Thr Glu Gly Glu Thr Glu Gln Lys Lys Ile Ile Lys Lys Arg Glu Asn
              45                  50                  55

 aag aag aga gat gtg atg gct tca gcg gcc ttg gca gca gag cca tct      245
 Lys Lys Arg Asp Val Met Ala Ser Ala Ala Leu Ala Ala Glu Pro Ser
          60                  65                  70

 ccc cta cct ggt tct ctc ata aga ggc cag agg aag agc gct tcg agc      293
 Pro Leu Pro Gly Ser Leu Ile Arg Gly Gln Arg Lys Ser Ala Ser Ser
      75                  80                  85

 ttc ttc aag gaa ctt aga gaa gag cgg cat tgt gct cct tct ggg acc      341
 Phe Phe Lys Glu Leu Arg Glu Glu Arg His Cys Ala Pro Ser Gly Thr
  90                  95                 100                 105

 ccc aca gga cca gag atc ctt gct gct gca gtt cct ccc tct tcc cta      389
 Pro Thr Gly Pro Glu Ile Leu Ala Ala Ala Val Pro Pro Ser Ser Leu
                 110                 115                 120

 aag aac aat agg gaa caa gta gaa gtg gta gaa ttt cac agc aat aaa      437
 Lys Asn Asn Arg Glu Gln Val Glu Val Val Glu Phe His Ser Asn Lys
             125                 130                 135

 aaa aga aaa ttg acg cca gat cat aac aag aac aca aag cag gct aat      485
 Lys Arg Lys Leu Thr Pro Asp His Asn Lys Asn Thr Lys Gln Ala Asn
         140                 145                 150

 cct agt gtt ttg gag aga gat gtg gat aca caa gaa ttt aac cta gaa      533
 Pro Ser Val Leu Glu Arg Asp Val Asp Thr Gln Glu Phe Asn Leu Glu
     155                 160                 165

 aaa gct cgt tta gaa gtg cac cgg ttt ggt atc acg ggt tat gga aaa      581
 Lys Ala Arg Leu Glu Val His Arg Phe Gly Ile Thr Gly Tyr Gly Lys
 170                 175                 180                 185

 gga aag gag aga atc ctg gaa cag gaa cgt gcc att atg ctg ggc gct      629
 Gly Lys Glu Arg Ile Leu Glu Gln Glu Arg Ala Ile Met Leu Gly Ala
                 190                 195                 200

 aag cct cct aaa aag agt tat gtg aat tac aag gtt tta cag gag caa      677
 Lys Pro Pro Lys Lys Ser Tyr Val Asn Tyr Lys Val Leu Gln Glu Gln
             205                 210                 215

 att aaa gaa aaa aag gca gca aag gaa gaa gaa aag aga ctg gcc caa      725
 Ile Lys Glu Lys Lys Ala Ala Lys Glu Glu Glu Lys Arg Leu Ala Gln
         220                 225                 230

 gaa aca gat att ttc aag aaa aag aag agg aaa gga cag gag gac agg      773
 Glu Thr Asp Ile Phe Lys Lys Lys Lys Arg Lys Gly Gln Glu Asp Arg
     235                 240                 245

 aaa tcc aaa aag aag tcc gct ccc agt att ttg tca aat gga cgg att      821
 Lys Ser Lys Lys Lys Ser Ala Pro Ser Ile Leu Ser Asn Gly Arg Ile
 250                 255                 260                 265

 gga cag gtt gga aaa ttc aaa aat gga aca ctg att ctg agc cca gtt      869
 Gly Gln Val Gly Lys Phe Lys Asn Gly Thr Leu Ile Leu Ser Pro Val
                 270                 275                 280

 gat atc aag aaa ata aat tct tcc aga gtg gcc aaa tga agtactttgt       918
 Asp Ile Lys Lys Ile Asn Ser Ser Arg Val Ala Lys 
             285                 290

 caaataaaac gaggatgggg tacaactgag tcaactgcag cggcctggga cctgtgcgat    978

 tctagtagtt cttcttaaca cgctttcaca gatgcttttt cttttaggat aaagtcaatc   1038

 gtagttactt ttagttgccg agttttgctt cttgtcttga cgttcggccc gttcggctgt   1098

 tgtgagtgac cattt                                                    1113




      <210> 54
      <211> 566
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (137)..(361)

      <400> 54
 gacatttatc attataacat cttattagag cccctaattt cttatctgaa ggcactgttt     60

 ttttttttaa acagttaagt actgatgtca acagacaaat atttctgatc aaatagtccc    120

 ctgtcaacag tagcaa    atg tgg ttt cat aaa ggg gga aga aaa cag cat     169
                      Met Trp Phe His Lys Gly Gly Arg Lys Gln His
                        1               5                  10

 ttt aaa gta act ttt tgg gag act gat ttg agt aat aat aaa act ctg      217
 Phe Lys Val Thr Phe Trp Glu Thr Asp Leu Ser Asn Asn Lys Thr Leu
              15                  20                  25

 gtc tcc ctt aaa aaa aaa aaa ccc ttc cac ctt tac tgt gtc att tat      265
 Val Ser Leu Lys Lys Lys Lys Pro Phe His Leu Tyr Cys Val Ile Tyr
          30                  35                  40

 atc ccc tta gtt cca aag tta att atc tta ttt ctg gat att gct ttt      313
 Ile Pro Leu Val Pro Lys Leu Ile Ile Leu Phe Leu Asp Ile Ala Phe
      45                  50                  55

 ata cca aag acc ctt atc agc cct tgt aac tac agt atc ttt aga taa      361
 Ile Pro Lys Thr Leu Ile Ser Pro Cys Asn Tyr Ser Ile Phe Arg 
  60                  65                  70

 gattcctctt tccagtcagt cctgggaaat gtttctgttg cagagttagg cggtagatgg    421

 gaagctgtga tggcagagct actatctaat aaagtaacaa ctcgtagttg aggcttcctt    481

 tctgtgtgtg atgggggata gggagttagc tcccctgttg tctcagcact aagaaattga    541

 ggtcaggcca gcgtcgacgc ggccg                                          566




      <210> 55
      <211> 649
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (378)..(617)

      <400> 55
 agccagtcat ttctgcatgg agagacttct catactttct ttgaagactc atagaaagct     60

 ggatctagag cttttgaatc cgttaattag cacagtagaa attagctttc tatgggaatg    120

 ctttagtgtt agcagttgac aattaggccc atattcaatc tgaatgggaa caaaagtaaa    180

 tgcaatgata atatactggt agttagagaa acatgttagt tgattatacc tgaaatggat    240

 tatttatctc atcagcaagt attatttgaa taaaatgaga aatgcttaag aaaaattgtt    300

 gctctatagt aatttggttt cgaagaatgg aatggtaact attttttccc atcgttcttt    360

 tgagagaagg aagtgtg   atg act gat gat ctt gaa aag ccc att tct gat     410
                      Met Thr Asp Asp Leu Glu Lys Pro Ile Ser Asp
                        1               5                  10

 tgc acg ttg act gga att ctt tct ttg tgt ctg tgg act agc gat gct      458
 Cys Thr Leu Thr Gly Ile Leu Ser Leu Cys Leu Trp Thr Ser Asp Ala
              15                  20                  25

 gtt tgt aaa atg aag att cgg gac tgg ctc ata tct ttt tat cta act      506
 Val Cys Lys Met Lys Ile Arg Asp Trp Leu Ile Ser Phe Tyr Leu Thr
          30                  35                  40

 aga tgt cag atc ttg aaa tct gta ttc tcg aag caa ttc tgc cac ttg      554
 Arg Cys Gln Ile Leu Lys Ser Val Phe Ser Lys Gln Phe Cys His Leu
      45                  50                  55

 atc gta ttc aca ggg gcc ctg gta ggc tcc ttt aga agg acc att tct      602
 Ile Val Phe Thr Gly Ala Leu Val Gly Ser Phe Arg Arg Thr Ile Ser
  60                  65                  70                  75

 gtt cct aga gct taa ctagaattca ttcttcactg aaaaaaaaaa aa              649
 Val Pro Arg Ala 






      <210> 56
      <211> 994
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (692)..(856)

      <400> 56
 ggaaatagag ccagacatta tgtgaaaagt gacacctgtc tgatgtcatt tggccttttg     60

 gccatgcctg ttcagtaatt tgtttttgag tataaaaaag gtatcttctc tattcttgaa    120

 ttgtgagatt gtggaaattg gaatccagtc ttatcatcat ctctaagtga taccagataa    180

 cttggctttg caagctccca tgcaggattc ttttgtctgt gtgacataag tattaaaatg    240

 tgtcctgcct tataaagaat gtgaattcca tattctcact tggtatcagt gagaaatatt    300

 cccatatttc tatttgcaac atagaagata atgcatcatg tccttctggg gcatggcaag    360

 ttctaaatga attcctggca gagcaatgga ttctgtgatt gactatgtgg tgtagttgtt    420

 gctaagagga tgctattgta atcttttcta cctatacttc ttcattggct cagaatgaag    480

 caaggcatgt gctgctttct tatatgtcat ttatgccata aatcccattg ttagaaggta    540

 atgcttctaa cggattccat tcatgctttt gagataaatg gcattgactt tcatattgat    600

 cacatggaaa gctgttacct gattcctttc ctgagatcac ttccagccta atgtgcattt    660

 ggctggaata tggttgtctc agaataacat c   atg cac tcg ggc ttt tat act     712
                                      Met His Ser Gly Phe Tyr Thr
                                        1               5

 tct gcc ttt agg gga ctg tgg cag cat ggc atg ggt caa gaa gta ctt      760
 Ser Ala Phe Arg Gly Leu Trp Gln His Gly Met Gly Gln Glu Val Leu
          10                  15                  20

 ctc ctt cat ctt cct ttg atg tcg gta act cat cct ttc tgc act gcg      808
 Leu Leu His Leu Pro Leu Met Ser Val Thr His Pro Phe Cys Thr Ala
      25                  30                  35

 gga gtt gtt aat gct ttt gtg tcc tcc agt tca cat gct gat tgc taa      856
 Gly Val Val Asn Ala Phe Val Ser Ser Ser Ser His Ala Asp Cys 
  40                  45                  50

 gaagaaaatg agcatgagtg aacccaaagc tgctgaaaca ttctgcgttt atgcaacttc    916

 cttgccctct atacaaggaa gatggtttca ttgtcttgtc tagagaataa agtctttttt    976

 aaaaataaaa aaaaaaaa                                                  994




      <210> 57
      <211> 4224
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (634)..(4224)

      <400> 57
 gttcaaacac tgcattttct tactcaaaga tcttctcaaa actcccctga aaaaaccact     60

 ctggctgcaa agttatctgc taagaaacag gcatccatat acagagatga aaatgatgat    120

 tttcaagtag agaagaaaag aattcgaccc ttagaaacta cacagcagat tagaaaacgt    180

 cattgctttg gaacagaagt acacaatttg gatgcaaaag ttgattcagg aaagactgta    240

 aaactcaact ctccactgga aaagataaac tccttttcgc cacagaaaac cagtacggtg    300

 gccgacggga gtcagacgct ggggatgaat gaaggtgctg ggtgcaggtt gaaaaagtct    360

 cccgcttttc cgttcctaca gtcccggttc tgcctttgtg tggtgccccc atccttccca    420

 ctttgtatcg acaacccggt tggtcccggc gtctgagttc ttggtgtccg agtcgactcg    480

 aggcacaact agggtttggg gttccggata tcgcctaggc ccaacatcgg accgcgctct    540

 cgatttctgc cgcgtcccgc ctctaggacg cggagtccgt gtgcggttcc gtgaggctgg    600

 agggtagatc ttaaggatca acaaacagta ata atg act gaa tgt aca agt ctt     654
                                      Met Thr Glu Cys Thr Ser Leu
                                        1               5

 cag ttt gtc agc cct ttt gct ttt gag gca atg cag aag gtg gat gtt      702
 Gln Phe Val Ser Pro Phe Ala Phe Glu Ala Met Gln Lys Val Asp Val
          10                  15                  20

 gtt tgc ctg gca tct tta agt gat cca gaa tta aga ctt ctt ctg ccc      750
 Val Cys Leu Ala Ser Leu Ser Asp Pro Glu Leu Arg Leu Leu Leu Pro
      25                  30                  35

 tgt ttg gta cgg atg gca ctt tgt gca cct gct gac cag agc caa agc      798
 Cys Leu Val Arg Met Ala Leu Cys Ala Pro Ala Asp Gln Ser Gln Ser
  40                  45                  50                  55

 tgg gct cag gat aag aaa ctc atc ctt cgc ctt ctt tct gga gtg gaa      846
 Trp Ala Gln Asp Lys Lys Leu Ile Leu Arg Leu Leu Ser Gly Val Glu
                  60                  65                  70

 gct gtc aac tcc att gtt gca ttg ttg tcc gtg gac ttt cat gct tta      894
 Ala Val Asn Ser Ile Val Ala Leu Leu Ser Val Asp Phe His Ala Leu
              75                  80                  85

 gaa caa gat gcc agc aaa gaa cag cag ctt agg cat aaa ctt gga gga      942
 Glu Gln Asp Ala Ser Lys Glu Gln Gln Leu Arg His Lys Leu Gly Gly
          90                  95                 100

 ggc agt gga gag agc atc ctg gta tca cag ctt cag cat gga ctg acg      990
 Gly Ser Gly Glu Ser Ile Leu Val Ser Gln Leu Gln His Gly Leu Thr
     105                 110                 115

 tta gag ttt gaa cac agt gat tca cct cgt cga ttg cgt ctt gtg ctt     1038
 Leu Glu Phe Glu His Ser Asp Ser Pro Arg Arg Leu Arg Leu Val Leu
 120                 125                 130                 135

 agt gaa ctg ttg gca att atg aac aag gtg tct gag tcc aac gga gaa     1086
 Ser Glu Leu Leu Ala Ile Met Asn Lys Val Ser Glu Ser Asn Gly Glu
                 140                 145                 150

 ttt ttt ttc aag tct tct gaa ctt ttt gag agt cca gta tat ttg gag     1134
 Phe Phe Phe Lys Ser Ser Glu Leu Phe Glu Ser Pro Val Tyr Leu Glu
             155                 160                 165

 gaa gct gca gat gta ctt tgt att tta caa gca gag ctc cct tcc ttg     1182
 Glu Ala Ala Asp Val Leu Cys Ile Leu Gln Ala Glu Leu Pro Ser Leu
         170                 175                 180

 ctc cct ata gtt gat gta gct gaa gct ttg cta cat gtt aga aat ggt     1230
 Leu Pro Ile Val Asp Val Ala Glu Ala Leu Leu His Val Arg Asn Gly
     185                 190                 195

 gcc tgg ttc ttg tgt ctc ttg gtg gcc aat gtt cct gat agt ttt aat     1278
 Ala Trp Phe Leu Cys Leu Leu Val Ala Asn Val Pro Asp Ser Phe Asn
 200                 205                 210                 215

 gaa gtt tgt agg ggc ctg ata aaa aat gga gaa cga caa gat gaa gaa     1326
 Glu Val Cys Arg Gly Leu Ile Lys Asn Gly Glu Arg Gln Asp Glu Glu
                 220                 225                 230

 agt ctt gga gga agg cgc agg aca gat gcc tta cgc ttc ttg tgt aaa     1374
 Ser Leu Gly Gly Arg Arg Arg Thr Asp Ala Leu Arg Phe Leu Cys Lys
             235                 240                 245

 atg aat cct tct cag gcc ctc aag gtc cga ggc atg gtg gtg gaa gaa     1422
 Met Asn Pro Ser Gln Ala Leu Lys Val Arg Gly Met Val Val Glu Glu
         250                 255                 260

 tgt cac ttg cca ggc ctt ggt gtg gct ttg aca ttg gat cat act aaa     1470
 Cys His Leu Pro Gly Leu Gly Val Ala Leu Thr Leu Asp His Thr Lys
     265                 270                 275

 aat gaa gct tgt gag gat gga gtg agt gac ttg gtt tgt ttt gta agt     1518
 Asn Glu Ala Cys Glu Asp Gly Val Ser Asp Leu Val Cys Phe Val Ser
 280                 285                 290                 295

 ggt ttg ctt ctt gga aca aat gcg aaa gtc cgg act tgg ttt gga act     1566
 Gly Leu Leu Leu Gly Thr Asn Ala Lys Val Arg Thr Trp Phe Gly Thr
                 300                 305                 310

 ttt atc cga aat gga cag cag aga aaa aga gag acc agc agt tct gtc     1614
 Phe Ile Arg Asn Gly Gln Gln Arg Lys Arg Glu Thr Ser Ser Ser Val
             315                 320                 325

 ctt tgg cag atg aga agg cag ctt ctt ctg gag ttg atg ggc att ctt     1662
 Leu Trp Gln Met Arg Arg Gln Leu Leu Leu Glu Leu Met Gly Ile Leu
         330                 335                 340

 ccc aca gta aga agc acc cga att gtg gaa gaa gct gat gtg gat atg     1710
 Pro Thr Val Arg Ser Thr Arg Ile Val Glu Glu Ala Asp Val Asp Met
     345                 350                 355

 gag ccc aat gtg tct gtg tat tcg ggg ctg aaa gaa gag cat gtt gtg     1758
 Glu Pro Asn Val Ser Val Tyr Ser Gly Leu Lys Glu Glu His Val Val
 360                 365                 370                 375

 aaa gcc agt gca ctc tta cgt ctg tac tgt gct ttg atg ggg atc gct     1806
 Lys Ala Ser Ala Leu Leu Arg Leu Tyr Cys Ala Leu Met Gly Ile Ala
                 380                 385                 390

 gga ctc aaa cca act gaa gaa gaa gct gag caa tta ctg cag ttg atg     1854
 Gly Leu Lys Pro Thr Glu Glu Glu Ala Glu Gln Leu Leu Gln Leu Met
             395                 400                 405

 acg agc cgt cct cct gct acg cca gct ggg gtt cgc ttt gtt tca ctt     1902
 Thr Ser Arg Pro Pro Ala Thr Pro Ala Gly Val Arg Phe Val Ser Leu
         410                 415                 420

 tcc ttt tgt atg cta ctg gcc ttt tct aca ctt gtc agt aca cct gaa     1950
 Ser Phe Cys Met Leu Leu Ala Phe Ser Thr Leu Val Ser Thr Pro Glu
     425                 430                 435

 cag gag cag ctg atg gtg gtg tgg cta agt tgg atg ata aaa gaa gaa     1998
 Gln Glu Gln Leu Met Val Val Trp Leu Ser Trp Met Ile Lys Glu Glu
 440                 445                 450                 455

 gcg tat ttt gag agt act tca ggc gtc tct gct tct ttt ggg gag atg     2046
 Ala Tyr Phe Glu Ser Thr Ser Gly Val Ser Ala Ser Phe Gly Glu Met
                 460                 465                 470

 tta tta ttg gtg gct atg tac ttt cac agc aac cag ctt agt gct atc     2094
 Leu Leu Leu Val Ala Met Tyr Phe His Ser Asn Gln Leu Ser Ala Ile
             475                 480                 485

 att gac ttg gtc tgt tcc act ttg ggg atg aag att gta att aag cca     2142
 Ile Asp Leu Val Cys Ser Thr Leu Gly Met Lys Ile Val Ile Lys Pro
         490                 495                 500

 agc tcc ttg agc agg atg aag aca atc ttc aca cag gaa att ttt act     2190
 Ser Ser Leu Ser Arg Met Lys Thr Ile Phe Thr Gln Glu Ile Phe Thr
     505                 510                 515

 gag cag gtt gtc aca gct cat gca gtt cgg gtc cct gtc acc agc aac     2238
 Glu Gln Val Val Thr Ala His Ala Val Arg Val Pro Val Thr Ser Asn
 520                 525                 530                 535

 ctg agt gcc aac att act gga ttt ttg cct att cat tgt att tac cag     2286
 Leu Ser Ala Asn Ile Thr Gly Phe Leu Pro Ile His Cys Ile Tyr Gln
                 540                 545                 550

 ctt ctc agg agc cgt tcc ttt acc aag cac aaa gtg tca ata aaa gat     2334
 Leu Leu Arg Ser Arg Ser Phe Thr Lys His Lys Val Ser Ile Lys Asp
             555                 560                 565

 tgg att tat aga cag ctg tgt gaa acc tct act cca ctt cat cct caa     2382
 Trp Ile Tyr Arg Gln Leu Cys Glu Thr Ser Thr Pro Leu His Pro Gln
         570                 575                 580

 tta ctt cct ttg att gat gtg tac ata aat tct ata ctt act cct gcg     2430
 Leu Leu Pro Leu Ile Asp Val Tyr Ile Asn Ser Ile Leu Thr Pro Ala
     585                 590                 595

 tcg aaa tct aat cca gaa gcc aca aat cag cca gtc aca gaa cag gag     2478
 Ser Lys Ser Asn Pro Glu Ala Thr Asn Gln Pro Val Thr Glu Gln Glu
 600                 605                 610                 615

 ata ctc aat att ttc caa gga gtc att ggg ggt gac aac atc cgc ctt     2526
 Ile Leu Asn Ile Phe Gln Gly Val Ile Gly Gly Asp Asn Ile Arg Leu
                 620                 625                 630

 aat cag cgt ttc agt atc aca gca cag ctt ttg gtg ctc tac tat ata     2574
 Asn Gln Arg Phe Ser Ile Thr Ala Gln Leu Leu Val Leu Tyr Tyr Ile
             635                 640                 645

 ctg tct tat gaa gag gct ctt cta gca aac acg aag act tta gct gcc     2622
 Leu Ser Tyr Glu Glu Ala Leu Leu Ala Asn Thr Lys Thr Leu Ala Ala
         650                 655                 660

 atg caa aga aag ccc aaa tca tat tct tct tct tta atg gat cag att     2670
 Met Gln Arg Lys Pro Lys Ser Tyr Ser Ser Ser Leu Met Asp Gln Ile
     665                 670                 675

 cct atc aaa ttc ctt att cga cag gct caa ggg ctg cag cag gag ttg     2718
 Pro Ile Lys Phe Leu Ile Arg Gln Ala Gln Gly Leu Gln Gln Glu Leu
 680                 685                 690                 695

 gga ggg ttg cat tca gct tta cta cgt ctc ctt gct act aac tac cca     2766
 Gly Gly Leu His Ser Ala Leu Leu Arg Leu Leu Ala Thr Asn Tyr Pro
                 700                 705                 710

 cat tta tgt att gtg gat gac tgg att tgt gaa gaa gaa atc aca ggg     2814
 His Leu Cys Ile Val Asp Asp Trp Ile Cys Glu Glu Glu Ile Thr Gly
             715                 720                 725

 act gat gcc ctg cta cgg cga atg ctc ctg act aat aat gct aaa aat     2862
 Thr Asp Ala Leu Leu Arg Arg Met Leu Leu Thr Asn Asn Ala Lys Asn
         730                 735                 740

 cat tct ccc aaa caa ctc caa gaa gca ttt tca gct gtc cca gta aat     2910
 His Ser Pro Lys Gln Leu Gln Glu Ala Phe Ser Ala Val Pro Val Asn
     745                 750                 755

 cac aca caa gtg atg cag att ata gaa cac ttg act cta ctc tct gcc     2958
 His Thr Gln Val Met Gln Ile Ile Glu His Leu Thr Leu Leu Ser Ala
 760                 765                 770                 775

 agt gaa ctt ata cca tat gcg gaa gtg tta aca tcc aat atg agc cag     3006
 Ser Glu Leu Ile Pro Tyr Ala Glu Val Leu Thr Ser Asn Met Ser Gln
                 780                 785                 790

 cta ttg aat tca ggg gtt cca cgg aga att ctg caa aca gtc aat aaa     3054
 Leu Leu Asn Ser Gly Val Pro Arg Arg Ile Leu Gln Thr Val Asn Lys
             795                 800                 805

 cta tgg atg gtt ctt aat act gtg atg cct aga agg cta tgg tta atg     3102
 Leu Trp Met Val Leu Asn Thr Val Met Pro Arg Arg Leu Trp Leu Met
         810                 815                 820

 acg gtt aat gca ctt cag cct tca ata aag ttt gta cga caa caa aag     3150
 Thr Val Asn Ala Leu Gln Pro Ser Ile Lys Phe Val Arg Gln Gln Lys
     825                 830                 835

 tat act cag aat gac ctg atg ata gat cct ctc att gtc cta agg tgt     3198
 Tyr Thr Gln Asn Asp Leu Met Ile Asp Pro Leu Ile Val Leu Arg Cys
 840                 845                 850                 855

 gat cag agg gtt cac aga tgc ccc cca ctg atg gat att acc cta cac     3246
 Asp Gln Arg Val His Arg Cys Pro Pro Leu Met Asp Ile Thr Leu His
                 860                 865                 870

 atg ttg aat gga tat ctt ctt gca tct aaa gcc tac ctt agt gct cat     3294
 Met Leu Asn Gly Tyr Leu Leu Ala Ser Lys Ala Tyr Leu Ser Ala His
             875                 880                 885

 ctg aag gaa aca gag caa gat agg cct tcc cag aat aat aca att ggt     3342
 Leu Lys Glu Thr Glu Gln Asp Arg Pro Ser Gln Asn Asn Thr Ile Gly
         890                 895                 900

 tta gtt gga caa act gat gct ccg gaa gtt acc agg gaa gaa ttg aaa     3390
 Leu Val Gly Gln Thr Asp Ala Pro Glu Val Thr Arg Glu Glu Leu Lys
     905                 910                 915

 aat gca tta ctg gcc gct cag gat agt gca gct gtc cag att ctc tta     3438
 Asn Ala Leu Leu Ala Ala Gln Asp Ser Ala Ala Val Gln Ile Leu Leu
 920                 925                 930                 935

 gag att tgc cta cct act gaa gag gag aaa gca aat ggt gtc aat cca     3486
 Glu Ile Cys Leu Pro Thr Glu Glu Glu Lys Ala Asn Gly Val Asn Pro
                 940                 945                 950

 gat agc ttg tta aga aat gtt caa agt gtt att acc acc agc gct cca     3534
 Asp Ser Leu Leu Arg Asn Val Gln Ser Val Ile Thr Thr Ser Ala Pro
             955                 960                 965

 aat aag gga atg gag gaa gga gaa gac aat ttg ctc tgt aac ctt cga     3582
 Asn Lys Gly Met Glu Glu Gly Glu Asp Asn Leu Leu Cys Asn Leu Arg
         970                 975                 980

 gaa gtt cag tgc ctt atc tgt tgt ctc ttg cac caa atg tac att gca     3630
 Glu Val Gln Cys Leu Ile Cys Cys Leu Leu His Gln Met Tyr Ile Ala
     985                 990                 995

 gat ccc aac att gct aag ctt gtt cac ttt cag ggt tat cca tgt gaa     3678
 Asp Pro Asn Ile Ala Lys Leu Val His Phe Gln Gly Tyr Pro Cys Glu
1000                1005                1010                1015

 ctt ttg cct ctg acg gtc gca ggt att cca tct atg cac atc tgt cta     3726
 Leu Leu Pro Leu Thr Val Ala Gly Ile Pro Ser Met His Ile Cys Leu
                1020                1025                1030

 gat ttc ata cct gag ctt att gca cag cca gaa ctt gag aaa cag ata     3774
 Asp Phe Ile Pro Glu Leu Ile Ala Gln Pro Glu Leu Glu Lys Gln Ile
            1035                1040                1045

 ttt gct atc cag ttg ctt tct cac ttg tgt ata caa tat gca tta cca     3822
 Phe Ala Ile Gln Leu Leu Ser His Leu Cys Ile Gln Tyr Ala Leu Pro
        1050                1055                1060

 aag tca ctt agt gtg gct cgt tta gct gtc aat gtc atg gga act ttg     3870
 Lys Ser Leu Ser Val Ala Arg Leu Ala Val Asn Val Met Gly Thr Leu
    1065                1070                1075

 tta aca gtt tta aca cag gct aag cgg tat gct ttt ttt atg cca act     3918
 Leu Thr Val Leu Thr Gln Ala Lys Arg Tyr Ala Phe Phe Met Pro Thr
1080                1085                1090                1095

 ctg cca agt ttg gtc tct ttt tgt cga gca ttt cct cca ttg tat gag     3966
 Leu Pro Ser Leu Val Ser Phe Cys Arg Ala Phe Pro Pro Leu Tyr Glu
                1100                1105                1110

 gat att atg tct ttg ctg atc caa ata ggg caa gtt tgt gcc tct gat     4014
 Asp Ile Met Ser Leu Leu Ile Gln Ile Gly Gln Val Cys Ala Ser Asp
            1115                1120                1125

 gtt gcc act cag aca aga gac att gat cca att att aca cgt ctt caa     4062
 Val Ala Thr Gln Thr Arg Asp Ile Asp Pro Ile Ile Thr Arg Leu Gln
        1130                1135                1140

 caa ata aag gag aaa cca agt gga tgg tct caa atc tgt aaa gat tca     4110
 Gln Ile Lys Glu Lys Pro Ser Gly Trp Ser Gln Ile Cys Lys Asp Ser
    1145                1150                1155

 tct tat aaa aat gga tcc agg gac act gga agc atg gat cct gat gta     4158
 Ser Tyr Lys Asn Gly Ser Arg Asp Thr Gly Ser Met Asp Pro Asp Val
1160                1165                1170                1175

 cag ctc tgt cac tgt att gaa aga aca gta att gaa ata ata aat atg     4206
 Gln Leu Cys His Cys Ile Glu Arg Thr Val Ile Glu Ile Ile Asn Met
                1180                1185                1190

 agt gtt agt gga att taa                                             4224
 Ser Val Ser Gly Ile 
            1195





      <210> 58
      <211> 560
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (15)..(362)

      <400> 58
 gcgagggcag gact  atg gga ggc tgc cct gta cgg aaa aga aga aga aat      50
                  Met Gly Gly Cys Pro Val Arg Lys Arg Arg Arg Asn
                    1               5                  10

 ggc agt aaa gag ggc aac cat cat tcc acc cag ccc aaa agg aat aag       98
 Gly Ser Lys Glu Gly Asn His His Ser Thr Gln Pro Lys Arg Asn Lys
          15                  20                  25

 aga aac cct atc ttt cag gat tct caa gat aca gag ttt tca tgg agt      146
 Arg Asn Pro Ile Phe Gln Asp Ser Gln Asp Thr Glu Phe Ser Trp Ser
      30                  35                  40

 gat aat gaa agg agc agc agc cgc att aat atc cca gag aga gca agt      194
 Asp Asn Glu Arg Ser Ser Ser Arg Ile Asn Ile Pro Glu Arg Ala Ser
  45                  50                  55                  60

 gga cca gaa ggc aac tta aac cag att gtt act gaa ccc gat gca aac      242
 Gly Pro Glu Gly Asn Leu Asn Gln Ile Val Thr Glu Pro Asp Ala Asn
                  65                  70                  75

 ttt ccc cag ttc ttg cat gag ggg tat gta cca tgc caa ggt ctt tac      290
 Phe Pro Gln Phe Leu His Glu Gly Tyr Val Pro Cys Gln Gly Leu Tyr
              80                  85                  90

 tcc cat atc aac cag acc ttg aag gag gct cac ttc aac agc ctg cag      338
 Ser His Ile Asn Gln Thr Leu Lys Glu Ala His Phe Asn Ser Leu Gln
          95                 100                 105

 cag cga ggg caa gct cca aca tga tgaattagga cttccttatt ccaacctaaa     392
 Gln Arg Gly Gln Ala Pro Thr 
     110                 115

 ctgtgtttat aaaagcaatt gcatacacac caaaaaaagt ctattggttt ttaagtctac    452

 attttaagta acaagttaat gggcagttgt ttaattgggg ttttacttca ctgttgtact    512

 tttaaagggg ctgtgaataa atgtttatga aattttaaaa aaaaaaaa                 560




      <210> 59
      <211> 1385
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(608)

      <400> 59
 aaggg    atg ggt gtt tgg gag gag gaa aag gct ctt gct gta ctc cta      47
          Met Gly Val Trp Glu Glu Glu Lys Ala Leu Ala Val Leu Leu
            1               5                  10

 gag gtt gga att aaa gtg gaa aag cca gaa aat tca agt cct tta cta       95
 Glu Val Gly Ile Lys Val Glu Lys Pro Glu Asn Ser Ser Pro Leu Leu
  15                  20                  25                  30

 aca tgt ctg gag att aga aga aag ctg aaa agg aga gga gaa gga gca      143
 Thr Cys Leu Glu Ile Arg Arg Lys Leu Lys Arg Arg Gly Glu Gly Ala
                  35                  40                  45

 aaa aga gat aaa aca gga agc agt cca tat aaa att gaa aat gcc atc      191
 Lys Arg Asp Lys Thr Gly Ser Ser Pro Tyr Lys Ile Glu Asn Ala Ile
              50                  55                  60

 ttg gaa gaa aac att gaa gaa gca ccc aag aag aaa aat cag agc aaa      239
 Leu Glu Glu Asn Ile Glu Glu Ala Pro Lys Lys Lys Asn Gln Ser Lys
          65                  70                  75

 ctg gta tta cat gaa acc ttt cct aaa cat aca ttt ctg atg aac ggc      287
 Leu Val Leu His Glu Thr Phe Pro Lys His Thr Phe Leu Met Asn Gly
      80                  85                  90

 tta att caa gga gta aag ggt ttg ttg tca ttc ctt agt gcc ccg ctt      335
 Leu Ile Gln Gly Val Lys Gly Leu Leu Ser Phe Leu Ser Ala Pro Leu
  95                 100                 105                 110

 att ggt gct ctt tct gat gtt tgg ggc cga aaa tcc ttc ttg ctg cta      383
 Ile Gly Ala Leu Ser Asp Val Trp Gly Arg Lys Ser Phe Leu Leu Leu
                 115                 120                 125

 acg gtg ttt ttc aca tgt gcc cca att cct tta atg aag atc agc cca      431
 Thr Val Phe Phe Thr Cys Ala Pro Ile Pro Leu Met Lys Ile Ser Pro
             130                 135                 140

 tgg tgg tac ttt gct gtt atc tct gtt tct ggg gtt ttt gca gtg act      479
 Trp Trp Tyr Phe Ala Val Ile Ser Val Ser Gly Val Phe Ala Val Thr
         145                 150                 155

 ttt tct gtg gta ttt gca tac gta gca gat ata acc caa gag cat gaa      527
 Phe Ser Val Val Phe Ala Tyr Val Ala Asp Ile Thr Gln Glu His Glu
     160                 165                 170

 aga agt atg gct tat gga ctg gta tgt atg ttt att cta tac ctt ttg      575
 Arg Ser Met Ala Tyr Gly Leu Val Cys Met Phe Ile Leu Tyr Leu Leu
 175                 180                 185                 190

 tat ctg ctg aga aat gcc ttc ttt tta aga taa atattatt ataaggagtg      626
 Tyr Leu Leu Arg Asn Ala Phe Phe Leu Arg 
                 195                 200

 caaacctttg cattacaaga tttttgcgta aaatatattt tgtaataaaa tcattcatta    686

 gactacattt aaaatttttt tgcggtatga ggctatgtaa gttttgattc ttttcattta    746

 gtagatattc ataagtcaca tgtcagaatt gaaattatag tatattttac cttgtagagt    806

 tctttttaac agaatcctaa aaataagaat tatttagtat gtcaagagtt aaaaaaaatc    866

 actactcatt taatgtctaa tctaaaatac aacaggctaa catctagctc agggatcagc    926

 aaaccttttt tgtggctttg tgggccacgt acagtctctg tctcattctt ttgtttttgc    986

 atgtgtattt atgtttataa actctttaaa aatgtaagaa acagccagat ttgagccata   1046

 gtggtaggtc gccaactcct ggacactgtt ttggtaaact aaattatggc agtataatgt   1106

 gtcatctatc aaatctagga attaaaggaa aaaagcctag taatagaatg actactatag   1166

 gcacaataat agatcactac tgaatagcca gaaataggac agtgatgcat ttcggtaaat   1226

 gtgagacaaa taccttgtga taaataagga ctgaatattg tgttgggctg aattagtttt   1286

 aaaagggact gatttctgat tcaaaggacg ttatagtgaa gaatcataag atttttgggg   1346

 aggaaacacc tatagagaga aagttagaaa aagaactaa                          1385




      <210> 60
      <211> 1556
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (317)..(1516)

      <400> 60
 gaagggagaa gctccggaaa tcccgggtag acgacctcgt gccgagcgag cgagggagag     60

 gcacagtcag agggaacgcc cgcgcgggga gccaggggcg cccgaccccg cgcgccgccg    120

 cagcggcgcg cagcccccga cgcgccctgt ggggacccgg accaggaggg accctgcccc    180

 gggaaaaggc tgtggagacc tgggctccga ccccagttca tccccccaca cccccgccgc    240

 cccgtgccac cctggtccgc gctgggaacc ctatcctgcc cctcgtgtca gcccggcact    300

 ggccagaatc gcgggc    atg gcg gtg acc atg ctg cag gac tgg tgc cgg     349
                      Met Ala Val Thr Met Leu Gln Asp Trp Cys Arg
                        1               5                  10

 tgg atg ggg gtc aac gct cgc agg ggc ctg ctc atc ctg ggc atc ccg      397
 Trp Met Gly Val Asn Ala Arg Arg Gly Leu Leu Ile Leu Gly Ile Pro
              15                  20                  25

 gag gac tgt gat gat gcc gaa ttc caa gag tcc ctc gag gct gcc ctg      445
 Glu Asp Cys Asp Asp Ala Glu Phe Gln Glu Ser Leu Glu Ala Ala Leu
          30                  35                  40

 agg cct atg gga cac ttt aca gtg cta ggc aaa gcg ttt cga gag gag      493
 Arg Pro Met Gly His Phe Thr Val Leu Gly Lys Ala Phe Arg Glu Glu
      45                  50                  55

 gat aat gcc acc gcg gcc ctg gtc gag ctc gac cgg gaa gtc aac tat      541
 Asp Asn Ala Thr Ala Ala Leu Val Glu Leu Asp Arg Glu Val Asn Tyr
  60                  65                  70                  75

 gct ttg gtc ccc agg gaa atc ccc ggc act ggg ggc ccg tgg aac gtg      589
 Ala Leu Val Pro Arg Glu Ile Pro Gly Thr Gly Gly Pro Trp Asn Val
                  80                  85                  90

 gtc ttt gtg ccc cgt tgc tca ggc gag gag ttt ctc ggt ctc ggt cgc      637
 Val Phe Val Pro Arg Cys Ser Gly Glu Glu Phe Leu Gly Leu Gly Arg
              95                 100                 105

 gtg ttc cac ttc ccg gag caa gag ggg cag atg gtg gag agc gtg gcc      685
 Val Phe His Phe Pro Glu Gln Glu Gly Gln Met Val Glu Ser Val Ala
         110                 115                 120

 ggc gcc ctg ggt gtg ggg ctg cgc agg gtg tgc tgg ctg cga tcc atc      733
 Gly Ala Leu Gly Val Gly Leu Arg Arg Val Cys Trp Leu Arg Ser Ile
     125                 130                 135

 ggt cag gcg gtc cag ccc tgg gtg gag gcc gtg agg tgc cag agc ctg      781
 Gly Gln Ala Val Gln Pro Trp Val Glu Ala Val Arg Cys Gln Ser Leu
 140                 145                 150                 155

 ggc gtg ttt tcc ggg agg gac cag cca gcc cca ggg gag gag tcc ttt      829
 Gly Val Phe Ser Gly Arg Asp Gln Pro Ala Pro Gly Glu Glu Ser Phe
                 160                 165                 170

 gag gtc tgg cta gac cac acc acc gaa atg ctg cat gtg tgg cag ggg      877
 Glu Val Trp Leu Asp His Thr Thr Glu Met Leu His Val Trp Gln Gly
             175                 180                 185

 gtc tcg gaa agg gag agg agg agg agg ctg ctg gaa ggc ttg cgt ggg      925
 Val Ser Glu Arg Glu Arg Arg Arg Arg Leu Leu Glu Gly Leu Arg Gly
         190                 195                 200

 acc gcc ctg cag ctc gtg cac gcg ctc ctg gcg gag aac ccc gcc agg      973
 Thr Ala Leu Gln Leu Val His Ala Leu Leu Ala Glu Asn Pro Ala Arg
     205                 210                 215

 acg gcg cag gac tgt ctg gcg gcc ctg gcc cag gtg ttt gga gac aac     1021
 Thr Ala Gln Asp Cys Leu Ala Ala Leu Ala Gln Val Phe Gly Asp Asn
 220                 225                 230                 235

 gag tcc cag gcg acc atc cgg gtg aag tgt ctg acc gct cag cag cag     1069
 Glu Ser Gln Ala Thr Ile Arg Val Lys Cys Leu Thr Ala Gln Gln Gln
                 240                 245                 250

 tca ggc gag cgt ctc tca gct ttc gtg ttg cgg ctg gaa gtg ctg ctg     1117
 Ser Gly Glu Arg Leu Ser Ala Phe Val Leu Arg Leu Glu Val Leu Leu
             255                 260                 265

 cag aag gcc atg gag aag gag gcc ctg gcc aga gca tcc gcc gac cgc     1165
 Gln Lys Ala Met Glu Lys Glu Ala Leu Ala Arg Ala Ser Ala Asp Arg
         270                 275                 280

 gtg cgc ctg agg cag atg ctc acc agg gcc cac ctt act gag cct ctg     1213
 Val Arg Leu Arg Gln Met Leu Thr Arg Ala His Leu Thr Glu Pro Leu
     285                 290                 295

 gat gaa gca ctg agg aag ctg aga atg gcc ggg agg tct cca agt ttc     1261
 Asp Glu Ala Leu Arg Lys Leu Arg Met Ala Gly Arg Ser Pro Ser Phe
 300                 305                 310                 315

 ttg gag atg ctg ggg ctc gtt cgg gag tct gag gca tgg gag gcc agt     1309
 Leu Glu Met Leu Gly Leu Val Arg Glu Ser Glu Ala Trp Glu Ala Ser
                 320                 325                 330

 cta gcc agg agc gtg aga gcc cag aca cag gaa ggg gcc ggt gcc cgg     1357
 Leu Ala Arg Ser Val Arg Ala Gln Thr Gln Glu Gly Ala Gly Ala Arg
             335                 340                 345

 gct ggt gcc cag gct gtt gcc aga gcc agc act aaa gta gag gcg gtc     1405
 Ala Gly Ala Gln Ala Val Ala Arg Ala Ser Thr Lys Val Glu Ala Val
         350                 355                 360

 cca gga ggt cct ggt cgg gag cca gag ggc ctc ctc cag gca gga ggc     1453
 Pro Gly Gly Pro Gly Arg Glu Pro Glu Gly Leu Leu Gln Ala Gly Gly
     365                 370                 375

 cag gag gct gag gag ctc ctc cag gag ggg ctc aag ccc gtc ctg gag     1501
 Gln Glu Ala Glu Glu Leu Leu Gln Glu Gly Leu Lys Pro Val Leu Glu
 380                 385                 390                 395

 gaa tgt gat aac tag gttggggctg gggaggcagc ccagcgcgag tcctccccgg     1556
 Glu Cys Asp Asn 






      <210> 61
      <211> 2315
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (248)..(856)

      <400> 61
 acgtgcactg atatttttat gtacatttat ataaatatat atatacatat atattcgctt     60

 gaagaatcac caagcaaatt ggggagaggg tcttttccaa tagaacttac acctccattt    120

 gttgtgacgt cttgcacttc ccaatgctga gcgcctctat ggctccaatg aactggtgta    180

 ttttgcagca aatctgatga cttgtatgga aatggcatga aagttaccca gattacatct    240

 ggtgcaa  atg cac tcg gag cct ggg gcc aga ctg gtg cta aca ctg caa     289
          Met His Ser Glu Pro Gly Ala Arg Leu Val Leu Thr Leu Gln
            1               5                  10

 acc ttg tcc aga gct ctc tcc aac ctg aag gct tgc tgg ggg tgc aat      337
 Thr Leu Ser Arg Ala Leu Ser Asn Leu Lys Ala Cys Trp Gly Cys Asn
  15                  20                  25                  30

 gtc acc ttc aca cat gct ggg ccc ttt cag aaa agt gcc aga tcg tgt      385
 Val Thr Phe Thr His Ala Gly Pro Phe Gln Lys Ser Ala Arg Ser Cys
                  35                  40                  45

 aac tgg tgc tat ttt tca tgc tct ggt aca atg tgt agc acc acg ggg      433
 Asn Trp Cys Tyr Phe Ser Cys Ser Gly Thr Met Cys Ser Thr Thr Gly
              50                  55                  60

 gtc tca gct tta cca aaa tca aaa ttc cat ttg tca gct aag tgc aga      481
 Val Ser Ala Leu Pro Lys Ser Lys Phe His Leu Ser Ala Lys Cys Arg
          65                  70                  75

 ggc att tgt ttt ttg ctc tcc tcc cac aga att gtc ggc cat tta ttt      529
 Gly Ile Cys Phe Leu Leu Ser Ser His Arg Ile Val Gly His Leu Phe
      80                  85                  90

 gca ggc ctt ttg cgg gat ttc ttg gct att tat ttg cag gcc ttt ttt      577
 Ala Gly Leu Leu Arg Asp Phe Leu Ala Ile Tyr Leu Gln Ala Phe Phe
  95                 100                 105                 110

 ccc agc ccc aaa ttc ttg ggt tgg ctc tgt ctg ctt aaa gag cct gtc      625
 Pro Ser Pro Lys Phe Leu Gly Trp Leu Cys Leu Leu Lys Glu Pro Val
                 115                 120                 125

 ttc aca aag ctg cac tcg ggt gcc tct gtg cgc tgt ctt aga tcc tac      673
 Phe Thr Lys Leu His Ser Gly Ala Ser Val Arg Cys Leu Arg Ser Tyr
             130                 135                 140

 tgc cgg ccc ttc agg act ccg agc cag gaa aga act ctc caa cct ctg      721
 Cys Arg Pro Phe Arg Thr Pro Ser Gln Glu Arg Thr Leu Gln Pro Leu
         145                 150                 155

 gct cga gac tct act ttt ttt ctc att ctt ttc ctt act ctc ctc ctc      769
 Ala Arg Asp Ser Thr Phe Phe Leu Ile Leu Phe Leu Thr Leu Leu Leu
     160                 165                 170

 ctt cta ctt ccg act aat tcc atc tct ttt ttt ttt ttg ttc ctc tcc      817
 Leu Leu Leu Pro Thr Asn Ser Ile Ser Phe Phe Phe Leu Phe Leu Ser
 175                 180                 185                 190

 ttt tcc tat tcc tcc ttc cca cca tct ctg agt tgt tga ctttctccta       866
 Phe Ser Tyr Ser Ser Phe Pro Pro Ser Leu Ser Cys 
                 195                 200

 taatccttct ctattccctt tctctttttg tccacctctc ctttagtctc tgtttctctg    926

 cccttcttat tcctcttctg tcctttctcc tctcctcaaa tctctgatca tcttctcccg    986

 tacatccctg tattgatttt tctgtcctct aaagggctca tggctgattc agacagcaag   1046

 tccatgcact ggactaatga cacaaatact ttaggtcgcc gtttcaccta ctcagcccag   1106

 aaagtaaagc tgagcgtgag gccctgacct ggagcctgct ccagcccgcc tcccggagcc   1166

 agcctgcacc gttgccctgg cagcgatgat gcatgtgctg tgggccctgc cggcgcctga   1226

 gtgcctctgc ctgaacactg ctcctaagcg agcccactcc cagcactacc gcatggctct   1286

 gaggacattt tctttcaata aaggcagact ctggccccaa ttattctgat agcaaacctc   1346

 ttcctcctca ttgaagccat gccatcacct tggtttggag agagacattt ttttcccatt   1406

 cataagcttt ctttttccca tttttatgtg aagccccctc tgcttttcag ctggtgattg   1466

 ctctggtgag actgaatgga cttgctggtg aaatgaaatc tcttctttcc tgtcttggtc   1526

 ctgcctaaat tcctacaaat atatttaagc caaggactca ggctaattcc taagttgatc   1586

 acattaattt gttactccta gagggaaaaa gatcaattcc cttgaagcat gtggagtacc   1646

 tcctgtgaca gctgacttgc caggggactc cctacagaat tctgtgatat acattttact   1706

 tctgtgtatg tatggtatat atggtatgta taccatgtac acacgttaca ttgagtatga   1766

 atgactgtgg ttggaaacac acacacacac tcaagtctgt aaatatcctt cctcactgaa   1826

 acctgtgctt tggaaatcat ttcttgtaca gctgtgcagt ttcttgtaac agctgaggac   1886

 aaagctaaga caggcggaca atttagacaa agatcatcta aagagtatag tatctcccta   1946

 gcaactcatg aggacagaca accaagtggc aaggttgact cccaatggga tggcagactt   2006

 ttcttctctc ctttttgagt ttgtgtttcc taagtgtttc ttaacttctg agtgcaccag   2066

 gctgtacccg ttagatcctt tcaatatgac agttttgtgc ttctctctga caggatgttt   2126

 ctccaccgag ctgtagcaca ggatgggagg gaggtgggaa tactccttgc ctaggctgga   2186

 gtttacagag acactgcaca gcttacactc ctgttaagtg taaatattca acacttccat   2246

 tccatttgtg taaaaaataa agcacacacg attataaaat caagatgtat atttcataaa   2306

 aaaaaaaaa                                                           2315




      <210> 62
      <211> 995
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (141)..(944)

      <400> 62
 cgacaagcaa ttcggcacga ggggcaagcg aactaggcca aactacttgc acgttccctc     60

 gagaagatct ttggagtaga cacaaaagcc gcgctggcga tgccgacaaa aagcgccggc    120

 aattggggtc gcagctggag    atg ctg cgg ccg gca ggg ctc tgg cgc tta     170
                          Met Leu Arg Pro Ala Gly Leu Trp Arg Leu
                            1               5                  10

 tgt cgg cga cct tgg gcg gcg agg gtc cca gcg gag aat ctt ggc cgt      218
 Cys Arg Arg Pro Trp Ala Ala Arg Val Pro Ala Glu Asn Leu Gly Arg
                  15                  20                  25

 agg gaa gtc acc tct ggt gtc tct ccc cgc ggt agc acc tcg ccc aga      266
 Arg Glu Val Thr Ser Gly Val Ser Pro Arg Gly Ser Thr Ser Pro Arg
              30                  35                  40

 acc ctg aat att ttc gac cgg gat ttg aaa agg aaa cag aag aac tgg      314
 Thr Leu Asn Ile Phe Asp Arg Asp Leu Lys Arg Lys Gln Lys Asn Trp
          45                  50                  55

 gca gcc cgg cag ccc gag ccg acc aaa ttt gac tac ctg aag gag gag      362
 Ala Ala Arg Gln Pro Glu Pro Thr Lys Phe Asp Tyr Leu Lys Glu Glu
      60                  65                  70

 gtt gga agt cgg atc gca gac cgt gta tat gac ata ccc aga aat ttc      410
 Val Gly Ser Arg Ile Ala Asp Arg Val Tyr Asp Ile Pro Arg Asn Phe
  75                  80                  85                  90

 ccc ctt gct ttg gat ctt ggt tgt gga aga ggt tac att gca caa tat      458
 Pro Leu Ala Leu Asp Leu Gly Cys Gly Arg Gly Tyr Ile Ala Gln Tyr
                  95                 100                 105

 ttg aat aag gaa act att gga aag ttt ttc caa gct gac att gca gaa      506
 Leu Asn Lys Glu Thr Ile Gly Lys Phe Phe Gln Ala Asp Ile Ala Glu
             110                 115                 120

 aat gct ttg aaa aat tcc tca gaa aca gaa ata cct act gtc agc gtt      554
 Asn Ala Leu Lys Asn Ser Ser Glu Thr Glu Ile Pro Thr Val Ser Val
         125                 130                 135

 tta gct gat gaa gaa ttc ctt ccc ttc aaa gaa aat aca ttt gac ctg      602
 Leu Ala Asp Glu Glu Phe Leu Pro Phe Lys Glu Asn Thr Phe Asp Leu
     140                 145                 150

 gtg gtt agc agt tta agt ttg cat tgg gtg aat gac ctt cct aga gca      650
 Val Val Ser Ser Leu Ser Leu His Trp Val Asn Asp Leu Pro Arg Ala
 155                 160                 165                 170

 ctt gag cag att cat tat att tta aaa cca gat gga gtg ttt atc ggt      698
 Leu Glu Gln Ile His Tyr Ile Leu Lys Pro Asp Gly Val Phe Ile Gly
                 175                 180                 185

 gca atg ttt gga ggc gac aca ctc tat gaa ctt cgg tgt tcc tta cag      746
 Ala Met Phe Gly Gly Asp Thr Leu Tyr Glu Leu Arg Cys Ser Leu Gln
             190                 195                 200

 tta gcg gaa acg gaa agg gaa gga gga ttt tct cca cac att tct cct      794
 Leu Ala Glu Thr Glu Arg Glu Gly Gly Phe Ser Pro His Ile Ser Pro
         205                 210                 215

 ttc act gct gtc aat gac ctg gga cat ctg ctt ggg aga gct ggc ttt      842
 Phe Thr Ala Val Asn Asp Leu Gly His Leu Leu Gly Arg Ala Gly Phe
     220                 225                 230

 aat act ctg act gtg gac act gat gaa att caa gtt aac tat cct gga      890
 Asn Thr Leu Thr Val Asp Thr Asp Glu Ile Gln Val Asn Tyr Pro Gly
 235                 240                 245                 250

 atg ttt gaa ttg atg gaa gat tta caa gaa caa aag tcc aga atg ttg      938
 Met Phe Glu Leu Met Glu Asp Leu Gln Glu Gln Lys Ser Arg Met Leu
                 255                 260                 265

 acc taa ttttacaaaa caagctgcat atcagctgat gaatgcatga gaaattttca       994
 Thr 


 a                                                                    995




      <210> 63
      <211> 1200
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (141)..(533)

      <400> 63
 cgacaagcaa ttcggcacga ggggcaagcg aactaggcca aactacttgc acgttccctc     60

 gagaagatct ttggagtaga cacaaaagcc gcgctggcga tgccgacaaa aagcgccggc    120

 aattggggtc gcagctggag    atg ctg cgg ccg gca ggg ctc tgg cgc tta     170
                          Met Leu Arg Pro Ala Gly Leu Trp Arg Leu
                            1               5                  10

 tgt cgg cga cct tgg gcg gcg agg gtc cca gcg gag aat ctt ggc cgt      218
 Cys Arg Arg Pro Trp Ala Ala Arg Val Pro Ala Glu Asn Leu Gly Arg
                  15                  20                  25

 agg gaa gtc acc tct ggt gtc tct ccc cgc ggt agc acc tcg ccc aga      266
 Arg Glu Val Thr Ser Gly Val Ser Pro Arg Gly Ser Thr Ser Pro Arg
              30                  35                  40

 acc ctg aat att ttc gac cgg gat ttg aaa agg aaa cag aag aac tgg      314
 Thr Leu Asn Ile Phe Asp Arg Asp Leu Lys Arg Lys Gln Lys Asn Trp
          45                  50                  55

 gca gcc cgg cag ccc gag ccg acc aaa ttt gac tac ctg aag gag gag      362
 Ala Ala Arg Gln Pro Glu Pro Thr Lys Phe Asp Tyr Leu Lys Glu Glu
      60                  65                  70

 gtt gga agt cgg atc gca gac cgt gta tat gac ata ccc aga aat ttc      410
 Val Gly Ser Arg Ile Ala Asp Arg Val Tyr Asp Ile Pro Arg Asn Phe
  75                  80                  85                  90

 ccc ctt gct ttg gat ctt ggt tgt gga aga ggt tac att gca caa tat      458
 Pro Leu Ala Leu Asp Leu Gly Cys Gly Arg Gly Tyr Ile Ala Gln Tyr
                  95                 100                 105

 ttg aat aag gaa act att gga aag ttt ttc caa gct gac att gca gaa      506
 Leu Asn Lys Glu Thr Ile Gly Lys Phe Phe Gln Ala Asp Ile Ala Glu
             110                 115                 120

 aat gct ttg ttt gca ttg ggt gaa tga ccttc ctagagcact tgagcagatt      558
 Asn Ala Leu Phe Ala Leu Gly Glu 
         125                 130

 cattatattt taaaaccaga tggagtgttt atcggtgcaa tgtttggagg cgacacactc    618

 tatgaacttc ggtgttcctt acagttagcg gaaacggaaa gggaaggagg attttctcca    678

 cacatttctc ctttcactgc tgtcaatgac ctgggacatc tgcttgggag agctggcttt    738

 aatactctga ctgtggacac tgatgaaatt caagttaact atcctggaat gtttgaattg    798

 atggaagatt tacaagaaca aaagtccaga atgttgacct aattttacaa aacaagctgc    858

 atatcagctg atgaatgcat gagaaatttt caaggctttc acagtggtct taaggtatgg    918

 gtgagagtaa ctgtgcttgg aatagaaaag ccctgctgca tcgagacaca atgctggcag    978

 ctgcggcagt gtacagagaa atgtacagaa atgaagatgg ttcagtacct gctacatacc   1038

 agatctatta catgatagga tggaaatatc atgagtcaca ggcaagacca gctgaaagag   1098

 gttccgcaac tgtgtcattt ggagagctag gaaaaataaa caaccttatg ccaccgggga   1158

 aaaaatcaca ataaatattt attcagtgtt aaaaaaaaaa aa                      1200




      <210> 64
      <211> 699
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (221)..(616)

      <400> 64
 gattcatgat aagaaccagt acccgatttc tgagctctgt aaacagttcc gtttgccctt     60

 caatgtgaag gtgtctgtca gggatctttc cattgaagag gacgtgttgg ctgccacacc    120

 aggactgcag ttggaggagg acattacaga ctcttaccta ctcataagtg actttgccaa    180

 ccccacggag tgctgggaaa ttcctgtggg ccgcttgaat  atg act gtt cag tta     235
                                              Met Thr Val Gln Leu
                                                1               5

 gtt agt aat ttc tct agg gat gca gaa cca ttt cta gtc agg act ctg      283
 Val Ser Asn Phe Ser Arg Asp Ala Glu Pro Phe Leu Val Arg Thr Leu
                  10                  15                  20

 gta gaa gag atc act gaa gag caa tat tac atg atg cgg aga tat gaa      331
 Val Glu Glu Ile Thr Glu Glu Gln Tyr Tyr Met Met Arg Arg Tyr Glu
              25                  30                  35

 agc tca gcc tca cat ccc cca cct cgc cct ccg aaa cac ccc tca gta      379
 Ser Ser Ala Ser His Pro Pro Pro Arg Pro Pro Lys His Pro Ser Val
          40                  45                  50

 gag gaa aca aag tta acc ctg cta acc tta gca gaa gaa agg acg gta      427
 Glu Glu Thr Lys Leu Thr Leu Leu Thr Leu Ala Glu Glu Arg Thr Val
      55                  60                  65

 gac ctg ccc aag tct ccc aag cgt cat cac gta gac ata acc aag aaa      475
 Asp Leu Pro Lys Ser Pro Lys Arg His His Val Asp Ile Thr Lys Lys
  70                  75                  80                  85

 ctt cac cca aat caa gct ggc ctg gat tca aaa gta ctg att ggt agt      523
 Leu His Pro Asn Gln Ala Gly Leu Asp Ser Lys Val Leu Ile Gly Ser
                  90                  95                 100

 cag aat gat ttg gtg gat gaa gag aaa gaa agg agc aac cgt ggg gcc      571
 Gln Asn Asp Leu Val Asp Glu Glu Lys Glu Arg Ser Asn Arg Gly Ala
             105                 110                 115

 aca gca ata gca gaa aca ttc aaa aat gaa aaa cat caa aaa taa caa      619
 Thr Ala Ile Ala Glu Thr Phe Lys Asn Glu Lys His Gln Lys 
         120                 125                 130

 gatgtgacag aagccactta ggcagcaaac ataaatgttg cagtgaaaaa agaagctagc    679

 cttctagctg acaaacgagg                                                699




      <210> 65
      <211> 906
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(594)

      <400> 65
  atg gag cag cag tcg gag gac gcg gaa ggc ctg cga gag tcg ccc gcg      48
  Met Glu Gln Gln Ser Glu Asp Ala Glu Gly Leu Arg Glu Ser Pro Ala
    1               5                  10                  15

 gcc cag tgc cgg cct tcg gtg cgg gct ggc agt gcg ggc aga gcc cgg       96
 Ala Gln Cys Arg Pro Ser Val Arg Ala Gly Ser Ala Gly Arg Ala Arg
              20                  25                  30

 ctg aga ggg gcg gcc ctg gag gag acg gag gcg gcg ggt ggg ccc gag      144
 Leu Arg Gly Ala Ala Leu Glu Glu Thr Glu Ala Ala Gly Gly Pro Glu
          35                  40                  45

 gcg caa gag gaa gat gag gac gaa gaa gag gcg ctg ccg cac tcc gag      192
 Ala Gln Glu Glu Asp Glu Asp Glu Glu Glu Ala Leu Pro His Ser Glu
      50                  55                  60

 gcc atg gac gtg ttc cag gag ggt ctg gct atg gtg gtg cag gac ccg      240
 Ala Met Asp Val Phe Gln Glu Gly Leu Ala Met Val Val Gln Asp Pro
  65                  70                  75                  80

 ctg ctc tgc gat ctg ccg atc cag gtt act ctg gaa gaa gtc aac tcc      288
 Leu Leu Cys Asp Leu Pro Ile Gln Val Thr Leu Glu Glu Val Asn Ser
                  85                  90                  95

 caa ata gcc cta gaa tac ggc cag gca atg acg gtc cga gtg tgc aag      336
 Gln Ile Ala Leu Glu Tyr Gly Gln Ala Met Thr Val Arg Val Cys Lys
             100                 105                 110

 atg gat gga gaa gta atg ccc gtg gtt gta gtg cag agt gcc aca gtc      384
 Met Asp Gly Glu Val Met Pro Val Val Val Val Gln Ser Ala Thr Val
         115                 120                 125

 ctg gac ctg aag aag gcc atc cag aga tac gtg cag ctc aag cag gag      432
 Leu Asp Leu Lys Lys Ala Ile Gln Arg Tyr Val Gln Leu Lys Gln Glu
     130                 135                 140

 cgt gaa ggg ggc att cag cac atc agc tgg tcc tac gtg tgg agg acg      480
 Arg Glu Gly Gly Ile Gln His Ile Ser Trp Ser Tyr Val Trp Arg Thr
 145                 150                 155                 160

 tac cat ctg acc tct gca gga gag aaa ctc acg gaa gac aga aag aag      528
 Tyr His Leu Thr Ser Ala Gly Glu Lys Leu Thr Glu Asp Arg Lys Lys
                 165                 170                 175

 ctc cga gac tac ggc atc cgg aat cga gac gag gtt tcc ttc atc aaa      576
 Leu Arg Asp Tyr Gly Ile Arg Asn Arg Asp Glu Val Ser Phe Ile Lys
             180                 185                 190

 aag ctg agg caa aag tga gcctcc agacaggaca accctcttca tcactggtgg      630
 Lys Leu Arg Gln Lys 
         195

 ctgagctttt tcccagcagg aatgggtcct cgaatcatcg tgcctctttc acagaaagga    690

 cgttgtggtg gcctcacccc aggcatgccc aacaggaact gtcagcataa acctgggggc    750

 cctcaggact aggacagggt gagccagtgc tccctccttt catgtacttg gcctgagact    810

 gacctctccc taggtccaaa tgccctagtc acatggcaga cccacggcct ggcccactgt    870

 ataaaataaa cctgtttgct tcttaaaaaa aaaaaa                              906




      <210> 66
      <211> 1160
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (714)..(1142)

      <400> 66
 gtccaggccg aggccgacag cacaagtgag gggctggagg acgctgtcca cagccgtggt     60

 gccagacccc ctgcagcagg cccaggtggg gatgaggacg aggacgagga ggacacggcc    120

 ccagagtccg cactggacac atccctggac aagtccttct ccgaggatgc ggtgaccgac    180

 tcctcggggt cgggcacact ccccagggcc cggggccggg cctcaaaggg gaccgggaag    240

 cgaaggaaga agcgtccctc caggagccag gaagaggttc cccctgattc tgatgataat    300

 aaaacaaaga aactgtgtgt gatccagtaa ggcctcaggc ccaggcccaa ggccaagtga    360

 gagagcccag gccacaggac atgctgccat tctgccaaga gaggctcttc tgggggccag    420

 gctgggactg ggccccggaa accaaaactc cgtgccttac ccagccgggg ccctcctgga    480

 gccttcttgg ggtgttgtgg ctgggaaccc gacaggcacc agtgccctgc caggcctggt    540

 gccctcctgg accgcctgca cgtgccagcc tcccacctgc ttcctaaagg caaccctggc    600

 ccacacccgc atgcgcccgg tgcagcctgc caagggccag tcggggggtg ctgcgtcctg    660

 ccagtgtcca ccacagctct gcctgccctt cagcccagca aggtttaatc aaa   atg     716
                                                              Met
                                                                1

 caa tgc ttt gca agt ctt tac tgc ttg gag gtg gct gag ttg ggg gcc      764
 Gln Cys Phe Ala Ser Leu Tyr Cys Leu Glu Val Ala Glu Leu Gly Ala
               5                  10                  15

 ctg ggc agg ggt aag ctg gca ggc agt gcc atg gca ggc cag ggt ccc      812
 Leu Gly Arg Gly Lys Leu Ala Gly Ser Ala Met Ala Gly Gln Gly Pro
          20                  25                  30

 ctc cca tgg ggt ctg gcc ccc gtt cca gca tgt cca gcc cct gaa gtt      860
 Leu Pro Trp Gly Leu Ala Pro Val Pro Ala Cys Pro Ala Pro Glu Val
      35                  40                  45

 gga gtt ggg ggc ggt ctg cct ttg ctg cca ctg cca ggc ctc tgc cct      908
 Gly Val Gly Gly Gly Leu Pro Leu Leu Pro Leu Pro Gly Leu Cys Pro
  50                  55                  60                  65

 gca gct gaa act tgg cca tca cat caa cag aaa acc cct ccc agt gcc      956
 Ala Ala Glu Thr Trp Pro Ser His Gln Gln Lys Thr Pro Pro Ser Ala
                  70                  75                  80

 agc tgc cca gcg tgg gca ggc cct ggg gac aat aca ggt cca cct gag     1004
 Ser Cys Pro Ala Trp Ala Gly Pro Gly Asp Asn Thr Gly Pro Pro Glu
              85                  90                  95

 ggg ctg cag ggt gac acc cag cag ccg ctg ccc cct cac tgc cca ccc     1052
 Gly Leu Gln Gly Asp Thr Gln Gln Pro Leu Pro Pro His Cys Pro Pro
         100                 105                 110

 agc gag ggc agc cta ccc gag cct gcc ccc tgc cag gtg tgt gcc ctg     1100
 Ser Glu Gly Ser Leu Pro Glu Pro Ala Pro Cys Gln Val Cys Ala Leu
     115                 120                 125

 agg ctg gcg gct gga tgc gtg gcc aat aaa aag cag acc tag cccggaa     1149
 Arg Leu Ala Ala Gly Cys Val Ala Asn Lys Lys Gln Thr 
 130                 135                 140

 aaaaaaaaaa a                                                        1160




      <210> 67
      <211> 1437
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (158)..(931)

      <400> 67
 cgctgtcgac gatttcgttt taacaggacc ctcccggagg ttgaagcagc agcagctgca     60

 gcggcagcag cggcagcaga ggcagcagca gtagccacca ctccgccgag gccgcaaccc    120

 cggctcggcc tccccaggcc ccgccgctgc cgcagtc atg gct gct gat ggg gtg     175
                                          Met Ala Ala Asp Gly Val
                                            1               5

 gac gaa cgc tcg cct ctg ctg tca gca tcc cac tcc gga aat gtc act      223
 Asp Glu Arg Ser Pro Leu Leu Ser Ala Ser His Ser Gly Asn Val Thr
              10                  15                  20

 ccc acc gcc cca ccg tac ttg caa gaa agc agc ccc aga gcg gag ctc      271
 Pro Thr Ala Pro Pro Tyr Leu Gln Glu Ser Ser Pro Arg Ala Glu Leu
          25                  30                  35

 cca cct cca tat aca gcc att gcc agt cca gac gcc agt ggt att cca      319
 Pro Pro Pro Tyr Thr Ala Ile Ala Ser Pro Asp Ala Ser Gly Ile Pro
      40                  45                  50

 gta ata aac tgc cgt gtg tgc caa tca cta atc aat ttg gat ggc aag      367
 Val Ile Asn Cys Arg Val Cys Gln Ser Leu Ile Asn Leu Asp Gly Lys
  55                  60                  65                  70

 ctt cac cag cat gtg gtt aag tgc aca gtt tgc aat gaa gct acg cca      415
 Leu His Gln His Val Val Lys Cys Thr Val Cys Asn Glu Ala Thr Pro
                  75                  80                  85

 atc aaa aac ccc cca aca ggc aag aaa tat gtt aga tgc cct tgt aat      463
 Ile Lys Asn Pro Pro Thr Gly Lys Lys Tyr Val Arg Cys Pro Cys Asn
              90                  95                 100

 tgt ctt ctc att tgt aag gac aca tct cgg cga ata gga tgc cca aga      511
 Cys Leu Leu Ile Cys Lys Asp Thr Ser Arg Arg Ile Gly Cys Pro Arg
         105                 110                 115

 ccc aac tgt aga cgg ata att aac ctt ggc cca gta atg ctt att tct      559
 Pro Asn Cys Arg Arg Ile Ile Asn Leu Gly Pro Val Met Leu Ile Ser
     120                 125                 130

 gaa gaa caa cca gct cag cct gca ttg cca atc caa cca gaa ggt aca      607
 Glu Glu Gln Pro Ala Gln Pro Ala Leu Pro Ile Gln Pro Glu Gly Thr
 135                 140                 145                 150

 agg gtc gtg tgt ggg cac tgt gga aac aca ttc ctg tgg atg gaa ctg      655
 Arg Val Val Cys Gly His Cys Gly Asn Thr Phe Leu Trp Met Glu Leu
                 155                 160                 165

 agg ttc aac act ctg gca aaa tgc cca cac tgc aaa aaa atc tcc tca      703
 Arg Phe Asn Thr Leu Ala Lys Cys Pro His Cys Lys Lys Ile Ser Ser
             170                 175                 180

 gtg ggt agt gca ctt cca cga aga cgc tgc tgt gca tat att acc att      751
 Val Gly Ser Ala Leu Pro Arg Arg Arg Cys Cys Ala Tyr Ile Thr Ile
         185                 190                 195

 gga atg ata tgt att ttc att gga gtt ggg tta act gtt ggc acc cca      799
 Gly Met Ile Cys Ile Phe Ile Gly Val Gly Leu Thr Val Gly Thr Pro
     200                 205                 210

 gat ttt gca agg cga ttt cga gca acc tat gtt tct tgg gca att gct      847
 Asp Phe Ala Arg Arg Phe Arg Ala Thr Tyr Val Ser Trp Ala Ile Ala
 215                 220                 225                 230

 tat ctc cta gga ttg atc tgc ctt atc cga gct tgt tat tgg gga gcc      895
 Tyr Leu Leu Gly Leu Ile Cys Leu Ile Arg Ala Cys Tyr Trp Gly Ala
                 235                 240                 245

 ata aga gtc agt tat cca gaa cac agt ttt gca taa gctt gtttatgatt      945
 Ile Arg Val Ser Tyr Pro Glu His Ser Phe Ala 
             250                 255

 cagtaatgca ggtgagagtg tctagcagtt cttggtaagc tactctggac atctttaaat   1005

 tatttatcct aatggattcc attctggttt atgtataatc gtttcaagac tttgggagtc   1065

 ttttatgaac aaatgctcat tgcactatat tatatgcaaa ttgttttgct gctaggtttt   1125

 caaaatttga ataataaagc cttttcatgt tcttttacat ctcttataga tatttttgga   1185

 tttgttacca aacattacat ttactctcac ccttttatta tttttaaata agttatttca   1245

 ttacttgctg atacatgagt attcctaagt gtttataaat atttctataa tagtttcaca   1305

 tttatattta cattttaatt aaacagtatc aaaattgctt gcttaaaacc taagcaatat   1365

 gcattttgct tgaactgctt actgtaactt taacctaaga ttatagtgac cttattcagg   1425

 aaaaaaaaaa aa                                                       1437




      <210> 68
      <211> 641
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(474)

      <400> 68
 ccggaagtgc tcacacgtgt gctccctgcc ctgctcctgg ccccttggct ggccgggctg     60

 tttctggcc    atg ggt cgc tcc cgc cgg aca ggc gcg cac cga gcg cac     108
              Met Gly Arg Ser Arg Arg Thr Gly Ala His Arg Ala His
                1               5                  10

 tct cta gcc cgg cag atg aag gcg aag cgg cgg cgg ccg gac ttg gat      156
 Ser Leu Ala Arg Gln Met Lys Ala Lys Arg Arg Arg Pro Asp Leu Asp
      15                  20                  25

 gag att cac cgc gag ctg cgg cct cag gga tcc gca cga ccc cag ccc      204
 Glu Ile His Arg Glu Leu Arg Pro Gln Gly Ser Ala Arg Pro Gln Pro
  30                  35                  40                  45

 gac cca aac gcc gag ttc gac ccc gac ctg cca ggg ggc ggt ctg cac      252
 Asp Pro Asn Ala Glu Phe Asp Pro Asp Leu Pro Gly Gly Gly Leu His
                  50                  55                  60

 cgc tgt ctg gcc tgc gcg agg tac ttc atc gat tcc acc aac ctg aag      300
 Arg Cys Leu Ala Cys Ala Arg Tyr Phe Ile Asp Ser Thr Asn Leu Lys
              65                  70                  75

 acc cac ttc cga tcc aaa gac cac aag aaa agg ctg aag cag ctg agc      348
 Thr His Phe Arg Ser Lys Asp His Lys Lys Arg Leu Lys Gln Leu Ser
          80                  85                  90

 gtc gag ccc tac agt cag gaa gag gcg gag agg gca gcg ggt atg gga      396
 Val Glu Pro Tyr Ser Gln Glu Glu Ala Glu Arg Ala Ala Gly Met Gly
      95                 100                 105

 tcc tat gtg ccc ccc agg cgg ctg gca gtg ccc acg gaa gtg tcc act      444
 Ser Tyr Val Pro Pro Arg Arg Leu Ala Val Pro Thr Glu Val Ser Thr
 110                 115                 120                 125

 gag gtc cct gag atg gat acc tct acc tga c atggcctgaa gatgcagggc      495
 Glu Val Pro Glu Met Asp Thr Ser Thr 
                 130

 agaggaattg cccatggaca gtgacgcaag gactaggctg ggagggagcg tgccaacccc    555

 ttttgcctct gggtttgggg agcggagggc ctcttcttgg tgccctgccc ccaataaagg    615

 aactggacaa agagaaaaaa aaaaaa                                         641




      <210> 69
      <211> 1739
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (919)..(1674)

      <400> 69
 ggacagcacg cgctaacaac ttcacgtagg attctaataa aatcttgcac cacagggcta     60

 tagaaaggaa gaaagttttg aaatgcagag gaacacttct gtttgctcaa ctggccttcc    120

 tgtagctccc tgagccaccg tctcctttgt taatgcctga aaaatattag aaagaaagtt    180

 cacataaaat atcctttaag attattcaag tggaaatcat cttgggttaa atcagtcctt    240

 ttagtttcct ctttgtcgca acccctcgcc gccgccgccg ggtcgcgaca aggaggagga    300

 ggaggaggtg gccggtggag actgcatagg gagcacggtc tacagcaaac actggctctt    360

 cggcgtcctc agcggactca tccagattgt tagccctgaa aacaccaaat ctagctcaga    420

 tgatgaggag cagctgacgg agcttgatga agaaatggag aatgaaattt gcagagtatg    480

 ggatatgtca atggatgagg acgtggcttt atttctccaa gaatttaatg ctcctgatat    540

 attcatggga gtactggcca agtccaagtg tcctcgatta agagaaatct gtgtgggaat    600

 tttaggtaat atggcctgtt tccaggagat atgtgtgtcc atcagcagtg ataaaaatct    660

 tgggcaggtg ttattgcact gtttgtatga ttcagaccca cctactctgc tggaaacaag    720

 caggtgttgc ttacttgcct ttcccaggca gaagtggcca gtgttgggtt gaaaggatcc    780

 aggaacatcc agctatttat gatagcattt gcttcattat gtcaagttca acaaatgttg    840

 acttgctggt gaaggtgggg gaggttgtgg acaagctctt tgatttggat gagaaactaa    900

 tgttagaatg ggtcagaa  atg ggg ctg ctc agc ctc tgg gac caa ccc cag     951
                      Met Gly Leu Leu Ser Leu Trp Asp Gln Pro Gln
                        1               5                  10

 gaa gag tct gaa gag cag cca gtg ttt cgg ctt gtg ccc tgt ata ctt      999
 Glu Glu Ser Glu Glu Gln Pro Val Phe Arg Leu Val Pro Cys Ile Leu
              15                  20                  25

 gaa gct gcc aaa caa gta cgt tct gaa aat cca gaa tgg ctt gat gtt     1047
 Glu Ala Ala Lys Gln Val Arg Ser Glu Asn Pro Glu Trp Leu Asp Val
          30                  35                  40

 tac atg cac att tta caa ctg ctt act aca gtg gat gat gga att caa     1095
 Tyr Met His Ile Leu Gln Leu Leu Thr Thr Val Asp Asp Gly Ile Gln
      45                  50                  55

 gca att gta cat tgt cct gac act gga aaa gac att tgg aat tta ctt     1143
 Ala Ile Val His Cys Pro Asp Thr Gly Lys Asp Ile Trp Asn Leu Leu
  60                  65                  70                  75

 ttt gac ctg gtc tgc cat gaa ttc tgc cag tct gat gat cca ccc atc     1191
 Phe Asp Leu Val Cys His Glu Phe Cys Gln Ser Asp Asp Pro Pro Ile
                  80                  85                  90

 att ctt caa gaa cag aaa aca gtg cta gcc tct gtt ttt tca gtg ttg     1239
 Ile Leu Gln Glu Gln Lys Thr Val Leu Ala Ser Val Phe Ser Val Leu
              95                 100                 105

 tct gcc atc tat gcc tca cag act gag caa gag tat cta aag ata gaa     1287
 Ser Ala Ile Tyr Ala Ser Gln Thr Glu Gln Glu Tyr Leu Lys Ile Glu
         110                 115                 120

 aaa gta gat ctt cct cta att gac agc ctc att cgg gtc tta caa aat     1335
 Lys Val Asp Leu Pro Leu Ile Asp Ser Leu Ile Arg Val Leu Gln Asn
     125                 130                 135

 atg gaa cag tgt cag aaa aaa cca gag aac tcg gca gag tct aac aca     1383
 Met Glu Gln Cys Gln Lys Lys Pro Glu Asn Ser Ala Glu Ser Asn Thr
 140                 145                 150                 155

 gag gaa act aaa agg act gat tta acc caa gat gat ttc cac ttg aaa     1431
 Glu Glu Thr Lys Arg Thr Asp Leu Thr Gln Asp Asp Phe His Leu Lys
                 160                 165                 170

 atc tta aag gat att tta tgt gaa ttt ctt tct aat att ttt cag gca     1479
 Ile Leu Lys Asp Ile Leu Cys Glu Phe Leu Ser Asn Ile Phe Gln Ala
             175                 180                 185

 tta aca aag gag acg gtg gct cag gga gta aag gaa ggc cag ttg agc     1527
 Leu Thr Lys Glu Thr Val Ala Gln Gly Val Lys Glu Gly Gln Leu Ser
         190                 195                 200

 aaa cag aag tgt tcc tct gca ttt caa aac ctt ctt cct ttc tat agc     1575
 Lys Gln Lys Cys Ser Ser Ala Phe Gln Asn Leu Leu Pro Phe Tyr Ser
     205                 210                 215

 cct gtg gtg gaa gat ttt att aaa atc cta cgt gaa gtt gat aag gcg     1623
 Pro Val Val Glu Asp Phe Ile Lys Ile Leu Arg Glu Val Asp Lys Ala
 220                 225                 230                 235

 ctt gct gat gac ttg gaa aaa aac ttc cca agt ttg aag gtt cag act     1671
 Leu Ala Asp Asp Leu Glu Lys Asn Phe Pro Ser Leu Lys Val Gln Thr
                 240                 245                 250

 taa aacc tgaattggaa ttacttctgt acaagaaata aactttattt ttctcactga     1728
 


 aaaaaaaaaa g                                                        1739




      <210> 70
      <211> 1258
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (351)..(839)

      <400> 70
 tttcgttccc agaacacgaa ggggggaaaa aacgcttcta atgatccctc agaacctgca     60

 tattttcata cgcttttctg gggggaggca ctaattgggg cgcttttcct ttgcgaactt    120

 acttatctta aagtcggagc ggaaaataaa gcacgcacgc aacccaattt ccggagaacc    180

 gagattgcga cgaacaacca ggaagcggct gggttgagag ctgtccccgg ttctccgttc    240

 tgctctcggg ggcaccttcc ggggttccta agccgcgggg cccctcgctg cccctcgagg    300

 ccctttccct gacctaggct ttggcctggg ctactcgttc cggagccgcc   atg tcg     356
                                                          Met Ser
                                                            1

 tcc gac ttc gaa ggt tac gag cag gac ttc gcg gtg ctc act gca gag      404
 Ser Asp Phe Glu Gly Tyr Glu Gln Asp Phe Ala Val Leu Thr Ala Glu
           5                  10                  15

 atc acc agc aag att gcg agg gtc cca cga ctc ccg cct gat gaa aag      452
 Ile Thr Ser Lys Ile Ala Arg Val Pro Arg Leu Pro Pro Asp Glu Lys
      20                  25                  30

 aaa cag atg gtt gca aat gtg gag aaa cag ctt gaa gaa gcg aaa gaa      500
 Lys Gln Met Val Ala Asn Val Glu Lys Gln Leu Glu Glu Ala Lys Glu
  35                  40                  45                  50

 ctg ctt gaa cag atg gat ttg gaa gtc cga gag ata cca ccc caa agt      548
 Leu Leu Glu Gln Met Asp Leu Glu Val Arg Glu Ile Pro Pro Gln Ser
                  55                  60                  65

 cga ggg atg tac agc aac aga atg aga agc tac aaa caa gaa atg gga      596
 Arg Gly Met Tyr Ser Asn Arg Met Arg Ser Tyr Lys Gln Glu Met Gly
              70                  75                  80

 aaa ctc gaa aca gat ttt aaa agg tca cgg atc gcc tac agt gac gaa      644
 Lys Leu Glu Thr Asp Phe Lys Arg Ser Arg Ile Ala Tyr Ser Asp Glu
          85                  90                  95

 gta cgg aat gag ctc ctg ggg gat gat ggg aat tcc tca gag aac cag      692
 Val Arg Asn Glu Leu Leu Gly Asp Asp Gly Asn Ser Ser Glu Asn Gln
     100                 105                 110

 agg gca cat ctg ctc gat aac aca gag agg ctg gaa agg tca tct cgg      740
 Arg Ala His Leu Leu Asp Asn Thr Glu Arg Leu Glu Arg Ser Ser Arg
 115                 120                 125                 130

 aga cta gag gct gga tac caa ata gca gtg gaa acc ggt aag aat tct      788
 Arg Leu Glu Ala Gly Tyr Gln Ile Ala Val Glu Thr Gly Lys Asn Ser
                 135                 140                 145

 gag agt gag caa att gtc ttg ctt atg cac agc agt ctt cac aac aca      836
 Glu Ser Glu Gln Ile Val Leu Leu Met His Ser Ser Leu His Asn Thr
             150                 155                 160

 tga catt tcagggaaac ttcaaaggag tagcagagac agcagcccga gatgtggttt      893
 


 acatattggg gagacaattg ggagcttatt tgcgcttatc ttttttcaag ttaaaaggca    953

 tgacatctac tgaaaacagt tcctgaggtt taaaagtata catctgaaaa gagatggaat   1013

 actttgtcta aattctacat ttgtcttaat atgcagttac atgttgtcag tttacccccc   1073

 ccgaatgatt gctagcacat gggggaaatc tccagttttc tcctttaacg ttttaattca   1133

 catttttgta aaatttcaac ctttttaacc atccaaaatc tcttgtgaat ttgggggaaa   1193

 aggaattact aattccccct tttacttggg acatttgccc ccggtgttag gaaatgctcc   1253

 ccaaa                                                               1258




      <210> 71
      <211> 1479
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (336)..(1316)

      <400> 71
 tttcgtggaa gagccctaga gctttgcttt ttctctcctg cagcacttaa ccgaaaccag     60

 ttttgcaatc aattcctgtt cagaggccac cctactcttc ctatccgtct ttctccagcc    120

 cagacactca cagccccctg ccagaccagg ggacctcgga gaggcaagga cagaggttca    180

 ggatcttcct ctccctcggg acccaaggcc acaaaggaga gctccgtgga gagaagaaaa    240

 tcatttgact cctggggaca cagatttgct gccacagagg ctgatggaca accaggcgga    300

 gagagaaagt gaggctggtg ttggtttgca aaggg   atg agg atg acg ctc ctc     353
                                          Met Arg Met Thr Leu Leu
                                            1               5

 tgt gtg aag acg tgg agc tac aag acg gag atc tgt ccc ccg aag aaa      401
 Cys Val Lys Thr Trp Ser Tyr Lys Thr Glu Ile Cys Pro Pro Lys Lys
              10                  15                  20

 aaa ata ttt ttg aga gaa ttt ccc aga ttg aaa gaa gat ctg aaa ggg      449
 Lys Ile Phe Leu Arg Glu Phe Pro Arg Leu Lys Glu Asp Leu Lys Gly
          25                  30                  35

 aac att gac aag ctc cgt gcc ctc gca gac gat att gac aaa acc cac      497
 Asn Ile Asp Lys Leu Arg Ala Leu Ala Asp Asp Ile Asp Lys Thr His
      40                  45                  50

 aag aaa ttc acc aag gct aac atg gtg gcc acc tct act gct gtc atc      545
 Lys Lys Phe Thr Lys Ala Asn Met Val Ala Thr Ser Thr Ala Val Ile
  55                  60                  65                  70

 tct gga gtg atg agc ctc ctg ggt tta gcc ctt gcc cca gca aca gga      593
 Ser Gly Val Met Ser Leu Leu Gly Leu Ala Leu Ala Pro Ala Thr Gly
                  75                  80                  85

 gga gga agc ctg ctg ctc tcc acc gct ggt caa ggt ttg gca aca gca      641
 Gly Gly Ser Leu Leu Leu Ser Thr Ala Gly Gln Gly Leu Ala Thr Ala
              90                  95                 100

 gct ggg gtc acc agc atc gtg agt ggt acg ttg gaa cgc tcc aaa aat      689
 Ala Gly Val Thr Ser Ile Val Ser Gly Thr Leu Glu Arg Ser Lys Asn
         105                 110                 115

 aaa gaa gcc caa gca cgg gcg gaa gac ata ctg ccc acc tac gac caa      737
 Lys Glu Ala Gln Ala Arg Ala Glu Asp Ile Leu Pro Thr Tyr Asp Gln
     120                 125                 130

 gag gac agg gag gat gag gaa gag aag gca gac tat gtc aca gct gct      785
 Glu Asp Arg Glu Asp Glu Glu Glu Lys Ala Asp Tyr Val Thr Ala Ala
 135                 140                 145                 150

 gga aag att atc tat aat ctt aga aac acc ttg aag tat gcc aag aaa      833
 Gly Lys Ile Ile Tyr Asn Leu Arg Asn Thr Leu Lys Tyr Ala Lys Lys
                 155                 160                 165

 aac gtc cgt gca ttt tgg aaa ctc aga gcc aac cca cgc ttg gcc aat      881
 Asn Val Arg Ala Phe Trp Lys Leu Arg Ala Asn Pro Arg Leu Ala Asn
             170                 175                 180

 gct acc aag cgt ctt ctg acc act ggc caa gtc tcc tcc cgg agc cgc      929
 Ala Thr Lys Arg Leu Leu Thr Thr Gly Gln Val Ser Ser Arg Ser Arg
         185                 190                 195

 gtg cag gtg caa aag gcc ttt gcg gga aca aca ctg gcg atg acc aaa      977
 Val Gln Val Gln Lys Ala Phe Ala Gly Thr Thr Leu Ala Met Thr Lys
     200                 205                 210

 aat gct cgc gtg ctg gga ggt gtg atg tcc gcc ttc tcc ctt ggc tat     1025
 Asn Ala Arg Val Leu Gly Gly Val Met Ser Ala Phe Ser Leu Gly Tyr
 215                 220                 225                 230

 gac ttg gcc act ctc tca aag gaa tgg aag cac ctg aag gaa gga gca     1073
 Asp Leu Ala Thr Leu Ser Lys Glu Trp Lys His Leu Lys Glu Gly Ala
                 235                 240                 245

 agg aca aag ttt gcg gaa gag ttg aga gcc aag gcc ttg gag ctg gag     1121
 Arg Thr Lys Phe Ala Glu Glu Leu Arg Ala Lys Ala Leu Glu Leu Glu
             250                 255                 260

 agg aaa ctc aca gaa ctc acc cag ctc tac aag agc ttg cag cag aaa     1169
 Arg Lys Leu Thr Glu Leu Thr Gln Leu Tyr Lys Ser Leu Gln Gln Lys
         265                 270                 275

 gtg agg tca agg gcc aga ggg gtg ggg aag gat tta act ggg acc tgc     1217
 Val Arg Ser Arg Ala Arg Gly Val Gly Lys Asp Leu Thr Gly Thr Cys
     280                 285                 290

 gaa acc gag gct tac tgg aag gag tta agg gag cat gtg tgg atg tgg     1265
 Glu Thr Glu Ala Tyr Trp Lys Glu Leu Arg Glu His Val Trp Met Trp
 295                 300                 305                 310

 ctg tgg ctg tgt gtg tgt ctg tgt gtc tgt gtg tat gta cag ttt aca     1313
 Leu Trp Leu Cys Val Cys Leu Cys Val Cys Val Tyr Val Gln Phe Thr
                 315                 320                 325

 tga atgt tcctcaggac atggcataca atggccttgg aggtccaaat aatatcaagt     1370
 


 acatcttgga gatgagggtg cctgtcctgg acagacctcg gcatgccttc tgtttctcct   1430

 tcaatgctcc ttaaggccta tgtgctggga aaagggtctt ccctgtttg               1479




      <210> 72
      <211> 872
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (653)..(847)

      <400> 72
 caaagactgt taaataccac cagtccagct ttggcaaggc actgttggct ttgtttatct     60

 ccatcatcat ccaaacagac taccaatctt gatcccagcc caatcttggg cccttgaaaa    120

 aataacttaa catcctaact acaagggaga aactcctttc aaattaatga acctggctga    180

 cttatatagc cttaaaatta tggaaatgac aagggttaca atgtcagaat gagcagtaaa    240

 ccttccccag tcctatcaga gcaaactttc tggggttgca tcccctcaga aacccatttg    300

 gggcccaatc tcaatgcaca tatcagtgcg caaagcacta aaattccagg caacactttg    360

 tattgagaga agccaaaatt ttggtcaggc cctgggacat ctaaagtcac caatgtaact    420

 acaccataca gattaaaccc tcacatgatc atgtaagcta tgcagttacc caagctgcat    480

 catttagaaa acctgtacag tttttatgga aaccatccct agtcaaggac actttaaata    540

 tatagtctaa ataccgttaa ggtaggccca ctagctgtgt tcacattttc ccttggccac    600

 cttaccaggg actttaataa cttgggaaag tgaaaacaac aagctaaccc ac    atg     655
                                                              Met
                                                                1

 ttc acc ata gaa aac aat ttt gtc ttg aaa aac aag gac tct ttt tcc      703
 Phe Thr Ile Glu Asn Asn Phe Val Leu Lys Asn Lys Asp Ser Phe Ser
               5                  10                  15

 cgt gtg gga cca gtt cct act tat gtt tta cca gcc aat tgg act gga      751
 Arg Val Gly Pro Val Pro Thr Tyr Val Leu Pro Ala Asn Trp Thr Gly
          20                  25                  30

 acc tat aca gtt gtt tat tta gcc ccc gaa att aat ata gct ccc aac      799
 Thr Tyr Thr Val Val Tyr Leu Ala Pro Glu Ile Asn Ile Ala Pro Asn
      35                  40                  45

 aac caa tcc ttc att ata ctt tta act gca acc acc aga cac aaa tga      847
 Asn Gln Ser Phe Ile Ile Leu Leu Thr Ala Thr Thr Arg His Lys 
  50                  55                  60

 gccatccaac tgataccact ttcgg                                          872




      <210> 73
      <211> 896
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (68)..(484)

      <400> 73
 ccgacctggc cgcgcaccac cgccccttct cggccctcct gcgtttgccc agggtcggcc     60

 cgcagtg  atg gag gag gag gcg gag acc gag gag cag cag cga ttc tct     109
          Met Glu Glu Glu Ala Glu Thr Glu Glu Gln Gln Arg Phe Ser
            1               5                  10

 tac caa cag agg cta aag gca gca gtt cac tat act gtg ggt tgt ctt      157
 Tyr Gln Gln Arg Leu Lys Ala Ala Val His Tyr Thr Val Gly Cys Leu
  15                  20                  25                  30

 tgc gag gaa gtt gca ttg gac aaa gag atg cag ttc agc aaa cag acc      205
 Cys Glu Glu Val Ala Leu Asp Lys Glu Met Gln Phe Ser Lys Gln Thr
                  35                  40                  45

 att gcg gcc att tcg gag ctg act ttc cga cag tgt gaa aat ttt gcc      253
 Ile Ala Ala Ile Ser Glu Leu Thr Phe Arg Gln Cys Glu Asn Phe Ala
              50                  55                  60

 aaa gac ctt gaa atg ttt gca aga cat gcg aaa aga acc aca att aac      301
 Lys Asp Leu Glu Met Phe Ala Arg His Ala Lys Arg Thr Thr Ile Asn
          65                  70                  75

 act gaa gat gtg aag ctc tta gcc agg agg agt aat tca ctg cta aaa      349
 Thr Glu Asp Val Lys Leu Leu Ala Arg Arg Ser Asn Ser Leu Leu Lys
      80                  85                  90

 tac atc aca gac aaa agt gaa gag att gct cag att aac cta gaa cga      397
 Tyr Ile Thr Asp Lys Ser Glu Glu Ile Ala Gln Ile Asn Leu Glu Arg
  95                 100                 105                 110

 aaa gca cag aag aaa aag aag tca gag gat gga agc aaa aat tca agg      445
 Lys Ala Gln Lys Lys Lys Lys Ser Glu Asp Gly Ser Lys Asn Ser Arg
                 115                 120                 125

 cag cca gca gag gct gga gtg gtg gaa agt gag aat taa agtccctcgc       494
 Gln Pro Ala Glu Ala Gly Val Val Glu Ser Glu Asn 
             130                 135

 cgcttggaaa gtgcagcctt ctacaggtag agccacctag aaatgcatat ggctgcaaag    554

 gaaactttga agggttaaat agagatttaa aaaaataaaa taaaaaggct gggctagggt    614

 gctttttgtg ctgaattctc cacattgtta actgccaaag ctagttttag agaatgagaa    674

 agtcttaagc aaaatactcc caggtctcac tccagaacat aaaaatggtg tgtgatcgaa    734

 tggtatatat tagaaattac atctgttgta attaaaattg tgtgagcaat taaacatggt    794

 tgactttttc aagcaaaaat cagttcatct tttgatgtaa ttttctaggc taaatggcaa    854

 tctctgaaag atgaataaag ctatatttat ttaaaaaaaa aa                       896




      <210> 74
      <211> 434
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(387)

      <400> 74
  atg atg gat gtg tct ggt gtg ggt ttc cca agc aag gtt cct tgg aag      48
  Met Met Asp Val Ser Gly Val Gly Phe Pro Ser Lys Val Pro Trp Lys
    1               5                  10                  15

 aag atg tct gca gag gag ctg gag aat cag tac tgt ccc agc cga tgg       96
 Lys Met Ser Ala Glu Glu Leu Glu Asn Gln Tyr Cys Pro Ser Arg Trp
              20                  25                  30

 gtt gtc cga ctg gga gca gag gaa gcc ttg agg acc tac tca cag ata      144
 Val Val Arg Leu Gly Ala Glu Glu Ala Leu Arg Thr Tyr Ser Gln Ile
          35                  40                  45

 gga att gaa gcc acc aca agg gcc cgg gcc acc agg aag agc ctg ctg      192
 Gly Ile Glu Ala Thr Thr Arg Ala Arg Ala Thr Arg Lys Ser Leu Leu
      50                  55                  60

 cat gtc ccc tat gga gac ggc gaa ggg gag aaa gtg gac att tac ttc      240
 His Val Pro Tyr Gly Asp Gly Glu Gly Glu Lys Val Asp Ile Tyr Phe
  65                  70                  75                  80

 ccc gac gag tcg tct gaa gcc ttg cct ttc ttc ctg ttc ttt cac gga      288
 Pro Asp Glu Ser Ser Glu Ala Leu Pro Phe Phe Leu Phe Phe His Gly
                  85                  90                  95

 gga tac tgg cag agc gga aga ccc tgt gtc aag gag agt gga aag cct      336
 Gly Tyr Trp Gln Ser Gly Arg Pro Cys Val Lys Glu Ser Gly Lys Pro
             100                 105                 110

 cat ttg aag agc tcc acg atg tgg acc act ttg aaa ttg ttg aga atc      384
 His Leu Lys Ser Ser Thr Met Trp Thr Thr Leu Lys Leu Leu Arg Ile
         115                 120                 125

 tga cccagaagga caacgtgctc acccagatta tcttgaaaac aatcttg              434
 






      <210> 75
      <211> 742
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(513)

      <400> 75
  atg atg gat gtg tct ggt gtg ggt ttc cca agc aag gtt cct tgg aag      48
  Met Met Asp Val Ser Gly Val Gly Phe Pro Ser Lys Val Pro Trp Lys
    1               5                  10                  15

 aag atg tct gca gag gag ctg gag aat cag tac tgt ccc agc cga tgg       96
 Lys Met Ser Ala Glu Glu Leu Glu Asn Gln Tyr Cys Pro Ser Arg Trp
              20                  25                  30

 gtt gtc cga ctg gga gca gag gaa gcc ttg agg acc tac tca cag ata      144
 Val Val Arg Leu Gly Ala Glu Glu Ala Leu Arg Thr Tyr Ser Gln Ile
          35                  40                  45

 gga att gaa gcc acc aca agg gcc cgg gcc acc agg aag agc ctg ctg      192
 Gly Ile Glu Ala Thr Thr Arg Ala Arg Ala Thr Arg Lys Ser Leu Leu
      50                  55                  60

 cat gtc ccc tat gga gac ggc gaa ggg gag aaa gtg gac att tac ttc      240
 His Val Pro Tyr Gly Asp Gly Glu Gly Glu Lys Val Asp Ile Tyr Phe
  65                  70                  75                  80

 ccc gac gag tcg tct gaa gcc ttg cct ttc ttc ctg ttc ttt cac gga      288
 Pro Asp Glu Ser Ser Glu Ala Leu Pro Phe Phe Leu Phe Phe His Gly
                  85                  90                  95

 gga tac tgg cag agc gga agg cac cct gga cca cat ggt aga cca ggt      336
 Gly Tyr Trp Gln Ser Gly Arg His Pro Gly Pro His Gly Arg Pro Gly
             100                 105                 110

 gac ccg cag cgt tgc gtt tgt cca gaa gcg gta tcc aag caa caa acc      384
 Asp Pro Gln Arg Cys Val Cys Pro Glu Ala Val Ser Lys Gln Gln Thr
         115                 120                 125

 ctg tgt caa gga gag tgg aaa gcc tca ttt gaa gag ctc cac gat gtg      432
 Leu Cys Gln Gly Glu Trp Lys Ala Ser Phe Glu Glu Leu His Asp Val
     130                 135                 140

 gac cac ttt gaa att gtt gag aat ctg acc cag aag gac aac gtg ctc      480
 Asp His Phe Glu Ile Val Glu Asn Leu Thr Gln Lys Asp Asn Val Leu
 145                 150                 155                 160

 acc cag att atc ttg aaa aca atc ttc cag tag ttctgacg atacttggag      531
 Thr Gln Ile Ile Leu Lys Thr Ile Phe Gln 
                 165                 170

 cctggtccac gtgcatccca ccttgggaag cctctccaaa gagctttcgg agctgacact    591

 gacagcttca gtttccccca gcacccagga gagccttgct gtgtctgtct gcccggcaag    651

 agtccattct cactgctggg acactcatga aaatctccac gtcctccctc ttcccatcct    711

 ggatggagct ccagggctgg ggaacgtccg c                                   742




      <210> 76
      <211> 651
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (481)..(639)

      <400> 76
 aaatgtacta catttgcaga ttaactcata tcatatgcat attattggta actagcaatt     60

 cttaactgta cagatagttt caaactgcat ccagttttta caaataaatg ctcttgttta    120

 taaggaatac cataaagaga gcacatgtaa atgaagaaaa tcttgtcact tatactggaa    180

 attcaagcga gaatgatatt aaaaaaaaag ttgttaaagg caacacaaga agttaaatga    240

 aactgagtta gcaatgagag atattggcta atttactgtg cctaaaatta tggggctatt    300

 ggtctactgt ataattatta tttttaatgt ccagaatgtg taatacaagg gccagaactt    360

 cctcctggac tcaattttat aaattctcga ttagttggtg aggccaataa ggatactttt    420

 tctcgtctaa tttggtttct gggaaagctt cgttcaagtc ctcagtggtc atctgatcaa    480
                                                                 
 atg gaa tta agt tct tca tct tct cca tct gtt tct cat att cta caa      528
 Met Glu Leu Ser Ser Ser Ser Ser Pro Ser Val Ser His Ile Leu Gln
   1               5                  10                  15

 tcc tgg cct ttg aga gag aca ccc act cag cac aag att tca cat ctt      576
 Ser Trp Pro Leu Arg Glu Thr Pro Thr Gln His Lys Ile Ser His Leu
              20                  25                  30

 ttt ctt cgg cat cca cct gcg cag tat att tat cct ctg gca cgg gaa      624
 Phe Leu Arg His Pro Pro Ala Gln Tyr Ile Tyr Pro Leu Ala Arg Glu
          35                  40                  45

 cct tca ggg cat taa acttcttata gt                                    651
 Pro Ser Gly His 
      50





      <210> 77
      <211> 7366
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (399)..(4130)

      <400> 77
 cctgggggtg gaaccgggac tggcccccgc tctttgaagc caaagggtct gagctcttcc     60

 ccggtagacc agcaccacct gtgaatggag aggccagcgc ctgccccgcg ccgccgaccc    120

 acctggaccg gaccacatgc gcgcggcgcc ggccagcccg cctcccgccg ccatggggcg    180

 ctgcaggcat caggccggcg ccgcgggcct ctcgcgcctc cttctgggcc cgcttcccgc    240

 cgcactgttt tccttccggt tgttccggaa gtcgggtcct cgagggcggt gagatcggtt    300

 tccgattccg gggtggccgg gtggcggcgg cggcgctccg gtcgcgatgg gccagaggtg    360

 acgccgcagc cgccgggagc cgcgagggac ggggcagg    atg aac cgg gcc aag     413
                                              Met Asn Arg Ala Lys
                                                1               5

 ccc acc acg gtg cgc cgg ccc agc gcc gcg gcc aaa ccc tca ggg cac      461
 Pro Thr Thr Val Arg Arg Pro Ser Ala Ala Ala Lys Pro Ser Gly His
                  10                  15                  20

 cct ccc cca gga gac ttc att gct ctg ggc tca aag ggt cag gcc aat      509
 Pro Pro Pro Gly Asp Phe Ile Ala Leu Gly Ser Lys Gly Gln Ala Asn
              25                  30                  35

 gaa tcg aaa acg gcg tcc acc ctg ctg aag cca gcc cct tcc ggc ctg      557
 Glu Ser Lys Thr Ala Ser Thr Leu Leu Lys Pro Ala Pro Ser Gly Leu
          40                  45                  50

 cct tct gag cgc aag cgg gat gcg gcg gct gcg ttg tcc agt gcc tcg      605
 Pro Ser Glu Arg Lys Arg Asp Ala Ala Ala Ala Leu Ser Ser Ala Ser
      55                  60                  65

 gcc ctc acc ggt ctc acc aaa cgc ccc aaa ctc tcc tcc aca ccc cct      653
 Ala Leu Thr Gly Leu Thr Lys Arg Pro Lys Leu Ser Ser Thr Pro Pro
  70                  75                  80                  85

 ctg agt gcc ctg ggg cgc ctg gct gag gct gca gtg gca gaa aaa cga      701
 Leu Ser Ala Leu Gly Arg Leu Ala Glu Ala Ala Val Ala Glu Lys Arg
                  90                  95                 100

 gcc att tct ccg tcg att aaa gag cca tct gtg gtg cca att gaa gtg      749
 Ala Ile Ser Pro Ser Ile Lys Glu Pro Ser Val Val Pro Ile Glu Val
             105                 110                 115

 ctg ccc acg gtg ctg ctg gat gag atc gag gcg gcc gag ctg gag ggc      797
 Leu Pro Thr Val Leu Leu Asp Glu Ile Glu Ala Ala Glu Leu Glu Gly
         120                 125                 130

 aac gat gac agg atc gag ggc gtg ctg tgc ggg gcc gtg aag cag ctg      845
 Asn Asp Asp Arg Ile Glu Gly Val Leu Cys Gly Ala Val Lys Gln Leu
     135                 140                 145

 aag gtc acc cgc gcc aag cct gac agc acc ctc tac ctg agc ctc atg      893
 Lys Val Thr Arg Ala Lys Pro Asp Ser Thr Leu Tyr Leu Ser Leu Met
 150                 155                 160                 165

 tac ctg gcc aag atc aag ccc aac atc ttc gcc act gag ggc gtc att      941
 Tyr Leu Ala Lys Ile Lys Pro Asn Ile Phe Ala Thr Glu Gly Val Ile
                 170                 175                 180

 gag gct ctg tgt agc ctc ctg cgg cgg gac gcc tcc atc aac ttc aag      989
 Glu Ala Leu Cys Ser Leu Leu Arg Arg Asp Ala Ser Ile Asn Phe Lys
             185                 190                 195

 gcc aag ggg aac agc ctg gtg tct gtg ctg gcc tgt aac ctc ctc atg     1037
 Ala Lys Gly Asn Ser Leu Val Ser Val Leu Ala Cys Asn Leu Leu Met
         200                 205                 210

 gcc gcc tac gag gag gac gag aac tgg ccc gag atc ttt gtc aag gtg     1085
 Ala Ala Tyr Glu Glu Asp Glu Asn Trp Pro Glu Ile Phe Val Lys Val
     215                 220                 225

 tac atc gag gac tcc ctg ggg gag cgg atc tgg gtg gac agc cct cac     1133
 Tyr Ile Glu Asp Ser Leu Gly Glu Arg Ile Trp Val Asp Ser Pro His
 230                 235                 240                 245

 tgt aag acg ttt gtg gac aac atc cag acg gcc ttc aac acc aga atg     1181
 Cys Lys Thr Phe Val Asp Asn Ile Gln Thr Ala Phe Asn Thr Arg Met
                 250                 255                 260

 ccc ccc agg agc gtg ctg ctg cag ggg gag gcg ggc cgc gtt gcg ggc     1229
 Pro Pro Arg Ser Val Leu Leu Gln Gly Glu Ala Gly Arg Val Ala Gly
             265                 270                 275

 gac ctg ggt gca ggg agc agc cca cac ccc tcc ctc acg gag gag gag     1277
 Asp Leu Gly Ala Gly Ser Ser Pro His Pro Ser Leu Thr Glu Glu Glu
         280                 285                 290

 gac agc cag acg gag ttg ctg atc gcg gag gag aag ctg agc ccc gag     1325
 Asp Ser Gln Thr Glu Leu Leu Ile Ala Glu Glu Lys Leu Ser Pro Glu
     295                 300                 305

 cag gag ggc cag ctc atg ccc agg tac gaa gag ctc gcg gag agc gtg     1373
 Gln Glu Gly Gln Leu Met Pro Arg Tyr Glu Glu Leu Ala Glu Ser Val
 310                 315                 320                 325

 gag gag tat gtc ctg gac atg ctg cgg gac cag ctg aac cgg cgc cag     1421
 Glu Glu Tyr Val Leu Asp Met Leu Arg Asp Gln Leu Asn Arg Arg Gln
                 330                 335                 340

 ccc atc gac aac gtc tcc agg aac ctc ctg cgg ctc ctc acc tcc acc     1469
 Pro Ile Asp Asn Val Ser Arg Asn Leu Leu Arg Leu Leu Thr Ser Thr
             345                 350                 355

 tgc ggc tat aag gag gtg cgg ctg ctg gcg gtg cag aag ctg gag atg     1517
 Cys Gly Tyr Lys Glu Val Arg Leu Leu Ala Val Gln Lys Leu Glu Met
         360                 365                 370

 tgg ctg cag aac ccc aag ctg acc cgg ccg gcc cag gac ctg ctg atg     1565
 Trp Leu Gln Asn Pro Lys Leu Thr Arg Pro Ala Gln Asp Leu Leu Met
     375                 380                 385

 tcc gtc tgc atg aac tgc aac acg cac ggt tcc gaa gac atg gac gtc     1613
 Ser Val Cys Met Asn Cys Asn Thr His Gly Ser Glu Asp Met Asp Val
 390                 395                 400                 405

 atc tca cac ctg atc aag atc cgc ctc aag ccc aag gtc ctc ctc aac     1661
 Ile Ser His Leu Ile Lys Ile Arg Leu Lys Pro Lys Val Leu Leu Asn
                 410                 415                 420

 cac ttc atg ctg tgc atc agg gag ctg ctg agc gcg cac aag gac aac     1709
 His Phe Met Leu Cys Ile Arg Glu Leu Leu Ser Ala His Lys Asp Asn
             425                 430                 435

 ctg ggc acc acc atc aag ttg gtg atc ttc aat gag ctc tcc agc gcc     1757
 Leu Gly Thr Thr Ile Lys Leu Val Ile Phe Asn Glu Leu Ser Ser Ala
         440                 445                 450

 cgg aac ccg aac aac atg cag gtc ctc tat acc gca ctg cag cac agc     1805
 Arg Asn Pro Asn Asn Met Gln Val Leu Tyr Thr Ala Leu Gln His Ser
     455                 460                 465

 tca gag ctg gcg ccc aag ttc ctg gcc atg gtg ttc cag gac ctg ctg     1853
 Ser Glu Leu Ala Pro Lys Phe Leu Ala Met Val Phe Gln Asp Leu Leu
 470                 475                 480                 485

 acc aac aag gac gac tac ctg cgg gcc tcg cgg gcc ctg ctg cgg gag     1901
 Thr Asn Lys Asp Asp Tyr Leu Arg Ala Ser Arg Ala Leu Leu Arg Glu
                 490                 495                 500

 atc atc aag cag acc aag cac gag atc aac ttc cag gcc ttc tgc ctg     1949
 Ile Ile Lys Gln Thr Lys His Glu Ile Asn Phe Gln Ala Phe Cys Leu
             505                 510                 515

 ggg ctc atg cag gag cgc aag gag ccg cag tac ctg gag atg gag ttc     1997
 Gly Leu Met Gln Glu Arg Lys Glu Pro Gln Tyr Leu Glu Met Glu Phe
         520                 525                 530

 aag acc ccg tgc cgc gcc cac gtg ggt gtg gag tgg ggc tcc cgg gtg     2045
 Lys Thr Pro Cys Arg Ala His Val Gly Val Glu Trp Gly Ser Arg Val
     535                 540                 545

 tcc ctt ctg gat aca gac ccc gtg ctg cac ctg cag gag cgc ttc gtg     2093
 Ser Leu Leu Asp Thr Asp Pro Val Leu His Leu Gln Glu Arg Phe Val
 550                 555                 560                 565

 gtg cac atc acc gac gtc ctg gcc gtg tcc atg atg ctg ggc atc aca     2141
 Val His Ile Thr Asp Val Leu Ala Val Ser Met Met Leu Gly Ile Thr
                 570                 575                 580

 gcg cag gtg aag gag gcc ggc atc gcc tgg gac aaa gga gaa aag agg     2189
 Ala Gln Val Lys Glu Ala Gly Ile Ala Trp Asp Lys Gly Glu Lys Arg
             585                 590                 595

 aac ctg gaa gtg ctc cgc tca ttc cag aac cag att gcc gcc atc cag     2237
 Asn Leu Glu Val Leu Arg Ser Phe Gln Asn Gln Ile Ala Ala Ile Gln
         600                 605                 610

 cgg gat gcc gtc tgg tgg ctc cac act gtg gtc ccc tcc atc agc aag     2285
 Arg Asp Ala Val Trp Trp Leu His Thr Val Val Pro Ser Ile Ser Lys
     615                 620                 625

 ctc gcc cct aag gac tac gtg cac tgc ctg cac aag gtg ctg ttc aca     2333
 Leu Ala Pro Lys Asp Tyr Val His Cys Leu His Lys Val Leu Phe Thr
 630                 635                 640                 645

 gag cag ccg gag acc tac tac aag tgg gac aac tgg cca ccc gag agt     2381
 Glu Gln Pro Glu Thr Tyr Tyr Lys Trp Asp Asn Trp Pro Pro Glu Ser
                 650                 655                 660

 gac cgc aac ttc ttc ctg cgt ctg tgc tcc gag gtg ccc att ttg gag     2429
 Asp Arg Asn Phe Phe Leu Arg Leu Cys Ser Glu Val Pro Ile Leu Glu
             665                 670                 675

 gac acg ctg atg cgc atc ctg gtc atc ggg ctg tcc cgg gag ctc ccg     2477
 Asp Thr Leu Met Arg Ile Leu Val Ile Gly Leu Ser Arg Glu Leu Pro
         680                 685                 690

 ctc ggg cct gcg gac gcc atg gag ctt gct gac cac ctg gtg aag cgg     2525
 Leu Gly Pro Ala Asp Ala Met Glu Leu Ala Asp His Leu Val Lys Arg
     695                 700                 705

 gcg gct gcc gtg cag gcg gat gat gtg gag gtg ctg aag gtg ggg agg     2573
 Ala Ala Ala Val Gln Ala Asp Asp Val Glu Val Leu Lys Val Gly Arg
 710                 715                 720                 725

 acc cag ctg atc gac gcc gtt ctg aat ctg tgc acc tac cat cac cct     2621
 Thr Gln Leu Ile Asp Ala Val Leu Asn Leu Cys Thr Tyr His His Pro
                 730                 735                 740

 gaa aac atc cag ctc cca ccg ggg tac cag cct ccg aac ctc gcc atc     2669
 Glu Asn Ile Gln Leu Pro Pro Gly Tyr Gln Pro Pro Asn Leu Ala Ile
             745                 750                 755

 tct acc ctc tac tgg aag gcc tgg ccc ctc ctg ctg gtc gtc gcc gca     2717
 Ser Thr Leu Tyr Trp Lys Ala Trp Pro Leu Leu Leu Val Val Ala Ala
         760                 765                 770

 ttc aac cca gag aac atc ggc ctg gct gcg tgg gag gag tac ccg acc     2765
 Phe Asn Pro Glu Asn Ile Gly Leu Ala Ala Trp Glu Glu Tyr Pro Thr
     775                 780                 785

 ctg aag atg ctc atg gag atg gtg atg acc aac aac tac tcc tac cca     2813
 Leu Lys Met Leu Met Glu Met Val Met Thr Asn Asn Tyr Ser Tyr Pro
 790                 795                 800                 805

 ccg tgc acc ctg acg gat gag gag acc cgg acg gag atg ctg aac cgt     2861
 Pro Cys Thr Leu Thr Asp Glu Glu Thr Arg Thr Glu Met Leu Asn Arg
                 810                 815                 820

 gag ctg cag acc gcc cag cgg gag aag cag gag atc ctg gcc ttc gag     2909
 Glu Leu Gln Thr Ala Gln Arg Glu Lys Gln Glu Ile Leu Ala Phe Glu
             825                 830                 835

 ggg cac ctg gcg gcc gcg tcc acc aag cag acc atc act gag agc agc     2957
 Gly His Leu Ala Ala Ala Ser Thr Lys Gln Thr Ile Thr Glu Ser Ser
         840                 845                 850

 agc ctc ctc ctg tcg cag ctc acc agc ctg gac ccc cag ggg ccc ccc     3005
 Ser Leu Leu Leu Ser Gln Leu Thr Ser Leu Asp Pro Gln Gly Pro Pro
     855                 860                 865

 cgg agg cct ccc cct cac atc ctg gat caa gtg aaa agc ctc aac cag     3053
 Arg Arg Pro Pro Pro His Ile Leu Asp Gln Val Lys Ser Leu Asn Gln
 870                 875                 880                 885

 tcc ctc cgc ctc ggg cac ctc ttg tgc cgc agc cga aac cct gac ttt     3101
 Ser Leu Arg Leu Gly His Leu Leu Cys Arg Ser Arg Asn Pro Asp Phe
                 890                 895                 900

 ctc ctc cac atc atc cag cgg cag gcc tcc tcg cag tcc atg ccc tgg     3149
 Leu Leu His Ile Ile Gln Arg Gln Ala Ser Ser Gln Ser Met Pro Trp
             905                 910                 915

 ctg gcg gac ctg gta cag tcc agc gag ggc tcc ctg gac gtg ctg ccc     3197
 Leu Ala Asp Leu Val Gln Ser Ser Glu Gly Ser Leu Asp Val Leu Pro
         920                 925                 930

 gtg cag tgt ctg tgc gag ttc ctg ctg cac gat gct gtg gac gat gct     3245
 Val Gln Cys Leu Cys Glu Phe Leu Leu His Asp Ala Val Asp Asp Ala
     935                 940                 945

 gct tcc ggg gag gag gac gac gag ggc gag agc aag gag cag aag gcc     3293
 Ala Ser Gly Glu Glu Asp Asp Glu Gly Glu Ser Lys Glu Gln Lys Ala
 950                 955                 960                 965

 aag aag cgg cag agg caa cag aag cag cgg cag ctg ctg ggc cgc ctg     3341
 Lys Lys Arg Gln Arg Gln Gln Lys Gln Arg Gln Leu Leu Gly Arg Leu
                 970                 975                 980

 cag gac ctg cta ctg ggc ccg aag gct gat gag cag acc acg tgt gag     3389
 Gln Asp Leu Leu Leu Gly Pro Lys Ala Asp Glu Gln Thr Thr Cys Glu
             985                 990                 995

 gtg ctg gac tac ttc ttg cgg cgc ctc ggc tcc tcc cag gtg gcc tcc     3437
 Val Leu Asp Tyr Phe Leu Arg Arg Leu Gly Ser Ser Gln Val Ala Ser
        1000                1005                1010

 cgc gtg ctg gcc atg aag ggt ttg tcg ctg gtg ctt tcg gag ggc agc     3485
 Arg Val Leu Ala Met Lys Gly Leu Ser Leu Val Leu Ser Glu Gly Ser
    1015                1020                1025

 ctg cgg gac ggg gag gag aag gag ccc ccc atg gag gag gat gtg ggg     3533
 Leu Arg Asp Gly Glu Glu Lys Glu Pro Pro Met Glu Glu Asp Val Gly
1030                1035                1040                1045

 gac aca gat gtg ctg cag ggc tat cag tgg ctg ctg cgg gac ctg cct     3581
 Asp Thr Asp Val Leu Gln Gly Tyr Gln Trp Leu Leu Arg Asp Leu Pro
                1050                1055                1060

 cgc ctg cct ctg ttc gac agc gtc agg agc acc aca gcc ctg gcc ctg     3629
 Arg Leu Pro Leu Phe Asp Ser Val Arg Ser Thr Thr Ala Leu Ala Leu
            1065                1070                1075

 cag cag gca atc cac atg gag act gat ccc cag acc atc agc gcc tac     3677
 Gln Gln Ala Ile His Met Glu Thr Asp Pro Gln Thr Ile Ser Ala Tyr
        1080                1085                1090

 ctg atc tac ttg tcc cag cac acg cct gtg gag gag cag gcc cag cac     3725
 Leu Ile Tyr Leu Ser Gln His Thr Pro Val Glu Glu Gln Ala Gln His
    1095                1100                1105

 agc gac ctg gcc ctg gac gtg gcc cgg ctg gtc gtg gag cgc tcc acc     3773
 Ser Asp Leu Ala Leu Asp Val Ala Arg Leu Val Val Glu Arg Ser Thr
1110                1115                1120                1125

 atc atg tcc cac ctc ttc tcg aag ctc tcc ccg agt gcc gcg tcg gac     3821
 Ile Met Ser His Leu Phe Ser Lys Leu Ser Pro Ser Ala Ala Ser Asp
                1130                1135                1140

 gcc gtg ctg agc gct ctg ttg tcc atc ttc tca cgc tac gtg agg cgc     3869
 Ala Val Leu Ser Ala Leu Leu Ser Ile Phe Ser Arg Tyr Val Arg Arg
            1145                1150                1155

 atg cgg cag agc aag gag ggc gag gag gtc tac agc tgg tcg gag tct     3917
 Met Arg Gln Ser Lys Glu Gly Glu Glu Val Tyr Ser Trp Ser Glu Ser
        1160                1165                1170

 cag gac cag gtc ttc cta cgc tgg agc agc ggg gag aca gcc acc atg     3965
 Gln Asp Gln Val Phe Leu Arg Trp Ser Ser Gly Glu Thr Ala Thr Met
    1175                1180                1185

 cac atc ctc gtg gtc cat gcc atg gtg atc ctg ctg acg ctg ggc ccg     4013
 His Ile Leu Val Val His Ala Met Val Ile Leu Leu Thr Leu Gly Pro
1190                1195                1200                1205

 cct cga gcc gac gac agc gag ttc cag gcg ctg ctg gac atc tgg ttt     4061
 Pro Arg Ala Asp Asp Ser Glu Phe Gln Ala Leu Leu Asp Ile Trp Phe
                1210                1215                1220

 ccg gag gag aag cca ctg ccc acc gcc ttc ctg gtg gac aca tcg gag     4109
 Pro Glu Glu Lys Pro Leu Pro Thr Ala Phe Leu Val Asp Thr Ser Glu
            1225                1230                1235

 gca ggc gct gct gct tcc tga ct ggctgaagct gcgcatgatc cgttctgagg     4162
 Ala Gly Ala Ala Ala Ser 
        1240

 tgctccgcct ggtggacgcc gccctgcagg acctggagcc gcagcagctg ctgctgttcg   4222

 tgcagtcgtt tggcatcccc gtgtccagca tgagcaaact cctccagttc ctggaccagg   4282

 cagtggccca cgacccccag actctggagc agaacatcat ggacaagaat tacatggccc   4342

 acctggtgga ggtccagcat gagcgcggcg cctccggagg ccagactttc cactccttgc   4402

 tcacagcctc cctgccgccc cgccgagaca gcacagaggc acccaaacca aagagcagcc   4462

 cagagcagcc cataggccag ggccggattc gggtggggac ccagctccgg gtgctgggcc   4522

 ctgaggacga cctggctggc atgttcctcc agattttccc gctcagcccg gaccctcggt   4582

 ggcagagctc cagtccccgc cccgtggccc tcgccctgca gcaggccctg ggccaggagc   4642

 tggcccgcgt cgtccagggc agccccgagg tgccgggcat cacggtgcgt gtcctgcagg   4702

 ccctcgccac cctgctcagc tccccacacg gcggtgccct ggtgatgtcc atgcaccgta   4762

 gccacttcct ggcctgcccg ctgctgcgcc agctctgcca gtaccagcgc tgtgtgccac   4822

 aggacaccgg cttctcctcg ctcttcctga aggtgctcct gcagatgctg cagtggctgg   4882

 acagccctgg cgtggagggc gggcccctgc gggcacagct caggatgctt gccagccagg   4942

 cctcagccgg gcgcaggctc agtgatgtgc gaggggggct cctgcgcctg gccgaggccc   5002

 tggccttccg tcaggacctg gaggtggtca gctccaccgt ccgtgccgtc atcgccaccc   5062

 tgaggtctgg ggagcagtgc agcgtggagc cggacctgat cagcaaagtc ctccaggggc   5122

 tgatcgaggt gaggtccccc cacctggagg agctgctgac tgcattcttc tctgccactg   5182

 cggatgctgc ctccccgttt ccagcctgta agcccgttgt ggtggtgagc tccctgctgc   5242

 tgcaggagga ggagcccctg gctgggggga agccgggtgc ggacggtggc agcctggagg   5302

 ccgtgcggct ggggccctcg tcaggcctcc tagtggactg gctggaaatg ctggaccccg   5362

 aggtggtcag cagctgcccc gacctgcagc tcaggctgct cttctcccgg aggaagggca   5422

 aaggtcaggc ccaggtgccc tcgttccgtc cctacctcct gaccctcttc acgcatcagt   5482

 ccagctggcc cacactgcac cagtgcatcc gagtcctgct gggcaagagc cgggaacaga   5542

 ggttcgaccc ctctgcctct ctggacttcc tctgggcctg catccatgtt cctcgcatct   5602

 ggcaggggcg ggaccagcgc accccgcaga agcggcggga ggagctggtg ctgcgggtcc   5662

 agggcccgga gctcatcagc ctggtggagc tgatcctggc cgaggcggag acgcggagcc   5722

 aggacgggga cacagccgcc tgcagcctca tccaggcccg gctgcccctg ctgctcagct   5782

 gctgctgtgg ggacgatgag agtgtcagga aggtgacgga gcacctgtca ggctgcatcc   5842

 agcagtgggg agacagcgtg ctgggcaggc gctgccgaga ccttctcctg cagctctacc   5902

 tacagcggcc ggagctgcgg gtgcccgtgc ctgaggtcct actgcacagc gaaggggctg   5962

 ccagcagcag cgtctgcaag ctggacggac tcatccaccg cttcatcacg ctccttgcgg   6022

 acaccagcga ctcccgggcg ttggagaacc gaggggcgga tgccagcatg gcctgccgga   6082

 agctggcggt ggcgcacccg ctgctgctgc tcaggcacct gcccatgatc gcggcgctcc   6142

 tgcacggccg cacccacctc aacttccagg agttccggca gcagaaccac ctgagctgct   6202

 tcctgcacgt gctgggcctg ctggagctgc tgcagccgca cgtgttccgc agcgagcacc   6262

 agggggcgct gtgggactgc cttctgtcct tcatccgcct gctgctgaat tacaggaagt   6322

 cctcccgcca tctggctgcc ttcatcaaca agtttgtgca gttcatccat aagtacatta   6382

 cctacaatgc cccagcagcc atctccttct tgcagaagca cgccgacccg ctccacgacc   6442

 tgtccttcga caacagtgac ctggtgatgc tgaaatccct ccttgcaggg ctcagcctgc   6502

 ccagcaggga cgacaggacc gaccgaggcc tggacgaaga gggcgaggag gagagctcag   6562

 ccggctcctt gcccctggtc agcgtctccc tgttcacccc tctgaccgcg gccgagatgg   6622

 ccccctacat gaaacggctt tcccggggcc aaacggtgga ggatctgctg gaggttctga   6682

 gtgacataga cgagatgtcc cggcggagac ccgagatcct gagcttcttc tcgaccaacc   6742

 tgcagcggct gatgagctcg gccgaggagt gttgccgcaa cctcgccttc agcctggccc   6802

 tgcgctccat gcagaacagc cccagcattg cagccgcttt cctgcccacg ttcatgtact   6862

 gcctgggcag ccaggacttt gaggtggtgc agacggccct ccggaacctg cctgagtacg   6922

 ctctcctgtg ccaagagcac gcggctgtgc tgctccaccg ggccttcctg gtgggcatgt   6982

 acggccagat ggaccccagc gcgcagatct ccgaggccct gaggatcctg catatggagg   7042

 ccgtgatgtg agcctgtggc agccgacccc cctccaagcc ccggcccgtc ccgtccccgg   7102

 ggatcctcga ggcaaagccc aggaagcgtg ggcgttgctg gtctgtccga ggaggtgagg   7162

 gcgccgagcc ctgaggccag gcaggcccag gagcaatact ccgagccctg gggtggctcc   7222

 gggccggccg ctggcatcag gggccgtcca gcaagccctc attcaccttc tgggccacag   7282

 ccctgccgcg gagcggcgga tccccccggg catggcctgg gctggttttg aatgaaacga   7342

 cctgaactgt caaaaaaaaa aaaa                                          7366




      <210> 78
      <211> 801
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (348)..(755)

      <400> 78
 tggacatccc agggcgacta gaggtggcag tatcgcgaat ttgcaggttt attgaacaag     60

 aggtaacatc ggagaggatc ttgccttcgg attcagcaag tatgaaggca gaagagcatg    120

 gagagcaagg ccccacagcc tgcttagtga gttggaaggc ccagcaagaa cctgtttctg    180

 cagcagccac cagctcccat caccccttga ccctccagct catgctggag aagagggaat    240

 tttggctgtt taaagaacac agttgtgaat ctcagaatgt gcctgaaagg aatactgaca    300

 gataaggccg gaaacaaaac tgatggcttg aaaaacattt ttatgga  atg tat tta     356
                                                      Met Tyr Leu
                                                        1

 cta tca ttt tgt ttt act ata gag gta gat ggg act ctt aac ttt tgg      404
 Leu Ser Phe Cys Phe Thr Ile Glu Val Asp Gly Thr Leu Asn Phe Trp
       5                  10                  15

 gta cat gga aac atg ctg aaa act gaa cac aat cct gat cat cac tcc      452
 Val His Gly Asn Met Leu Lys Thr Glu His Asn Pro Asp His His Ser
  20                  25                  30                  35

 tgc ctg gct gtc tcc tgg gag gct gcc ggg tgc cac gga gct ggg aca      500
 Cys Leu Ala Val Ser Trp Glu Ala Ala Gly Cys His Gly Ala Gly Thr
                  40                  45                  50

 cag cag agc ccg cta ggt gtt gca ggg ccc tgg agg cca agg cca ccc      548
 Gln Gln Ser Pro Leu Gly Val Ala Gly Pro Trp Arg Pro Arg Pro Pro
              55                  60                  65

 tgt gtg ggg tcc ctg ttg gca gcc agg tcc cta cac aaa caa gta atc      596
 Cys Val Gly Ser Leu Leu Ala Ala Arg Ser Leu His Lys Gln Val Ile
          70                  75                  80

 ctg ttt ggc ctc cta agt ttt gca tat gac ctg cag cct aat ttg ggg      644
 Leu Phe Gly Leu Leu Ser Phe Ala Tyr Asp Leu Gln Pro Asn Leu Gly
      85                  90                  95

 tgt agg gga agc tct gct ggc ccc tgc tcc ttt gta tgt tgg gtg act      692
 Cys Arg Gly Ser Ser Ala Gly Pro Cys Ser Phe Val Cys Trp Val Thr
 100                 105                 110                 115

 tta atg gct ggc cac ata ccc ctt tct ccc agc tac tca ttc act gac      740
 Leu Met Ala Gly His Ile Pro Leu Ser Pro Ser Tyr Ser Phe Thr Asp
                 120                 125                 130

 ttg agt aag ttc taa gacagttcgc acttagaata gaatgtgaca catcaccatt      795
 Leu Ser Lys Phe 
             135

 aacttt                                                               801




      <210> 79
      <211> 1123
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (550)..(825)

      <400> 79
 gcacgaggag ggacttggtc tccttgtctg gtacttgtgt acatgccggt gacctgagga     60

 ctccactcac actggcgagc aaaaagggag cagtgattct cttttctctc cccaccccct    120

 gccctttgtt accaacacca gtttcccagg gggtacatga gtttctgaat ttttaaaaaa    180

 tgtttttggt ttggtttttc tggggactga taagtgcttt aagcaatgtc cataccccgt    240

 caagactccc agcttagtca ttttcttgta tttttctgtt cacagtattt gtgtgtgtgc    300

 ttgttttggc agctcatttt ggctgtatta tatattgagt gatgaattga tcctcttttt    360

 tccctaaggg atatgaattg tttttcttgt gttatattct gcttgtgaat agctggagca    420

 aacctggggc tgacacgcgt aagctagggc tgcaaagcga gaagagagcc ggtggagtgt    480

 acttgtccct gacaggctga cctacctgag tctctgagct tttcagtcca aatctttgca    540

 aggctcaaa    atg cca cag aac ctc tcc tct tct ccc cac tcc cca tgg     588
              Met Pro Gln Asn Leu Ser Ser Ser Pro His Ser Pro Trp
                1               5                  10

 cag gga ccg gac cat ccc tac atg caa cat gct gtt cct cca gcc cct      636
 Gln Gly Pro Asp His Pro Tyr Met Gln His Ala Val Pro Pro Ala Pro
      15                  20                  25

 ccc att gcc atg gca aaa cag gta cct ttg ggg cat ggg ggc att aca      684
 Pro Ile Ala Met Ala Lys Gln Val Pro Leu Gly His Gly Gly Ile Thr
  30                  35                  40                  45

 tgg gat gct tgt gta atc gac cac cta gcc ttc tct ctc ccc tcc cgt      732
 Trp Asp Ala Cys Val Ile Asp His Leu Ala Phe Ser Leu Pro Ser Arg
                  50                  55                  60

 cct ccc cca gaa tca ctt cct agg aca ccc gag ctg ctt gcc cag ggt      780
 Pro Pro Pro Glu Ser Leu Pro Arg Thr Pro Glu Leu Leu Ala Gln Gly
              65                  70                  75

 cct gtt tcc ctg cta act cca gag aag cat ccc agg gct ttg tga cag      828
 Pro Val Ser Leu Leu Thr Pro Glu Lys His Pro Arg Ala Leu 
          80                  85                  90

 tctctaattc ccttcccttc tcgttaagaa tcatattgta tagtagcttt cagaccatac    888

 agtattcatt gggttactcc tattattatc aagtagctgg aattgtgaag gtcggagtag    948

 ttagatcttt agcttttatt ccttattttt ttgtattact ctccatgtgt ataaattatt   1008

 gatcatgttg ctggctttta taaactctaa gcgaaggagg agcactgcct cagcctttgc   1068

 acatggtaat gaagcactgt ttttaaataa aagagagaaa caccaaaaaa aaaaa        1123




      <210> 80
      <211> 1720
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (359)..(1036)

      <400> 80
 ctgtcccatg tgacccctga cccactggtg gccacaggag gagagagagg tgccctctct     60

 gggtccttat tctccacatc tgaggccacc acggacctaa caggcgaagg ccatctccct    120

 ccgggcttgg gtccggtggc gctggcggag caaggctccg gggcatctct ggctcgtgtg    180

 gtcgtgccaa gggtgccatt gcggatggac ggggccatgc gggccggcac ctctcgacga    240

 cgcaccgggg cgctgcgagg ggctcggtcc cggggcgcgc cggcgattgg cgggggaacc    300

 ggacccgggg gcgcggccgc ccgcggattg gcgaggcacg gcgggggcgg gctcgcgc      358                                                                 
 atg ctc tta agt ggc agc ggc ggg gac ggg gtc agt gcc aag atg tcg      406
 Met Leu Leu Ser Gly Ser Gly Gly Asp Gly Val Ser Ala Lys Met Ser
   1               5                  10                  15

 acg gcg gcg gtt ccg gag ctg aag cag atc agc cgg gtg gag gcg atg      454
 Thr Ala Ala Val Pro Glu Leu Lys Gln Ile Ser Arg Val Glu Ala Met
              20                  25                  30

 cgc cta ggg ccg ggc tgg agc cac tcg tgc cac gcc atg ctg tac gcc      502
 Arg Leu Gly Pro Gly Trp Ser His Ser Cys His Ala Met Leu Tyr Ala
          35                  40                  45

 gcc aac cct ggg cag ctc ttc ggc cgc atc ccc atg cgc ttc tcg gtg      550
 Ala Asn Pro Gly Gln Leu Phe Gly Arg Ile Pro Met Arg Phe Ser Val
      50                  55                  60

 ctg atg cag atg cgt ttc gac ggg ctg ctg ggc ttc ccc ggg ggc ttc      598
 Leu Met Gln Met Arg Phe Asp Gly Leu Leu Gly Phe Pro Gly Gly Phe
  65                  70                  75                  80

 gtg gac cgg cgc ttc tgg tcg ctg gag gac ggc ctg aac cgg gtg ctg      646
 Val Asp Arg Arg Phe Trp Ser Leu Glu Asp Gly Leu Asn Arg Val Leu
                  85                  90                  95

 ggc ctg ggc ctg ggc tgc ctg cgc ctc acc gag gcc gac tac ctg agc      694
 Gly Leu Gly Leu Gly Cys Leu Arg Leu Thr Glu Ala Asp Tyr Leu Ser
             100                 105                 110

 tcg cac ctg acc gag ggc cca cac cgc gtc gtg gcg cac ctg tac gcg      742
 Ser His Leu Thr Glu Gly Pro His Arg Val Val Ala His Leu Tyr Ala
         115                 120                 125

 cgg cag ctg acg ctg gag cag ctg cac gcc gtg gag atc agc gcg gtg      790
 Arg Gln Leu Thr Leu Glu Gln Leu His Ala Val Glu Ile Ser Ala Val
     130                 135                 140

 cac tcg cgc gac cac ggc ctg gag gtg ctg ggc ctc gtg cgg gtc ccg      838
 His Ser Arg Asp His Gly Leu Glu Val Leu Gly Leu Val Arg Val Pro
 145                 150                 155                 160

 ctg tac acc cag aag gac cga gtc gga ggc ttc ccc aac ttc ctg agc      886
 Leu Tyr Thr Gln Lys Asp Arg Val Gly Gly Phe Pro Asn Phe Leu Ser
                 165                 170                 175

 aac gcc ttc gtg agc acg gct aag tgc cag ctc ctc ttt gcc ctc aag      934
 Asn Ala Phe Val Ser Thr Ala Lys Cys Gln Leu Leu Phe Ala Leu Lys
             180                 185                 190

 gtg ctc aac atg atg ccc gag gag aag ctg gtt gag gcc ctg gct gca      982
 Val Leu Asn Met Met Pro Glu Glu Lys Leu Val Glu Ala Leu Ala Ala
         195                 200                 205

 gcc acc gag aag cag aag aag gcc ctg gag aag ttg ctc ccg gcc tcc     1030
 Ala Thr Glu Lys Gln Lys Lys Ala Leu Glu Lys Leu Leu Pro Ala Ser
     210                 215                 220

 tct tga gggctgcctg agctggtggc accctcccct gggccggaag actgggaatt      1086
 Ser 
 225

 cctgctaagt gtggcttcta gagtgtttgt gtgtaccccg cttctgactg cctagggcga   1146

 gtgggcatcc tgtcatcatc tccactgtcc caagcagtca ctaggtggcg gccgggccag   1206

 ctggaaccca gcccatcctc tcaggcagag cagggtggtc cgggcacact gggcctgcct   1266

 ctccagcctc aggatgctct tgtttattct gggctcagac cctcctcttg tacgtctcat   1326

 cacagctggt agagacccag gagtgcctga ttgtcccaca ggggtggcgc acagctctgg   1386

 gaccactcag aagatgggat gtgtgggtgg aggatgcctt gtctcggtca gctcattcct   1446

 gcctccttcc tgagccagtt cagggcctgg gggagagcca gcttggggta ggaagttaat   1506

 aatactgtta atttgggttg ttgttggatt tactttgcta gattttctct ttcaccacgt   1566

 gtgaactgtg ggtgaggttt caaagtagct tcaccccacg tggcttggtt cccagggaca   1626

 gtcagggcct cgggggccca gctatgtaca acgaagctgt cgaaggagaa gacaataaag   1686

 tcgctccgca gctgctctgt gaaaaaaaaa aaaa                               1720




      <210> 81
      <211> 1944
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (7)..(1524)

      <400> 81
 tttcgt   atg aag cgc acc ccg act gcc gag gaa cga gag cgc gaa gct      48
          Met Lys Arg Thr Pro Thr Ala Glu Glu Arg Glu Arg Glu Ala
            1               5                  10

 aag aaa ctg agg ctt ctt gaa gag ctt gaa gac act tgg ctc cct tat       96
 Lys Lys Leu Arg Leu Leu Glu Glu Leu Glu Asp Thr Trp Leu Pro Tyr
  15                  20                  25                  30

 ctg acc ccc aaa gat gat gaa ttc tat cag cag tgg cag ctg aaa tat      144
 Leu Thr Pro Lys Asp Asp Glu Phe Tyr Gln Gln Trp Gln Leu Lys Tyr
                  35                  40                  45

 cct aaa cta att ctc cga gaa gcc agc agt gta tct gag gag ctc cat      192
 Pro Lys Leu Ile Leu Arg Glu Ala Ser Ser Val Ser Glu Glu Leu His
              50                  55                  60

 aaa gag gtt caa gaa gcc ttt ctc aca ctg cac aag cat ggc tgc tta      240
 Lys Glu Val Gln Glu Ala Phe Leu Thr Leu His Lys His Gly Cys Leu
          65                  70                  75

 ttt cgg gac ctg gtt agg atc caa ggc aaa gat ctg ctc act ccg gta      288
 Phe Arg Asp Leu Val Arg Ile Gln Gly Lys Asp Leu Leu Thr Pro Val
      80                  85                  90

 tct cgc atc ctc att ggt aat cca ggc tgc acc tac aag tac ctg aac      336
 Ser Arg Ile Leu Ile Gly Asn Pro Gly Cys Thr Tyr Lys Tyr Leu Asn
  95                 100                 105                 110

 acc agg ctc ttt acg gtc ccc tgg cca gtg aaa ggg tct aat ata aaa      384
 Thr Arg Leu Phe Thr Val Pro Trp Pro Val Lys Gly Ser Asn Ile Lys
                 115                 120                 125

 cac acc gag gct gaa ata gcc gct gct tgt gag acc ttc ctc aag ctc      432
 His Thr Glu Ala Glu Ile Ala Ala Ala Cys Glu Thr Phe Leu Lys Leu
             130                 135                 140

 aat gac tac ctg cag ata gaa acc atc cag gct ttg gaa gaa ctt gct      480
 Asn Asp Tyr Leu Gln Ile Glu Thr Ile Gln Ala Leu Glu Glu Leu Ala
         145                 150                 155

 gcc aaa gag aag gct aat gag gat gct gtg cca ttg tgt atg tct gca      528
 Ala Lys Glu Lys Ala Asn Glu Asp Ala Val Pro Leu Cys Met Ser Ala
     160                 165                 170

 gat ttc ccc agg gtt ggg atg ggt tca tcc tac aac gga caa gat gaa      576
 Asp Phe Pro Arg Val Gly Met Gly Ser Ser Tyr Asn Gly Gln Asp Glu
 175                 180                 185                 190

 gtg gac att aag agc aga gca gca tac aac gta act ttg ctg aat ttc      624
 Val Asp Ile Lys Ser Arg Ala Ala Tyr Asn Val Thr Leu Leu Asn Phe
                 195                 200                 205

 atg gat cct cag aaa atg cca tac ctg aaa gag gaa cct tat ttt ggc      672
 Met Asp Pro Gln Lys Met Pro Tyr Leu Lys Glu Glu Pro Tyr Phe Gly
             210                 215                 220

 atg ggg aaa atg gca gtg agc tgg cat cat gat gaa aat ctg gtg gac      720
 Met Gly Lys Met Ala Val Ser Trp His His Asp Glu Asn Leu Val Asp
         225                 230                 235

 agg tca gcg gtg gca gtg tac agt tat agc tgt gaa ggc cct gaa gag      768
 Arg Ser Ala Val Ala Val Tyr Ser Tyr Ser Cys Glu Gly Pro Glu Glu
     240                 245                 250

 gaa agt gag gat gac tct cat ctc gaa ggc agg gat cct gat att tgg      816
 Glu Ser Glu Asp Asp Ser His Leu Glu Gly Arg Asp Pro Asp Ile Trp
 255                 260                 265                 270

 cat gtt ggt ttt aag atc tca tgg gac ata gag aca cct ggt ttg gcg      864
 His Val Gly Phe Lys Ile Ser Trp Asp Ile Glu Thr Pro Gly Leu Ala
                 275                 280                 285

 ata ccc ctt cac caa gga gac tgc tat ttc atg ctt gat gat ctc aat      912
 Ile Pro Leu His Gln Gly Asp Cys Tyr Phe Met Leu Asp Asp Leu Asn
             290                 295                 300

 gcc acc cac caa cac tgt gtt ttg gcc ggt tca caa cct cgg ttt agt      960
 Ala Thr His Gln His Cys Val Leu Ala Gly Ser Gln Pro Arg Phe Ser
         305                 310                 315

 tcc acc cac cga gtg gca gag tgc tca aca gga acc ttg gat tat att     1008
 Ser Thr His Arg Val Ala Glu Cys Ser Thr Gly Thr Leu Asp Tyr Ile
     320                 325                 330

 tta caa cgc tgt cag ttg gct ctg cag aat gtc tgt gac gat gtg gac     1056
 Leu Gln Arg Cys Gln Leu Ala Leu Gln Asn Val Cys Asp Asp Val Asp
 335                 340                 345                 350

 aat gat gat gtc tct ttg aaa tcc ttt gag cct gca gtt ttg aaa caa     1104
 Asn Asp Asp Val Ser Leu Lys Ser Phe Glu Pro Ala Val Leu Lys Gln
                 355                 360                 365

 gga gaa gaa att cat aat gag gtc gag ttt gag tgg ctg agg cag ttt     1152
 Gly Glu Glu Ile His Asn Glu Val Glu Phe Glu Trp Leu Arg Gln Phe
             370                 375                 380

 tgg ttt caa ggc aat cga tac aga aag tgc act gac tgg tgg tgt caa     1200
 Trp Phe Gln Gly Asn Arg Tyr Arg Lys Cys Thr Asp Trp Trp Cys Gln
         385                 390                 395

 ccc atg gct caa ctg gaa gca ctg tgg aag aag atg gag ggt gtg aca     1248
 Pro Met Ala Gln Leu Glu Ala Leu Trp Lys Lys Met Glu Gly Val Thr
     400                 405                 410

 aat gct gtg ctt cat gaa gtt aaa aga gag ggg ctc ccc gtg gaa caa     1296
 Asn Ala Val Leu His Glu Val Lys Arg Glu Gly Leu Pro Val Glu Gln
 415                 420                 425                 430

 agg aat gaa atc ttg act gcc atc ctt gcc tcg ctc act gca cgc cag     1344
 Arg Asn Glu Ile Leu Thr Ala Ile Leu Ala Ser Leu Thr Ala Arg Gln
                 435                 440                 445

 aac ctg agg aga gaa tgg cat gcc agg tgc cag tca cga att gcc cga     1392
 Asn Leu Arg Arg Glu Trp His Ala Arg Cys Gln Ser Arg Ile Ala Arg
             450                 455                 460

 aca tta cct gct gat cag aag cca gaa tgt cgg cca tac tgg gaa aag     1440
 Thr Leu Pro Ala Asp Gln Lys Pro Glu Cys Arg Pro Tyr Trp Glu Lys
         465                 470                 475

 gat gat gct tcg atg cct ctg ccg ttt gac ctc aca gac atc gtt tca     1488
 Asp Asp Ala Ser Met Pro Leu Pro Phe Asp Leu Thr Asp Ile Val Ser
     480                 485                 490

 gaa ctc aga ggt cag ctt ctg gaa gca aaa ccc tag aagg agcacaagtc     1538
 Glu Leu Arg Gly Gln Leu Leu Glu Ala Lys Pro 
 495                 500                 505

 tcaggcggag gagaaaaaga gatcggcttt tctcctccaa cgttgtcatg ggcttaagca   1598

 agagcagtgg agacttctct tggcccctag attgtagcac ccgggtccca atccaaaaca   1658

 gctaggaaat ggtgcccatg aagttttaaa tgttttaaaa tgaccctgtg ttatagtctg   1718

 atttggtgtt aaacaggacc ttcttccccc aaaattgttc agattataaa atgtgagcca   1778

 ttcagccccc aaggtccagg gcaggcgaca ggaacgagcc cagcgtgtga caaagcctaa   1838

 cctactttcc tctttcccaa gctttttcag agactctgga gtggacccag ccctctgggg   1898

 aaagacagaa cttagagaca tcccagttac tcaccacacc catagt                  1944




      <210> 82
      <211> 709
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (96)..(413)

      <400> 82
 cgaagcagca gcgcaggttg tccccgtttc ccctccccct tcccttctcc ggttgccttc     60

 ccgggcccct tacactccac agtcccggtc ccgcc   atg tcc cag aaa caa gaa     113
                                          Met Ser Gln Lys Gln Glu
                                            1               5

 gaa gag aac cct gcg gag gag acc ggc gag gag aag cag gac acg cag      161
 Glu Glu Asn Pro Ala Glu Glu Thr Gly Glu Glu Lys Gln Asp Thr Gln
              10                  15                  20

 gag aaa gaa ggt att ctg cct gag aga gct gaa gag gca aag cta aag      209
 Glu Lys Glu Gly Ile Leu Pro Glu Arg Ala Glu Glu Ala Lys Leu Lys
          25                  30                  35

 gcc aaa tac cca agc cta gga caa aag cct gga ggc tcc gac ttc ctc      257
 Ala Lys Tyr Pro Ser Leu Gly Gln Lys Pro Gly Gly Ser Asp Phe Leu
      40                  45                  50

 atg aag aga ctc cag aaa ggg gta tgg ggc ata gtc tct tac cct ctt      305
 Met Lys Arg Leu Gln Lys Gly Val Trp Gly Ile Val Ser Tyr Pro Leu
  55                  60                  65                  70

 tct ttg gag cta aag gag gtt ctt cga atg aag tct gta gag gtt cta      353
 Ser Leu Glu Leu Lys Glu Val Leu Arg Met Lys Ser Val Glu Val Leu
                  75                  80                  85

 ctg gat cct ttt ctg gag gtt ttg ttg ttg aac aga agt aga ggc gaa      401
 Leu Asp Pro Phe Leu Glu Val Leu Leu Leu Asn Arg Ser Arg Gly Glu
              90                  95                 100

 ttt gaa att tga aaa gagcaagtca aattaatgta aatccctgat gtggtatcaa      456
 Phe Glu Ile 
         105

 ttccctcctg atttcccatg taggaaatta aggcctaaat tggagcattt gggtgtgtgg    516

 ggaaatgagg gaaagatgtt agaaactgaa atgcagactg cccccaggca tttgcctgtt    576

 tgaatgttgg aggttttagg attgtgcact ttttaagcat tagagataaa ttttgggatg    636

 catcatttca gaagaagatc aaaccatctc tcctacagaa ataaatcctc aacttgaaat    696

 gaaaaaaaaa aaa                                                       709




      <210> 83
      <211> 2480
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (335)..(1984)

      <400> 83
 gcagagcacc gagctgtgtc cgggcggggg agcccgcgtt gtggcagtgg cggcgctccg     60

 aggccgcctg gtgtggtgcg aggagcggca ggcccgggcc gagggcccgt cagggtcgcc    120

 agcagccgct ttcagccact gtgtgtgcgt ccggactctg gagcccagcg gggaagctag    180

 caccagcctg ggccgcacac acgtcctgct gcaccactgc cctgccttcg ggctgctggc    240

 ctcctgcaga caactcttcc tggtgcccac tgccaccacc tggcctggcg tggcccacgt    300

 tctactcatc tggagcccag gcaagggcaa agtg    atg gtg gct gcc cca cgg     352
                                          Met Val Ala Ala Pro Arg
                                            1               5

 ctt ggt ctc tcc tac agt aag agt ctg aat cct gga cga ggg gac aca      400
 Leu Gly Leu Ser Tyr Ser Lys Ser Leu Asn Pro Gly Arg Gly Asp Thr
              10                  15                  20

 tgg gac ttc cgg acc ctg ctc cga ggc ctt cct ggg ttg ctg tcc ccc      448
 Trp Asp Phe Arg Thr Leu Leu Arg Gly Leu Pro Gly Leu Leu Ser Pro
          25                  30                  35

 agg gag cca ctg gct gta cac acc tgg gcc cca act ccc cag ggc ctg      496
 Arg Glu Pro Leu Ala Val His Thr Trp Ala Pro Thr Pro Gln Gly Leu
      40                  45                  50

 ctg ttg ctt gac ttc ggg ggc act gtg agc cta ttg cag tcc cac ggt      544
 Leu Leu Leu Asp Phe Gly Gly Thr Val Ser Leu Leu Gln Ser His Gly
  55                  60                  65                  70

 ggt acg cgg gct gtg ggc acc ctg cag gag gca cct gta ggc ccg tgg      592
 Gly Thr Arg Ala Val Gly Thr Leu Gln Glu Ala Pro Val Gly Pro Trp
                  75                  80                  85

 ggg tct gca gcc cta ggc aca ttt cag ggc act ctg gcc tgt gtg ctg      640
 Gly Ser Ala Ala Leu Gly Thr Phe Gln Gly Thr Leu Ala Cys Val Leu
              90                  95                 100

 ggc tcc aca ttg gaa ctg ctg gac atg ggc agt ggg cag ctg ctg gag      688
 Gly Ser Thr Leu Glu Leu Leu Asp Met Gly Ser Gly Gln Leu Leu Glu
         105                 110                 115

 agg aag gtc cta agt aca gac agg gta cat ctg cta gaa ccg cca gcc      736
 Arg Lys Val Leu Ser Thr Asp Arg Val His Leu Leu Glu Pro Pro Ala
     120                 125                 130

 ccc ggc atg gag gat gag gaa gag ctg gag acc cga ggg aat ctt cgt      784
 Pro Gly Met Glu Asp Glu Glu Glu Leu Glu Thr Arg Gly Asn Leu Arg
 135                 140                 145                 150

 ctg ctt tca gcc ttg ggt ctg ttt tgt gtg ggc tgg gaa gcc cca cag      832
 Leu Leu Ser Ala Leu Gly Leu Phe Cys Val Gly Trp Glu Ala Pro Gln
                 155                 160                 165

 ggt gtt gag ttg cct tca gcc aag gat ctg gtg ttt gag gag gcc tgc      880
 Gly Val Glu Leu Pro Ser Ala Lys Asp Leu Val Phe Glu Glu Ala Cys
             170                 175                 180

 ggg tac tac cag cgg cgg agc ctg cgg ggt gcc cag ctc act cca gaa      928
 Gly Tyr Tyr Gln Arg Arg Ser Leu Arg Gly Ala Gln Leu Thr Pro Glu
         185                 190                 195

 gaa ctg aga cac agc agc aca ttc cgg gca cct cag gct ctg gcc tcc      976
 Glu Leu Arg His Ser Ser Thr Phe Arg Ala Pro Gln Ala Leu Ala Ser
     200                 205                 210

 atc ctc cag ggc cac ctg ccc cca tct gca ctg ctg acc atg ttg agg     1024
 Ile Leu Gln Gly His Leu Pro Pro Ser Ala Leu Leu Thr Met Leu Arg
 215                 220                 225                 230

 acc gag ctt cgg gat tac cga ggc tta gaa cag ctg aag gcc cag ctg     1072
 Thr Glu Leu Arg Asp Tyr Arg Gly Leu Glu Gln Leu Lys Ala Gln Leu
                 235                 240                 245

 gtg gct ggg gat gat gag gag gct ggt tgg act gag ctg gcg gag cag     1120
 Val Ala Gly Asp Asp Glu Glu Ala Gly Trp Thr Glu Leu Ala Glu Gln
             250                 255                 260

 gaa gtg gca cgc ctg ctg agg act gag ttg ata gga gac cag cta gcc     1168
 Glu Val Ala Arg Leu Leu Arg Thr Glu Leu Ile Gly Asp Gln Leu Ala
         265                 270                 275

 cag ctc aac acc gtt ttc caa gcc ctt cct aca gca gcc tgg ggt gcc     1216
 Gln Leu Asn Thr Val Phe Gln Ala Leu Pro Thr Ala Ala Trp Gly Ala
     280                 285                 290

 acc ctc agg gcc ctg cag ctc cag cta gat ggg aat ggc aag ctg agg     1264
 Thr Leu Arg Ala Leu Gln Leu Gln Leu Asp Gly Asn Gly Lys Leu Arg
 295                 300                 305                 310

 tcc caa gca ccc cct gat gtg tgg aag aaa gtg tta ggg gga ata acc     1312
 Ser Gln Ala Pro Pro Asp Val Trp Lys Lys Val Leu Gly Gly Ile Thr
                 315                 320                 325

 gct gga aag gaa ccc ccc aat gga ata ctg ccc ccc ttt gaa ctc ctg     1360
 Ala Gly Lys Glu Pro Pro Asn Gly Ile Leu Pro Pro Phe Glu Leu Leu
             330                 335                 340

 tgc cag tgt ctg tgc cag ctg gag cct cga tgg ctg cca ccc ttt gtg     1408
 Cys Gln Cys Leu Cys Gln Leu Glu Pro Arg Trp Leu Pro Pro Phe Val
         345                 350                 355

 gag ctg gca cag cag cag ggc ggg ccg ggc tgg ggg gca ggg ggc cca     1456
 Glu Leu Ala Gln Gln Gln Gly Gly Pro Gly Trp Gly Ala Gly Gly Pro
     360                 365                 370

 gga ctg ccc ctg tat cgc cga gct ctg gca gtg cta ggt gag gag ggg     1504
 Gly Leu Pro Leu Tyr Arg Arg Ala Leu Ala Val Leu Gly Glu Glu Gly
 375                 380                 385                 390

 acc agg cct gag gct ctg gag cta gag ctg ctc ttg agc agt ggg cgg     1552
 Thr Arg Pro Glu Ala Leu Glu Leu Glu Leu Leu Leu Ser Ser Gly Arg
                 395                 400                 405

 cct aaa gct gtg ctc caa gct gtc ggg cag ctg gtg caa aag gaa caa     1600
 Pro Lys Ala Val Leu Gln Ala Val Gly Gln Leu Val Gln Lys Glu Gln
             410                 415                 420

 tgg gat cgg gct ctg gat gct ggc ctg gcc ctc ggc ccc tcc agt ccc     1648
 Trp Asp Arg Ala Leu Asp Ala Gly Leu Ala Leu Gly Pro Ser Ser Pro
         425                 430                 435

 ctg ctt cga agt gaa atc ttc aaa ctg ctg ctg gcc gag ttt gcc cag     1696
 Leu Leu Arg Ser Glu Ile Phe Lys Leu Leu Leu Ala Glu Phe Ala Gln
     440                 445                 450

 cac cgc cgg ctt gat gct cac ctc ccc ctc ctt tgc cgc ctg tgc cca     1744
 His Arg Arg Leu Asp Ala His Leu Pro Leu Leu Cys Arg Leu Cys Pro
 455                 460                 465                 470

 cca gaa ctg gct cca gct gag ctc ctg ctt cta ctg agg aca tac ctc     1792
 Pro Glu Leu Ala Pro Ala Glu Leu Leu Leu Leu Leu Arg Thr Tyr Leu
                 475                 480                 485

 cca gat gag gtg ggg ccc cca acc cca ttc cct gag cct gga gca gag     1840
 Pro Asp Glu Val Gly Pro Pro Thr Pro Phe Pro Glu Pro Gly Ala Glu
             490                 495                 500

 ccc cct ctc act gtg ggc ttg ctc aaa gcc ctg ctg gag cag act ggg     1888
 Pro Pro Leu Thr Val Gly Leu Leu Lys Ala Leu Leu Glu Gln Thr Gly
         505                 510                 515

 gct caa gga tgg ctg tcg ggc cca gtt cta agc cca tat gag gac atc     1936
 Ala Gln Gly Trp Leu Ser Gly Pro Val Leu Ser Pro Tyr Glu Asp Ile
     520                 525                 530

 cta tgg gac ccc agc act cca ccc ccg act cca cct cgg gac cta tga     1984
 Leu Trp Asp Pro Ser Thr Pro Pro Pro Thr Pro Pro Arg Asp Leu 
 535                 540                 545

 ctacccttca ggcatcagaa cactcagggc ctggaggctt gcttgggact ggaggcttgc   2044

 ttggacagtt cctctgtgtc actgacacag gaaatcattt ctaggacaca gtgatcaggg   2104

 aagggtgcct gggacttgga gggtcccatg tatggacctg tgtatgcaat actgttctgt   2164

 catctggagc tatttttaag atgtgtgtgt taaatatata catagtttaa tatatacaca   2224

 gttgtgtgtt tttaaacagg tacaggtctc agaggatgca ggttatagag ggagtggttg   2284

 gatctggatc ttttggctaa agtccccact tccaatcatg aaaatagtta acatttatga   2344

 gcatttaata gaagccaggc attctactca tctttatata atccctcagc tagcttctca   2404

 tatacccagt ggggaaagta ctgatgttat tcccatttta caggaaatag aagtttagaa   2464

 aaattaaaaa aaaaaa                                                   2480




      <210> 84
      <211> 4739
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (439)..(1770)

      <400> 84
 ctggcgcaga gagtatcctg gaccgccggt gggtggtcgc tagggctggg ccagccgctt     60

 ggaggtccac gcccgccgag cccacgctgg ctggggccgg ggtgcctggc gcgctcggga    120

 ctcgtctcag cagtcgctca ctggtctttg tgtcttctct tcctgcccct ttcccttgcc    180

 tgcctgcctc ctggcctgcc actgatgccc ctgctgcccc gcatgcatgc ctgccgcgga    240

 ctggctgctg cctggctgct gcgctgcttg catgcgtgcg gtgtgttggc gccccatctg    300

 ctacactggg cctgaagaag gaacgaagag gaagctgaat gctgcgcccc cctggcccat    360

 gccgcagcca ctgggcccag acccgccacg gctgcccgcg ccgccagccc atcgccagga    420

 agcaccacag agacctgc  atg gac ggg cat ggg ctt gag aag cag cac cat     471
                      Met Asp Gly His Gly Leu Glu Lys Gln His His
                        1               5                  10

 tcc aga cgc cag ccg ctg ccg gcc gcc gag gtt gag cag cgc cgc cga      519
 Ser Arg Arg Gln Pro Leu Pro Ala Ala Glu Val Glu Gln Arg Arg Arg
              15                  20                  25

 ccc ggg cat ctg ccc ccc ggc tgc tgg agc atg ctg ctg ctg ctg ctg      567
 Pro Gly His Leu Pro Pro Gly Cys Trp Ser Met Leu Leu Leu Leu Leu
          30                  35                  40

 ttc agc ctc ggg ctg ctc cac gca ggt gac tgc caa cag cca gcc caa      615
 Phe Ser Leu Gly Leu Leu His Ala Gly Asp Cys Gln Gln Pro Ala Gln
      45                  50                  55

 tgt cga atc cag aaa tgc acc acg gac ttc gtg tcc ctg act tct cac      663
 Cys Arg Ile Gln Lys Cys Thr Thr Asp Phe Val Ser Leu Thr Ser His
  60                  65                  70                  75

 ctg aac tct gcc gtt gac ggc ttt gac tct gag ttt tgc aag gcc ttg      711
 Leu Asn Ser Ala Val Asp Gly Phe Asp Ser Glu Phe Cys Lys Ala Leu
                  80                  85                  90

 cgt gcc tat gct ggc tgc acc cag cga act tca aaa gcc tgc cgt ggc      759
 Arg Ala Tyr Ala Gly Cys Thr Gln Arg Thr Ser Lys Ala Cys Arg Gly
              95                 100                 105

 aac ctg gta tac cat tct gcc gtg ttg ggt atc agt gac ctc atg agc      807
 Asn Leu Val Tyr His Ser Ala Val Leu Gly Ile Ser Asp Leu Met Ser
         110                 115                 120

 cag agg aat tgt tcc aag gat gga ccc aca tcc tct acc aac ccc gaa      855
 Gln Arg Asn Cys Ser Lys Asp Gly Pro Thr Ser Ser Thr Asn Pro Glu
     125                 130                 135

 gtg acc cat gat cct tgc aac tat cac agc cac gct gga gcc agg gaa      903
 Val Thr His Asp Pro Cys Asn Tyr His Ser His Ala Gly Ala Arg Glu
 140                 145                 150                 155

 cac agg aga ggg gac cag aac cct ccc agt tac ctt ttt tgt ggc ttg      951
 His Arg Arg Gly Asp Gln Asn Pro Pro Ser Tyr Leu Phe Cys Gly Leu
                 160                 165                 170

 ttt gga gat cct cac ctc aga act ttc aag gat aac ttc caa aca tgc      999
 Phe Gly Asp Pro His Leu Arg Thr Phe Lys Asp Asn Phe Gln Thr Cys
             175                 180                 185

 aaa gta gaa ggg gcc tgg cca ctc ata gat aat aat tat ctt tca gtt     1047
 Lys Val Glu Gly Ala Trp Pro Leu Ile Asp Asn Asn Tyr Leu Ser Val
         190                 195                 200

 caa gtg aca aac gta cct gtg gtc cct gga tcc agt gct act gct aca     1095
 Gln Val Thr Asn Val Pro Val Val Pro Gly Ser Ser Ala Thr Ala Thr
     205                 210                 215

 aat aag atc act att atc ttc aaa gcc cac cat gag tgt aca gat cag     1143
 Asn Lys Ile Thr Ile Ile Phe Lys Ala His His Glu Cys Thr Asp Gln
 220                 225                 230                 235

 aaa gtc tac caa gct gtg aca gat gac ctg ccg gcc gcc ttt gtg gat     1191
 Lys Val Tyr Gln Ala Val Thr Asp Asp Leu Pro Ala Ala Phe Val Asp
                 240                 245                 250

 ggc acc acc agt ggt ggg gac agc gat gcc aag agc ctg cgt atc gtg     1239
 Gly Thr Thr Ser Gly Gly Asp Ser Asp Ala Lys Ser Leu Arg Ile Val
             255                 260                 265

 gaa agg gag agt ggc cac tat gtg gag atg cac gcc cgc tat ata ggg     1287
 Glu Arg Glu Ser Gly His Tyr Val Glu Met His Ala Arg Tyr Ile Gly
         270                 275                 280

 acc aca gtg ttt gtg cgg cag gtg ggt cgc tac ctg acc ctt gcc atc     1335
 Thr Thr Val Phe Val Arg Gln Val Gly Arg Tyr Leu Thr Leu Ala Ile
     285                 290                 295

 cgt atg cct gaa gac ctg gcc atg tcc tac gag gag agc cag gac ctg     1383
 Arg Met Pro Glu Asp Leu Ala Met Ser Tyr Glu Glu Ser Gln Asp Leu
 300                 305                 310                 315

 cag ctg tgc gtg aac ggc tgc ccc ctg agt gaa cgc atc gat gac ggg     1431
 Gln Leu Cys Val Asn Gly Cys Pro Leu Ser Glu Arg Ile Asp Asp Gly
                 320                 325                 330

 cag ggc cag gtg tct gcc atc ctg gga cac agc ctg cct cgc acc tcc     1479
 Gln Gly Gln Val Ser Ala Ile Leu Gly His Ser Leu Pro Arg Thr Ser
             335                 340                 345

 ttg gtg cag gcc tgg cct ggc tac aca ctg gag act gcc aac act caa     1527
 Leu Val Gln Ala Trp Pro Gly Tyr Thr Leu Glu Thr Ala Asn Thr Gln
         350                 355                 360

 tgc cat gag aag atg cca gtg aag gac atc tat ttc cag tcc tgt gtc     1575
 Cys His Glu Lys Met Pro Val Lys Asp Ile Tyr Phe Gln Ser Cys Val
     365                 370                 375

 ttc gac ctg ctc acc act ggt gat gcc aac ttt act gcc gca gcc cac     1623
 Phe Asp Leu Leu Thr Thr Gly Asp Ala Asn Phe Thr Ala Ala Ala His
 380                 385                 390                 395

 agt gcc ttg gag gat gtg gag gcc ctg cac cca agg aag gaa cgc tgg     1671
 Ser Ala Leu Glu Asp Val Glu Ala Leu His Pro Arg Lys Glu Arg Trp
                 400                 405                 410

 cac att ttc ccc agc agt ggc aat ggg act ccc cgt gga ggc agt gat     1719
 His Ile Phe Pro Ser Ser Gly Asn Gly Thr Pro Arg Gly Gly Ser Asp
             415                 420                 425

 ttg tct gtc agt cta gga ctc acc tgc ttg atc ctt atc gtg ttt ttg     1767
 Leu Ser Val Ser Leu Gly Leu Thr Cys Leu Ile Leu Ile Val Phe Leu
         430                 435                 440

 tag gggt tgtcttttgt tttggttttt tattttttgt ctataacaaa attttaaaat     1824
 


 atatattgtc ataatatatt gagtaaaaga gtatatatgt atataccatg tatatgacag   1884

 gatgtttgtc ctgggacacc caccagattg tacatactgt gtttggctgt tttcacatat   1944

 gttggatgta gtgttctttg attgtatcaa ttttgttttg cagttctgtg aaatgtttta   2004

 taatgtccct gcccagggac ctgttagaaa gcactttatt ttttatatat taaatattta   2064

 tgtgtgtgct tggttgatat gtatagtaca tatacacaga catccatatg cagcgtttcc   2124

 tttgaaggtg accagttgtt tgtagctatt cttggctgta ccttcctgcc ctttcccatt   2184

 gctactgatt tgccacggtg tgcagctttt actcgccacc ttccggtgga gctgcctcgt   2244

 tcctttgaac tatgccctca cccttctgcc ctcacttgat ttgaaagggt cgttaactct   2304

 cccttacagg tgctttgact cttaaacgct gatcttaaga agctctcttc atctaagagc   2364

 tgttactttt tcagaagggg gggtattatt ggtattctga ttactctcaa ttctaattgt   2424

 tatatatttg agcccataca gtgtattagg ttgaaccata gaaactgcta ttctcgtagg   2484

 tcaaaagggt ctagtgatgg aagttttgta gataagtacc aggcatctca gtaactccta   2544

 gactttttct catcccatgc cccgttttaa attgtcagtt ttccctctga ctcttctgtg   2604

 ttaaaacatg aaactataaa tttagtaatt atcatgcctt gctcttttta atctatatga   2664

 ctgatgcaag cccctcttct taaccgtttc ttggctttga gcccagaaac acagctctcc   2724

 ctgtctccaa ctccagtaag ccctcctcag cctcacctta cgaatccaaa gaactggggt   2784

 ttgttaggtt ctttctctaa tgtagaggcc cagatcccat cacaaagttt ttcattcttc   2844

 cttgtccacc atgatcttca tcacagtctt tgatatgtct gcatgcaaag tggaacagag   2904

 ttgggcggca atgacagaag agcttccttg gcctgactcg gtgtgcggcc acttcggcac   2964

 tgcttaatcc agatattctt gttaactaag cattgtgctt cccaggtggt ctgaagtcag   3024

 gtactctctc tctcaacacc tgtagttgaa tatgatttgg tcagttgctc gttgtaactt   3084

 ggagaaattc ctataaagta agatctcctt gcctcttcca tccattgttg gcaccccctt   3144

 gcaaaaggaa aagaacagca aaagtcagga gcagtaatct gagaaagtta actccaggat   3204

 aggtaggttt ctattgttat agctagatgt aaatctttag ttccaagaag tgatagagtt   3264

 tctgctttaa taatttgttg ataagtttac ataaacagaa ataaaagata ctatctttac   3324

 cgtagtagtt caggccaaga ttatgcttag ttttagttct ccaggtagtt acttttgcca   3384

 tgtcctattg atcagtgaca ctgccagagg cccataccgg caagaggaag aggacgtcat   3444

 tttgtaaagt ttaacttctt agcgaactga tgtgccaccc agtcacagag tggagttgtg   3504

 aattcatgta gaggtggcaa acctctacct tgtgttgatg agagaataat cttgggcagt   3564

 ctgggaaaat aaggaaggca tctccttctt actcatggag attcaactat agagagttga   3624

 aacctaaacc cgccttcctt ttatagaagc tggactagag acggactgac catcagctct   3684

 gaactgtggc tttttttgtt cacctatgat gccatgtacc aaattcagaa gctatcgtta   3744

 ataatttgtt ttataattga gtagtacaag cgaggaaaaa atacggagga taaccactat   3804

 ttttgtgcaa ataatatgaa agtgaagtaa aagcaataga agaaatttct ataggatctg   3864

 ggtttagagt gtgtatcatt aataaatata cctttgctct tttcagggaa aataacaacc   3924

 acccttactg atagttggga aaagaagatt gggttatttt gccatatcat ttagctggaa   3984

 gtgacattta aaagcaccct gcatcactag taatagtgta ttttgctatt ctgcccttgt   4044

 aatcggtgtc cctgtaaaac aatccccaca gattactttc agaaatagat gtatttctct   4104

 acgtaagggc caggtttatt ttctcctttt ttgagatttc tagaaaaaat gctgcttgca   4164

 catgttggtt cttgaaacct tagctagaag aatttcaggt cataccaaca tgtggatagg   4224

 ctatagctgt tcagaggtct cctgggggag cttaaaacgg gggaaacact ggttttcaca   4284

 gatgctccac atggctgtct ttaaaagact caaaactttt ttttgtcctc tttgttatgc   4344

 ttggaagctc cccccccccc aacagtgtgt cgagtctttg caaagaaacc tttagatgtg   4404

 gttcatagat atatgaatac gtatctgtgt aaaacagtga gtgtgcagtg tgtaaatact   4464

 ttaaattatt atgctagaaa aataaagtta cataccttgc acactcactg ttttacacag   4524

 atacgtattc atatatctat gaaccacatc taaaggtttc tttgcaaaga ctcgacacac   4584

 tgtggggggg ggggggagct tccaagcata acaaagagga caaaaaaaag ttttgagtct   4644

 tttaaagaca gccatgtgga gcatctgtga aaaccagttg tttcccccgt tttaagctcc   4704

 cccaggaggt cgaccggccg cgaatttagt agtag                              4739




      <210> 85
      <211> 408
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (145)..(357)

      <400> 85
 cggcacgagg acagtggcgg aggacggcgc tcgctagtct cccaggtcgc ggtacacggc     60

 gagaacgggc ggggcggtct cggctgcgtc cgggcgatcc agtgcttagt tccgtcatat    120

 ccctctccac gacctcggtc gagc   atg ttc acc agg gcc cag gtg aga cgg     171
                              Met Phe Thr Arg Ala Gln Val Arg Arg
                                1               5

 att ctg cag cgg gtg ccc ggg aag cag cga ttt ggc atc tac cgg ttc      219
 Ile Leu Gln Arg Val Pro Gly Lys Gln Arg Phe Gly Ile Tyr Arg Phe
  10                  15                  20                  25

 ctg ccc ttc ttt ttt gtc ctg gga gga acg atg gag tgg atc atg att      267
 Leu Pro Phe Phe Phe Val Leu Gly Gly Thr Met Glu Trp Ile Met Ile
                  30                  35                  40

 aaa gtg cgc gtg ggc cag gag acc ttc tat gat gtc tac cgt aga aaa      315
 Lys Val Arg Val Gly Gln Glu Thr Phe Tyr Asp Val Tyr Arg Arg Lys
              45                  50                  55

 gcc tca gaa aga cag tat cag aga agg ctg gaa gat gaa tga gactgaa      364
 Ala Ser Glu Arg Gln Tyr Gln Arg Arg Leu Glu Asp Glu 
          60                  65                  70

 cttcagcagt caataaagtc aatatgaatt tttaaaaaaa aaaa                     408




      <210> 86
      <211> 1217
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(657)

      <400> 86
 atcgtctttt tactttattt agaaacctgt ttggaggtt   atg gat gat aaa ccc      54
                                              Met Asp Asp Lys Pro
                                                1               5

 aat cct gaa gcc cta agt gac agt tca gag cgt ctt ttc tcc ttt ggc      102
 Asn Pro Glu Ala Leu Ser Asp Ser Ser Glu Arg Leu Phe Ser Phe Gly
                  10                  15                  20

 gtc atc gca gat gtt caa ttt gca gac tta gaa gat ggc ttt aat ttc      150
 Val Ile Ala Asp Val Gln Phe Ala Asp Leu Glu Asp Gly Phe Asn Phe
              25                  30                  35

 caa gga acc agg cgg cga tac tac aga cat agt ctt ctt cac tta cag      198
 Gln Gly Thr Arg Arg Arg Tyr Tyr Arg His Ser Leu Leu His Leu Gln
          40                  45                  50

 ggt gcc att gaa gac tgg aat aat gaa agc agc atg ccc tgt tgt gtc      246
 Gly Ala Ile Glu Asp Trp Asn Asn Glu Ser Ser Met Pro Cys Cys Val
      55                  60                  65

 ctt cag ctt gga gat atc atc gat gga tat aat gca cag tat aat gca      294
 Leu Gln Leu Gly Asp Ile Ile Asp Gly Tyr Asn Ala Gln Tyr Asn Ala
  70                  75                  80                  85

 tcc aaa aag tcc cta gaa ctt gtt atg gac atg ttc aag agg ctt aaa      342
 Ser Lys Lys Ser Leu Glu Leu Val Met Asp Met Phe Lys Arg Leu Lys
                  90                  95                 100

 gtt cca gtt cat cat aca tgg gga aac cat gaa ttc tat aac ttc agt      390
 Val Pro Val His His Thr Trp Gly Asn His Glu Phe Tyr Asn Phe Ser
             105                 110                 115

 aga gag tat tta aca cac tct aaa ctt aac act aag ttt cta gaa gat      438
 Arg Glu Tyr Leu Thr His Ser Lys Leu Asn Thr Lys Phe Leu Glu Asp
         120                 125                 130

 cag att gta cat cat cct gag acc atg cct tca gaa gat tat tat gct      486
 Gln Ile Val His His Pro Glu Thr Met Pro Ser Glu Asp Tyr Tyr Ala
     135                 140                 145

 tat cat ttt gta cca ttc cct aaa ttc cgg ttc att tta ctt gat gca      534
 Tyr His Phe Val Pro Phe Pro Lys Phe Arg Phe Ile Leu Leu Asp Ala
 150                 155                 160                 165

 tat gac ttg agt gtc ttg ggc gtg gat cag tct tct cca aaa tac gag      582
 Tyr Asp Leu Ser Val Leu Gly Val Asp Gln Ser Ser Pro Lys Tyr Glu
                 170                 175                 180

 cag tgt atg aag ata ttg agg gag cac aat cca aat acg gaa ctg aat      630
 Gln Cys Met Lys Ile Leu Arg Glu His Asn Pro Asn Thr Glu Leu Asn
             185                 190                 195

 agt cct caa ggt gaa tta ttc ctt tga gctga gaatctaata gattgtcttt      682
 Ser Pro Gln Gly Glu Leu Phe Leu 
         200                 205

 aaattcttca gctacctttt attcagcagg aagatggaca attaaggact ttctgagccc    742

 cagtttgtcc agtttaatgg aggattcagc caagaacagc taaactggtt gaatgaagtg    802

 ctaacattct ctgacacaaa ccaagaaaag gtggtgattg tgagccatct tcccatttac    862

 ccggacgcct ctgacaatgt gtgcctggcc tggaactaca gagatgccct ggcagtcatt    922

 tggtctcatg agtgtgtggt gtgtttcttt gctggtcaca cccatgatgg tggctactct    982

 gaggatcctt ttggtgtata ccacgtcaac ctagaaggag ttattgaaac agctccagac   1042

 agccaagcct ttggcacagt tcatgtctat cctgacaaaa tgatgttgaa agggagaggc   1102

 agagttccag atagaattat gaattacaag aaaggaagag ccttccattg ttagtctaat   1162

 ttattttaac ttgatagaaa atgagctttg tgtttgtccc tcctaaacaa aaaaa        1217




      <210> 87
      <211> 843
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (346)..(792)

      <400> 87
 gaagcctgcg cagcatctcc gagagggcgc ctggagcgag catggagagg ccatccgcag     60

 aggagcgcgt gctcgtacgg gacttccagc gcctgcttgg tgtggctgtc cgccaggacc    120

 ccaccttgtc tccgtttgtc tgcaagagct gccacgccca gttctaccag tgccacagcc    180

 ttctcaagtc cttcctgcag agggtcaacg cctccccggc tggtcgccgg aagccttgtg    240

 caaaggtcgg tgcccagccc ccaacagggg cagaggaggg agcgtgtctg gtggatctga    300

 tcacatccag cccccagtgc ctgcacggct tggtggggtg ggtgc    atg gac atg     354
                                                      Met Asp Met
                                                        1

 cgg cca gct gcg ggg ccc tgc ccc acc ttc aga gga cac tgt cct ccg      402
 Arg Pro Ala Ala Gly Pro Cys Pro Thr Phe Arg Gly His Cys Pro Pro
       5                  10                  15

 agt act gcg gcg tca tcc agg tcg tgt ggg gct gcg acc agg gcc acg      450
 Ser Thr Ala Ala Ser Ser Arg Ser Cys Gly Ala Ala Thr Arg Ala Thr
  20                  25                  30                  35

 act aca cca tgg ata cca gct cca gct gca agg cct tct tgc tgg aca      498
 Thr Thr Pro Trp Ile Pro Ala Pro Ala Ala Arg Pro Ser Cys Trp Thr
                  40                  45                  50

 gtg cgc tgg cag tca agt ggc cat ggg aca aag aga cgg cgc cac ggc      546
 Val Arg Trp Gln Ser Ser Gly His Gly Thr Lys Arg Arg Arg His Gly
              55                  60                  65

 tgc ccc agc acc gag ggt gga acc ctg ggg atg ccc ctc aga cct ccc      594
 Cys Pro Ser Thr Glu Gly Gly Thr Leu Gly Met Pro Leu Arg Pro Pro
          70                  75                  80

 agg gta gag gga cag gga ccc cag ttg ggg ctg aga cca aga ccc tgc      642
 Arg Val Glu Gly Gln Gly Pro Gln Leu Gly Leu Arg Pro Arg Pro Cys
      85                  90                  95

 cca gca cgg atg tgg ccc agc ctc ctt cgg aca gcg acg cgg tgg ggc      690
 Pro Ala Arg Met Trp Pro Ser Leu Leu Arg Thr Ala Thr Arg Trp Gly
 100                 105                 110                 115

 cca ggt cgg gct tcc cac ctc agc caa gcc tgc ccc ttt gca ggg ccc      738
 Pro Gly Arg Ala Ser His Leu Ser Gln Ala Cys Pro Phe Ala Gly Pro
                 120                 125                 130

 cag ggc agt tgg gtg aga agc agc ttc cat ctt caa cct cgg atg atc      786
 Gln Gly Ser Trp Val Arg Ser Ser Phe His Leu Gln Pro Arg Met Ile
             135                 140                 145

 ggg taa aagacgagtt cagtgacctt tctgagggag acgtcttgag tgaagatgaa       842
 Gly 


 a                                                                    843




      <210> 88
      <211> 791
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (564)..(740)

      <400> 88
 acaaaaacaa aatcaaatac aaaacaattt acattttata ttaactggat gttaaatgtg     60

 ggttctttac atttaccaga atttctgcca aggtcctaat ggccccaaat aataggtgct    120

 acattatcaa gcagatatat caagagattg tgataatgtt aatgaaaccc ctttgctcat    180

 cactcatttc caaaatttat attttcaaag ggaattttgt acagagttcc taaaaaaagg    240

 gatcatgatg ccagtgtatt gcctcactga ttgctaaatg aagaggacta tactgaagca    300

 ttcaaagaac gtgatgtgcc tctggggcaa ctgaaggatt gctatctgac ttatgcattt    360

 aaaaccttca aagtggaagt ttgtctggaa tggcttaggc aaacagactg ggttggattg    420

 agaattgaat gtatacataa aatttggttt ggtcagatga gaacaccaaa tgtggtagct    480

 agctcacctt tatttatgag atttttattg ggttgatttg tcttgaaaga atcaaatcta    540

 agagaaatgt ttggaatggc tag    atg atc cta aca gaa gaa atc tta cag     590
                              Met Ile Leu Thr Glu Glu Ile Leu Gln
                                1               5

 gtc ttt act gct aaa cct aag gag atg aga gta aac agt aag tgg cca      638
 Val Phe Thr Ala Lys Pro Lys Glu Met Arg Val Asn Ser Lys Trp Pro
  10                  15                  20                  25

 act caa aga agc atg gac tat gtt gaa aca tgg act ata gct gca att      686
 Thr Gln Arg Ser Met Asp Tyr Val Glu Thr Trp Thr Ile Ala Ala Ile
                  30                  35                  40

 tcc cag tgg tgc agt ttt caa gcg ctt tac ccc agg aga gaa aaa aat      734
 Ser Gln Trp Cys Ser Phe Gln Ala Leu Tyr Pro Arg Arg Glu Lys Asn
              45                  50                  55

 aaa taa atgaaaagta gccatttcac cattcagagg atagatactg ttgcccagtg       790
 Lys 


 a                                                                    791




      <210> 89
      <211> 1655
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(1655)

      <400> 89
 ctcccgtccc caggccacac agattctcct caagagagcc ctataaggac attggtaaa      59                                                                 
 atg tca ctg cct tca gga cac act acg ggt cac act gat caa gtt gtt      107
 Met Ser Leu Pro Ser Gly His Thr Thr Gly His Thr Asp Gln Val Val
   1               5                  10                  15

 caa aga aga gca aga tgt tgg gat att tac caa agg aga ttt agc agt      155
 Gln Arg Arg Ala Arg Cys Trp Asp Ile Tyr Gln Arg Arg Phe Ser Ser
              20                  25                  30

 agg tct gaa cct gtc aat cct ggc atg cat tct tca tcc cat cag cag      203
 Arg Ser Glu Pro Val Asn Pro Gly Met His Ser Ser Ser His Gln Gln
          35                  40                  45

 caa gat gga gat gca gca atg cat ggt gcc cac atg gac tct cca gta      251
 Gln Asp Gly Asp Ala Ala Met His Gly Ala His Met Asp Ser Pro Val
      50                  55                  60

 aga tac act ccc tat act att tca ccc tat aat cgg aaa ggc agt ttt      299
 Arg Tyr Thr Pro Tyr Thr Ile Ser Pro Tyr Asn Arg Lys Gly Ser Phe
  65                  70                  75                  80

 cgt aaa caa gac caa acc cac gtt aac atg gag aga gag caa aaa cct      347
 Arg Lys Gln Asp Gln Thr His Val Asn Met Glu Arg Glu Gln Lys Pro
                  85                  90                  95

 cca gag aga aga atg gag ggg aac atg ccg gat ggg acc tta ggg agc      395
 Pro Glu Arg Arg Met Glu Gly Asn Met Pro Asp Gly Thr Leu Gly Ser
             100                 105                 110

 tgg ttc aag atc aca gtt ccc ttt ggc ata aaa tac aat gag aag tgg      443
 Trp Phe Lys Ile Thr Val Pro Phe Gly Ile Lys Tyr Asn Glu Lys Trp
         115                 120                 125

 ctg ctg aat ttg att cag aat gaa tgc agt gta ccc ttc gtc cca gtt      491
 Leu Leu Asn Leu Ile Gln Asn Glu Cys Ser Val Pro Phe Val Pro Val
     130                 135                 140

 gag ttt cac tat gaa aac atg cat gcc agc ttc ttt gtg gag aat gcc      539
 Glu Phe His Tyr Glu Asn Met His Ala Ser Phe Phe Val Glu Asn Ala
 145                 150                 155                 160

 agc atc gcc tat gca ctg aag aat gtc agt ggc aag att tgg gat gag      587
 Ser Ile Ala Tyr Ala Leu Lys Asn Val Ser Gly Lys Ile Trp Asp Glu
                 165                 170                 175

 gat aat gaa aag ata tca atc ttt gtc aac cct gct ggc ata ccc cac      635
 Asp Asn Glu Lys Ile Ser Ile Phe Val Asn Pro Ala Gly Ile Pro His
             180                 185                 190

 ttt gtg cac agg gag ctg aag tca gaa aag gtg gag cag ata aag ctg      683
 Phe Val His Arg Glu Leu Lys Ser Glu Lys Val Glu Gln Ile Lys Leu
         195                 200                 205

 gcc atg aac caa cag tgt gat gtc tcc cag gaa gct ctt gat atc cag      731
 Ala Met Asn Gln Gln Cys Asp Val Ser Gln Glu Ala Leu Asp Ile Gln
     210                 215                 220

 aga ctc cca ttt tac cca gac atg gtg aac cgt gat act aag atg gca      779
 Arg Leu Pro Phe Tyr Pro Asp Met Val Asn Arg Asp Thr Lys Met Ala
 225                 230                 235                 240

 tcg aat cct aga aag tgc atg gct gcc tcc ctg gac gtc cat gaa gag      827
 Ser Asn Pro Arg Lys Cys Met Ala Ala Ser Leu Asp Val His Glu Glu
                 245                 250                 255

 aac ata cct aca gtg atg tct gca ggg gag atg gac aag tgg aaa ggg      875
 Asn Ile Pro Thr Val Met Ser Ala Gly Glu Met Asp Lys Trp Lys Gly
             260                 265                 270

 ata gag cca gga gag aag tgt gcg gac aga agc cca gtg tgc acg acc      923
 Ile Glu Pro Gly Glu Lys Cys Ala Asp Arg Ser Pro Val Cys Thr Thr
         275                 280                 285

 ttc tcg gat acc tcc agc aac ata aac tcc atc ctg gaa ttg ttc ccc      971
 Phe Ser Asp Thr Ser Ser Asn Ile Asn Ser Ile Leu Glu Leu Phe Pro
     290                 295                 300

 aaa tta tta tgc ctg gat ggc cag cag tca ccc aga gca act tta tgt     1019
 Lys Leu Leu Cys Leu Asp Gly Gln Gln Ser Pro Arg Ala Thr Leu Cys
 305                 310                 315                 320

 ggt act gaa gcc cac aag agg tta cca acc tgt aag gga agc ttc ttt     1067
 Gly Thr Glu Ala His Lys Arg Leu Pro Thr Cys Lys Gly Ser Phe Phe
                 325                 330                 335

 gga tct gag atg ttg aag aat ctg gtc ctg caa ttc ctg cag cag tat     1115
 Gly Ser Glu Met Leu Lys Asn Leu Val Leu Gln Phe Leu Gln Gln Tyr
             340                 345                 350

 tac ttg atc tat gac tct gga gat cga cag ggt ctc ctt agt gct tac     1163
 Tyr Leu Ile Tyr Asp Ser Gly Asp Arg Gln Gly Leu Leu Ser Ala Tyr
         355                 360                 365

 cac gat gag gcc tgc ttc tcc ctg agc att ccc ttc aat cct gag gac     1211
 His Asp Glu Ala Cys Phe Ser Leu Ser Ile Pro Phe Asn Pro Glu Asp
     370                 375                 380

 tca gcc ccg agc agc ttc tgc aag ttc ttc aag gat agc agg aat ata     1259
 Ser Ala Pro Ser Ser Phe Cys Lys Phe Phe Lys Asp Ser Arg Asn Ile
 385                 390                 395                 400

 aaa att ctc aag gac ccc tac ctt cgg ggg gag ctg ctg aag cac aca     1307
 Lys Ile Leu Lys Asp Pro Tyr Leu Arg Gly Glu Leu Leu Lys His Thr
                 405                 410                 415

 aaa ctt gat att gtg gac tcc ctc agt gcg ttg cct aaa act cag cat     1355
 Lys Leu Asp Ile Val Asp Ser Leu Ser Ala Leu Pro Lys Thr Gln His
             420                 425                 430

 gac ctc agc tcc ttc ctg gtg gac atg tgg tac cag acg gaa tgg atg     1403
 Asp Leu Ser Ser Phe Leu Val Asp Met Trp Tyr Gln Thr Glu Trp Met
         435                 440                 445

 ctc tgc ttt tct gtc aac ggg gtg ttc aag gaa gtg gaa gga cag tct     1451
 Leu Cys Phe Ser Val Asn Gly Val Phe Lys Glu Val Glu Gly Gln Ser
     450                 455                 460

 cag ggt tct gtt ctc gcc ttc acc cgg acc ttc att gct acc cct ggc     1499
 Gln Gly Ser Val Leu Ala Phe Thr Arg Thr Phe Ile Ala Thr Pro Gly
 465                 470                 475                 480

 agc agt tcc agt ctg tgc atc gtg aat gac aag ctc ttt gtg cgg gat     1547
 Ser Ser Ser Ser Leu Cys Ile Val Asn Asp Lys Leu Phe Val Arg Asp
                 485                 490                 495

 acc agc cac caa ggg acc cag agt gcc ttg ttc acc cta gtg ccc aca     1595
 Thr Ser His Gln Gly Thr Gln Ser Ala Leu Phe Thr Leu Val Pro Thr
             500                 505                 510

 gcc ttc tcc agc tcc gtg cct gcc ttc tcc cag gag cag cag aaa atg     1643
 Ala Phe Ser Ser Ser Val Pro Ala Phe Ser Gln Glu Gln Gln Lys Met
         515                 520                 525

 ctg cct tcg taa                                                     1655
 Leu Pro Ser 
     530





      <210> 90
      <211> 1848
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (19)..(399)

      <400> 90
 taatgaacca aaaaattt  atg ttg ggt ggt ggg atg aaa tta aag aat aag      51
                      Met Leu Gly Gly Gly Met Lys Leu Lys Asn Lys
                        1               5                  10

 tca act gac ttc aca aaa ctg ctg agc aga gga gcc act att tac agc       99
 Ser Thr Asp Phe Thr Lys Leu Leu Ser Arg Gly Ala Thr Ile Tyr Ser
              15                  20                  25

 aag cag ctc ttc cca cca agt ctc aca cat aca cca aca ttt act ggg      147
 Lys Gln Leu Phe Pro Pro Ser Leu Thr His Thr Pro Thr Phe Thr Gly
          30                  35                  40

 gcc acc atc tta tta ata atc tac cca tgc ata cag cat tcc ttg aac      195
 Ala Thr Ile Leu Leu Ile Ile Tyr Pro Cys Ile Gln His Ser Leu Asn
      45                  50                  55

 aaa gtg gga cct aac cct gaa agg gca ccc aaa tat tac cca cgt tac      243
 Lys Val Gly Pro Asn Pro Glu Arg Ala Pro Lys Tyr Tyr Pro Arg Tyr
  60                  65                  70                  75

 act ctc tat ggg agg gct tta tcc act agc cct ttc ctc aaa gaa aga      291
 Thr Leu Tyr Gly Arg Ala Leu Ser Thr Ser Pro Phe Leu Lys Glu Arg
                  80                  85                  90

 aaa ata cgt cca att tct cag act aaa gaa acc agg tca agt caa cag      339
 Lys Ile Arg Pro Ile Ser Gln Thr Lys Glu Thr Arg Ser Ser Gln Gln
              95                 100                 105

 gag aag aga agg gaa agg caa aaa gat cca acc ctg acg cac aag aat      387
 Glu Lys Arg Arg Glu Arg Gln Lys Asp Pro Thr Leu Thr His Lys Asn
         110                 115                 120

 gac tca cat tag acc gatgataaaa accaaagaag cacaaatcac tgcctgtcac      442
 Asp Ser His 
     125

 ttaacgggaa gatacctgct aaagctttac tctgtatttt ctcaacctct ccttatttcc    502

 ttactagatc caaaggcata caagacaagc aggaaatata taaggaactc cattatggca    562

 gataaggagg cacgtcaggc aatgacacac cattcctagt aactccattt cataaaggca    622

 ctgatctgtc acccactgat ccccagggct gattaaaggc aatgagttct gagaccaatt    682

 actagaggta tctacagaga ctgtggacca tttctgaaac ctgtcccaca aaaagacaaa    742

 agattttctt ggcaaaatat ttctatatta ttaatagtaa aaacaaccaa gattcaggtg    802

 atagcagctt tggctgatca ggacaactta aaagattttg cagatgagct ggcaaaggtc    862

 caagccccaa ccaaggggat tcttcgatcg tgcaagtcct agggacactg tgctcagttt    922

 atcttcctag gacaaggtac tcattaccca aatgttcaga ctcctgacct ttgccaagtg    982

 agtcatatat cctatctcta tatagatacc acaaaaggag cggaaaaaac tgccatacaa   1042

 gccaattccc taggctgaag gcagaaatta cttaaatccc attctgacat ctttctgctt   1102

 tgagttttaa gagaagtttt ctttaaaaca actagtctgt tcctatctta cagataatgt   1162

 gactcttgtg atgttttcct ttggccacca ggaatccctg agccaaatgt tacaggccaa   1222

 atctagcaac tggattgaac ttaaagattc agtgatgata tctgaagagt cttagcgttt   1282

 gtgtcgtgtt tcctaaaaca aagactccat cataagccat gtgaattcct acttcaggac   1342

 ggacaagagt cagaagtggt aatacaggga atggcataag tgattttccc ttgacactac   1402

 agatgcgttc tgaaccatat tttatgacac ctgacaaagc agaatttgtc aagccttgtt   1462

 taagagtccc agttggagca cccagttgga aaccccattt gccattcaat tacccataac   1522

 tgtcaatagt gttgatttta caatgtgtgg ttttgaaata gatctgcaca aattactgtg   1582

 ccaggcacca agaaatggaa atcaaaataa atctgaggtt atatgaaata aatatgcaat   1642

 agcaaaaaca agttttttaa ataactgcct ttgccttttg ttttaattca tctaacttaa   1702

 tttcaggggc agaaaaacaa gtcaagttta caatgacttt caggctgtta gaccctaata   1762

 ctctaagttg tttttttcca ggattttgct tttcattcaa caacaaattg tttagcaact   1822

 aataactggt ctgaattctt tctgcc                                        1848




      <210> 91
      <211> 900
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (635)..(856)

      <400> 91
 aaggagattc ggcagaggct ccttttcaaa agcctttaca tgattcagaa attgctaaac     60

 agggtaacaa gaaagaaatc tttgcatttg tttgtattaa gtacatgttg acctcttaaa    120

 aataaacaga tgagcatgtt gtagttctct gatctgaatg tgcaaaccaa aaaaaacttc    180

 gtagatattt ctggttttgg tttaaacttg agccagaaaa ataatttgta aattgaggta    240

 cttcatcagt aaattgaaaa acattttcat aaatttggaa atttagaatt gggcgttttt    300

 ttctagacat ggtgtctacc attgttcttt tattctagct aacccttttt gtgtttgtgg    360

 agttaatgct tggtttttct tcctatcatc ttattttcat ttaagtcttt tgaattctgc    420

 ctagcacata cctacatttg ttctttggat tgtatgagtt tctttctgaa ttctcctatt    480

 ttttttcttc cttgagcttt accttaaaaa caaaattttc ctatctctca tcttttttct    540

 tccttttctt ctttttcaca ttgcatgatg acctcccatt agatatatag atttatctct    600

 gcttctgctt ttctccaagt gtagaattgc tctc    atg tta caa att tgg gtt     652
                                          Met Leu Gln Ile Trp Val
                                            1               5

 aca ctt aac aat gaa aac ttg gta ttt aag gaa aat gtt ggg aga agc      700
 Thr Leu Asn Asn Glu Asn Leu Val Phe Lys Glu Asn Val Gly Arg Ser
              10                  15                  20

 cca cag ata aca cac ttg ctc tgt tta atg cta ata aat tgc att ttt      748
 Pro Gln Ile Thr His Leu Leu Cys Leu Met Leu Ile Asn Cys Ile Phe
          25                  30                  35

 tct tta ttg tta tta ttg tca cat gca gat ggg atg cat tta ttt ata      796
 Ser Leu Leu Leu Leu Leu Ser His Ala Asp Gly Met His Leu Phe Ile
      40                  45                  50

 agt tct ggg gat agg ata ctt ttt tgc ctg tac ttt tta cat tcc aga      844
 Ser Ser Gly Asp Arg Ile Leu Phe Cys Leu Tyr Phe Leu His Ser Arg
  55                  60                  65                  70

 gtt tgt gct tga ctt catcttgact aagacagatg agaatatttc ctagaatttg      899
 Val Cys Ala 


 t                                                                    900




      <210> 92
      <211> 2193
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(1229)

      <400> 92
 cggtggaatt ggcccaggat gacagctgga ga  atg gag tca gtt tta tcc aag      53
                                      Met Glu Ser Val Leu Ser Lys
                                        1               5

 tat gaa gat cag att act att ttc act gac tac cta gaa gaa tat cca      101
 Tyr Glu Asp Gln Ile Thr Ile Phe Thr Asp Tyr Leu Glu Glu Tyr Pro
          10                  15                  20

 gat aca gat gag ctg gta tgg atc tta ggg aag cag cat ctc ctt aaa      149
 Asp Thr Asp Glu Leu Val Trp Ile Leu Gly Lys Gln His Leu Leu Lys
      25                  30                  35

 aca gaa aaa tct aag ctg ttg tct gat ata agt gct cgt cta tgg ttt      197
 Thr Glu Lys Ser Lys Leu Leu Ser Asp Ile Ser Ala Arg Leu Trp Phe
  40                  45                  50                  55

 aca tac aga agg aaa ttt tca cca att ggt gga acg ggc cct tca tca      245
 Thr Tyr Arg Arg Lys Phe Ser Pro Ile Gly Gly Thr Gly Pro Ser Ser
                  60                  65                  70

 gat gct ggt tgg gga tgt atg cta cgc tgt gga cag atg atg ctg gct      293
 Asp Ala Gly Trp Gly Cys Met Leu Arg Cys Gly Gln Met Met Leu Ala
              75                  80                  85

 caa gcc ctt atc tgt aga cac ttg gga agg gac tgg agc tgg gag aaa      341
 Gln Ala Leu Ile Cys Arg His Leu Gly Arg Asp Trp Ser Trp Glu Lys
          90                  95                 100

 caa aaa gaa caa ccc aaa gaa tac caa cgc atc cta cag tgc ttc tta      389
 Gln Lys Glu Gln Pro Lys Glu Tyr Gln Arg Ile Leu Gln Cys Phe Leu
     105                 110                 115

 gat aga aaa gat tgt tgc tac tct atc cat caa atg gca caa atg ggt      437
 Asp Arg Lys Asp Cys Cys Tyr Ser Ile His Gln Met Ala Gln Met Gly
 120                 125                 130                 135

 gta gga gaa ggg aaa tca att gga gaa tgg ttt gga cca aat aca gtt      485
 Val Gly Glu Gly Lys Ser Ile Gly Glu Trp Phe Gly Pro Asn Thr Val
                 140                 145                 150

 gca cag gtg tta aaa aaa ctt gct tta ttt gac gaa tgg aat tcc ttg      533
 Ala Gln Val Leu Lys Lys Leu Ala Leu Phe Asp Glu Trp Asn Ser Leu
             155                 160                 165

 gct gtt tat gtt tca atg gat aac aca gtg gtc att gaa gat atc aaa      581
 Ala Val Tyr Val Ser Met Asp Asn Thr Val Val Ile Glu Asp Ile Lys
         170                 175                 180

 aaa atg tgc cgt gtc ctt ccc ttg agt gct gac aca gct ggt gac agg      629
 Lys Met Cys Arg Val Leu Pro Leu Ser Ala Asp Thr Ala Gly Asp Arg
     185                 190                 195

 cct ccc gat tct tta act gct tca aac cag agt aag ggc acc tct gcc      677
 Pro Pro Asp Ser Leu Thr Ala Ser Asn Gln Ser Lys Gly Thr Ser Ala
 200                 205                 210                 215

 tac tgc tca gcc tgg aaa ccc ctg ctg ctc att gtg ccc ctt cgc ctg      725
 Tyr Cys Ser Ala Trp Lys Pro Leu Leu Leu Ile Val Pro Leu Arg Leu
                 220                 225                 230

 ggc ata aac caa atc aat cct gtc tat gtt gat gca ttc aaa gag tgt      773
 Gly Ile Asn Gln Ile Asn Pro Val Tyr Val Asp Ala Phe Lys Glu Cys
             235                 240                 245

 ttt aag atg cca cag tct tta ggg gca tta gga gga aaa cca aat aac      821
 Phe Lys Met Pro Gln Ser Leu Gly Ala Leu Gly Gly Lys Pro Asn Asn
         250                 255                 260

 gcg tat tat ttc ata gga ttc tta ggt gac gag ctc atc ttc ttg gac      869
 Ala Tyr Tyr Phe Ile Gly Phe Leu Gly Asp Glu Leu Ile Phe Leu Asp
     265                 270                 275

 cct cat aca acc cag acc ttt gtt gac act gaa gag aat gga acg gtt      917
 Pro His Thr Thr Gln Thr Phe Val Asp Thr Glu Glu Asn Gly Thr Val
 280                 285                 290                 295

 aat gac cag act ttc cat tgc ctg cag tcc cca cag cga atg aac atc      965
 Asn Asp Gln Thr Phe His Cys Leu Gln Ser Pro Gln Arg Met Asn Ile
                 300                 305                 310

 cta aac ctg gat cct tca gtt gca ttg gga ttt ttc tgc aaa gaa gaa     1013
 Leu Asn Leu Asp Pro Ser Val Ala Leu Gly Phe Phe Cys Lys Glu Glu
             315                 320                 325

 aaa gac ttt gat aac tgg tgt agc ctt gtt cag aag gaa att cta aag     1061
 Lys Asp Phe Asp Asn Trp Cys Ser Leu Val Gln Lys Glu Ile Leu Lys
         330                 335                 340

 gag aat tta agg atg ttt gaa tta gtt cag aaa cat cca tca cac tgg     1109
 Glu Asn Leu Arg Met Phe Glu Leu Val Gln Lys His Pro Ser His Trp
     345                 350                 355

 cct ccc ttt gta cct cca gcc aag cca gaa gtg aca acc act ggg gca     1157
 Pro Pro Phe Val Pro Pro Ala Lys Pro Glu Val Thr Thr Thr Gly Ala
 360                 365                 370                 375

 gaa ttc att gac tct act gag caa ctg gag gag ttt gat ctg gag gaa     1205
 Glu Phe Ile Asp Ser Thr Glu Gln Leu Glu Glu Phe Asp Leu Glu Glu
                 380                 385                 390

 gat ttt gag att ctg agt gtg tag aatcctggga actcaacttg aaggtctgtc    1259
 Asp Phe Glu Ile Leu Ser Val 
             395

 ttccatctgg caccataaaa acatgaactt attgcataaa acttttctag tcagcaagtg   1319

 cctgatatgc caatagcata caaactcaat agcaatcatg actgagccaa tcactgtttc   1379

 tcagaaaaac aaaacaaaac aaaacaaatg acagtaaccc ttccccggaa agaaatagaa   1439

 caatcatgga gcctaggagc agagagatga ggaggagttc attgcttccc agcttgtgtt   1499

 atatggctac agcaagtctt cagctgctgc aatgaggaaa tgggcatctg gaagacaaac   1559

 agcaactctc agcttgcttc aagaaccagc agataagaga tggttaagct gttcttcacc   1619

 ctttcagatg tgacctcttt tggactaagc agcaatctgt tctcttgctc aaataataaa   1679

 gtgactgaat cagggaggaa aaggttcttg ttaaattatt tgattgtgta gttgaagtaa   1739

 ttataattta tatcaaaacg tttgtcaaag aaacgatgtc aaatatacac ttcttgatct   1799

 cccttctgtt tgcggggatc ttactatttg atgggtcact gtccccattc ttactgatac   1859

 ttttgtcaga tatcaccctg tccttaaatc atgatcactt aaatcagggg tcagcaaact   1919

 ttttctgtaa agggccagac gggaaatatt ttgggctttg caggccatgc ggcctctgtc   1979

 acatctactc aactctgctg ttgacatgca aaagcagcaa tagacaatat gcgtgtaaat   2039

 gagtgtggct gtaatccaag aaaactttat ttacaaaagc aggtggaggg ctgggtttgg   2099

 cctgcaggct gtagcttgcc aatcagtgac ttaaattgtt gatttttgtt tgataaatta   2159

 aaaataaatt gtgtttgaag tataaaaaaa aaaa                               2193




      <210> 93
      <211> 1406
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (110)..(826)

      <400> 93
 caaggaggat gaggtagcac catgccaggg gagatgccga gatgaagcca caccaccggc     60

 ctcaaggggc tcacagtctg atgaagagac acgtgcctat aagacacag    atg ggg     115
                                                          Met Gly
                                                            1

 ttc tgt gct aca gga atg caa aga aag gga cga ggc ctg ggg aag act      163
 Phe Cys Ala Thr Gly Met Gln Arg Lys Gly Arg Gly Leu Gly Lys Thr
           5                  10                  15

 tca cca aag aag cag cat ttg aat ctt ccc tta agg gaa aag gaa gta      211
 Ser Pro Lys Lys Gln His Leu Asn Leu Pro Leu Arg Glu Lys Glu Val
      20                  25                  30

 gga ctg tcc tgc cat gtg ggc aac ggc tca acc gtg gag gga ggt cac      259
 Gly Leu Ser Cys His Val Gly Asn Gly Ser Thr Val Glu Gly Gly His
  35                  40                  45                  50

 ttt ggg gcc ttt gca cac atc cga gtc aac ctc aac agt ctt agt cca      307
 Phe Gly Ala Phe Ala His Ile Arg Val Asn Leu Asn Ser Leu Ser Pro
                  55                  60                  65

 cac atc tct gta ttt ccg gtc act tat tgc tat gct gac tgc tca tct      355
 His Ile Ser Val Phe Pro Val Thr Tyr Cys Tyr Ala Asp Cys Ser Ser
              70                  75                  80

 aag ccc cag ata ctg tcc cag tta ttt agg aga caa aga ggc cct caa      403
 Lys Pro Gln Ile Leu Ser Gln Leu Phe Arg Arg Gln Arg Gly Pro Gln
          85                  90                  95

 gct ggc ctg agc ccc caa ggg gtc ctc agt gat gtc gac acg aca ggt      451
 Ala Gly Leu Ser Pro Gln Gly Val Leu Ser Asp Val Asp Thr Thr Gly
     100                 105                 110

 gtg cag gca ccc cca tgc aga cgg gcc cct ctg atg gag acc tgc gtt      499
 Val Gln Ala Pro Pro Cys Arg Arg Ala Pro Leu Met Glu Thr Cys Val
 115                 120                 125                 130

 cgg cca ggc agg ccc aca gct ggc gtg gtc atc cag ggc ggg aac ggg      547
 Arg Pro Gly Arg Pro Thr Ala Gly Val Val Ile Gln Gly Gly Asn Gly
                 135                 140                 145

 att gga cga agc ctt ccc tcg ggc aaa gat gct ggg gtg ggg aac agg      595
 Ile Gly Arg Ser Leu Pro Ser Gly Lys Asp Ala Gly Val Gly Asn Arg
             150                 155                 160

 tgc agc agg aac aga agg tca gag cgt ggt act ggg gtg acg aga ggc      643
 Cys Ser Arg Asn Arg Arg Ser Glu Arg Gly Thr Gly Val Thr Arg Gly
         165                 170                 175

 gct agc gaa cat cag cag ctg cgg gga gct cga ggc agc agg gat gtc      691
 Ala Ser Glu His Gln Gln Leu Arg Gly Ala Arg Gly Ser Arg Asp Val
     180                 185                 190

 cag gcc aca gaa gga att ggg tcc ctt cca tct gtg gcc atg acc gtt      739
 Gln Ala Thr Glu Gly Ile Gly Ser Leu Pro Ser Val Ala Met Thr Val
 195                 200                 205                 210

 cat ccc aca gcc tgt cct cct ctc ttg aga gct gtc ctg gct cag gct      787
 His Pro Thr Ala Cys Pro Pro Leu Leu Arg Ala Val Leu Ala Gln Ala
                 215                 220                 225

 gtg gct gga ttc tca agc agc atc atg tgg cca ggt tag gagcaggatg       836
 Val Ala Gly Phe Ser Ser Ser Ile Met Trp Pro Gly 
             230                 235

 tcacagagag aggggtccaa agttcagctg ctgggaaagg ccacaaagac tggggtccca    896

 ggagaacggc gacctgccta tcagttctat ctctaaaact ctggggttcg actctccaga    956

 cttagcttct gttcccagct ttacagagga caaggggctg ggcccatgag tctctctgca   1016

 tcagcaacac ctcactctca gttgaattca gactcgaaag cccagtctca acacagcaag   1076

 ccccatggga tccaagaaat actgctccat gcgtctgtta cccagttgtc tttttgctga   1136

 atcacattgt gggggcaaga agaaacatga ggccatctca acagatcgca aaggcctcca   1196

 cggctgggac atctgtaaag cgggaaacac gtgccggttc tcacgctacg acctagggag   1256

 atgaagacac ggtccctacc ccgagggatt tacaatcagg catggaaaat actccaaatc   1316

 caacaccaca ctgccacatg ctgatggtca tgccagagtg cacacaagga ctgtagaaac   1376

 atggaggaaa cctatcagat cattctatac                                    1406




      <210> 94
      <211> 1064
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (80)..(937)

      <400> 94
 tgtcttcgct gtcttcgcct tcacctcggt tgtggacctc atcatcgctc ttcaggaaga     60

 cagctatgtg gtgggcttc atg gag ttc tac acc aag gag gga gag cca tac     112
                      Met Glu Phe Tyr Thr Lys Glu Gly Glu Pro Tyr
                        1               5                  10

 ctg cgc aca gcg cac gga gtc ttc atc tgc tac tgg gat ggc act gtt      160
 Leu Arg Thr Ala His Gly Val Phe Ile Cys Tyr Trp Asp Gly Thr Val
              15                  20                  25

 cac tac ctc ctc tac ctg gcc atg gcc ggc gcc atc tgc aga agg aag      208
 His Tyr Leu Leu Tyr Leu Ala Met Ala Gly Ala Ile Cys Arg Arg Lys
          30                  35                  40

 aga tac cgg aat ttt gga ctc tac tgg ctg ggt tcc ttc gcc atg agc      256
 Arg Tyr Arg Asn Phe Gly Leu Tyr Trp Leu Gly Ser Phe Ala Met Ser
      45                  50                  55

 atc ctg gtg ttc ctt aca gga aac att ctt ggc aaa tac agc tcc gag      304
 Ile Leu Val Phe Leu Thr Gly Asn Ile Leu Gly Lys Tyr Ser Ser Glu
  60                  65                  70                  75

 atc agg cct gcc ttc ttc ctc acc atc ccc tac ctg ctg gtg cca tgc      352
 Ile Arg Pro Ala Phe Phe Leu Thr Ile Pro Tyr Leu Leu Val Pro Cys
                  80                  85                  90

 tgg gct ggc atg aag gtc ttc agc cag ccc cgg gcg cta acc cgc tgc      400
 Trp Ala Gly Met Lys Val Phe Ser Gln Pro Arg Ala Leu Thr Arg Cys
              95                 100                 105

 acc gcc aac atg gtg caa gag gaa caa aga aag gga ctc ctg cag cgt      448
 Thr Ala Asn Met Val Gln Glu Glu Gln Arg Lys Gly Leu Leu Gln Arg
         110                 115                 120

 ccg gct gac ctg gcc ctt gtc ata tat ctc atc ctt gct ggc ttc ttc      496
 Pro Ala Asp Leu Ala Leu Val Ile Tyr Leu Ile Leu Ala Gly Phe Phe
     125                 130                 135

 act ctg ttc cgg ggc ctg gtg gtg ctt gat tgc ccc aca gat gcc tgc      544
 Thr Leu Phe Arg Gly Leu Val Val Leu Asp Cys Pro Thr Asp Ala Cys
 140                 145                 150                 155

 ttt gtc tat atc tac cag tat gag cca tac ctg cgg gac cct gtg gcc      592
 Phe Val Tyr Ile Tyr Gln Tyr Glu Pro Tyr Leu Arg Asp Pro Val Ala
                 160                 165                 170

 tac cct aag gtg cag atg ctg atg tac atg ttt tat gtc ctg cct ttc      640
 Tyr Pro Lys Val Gln Met Leu Met Tyr Met Phe Tyr Val Leu Pro Phe
             175                 180                 185

 tgc ggc ctg gct gcc tat gct ctc acc ttc cct ggt tgc tcc tgg ctt      688
 Cys Gly Leu Ala Ala Tyr Ala Leu Thr Phe Pro Gly Cys Ser Trp Leu
         190                 195                 200

 cca gac tgg gcc ttg gtg ttt gct gga ggc atc ggc cag gca cag ttc      736
 Pro Asp Trp Ala Leu Val Phe Ala Gly Gly Ile Gly Gln Ala Gln Phe
     205                 210                 215

 tcg cac atg ggg gct tcc atg cac ctg cgc aca ccc ttc acc tac cgt      784
 Ser His Met Gly Ala Ser Met His Leu Arg Thr Pro Phe Thr Tyr Arg
 220                 225                 230                 235

 gtg cct gag gac acc tgg ggc tgc ttc ttc gtg tgc aat ctg ctg tat      832
 Val Pro Glu Asp Thr Trp Gly Cys Phe Phe Val Cys Asn Leu Leu Tyr
                 240                 245                 250

 gcg ctg ggc ccc cac ctg ctg gcc tac cgt tgc ctt cag tgg ccc gca      880
 Ala Leu Gly Pro His Leu Leu Ala Tyr Arg Cys Leu Gln Trp Pro Ala
             255                 260                 265

 ttc ttc cac cag cca cca ccc tcc gac ccc cta gcc ctc cac aag aag      928
 Phe Phe His Gln Pro Pro Pro Ser Asp Pro Leu Ala Leu His Lys Lys
         270                 275                 280

 cag cat tga gagagct gtgtactcag gacccaggac tctgtttacg tgcccagtca      984
 Gln His 
     285

 gccctacctg gggaagcggg ggctgggtgt tttagagaca ggagggacat ctacgggtgt   1044

 ctttagtgtg gcatatggta                                               1064




      <210> 95
      <211> 3924
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (311)..(3877)

      <400> 95
 agtgcccaca tggcaatggt ggatgccctg atgatggcct acactgtgga gatgatcagc     60

 atcgagaagg tggtggccag tgtcaagcgc ttctcaacgt tcagtgcctc gaaagaactt    120

 ccgtacgacc tcgaggatgc catggtgttc tggatcaaca aggtatatct tagaatgaga    180

 gagataacag agaaagaagt gtaaattaaa acaacagtta ttggaaagtc cagctcatca    240

 aaaggtccgc tatcgacgag agcacctttc tgctaggcag tcaccctact tcccgttgtt    300

 ggaggatttg   atg aga gac ggc agt gat ggt gct gct ctc tta gct gtg     349
              Met Arg Asp Gly Ser Asp Gly Ala Ala Leu Leu Ala Val
                1               5                  10

 att cac tat tat tgc cca gag cag atg aaa ctg gat gat ata tgc tta      397
 Ile His Tyr Tyr Cys Pro Glu Gln Met Lys Leu Asp Asp Ile Cys Leu
      15                  20                  25

 aag gag gta acg tcg atg gcc gac agt ctg tat aat att cgg ctt ctg      445
 Lys Glu Val Thr Ser Met Ala Asp Ser Leu Tyr Asn Ile Arg Leu Leu
  30                  35                  40                  45

 aga gaa ttc tcc aat gaa tat ctt aat aaa tgt ttt tat ctc acc ttg      493
 Arg Glu Phe Ser Asn Glu Tyr Leu Asn Lys Cys Phe Tyr Leu Thr Leu
                  50                  55                  60

 gaa gat atg ctg tat gcg cca tta gtg ttg aag ccg aat gtt atg gtt      541
 Glu Asp Met Leu Tyr Ala Pro Leu Val Leu Lys Pro Asn Val Met Val
              65                  70                  75

 ttt att gcg gag ctt ttt tgg tgg ttc gag aat gtc aag cca gat ttt      589
 Phe Ile Ala Glu Leu Phe Trp Trp Phe Glu Asn Val Lys Pro Asp Phe
          80                  85                  90

 gtt cag ccc agg gat gtt cag gag ctg aaa gac gcg aaa aca gtg tta      637
 Val Gln Pro Arg Asp Val Gln Glu Leu Lys Asp Ala Lys Thr Val Leu
      95                 100                 105

 cac cag aag agc agc cgg cct cct gta ccg atc tcc aac gcg acc aaa      685
 His Gln Lys Ser Ser Arg Pro Pro Val Pro Ile Ser Asn Ala Thr Lys
 110                 115                 120                 125

 cgc agt ttc cta ggc agc cct gct gca ggg acc ctg gct gag ctg cag      733
 Arg Ser Phe Leu Gly Ser Pro Ala Ala Gly Thr Leu Ala Glu Leu Gln
                 130                 135                 140

 ccc ccc gtg cag ctg ccg gcg gaa ggc tgt cac agg cac tac ctg cac      781
 Pro Pro Val Gln Leu Pro Ala Glu Gly Cys His Arg His Tyr Leu His
             145                 150                 155

 ccg gaa gaa cct gaa tac ctc ggg aaa gga act gct gcc ttc agc cca      829
 Pro Glu Glu Pro Glu Tyr Leu Gly Lys Gly Thr Ala Ala Phe Ser Pro
         160                 165                 170

 tcc cat cct tta ttg cca ctg aga cag aaa cag cag aaa tcc ata cag      877
 Ser His Pro Leu Leu Pro Leu Arg Gln Lys Gln Gln Lys Ser Ile Gln
     175                 180                 185

 gga gag gac atc cct gat cag cga cat cga tcg aat tct ttg acc cga      925
 Gly Glu Asp Ile Pro Asp Gln Arg His Arg Ser Asn Ser Leu Thr Arg
 190                 195                 200                 205

 gtt gat ggt cag cct cga gga gca gca ata gcc tgg cca gaa aaa aaa      973
 Val Asp Gly Gln Pro Arg Gly Ala Ala Ile Ala Trp Pro Glu Lys Lys
                 210                 215                 220

 acc agg cct gcg tcc cag cca aca cct ttt gct cta cat cac gct gcg     1021
 Thr Arg Pro Ala Ser Gln Pro Thr Pro Phe Ala Leu His His Ala Ala
             225                 230                 235

 agt tgt gaa gtg gat ccc agc tct ggc gac agc atc agc ttg gcc cgc     1069
 Ser Cys Glu Val Asp Pro Ser Ser Gly Asp Ser Ile Ser Leu Ala Arg
         240                 245                 250

 tcc atc agc aaa gac agt ttg gca tcc aac att gtt aat ctg acc cca     1117
 Ser Ile Ser Lys Asp Ser Leu Ala Ser Asn Ile Val Asn Leu Thr Pro
     255                 260                 265

 cag aac cag cca cac ccc acg gcc acg aag agc cac ggg aag agc ctc     1165
 Gln Asn Gln Pro His Pro Thr Ala Thr Lys Ser His Gly Lys Ser Leu
 270                 275                 280                 285

 ctg agc aat gtc agt att gag gat gag gaa gag gag ctt gtg gct att     1213
 Leu Ser Asn Val Ser Ile Glu Asp Glu Glu Glu Glu Leu Val Ala Ile
                 290                 295                 300

 gtt aga gca gac gtg gtt ccc cag cag gct gac ccg gag ttc ccc agg     1261
 Val Arg Ala Asp Val Val Pro Gln Gln Ala Asp Pro Glu Phe Pro Arg
             305                 310                 315

 gcc tca ccc cgg gcc tta ggc ctt aca gca aat gcc cgg tct ccc caa     1309
 Ala Ser Pro Arg Ala Leu Gly Leu Thr Ala Asn Ala Arg Ser Pro Gln
         320                 325                 330

 gga cag ctg gac acc tcg gaa agt aag cct gac agt ttt ttc ttg gag     1357
 Gly Gln Leu Asp Thr Ser Glu Ser Lys Pro Asp Ser Phe Phe Leu Glu
     335                 340                 345

 cct ttg atg cca gca gtt ctt aag cca gcg aaa gag aag cag gtg atc     1405
 Pro Leu Met Pro Ala Val Leu Lys Pro Ala Lys Glu Lys Gln Val Ile
 350                 355                 360                 365

 acc aag gag gat gaa cgg ggg gaa ggg aga ccg agg agc atc gtg tct     1453
 Thr Lys Glu Asp Glu Arg Gly Glu Gly Arg Pro Arg Ser Ile Val Ser
                 370                 375                 380

 agg agg ccc agc gag ggc ccc cag cct ttg gta cga agg aaa atg act     1501
 Arg Arg Pro Ser Glu Gly Pro Gln Pro Leu Val Arg Arg Lys Met Thr
             385                 390                 395

 ggc agt cgc gac ttg aat agg act ttt acc ccg att cca tgc tca gaa     1549
 Gly Ser Arg Asp Leu Asn Arg Thr Phe Thr Pro Ile Pro Cys Ser Glu
         400                 405                 410

 ttc ccc atg ggc atc gac ccc acc gag aca gga cca ctg tca gtg gaa     1597
 Phe Pro Met Gly Ile Asp Pro Thr Glu Thr Gly Pro Leu Ser Val Glu
     415                 420                 425

 acc gca gga gag gtc tgt ggt ggg cct ctg gcc ctt ggc gga ttc gat     1645
 Thr Ala Gly Glu Val Cys Gly Gly Pro Leu Ala Leu Gly Gly Phe Asp
 430                 435                 440                 445

 ccg ttc ccc cag gga cca tcc acg gat ggc ttc ttc ctt cat gta ggc     1693
 Pro Phe Pro Gln Gly Pro Ser Thr Asp Gly Phe Phe Leu His Val Gly
                 450                 455                 460

 agg gcc gat gaa gac acc gag gga agg tta tat gtt agt tgt tca aaa     1741
 Arg Ala Asp Glu Asp Thr Glu Gly Arg Leu Tyr Val Ser Cys Ser Lys
             465                 470                 475

 agc ccc aac tcc cac gat tca gag ccg tgg act ctc ctc agg cag gat     1789
 Ser Pro Asn Ser His Asp Ser Glu Pro Trp Thr Leu Leu Arg Gln Asp
         480                 485                 490

 tct gac tcg gat gtg gtg gac ata gag gaa gcc gag cac gat ttc atg     1837
 Ser Asp Ser Asp Val Val Asp Ile Glu Glu Ala Glu His Asp Phe Met
     495                 500                 505

 ggt gag gcc cat cct gtg gtt ttc agc aga tac att ggg gag gaa gag     1885
 Gly Glu Ala His Pro Val Val Phe Ser Arg Tyr Ile Gly Glu Glu Glu
 510                 515                 520                 525

 tcg gcc aaa ctg cag gag gac atg aag gtg aag gaa cat gaa gac aaa     1933
 Ser Ala Lys Leu Gln Glu Asp Met Lys Val Lys Glu His Glu Asp Lys
                 530                 535                 540

 gat gac gcc agc ggc cgc tcg agc ccc tgc ctg agc aca gcc tct cag     1981
 Asp Asp Ala Ser Gly Arg Ser Ser Pro Cys Leu Ser Thr Ala Ser Gln
             545                 550                 555

 atg agc agt gtc tcc atg gcg agt ggg agc gtg aag atg acc agc ttt     2029
 Met Ser Ser Val Ser Met Ala Ser Gly Ser Val Lys Met Thr Ser Phe
         560                 565                 570

 gcg gag agg aag ctc cag aga ctc aac agc tgt gag acc aag tcc agc     2077
 Ala Glu Arg Lys Leu Gln Arg Leu Asn Ser Cys Glu Thr Lys Ser Ser
     575                 580                 585

 acc agc agc tcc cag aag acc acg cca gat gcg tct gag agc tgc cca     2125
 Thr Ser Ser Ser Gln Lys Thr Thr Pro Asp Ala Ser Glu Ser Cys Pro
 590                 595                 600                 605

 gcc cct ctg acg acg tgg agg cag aag agg gag cag agt ccg agc cag     2173
 Ala Pro Leu Thr Thr Trp Arg Gln Lys Arg Glu Gln Ser Pro Ser Gln
                 610                 615                 620

 cat ggc aag gat ccc gcc agc ctc ctg gca tct gag ctg gta cag ctg     2221
 His Gly Lys Asp Pro Ala Ser Leu Leu Ala Ser Glu Leu Val Gln Leu
             625                 630                 635

 cac atg cag ctg gag gag aag cgc agg gcc atc gag gcc cag aag aag     2269
 His Met Gln Leu Glu Glu Lys Arg Arg Ala Ile Glu Ala Gln Lys Lys
         640                 645                 650

 aag atg gag gcg ctg tcg gca agg cag cgc ctg aag ctc ggc aag gct     2317
 Lys Met Glu Ala Leu Ser Ala Arg Gln Arg Leu Lys Leu Gly Lys Ala
     655                 660                 665

 gca ttc ctg cat gtg gtg aag aag ggc aag gcc gag gct gcc cca ccc     2365
 Ala Phe Leu His Val Val Lys Lys Gly Lys Ala Glu Ala Ala Pro Pro
 670                 675                 680                 685

 ctc agg ccg gag cac ttt gca aag gag tac tct cag cac aac ggg gag     2413
 Leu Arg Pro Glu His Phe Ala Lys Glu Tyr Ser Gln His Asn Gly Glu
                 690                 695                 700

 gac tgt ggg gac gct gtt tcc aaa acc gaa gac ttt ctc gtg aag gag     2461
 Asp Cys Gly Asp Ala Val Ser Lys Thr Glu Asp Phe Leu Val Lys Glu
             705                 710                 715

 gag cag aga gag gag ctc ctt cac gag cca cag gat gtg gac aaa gag     2509
 Glu Gln Arg Glu Glu Leu Leu His Glu Pro Gln Asp Val Asp Lys Glu
         720                 725                 730

 agc ctg gcc ttt gct cag caa cat aaa gca aaa gac cct gtg gct ctg     2557
 Ser Leu Ala Phe Ala Gln Gln His Lys Ala Lys Asp Pro Val Ala Leu
     735                 740                 745

 cac gag ctg gag aga aat aag gtg atc tcc gct gcc ctc ctg gag gac     2605
 His Glu Leu Glu Arg Asn Lys Val Ile Ser Ala Ala Leu Leu Glu Asp
 750                 755                 760                 765

 act gtt ggg gag gtt gtc gac gtg aat gaa tgt gac ctt tcc atc gag     2653
 Thr Val Gly Glu Val Val Asp Val Asn Glu Cys Asp Leu Ser Ile Glu
                 770                 775                 780

 aag ctt aac gaa acc atc agt acg ctg cag cag gcc atc ctg aaa atc     2701
 Lys Leu Asn Glu Thr Ile Ser Thr Leu Gln Gln Ala Ile Leu Lys Ile
             785                 790                 795

 tct cag cag caa gag cag ctt ctg atg aag tcc ccc aca gtc cca gtg     2749
 Ser Gln Gln Gln Glu Gln Leu Leu Met Lys Ser Pro Thr Val Pro Val
         800                 805                 810

 cca ggc tct aag aat aac tcg cag gac cac aaa gtg aag gca cca gtc     2797
 Pro Gly Ser Lys Asn Asn Ser Gln Asp His Lys Val Lys Ala Pro Val
     815                 820                 825

 cac ttc gtg gag cca ctc tct ccc acg ggc gtg gct ggc cac cgc aaa     2845
 His Phe Val Glu Pro Leu Ser Pro Thr Gly Val Ala Gly His Arg Lys
 830                 835                 840                 845

 gcc ccc cgg ctg ggt caa ggc cgg aat tcc cgt tcc gga agg ccg gcg     2893
 Ala Pro Arg Leu Gly Gln Gly Arg Asn Ser Arg Ser Gly Arg Pro Ala
                 850                 855                 860

 gag ctg aag gtc cca aaa gac agg cca cag ggc tcc tcc cga agt aaa     2941
 Glu Leu Lys Val Pro Lys Asp Arg Pro Gln Gly Ser Ser Arg Ser Lys
             865                 870                 875

 acc cca acg ccc agt gta gag acg ctc ccg cac ttg aga ccc ttc cct     2989
 Thr Pro Thr Pro Ser Val Glu Thr Leu Pro His Leu Arg Pro Phe Pro
         880                 885                 890

 gcc agc agc cac cct cgg acg ccc acg gac cct ggc ctg gac agt gcc     3037
 Ala Ser Ser His Pro Arg Thr Pro Thr Asp Pro Gly Leu Asp Ser Ala
     895                 900                 905

 ctg gag ccc agt ggt gac cca cat ggg aag tgt ctc ttc gac agt tac     3085
 Leu Glu Pro Ser Gly Asp Pro His Gly Lys Cys Leu Phe Asp Ser Tyr
 910                 915                 920                 925

 agg ctc cat gat gaa agc aat cag cgg aca ctt act ctg tcc tct tcc     3133
 Arg Leu His Asp Glu Ser Asn Gln Arg Thr Leu Thr Leu Ser Ser Ser
                 930                 935                 940

 aaa gat gcc aac att ctt tcg gag cag atg agc ctc aaa gaa gtt ctg     3181
 Lys Asp Ala Asn Ile Leu Ser Glu Gln Met Ser Leu Lys Glu Val Leu
             945                 950                 955

 gat gcg agt gtg aag gag gtg ggg tcc agc tcc tca gat gtc tcg gga     3229
 Asp Ala Ser Val Lys Glu Val Gly Ser Ser Ser Ser Asp Val Ser Gly
         960                 965                 970

 aaa gag agc gtc ccc gtg gag gag cct ctg agg agc agg gcc agc ctc     3277
 Lys Glu Ser Val Pro Val Glu Glu Pro Leu Arg Ser Arg Ala Ser Leu
     975                 980                 985

 att gaa gtg gac ctc tcc gac ctg aag gcc ccc gac gag gat ggg gag     3325
 Ile Glu Val Asp Leu Ser Asp Leu Lys Ala Pro Asp Glu Asp Gly Glu
 990                 995                1000                1005

 ctg gta agc ctc gat ggc tcg gcg gac ctt gtc agc gaa ggc gac cag     3373
 Leu Val Ser Leu Asp Gly Ser Ala Asp Leu Val Ser Glu Gly Asp Gln
                1010                1015                1020

 aag ccg ggg gtc ggc ttc ttc ttc aag gat gaa cag aaa gcg gaa gat     3421
 Lys Pro Gly Val Gly Phe Phe Phe Lys Asp Glu Gln Lys Ala Glu Asp
            1025                1030                1035

 gag ctc gcc aag aag cgg gcg gcc ttc ctc ctg aag cag cag cgc aag     3469
 Glu Leu Ala Lys Lys Arg Ala Ala Phe Leu Leu Lys Gln Gln Arg Lys
        1040                1045                1050

 gcc gag gag gcc cgc gtg cgc aag cag cag ctt ctg atg aag tcc ccc     3517
 Ala Glu Glu Ala Arg Val Arg Lys Gln Gln Leu Leu Met Lys Ser Pro
    1055                1060                1065

 aca gtc cca gtg cca ggc tct aag aat aac tcg cag gac cac aaa gtg     3565
 Thr Val Pro Val Pro Gly Ser Lys Asn Asn Ser Gln Asp His Lys Val
1070                1075                1080                1085

 aag gca cca gtc cac ttc gtg gag cca ctc tct ccc acg ggc gtg gct     3613
 Lys Ala Pro Val His Phe Val Glu Pro Leu Ser Pro Thr Gly Val Ala
                1090                1095                1100

 ggc cac cgc aaa gcc ccc cgg ctg ggt caa ggc cgg aat tcc cgt tcc     3661
 Gly His Arg Lys Ala Pro Arg Leu Gly Gln Gly Arg Asn Ser Arg Ser
            1105                1110                1115

 gga agg ccg gcg gag ctg aag gtc cca aaa gac agg cca cag ggc tcc     3709
 Gly Arg Pro Ala Glu Leu Lys Val Pro Lys Asp Arg Pro Gln Gly Ser
        1120                1125                1130

 tcc cga agt aaa acc cca acg ccc agt gta gag acg ctc ccg cac ttg     3757
 Ser Arg Ser Lys Thr Pro Thr Pro Ser Val Glu Thr Leu Pro His Leu
    1135                1140                1145

 aga ccc ttc cct gcc aac agc cac ccc tgg acg ccc acg gac cct ggc     3805
 Arg Pro Phe Pro Ala Asn Ser His Pro Trp Thr Pro Thr Asp Pro Gly
1150                1155                1160                1165

 ctg gac agt gcc ctg gaa ccc aat ggg gac cca cat tgg aaa gtg ttt     3853
 Leu Asp Ser Ala Leu Glu Pro Asn Gly Asp Pro His Trp Lys Val Phe
                1170                1175                1180

 ttt cga cag tta ccg gct tca tga tgaaagccat ttggggcact ttacttttgg    3907
 Phe Arg Gln Leu Pro Ala Ser 
            1185

 ccttttccaa agatccc                                                  3924




      <210> 96
      <211> 1085
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (47)..(679)

      <400> 96
 gcacgagcgg caggttcccg cccggaagaa gcgaccaaag cgcctg   atg acc ggc      55
                                                      Met Thr Gly
                                                        1

 aac atg gtg cgg tcg ggg aat aag gca gct gtt gtg ctg tgt atg gac      103
 Asn Met Val Arg Ser Gly Asn Lys Ala Ala Val Val Leu Cys Met Asp
       5                  10                  15

 gtg ggc ttt acc atg agt aac tcc att cct ggt ata gaa tcc cca ttt      151
 Val Gly Phe Thr Met Ser Asn Ser Ile Pro Gly Ile Glu Ser Pro Phe
  20                  25                  30                  35

 gaa caa gca aag aag gtg ata acc atg ttt gta cag cga cag gtg ttt      199
 Glu Gln Ala Lys Lys Val Ile Thr Met Phe Val Gln Arg Gln Val Phe
                  40                  45                  50

 gct gag aac aag gat gag att gct tta gtc ctg ttt ggt aca gat ggc      247
 Ala Glu Asn Lys Asp Glu Ile Ala Leu Val Leu Phe Gly Thr Asp Gly
              55                  60                  65

 act gac aat ccc ctt tct ggt ggg gat cag tat cag aac atc aca gtg      295
 Thr Asp Asn Pro Leu Ser Gly Gly Asp Gln Tyr Gln Asn Ile Thr Val
          70                  75                  80

 cac aga cat ctg atg cta cca gat ttt gat ttg ctg gag gac att gaa      343
 His Arg His Leu Met Leu Pro Asp Phe Asp Leu Leu Glu Asp Ile Glu
      85                  90                  95

 agc aaa atc caa cca ggt tct caa cag gct gac ttc ctg gat gca cta      391
 Ser Lys Ile Gln Pro Gly Ser Gln Gln Ala Asp Phe Leu Asp Ala Leu
 100                 105                 110                 115

 atc gtg agc atg gat gtg att caa cat gaa aca att gga aag aag ttt      439
 Ile Val Ser Met Asp Val Ile Gln His Glu Thr Ile Gly Lys Lys Phe
                 120                 125                 130

 gag aag agg cat att gaa ata ttc act gac ctc agc agc cga ttc agc      487
 Glu Lys Arg His Ile Glu Ile Phe Thr Asp Leu Ser Ser Arg Phe Ser
             135                 140                 145

 aaa agt cag ctg gat att ata att cat agc ttg aag aaa tgt gac atc      535
 Lys Ser Gln Leu Asp Ile Ile Ile His Ser Leu Lys Lys Cys Asp Ile
         150                 155                 160

 tcc ctg caa ttc ttc ttg cct ttc tca ctt ggc aag gaa gat gga agt      583
 Ser Leu Gln Phe Phe Leu Pro Phe Ser Leu Gly Lys Glu Asp Gly Ser
     165                 170                 175

 ggg gac acg agg aga tgg ccc ctt tcg ctt agg tgg cca tgg gcc ctt      631
 Gly Asp Thr Arg Arg Trp Pro Leu Ser Leu Arg Trp Pro Trp Ala Leu
 180                 185                 190                 195

 cct ttt cca cta aaa gga att acg aga aca gca aaa aga agg tct tga      679
 Pro Phe Pro Leu Lys Gly Ile Thr Arg Thr Ala Lys Arg Arg Ser 
                 200                 205                 210

 gatagtgaaa atggtgatga tatcttttag aaaaggtcgc acgaatgggg tcggatgcac    739

 attctatccc atttcacttg agacgtcttg agaaacctgg tgccgtcatt ccacgaaaaa    799

 ttcgagaggc ttcccatcca ctgggcctgg cgacgtgaca atggtcccac ttagttataa    859

 aagattgaag ctatagtggt tctacgggaa caagttacca acttagacag gcgtgatcaa    919

 aacctcaaca gaacatcaaa cagaccaatt gtcaacagac tagcaaacgc attcgcatga    979

 gctatcacgc tcaacagcga tgccgccaac gggagaaaac aacacacggg gatctggaca   1039

 aagcaggcca gacgcctgta acagaacgac gagccgcctc atcaac                  1085




      <210> 97
      <211> 920
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (541)..(897)

      <400> 97
 ggggcagcag ggatggtggg ctggagtagg gtgctggcaa tgagggagtc tggctcagat     60

 gtgggatgtg tatggaagaa tataaatgat ggtgtggatg tcagggtgag ggaggagaca    120

 aaaccacgat gacccctagc tttgtggcct gaactgtggg tggctgaggg gatcgttaat    180

 tgaatggggc agactgaggc ttgtgaggaa gatcagagtc tggttcttga catgagatgc    240

 ccttcagaca tctcttcact caggtccaac tagggataca gaaacactga atatttcaac    300

 agcagaaatt gaatgggggg attgatagcg ctggcgaggg aagcagctgg aaagagacag    360

 atggcaccct gagacagccc agaggtgaat aggaccccca ggctgcaggg ataaagctca    420

 gtggtggtgt tacctcaccg gggaccaggg tcacacagca aagctggaac aacagaggcg    480

 tgttgtgggg gagcctcaga ggggacaaaa cctctgcctg agatcccacc ccaggtgggc    540
                                                                 
 atg ggg gcc act gag gtt ggg gat gaa aat gcc ggt acc gtc agt gca      588
 Met Gly Ala Thr Glu Val Gly Asp Glu Asn Ala Gly Thr Val Ser Ala
   1               5                  10                  15

 cag ccc tgt tcc aga cag tgc tgc ctg gaa gat ttt tgg gct ttc ctg      636
 Gln Pro Cys Ser Arg Gln Cys Cys Leu Glu Asp Phe Trp Ala Phe Leu
              20                  25                  30

 agg ggc cac ccc gca cct gag cca cct cct tgg act cct gtc ctt tac      684
 Arg Gly His Pro Ala Pro Glu Pro Pro Pro Trp Thr Pro Val Leu Tyr
          35                  40                  45

 ccc ttg agg acc tcc ctc cct ttt acc cta gct gtt ttt ttg aac ttg      732
 Pro Leu Arg Thr Ser Leu Pro Phe Thr Leu Ala Val Phe Leu Asn Leu
      50                  55                  60

 gga ctt tcc ttt ccc aag act tcc atc act agc tcc tgg agg gac tgg      780
 Gly Leu Ser Phe Pro Lys Thr Ser Ile Thr Ser Ser Trp Arg Asp Trp
  65                  70                  75                  80

 act ttg cat ttt ccc ttt gcg tgg agc ctc agt gtg aaa ggc cct gcc      828
 Thr Leu His Phe Pro Phe Ala Trp Ser Leu Ser Val Lys Gly Pro Ala
                  85                  90                  95

 aat ggg tgc atg tca aag gtg gtg ggg acc aca tca aaa aaa aag ggg      876
 Asn Gly Cys Met Ser Lys Val Val Gly Thr Thr Ser Lys Lys Lys Gly
             100                 105                 110

 ggt gat gaa att aac aaa taa aaagtatggg gaaaaaaaaa aaa                920
 Gly Asp Glu Ile Asn Lys 
         115





      <210> 98
      <211> 930
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (124)..(396)

      <400> 98
 acctccccca acgccacccc gcttcgcagt agacggacag aggagtcgta gcggtcgagg     60

 cttttgcggc tccggcgtgc cggaaagtat gttatgcata aaagtggata atttacatga    120

 taa  atg aaa atg gcc aat tct tta aga gga gaa gta cta aaa ctt tat     168
      Met Lys Met Ala Asn Ser Leu Arg Gly Glu Val Leu Lys Leu Tyr
        1               5                  10                  15

 aaa aat ctg ctg tat ctt gga cga gac tat cca aaa gga gca gac tat      216
 Lys Asn Leu Leu Tyr Leu Gly Arg Asp Tyr Pro Lys Gly Ala Asp Tyr
                  20                  25                  30

 ttt aaa aag cgt ttg aag aac att ttc ctt aaa aac aaa gat gtg aag      264
 Phe Lys Lys Arg Leu Lys Asn Ile Phe Leu Lys Asn Lys Asp Val Lys
              35                  40                  45

 aat cca gag aag atc aaa gaa ctt att gca cag ggc gaa ttt gta atg      312
 Asn Pro Glu Lys Ile Lys Glu Leu Ile Ala Gln Gly Glu Phe Val Met
          50                  55                  60

 aaa gag cta gaa gct ttg tac ttc ctt agg aaa tac aga gct atg aaa      360
 Lys Glu Leu Glu Ala Leu Tyr Phe Leu Arg Lys Tyr Arg Ala Met Lys
      65                  70                  75

 caa cgc tat tat tca gat acc aac aaa act aat tga tcat tactacttta      410
 Gln Arg Tyr Tyr Ser Asp Thr Asn Lys Thr Asn 
  80                  85                  90

 atttagctat cagtgccagc tgtttatgta taccagatgt tgtaaaataa ttctaactta    470

 aaatgggaag atatacatgt tgtgtaaaaa atccctgagc tgccctactg aactaaatag    530

 gtttcaactt ctgttcatac ggagaaagta tcagcaactt tatgctcaat tttgatacaa    590

 acatagcaat ttagctatac taccgatcat aaattaatga gcacccaatt ttgaatgaaa    650

 atataataca cttaatcctc taacttaata ggacttagcc aattattttt agcttatttc    710

 tccattttac tgacgagaat gccatttacc gaacatttaa taagcaaaat aatttcttac    770

 acacttactt ctcttaactt ttgaaaggaa tcccttattt tttcacccaa tttggtatat    830

 taacagcaca tactcaaggt tcactacaaa acaaacagtt cctggtaatg atttaaatgt    890

 agttatagaa ataaataata tgtatggagt cattacttct                          930




      <210> 99
      <211> 2289
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1685)..(1939)

      <400> 99
 gcacgaggca gaacacaaca caccctcatt atccctaagc tgaagcatga ttttagtcac     60

 tttgattttg ttcgagtgtc atctggctgg tcaaaaataa gcaggacaga taaaatgtat    120

 ttcagacata ccatcagaaa atggtttatc accatcaaag gcaatccttt gaaagtgata    180

 gagtccctct aaaggtacag tccttagaaa gagggactgt attaaaaagt attttgggaa    240

 tatcaaagct ttaatattcc aacaaagact aagagaaaaa caatactcag tgggtgattg    300

 cagtcctaaa ttgtcatatg ttgttatttt caggtcaaga gcatcaactt caattccata    360

 cattcaccaa atattctcag tatacacaca gtcttgatta catgtatcaa tttcaccagt    420

 tatgacttct aaaaattata tatatttttt cagaacaaga ccactattat taactaactt    480

 gaacaattgt atcatccaaa ggccaaagat catatggcag atcagggaag tcatgaagtt    540

 gatttggtct tgacgtggaa aaccattaaa caacaaaagc aactgaaccc atgtatgcac    600

 agaaacaatc aaacactagt tcattttata gtgcccagga aaatgttcct tcttttaaaa    660

 tggattttat ttgaaagcgc agaaaatgaa aactagtgag atatattttt ggtattataa    720

 taggcaattg gttgaggttc aagtttagtt tcaggtaata ttatcaggga agattccatg    780

 ttttaaaata gtatttatgg atcatgggta ggttaagaaa gatgcattgg catatagtct    840

 tgatagttaa gtccacgatt atcattttag aatccaggct atgcttgctg ctctttttat    900

 ccacatttta aattacaatt gcatttttta cttgttcagt gcacactttg atgcaccaca    960

 agtgcattaa ttttgaatcg tgtgcaatat agaaatattt tgagactcac aacattgaaa   1020

 caaggtgaca ccctagttga ctttatcact aatgtgattt gaacattatt taaacaaatc   1080

 tagactgaac atgaaagaaa ggagttttgg gcagtgacat ttttcacaga atgtatatct   1140

 caaaggtgaa agcagagttt ttccagtgca ataaaaagaa acagaatatg cagattttga   1200

 gctactcgct ctatagagga taacctaaca cggctgaaaa ttgagctggg acattcagac   1260

 gaaagtgaca atccatggac agaataggga ataacaggtg tgaagagaac aaacttatca   1320

 ctgaatgttt gcaagctggt taaggcatag ccttgatggc tctctagcaa actgtagaaa   1380

 caatgtagct ttgggtagtt tcatgctttg cagaatttct tagactataa agtgacacag   1440

 cctggaatat aggttgataa ttcactatag gtcttcaaaa tacttatctt tgaaaaccac   1500

 ttctctgttt ggtggggtac aatttggggg tcatttcctt atgctctttc ttaaatggag   1560

 ttttcatttt gatgttagtt tatgtataat aggtaggatg caaaaagata tgtaattgaa   1620

 acaaaaaaca ttggactaaa atatcagtaa ttgaacatgt ttatgtttga ttattattta   1680

 cact atg gaa aga tgc aat tct agt act ttg tta gga aac tgc att aaa    1729
      Met Glu Arg Cys Asn Ser Ser Thr Leu Leu Gly Asn Cys Ile Lys
        1               5                  10                  15

 gca gtt ctg cct tgt ata atc tgt aag tac cta tta aga caa aat act     1777
 Ala Val Leu Pro Cys Ile Ile Cys Lys Tyr Leu Leu Arg Gln Asn Thr
                  20                  25                  30

 tct aaa gat act tat gaa atg tat aca tat ttt ttc ttg cac gtt aca     1825
 Ser Lys Asp Thr Tyr Glu Met Tyr Thr Tyr Phe Phe Leu His Val Thr
              35                  40                  45

 aag aaa ata ctc aat tgc ata aca cgg atg ttt gac aaa ctt ttt ttt     1873
 Lys Lys Ile Leu Asn Cys Ile Thr Arg Met Phe Asp Lys Leu Phe Phe
          50                  55                  60

 ttt aaa tgc att tct ttc ttt cat gag aca ttg aaa cca ctg ata gct     1921
 Phe Lys Cys Ile Ser Phe Phe His Glu Thr Leu Lys Pro Leu Ile Ala
      65                  70                  75

 cat ttc acc cta tct taa accctt ctcttgtcta taaaactaat acgggtcaca     1975
 His Phe Thr Leu Ser 
  80

 ccggaccttc ggattaattg gatccacatt ccccaatgat gtttgcaccc cattcaagat   2035

 agccatgcca ttgtcattta actcgtgaac ctctctttaa aactaaaatg gatgtgaaag   2095

 aataaaattc agtgtactgt aagtattcac agtaattcta gtagaattag ctgtcataac   2155

 atgtttatta tataatgagc tggcatgaca cagaaatata ttttgtgttt gtatgacttt   2215

 tattttaaat aggttaaatc tggtgccact ccatatatag agtgcttttg aaaaaaaatc   2275

 aacaaaaaaa aaaa                                                     2289




      <210> 100
      <211> 1243
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (532)..(1050)

      <400> 100
 ggtttcctcc tgttttcagt agagatggag atgaatccat cccttttttc ctatagtaat     60

 tccatccatt ctgtcaggag gaataggtat tggaagcctg ttgagcatcc aggggatcaa    120

 ggggtgttag acaagtggat tcttatcttt ctcccttctg ttctttctcc ttaggaccag    180

 ctttatccag ggactctacc attcccaccc ctttggcccc actccacgac aaccacttcc    240

 ccatcttctc ctctattctg gtctcccctg cccccacgcc ttcccaccca gcgtcttccc    300

 caggttcccc cactacctct ccctcagatc caggccctca gctcagcatg ggtggttctc    360

 cctccaggaa agggggagga gggaccagga cctgagttgc atagcggctg cctggatggg    420

 cttagaagcc tttttgaggg acctccctgc ccctatcctg gggcttggat acctttccaa    480

 gtccctggaa ctgcccaccc ttcccctgcc accccgtcag gagatcctag t atg gag     537
                                                          Met Glu
                                                            1

 gaa cat ctg tct gtc atg tat gag aga ctg aga caa gag ctt ccc aag      585
 Glu His Leu Ser Val Met Tyr Glu Arg Leu Arg Gln Glu Leu Pro Lys
           5                  10                  15

 ctc ttc ctt cag tcc cac gac tac agt ctg tat tcc ttg gat gtg gaa      633
 Leu Phe Leu Gln Ser His Asp Tyr Ser Leu Tyr Ser Leu Asp Val Glu
      20                  25                  30

 ttc atc aat gag atc ctc aac ata cgt acc aag ggc cgg aca tgg tac      681
 Phe Ile Asn Glu Ile Leu Asn Ile Arg Thr Lys Gly Arg Thr Trp Tyr
  35                  40                  45                  50

 att ctt tca ctg acc ctc tgc cgt ttc ctg gcc tgg aat tat ttt gca      729
 Ile Leu Ser Leu Thr Leu Cys Arg Phe Leu Ala Trp Asn Tyr Phe Ala
                  55                  60                  65

 cac ctt cgt ttg gag gtt tta cag ctg acc cgc cac cct gag aac tgg      777
 His Leu Arg Leu Glu Val Leu Gln Leu Thr Arg His Pro Glu Asn Trp
              70                  75                  80

 acc ctg caa gcc cgg tgg cgg ctt gtg ggg ctg ccc gtc cac ttg ctc      825
 Thr Leu Gln Ala Arg Trp Arg Leu Val Gly Leu Pro Val His Leu Leu
          85                  90                  95

 ttt ttg cgg ttc tac aag cgt gac aaa gac gag cat tac cgg acc tat      873
 Phe Leu Arg Phe Tyr Lys Arg Asp Lys Asp Glu His Tyr Arg Thr Tyr
     100                 105                 110

 gat gcc tac tcc act ttc tac ctg aat tcc agt ggc ctc att tgt cgc      921
 Asp Ala Tyr Ser Thr Phe Tyr Leu Asn Ser Ser Gly Leu Ile Cys Arg
 115                 120                 125                 130

 cat cgt cta gat aaa ctg atg cct tca cac tca cct cca acg cct gtg      969
 His Arg Leu Asp Lys Leu Met Pro Ser His Ser Pro Pro Thr Pro Val
                 135                 140                 145

 aag aag ctg cta gtg gga gcc ctg gtg gcc ctg ggg ctg tca gag cca     1017
 Lys Lys Leu Leu Val Gly Ala Leu Val Ala Leu Gly Leu Ser Glu Pro
             150                 155                 160

 gaa cct gac tta aac ctg tgt tcc aag ccc tga tccttgac cttggagtgg     1068
 Glu Pro Asp Leu Asn Leu Cys Ser Lys Pro 
         165                 170

 aggcagcact gaagactgct acgcccaaga gaaggaggtg gaggcagcca agaatctcag   1128

 gagccagctt cctctcctcg tttctctcct tccttccttt ccatctcatg ctgtgtaaag   1188

 ctgctgtgta atttaacttg taaataataa agtttaactg actataaaaa aaaaa        1243




      <210> 101
      <211> 868
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (143)..(607)

      <400> 101
 aaggatcctt aattaaatta atcccccccc cccgagaggc ttgtttgagg cccgcgggga     60

 ctgggcgggc ggaggccggg ctgccgaagt gtgaggggag gagcccgagc cgtcgctgct    120

 gccgccgcta agggagagga gc atg tct gca act cga gcc aag aaa gtg aag     172
                          Met Ser Ala Thr Arg Ala Lys Lys Val Lys
                            1               5                  10

 atg gcc acc aaa tca tgc ccc gag tgc gac caa cag gtt cct gtt gca      220
 Met Ala Thr Lys Ser Cys Pro Glu Cys Asp Gln Gln Val Pro Val Ala
                  15                  20                  25

 tgt aaa tca tgt cct tgt ggt tac ata ttt att agc aga aaa ctt tta      268
 Cys Lys Ser Cys Pro Cys Gly Tyr Ile Phe Ile Ser Arg Lys Leu Leu
              30                  35                  40

 aat gca aaa cac tca gag aaa tca cca cct tct aca gaa aac aag cat      316
 Asn Ala Lys His Ser Glu Lys Ser Pro Pro Ser Thr Glu Asn Lys His
          45                  50                  55

 gag gcc aag agg agg cga aca gag aga gtt agg aga gag aag ata aat      364
 Glu Ala Lys Arg Arg Arg Thr Glu Arg Val Arg Arg Glu Lys Ile Asn
      60                  65                  70

 tct aca gta aat aaa gat tta gaa aac aga aag agg tct cga agt aac      412
 Ser Thr Val Asn Lys Asp Leu Glu Asn Arg Lys Arg Ser Arg Ser Asn
  75                  80                  85                  90

 agc cat tca gat cat atc aga cga gga aga gga aga cct aaa agt gca      460
 Ser His Ser Asp His Ile Arg Arg Gly Arg Gly Arg Pro Lys Ser Ala
                  95                 100                 105

 tct gcc aaa aaa cat gag gaa gaa aga gag aaa cag gaa aag gaa att      508
 Ser Ala Lys Lys His Glu Glu Glu Arg Glu Lys Gln Glu Lys Glu Ile
             110                 115                 120

 gac atc tat gct aac ctg tct gat gaa aag gct ttc gtg ttt tca gtc      556
 Asp Ile Tyr Ala Asn Leu Ser Asp Glu Lys Ala Phe Val Phe Ser Val
         125                 130                 135

 gcc ttg gca gaa ata aat aga aaa att atc aat caa aga ctt att ctc      604
 Ala Leu Ala Glu Ile Asn Arg Lys Ile Ile Asn Gln Arg Leu Ile Leu
     140                 145                 150

 tga tact tgtttgcaaa atctgctgaa acttctgtca ggataacatc agcaaattct      661
 


 caaacagtta tggactctca ggagcattct gactgcatca ataaggggcc atcgaattgt    721

 gttctttctc gcctgtcgtt tagcctgtgc cacacttcgg gagcccaagc tgtgtaagct    781

 tggactgttc tgggatttcc ttgtttaaca cggaggtatg tcaggttcgt gttgggatat    841

 agtaaggtat ttgcaacaaa aaaaaaa                                        868




      <210> 102
      <211> 718
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (203)..(568)

      <400> 102
 attcgtggtt tcacccggga aaacagctcc ccggattaaa cggataggtt tacacatact     60

 gatccaccca gctattcatc ttctgtttgc tgctttaatt gggtgcggtt aaaaggccac    120

 gtccctaggc gttcaccggc tttcttgcca tctgctgcat gaaaactgac tttgccgaaa    180

 aaattaacaa agaagagcga aa atg aca gac cgc aac cgg gat aag aaa agt     232
                          Met Thr Asp Arg Asn Arg Asp Lys Lys Ser
                            1               5                  10

 act tca cct tca aat tca gac aca gaa atg aaa tct gaa caa ctg cct      280
 Thr Ser Pro Ser Asn Ser Asp Thr Glu Met Lys Ser Glu Gln Leu Pro
                  15                  20                  25

 cct tgt gtg aac cct ggc aat cct gtg ttt tca tgt atg ttg gat cca      328
 Pro Cys Val Asn Pro Gly Asn Pro Val Phe Ser Cys Met Leu Asp Pro
              30                  35                  40

 aag aca ctc cag aca gcc acc tca cta tca aaa cct caa atg att atg      376
 Lys Thr Leu Gln Thr Ala Thr Ser Leu Ser Lys Pro Gln Met Ile Met
          45                  50                  55

 tat aaa acc aat tca agt cat tat ggt gaa ttt cta cct att cca cag      424
 Tyr Lys Thr Asn Ser Ser His Tyr Gly Glu Phe Leu Pro Ile Pro Gln
      60                  65                  70

 ttt ttc ccc tgc aat tat act cca aag gag caa gta ttt tca agc cat      472
 Phe Phe Pro Cys Asn Tyr Thr Pro Lys Glu Gln Val Phe Ser Ser His
  75                  80                  85                  90

 atc aga gca act gga ttt tat caa aat aac act cta aat act gca cct      520
 Ile Arg Ala Thr Gly Phe Tyr Gln Asn Asn Thr Leu Asn Thr Ala Pro
                  95                 100                 105

 gac aga acc aga act ctt gat ttt cct aat att caa cac act cta tga      568
 Asp Arg Thr Arg Thr Leu Asp Phe Pro Asn Ile Gln His Thr Leu 
             110                 115                 120

 aaatatattc ctttgtatat tgaagagaaa atatactcgg gaaaaatgag tgttaaatct    628

 aagggtagaa tacctaataa agaagataaa aagttttgaa tcaattttta aaataagtta    688

 aataaagtat ttcaactgat aaaaaaaaaa                                     718




      <210> 103
      <211> 847
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (151)..(504)

      <220>
      <221> misc_feature
      <222> (1)...(847)
      <223> n = a,t,c or g

      <400> 103
 ctaggtgcag ctgccggatc cttcagcgtc tgcatctcgg cgtcgccccg cgtaccgtcg     60

 cccggctctc cgccgctctc ccgggggttc ggggcacttg ggtcccacag tctggtcctg    120

 cttcaccttc ccctgacctg agtagtcgcc     atg gca cag gtt ctc aga ggc     171
                                      Met Ala Gln Val Leu Arg Gly
                                        1               5

 act gtg act gac ttc cct gga ttt gat gag cgg gct gat gca aaa act      219
 Thr Val Thr Asp Phe Pro Gly Phe Asp Glu Arg Ala Asp Ala Lys Thr
          10                  15                  20

 ctt cgg aag gct atg aaa ggc ttg ggc aca gat gag gag agc atc ctg      267
 Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Glu Ser Ile Leu
      25                  30                  35

 act ctg ttg aca tcc cga agt aat gct cag cgc cag gaa atc tct gca      315
 Thr Leu Leu Thr Ser Arg Ser Asn Ala Gln Arg Gln Glu Ile Ser Ala
  40                  45                  50                  55

 gct ttt aag act ctg ttt ggc agg gat ctt ctg gat gac ctg aaa tca      363
 Ala Phe Lys Thr Leu Phe Gly Arg Asp Leu Leu Asp Asp Leu Lys Ser
                  60                  65                  70

 gaa cta act gga aaa ttt gaa aaa tta att gtg gct ctg atg aaa ccc      411
 Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile Val Ala Leu Met Lys Pro
              75                  80                  85

 tct cgg ctt tat gat gct tat gaa ctg aaa cat gcc ttg aag gga gct      459
 Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys His Ala Leu Lys Gly Ala
          90                  95                 100

 gga aca aat gaa aaa gta ctg aca gaa att att gct tca ggc taa cag      507
 Gly Thr Asn Glu Lys Val Leu Thr Glu Ile Ile Ala Ser Gly 
     105                 110                 115

 agaccctgat gctggaattg atgaagctca agttgaacaa gatgctcagg ctttatttca    567

 ggctggagaa cttaaatggg ggacagatga agaaaagttt atcaccatct ttggaacacg    627

 aagtgtgtct catttgagaa aggtgtttga caagtacatg actatatcag gatttcaaat    687

 tgaggaaacc attgaccgcg agacttcttg gcaatttaga gcaactactt ccttgctggt    747

 gngaaaacta ttcgaagtat acctggctac cttgcanaga cctttattat gctatgaang    807

 gagcttggac agatgatcat ccctattaaa agcatgggtt                          847




      <210> 104
      <211> 425
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (132)..(239)

      <400> 104
 ttcgtagcgt ctgcatctcg gcgtcgcccc gcgtaccgtc gcccggctct ccgccgctct     60

 cccgggggtt cggggcactt gggtcccaca gtctggtcct gcttcacctt cccctgacct    120

 gagtagtcgc c atg gca cag gtt ctc aga ggc act gtg act gac ttc cct     170
              Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro
                1               5                  10

 gga ttt gat gag cgg gct gat gca gaa act ctt cgg aag gct atg aaa      218
 Gly Phe Asp Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys
      15                  20                  25

 ggc ttg gga tct tct gga tga cc tgaaatcaga actaactgga aaatttgaaa      271
 Gly Leu Gly Ser Ser Gly 
  30                  35

 aattaattgt ggctctgatg aaaccctctc ggctttatga tgcttatgaa ctgaaacatg    331

 ccttgaaggg agctggaaca aatggaaaag tactgacaga aattattgct tcaaggacac    391

 ctgaagaact gagagccatc aaacaagttt atga                                425




      <210> 105
      <211> 2230
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (224)..(2128)

      <400> 105
 cggaatttcc gggtcgacga tttcgtaggc ctacgggaag ccagtcaaat acgacccctc     60

 ctttcgaggc cccatcaaga acagaagctg cacagatgtc atctgctgcg tcctcttcct    120

 gctcttcatt ctaggttaca tcgtggtggg gattgtggcc tggttgtatg gagacccccg    180

 gcaagtcctc taccccagga actctactgg ggcctactgt ggc  atg ggg gag aac     235
                                                  Met Gly Glu Asn
                                                    1

 aaa gat aag ccg tat ctc ctg tac ttc aac atc ttc agc tgc atc ctg      283
 Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu
   5                  10                  15                  20

 tcc agc aac atc atc tca gtt gct gag aac ggc cta cag tgc ccc aca      331
 Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr
                  25                  30                  35

 ccc cag gtg tgt gtg tcc tcc tgc ccg gag gac cca tgg act gtg gga      379
 Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly
              40                  45                  50

 aaa aac gag ttc tca cag act gtt ggg gaa gtc ttc tat aca aaa aac      427
 Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Asn
          55                  60                  65

 agg aac ttt tgt ctg cca ggg gta ccc tgg aat atg acg gtg atc aca      475
 Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr
      70                  75                  80

 agc ctg caa cag gaa ctc tgc ccc agt ttc ctc ctc ccc tct gct cca      523
 Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro
  85                  90                  95                 100

 gct ctg gga cgc tgc ttt cca tgg acc aac att act cca ccg gcg ctc      571
 Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Ile Thr Pro Pro Ala Leu
                 105                 110                 115

 cca ggg atc acc aat gac acc acc ata cag cag ggg atc agc ggt ctt      619
 Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu
             120                 125                 130

 att gac agc ctc aat gcc cga gac atc agt gtt aag atc ttt gaa gat      667
 Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp
         135                 140                 145

 ttt gcc cag tcc tgg tat tgg att ctt gtt gcc ctg ggg gtg gct ctg      715
 Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu
     150                 155                 160

 gtc ttg agc cta ctg ttt atc ttg ctt ctg cgc ctg gtg gct ggg ccc      763
 Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro
 165                 170                 175                 180

 ctg gtg ctg gtg ctg atc ctg gga gtg ctg ggc gtg ctg gca tac ggc      811
 Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly
                 185                 190                 195

 atc tac tac tgc tgg gag gag tac cga gtg ctg cgg gac aag ggc gcc      859
 Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala
             200                 205                 210

 tcc atc tcc cag ctg ggt ttc acc acc aac ctc agt gcc tac cag agc      907
 Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser
         215                 220                 225

 gtg cag gag acc tgg ctg gcc gcc ctg atc gtg ttg gcg gtg ctt gaa      955
 Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu Glu
     230                 235                 240

 gcc atc ctg ctg ctg gtg ctc atc ttc ctg cgg cag cgg att cgt att     1003
 Ala Ile Leu Leu Leu Val Leu Ile Phe Leu Arg Gln Arg Ile Arg Ile
 245                 250                 255                 260

 gcc atc gcc ctc ctg aag gag gcc agc aag gct gtg gga cag atg atg     1051
 Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met Met
                 265                 270                 275

 tct acc atg ttc tac cca ctg gtc acc ttt gtc ctc ctc ctc atc tgc     1099
 Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys
             280                 285                 290

 att gcc tac tgg gcc atg act gct ctg tac ctg gct aca tcg ggg caa     1147
 Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly Gln
         295                 300                 305

 ccc cag tat gtg ctc tgg gca tcc aac atc agc tcc ccc ggc tgt gag     1195
 Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys Glu
     310                 315                 320

 aaa gtg cca ata aat aca tca tgc aac ccc acg gcc cac ctt gtg aac     1243
 Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val Asn
 325                 330                 335                 340

 tcc tcg tgc cca ggg ctg atg tgc gtc ttc cag ggc tac tca tcc aaa     1291
 Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser Lys
                 345                 350                 355

 ggc cta atc caa cgt tct gtc ttc aat ctg caa atc tat ggg gtc ctg     1339
 Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val Leu
             360                 365                 370

 ggg ctc ttc tgg acc ctt aac tgg gta ctg gcc ctg ggc caa tgc gtc     1387
 Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys Val
         375                 380                 385

 ctc gct gga gcc ttt gcc tcc ttc tac tgg gcc ttc cac aag ccc cag     1435
 Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro Gln
     390                 395                 400

 gac atc cct acc ttc ccc tta atc tct gcc ttc atc cgc aca ctc cgt     1483
 Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu Arg
 405                 410                 415                 420

 tac cac act ggg tca ttg gca ttt gga gcc ctc atc ctg acc ctt gtg     1531
 Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu Val
                 425                 430                 435

 cag ata gcc cgg gtc atc ttg gag tat att gac cac aag ctc aga gga     1579
 Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg Gly
             440                 445                 450

 gtg cag aac cct gta gcc cgc tgc atc atg tgc tgt ttc aag tgc tgc     1627
 Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys Cys
         455                 460                 465

 ctc tgg tgt ctg gaa aaa ttt atc aag ttc cta aac cgc aat gca tac     1675
 Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala Tyr
     470                 475                 480

 atc atg atc gcc atc tac ggg aag aat ttc tgt gtc tca gcc aaa aat     1723
 Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys Asn
 485                 490                 495                 500

 gcg ttc atg cta ctc atg cga aac att gtc agg gtg gtc gtc ctg gac     1771
 Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu Asp
                 505                 510                 515

 aaa gtc aca gac ctg ctg ctg ttc ttt ggg aag ctg ctg gtg gtc gga     1819
 Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val Gly
             520                 525                 530

 ggc gtg ggg gtc ctg tcc ttc ttt ttt ttc tcc ggt cgc atc ccg ggg     1867
 Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro Gly
         535                 540                 545

 ctg ggt aaa gac ttt aag agc ccc cac ctc aac tat tac tgg ctg ccc     1915
 Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu Pro
     550                 555                 560

 atc atg acc tcc atc ctg ggg gcc tat gtc atc gcc agc ggc ttc ttc     1963
 Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe Phe
 565                 570                 575                 580

 agc gtt ttc ggc atg tgt gtg gac acg ctc ttc ctc tgc ttc ctg gaa     2011
 Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu
                 585                 590                 595

 gac ctg gag cgg aac aac ggc tcc ctg gac cgg ccc tac tac atg tcc     2059
 Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met Ser
             600                 605                 610

 aag agc ctt cta aag att ctg ggc aag aag aac gag gcg ccc ccg gac     2107
 Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro Asp
         615                 620                 625

 aac aag aag agg aag aag tga ca gctccggccc tgatccagga ctgcacccca     2160
 Asn Lys Lys Arg Lys Lys 
     630

 cccccaccgt ccagccatcc aacctcactt cgccttacag gtctccattt tgtggtaaaa   2220

 aaaggtttta                                                          2230




      <210> 106
      <211> 443
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (120)..(287)

      <400> 106
 gcgaacacgc cgcggtcctc gtcgtggtga gcgcagccac tcaggctggt cctgggggtg     60

 gggctgtagg ggaaagtgct aaagccgctg agtgaagtaa gaactctgct agagaggaa     119                                                                 
 atg gct gct tca tca tca tcc tcc tca gct ggt ggg gtc agt gga agt      167
 Met Ala Ala Ser Ser Ser Ser Ser Ser Ala Gly Gly Val Ser Gly Ser
   1               5                  10                  15

 tct gtc act gga tct ggt ttc agt gtc tca gac ctt gcc cca cca cgg      215
 Ser Val Thr Gly Ser Gly Phe Ser Val Ser Asp Leu Ala Pro Pro Arg
              20                  25                  30

 aaa gcc ctt ttc acc tac ccc aaa gga gct gga gag atg tta gaa ggt      263
 Lys Ala Leu Phe Thr Tyr Pro Lys Gly Ala Gly Glu Met Leu Glu Gly
          35                  40                  45

 gat ctc atg ctg ctt tct gaa taa ttggattcag atctgcaatg catattaatt     317
 Asp Leu Met Leu Leu Ser Glu 
      50                  55

 gtaaagaagc tattaagtgg attaaagatg agtttgccct gatttcagct ccacatttca    377

 tttcttgtcc ccatctcaaa atagtatctt taaaaacaag gcttgctcca gaatcagaat    437

 tgtgtg                                                               443




      <210> 107
      <211> 1089
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (275)..(766)

      <400> 107
 gtcttggctc cggatcgtgc gtgaggcggc ttcggtgaga gccggaaccg ggcgggcaga     60

 ggggcgctcg tagggttggg ggacgcctgt ggcttggctg cagcggccgg caagaccctg    120

 gaagagaccg tggctatgga aacggccaag gctgtcttgg aatgtcctga gcagccctcc    180

 gagtcgagcc tctgcccccg agtttctgag tgacctgggt tgatatagat tgaccttgtg    240

 ggcagcgaga gtcacagaca agacagcaag cagg    atg gag cac tac cgg aaa     292
                                          Met Glu His Tyr Arg Lys
                                            1               5

 gct ggc tct gta gag ctc cca gcg cct tcc cca atg ccc cag cta cct      340
 Ala Gly Ser Val Glu Leu Pro Ala Pro Ser Pro Met Pro Gln Leu Pro
              10                  15                  20

 cct gat acc ctt gag atg cgg gtc cga gat ggc agc aaa att cgc aac      388
 Pro Asp Thr Leu Glu Met Arg Val Arg Asp Gly Ser Lys Ile Arg Asn
          25                  30                  35

 ctg ctg ggg ttg gct ctg ggt cgg ttg gag ggc ggc agt gct cgg cat      436
 Leu Leu Gly Leu Ala Leu Gly Arg Leu Glu Gly Gly Ser Ala Arg His
      40                  45                  50

 gta gtg ttc tca ggt tct ggc agg gct gca gga aag gct gtc agc tgc      484
 Val Val Phe Ser Gly Ser Gly Arg Ala Ala Gly Lys Ala Val Ser Cys
  55                  60                  65                  70

 gct gag att gtc aag cgg cgg gtc cca ggc ctg cac cag ctc acc aag      532
 Ala Glu Ile Val Lys Arg Arg Val Pro Gly Leu His Gln Leu Thr Lys
                  75                  80                  85

 cta cgt ttc ctt cag act gag gac agc tgg gtc cca gcc tca cct gac      580
 Leu Arg Phe Leu Gln Thr Glu Asp Ser Trp Val Pro Ala Ser Pro Asp
              90                  95                 100

 aca ggg cta gac ccc ctc aca gtg cgc cgc cat gtg cct gca gtg tgg      628
 Thr Gly Leu Asp Pro Leu Thr Val Arg Arg His Val Pro Ala Val Trp
         105                 110                 115

 gtg ctg ctc agc cgg gac ccc ctg gac ccc aat gag tgt ggt tac caa      676
 Val Leu Leu Ser Arg Asp Pro Leu Asp Pro Asn Glu Cys Gly Tyr Gln
     120                 125                 130

 ccc cca gga gca ccc cct ggc ctg ggt tcc atg ccc agc tcc agc tgt      724
 Pro Pro Gly Ala Pro Pro Gly Leu Gly Ser Met Pro Ser Ser Ser Cys
 135                 140                 145                 150

 ggc cct cgt tcc cga aga agg gct cga gac acc cga tcg tga agacctg      773
 Gly Pro Arg Ser Arg Arg Arg Ala Arg Asp Thr Arg Ser 
                 155                 160

 ctgagccagc ctgttctccg ggcctgaatg tctggggtgc ttgtgccttt tctgagaagc    833

 gttgtgactg ctcaacatcc ccatcaaggt ttgagtccac aaaagtggac ctccctatca    893

 tgcttcccct tccctctagc atgtgggaag ggactgctgt gaagaatgac agatgtgggg    953

 cctctgccaa gttctgcatt gctaaataag ggcttcctct gccttctacc tacagtgcat   1013

 ttgaactgcc ttctgaaaga ggtccaggga gggatttagg aaataaagtt tctacctatt   1073

 tgaaaaaaaa aaaaaa                                                   1089




      <210> 108
      <211> 1836
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (100)..(516)

      <400> 108
 ccatcctgcc cagtctccgc ttccccgtct tgtacacccc taactcctga ggctcctccg     60

 aatcacgcga gtggaagcgg agaagctcaa gtggccgcc   atg tca gag gct tat     114
                                              Met Ser Glu Ala Tyr
                                                1               5

 ttc cga gtg gag tcg ggt gcg ctg ggg cct gag gag aac ttt ctt tct      162
 Phe Arg Val Glu Ser Gly Ala Leu Gly Pro Glu Glu Asn Phe Leu Ser
                  10                  15                  20

 ttg gac gac atc ctg atg tcc cac gag aag ctg ccg gtg cgc acg gag      210
 Leu Asp Asp Ile Leu Met Ser His Glu Lys Leu Pro Val Arg Thr Glu
              25                  30                  35

 acc gcc atg cct cgc ctt ggc gct ttc ttc ctg gag cgg agc gca ggc      258
 Thr Ala Met Pro Arg Leu Gly Ala Phe Phe Leu Glu Arg Ser Ala Gly
          40                  45                  50

 gcc gag act gac aac gcg gtc cca cag act ttt atc gga cgt ttt cgc      306
 Ala Glu Thr Asp Asn Ala Val Pro Gln Thr Phe Ile Gly Arg Phe Arg
      55                  60                  65

 cgc atc atg gac tcc tca cag aat gct tac aac gaa gac act tca gcc      354
 Arg Ile Met Asp Ser Ser Gln Asn Ala Tyr Asn Glu Asp Thr Ser Ala
  70                  75                  80                  85

 ctg gta gcc agg cta gac gag atg gag agg ggc tta ttt caa aca ggg      402
 Leu Val Ala Arg Leu Asp Glu Met Glu Arg Gly Leu Phe Gln Thr Gly
                  90                  95                 100

 cag aaa gga ctg aat gac ttt cag tgt tgg gag aag ggg cag gct tct      450
 Gln Lys Gly Leu Asn Asp Phe Gln Cys Trp Glu Lys Gly Gln Ala Ser
             105                 110                 115

 cag atc aca gct tcc aac ctc gtt cag aat tac aag aag aga aaa ttc      498
 Gln Ile Thr Ala Ser Asn Leu Val Gln Asn Tyr Lys Lys Arg Lys Phe
         120                 125                 130

 act gat atg gaa gac tga aagccg gaagaacaca gaatggctcc tcacagacgt      552
 Thr Asp Met Glu Asp 
     135

 atccctccgt gtgtccttga taggagctgg ttgaccttgt acagaaccag aatcctgtcc    612

 catttcatgg cttatttcct gtggccatag agaattatag ggaactggac atgctggagg    672

 atgtgggtgt ccctggctct gtgagtcttc caggaccgtc ccaccctgct gacccacagc    732

 ccaggccctt taacccaaga acccatggcc aaggagaaat caaagtcctt cctaaataag    792

 aatcactgcc atataatata tcacagtaga gttgcaactg agattccttg tgtctgggag    852

 tttggacagc ttcagatgta cagtttcact agccacaaag cacaggtaca aactgggtca    912

 tcgcctgttc acaaaatgct ctcttgatct tatttgcctc atcttcctca tggttgtaca    972

 gaggatagca ccccaccatg ccagcctgac ttggagatat ctcctgctgc ctgcctgcag   1032

 ggagttaccc cagtttccaa aaacagtcgc ccagataaag gaggaaaagg gaaaggcaga   1092

 cgaatggcat ggcttttact aaagaaaaga tgttggcctc atactctata ctcagggctt   1152

 aatgaactgg aatctgcata actcagcagt caacccagaa gggaaatggt taaactgagc   1212

 ttgttattgc ctcggagagc ctaagagcac ccgcacactt aattctactc cctgtctaga   1272

 aaagctgtca gggagtcgtt tggaattgca atgtagttat taagggctgt taaccagcct   1332

 gcattacatc tggaagtcag gacttgggtg ctgactatga agggccctgt tttcaaaatc   1392

 taacattgca agtgtaaatg ggcaagaagc ctccgttgtg cttttttttt cctcttcagt   1452

 aacttttgca acattattgc atagaagatc cctgaccatt tactaggaac ctggttaagc   1512

 aagcactaat ctcttttcct ggagatcaag gatgcaacct caggttgaga aagaaacagg   1572

 gttccctggg cccattagac tgtttgcagg gcatcactgc ttccccctga cacctcacaa   1632

 ctagcaaaaa ttgtctttgt ctttggaaat tatagaggga tttgggtatc cagattgtgc   1692

 agatgcaaac ttaggctgtc ttgatgcaaa cttagaacca cagaaatgct tttaaaatgc   1752

 ctgttttaag atggaattgt tgtttttata atttgatttt agtgctaaat aaatgattgg   1812

 ctttgtacat gaaaaaaaaa aaaa                                          1836




      <210> 109
      <211> 1228
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (650)..(880)

      <400> 109
 cccgggtcga cgatttcgta gcgactcctc cgccgccttt gttgttctcg gttccccggc     60

 ttcccctgca ccgggaaagc gccccgtctc gagaggctgg tgcctggaga actgcgaacg    120

 agctgcagaa aaccagattt taaaatgtag aagtcgttgg gctgcattcc tccgaggacc    180

 agtctgatcg cccaggatta agagtggcag cgtatgagaa gttgggacca taaagcaagg    240

 gggggagggg agtgttgcag caggcattct cttctggaag gagtcgctgg gagcagtgcg    300

 gttggacaca agtttgcgta ggagtgtttt ccttttgtca ataattaatc accggaatta    360

 gccaggtaga atttgagttt tagcaagagt cctgagggcg gggccgaaca cctaactccg    420

 ggaggctccc aggcgcccgg cgcagtggga agctcgcagc agctggggag gagccaaagc    480

 ctctgcgctc acctaagccg cagggagata cacccaactg ggagatgagg aaacagcaac    540

 ccagagagga gaactaaccc acacaggatc atttcgcgaa ggagcaaggc tgaagaacca    600

 gacctggact ttcttaggac aaacttactg cagcttgaag gagccaacc    atg gat     655
                                                          Met Asp
                                                            1

 ttg agg cgt gtg aag gaa tat ttc tcc tgg ctc tac tat caa tac caa      703
 Leu Arg Arg Val Lys Glu Tyr Phe Ser Trp Leu Tyr Tyr Gln Tyr Gln
           5                  10                  15

 atc att agc tgc tgt gct gtt tta gag ccc tgg gag cga tct atg ttt      751
 Ile Ile Ser Cys Cys Ala Val Leu Glu Pro Trp Glu Arg Ser Met Phe
      20                  25                  30

 aac acc atc tta cta acc att att gct atg gtg gta tac act gcc tat      799
 Asn Thr Ile Leu Leu Thr Ile Ile Ala Met Val Val Tyr Thr Ala Tyr
  35                  40                  45                  50

 gtc ttt att cca atc cac att cgc ctg gct tgg gaa ttt ttc tca aaa      847
 Val Phe Ile Pro Ile His Ile Arg Leu Ala Trp Glu Phe Phe Ser Lys
                  55                  60                  65

 ata tgt gga tat cac agt aca att tct aat tga tcctgttc acattcagtg      898
 Ile Cys Gly Tyr His Ser Thr Ile Ser Asn 
              70                  75

 aaatggcatt gcatatttat atgttgctta cagcttattg atttaggtaa ctattgtgtc    958

 ttccttcact atctgacctg aaaagcactc tcttctctat gcactcttat attctgcctt   1018

 tctgcctgga gtttgaaata catgtctctt tagtttcttt tgcacatgct acattgtgct   1078

 ttagaccgga gataatacag tgactttacc tcacaaatca tattctgtca acacaaatct   1138

 atgaatttag tttatttaaa atcagaacaa tttcctacaa aatttttctg gaaaatagac   1198

 tcctaacaga cctaccagaa tcatgcttaa                                    1228




      <210> 110
      <211> 1304
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1257)

      <400> 110
  atg ttt tct cct gat caa gaa aat cat cca tct aaa gca cca gta aaa      48
  Met Phe Ser Pro Asp Gln Glu Asn His Pro Ser Lys Ala Pro Val Lys
    1               5                  10                  15

 tat ggt gaa ctc att gtc tta ggg tat aat ggg tct ctc cca aat ggc       96
 Tyr Gly Glu Leu Ile Val Leu Gly Tyr Asn Gly Ser Leu Pro Asn Gly
              20                  25                  30

 gat aga gga agg agg aaa agt agg ttt gct ttg ttt aaa aga cct aag      144
 Asp Arg Gly Arg Arg Lys Ser Arg Phe Ala Leu Phe Lys Arg Pro Lys
          35                  40                  45

 gca aat ggg gtg aag ccc agc act gtg cat att gct tgt act cct cag      192
 Ala Asn Gly Val Lys Pro Ser Thr Val His Ile Ala Cys Thr Pro Gln
      50                  55                  60

 gct gca aag gca ata agc aac aaa gac cag cat agc ata tca tat act      240
 Ala Ala Lys Ala Ile Ser Asn Lys Asp Gln His Ser Ile Ser Tyr Thr
  65                  70                  75                  80

 ttg tct cgg gcc cag act gtg gtg gtt gaa tat act cat gac agc aac      288
 Leu Ser Arg Ala Gln Thr Val Val Val Glu Tyr Thr His Asp Ser Asn
                  85                  90                  95

 aca gat atg ttt cag att ggc cgg tcg act gaa agc ccc att gat ttt      336
 Thr Asp Met Phe Gln Ile Gly Arg Ser Thr Glu Ser Pro Ile Asp Phe
             100                 105                 110

 gta gta act gac acg gtt cct gga agt caa agt aat tct gat aca cag      384
 Val Val Thr Asp Thr Val Pro Gly Ser Gln Ser Asn Ser Asp Thr Gln
         115                 120                 125

 tca gta caa agc act ata tca aga ttt gcc tgc aga atc ata tgt gaa      432
 Ser Val Gln Ser Thr Ile Ser Arg Phe Ala Cys Arg Ile Ile Cys Glu
     130                 135                 140

 cgg aat cct ccc ttt aca gca cgg att tat gct gca gga ttt gac tca      480
 Arg Asn Pro Pro Phe Thr Ala Arg Ile Tyr Ala Ala Gly Phe Asp Ser
 145                 150                 155                 160

 tca aaa aac atc ttt ctt ggg gag aag gct gcc aaa tgg aag aca tca      528
 Ser Lys Asn Ile Phe Leu Gly Glu Lys Ala Ala Lys Trp Lys Thr Ser
                 165                 170                 175

 gat gga cag atg gat ggc ttg acc act aat ggt gtt ctt gtg atg cat      576
 Asp Gly Gln Met Asp Gly Leu Thr Thr Asn Gly Val Leu Val Met His
             180                 185                 190

 cca cgc aat ggg ttc aca gaa gac tcc aag cct gga ata tgg aga gaa      624
 Pro Arg Asn Gly Phe Thr Glu Asp Ser Lys Pro Gly Ile Trp Arg Glu
         195                 200                 205

 ata tcg gtg tgt gga aat gta ttt agc cta cgt gaa acc aga tcg gct      672
 Ile Ser Val Cys Gly Asn Val Phe Ser Leu Arg Glu Thr Arg Ser Ala
     210                 215                 220

 cag cag aga gga aaa atg gtg gaa att gaa acc aat cag tta caa gat      720
 Gln Gln Arg Gly Lys Met Val Glu Ile Glu Thr Asn Gln Leu Gln Asp
 225                 230                 235                 240

 ggc tcg tta att gac ctc tgt ggt gca aca ttg tta tgg cgt act gca      768
 Gly Ser Leu Ile Asp Leu Cys Gly Ala Thr Leu Leu Trp Arg Thr Ala
                 245                 250                 255

 gaa ggc ctt tcc cac act cct acc gtg aag cat tta gaa gct tta aga      816
 Glu Gly Leu Ser His Thr Pro Thr Val Lys His Leu Glu Ala Leu Arg
             260                 265                 270

 cag gaa atc aat gca gca cga cct cag tgc cct gta ggg ttc aac aca      864
 Gln Glu Ile Asn Ala Ala Arg Pro Gln Cys Pro Val Gly Phe Asn Thr
         275                 280                 285

 cta gca ttt cct agt atg aag agg aaa gac gtt gta gat gaa aaa caa      912
 Leu Ala Phe Pro Ser Met Lys Arg Lys Asp Val Val Asp Glu Lys Gln
     290                 295                 300

 cca tgg gta tat cta aac tgc ggc cat gta cat ggc tat cat aac tgg      960
 Pro Trp Val Tyr Leu Asn Cys Gly His Val His Gly Tyr His Asn Trp
 305                 310                 315                 320

 gga aac aaa gaa gaa cgt gat gga aaa gat cgt gaa tgt cct atg tgt     1008
 Gly Asn Lys Glu Glu Arg Asp Gly Lys Asp Arg Glu Cys Pro Met Cys
                 325                 330                 335

 agg tct gtt ggt ccc tat gtt cct ctg tgg ctt gga tgt gaa gct gga     1056
 Arg Ser Val Gly Pro Tyr Val Pro Leu Trp Leu Gly Cys Glu Ala Gly
             340                 345                 350

 ttt tat gtg gac gcc ggc cct cca acc cat gcg ttt agc ccg tgt ggg     1104
 Phe Tyr Val Asp Ala Gly Pro Pro Thr His Ala Phe Ser Pro Cys Gly
         355                 360                 365

 cat gtg tgt tca gaa aag aca act gcc tat tgg tcc cag atc cca ctt     1152
 His Val Cys Ser Glu Lys Thr Thr Ala Tyr Trp Ser Gln Ile Pro Leu
     370                 375                 380

 cct cat ggt act cat act ttt cat gca gcc tgt ccc ttt tgt gca cat     1200
 Pro His Gly Thr His Thr Phe His Ala Ala Cys Pro Phe Cys Ala His
 385                 390                 395                 400

 cag ttg gct ggt gaa caa ggc tac atc aga ctt att ttt caa gga cct     1248
 Gln Leu Ala Gly Glu Gln Gly Tyr Ile Arg Leu Ile Phe Gln Gly Pro
                 405                 410                 415

 cta gac taa cagacca ttgtcttgca ggactacatt ataaatttat aagctaagtg     1304
 Leu Asp 






      <210> 111
      <211> 1084
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (828)..(1037)

      <400> 111
 aagcctgaag actcgcccca cccaccactg cccagcaccc aatgtcctcc cgtgcccctc     60

 cccgctgtcc tcttggcccc aggggagaag atgaggccat cagagatggc caggagaagg    120

 gccaggggaa tagagctatt tttttaacaa aacaaaatga agacaaaaat atggactgat    180

 gtatcctcgc ctggactcag ggcaggtgcc gtgggttctc cagagacccc agcacctggc    240

 ccaggatgca ggctgctcta gagaccaaag gaacaccagg cccagcgccc tctttggtcc    300

 agccagaccc tgggccctct ctcctcactg caccaggacc tgatgccaag aaagtgagga    360

 tttaggcaac aaggaggcaa aagcaaatct caaagaagtc atcaaagccc aggggctgca    420

 cggagattca gctgccatgt ctttgaggac ctcgaaccca cagcgcaatc cctggtccac    480

 tggaggatgg actgttcccc ccttcaggcc ggggccaaga gtgagctgct aacacggcat    540

 ccaagaatgg cccagctggt aggatccttg ctttccccat ctgttggacc aaataatctc    600

 aaaggcccag agaggacagt gaccatccac agacacacag cacaggcgtg acagttctga    660

 aaagaagctg agttgtctcc aggctgctgt cactgcatcc aggactctgt cagctctgct    720

 gcccacatgc acccctggcc tcagcatccc ggttccccca gacaagagag ggcaagtcag    780

 ccaggaactg cctcctccct gctctacagc taagaaaaca ccattcc  atg act tcc     836
                                                      Met Thr Ser
                                                        1

 cac cgc gcc ctc gct cct acc tcc cca cac ctc tct ctg agt ccc cag      884
 His Arg Ala Leu Ala Pro Thr Ser Pro His Leu Ser Leu Ser Pro Gln
       5                  10                  15

 gaa cac aca gag gtg cac atc aca ttc cct tgt cca cac tgc ccg cct      932
 Glu His Thr Glu Val His Ile Thr Phe Pro Cys Pro His Cys Pro Pro
  20                  25                  30                  35

 ctc cca cat gcc acc ccc ttc cct gtc ctt ccc caa ctc ccc agc tcc      980
 Leu Pro His Ala Thr Pro Phe Pro Val Leu Pro Gln Leu Pro Ser Ser
                  40                  45                  50

 aag agt gga aga aat ccc caa gat cat ctg ggt ctc cct ctc cac acc     1028
 Lys Ser Gly Arg Asn Pro Gln Asp His Leu Gly Leu Pro Leu His Thr
              55                  60                  65

 cag aac tga ggcttgg atatcttctt caacatcctt gccaagactt ctccaccctc     1084
 Gln Asn 






      <210> 112
      <211> 866
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (204)..(824)

      <400> 112
 gataacatag tgagctctct gcctcttcgg aacgatgtcc actttgctta tgatcaaccc     60

 aagcaggact cttctctccc tggacgcctc tcccctggtc tggaatcttc cagttctgcc    120

 agaattggcc tttcccagat gctgcaaact tccagttgaa cccctttttc tgtgtggccc    180

 ctggggctgc gagaccaaaa tcc    atg agt tct gtg tac cct aga cct ttg     230
                              Met Ser Ser Val Tyr Pro Arg Pro Leu
                                1               5

 gaa ggt gag agc agg gcc ctg aga aaa ggc agc cac ctc ctc tcc ctg      278
 Glu Gly Glu Ser Arg Ala Leu Arg Lys Gly Ser His Leu Leu Ser Leu
  10                  15                  20                  25

 gct gaa ccc ctg cca ccc tac tcc tca cca gaa ttg tca gtg gcc ttt      326
 Ala Glu Pro Leu Pro Pro Tyr Ser Ser Pro Glu Leu Ser Val Ala Phe
                  30                  35                  40

 cac cac agt ggt cct tcc tgc ctg agc cct gca ctg tcc cag acc aca      374
 His His Ser Gly Pro Ser Cys Leu Ser Pro Ala Leu Ser Gln Thr Thr
              45                  50                  55

 cag aag tct ggt cac ctc tgg gcg cct ggg atg gtc acc gaa gag aag      422
 Gln Lys Ser Gly His Leu Trp Ala Pro Gly Met Val Thr Glu Glu Lys
          60                  65                  70

 cac gct gtc ccc gtc tct cct ggc ttc tgc cag aaa atc gaa caa gtg      470
 His Ala Val Pro Val Ser Pro Gly Phe Cys Gln Lys Ile Glu Gln Val
      75                  80                  85

 caa tta aca cac tgt tac tgc cga agc ctg aaa ctc cca gga ctt gtc      518
 Gln Leu Thr His Cys Tyr Cys Arg Ser Leu Lys Leu Pro Gly Leu Val
  90                  95                 100                 105

 ctt gat cct tcc aga aac cac cag gtc cgg cac ttg gag ccc ccc gga      566
 Leu Asp Pro Ser Arg Asn His Gln Val Arg His Leu Glu Pro Pro Gly
                 110                 115                 120

 gag gga cct ccc agc cga gcc ctc aaa gaa ctc cat gaa atc agg aac      614
 Glu Gly Pro Pro Ser Arg Ala Leu Lys Glu Leu His Glu Ile Arg Asn
             125                 130                 135

 tgc ttg atg aaa tgt atc tcc ttg tac ctg gaa gat gaa gcc caa aca      662
 Cys Leu Met Lys Cys Ile Ser Leu Tyr Leu Glu Asp Glu Ala Gln Thr
         140                 145                 150

 ccc aca cct ctg tct ccc cca ggg ctc ggg atg tct cca gca gcc cgg      710
 Pro Thr Pro Leu Ser Pro Pro Gly Leu Gly Met Ser Pro Ala Ala Arg
     155                 160                 165

 cca cgc agc ttc cca ggt ggg ctc ggg gag gtg gga gca ggg acc atc      758
 Pro Arg Ser Phe Pro Gly Gly Leu Gly Glu Val Gly Ala Gly Thr Ile
 170                 175                 180                 185

 tct gtc ccc tcc acc ctc act cca tcc acc tcg gag acc acc ctc ccc      806
 Ser Val Pro Ser Thr Leu Thr Pro Ser Thr Ser Glu Thr Thr Leu Pro
                 190                 195                 200

 cag cca gat acg gaa taa aactac agacgcagac gtcggaaaaa aaaaaaaaaa      860
 Gln Pro Asp Thr Glu 
             205

 aaaaaa                                                               866




      <210> 113
      <211> 424
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(412)

      <400> 113
 gagtccgcgg ttttgctaag aagccgcagt g   atg ttg acg cgg ctg gtc ctc      52
                                      Met Leu Thr Arg Leu Val Leu
                                        1               5

 agt gca cac ctg agt agc acg acc tct ccg ccc tgg acg cac gct gcc      100
 Ser Ala His Leu Ser Ser Thr Thr Ser Pro Pro Trp Thr His Ala Ala
          10                  15                  20

 atc agc tgg gag ctg gac aac gtg ctg atg cct agt ccc aga atc tgg      148
 Ile Ser Trp Glu Leu Asp Asn Val Leu Met Pro Ser Pro Arg Ile Trp
      25                  30                  35

 ccc cag gtg act cca aca gct ggg cag gat gtg cat gcc ata gta acc      196
 Pro Gln Val Thr Pro Thr Ala Gly Gln Asp Val His Ala Ile Val Thr
  40                  45                  50                  55

 aga acc tgt gag tct gtg ctg agc tct gcc gtc tac acc cac ggc tgt      244
 Arg Thr Cys Glu Ser Val Leu Ser Ser Ala Val Tyr Thr His Gly Cys
                  60                  65                  70

 ggc tgt gtg agg tct gcc aca aac att acc tgt cag tcc tca gga caa      292
 Gly Cys Val Arg Ser Ala Thr Asn Ile Thr Cys Gln Ser Ser Gly Gln
              75                  80                  85

 caa agg cag gcg gcc cgg cag gaa gag gag aac tca atc tgc aag gcc      340
 Gln Arg Gln Ala Ala Arg Gln Glu Glu Glu Asn Ser Ile Cys Lys Ala
          90                  95                 100

 cat gat agt aga gag ggc cgc ctg ggc tac ccc ctc agt gcc cat cag      388
 His Asp Ser Arg Glu Gly Arg Leu Gly Tyr Pro Leu Ser Ala His Gln
     105                 110                 115

 cct ggt tcc ggt ggt cct aac taa ccctgtctcc tt                        424
 Pro Gly Ser Gly Gly Pro Asn 
 120                 125





      <210> 114
      <211> 2094
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (394)..(1695)

      <400> 114
 cttacacatg aggaaattga tgcttagcaa catgaggtaa ctttctcaag accacatggc     60

 taaaaagtgg aggcatgact tccagctaca gcactgatat agaatataca gtttcagatg    120

 ataagtttta gatgatgctt ttaatggaaa tttggtgaca tccatacaag ttctcgtctt    180

 catctttttg ccttttcttt ttccatggga ttttgagtga ggattttcat cttcaaagat    240

 gttagagaca gaatgttcaa acactttaaa aatttaacat taatttaaat ttataagaaa    300

 cctaaaatag ctatttcctc aagttgttat ttccaactct ccaggtggac tccaaatcac    360

 tacgtaatca tcgagaaaag acttttatta gat atg ttc ctg ctg ggt tta gaa     414
                                      Met Phe Leu Leu Gly Leu Glu
                                        1               5

 aat cct ata tct tct gtt gat aca gca agt gct atg tct ctg gaa gaa      462
 Asn Pro Ile Ser Ser Val Asp Thr Ala Ser Ala Met Ser Leu Glu Glu
          10                  15                  20

 tgg ttt gct ggt agt gga tgt acc ttt gta gac act ctt caa ttc tct      510
 Trp Phe Ala Gly Ser Gly Cys Thr Phe Val Asp Thr Leu Gln Phe Ser
      25                  30                  35

 gcc ctc ctt cgt gga gcc tct aga gaa atg ctt ctc agt gtg act agc      558
 Ala Leu Leu Arg Gly Ala Ser Arg Glu Met Leu Leu Ser Val Thr Ser
  40                  45                  50                  55

 tcc tac atc agg cta ttt gcc gaa gga ata tac gga cta gcg gcc cga      606
 Ser Tyr Ile Arg Leu Phe Ala Glu Gly Ile Tyr Gly Leu Ala Ala Arg
                  60                  65                  70

 cca ctc ctc gcc cct ccc cta cca ctg ccg cgc aca tat tac gca tta      654
 Pro Leu Leu Ala Pro Pro Leu Pro Leu Pro Arg Thr Tyr Tyr Ala Leu
              75                  80                  85

 agc agg cgc cgc gag tac gga cat cgc gag cgc ctg cgc gaa ggg cta      702
 Ser Arg Arg Arg Glu Tyr Gly His Arg Glu Arg Leu Arg Glu Gly Leu
          90                  95                 100

 cgc atg cgc aga ggg gcc agc ccg ctg aca gat tct cgg tgg cgg cgg      750
 Arg Met Arg Arg Gly Ala Ser Pro Leu Thr Asp Ser Arg Trp Arg Arg
     105                 110                 115

 cag cgg cgg cgg ccc tgg act gcg ggg aat ggg aat cct agg tcc ctg      798
 Gln Arg Arg Arg Pro Trp Thr Ala Gly Asn Gly Asn Pro Arg Ser Leu
 120                 125                 130                 135

 act gag cac ctc ccc cgc ctc cct gcc ccc gac atg gct cag gag aag      846
 Thr Glu His Leu Pro Arg Leu Pro Ala Pro Asp Met Ala Gln Glu Lys
                 140                 145                 150

 atg gag cta gac ctg gag ctg cct ccg ggt acg ggc ggg agc ccg gcg      894
 Met Glu Leu Asp Leu Glu Leu Pro Pro Gly Thr Gly Gly Ser Pro Ala
             155                 160                 165

 gag ggc ggt ggc agc ggc ggc ggc ggg ggc ctc agg agg tct aac agc      942
 Glu Gly Gly Gly Ser Gly Gly Gly Gly Gly Leu Arg Arg Ser Asn Ser
         170                 175                 180

 gcc ccc ctg atc cac ggc ctc agt gac act tcg ccg gtg ttc cag gcc      990
 Ala Pro Leu Ile His Gly Leu Ser Asp Thr Ser Pro Val Phe Gln Ala
     185                 190                 195

 gag gcg ccg agc gcc agg cgg aac agc aca acg ttc ccg agc cgc cac     1038
 Glu Ala Pro Ser Ala Arg Arg Asn Ser Thr Thr Phe Pro Ser Arg His
 200                 205                 210                 215

 ggc ctg ctg ctg ccg gcc tcc cct gtc cgc atg cac agc agc cgc ttg     1086
 Gly Leu Leu Leu Pro Ala Ser Pro Val Arg Met His Ser Ser Arg Leu
                 220                 225                 230

 cac cag atc aaa caa gaa gag ggc atg gac ttg atc aac cga gag acg     1134
 His Gln Ile Lys Gln Glu Glu Gly Met Asp Leu Ile Asn Arg Glu Thr
             235                 240                 245

 gtc cac gaa cgg gag gtg cag acc gca atg cag ata agc cac tcc tgg     1182
 Val His Glu Arg Glu Val Gln Thr Ala Met Gln Ile Ser His Ser Trp
         250                 255                 260

 gag gaa agt ttc agc ctg agt gac aac gac gtg gag aaa tcc gcc tcc     1230
 Glu Glu Ser Phe Ser Leu Ser Asp Asn Asp Val Glu Lys Ser Ala Ser
     265                 270                 275

 ccc aag cgc atc gat ttc att cct gtg tca cca gca ccg tca ccc act     1278
 Pro Lys Arg Ile Asp Phe Ile Pro Val Ser Pro Ala Pro Ser Pro Thr
 280                 285                 290                 295

 cgg gga att ggg aag cag tgt ttt tcg cca tcc ttg caa agt ttt gta     1326
 Arg Gly Ile Gly Lys Gln Cys Phe Ser Pro Ser Leu Gln Ser Phe Val
                 300                 305                 310

 agt agc aac gga ttg cct cca agc cct att ccc agc cca acg acc cga     1374
 Ser Ser Asn Gly Leu Pro Pro Ser Pro Ile Pro Ser Pro Thr Thr Arg
             315                 320                 325

 ttt acc acc cgg aga agc cag agc ccc atc aat tgc att aga cca agt     1422
 Phe Thr Thr Arg Arg Ser Gln Ser Pro Ile Asn Cys Ile Arg Pro Ser
         330                 335                 340

 gtt ctt gga cca ttg aaa aga aaa tgt gaa atg gaa act gaa tat cag     1470
 Val Leu Gly Pro Leu Lys Arg Lys Cys Glu Met Glu Thr Glu Tyr Gln
     345                 350                 355

 cca aag aga ttt ttc cag ggc atc acc aac atg ctt tct tct gac gtt     1518
 Pro Lys Arg Phe Phe Gln Gly Ile Thr Asn Met Leu Ser Ser Asp Val
 360                 365                 370                 375

 gca cag ctg tca gat cct ggt gtg tgt gta tct tcg gat acc ctt gat     1566
 Ala Gln Leu Ser Asp Pro Gly Val Cys Val Ser Ser Asp Thr Leu Asp
                 380                 385                 390

 gga aac agc agc agt gcc gga tct tct tgt aac tca cca gcg aaa gtc     1614
 Gly Asn Ser Ser Ser Ala Gly Ser Ser Cys Asn Ser Pro Ala Lys Val
             395                 400                 405

 agc act acc acc gac tct cct gtg tca cct gcc caa gcg gct tct cca     1662
 Ser Thr Thr Thr Asp Ser Pro Val Ser Pro Ala Gln Ala Ala Ser Pro
         410                 415                 420

 ttt att cca cta gat gaa ctt tcg tct aag tga ttcactca tcctgagact     1713
 Phe Ile Pro Leu Asp Glu Leu Ser Ser Lys 
     425                 430

 ttctttttgc agtggagaga gagaataatc tagttggggc aaacactgaa ctttgtcaat   1773

 taatttgagg ctatttccta tttgacccct tttctttttt gaaattccct gaaatgatgt   1833

 tattctagag aacttctatg tcaggttcct ttggataccc ttgaattcag tgtagtaata   1893

 ttttcagacg tttccccaat aagtgtgttg aagcatacat ctttacgctg ctaatatgtc   1953

 taaatacata tgttatccct tgattttttt aaataactga gagctctatt tatttatggg   2013

 attattaagt tctgatgaaa atataaatgt tgacttaatc agcatagtaa actgatgttt   2073

 aaaattccat aaaaaaaaaa a                                             2094




      <210> 115
      <211> 1377
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(1247)

      <400> 115
 agaacttcca tcaatcactg gtgaatcatc acttgttggg aaagaagcat actctacaga     60

 ggctgatc atg gag caa aaa cag caa ctt ttt ctc cag cat cag atg ctg     110
          Met Glu Gln Lys Gln Gln Leu Phe Leu Gln His Gln Met Leu
            1               5                  10

 gct gac gcg gag aaa att gct cca caa gat cag ata aac cga cat ttg      158
 Ala Asp Ala Glu Lys Ile Ala Pro Gln Asp Gln Ile Asn Arg His Leu
  15                  20                  25                  30

 tca agg cca cct cca gat tat aaa gac caa aga aga aat gtg ggc aat      206
 Ser Arg Pro Pro Pro Asp Tyr Lys Asp Gln Arg Arg Asn Val Gly Asn
                  35                  40                  45

 atg caa cca act gct cag tat tct ggt ggc tca tcc aca ata agc tta      254
 Met Gln Pro Thr Ala Gln Tyr Ser Gly Gly Ser Ser Thr Ile Ser Leu
              50                  55                  60

 aac tct aac cag gct ttg gca aac cca gtt tca aca cac acc att tta      302
 Asn Ser Asn Gln Ala Leu Ala Asn Pro Val Ser Thr His Thr Ile Leu
          65                  70                  75

 act ccc aat tcc agc ctc ctg tct act tct cac ggg aca aga atg cca      350
 Thr Pro Asn Ser Ser Leu Leu Ser Thr Ser His Gly Thr Arg Met Pro
      80                  85                  90

 tca tta tct aca gca gtt cag aat atg ggg atg tat gga aat ctg cct      398
 Ser Leu Ser Thr Ala Val Gln Asn Met Gly Met Tyr Gly Asn Leu Pro
  95                 100                 105                 110

 tgt aat caa cct aac aca tac agt gtc act tca gga atg aat caa ttg      446
 Cys Asn Gln Pro Asn Thr Tyr Ser Val Thr Ser Gly Met Asn Gln Leu
                 115                 120                 125

 acc caa cag aga aac cca aag caa ttg tta gca aat caa aac aac cct      494
 Thr Gln Gln Arg Asn Pro Lys Gln Leu Leu Ala Asn Gln Asn Asn Pro
             130                 135                 140

 atg atg cca cgg cca cct acc tta ggg cca agt aat aat aac aat gta      542
 Met Met Pro Arg Pro Pro Thr Leu Gly Pro Ser Asn Asn Asn Asn Val
         145                 150                 155

 gcc act ttt gga gct gga tct gtt ggt aat tca caa caa ttg aga cca      590
 Ala Thr Phe Gly Ala Gly Ser Val Gly Asn Ser Gln Gln Leu Arg Pro
     160                 165                 170

 aat tta acc cat agt atg gca agc atg cca cca cag aga aca tca aac      638
 Asn Leu Thr His Ser Met Ala Ser Met Pro Pro Gln Arg Thr Ser Asn
 175                 180                 185                 190

 gta atg atc aca tcc aac aca act gca cca aac tgg gcc tct caa gaa      686
 Val Met Ile Thr Ser Asn Thr Thr Ala Pro Asn Trp Ala Ser Gln Glu
                 195                 200                 205

 gga aca agc aaa cag caa gaa gcc ctg acg tct gca gga gtc cgc ttc      734
 Gly Thr Ser Lys Gln Gln Glu Ala Leu Thr Ser Ala Gly Val Arg Phe
             210                 215                 220

 ccc aca ggt aca cct gca gcc tat acc cca aat cag tca ctg caa cag      782
 Pro Thr Gly Thr Pro Ala Ala Tyr Thr Pro Asn Gln Ser Leu Gln Gln
         225                 230                 235

 gca gta ggt agc cag caa ttt tcc cag agg gca gtg gct cct cct aac      830
 Ala Val Gly Ser Gln Gln Phe Ser Gln Arg Ala Val Ala Pro Pro Asn
     240                 245                 250

 cag tta aca cca gca gtg caa atg aga ccc atg aac caa atg agc caa      878
 Gln Leu Thr Pro Ala Val Gln Met Arg Pro Met Asn Gln Met Ser Gln
 255                 260                 265                 270

 aca cta aat ggg caa acc atg ggt ccc ctc agg ggt ctg aat ctc aga      926
 Thr Leu Asn Gly Gln Thr Met Gly Pro Leu Arg Gly Leu Asn Leu Arg
                 275                 280                 285

 ccc aat cag cta agc aca cag att ttg cct aat ttg aat cag tca gga      974
 Pro Asn Gln Leu Ser Thr Gln Ile Leu Pro Asn Leu Asn Gln Ser Gly
             290                 295                 300

 aca ggg ttg aat cag tcg agg acg ggc atc aac cag cca cca tcc ctg     1022
 Thr Gly Leu Asn Gln Ser Arg Thr Gly Ile Asn Gln Pro Pro Ser Leu
         305                 310                 315

 acg ccc agc aat ttt cct tca ccc aac caa agt tcc agg gct ttt caa     1070
 Thr Pro Ser Asn Phe Pro Ser Pro Asn Gln Ser Ser Arg Ala Phe Gln
     320                 325                 330

 gga act gac cac agc agt gac tta gct ttt gac ttc ctc agc caa caa     1118
 Gly Thr Asp His Ser Ser Asp Leu Ala Phe Asp Phe Leu Ser Gln Gln
 335                 340                 345                 350

 aat gat aac atg ggc cct gcc cta aac agt gat gct gat ttc att gat     1166
 Asn Asp Asn Met Gly Pro Ala Leu Asn Ser Asp Ala Asp Phe Ile Asp
                 355                 360                 365

 tct tta ttg aag aca gag cct ggt aat gat gac tgg atg aaa gac atc     1214
 Ser Leu Leu Lys Thr Glu Pro Gly Asn Asp Asp Trp Met Lys Asp Ile
             370                 375                 380

 aat ctt gat gaa atc ttg ggg aac aat tcc taa agaagaaa gggaagacaa     1265
 Asn Leu Asp Glu Ile Leu Gly Asn Asn Ser 
         385                 390

 tttacaaact ccatagcact aaaaggcagt atattacaga aactctgtag aggctgaact   1325

 gttgatgttc aggtggacta ctgaagatta catgctaaaa atggaagcac aa           1377




      <210> 116
      <211> 1095
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(890)

      <400> 116
 gggtagtgga gggattttgt ccccagcagt ggcctctgag agtctttcag   atg gac      56
                                                          Met Asp
                                                            1

 aca ggt ccg ctg aac gcg gcc agc ctg agg gag gag cag ctc cac ctg      104
 Thr Gly Pro Leu Asn Ala Ala Ser Leu Arg Glu Glu Gln Leu His Leu
           5                  10                  15

 tcc ttg ctg gtg tcc agc ggc tgg aga aca atc agc ttc cac gtg gtg      152
 Ser Leu Leu Val Ser Ser Gly Trp Arg Thr Ile Ser Phe His Val Val
      20                  25                  30

 ccc gtg gtg aga agg aag ctt ggg gcg cct gcc ctg gag ggg gtg cag      200
 Pro Val Val Arg Arg Lys Leu Gly Ala Pro Ala Leu Glu Gly Val Gln
  35                  40                  45                  50

 cag atg ccc gga ttc cct gag ggc agc ttg aga aga atc ctc agc caa      248
 Gln Met Pro Gly Phe Pro Glu Gly Ser Leu Arg Arg Ile Leu Ser Gln
                  55                  60                  65

 ggg gtg gac ctg gtg ccg gcc agt gcc cag ctc tgg agg acc tcc act      296
 Gly Val Asp Leu Val Pro Ala Ser Ala Gln Leu Trp Arg Thr Ser Thr
              70                  75                  80

 gac tac ctg ctc acg agg ctg ctg ggg gag ctg ggc tcc ctg cag ggt      344
 Asp Tyr Leu Leu Thr Arg Leu Leu Gly Glu Leu Gly Ser Leu Gln Gly
          85                  90                  95

 cat cgc ctg gac agc ctc tcc atc ctc gac cgg gtc aac cac gag agc      392
 His Arg Leu Asp Ser Leu Ser Ile Leu Asp Arg Val Asn His Glu Ser
     100                 105                 110

 tgg cgt gac agt ggc cag act gac ggc ctg acc ttt ggc cac ctg aag      440
 Trp Arg Asp Ser Gly Gln Thr Asp Gly Leu Thr Phe Gly His Leu Lys
 115                 120                 125                 130

 atg gtg ctg ctg tgg gcc tct gtg ctc ttc ccg gcg ccc gag gac tgg      488
 Met Val Leu Leu Trp Ala Ser Val Leu Phe Pro Ala Pro Glu Asp Trp
                 135                 140                 145

 gca gag ccg cag ggc gcc gtg tac cgc ctg ctg gtg gtg ctg ctc tgt      536
 Ala Glu Pro Gln Gly Ala Val Tyr Arg Leu Leu Val Val Leu Leu Cys
             150                 155                 160

 tgc ctg gcc acg cgg aag ctg ccc cac ttc ctc cac ccg cag cgc aac      584
 Cys Leu Ala Thr Arg Lys Leu Pro His Phe Leu His Pro Gln Arg Asn
         165                 170                 175

 ctg ctg cag ggc agc ggc ctg gac ctt ggt gcc atc tac cag cgc gtg      632
 Leu Leu Gln Gly Ser Gly Leu Asp Leu Gly Ala Ile Tyr Gln Arg Val
     180                 185                 190

 gag ggc ttc gcc agc cag ccc gag gcg gcc ctg cgc atc cac gcc acc      680
 Glu Gly Phe Ala Ser Gln Pro Glu Ala Ala Leu Arg Ile His Ala Thr
 195                 200                 205                 210

 cac ctg ggc cgc agc ccc ccg ccg cgc atc ggc tcc ggg ctc aag gcg      728
 His Leu Gly Arg Ser Pro Pro Pro Arg Ile Gly Ser Gly Leu Lys Ala
                 215                 220                 225

 ctc ctg cag ctg cca gcc agt gac ccc act tac tgg gcc act gcc tac      776
 Leu Leu Gln Leu Pro Ala Ser Asp Pro Thr Tyr Trp Ala Thr Ala Tyr
             230                 235                 240

 ttc gac gtc ctg ctg gac aag ttc cag gtc ttc aac atc cag gat aag      824
 Phe Asp Val Leu Leu Asp Lys Phe Gln Val Phe Asn Ile Gln Asp Lys
         245                 250                 255

 gac cgg atc tct gcc atg cag agc atc ttc cag aag acc agg act ctg      872
 Asp Arg Ile Ser Ala Met Gln Ser Ile Phe Gln Lys Thr Arg Thr Leu
     260                 265                 270

 gga ggc gag gag agc tga gctggg ccacctggtc tcagccacct gttcttggct      926
 Gly Gly Glu Glu Ser 
 275

 ccccaacaga ctctgcactg caccatggga ggctcctggg atgtttggaa gaagaaacgg    986

 gcttctcctt gagggggtag tggagggatt ttgtccccag cagtggcctc tgagagtctt   1046

 tcagtgcctg gtggggcagg gcaagcctct tggagcacct cctccctgg               1095




      <210> 117
      <211> 2567
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1126)..(1701)

      <220>
      <221> misc_feature
      <222> (1)...(2567)
      <223> n = a,t,c or g

      <400> 117
 ggccgcgctc ggcgccccgg ccgggccact gggccacagg ccacgcggcc acgcagtccg     60

 agcgggagcc gagccgggcg gggcgagggc agctccggga agtaacgtcc cagggatgga    120

 agtgcttgga tgcggtgctg ctggctgcgg atgtgcgcaa ggagatggga tggagagcct    180

 gagttggcat tcgtataaat gacctgcctg gctcccacca tgagtgctga gcttaacgtg    240

 cctatcgacc cctctgctcc tgcctgccct gagcccggcc ataagggcat ggattaccgg    300

 gactgggtcc gccgcagcta cctggaactg gtcacctcta accaccactc ggtacaggcc    360

 ctgtcgtggc ggaagctcta cctgagcagg gccaagctga aggcctccag caggacctcc    420

 gccctcctct ccggctttgc catggtggcc atggtggagg tgcagctgga gacgcagtac    480

 cagtacccgc ggccgctgct gattgccttc agcgcctgca ccacggtgct ggtggccgtg    540

 cacctgttcg ccctcctcat cagcacctgc atcctgccca atgtggaggc cgtgagcaac    600

 atccacaacc tgaactccat cagcgagtcc ccgcatgagc gcatgcaccc ctacatcgag    660

 ctggcctggg gcttctccac cgtgcttggc atcctactct tcctggccga ggtggtgctg    720

 ctctgctgga tcaagttcct ccccgtggat gcccggcgcc agcctggccc cccacctggc    780

 cctgggagtc acacgggctg gcaggccgcc ctggtgtcca ccatcatcat ggtgcccgtg    840

 ggcctcatct tcgtggtctt caccatccac ttctaccgct ccctggtgcg ccacaaaacg    900

 gagcgccaca accgcgagat cgaggagctc cacaagctca aggtccagct ggacgggcat    960

 gagcgcagcc tgcaggtctt gtgaggggcc gagggccggg gctgggagcg gccctgtgcc   1020

 cgggagtccg cagaggcggg gatttgtcag atgcagacat tttgcaaggc tgccgggtag   1080

 ttcaagacca aagttttcct cttgtcttaa taccataagg actgg    atg act tct    1134
                                                      Met Thr Ser
                                                        1

 cct gag ata gaa ccg ttt ggt tca atg agg gac tgt gtt gct aag agc     1182
 Pro Glu Ile Glu Pro Phe Gly Ser Met Arg Asp Cys Val Ala Lys Ser
       5                  10                  15

 gtt ggg ggc aaa gcc agg ctg gtt cct tgg cct cgg ggt ttc ctg ggt     1230
 Val Gly Gly Lys Ala Arg Leu Val Pro Trp Pro Arg Gly Phe Leu Gly
  20                  25                  30                  35

 cgg gga cac ggt gaa gag gct cca gcg gga cct gcc cat cag tcc tgg     1278
 Arg Gly His Gly Glu Glu Ala Pro Ala Gly Pro Ala His Gln Ser Trp
                  40                  45                  50

 gcc agg agg ggc tcc aag cag cac cca gcg gtc cgg ggg agt ctc aga     1326
 Ala Arg Arg Gly Ser Lys Gln His Pro Ala Val Arg Gly Ser Leu Arg
              55                  60                  65

 ccc ggc atg cgt ggc tgg cag acc tgg gag agc cag ggc agg gtt ttg     1374
 Pro Gly Met Arg Gly Trp Gln Thr Trp Glu Ser Gln Gly Arg Val Leu
          70                  75                  80

 cgt tca gag aag gat tgc ccc aga gac ccg tgg tgg act tca tgg gtg     1422
 Arg Ser Glu Lys Asp Cys Pro Arg Asp Pro Trp Trp Thr Ser Trp Val
      85                  90                  95

 ctg agt ggc ccg tgt gac agt gat gac acg aag gct tcg gcg ttt gag     1470
 Leu Ser Gly Pro Cys Asp Ser Asp Asp Thr Lys Ala Ser Ala Phe Glu
 100                 105                 110                 115

 tgg gtg cag gtg cac gcc agg gct tgg tgc ttc cct gcc tgg ccc tgg     1518
 Trp Val Gln Val His Ala Arg Ala Trp Cys Phe Pro Ala Trp Pro Trp
                 120                 125                 130

 agg gag ctg ggt ggc ctg gct tca ggg gaa gac agg agc cag gac aca     1566
 Arg Glu Leu Gly Gly Leu Ala Ser Gly Glu Asp Arg Ser Gln Asp Thr
             135                 140                 145

 cgt cag ccc agc agg tgt ggg ggg tgc tgc agc cct cgg cag tgg ggt     1614
 Arg Gln Pro Ser Arg Cys Gly Gly Cys Cys Ser Pro Arg Gln Trp Gly
         150                 155                 160

 cag gcc ctg ggg gat gtt tcc aat ggt ggg cag cct ggc cag gcc gga     1662
 Gln Ala Leu Gly Asp Val Ser Asn Gly Gly Gln Pro Gly Gln Ala Gly
     165                 170                 175

 gaa gac atg ttc acg ggc atc tat cag atg ccc cct tga ggaggctgag      1711
 Glu Asp Met Phe Thr Gly Ile Tyr Gln Met Pro Pro 
 180                 185                 190

 ttatttgagg gctgctgcaa agtacgctag gctcaaattc tcttttccca gccagagccc   1771

 tggccacacg gactcagagg ggccaccggg gtggggaaag gacccctccc cgaccccccg   1831

 cagccactgg cctccagctc tcggccacag aatggcctct aaggctgact cagccgctcc   1891

 cttgggctgt ggcagcagga ggcgggggct ctggctcagg ccccggagcc tgtgcagctt   1951

 gcccatggcc ctaggcagcg aggggacagc ctgggggact tcctgcctag gcaaggtcat   2011

 tggccgggcc tggcctgtgg atagtggggc caggggccgg cccaggccaa atgagtgccc   2071

 tccttgttat gacaccaagt gactacaagg gaggcaagac ccctccaggc ctctcagccg   2131

 acactgggtc ccaccacaca cagtgactgt gccgtgcagt gcaggttctg gccttttcct   2191

 tgaaggcatc tggtagaccc gaagccacgc tctcgggccg cacatgcacg ccgcagcacc   2251

 agctgccctg agctgcttgt acaaccaaac acctttcccc tcttctccag ctgtaacctg   2311

 gagagtcagc catgccttgt cttttgttct cataaatagt cactgggcnc caggccctca   2371

 gtaggtttta aggagtcccc agccctcctc ccttctgggc ccgaccagct tatactgctc   2431

 catcttcccc ggccacatgc cccgccaagt actgcacagg gaccccccac ccaggggccc   2491

 tgctccgtga gataatgtga aatacgactg tggaccaaac gcaataaaac ctctgtttgt   2551

 acgaagaaaa aaaaaa                                                   2567




      <210> 118
      <211> 1196
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(1127)

      <400> 118
 ctggacgagg ggcgccgtag tttgcgtttt cacctggtcg cccggcgcgc   atg gcg      56
                                                          Met Ala
                                                            1

 gcc gtt ctg aag ccg gtg ctg ctg ggc ctt cga gat gcg ccg gtg cac      104
 Ala Val Leu Lys Pro Val Leu Leu Gly Leu Arg Asp Ala Pro Val His
           5                  10                  15

 ggc agc ccc aca ggg ccg ggt gcc tgg act gct agc aag ctg ggc ggc      152
 Gly Ser Pro Thr Gly Pro Gly Ala Trp Thr Ala Ser Lys Leu Gly Gly
      20                  25                  30

 att ccg gat gct ctg ccc acc gtg gct gcg ccc agg ccc gtg tgt cag      200
 Ile Pro Asp Ala Leu Pro Thr Val Ala Ala Pro Arg Pro Val Cys Gln
  35                  40                  45                  50

 cgc tgc ggg cag ccg ctc gct ctg gtc gtg cag gtg tat tgc ccg ctg      248
 Arg Cys Gly Gln Pro Leu Ala Leu Val Val Gln Val Tyr Cys Pro Leu
                  55                  60                  65

 gaa ggc tcc ccg ttt cac cgt ctg ctg cac gtg ttc gcg tgc gcc tgc      296
 Glu Gly Ser Pro Phe His Arg Leu Leu His Val Phe Ala Cys Ala Cys
              70                  75                  80

 ccc ggc tgt agc acc ggc ggt gcg cgc agc tgg aag gtg ttc cgc tcc      344
 Pro Gly Cys Ser Thr Gly Gly Ala Arg Ser Trp Lys Val Phe Arg Ser
          85                  90                  95

 cag tgc ctg cag gtg cca gag aga gag gcg cag gac gct cag aaa cag      392
 Gln Cys Leu Gln Val Pro Glu Arg Glu Ala Gln Asp Ala Gln Lys Gln
     100                 105                 110

 gga aac agc ctt gca gct gag gac tgg tgt gaa ggt gct gat gac tgg      440
 Gly Asn Ser Leu Ala Ala Glu Asp Trp Cys Glu Gly Ala Asp Asp Trp
 115                 120                 125                 130

 gga agt gat act gag gag ggg cct tca cca cag ttt acc ttg gat ttt      488
 Gly Ser Asp Thr Glu Glu Gly Pro Ser Pro Gln Phe Thr Leu Asp Phe
                 135                 140                 145

 ggg aat gat gcc agc agt gcc aaa gac gta gac tgg act gct cgg ctc      536
 Gly Asn Asp Ala Ser Ser Ala Lys Asp Val Asp Trp Thr Ala Arg Leu
             150                 155                 160

 caa gac ctc cgc ctg cag gat gct gtc ctg ggt gct gcc cat cct gtg      584
 Gln Asp Leu Arg Leu Gln Asp Ala Val Leu Gly Ala Ala His Pro Val
         165                 170                 175

 cct cct ggg ctg ccg ctc ttc ctg ccc tac tac atc tgt gtt gca gat      632
 Pro Pro Gly Leu Pro Leu Phe Leu Pro Tyr Tyr Ile Cys Val Ala Asp
     180                 185                 190

 gag gat gat tac agg gac ttt gtc aac ctg gat cat gcc cac agc ctt      680
 Glu Asp Asp Tyr Arg Asp Phe Val Asn Leu Asp His Ala His Ser Leu
 195                 200                 205                 210

 ctg agg gac tat cag cag aga gaa ggc att gcc atg gat cag ttg ctt      728
 Leu Arg Asp Tyr Gln Gln Arg Glu Gly Ile Ala Met Asp Gln Leu Leu
                 215                 220                 225

 tcc caa agc ctt cct aat gat ggt gat gaa aaa tat gag aag acc ata      776
 Ser Gln Ser Leu Pro Asn Asp Gly Asp Glu Lys Tyr Glu Lys Thr Ile
             230                 235                 240

 att aaa agt gga gat cag acg ttt tac aaa ttc atg aag cga att gct      824
 Ile Lys Ser Gly Asp Gln Thr Phe Tyr Lys Phe Met Lys Arg Ile Ala
         245                 250                 255

 gct tgt cag gag cag att ttg agg tat tcc tgg agt gga gag cca ctc      872
 Ala Cys Gln Glu Gln Ile Leu Arg Tyr Ser Trp Ser Gly Glu Pro Leu
     260                 265                 270

 ttt ttg acc tgc cct aca tca gaa gtc acc gag ctc cca gcc tgc agc      920
 Phe Leu Thr Cys Pro Thr Ser Glu Val Thr Glu Leu Pro Ala Cys Ser
 275                 280                 285                 290

 cag tgt gga ggc caa agg ata ttt gag ttt cag ctt atg cca gca ctg      968
 Gln Cys Gly Gly Gln Arg Ile Phe Glu Phe Gln Leu Met Pro Ala Leu
                 295                 300                 305

 gtc agc atg ctc aag agt gct aat tta ggt ctt tct gtg gaa ttt gga     1016
 Val Ser Met Leu Lys Ser Ala Asn Leu Gly Leu Ser Val Glu Phe Gly
             310                 315                 320

 aca att cta gtt tac aca tgt gag aag agt tgc tgg ccc cca aat cat     1064
 Thr Ile Leu Val Tyr Thr Cys Glu Lys Ser Cys Trp Pro Pro Asn His
         325                 330                 335

 cag act ccc atg gaa gaa ttt tgt att ata caa gaa gac cca gat gaa     1112
 Gln Thr Pro Met Glu Glu Phe Cys Ile Ile Gln Glu Asp Pro Asp Glu
     340                 345                 350

 tta ttg ttt aag tag agcatttgtt ttaatttata ttaataaaag gaaatgctct     1167
 Leu Leu Phe Lys 
 355

 gtcgagcggc cgcgaattta gtagtagta                                     1196




      <210> 119
      <211> 1201
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (196)..(1083)

      <400> 119
 gaggactaat aacgatacag tcagccaaac tataatgata gatctagaat taggtgcaat     60

 caaggcttat aagagtgaat ttcaagtagt taccagtaaa gtttgtcttt ttcattcagc    120

 ctgatgcctt taacagaaaa ctcagatgag tggataggtc acgtgagatg gcagtgacaa    180

 aaacttcagt ttaaa atg cct tat gga tct gta ttg gca ttc ctt ccc gct     231
                  Met Pro Tyr Gly Ser Val Leu Ala Phe Leu Pro Ala
                    1               5                  10

 gat gaa atg cta gga gct ttt aat gaa tta aag ctg cat ttg cat gaa      279
 Asp Glu Met Leu Gly Ala Phe Asn Glu Leu Lys Leu His Leu His Glu
          15                  20                  25

 gaa gcc aga gaa att act gac tgg ttt gaa gat aat gac gtg cat ggt      327
 Glu Ala Arg Glu Ile Thr Asp Trp Phe Glu Asp Asn Asp Val His Gly
      30                  35                  40

 cgg ata aga aga cat gcc ctg gag ttg ctg ttt gac cat cag tat tgt      375
 Arg Ile Arg Arg His Ala Leu Glu Leu Leu Phe Asp His Gln Tyr Cys
  45                  50                  55                  60

 ttc cac caa att tgt gat ctg cat ata agt act gct cac atg ata gag      423
 Phe His Gln Ile Cys Asp Leu His Ile Ser Thr Ala His Met Ile Glu
                  65                  70                  75

 gct gat gtc ctt ctt cca agt gat gga tca gaa cac agc cag cca att      471
 Ala Asp Val Leu Leu Pro Ser Asp Gly Ser Glu His Ser Gln Pro Ile
              80                  85                  90

 atg gcc cat ccc cct gaa aca aac agt gat aat act cta cag gag tgg      519
 Met Ala His Pro Pro Glu Thr Asn Ser Asp Asn Thr Leu Gln Glu Trp
          95                 100                 105

 ctg act gaa gtt atg aaa agc aat aaa ggc atc aag ctg gat ttc aaa      567
 Leu Thr Glu Val Met Lys Ser Asn Lys Gly Ile Lys Leu Asp Phe Lys
     110                 115                 120

 agt ctg gca gtt gta gaa cca tcc atg atg ctc ttg gaa aat gtg aag      615
 Ser Leu Ala Val Val Glu Pro Ser Met Met Leu Leu Glu Asn Val Lys
 125                 130                 135                 140

 agg cat ctg aag cgt cct gta tgg att aat gcc gat att ctt cct ggt      663
 Arg His Leu Lys Arg Pro Val Trp Ile Asn Ala Asp Ile Leu Pro Gly
                 145                 150                 155

 cca aat gga aat agc aaa gta ata gat gca aaa cca ttt tta gac acc      711
 Pro Asn Gly Asn Ser Lys Val Ile Asp Ala Lys Pro Phe Leu Asp Thr
             160                 165                 170

 gtg ata tcc ttc ttt cca gac gtg acg ttt tcc ctg ggt tgg aca aca      759
 Val Ile Ser Phe Phe Pro Asp Val Thr Phe Ser Leu Gly Trp Thr Thr
         175                 180                 185

 gga tgg cat cct gag aaa gtc aat gaa ggg tac agt tgg aca atg gtg      807
 Gly Trp His Pro Glu Lys Val Asn Glu Gly Tyr Ser Trp Thr Met Val
     190                 195                 200

 aaa gag atg gaa tat ata tgt aat gaa cta agt cag cct gta acg ttc      855
 Lys Glu Met Glu Tyr Ile Cys Asn Glu Leu Ser Gln Pro Val Thr Phe
 205                 210                 215                 220

 cct gtc aga gca gca tta gtc agg cag tct tgt tct cag tta ctt tgg      903
 Pro Val Arg Ala Ala Leu Val Arg Gln Ser Cys Ser Gln Leu Leu Trp
                 225                 230                 235

 ctg tta aag aaa tca aac agg tac agc ctg act att tgg act gga aaa      951
 Leu Leu Lys Lys Ser Asn Arg Tyr Ser Leu Thr Ile Trp Thr Gly Lys
             240                 245                 250

 aat gat aac tat tcc gtt gaa gat tta ctt tac att aga gac cat ttt      999
 Asn Asp Asn Tyr Ser Val Glu Asp Leu Leu Tyr Ile Arg Asp His Phe
         255                 260                 265

 gac aaa aaa caa gtt ttc tat gac atc ttg gaa cca caa aac cat gaa     1047
 Asp Lys Lys Gln Val Phe Tyr Asp Ile Leu Glu Pro Gln Asn His Glu
     270                 275                 280

 ttt aaa caa gcc att gga atc aaa gtt aat ctc taa gaag aagattctca     1097
 Phe Lys Gln Ala Ile Gly Ile Lys Val Asn Leu 
 285                 290                 295

 attatttcct gtgttttggt ttcataatcc ttctctccat tggtctgaat taattaccat   1157

 ataaattatg gttattgatt gacgttccaa gtcatctaat caaa                    1201




      <210> 120
      <211> 1976
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (113)..(883)

      <400> 120
 cctggtggcg aattcggcac gagggtcgga ggcgcgtgga gagccagggt ccgggcctga     60

 ggctggcgcc cgattcttct gcactgcggg tcgcggcctg gagccgttcg ta    atg     115
                                                              Met
                                                                1

 cga gag gtg cgg gcg cgg ctg gcg gcc acg cag gtt gaa tat att tca      163
 Arg Glu Val Arg Ala Arg Leu Ala Ala Thr Gln Val Glu Tyr Ile Ser
               5                  10                  15

 gga aag gtt ttt ttc acc acc tgt tct gat ttg aat atg ttg aag aaa      211
 Gly Lys Val Phe Phe Thr Thr Cys Ser Asp Leu Asn Met Leu Lys Lys
          20                  25                  30

 tta aaa tct gca gaa aga tta ttt ttg ctg att aaa aag cag ttt cca      259
 Leu Lys Ser Ala Glu Arg Leu Phe Leu Leu Ile Lys Lys Gln Phe Pro
      35                  40                  45

 ctt att att tct tct gta agt aaa gga aaa ata ttt aat gaa atg caa      307
 Leu Ile Ile Ser Ser Val Ser Lys Gly Lys Ile Phe Asn Glu Met Gln
  50                  55                  60                  65

 aga ctt ata aat gaa gat cca gga agt tgg ttg aat gcc att tca att      355
 Arg Leu Ile Asn Glu Asp Pro Gly Ser Trp Leu Asn Ala Ile Ser Ile
                  70                  75                  80

 tgg aaa aat ctt ctt gaa ctt gat gca aaa aag gaa aaa ctt tct cag      403
 Trp Lys Asn Leu Leu Glu Leu Asp Ala Lys Lys Glu Lys Leu Ser Gln
              85                  90                  95

 aga gat gat aac caa cta aaa aga aaa gtg gga gaa aat gaa atc att      451
 Arg Asp Asp Asn Gln Leu Lys Arg Lys Val Gly Glu Asn Glu Ile Ile
         100                 105                 110

 gca aag aaa tta aaa ata gaa caa atg caa aag ata gaa gag aat agg      499
 Ala Lys Lys Leu Lys Ile Glu Gln Met Gln Lys Ile Glu Glu Asn Arg
     115                 120                 125

 gac tgc cag ctg gaa aaa caa ata aaa gaa gaa act ctg gag caa aga      547
 Asp Cys Gln Leu Glu Lys Gln Ile Lys Glu Glu Thr Leu Glu Gln Arg
 130                 135                 140                 145

 gat ttt acc act aaa agc gaa aag ttt caa gaa gaa gaa ttt cag aat      595
 Asp Phe Thr Thr Lys Ser Glu Lys Phe Gln Glu Glu Glu Phe Gln Asn
                 150                 155                 160

 gac ata gag aaa gca att gat act cat aat cag aat gac ttg act ttc      643
 Asp Ile Glu Lys Ala Ile Asp Thr His Asn Gln Asn Asp Leu Thr Phe
             165                 170                 175

 aga gta tct tgt cgc tgc agt gga act att gga aag gcc ttc act gca      691
 Arg Val Ser Cys Arg Cys Ser Gly Thr Ile Gly Lys Ala Phe Thr Ala
         180                 185                 190

 cag gag gta gga caa cgt aat tgg aat gct tat tat gaa aca ctt tgg      739
 Gln Glu Val Gly Gln Arg Asn Trp Asn Ala Tyr Tyr Glu Thr Leu Trp
     195                 200                 205

 atg gaa cgc aga ctt gag gaa ttc cac caa tta aga gat ctt att act      787
 Met Glu Arg Arg Leu Glu Glu Phe His Gln Leu Arg Asp Leu Ile Thr
 210                 215                 220                 225

 cta aat gac att tac tct gtg gtg ggg att cct gtg ttc agg gtt tcc      835
 Leu Asn Asp Ile Tyr Ser Val Val Gly Ile Pro Val Phe Arg Val Ser
                 230                 235                 240

 cta gcc agc aga gtt aca tca aga cag ctg gac tgc gat cta caa tag      883
 Leu Ala Ser Arg Val Thr Ser Arg Gln Leu Asp Cys Asp Leu Gln 
             245                 250                 255

 cgtgggcaat ggcatctctg gctgacatta aggctggtgc atttgtttta gatccaatgt    943

 gtggacttgg aacaatactt ttggaagctg ctaaagaatg gccagatgtg tattatgtag   1003

 gtgctgatgt cagcgactca cagttactag gtacttggga caatctgaaa gctgcaggcc   1063

 ttgaggataa aattgaatta cttaaaatct ctgttataga attgccattg ccttcagaaa   1123

 gggttgatat tattatttct gacattccat ttgggaaaaa gtttaagtta ggaaaagaca   1183

 tcaaaagcat tctacaagaa atggaaagag tgcttcatgt tggcggaacc attgtattgt   1243

 tgcttagtga agatcaccac aggcgcctta cagattgtaa agagagcaac atccctttca   1303

 attccaagga cagtcacaca gatgaacctg gaattaaaaa gtgcttgaat cctgaagaaa   1363

 aaactggtgc attcaagaca gcgtcaactt cattcgaagc cagtaaccac aaattcttag   1423

 acagaatgtc accatttggc tccttggtac cagtggaatg ctacaaagtt agccttggaa   1483

 agacagatgc gttcatatgt aaatataaga agtcgcactc ttctggactg tagcaggctt   1543

 gctgccatca gccgggttca ggcccttgta agttagctgt acagcagaag tttgctgtct   1603

 ctaggattca tatagcaccc acagagctcc aagtaaccaa attcccccaa agacaggagg   1663

 tgtggctgat gggtacacat gcttggtaag agtttctgct ttatattcta aagtacttaa   1723

 tgtttttgag aaaaaagtta ccgaatattt tttagactta agttttatct tctgtcagaa   1783

 tgtgaaaagt tctgcccagt ttctgagcaa aaacttcaat ttcaaaataa aggttttcag   1843

 gggttcactt aagtgtatca caatcaacac cagacgggat attttaacta tcagattttc   1903

 ggaaatgtaa aaacctttat gtgtaacttc ttttgatatt aaacttgatt tttgagcctg   1963

 taaaaaaaaa aaa                                                      1976




      <210> 121
      <211> 595
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (300)..(548)

      <400> 121
 tgggcctttg gtttgggttt taacccattt tcttgttttg gaaaagagga aggggggccc     60

 attttgagtt tcccaagggt gggtttggag gggcccctgg ttttccagcc tggaccccca    120

 ggtttggcca accccaggcc ttgccccagg ccaagtccaa atgtttacag ggagccttct    180

 ggccagtccc ccaaccccag ccgtttggag gccccaaagg aaaaagccca aaaagggtta    240

 aatacccccc ttcctggaaa ccccagtccc cctgctcatt ctcgtagctt tttaaaaaa     299                                                                 
 atg aaa gta aag gaa aaa aaa aaa act gca aat cta gaa aac ttt tta      347
 Met Lys Val Lys Glu Lys Lys Lys Thr Ala Asn Leu Glu Asn Phe Leu
   1               5                  10                  15

 gag aaa aac tat tta aaa ctg tca gat cct gac cag caa gcc ccc ccc      395
 Glu Lys Asn Tyr Leu Lys Leu Ser Asp Pro Asp Gln Gln Ala Pro Pro
              20                  25                  30

 cag ccc ccc ttc caa gtg act ccg tgc ctt gag tgt gtc tgc gtg ttt      443
 Gln Pro Pro Phe Gln Val Thr Pro Cys Leu Glu Cys Val Cys Val Phe
          35                  40                  45

 aca ccc gtc cct ctg ctg gcc gcc ccc gtg cga gcg gca ccc ctg ccc      491
 Thr Pro Val Pro Leu Leu Ala Ala Pro Val Arg Ala Ala Pro Leu Pro
      50                  55                  60

 tgc cct cca cag aat tgg gtt cca agg gct gtt cca gac aac tgc caa      539
 Cys Pro Pro Gln Asn Trp Val Pro Arg Ala Val Pro Asp Asn Cys Gln
  65                  70                  75                  80

 cgt cac tga gggccct gccccagcgg ccctggcccc aggctctatt aacctaaaat      595
 Arg His 






      <210> 122
      <211> 969
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (460)..(585)

      <400> 122
 cctttaatct tgaacatttc cacaactttt atgacattta atttcctctt ttatgccatt     60

 gagacttttg aagaatgcag tcactcctcc cacctttcat taaatagaat tttccttatc    120

 tttggtacat gtggtatttc ctcataatta gattcaagct gtacgttctg cccataatat    180

 cacatacacg atgggtcctt ctcaaggcat tctatctaga aatacgtctt gtctctctgc    240

 ccccctattc gtgatgctaa ttttgattat ttggtcaaga tattttctga tattatcact    300

 ctgcagttaa ttttatatag ttactatttt ttccccacgc aattaataag caagtgctgg    360

 agagacattt taagattctg taaatatcct gctgcacatg aaaagtttcc ccctagattg    420

 agcgtctgct gatgattctt gtgtgatcca gcatttact   atg ttg gtt gta aaa     474
                                              Met Leu Val Val Lys
                                                1               5

 caa tgc ttt tct gac tcc agt att ctc tcc aca ttc gta agt tgg ctc      522
 Gln Cys Phe Ser Asp Ser Ser Ile Leu Ser Thr Phe Val Ser Trp Leu
                  10                  15                  20

 tca gca ttc tac tgt aaa gaa gga ccc tcc ttt ctc ccc agg aag gtg      570
 Ser Ala Phe Tyr Cys Lys Glu Gly Pro Ser Phe Leu Pro Arg Lys Val
              25                  30                  35

 ttt ttg ttt ttt taa atgaaggaga ccgtggaaac tcgccagatg acctgtagct      625
 Phe Leu Phe Phe 
          40

 cctggagctt ggcaaaggct gggcaaacgc ccacctgaag actatgcagg caatcaggac    685

 atgacacaga gccgggagag gcctgctctt cggctctgcc ctgaacctca ttcggcaggt    745

 ggaggtattt aggcatttga gggaatctca gctttgggag gccactttgt aagtgatctt    805

 aagagattaa gtacatcctt aattaaaaga aatggtaaca cctccgcctg cttgctgtga    865

 gtttattcat ttgaattccc catctccccc aatgggaaat aacacagaat tgcaattatt    925

 tataaaatct taaattggct tcttttctct aggaaaatag ccct                     969




      <210> 123
      <211> 775
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (236)..(724)

      <400> 123
 acttcccggg tcgacgattt cgtgttacca cctaagaaat gaaacaactt tctgaaagcc     60

 cgggaaggag atgctctcct gagctcctca tgctccacaa ggaggtcaaa atcaccaccc    120

 tctttcagcc actattttaa gtttgaaata aacagcaagc ttcctgccac cttgagtctt    180

 cctttgatgt gcactccctg caagcagttt caggcggcag cagaacactc aagag atg     238
                                                              Met
                                                                1

 cct tgg aat gtg aga atg caa agc ccc aaa cag aga aca tcc aga tgc      286
 Pro Trp Asn Val Arg Met Gln Ser Pro Lys Gln Arg Thr Ser Arg Cys
               5                  10                  15

 tgg gat cac cat atc gct gaa ggg tgt ttc tgc ctt cca tgg aaa aaa      334
 Trp Asp His His Ile Ala Glu Gly Cys Phe Cys Leu Pro Trp Lys Lys
          20                  25                  30

 ata ctc att ttt gaa aag agg caa gat tcc caa aac gaa aat gaa aga      382
 Ile Leu Ile Phe Glu Lys Arg Gln Asp Ser Gln Asn Glu Asn Glu Arg
      35                  40                  45

 atg tca tct act ccc atc cag cag gac aat gtt gac cag acc tac tca      430
 Met Ser Ser Thr Pro Ile Gln Gln Asp Asn Val Asp Gln Thr Tyr Ser
  50                  55                  60                  65

 gag gag ctg tgc tat acc ctc atc aat cat cgg gtt ctc tgt aca agg      478
 Glu Glu Leu Cys Tyr Thr Leu Ile Asn His Arg Val Leu Cys Thr Arg
                  70                  75                  80

 cca tca ggg aac tct gct gaa gag tac tat gag aat gtt ccc tgc aaa      526
 Pro Ser Gly Asn Ser Ala Glu Glu Tyr Tyr Glu Asn Val Pro Cys Lys
              85                  90                  95

 gct gag aga ccc aga gag tcc ttg gga gga act gag act gag tat tca      574
 Ala Glu Arg Pro Arg Glu Ser Leu Gly Gly Thr Glu Thr Glu Tyr Ser
         100                 105                 110

 ctt cta cat atg cct tct aca gac ccc agg cat gcc cga tcc cca gaa      622
 Leu Leu His Met Pro Ser Thr Asp Pro Arg His Ala Arg Ser Pro Glu
     115                 120                 125

 gat gaa tat gaa ctt ctc atg cct cac aga atc tcc tct cac ttt ctg      670
 Asp Glu Tyr Glu Leu Leu Met Pro His Arg Ile Ser Ser His Phe Leu
 130                 135                 140                 145

 caa cag cca cgt cca ctt atg gcc cct tct gag act cag ttt tcc cat      718
 Gln Gln Pro Arg Pro Leu Met Ala Pro Ser Glu Thr Gln Phe Ser His
                 150                 155                 160

 tta tag tgaagtggct ggactagcat ttgtttagca ccaacaaata aaaggtggga       774
 Leu 


 t                                                                    775




      <210> 124
      <211> 1899
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(1848)

      <400> 124
 agacacatgt gattgagaag gaagactaaa cttcacctgc aagcttccaa agatgcccaa     60

 cggcaactga caatggagct gcacgagtta caagacagga at   atg gag tgt cta     114
                                                  Met Glu Cys Leu
                                                    1

 gga atg tta cat gaa tcc caa gaa gaa ata aag gaa ctt cgt agt aga      162
 Gly Met Leu His Glu Ser Gln Glu Glu Ile Lys Glu Leu Arg Ser Arg
   5                  10                  15                  20

 tct ggc cct act gct cat ctc tac ttc tcc caa tca tat gga gct ttt      210
 Ser Gly Pro Thr Ala His Leu Tyr Phe Ser Gln Ser Tyr Gly Ala Phe
                  25                  30                  35

 act ggg gaa tct ttg gca gct gag att gag ggg act atg cgt aaa aag      258
 Thr Gly Glu Ser Leu Ala Ala Glu Ile Glu Gly Thr Met Arg Lys Lys
              40                  45                  50

 ctg agt ttg gat gag gaa tct tct ctc ttt aaa caa aaa gcc caa cag      306
 Leu Ser Leu Asp Glu Glu Ser Ser Leu Phe Lys Gln Lys Ala Gln Gln
          55                  60                  65

 aag cgg gta ttt gat acc gtc agg att gcc aat gac aca cgg ggc cgc      354
 Lys Arg Val Phe Asp Thr Val Arg Ile Ala Asn Asp Thr Arg Gly Arg
      70                  75                  80

 tct atc tca ttc cca gct ctg tta ccc att cca ggc tcc aac cgt tca      402
 Ser Ile Ser Phe Pro Ala Leu Leu Pro Ile Pro Gly Ser Asn Arg Ser
  85                  90                  95                 100

 agt gtc atc atg aca gca aaa cct ttt gag tct ggt ctt cag caa aca      450
 Ser Val Ile Met Thr Ala Lys Pro Phe Glu Ser Gly Leu Gln Gln Thr
                 105                 110                 115

 gag gac aaa tca ctc ctg aac cag ggg agc agc tca gag gag gtt gca      498
 Glu Asp Lys Ser Leu Leu Asn Gln Gly Ser Ser Ser Glu Glu Val Ala
             120                 125                 130

 ggg agc tcc cag aag atg ggc caa cca gga ccc tca gga gat agt gat      546
 Gly Ser Ser Gln Lys Met Gly Gln Pro Gly Pro Ser Gly Asp Ser Asp
         135                 140                 145

 ttg gct aca gca ctg cat cgc ctt agc ttg cgt cga caa aac tat tta      594
 Leu Ala Thr Ala Leu His Arg Leu Ser Leu Arg Arg Gln Asn Tyr Leu
     150                 155                 160

 agt gag aag cag ttc ttt gct gaa gaa tgg cag cgg aag atc cag gtt      642
 Ser Glu Lys Gln Phe Phe Ala Glu Glu Trp Gln Arg Lys Ile Gln Val
 165                 170                 175                 180

 ctg gca gac cag aag gaa gga gtt agt ggc tgt gtc acc ccg aca gag      690
 Leu Ala Asp Gln Lys Glu Gly Val Ser Gly Cys Val Thr Pro Thr Glu
                 185                 190                 195

 agc ctt gcc tct ctc tgc acc acc cag tca gag atc aca gac ctc agc      738
 Ser Leu Ala Ser Leu Cys Thr Thr Gln Ser Glu Ile Thr Asp Leu Ser
             200                 205                 210

 agt gcc agt tgc ctt cga ggt ttt atg cca gaa aaa tta caa att gtc      786
 Ser Ala Ser Cys Leu Arg Gly Phe Met Pro Glu Lys Leu Gln Ile Val
         215                 220                 225

 aag ccc ctt gaa gga tca caa act ctg tat cac tgg cag cag ctt gct      834
 Lys Pro Leu Glu Gly Ser Gln Thr Leu Tyr His Trp Gln Gln Leu Ala
     230                 235                 240

 caa cca aac ttg gga acc atc ctt gat cca cga cca ggt gtc att act      882
 Gln Pro Asn Leu Gly Thr Ile Leu Asp Pro Arg Pro Gly Val Ile Thr
 245                 250                 255                 260

 aaa ggc ttt acc cag ttg ccc ggg gat gct att tat cac atc tca gat      930
 Lys Gly Phe Thr Gln Leu Pro Gly Asp Ala Ile Tyr His Ile Ser Asp
                 265                 270                 275

 tta gaa gag gat gaa gag gag ggt att act ttt cag gtt cag caa cct      978
 Leu Glu Glu Asp Glu Glu Glu Gly Ile Thr Phe Gln Val Gln Gln Pro
             280                 285                 290

 ctt gaa gtg gaa gag aaa ctt tca aca tcc aag cca gta aca ggg atc     1026
 Leu Glu Val Glu Glu Lys Leu Ser Thr Ser Lys Pro Val Thr Gly Ile
         295                 300                 305

 ttc ctg cca ccc att act tca gca ggt gga cca gtt aca gtt gca acc     1074
 Phe Leu Pro Pro Ile Thr Ser Ala Gly Gly Pro Val Thr Val Ala Thr
     310                 315                 320

 gcc aac cca gga aag tgc ctg tcg tgc aca aac tca aca ttc act ttc     1122
 Ala Asn Pro Gly Lys Cys Leu Ser Cys Thr Asn Ser Thr Phe Thr Phe
 325                 330                 335                 340

 acc acc tgt aga ata tta cat ccc tct gac atc act cag gtt acc ccc     1170
 Thr Thr Cys Arg Ile Leu His Pro Ser Asp Ile Thr Gln Val Thr Pro
                 345                 350                 355

 agc tct ggg ttc cct tca tta tcc tgt gga agt agc ggt agc agt tca     1218
 Ser Ser Gly Phe Pro Ser Leu Ser Cys Gly Ser Ser Gly Ser Ser Ser
             360                 365                 370

 tcc aac acg gct gtg aat tct cct gcc ttg tcc tat aga ctc agc att     1266
 Ser Asn Thr Ala Val Asn Ser Pro Ala Leu Ser Tyr Arg Leu Ser Ile
         375                 380                 385

 ggt gag tcc atc acc aac cga cga gat tcc act aca acc ttc agt agc     1314
 Gly Glu Ser Ile Thr Asn Arg Arg Asp Ser Thr Thr Thr Phe Ser Ser
     390                 395                 400

 acc atg agc ttg gcc aaa ctt cta caa gag cga ggc atc tct gcc aaa     1362
 Thr Met Ser Leu Ala Lys Leu Leu Gln Glu Arg Gly Ile Ser Ala Lys
 405                 410                 415                 420

 gtg tac cac agc cca att tca gag aac ccc ctc cag cct ctc cct aaa     1410
 Val Tyr His Ser Pro Ile Ser Glu Asn Pro Leu Gln Pro Leu Pro Lys
                 425                 430                 435

 tcc ctg gct atc cct tcc aca cca cca aat tca cca tct cac tca cct     1458
 Ser Leu Ala Ile Pro Ser Thr Pro Pro Asn Ser Pro Ser His Ser Pro
             440                 445                 450

 tgc cct tct cct tta ccc ttt gag cct cga gtg cat ctc tct gaa aat     1506
 Cys Pro Ser Pro Leu Pro Phe Glu Pro Arg Val His Leu Ser Glu Asn
         455                 460                 465

 ttt ttg gcc tct cga cca gct gag aca ttc ctc cag gag atg tat ggc     1554
 Phe Leu Ala Ser Arg Pro Ala Glu Thr Phe Leu Gln Glu Met Tyr Gly
     470                 475                 480

 ttg aga ccc tcc cgg aac cct cct gat gtt ggc cag ttg aag atg aac     1602
 Leu Arg Pro Ser Arg Asn Pro Pro Asp Val Gly Gln Leu Lys Met Asn
 485                 490                 495                 500

 tta gtg gac agg ctg aag aga ctg ggg ata gcc aga gtg gtc aag aac     1650
 Leu Val Asp Arg Leu Lys Arg Leu Gly Ile Ala Arg Val Val Lys Asn
                 505                 510                 515

 cct ggt gcc caa gag aat gga aga tgc cag gag gca gaa aat ggt cct     1698
 Pro Gly Ala Gln Glu Asn Gly Arg Cys Gln Glu Ala Glu Asn Gly Pro
             520                 525                 530

 caa aaa cca gat tct gct gtt tat tta aat tca ggt agc agt tta tta     1746
 Gln Lys Pro Asp Ser Ala Val Tyr Leu Asn Ser Gly Ser Ser Leu Leu
         535                 540                 545

 ggt gga cta agg agg aat cag agt ctt cca gtc ata atg ggt agc ttt     1794
 Gly Gly Leu Arg Arg Asn Gln Ser Leu Pro Val Ile Met Gly Ser Phe
     550                 555                 560

 gct gcc cca gtt tgc aca tcc tca ccc aaa atg ggt gtc ctg aag gag     1842
 Ala Ala Pro Val Cys Thr Ser Ser Pro Lys Met Gly Val Leu Lys Glu
 565                 570                 575                 580

 gac tga ggttcagcag ttaactgacc ttttatacaa gttagcacat gaaggataga      1898
 Asp 


 t                                                                   1899




      <210> 125
      <211> 1997
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(843)

      <400> 125
 tttcgttgct ggtggacctg ctctggtggt cttggatgag gcccc    atg agc gcg      54
                                                      Met Ser Ala
                                                        1

 gcg ccc ctg gtg ggc tac agc agc agc ggc tcc gag gat gag tcc gag      102
 Ala Pro Leu Val Gly Tyr Ser Ser Ser Gly Ser Glu Asp Glu Ser Glu
       5                  10                  15

 gac ggg atg cgg acc agg ccg ggg gat ggg agc cac cgt cgt ggc cag      150
 Asp Gly Met Arg Thr Arg Pro Gly Asp Gly Ser His Arg Arg Gly Gln
  20                  25                  30                  35

 agc ccc ctt ccc agg cag aga ttt cca gta cct gac agt gtg ctg aac      198
 Ser Pro Leu Pro Arg Gln Arg Phe Pro Val Pro Asp Ser Val Leu Asn
                  40                  45                  50

 atg ttc ccg ggc acc gag gag ggg cct gaa gat gac agc aca aaa cac      246
 Met Phe Pro Gly Thr Glu Glu Gly Pro Glu Asp Asp Ser Thr Lys His
              55                  60                  65

 ggg gga cgg gtg cgc acc ttc ccc cac gag cga ggc aac tgg gcc acc      294
 Gly Gly Arg Val Arg Thr Phe Pro His Glu Arg Gly Asn Trp Ala Thr
          70                  75                  80

 cac gtc tat gta cca tat gaa gcc aag gag gag ttc ctg gat ctg ctt      342
 His Val Tyr Val Pro Tyr Glu Ala Lys Glu Glu Phe Leu Asp Leu Leu
      85                  90                  95

 gat gtg ttg ctg ccc cat gcc cag aca tat gtc ccc cgg ctg gta agg      390
 Asp Val Leu Leu Pro His Ala Gln Thr Tyr Val Pro Arg Leu Val Arg
 100                 105                 110                 115

 atg aag gtg ttc cac ctc agc ctg tcc cag agt gtg gtt ctg cgc cac      438
 Met Lys Val Phe His Leu Ser Leu Ser Gln Ser Val Val Leu Arg His
                 120                 125                 130

 cac tgg atc ctc ccc ttc gtg cag gct ctg aaa gcc cgt atg acc tcc      486
 His Trp Ile Leu Pro Phe Val Gln Ala Leu Lys Ala Arg Met Thr Ser
             135                 140                 145

 ttc cac aga ttc ttc ttt act gcc aac cag gta aag att tac acc aat      534
 Phe His Arg Phe Phe Phe Thr Ala Asn Gln Val Lys Ile Tyr Thr Asn
         150                 155                 160

 caa gag aaa acc agg acc ttt att ggg ctt gag gtc act tca ggg cat      582
 Gln Glu Lys Thr Arg Thr Phe Ile Gly Leu Glu Val Thr Ser Gly His
     165                 170                 175

 gcc cag ttc ctg gac ctg gtt tca gag gtg gac cga gtc atg gag gaa      630
 Ala Gln Phe Leu Asp Leu Val Ser Glu Val Asp Arg Val Met Glu Glu
 180                 185                 190                 195

 ttc aac ctc acc act ttc tac cag gat cct tct ttc cac ctc agc ctg      678
 Phe Asn Leu Thr Thr Phe Tyr Gln Asp Pro Ser Phe His Leu Ser Leu
                 200                 205                 210

 gcc tgg tgt gtg ggt gat gca cgt ctc cag ctg gag ggg cag tgc ctg      726
 Ala Trp Cys Val Gly Asp Ala Arg Leu Gln Leu Glu Gly Gln Cys Leu
             215                 220                 225

 cag gaa cta cag gca atc gtg gat ggg ttt gaa gat gct gag gtg ctg      774
 Gln Glu Leu Gln Ala Ile Val Asp Gly Phe Glu Asp Ala Glu Val Leu
         230                 235                 240

 ctg cgc gtg cac act gag caa gtc cgc tgc aag tct ggg aac aag ttc      822
 Leu Arg Val His Thr Glu Gln Val Arg Cys Lys Ser Gly Asn Lys Phe
     245                 250                 255

 ttc tcg atg cct ttg aag tga gc accagaggcc ttcctcctcc agggccctct      875
 Phe Ser Met Pro Leu Lys 
 260                 265

 gcagaccagg ctgagatgga ggaacctgct aaaatcgatg gagatgcttc tagcctccca    935

 gtaggaggcc ccagccatgc cttcaacctg gcaggaggtg tagccactcc tcatcctccc    995

 tgagtgctga tattctctct ctctctttct cttcctcttc tttctctctc ttctcctctc   1055

 tttctctcct ctgtctctct tcctctcctc tcttcctctc ttctctcttc ctctcctctc   1115

 tctcttcctc ttctctctct tcccctcctg tctctcctcc cctcctctct ctcttcctct   1175

 cctctctctt cctctcctct ctctacccct cctgtctctc ctcccctcct ctctcttcct   1235

 ctcctctctc tcttcctctc ctctctcttc ccttcctgtc tctcttcccc tcctctctct   1295

 cttcctgtcc tctatctctt cccctcctct atctcttcct ctcctctctc tcttcctctc   1355

 ctctctctct cttcctttct tctctctctc ctgtctcggc tgttgtgggt tgcaggttgg   1415

 gtgctgctgt tgtggtcctt cccagaaact gccagtagag ggcagcctgg gcatcctaat   1475

 gcttactctg gttgttacac aaagaaaata ttggggtcac tggcgagccc acccacactc   1535

 accagaatct ccactgtagt ccccctaaca aacagccctt cacttcctct tccacttcag   1595

 caatttgtat tttgatgcca ttggcctcag atcagagtgt tttaaatcat cacgccctgg   1655

 cttatccctg gtcgagccag gacacggggt gcttcagtgg gtctgtcacc ctctctcctt   1715

 gaagcatgtt gcttttattt atttactttt actctcaccc tgctcctgta ccagcagggg   1775

 ccacttcaaa gccaaggtac agggtgataa cttgtggtcc agcatcagtt ttctccactt   1835

 ctttctccca ctcaccccca gcaaggtgcc tggggagact tgagcagatg tttcattttg   1895

 gcctggccag tggctgaaag ccaggcctcc aatgcactgt gacctctggc ttccccagca   1955

 gctttcccag agaggcagag gggccttcca cagcccgggt tc                      1997




      <210> 126
      <211> 1019
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(972)

      <400> 126
 atgtcccgcc ctcgc atg cgc ctg gtg gtc acc gcg gac gac ttt ggt tac      51
                  Met Arg Leu Val Val Thr Ala Asp Asp Phe Gly Tyr
                    1               5                  10

 tgc ccg cga cgc gat gag ggt atc gtg gag gcc ttt ctg gcc ggg gcc       99
 Cys Pro Arg Arg Asp Glu Gly Ile Val Glu Ala Phe Leu Ala Gly Ala
          15                  20                  25

 gtg acc agc gtg tcc ctg ctg gtc aac ggt gcg gcc acg gag agc gcg      147
 Val Thr Ser Val Ser Leu Leu Val Asn Gly Ala Ala Thr Glu Ser Ala
      30                  35                  40

 gcg gag ctg gcc cgc agg cac agc atc ccc acg ggc ctc cac gcc aac      195
 Ala Glu Leu Ala Arg Arg His Ser Ile Pro Thr Gly Leu His Ala Asn
  45                  50                  55                  60

 ctg tcc gag ggc cgc ccc gtg ggt ccg gcc cgc cgt ggc gcc tca tcg      243
 Leu Ser Glu Gly Arg Pro Val Gly Pro Ala Arg Arg Gly Ala Ser Ser
                  65                  70                  75

 ctg ctc ggc ccg gaa ggc ttc ttc ctt ggc aag atg gga ttc cgg gag      291
 Leu Leu Gly Pro Glu Gly Phe Phe Leu Gly Lys Met Gly Phe Arg Glu
              80                  85                  90

 gcg gtg gcg gcc gga gac gtg gat ttg cct cag gtg cgg gag gag ctc      339
 Ala Val Ala Ala Gly Asp Val Asp Leu Pro Gln Val Arg Glu Glu Leu
          95                 100                 105

 gag gcc caa cta agc tgc ttc cgg gag ctg ctg ggc agg gcc ccc acg      387
 Glu Ala Gln Leu Ser Cys Phe Arg Glu Leu Leu Gly Arg Ala Pro Thr
     110                 115                 120

 cac gcg gac ggg cac cag cac gtg cac gtg ctc cca ggc gtg tgc cag      435
 His Ala Asp Gly His Gln His Val His Val Leu Pro Gly Val Cys Gln
 125                 130                 135                 140

 gtg ttc gcc gag gcg ctg cag gcc tat ggg gtg cgc ttt acg cga ctg      483
 Val Phe Ala Glu Ala Leu Gln Ala Tyr Gly Val Arg Phe Thr Arg Leu
                 145                 150                 155

 ccg ctg gag cgc ggt gtg ggt ggc tgc act tgg ctg gag gcc ccc gcg      531
 Pro Leu Glu Arg Gly Val Gly Gly Cys Thr Trp Leu Glu Ala Pro Ala
             160                 165                 170

 cgt gcc ttc gcc tgc gcc gtg gag cgc gac gcc cgg gcc gcc gtg ggc      579
 Arg Ala Phe Ala Cys Ala Val Glu Arg Asp Ala Arg Ala Ala Val Gly
         175                 180                 185

 ccc ttc tcc cgc cac ggc ctg cgg tgg aca gac gcc ttc gtg ggc ctg      627
 Pro Phe Ser Arg His Gly Leu Arg Trp Thr Asp Ala Phe Val Gly Leu
     190                 195                 200

 agc act tgc ggc cgg cac atg tcc gct cac cgc gtg tcc ggg gcc ctg      675
 Ser Thr Cys Gly Arg His Met Ser Ala His Arg Val Ser Gly Ala Leu
 205                 210                 215                 220

 gcg cgg gtc ctg gaa ggt acc cta gcg ggc cac acc ctg aca gcc gag      723
 Ala Arg Val Leu Glu Gly Thr Leu Ala Gly His Thr Leu Thr Ala Glu
                 225                 230                 235

 ctg atg gcg cac ccc ggc tac ccc agt gtg cct ccc acc ggc ggc tgc      771
 Leu Met Ala His Pro Gly Tyr Pro Ser Val Pro Pro Thr Gly Gly Cys
             240                 245                 250

 ggt gaa ggc ccc gac gct ttc tct tgc tct tgg gag cgg ctg cat gag      819
 Gly Glu Gly Pro Asp Ala Phe Ser Cys Ser Trp Glu Arg Leu His Glu
         255                 260                 265

 ctg cgc gtc ctc acc gcg ccc acg ctg cgg gcc cag ctt gcc cag gat      867
 Leu Arg Val Leu Thr Ala Pro Thr Leu Arg Ala Gln Leu Ala Gln Asp
     270                 275                 280

 ggc gtg cag ctt tgc gcc ctc gac gac ctg gac tcc aag agg cca ggg      915
 Gly Val Gln Leu Cys Ala Leu Asp Asp Leu Asp Ser Lys Arg Pro Gly
 285                 290                 295                 300

 gag gag gtc ccc tgt gag ccc act ctg gaa ccc ttc ctg gaa ccc tcc      963
 Glu Glu Val Pro Cys Glu Pro Thr Leu Glu Pro Phe Leu Glu Pro Ser
                 305                 310                 315

 cta ctc tga cccccta cagacaacca agcactaatc cccttagtac caagaaaggg     1019
 Leu Leu 






      <210> 127
      <211> 1729
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (255)..(1073)

      <400> 127
 gttcggcacg aggggcactg gaggtcgcga gcacgttgct agtgggcgcg gctggcgggg     60

 ccgggggcgg cagggggcta gcgtccggct gagcccggcg ggttcctgca cgcggaccca    120

 cgctttgtcg ggctgctctg ctgagtgaca ccgccgtggc atccgaggag ctgtggtcca    180

 gcctgcgcgg cgggaagcgg cggcggcggc tccagcgtcc taagagaagc tgaaacctat    240

 caacactctt caaa  atg caa tgg aat gta cca cgg act gta tct cga ctg     290
                  Met Gln Trp Asn Val Pro Arg Thr Val Ser Arg Leu
                    1               5                  10

 gca cgc agg aca tgc ttg gaa cca cat aat gct ggt ctc ttt gga cac      338
 Ala Arg Arg Thr Cys Leu Glu Pro His Asn Ala Gly Leu Phe Gly His
          15                  20                  25

 tgt caa aat gta aag gga cct tta ctt tta tac aat gct gaa tcc aaa      386
 Cys Gln Asn Val Lys Gly Pro Leu Leu Leu Tyr Asn Ala Glu Ser Lys
      30                  35                  40

 gtg gtt ttg gta caa ggc cct caa aaa caa tgg ttg cat tta tct gct      434
 Val Val Leu Val Gln Gly Pro Gln Lys Gln Trp Leu His Leu Ser Ala
  45                  50                  55                  60

 gcc cag tgt gtt gca aag gaa agg agg cca ttg gat gct cat cca ccc      482
 Ala Gln Cys Val Ala Lys Glu Arg Arg Pro Leu Asp Ala His Pro Pro
                  65                  70                  75

 caa cca gga gtc ctt cgc cat aag caa ggg aag caa cat gtt tca ttc      530
 Gln Pro Gly Val Leu Arg His Lys Gln Gly Lys Gln His Val Ser Phe
              80                  85                  90

 agg agg gtt ttt tca tcc agt gcc aca gct cag gga act ccg gaa aaa      578
 Arg Arg Val Phe Ser Ser Ser Ala Thr Ala Gln Gly Thr Pro Glu Lys
          95                 100                 105

 aag gaa gag cct gat cct ttg caa gac aaa tct att agt ctt tat caa      626
 Lys Glu Glu Pro Asp Pro Leu Gln Asp Lys Ser Ile Ser Leu Tyr Gln
     110                 115                 120

 cga ttc aag aag aca ttt aga cag tat gga aaa gtt ctg att cca gtg      674
 Arg Phe Lys Lys Thr Phe Arg Gln Tyr Gly Lys Val Leu Ile Pro Val
 125                 130                 135                 140

 cat cta ata act tct ggt gtt tgg ttt gga aca ttt tat tat gca gcc      722
 His Leu Ile Thr Ser Gly Val Trp Phe Gly Thr Phe Tyr Tyr Ala Ala
                 145                 150                 155

 ttg aaa gga gtg aat gtc gtt cct ttt cta gaa ctc att ggg tta cct      770
 Leu Lys Gly Val Asn Val Val Pro Phe Leu Glu Leu Ile Gly Leu Pro
             160                 165                 170

 gac agt gtg gta agc atc ctg aaa aac tcc cag agt gga aat gcc ctc      818
 Asp Ser Val Val Ser Ile Leu Lys Asn Ser Gln Ser Gly Asn Ala Leu
         175                 180                 185

 aca gca tat gcc ttg ttt aag att gca aca cct gct cgg tat acc gtg      866
 Thr Ala Tyr Ala Leu Phe Lys Ile Ala Thr Pro Ala Arg Tyr Thr Val
     190                 195                 200

 act ttg gga gga aca tct gtc act gtg aag tat ctg cgc agt cat ggc      914
 Thr Leu Gly Gly Thr Ser Val Thr Val Lys Tyr Leu Arg Ser His Gly
 205                 210                 215                 220

 tac atg tcc acg ccg cca ccc gtc aag gag tat ctg cag gac agg atg      962
 Tyr Met Ser Thr Pro Pro Pro Val Lys Glu Tyr Leu Gln Asp Arg Met
                 225                 230                 235

 gaa gag aca aag gag ctt atc aca gag aaa atg gaa gaa aca aaa gat     1010
 Glu Glu Thr Lys Glu Leu Ile Thr Glu Lys Met Glu Glu Thr Lys Asp
             240                 245                 250

 aga ctc act gaa aag tta caa gaa acc aaa gaa aaa gtt tcc ttt aag     1058
 Arg Leu Thr Glu Lys Leu Gln Glu Thr Lys Glu Lys Val Ser Phe Lys
         255                 260                 265

 aaa aaa gtg gaa taa ggtgccttat atagcagtat agaaaattcc tgcactttaa     1113
 Lys Lys Val Glu 
     270

 ccctttggaa actatgggca aagatacatg tgtctgatta tttttttggt tagttgccga   1173

 aatatactag ttctctgagg gttaaagaag taaaatacct ttttaaagtt aaatatcact   1233

 agaaaaatca gtgttattac aagggaagaa atgaacccag tttaagaatt tgccatcagt   1293

 agcagtatta agcagtggtt aatgtcttag aagtcagact tctttttcaa ggtcttcaga   1353

 accacacttg atttctgttt tgttgcagct gtaattgaca cataaaatag tctgttaata   1413

 ccggatctta atttttatgt tattcattaa gattttaact atattcagta cgtaatttgg   1473

 agacaaacta gcatcatcaa aactgcctgt aaataaggtg tttagtcttt ctataaaaac   1533

 agaatagagc agttacctac cagttaaaat atcttatatg aagaaaatag aataaagatc   1593

 cagtcatata tgtaaataag atgtactgat tgtacgtaaa tgaaaaatgg accctttaaa   1653

 aattattttt acctgaagct tgtcataatt tttttaaagc aaatatatat atggtgatgg   1713

 taaaaaaaaa aaaaaa                                                   1729




      <210> 128
      <211> 1057
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (102)..(362)

      <400> 128
 attctttgtt tctaatttac acctagcagg ctaaccctgc tggcacctgc agtgcttcca     60

 gggggaaagg accatagtgt gcccctgtga agagtctcag a    atg gtg cgg aag     113
                                                  Met Val Arg Lys
                                                    1

 gtg aat gcc cac ctc ccg ctc tct ttt ccc act gta gaa act gat tcc      161
 Val Asn Ala His Leu Pro Leu Ser Phe Pro Thr Val Glu Thr Asp Ser
   5                  10                  15                  20

 aga gaa att ctc caa gtg cgg tgc tat gtg ggc ttg cgg gag agg tgt      209
 Arg Glu Ile Leu Gln Val Arg Cys Tyr Val Gly Leu Arg Glu Arg Cys
                  25                  30                  35

 tat gat caa aca gaa cca ttc tct tta ccc tct gtt cat ggt ttt tct      257
 Tyr Asp Gln Thr Glu Pro Phe Ser Leu Pro Ser Val His Gly Phe Ser
              40                  45                  50

 tgg ctc tgt ggt cca gtg agt tgt cac agc ttc act ccc aat ttc tgg      305
 Trp Leu Cys Gly Pro Val Ser Cys His Ser Phe Thr Pro Asn Phe Trp
          55                  60                  65

 gat att cag ggc aat aat ctt gcc act ggg tat ttg cta gtt gaa att      353
 Asp Ile Gln Gly Asn Asn Leu Ala Thr Gly Tyr Leu Leu Val Glu Ile
      70                  75                  80

 atg tgg tag ggagaga agccagtaag cttcacttct ccgtttggct gatgtcactc      409
 Met Trp 
  85

 tcgaattctg tactttcata cggattgtaa tagggagggt ctaaaaggaa gcttcagttt    469

 tggattttta gagcttcttc taagtacaat tgttgaatca agaggtaaaa atggtatgtt    529

 ataactggaa atacgctgag attaaaaagg agataaatta gccccattgg gacagtgcta    589

 ttgggaatgt gaattgatac cactttcctg gagtctagtt tagtatttat tttatatgta    649

 atgcctgaaa agatgtgtgt ctcctttgac tcaatactta taggaattta cacaaaggtt    709

 ataatcaaag attatagaac tgttatactg gaaaaacacg aaatattcta attatgaatt    769

 aattggggat tggttaaata aactatggtt tgatatgctc taaaaataat gttacagaaa    829

 aaagtgtact gatatggcaa aatgtatgac ttatagttaa aaaagcaggt tagatgttga    889

 tagatacagt atgatagaaa aagatcagga aggtatatgc tgacatttaa atctggatat    949

 ttatgagtgt tttttttatt tcaatctttg tacatgcatg tattttctag aaattgtatt   1009

 actatctttg taataaagta aattattttt aagggactaa aaaaaaaa                1057




      <210> 129
      <211> 708
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (9)..(512)

      <400> 129
 gcggggag atg gat aaa ctg acc atc atc tca gga tgt ctc ttt ctg gcc      50
          Met Asp Lys Leu Thr Ile Ile Ser Gly Cys Leu Phe Leu Ala
            1               5                  10

 gcc gat atc ttc gcc atc gcc agc atc gcc aac ccg gac tgg atc aac       98
 Ala Asp Ile Phe Ala Ile Ala Ser Ile Ala Asn Pro Asp Trp Ile Asn
  15                  20                  25                  30

 acc ggg gag tct gcg gga gca ctc act gtg ggc ctc gtg cga cag tgt      146
 Thr Gly Glu Ser Ala Gly Ala Leu Thr Val Gly Leu Val Arg Gln Cys
                  35                  40                  45

 caa aca atc cat gga cga gac cgg acg tgc atc cct ccc cgg ctt ccc      194
 Gln Thr Ile His Gly Arg Asp Arg Thr Cys Ile Pro Pro Arg Leu Pro
              50                  55                  60

 ccg gag tgg gtc acc aca ctg ttt ttt atc atc atg gga atc att tca      242
 Pro Glu Trp Val Thr Thr Leu Phe Phe Ile Ile Met Gly Ile Ile Ser
          65                  70                  75

 ttg act gtc aca tgt ggt ttg ctg gtg gct tcc cac tgg cga aga gaa      290
 Leu Thr Val Thr Cys Gly Leu Leu Val Ala Ser His Trp Arg Arg Glu
      80                  85                  90

 gct aca aaa tat gct cga tgg ata gca ttc act gga atg atc ctt ttc      338
 Ala Thr Lys Tyr Ala Arg Trp Ile Ala Phe Thr Gly Met Ile Leu Phe
  95                 100                 105                 110

 tgt atg gct gcc cta ata ttt cca ata gga ttt tac atc aat gaa gtc      386
 Cys Met Ala Ala Leu Ile Phe Pro Ile Gly Phe Tyr Ile Asn Glu Val
                 115                 120                 125

 gga ggt caa cct tat aaa tta ccc aac aac aca gta gtt ggg tca tca      434
 Gly Gly Gln Pro Tyr Lys Leu Pro Asn Asn Thr Val Val Gly Ser Ser
             130                 135                 140

 tat gta ctt ttt gtc tta tca att ttc ttt aca ata gta gga ctt cta      482
 Tyr Val Leu Phe Val Leu Ser Ile Phe Phe Thr Ile Val Gly Leu Leu
         145                 150                 155

 ttt gct ggc aaa gtt tgt tta cca ggc tga t gaatgtctaa attgcttgac      533
 Phe Ala Gly Lys Val Cys Leu Pro Gly 
     160                 165

 tcttattatt ttttatttta ttttattttt ttatttttgg agggtggaga ggacaaaggc    593

 gaggcatctg agcaggcctc tcatgggaag atgctcagat gaaactgatg ctgagaagga    653

 aaaaaaaatg ctttggtttg ttctcactat gcactttgga tttaaaaaaa aaaaa         708




      <210> 130
      <211> 617
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (400)..(588)

      <400> 130
 atcattacgc catgcttggc acgaggctct ccatgtggag atggaaggta gagaaggata     60

 cagtgtctat cctcaagttg ctacggttca gtgagagagg cagacatctg aacaggcagg    120

 taggattcag tgtgctcagt gcactgggga tttggagaga gatgggcttg ctctctctgt    180

 gcacccagga gggccacgca cttaaaactg tgtttgtgga tcagagaagg ctttatagca    240

 cagggggcat tcagatgagt cttagaggaa gagaagaaac atggcaagca gattacatct    300

 gagccgtttg aattgtgttt ttctttcttc ccatgtttat tttctaagat ctacctgaac    360

 ttagagactc aagatatttt tttaggaaac ctcctaccc   atg tct gag gta gca     414
                                              Met Ser Glu Val Ala
                                                1               5

 agt gca gcc tca cga cag ata cca ggc aat cca gag cca caa aac gtg      462
 Ser Ala Ala Ser Arg Gln Ile Pro Gly Asn Pro Glu Pro Gln Asn Val
                  10                  15                  20

 att cct cca ggc tct gcc tgg cct gac cct gtc ctg tca gct ggg ttt      510
 Ile Pro Pro Gly Ser Ala Trp Pro Asp Pro Val Leu Ser Ala Gly Phe
              25                  30                  35

 aca tac cag tcc cat tct tcc ttt tca ata cct acc ccc aaa tct tct      558
 Thr Tyr Gln Ser His Ser Ser Phe Ser Ile Pro Thr Pro Lys Ser Ser
          40                  45                  50

 cct aac cac cat ctg gtt ttt ttt ttt taa a gcattttttg ctttaaaagc      609
 Pro Asn His His Leu Val Phe Phe Phe 
      55                  60

 atcctgac                                                             617




      <210> 131
      <211> 1716
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (80)..(1201)

      <400> 131
 gaaaacctgt gtgtttccta ctgccgattc agctgtcagc ctttccagtt ccagggatca     60

 gaatactact tctcctggt atg aat agc agt gat gaa ttg tgt gag agt gtt     112
                      Met Asn Ser Ser Asp Glu Leu Cys Glu Ser Val
                        1               5                  10

 tca gta cat ccg ctc cag atg act gga ttg act gat att gca gac att      160
 Ser Val His Pro Leu Gln Met Thr Gly Leu Thr Asp Ile Ala Asp Ile
              15                  20                  25

 att gat gac ctt ata att aaa gac gga gtt tcc agt gaa gaa ctt ggc      208
 Ile Asp Asp Leu Ile Ile Lys Asp Gly Val Ser Ser Glu Glu Leu Gly
          30                  35                  40

 tta aca gaa caa gct atg ggc acc tcc aga att cag cat tat tct ggc      256
 Leu Thr Glu Gln Ala Met Gly Thr Ser Arg Ile Gln His Tyr Ser Gly
      45                  50                  55

 aga cat tca caa aga act gac aag gaa aga aga gag att caa gcc tgg      304
 Arg His Ser Gln Arg Thr Asp Lys Glu Arg Arg Glu Ile Gln Ala Trp
  60                  65                  70                  75

 atg aaa aga aaa cga aaa gaa aga atg gca aag tac tta aat gag ctg      352
 Met Lys Arg Lys Arg Lys Glu Arg Met Ala Lys Tyr Leu Asn Glu Leu
                  80                  85                  90

 gca gaa aag aga ggg caa gaa cat gat cct ttc tgt ccc aga agc aat      400
 Ala Glu Lys Arg Gly Gln Glu His Asp Pro Phe Cys Pro Arg Ser Asn
              95                 100                 105

 cca ctt tac atg act tca agg gaa ata agg ctg aga caa aag atg aag      448
 Pro Leu Tyr Met Thr Ser Arg Glu Ile Arg Leu Arg Gln Lys Met Lys
         110                 115                 120

 cat gaa aaa gac aga ttg ctg ctc tct gaa cac tat agt cgt cga atc      496
 His Glu Lys Asp Arg Leu Leu Leu Ser Glu His Tyr Ser Arg Arg Ile
     125                 130                 135

 tca caa gcg tac ggt ctg atg aat gaa ctg tta tct gag tca gta cag      544
 Ser Gln Ala Tyr Gly Leu Met Asn Glu Leu Leu Ser Glu Ser Val Gln
 140                 145                 150                 155

 cta cca act cta cca cag aaa cca ttg cct aac aaa ccc agc cct act      592
 Leu Pro Thr Leu Pro Gln Lys Pro Leu Pro Asn Lys Pro Ser Pro Thr
                 160                 165                 170

 cag tct tcc agt tgt caa cac tgc cct tct cca aga gga gag aat caa      640
 Gln Ser Ser Ser Cys Gln His Cys Pro Ser Pro Arg Gly Glu Asn Gln
             175                 180                 185

 cat ggt cac agt ttt cta ata aat cga cct gga aaa gtc aaa tat atg      688
 His Gly His Ser Phe Leu Ile Asn Arg Pro Gly Lys Val Lys Tyr Met
         190                 195                 200

 tcc aaa ccg agt tat atc cat aag agg aag tct ttt ggg caa cct caa      736
 Ser Lys Pro Ser Tyr Ile His Lys Arg Lys Ser Phe Gly Gln Pro Gln
     205                 210                 215

 ggc tca cct tgg cca cat gga act gcc act ttc acc ata cag aaa aaa      784
 Gly Ser Pro Trp Pro His Gly Thr Ala Thr Phe Thr Ile Gln Lys Lys
 220                 225                 230                 235

 gct ggt gga gcc aaa gca gca gta aga aag gct acg cag tct cca gtt      832
 Ala Gly Gly Ala Lys Ala Ala Val Arg Lys Ala Thr Gln Ser Pro Val
                 240                 245                 250

 acc ttc caa aaa ggc tct aat gct ccg tgt cat agt ctg cag cat aca      880
 Thr Phe Gln Lys Gly Ser Asn Ala Pro Cys His Ser Leu Gln His Thr
             255                 260                 265

 aaa aaa cat gga agt gct ggg ctt gca cct caa acc aag cag gtg tgt      928
 Lys Lys His Gly Ser Ala Gly Leu Ala Pro Gln Thr Lys Gln Val Cys
         270                 275                 280

 gta gag tat gaa aga gag gag act gtg gtg agt ccc tgg acg ata cct      976
 Val Glu Tyr Glu Arg Glu Glu Thr Val Val Ser Pro Trp Thr Ile Pro
     285                 290                 295

 tca gaa atc cat aag att ctt cat gag agt cac aat tcc ctt cta caa     1024
 Ser Glu Ile His Lys Ile Leu His Glu Ser His Asn Ser Leu Leu Gln
 300                 305                 310                 315

 gac ttg tct cca act gaa gag gaa gag cca gag cat cct ttt ggg gtg     1072
 Asp Leu Ser Pro Thr Glu Glu Glu Glu Pro Glu His Pro Phe Gly Val
                 320                 325                 330

 ggc ggt gtg gac agc gtg tct gag agc act ggc agc atc ctc agc aag     1120
 Gly Gly Val Asp Ser Val Ser Glu Ser Thr Gly Ser Ile Leu Ser Lys
             335                 340                 345

 ctg gac tgg aat gcc atc gaa gac atg gtg gcc agc gtg gag gac cag     1168
 Leu Asp Trp Asn Ala Ile Glu Asp Met Val Ala Ser Val Glu Asp Gln
         350                 355                 360

 ggc ctg tct gtc cac tgg gcc ctg gac ctg taa gacctgga tatcattggg     1219
 Gly Leu Ser Val His Trp Ala Leu Asp Leu 
     365                 370

 tttccatgca caggccagca cctcagtaat gtggttctga aagattaaca ggtttaaggg   1279

 acagaagcaa tgaaagaagc aatgtgaatt ttccatttgc tttcatatta ttacctggat   1339

 tagccattac cagaggaaaa ataaacattt ctcagtaact ttgcctttat ggggaaaggg   1399

 ttgactattg atgtattata tgtttttgta tttgatgcat cattaggcat aatttttaaa   1459

 atgataagta cctttcaagc caagtttgca taacctactt tcaataaaaa ccctctatct   1519

 tgcctcctcc tttattaccc tctgagtttt gagaaacaac catatacaga tgaatctaat   1579

 aggaaaaaaa aaaatctttt cattgagaag aaaatcagtc tcacctgaga actcaattat   1639

 gaaccctatt ttaaaacacc tatgcagggt ttagcctagg agtgaaaaga aaaaccaact   1699

 accttttacc aaccctg                                                  1716




      <210> 132
      <211> 846
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (319)..(690)

      <400> 132
 ggaaagtgag ggggttgcgc gcccgagtgc accaggctgc ctgtgaggcc gaaaggggag     60

 gccgcccccg gccccgcgcc ccctgccccg gaggcgaccc ctccgccggc ctcggccgcg    120

 gggaaggact gggcgttcat caacaccaac atctttgcca ggaccaagat agaccccagc    180

 gccttggtgc agaagctgga gctggacgtg aggagtgtca cttccgtcag gagaggtgag    240

 gcaggctcga gtgcacggag cgtcccttcc atcaggagag gtgcagaggc caagaccgtt    300

 ttgcccaaga aggagaaa  atg aag ctg agg cgt gag caa tgg ttg cag aaa     351
                      Met Lys Leu Arg Arg Glu Gln Trp Leu Gln Lys
                        1               5                  10

 atc gaa gcc ata aaa ctg gct gag cag aag cac agg gag gag cgg agg      399
 Ile Glu Ala Ile Lys Leu Ala Glu Gln Lys His Arg Glu Glu Arg Arg
              15                  20                  25

 cgg agg gcc acg gtg gtg gtg ggg gac ctg cac cct ctc agg gat gcc      447
 Arg Arg Ala Thr Val Val Val Gly Asp Leu His Pro Leu Arg Asp Ala
          30                  35                  40

 ctg ccc gag ctg ctg ggg ctc gag gct ggc agc cgg cgc caa gcc cgc      495
 Leu Pro Glu Leu Leu Gly Leu Glu Ala Gly Ser Arg Arg Gln Ala Arg
      45                  50                  55

 agc agg gag agc aac aag ccc cgg ccc tca gag ctc agc cgg atg agc      543
 Ser Arg Glu Ser Asn Lys Pro Arg Pro Ser Glu Leu Ser Arg Met Ser
  60                  65                  70                  75

 gca gcc cag aga cag cag ctt ctc gag gaa gaa agg acc cgg ttt cag      591
 Ala Ala Gln Arg Gln Gln Leu Leu Glu Glu Glu Arg Thr Arg Phe Gln
                  80                  85                  90

 gag ctg ctg gcc agt ccg gcc tac aga gcc agc ccc ctg gtg gcc atc      639
 Glu Leu Leu Ala Ser Pro Ala Tyr Arg Ala Ser Pro Leu Val Ala Ile
              95                 100                 105

 ggg cag acg ctg gcc cgg cag atg cag ctg gaa gat ggc ggc cag ctc      687
 Gly Gln Thr Leu Ala Arg Gln Met Gln Leu Glu Asp Gly Gly Gln Leu
         110                 115                 120

 tga ccag ggcagcgggc atgccacaac tcctcaggac acatgtgggc caagtagaga      744
 


 gcgccggccc ctcaaggacc atggcctgag cctggtggac gcccttccct ctggtcggtt    804

 gtggggctca ataaatggct ctgtgaactt caaaaaaaaa aa                       846




      <210> 133
      <211> 1096
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (187)..(687)

      <400> 133
 tcagagcaaa tgttttatta acagattttt ctccagtagt cttgaaaatc tcccctgggg     60

 gagaaaactg gcaaaagggg gcctgagggt tgttggaaga aatgaaaagt acataggatg    120

 ctattttgaa gaactgattt gtcagaagcc actttatttt aacaataatg tgactgcacc    180

 tggcac   atg aga cag gct ctg ggc ctg ttt ctc aat gtt gtg aaa agc     228
          Met Arg Gln Ala Leu Gly Leu Phe Leu Asn Val Val Lys Ser
            1               5                  10

 agg aca gtc agt tcc cat gga gta gat tac agc gtg ttg gac aag gac      276
 Arg Thr Val Ser Ser His Gly Val Asp Tyr Ser Val Leu Asp Lys Asp
  15                  20                  25                  30

 att ccc ccg cgt gaa ggc aca ctc cat gga gcc agt ggg gcc acc att      324
 Ile Pro Pro Arg Glu Gly Thr Leu His Gly Ala Ser Gly Ala Thr Ile
                  35                  40                  45

 cac ggt gtg caa gct gtg gcc ttg gag aga aca tgg gca ggg ctt ccc      372
 His Gly Val Gln Ala Val Ala Leu Glu Arg Thr Trp Ala Gly Leu Pro
              50                  55                  60

 cag cct cta cta tac ccc agc ttt act cca ttg atc aca aca atg gca      420
 Gln Pro Leu Leu Tyr Pro Ser Phe Thr Pro Leu Ile Thr Thr Met Ala
          65                  70                  75

 ctt ttt tct ttt ggt gca aat att tcc att ttc caa ttg agc cta gac      468
 Leu Phe Ser Phe Gly Ala Asn Ile Ser Ile Phe Gln Leu Ser Leu Asp
      80                  85                  90

 ttt gat ttt ata aaa gga aaa gag aat atc tat ata tgt aaa tat ctg      516
 Phe Asp Phe Ile Lys Gly Lys Glu Asn Ile Tyr Ile Cys Lys Tyr Leu
  95                 100                 105                 110

 cat gtg agt gta tgt gta tat ata tgt ata tat ata tgt ata tac gca      564
 His Val Ser Val Cys Val Tyr Ile Cys Ile Tyr Ile Cys Ile Tyr Ala
                 115                 120                 125

 ttt ata gat aaa att att atg gtt gca gaa gca tca aat ttt gta aaa      612
 Phe Ile Asp Lys Ile Ile Met Val Ala Glu Ala Ser Asn Phe Val Lys
             130                 135                 140

 ata tct gtt tac tac aag cct ctt ttc aag cac act tat gac aca gaa      660
 Ile Ser Val Tyr Tyr Lys Pro Leu Phe Lys His Thr Tyr Asp Thr Glu
         145                 150                 155

 aat att cag aga tta aat tgc cca tga atcta gtgctcagag gaaaatagtt      712
 Asn Ile Gln Arg Leu Asn Cys Pro 
     160                 165

 tgacaaattg gaccaatgaa gttgaaattg gatcatagaa gttcaaaata tttacaaagt    772

 gtcatctttt gtaatgtgta tcacaggact ttgaattcct tgggaaaatg agacaatttt    832

 tttgtggctt gtgtaggtct gattttcact gtggatcacc ctttatattt tccttctttc    892

 aactccttcc ttctcctgca agttcataac attttattaa tatcaaagga aggttataat    952

 tttagaaatc aaaattaaag aatgggtgct gtgtagcatt atgtttactg ggcttgatat   1012

 aatcagtact tttggcataa tttaaaacat gattatactg tgtgtcattg gatatgtata   1072

 tagacacaac atgttctcta tcaa                                          1096




      <210> 134
      <211> 1999
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (366)..(1892)

      <400> 134
 caaaataaaa ggaaaaccac tgtgtaaaac agtaggcgga tctttcagag actccaaatc     60

 attgacaatt cagaaggatc ttgtcgctgc atttgacaac ggagaccaga aggtgttctt    120

 cgatctgtgg gaggagcaca tttcaagttc catccgagat ggggactcct ttgcccagaa    180

 gctggaattc tatctccaca tccattttgc catctatctt ttgaagtact ctgtggggag    240

 accggacaaa gaggagctgg atgaaaagat ttcctacttc aaaacctacc tggagaccaa    300

 aggggcagcc ttgagccaga cacagagttt cttcctttct atgcccttcc tttgttccca    360

 accct    atg gtg cac ccc tca ttt aaa gaa ctc ttc cag gat tcc tgg     407
          Met Val His Pro Ser Phe Lys Glu Leu Phe Gln Asp Ser Trp
            1               5                  10

 act cca gag tta aag ttg aag ttg gaa aag ttt cta gct tta ata tct      455
 Thr Pro Glu Leu Lys Leu Lys Leu Glu Lys Phe Leu Ala Leu Ile Ser
  15                  20                  25                  30

 aaa gcc agc aac acg cca aag ctt tta aca ata tat aag gag aat gga      503
 Lys Ala Ser Asn Thr Pro Lys Leu Leu Thr Ile Tyr Lys Glu Asn Gly
                  35                  40                  45

 caa agt aac aaa gaa atc ttg cag cag ctc cac cag cag ctg gtt gaa      551
 Gln Ser Asn Lys Glu Ile Leu Gln Gln Leu His Gln Gln Leu Val Glu
              50                  55                  60

 gct gaa cgt agg tca gtg aca tac ctc aaa cgg tac aat aag atc cag      599
 Ala Glu Arg Arg Ser Val Thr Tyr Leu Lys Arg Tyr Asn Lys Ile Gln
          65                  70                  75

 gcc gac tac cac aat ctc att gga gtc aca gca gag ctg gtg gat tct      647
 Ala Asp Tyr His Asn Leu Ile Gly Val Thr Ala Glu Leu Val Asp Ser
      80                  85                  90

 cta gag gcc aca gtc agc ggc aag atg atc acc cct gag tac ctc cag      695
 Leu Glu Ala Thr Val Ser Gly Lys Met Ile Thr Pro Glu Tyr Leu Gln
  95                 100                 105                 110

 agc gtc tgt gtc cgc ctg ttc agt aac cag atg cgg cag agc ctg gcg      743
 Ser Val Cys Val Arg Leu Phe Ser Asn Gln Met Arg Gln Ser Leu Ala
                 115                 120                 125

 cat agt gtg gac ttc acg agg cct ggg acg gca tcc acc atg tta cga      791
 His Ser Val Asp Phe Thr Arg Pro Gly Thr Ala Ser Thr Met Leu Arg
             130                 135                 140

 gcc tcc ttg gca ccc gtg aaa ttg aag gat gtc cca tta ctg ccc tcc      839
 Ala Ser Leu Ala Pro Val Lys Leu Lys Asp Val Pro Leu Leu Pro Ser
         145                 150                 155

 ttg gat tat gag aaa ctg aag aag gat ttg att ttg ggg agt gac cgc      887
 Leu Asp Tyr Glu Lys Leu Lys Lys Asp Leu Ile Leu Gly Ser Asp Arg
     160                 165                 170

 ttg aaa gcc ttc ttg ttg cag gct ctg cgc tgg cgc ttg acc aca tcc      935
 Leu Lys Ala Phe Leu Leu Gln Ala Leu Arg Trp Arg Leu Thr Thr Ser
 175                 180                 185                 190

 cat cct gga gag cag agg gag acc gtt ctg caa gcc tac atc agc aat      983
 His Pro Gly Glu Gln Arg Glu Thr Val Leu Gln Ala Tyr Ile Ser Asn
                 195                 200                 205

 gac ctc ttg gac tgt tat agc cac aac cag agg agt gtg ctt cag ttg     1031
 Asp Leu Leu Asp Cys Tyr Ser His Asn Gln Arg Ser Val Leu Gln Leu
             210                 215                 220

 ctg cac tcc acg agc gac gtg gtg cgg cag tac atg gcc agg ctc atc     1079
 Leu His Ser Thr Ser Asp Val Val Arg Gln Tyr Met Ala Arg Leu Ile
         225                 230                 235

 aat gct ttt gcg tca ctg gca gaa ggt cgc ctc tac ctt gcc cag aac     1127
 Asn Ala Phe Ala Ser Leu Ala Glu Gly Arg Leu Tyr Leu Ala Gln Asn
     240                 245                 250

 aca aag gtg ctg cag atg ctg gag gga agg ctg aag gag gag gac aag     1175
 Thr Lys Val Leu Gln Met Leu Glu Gly Arg Leu Lys Glu Glu Asp Lys
 255                 260                 265                 270

 gat atc atc acc agg gag aat gtt ctt ggg gcc ctg cag aag ttc agt     1223
 Asp Ile Ile Thr Arg Glu Asn Val Leu Gly Ala Leu Gln Lys Phe Ser
                 275                 280                 285

 ctc agg cgc ccg ctg cag aca gcg atg att caa gac ggc ctc atc ttc     1271
 Leu Arg Arg Pro Leu Gln Thr Ala Met Ile Gln Asp Gly Leu Ile Phe
             290                 295                 300

 tgg ctg gtt gat gtt ctg aag gac cct gac tgc ctg tct gac tac acg     1319
 Trp Leu Val Asp Val Leu Lys Asp Pro Asp Cys Leu Ser Asp Tyr Thr
         305                 310                 315

 ctg gag tac tcg gtg gct ttg ctc atg aac ctc tgc ctc cgc agc aca     1367
 Leu Glu Tyr Ser Val Ala Leu Leu Met Asn Leu Cys Leu Arg Ser Thr
     320                 325                 330

 ggg aag aac atg tgt gcc aag gtg gca ggc ctc gtg ctc aaa gtc ctt     1415
 Gly Lys Asn Met Cys Ala Lys Val Ala Gly Leu Val Leu Lys Val Leu
 335                 340                 345                 350

 tcg gat ctt ctt ggc cat gaa aac cat gag ata cag ccg tat gtg aat     1463
 Ser Asp Leu Leu Gly His Glu Asn His Glu Ile Gln Pro Tyr Val Asn
                 355                 360                 365

 gga gct ctg tac agc atc ctt tct gtt cca tcc att cgt gag gaa gca     1511
 Gly Ala Leu Tyr Ser Ile Leu Ser Val Pro Ser Ile Arg Glu Glu Ala
             370                 375                 380

 aga gca atg gga atg gaa gac atc cta cgc tgc ttc atc aaa gaa ggc     1559
 Arg Ala Met Gly Met Glu Asp Ile Leu Arg Cys Phe Ile Lys Glu Gly
         385                 390                 395

 aat gct gaa atg atc cgc cag ata gaa ttc atc atc aag cag cta aat     1607
 Asn Ala Glu Met Ile Arg Gln Ile Glu Phe Ile Ile Lys Gln Leu Asn
     400                 405                 410

 tcc gaa gag cta cca gat ggt gtt ctt gaa tct gat gat gat gaa gat     1655
 Ser Glu Glu Leu Pro Asp Gly Val Leu Glu Ser Asp Asp Asp Glu Asp
 415                 420                 425                 430

 gaa gat gat gaa gag gac cat gac atc atg gaa gcc gat ctg gac aaa     1703
 Glu Asp Asp Glu Glu Asp His Asp Ile Met Glu Ala Asp Leu Asp Lys
                 435                 440                 445

 gac gaa ctg atc cag ccc cag ctc gga gaa ctc tca gga gag aag ctt     1751
 Asp Glu Leu Ile Gln Pro Gln Leu Gly Glu Leu Ser Gly Glu Lys Leu
             450                 455                 460

 ctg acc acg gag tac ctg ggg atc atg acc aac acg ggg aag aca agg     1799
 Leu Thr Thr Glu Tyr Leu Gly Ile Met Thr Asn Thr Gly Lys Thr Arg
         465                 470                 475

 cgg aag ggg ctg gct aat gtg cag tgg agc ggg gat gag ccc ctg caa     1847
 Arg Lys Gly Leu Ala Asn Val Gln Trp Ser Gly Asp Glu Pro Leu Gln
     480                 485                 490

 agg ccc gtc acc ccc ggc ggc cac aga aac ggg tac cca gtg taa gtc     1895
 Arg Pro Val Thr Pro Gly Gly His Arg Asn Gly Tyr Pro Val 
 495                 500                 505

 agggctaaag gaagcgggaa ttgactttct taagctttgt tttgattaca gtgtaagatg   1955

 tatgtatttt taaaattcaa aataaagcat tcattttgaa aagc                    1999




      <210> 135
      <211> 798
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (242)..(547)

      <400> 135
 atgatcgcct gcggaccgga ttgaattcct ggacgaccca cgcgtccggc ctatccgcct     60

 tcccaaaccc tcccattccc ccggggtagc cccccccttc actttccttc tcgtcctctg    120

 gggttctcct ctcttctttc ttcccttccc cctctagcat tgctaccttc tctcctacac    180

 gcacgcaggc atataaacgt aggtttttga tgctcctctg cctgttgacc ccgctatttt    240

 c    atg ttt cca aca ggt ttt tct tcc ccc agt ccc tca gct gct gct     286
      Met Phe Pro Thr Gly Phe Ser Ser Pro Ser Pro Ser Ala Ala Ala
        1               5                  10                  15

 gct gct cag gag gtc aga tct gcc act gat ggt aat acc agc acc act      334
 Ala Ala Gln Glu Val Arg Ser Ala Thr Asp Gly Asn Thr Ser Thr Thr
                  20                  25                  30

 ccg ccc acc tct gcc aag aag aga aag gta aca gta gta acg aga gag      382
 Pro Pro Thr Ser Ala Lys Lys Arg Lys Val Thr Val Val Thr Arg Glu
              35                  40                  45

 aag act ttg att cca cct ctt cct cct ctt cca ctc ctc ctt tac aac      430
 Lys Thr Leu Ile Pro Pro Leu Pro Pro Leu Pro Leu Leu Leu Tyr Asn
          50                  55                  60

 cca ggg att cgg cat ccc ctt caa cct cgt cct tct gcc tgg ggg ttt      478
 Pro Gly Ile Arg His Pro Leu Gln Pro Arg Pro Ser Ala Trp Gly Phe
      65                  70                  75

 cag tgg ctg ctt cca gcc acg tac cga tac aga aga agc tgc gtt ttg      526
 Gln Trp Leu Leu Pro Ala Thr Tyr Arg Tyr Arg Arg Ser Cys Val Leu
  80                  85                  90                  95

 aaa aca ccc tgg agt ttg tag gg tttgatgcga agatggctga ggaatcctcc      579
 Lys Thr Pro Trp Ser Leu 
                 100

 tcctcctcct cctcatcttc accaactgct gcaacatctc agcagcagca acttaaaaat    639

 aagagtatat taatctcttc tgtggcttcg gtgcatcatg caaacggcct agccaaatct    699

 tctaccaccg tctctagctt tgctaacagc aacctggctc tgctaagaag ttagtgatca    759

 gaactttaaa gataagccta aattaccaga aaactgcac                           798




      <210> 136
      <211> 501
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (68)..(457)

      <400> 136
 ttaaccttgg acagtggttg tccctgtcac ttttgtccag ctctggctcg tgttttgtgg     60

 gacaggt  atg aac tcc gac agc ttg ggt cct ccc tgc ccc cac aca gcc     109
          Met Asn Ser Asp Ser Leu Gly Pro Pro Cys Pro His Thr Ala
            1               5                  10

 acc gcc tcc ggc agc cgc ccc atc tcc gcc cct tcc ggc cag ccg ggg      157
 Thr Ala Ser Gly Ser Arg Pro Ile Ser Ala Pro Ser Gly Gln Pro Gly
  15                  20                  25                  30

 ctc atg gct cag atg gcg tcc atg gcc gca ggg gta gcc gtg ggc tcg      205
 Leu Met Ala Gln Met Ala Ser Met Ala Ala Gly Val Ala Val Gly Ser
                  35                  40                  45

 gct gtg gga cac gtc atg ggc agc gcc ctg acc gga gcc ttc agc ggg      253
 Ala Val Gly His Val Met Gly Ser Ala Leu Thr Gly Ala Phe Ser Gly
              50                  55                  60

 ggg agc tcg gag ccc gtc cag cct gct gtc cag cag gcc ccc acc ccc      301
 Gly Ser Ser Glu Pro Val Gln Pro Ala Val Gln Gln Ala Pro Thr Pro
          65                  70                  75

 gct gcc ccc cag ccc ctg cag atg ggg ccc tgc gcc tat gag atc agg      349
 Ala Ala Pro Gln Pro Leu Gln Met Gly Pro Cys Ala Tyr Glu Ile Arg
      80                  85                  90

 cag ttc ctg gac tgt tcc acc act cag agt gac ctg tcc ctg tgt gag      397
 Gln Phe Leu Asp Cys Ser Thr Thr Gln Ser Asp Leu Ser Leu Cys Glu
  95                 100                 105                 110

 ggc ttc agc gag gcc ctg aag cag tgc aag tac tac cat ggt ctg agc      445
 Gly Phe Ser Glu Ala Leu Lys Gln Cys Lys Tyr Tyr His Gly Leu Ser
                 115                 120                 125

 tcc ctg ccc tga aga ggtcggtgca gactcggggg ccagtcctgc acccacctct      500
 Ser Leu Pro 


 a                                                                    501




      <210> 137
      <211> 3274
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (960)..(2690)

      <400> 137
 ttttggcccc aattctgggt tctccccaag gcccaggttt cttccccttt ctacaaatct     60

 ttatttcttc ctttgacctt caccaccacc caaagtactt ttaattctag aaaagaaacc    120

 cagttgcaca ctggcacacc tgactttcaa gcagtcagaa gctttggatg attccccatc    180

 caaaatatta gagatgaaat gaaagcaaag taggcatctg acaaaagttg cttttccctt    240

 ctgcatttta ggacctcaag taatgtttat ccagaaactg ctatcatacc agggattcat    300

 tgtgtattta acaacatagg catgcaatct ggcaaatttg aaaaactctt aacatacacc    360

 ccaaatccct gcccaaattt aagaactagg gtggacacag tgcgtttttc catgtcgcat    420

 cttctgtgat ggggctacga tacgtgggag cagagaatgg ggagggtgga gcgcatgcca    480

 gatgaggatc tatcagcaat gggacggggc ctccacttta gcatctccac cctgctcctc    540

 tcagaggacc gcctttcatt gcattcagct gtgatggtag cacgaacaca ggtgcaccga    600

 ggacgaggag agcaggagcc ttgtgctctc tctgcatctg aggcaggaca gcacagggta    660

 cggagcagtc tgcagagagg ccagctcatc agggaagcac ttgtcttcca ccttgggctt    720

 tgactgagca ctgggcaatt ggcctctggg gatcaacgaa ataatcctaa acagagttac    780

 tctatgtcac actatggaat gttccaagta ggtggccgtg ttttcaaaag atgtattttc    840

 tccttttgtt gttgccattt cataggttta ggattgggtg tgtgtttctc ctctctgaat    900

 ggcactcgaa tgtttgctga ctcctactct gtgtgactgg ggtgtacagc tatggactg     959                                                                 
 atg cat ccc atc cca tca tct ttc atg atc aaa gca gtc tct tct ttt     1007
 Met His Pro Ile Pro Ser Ser Phe Met Ile Lys Ala Val Ser Ser Phe
   1               5                  10                  15

 ttg aca gct gaa gaa gca tcg gta ggg aat cca gaa gga gcg ttc atg     1055
 Leu Thr Ala Glu Glu Ala Ser Val Gly Asn Pro Glu Gly Ala Phe Met
              20                  25                  30

 aag gtg tta caa gcc cgg aag aac tac aca agc act gag ctg att gtt     1103
 Lys Val Leu Gln Ala Arg Lys Asn Tyr Thr Ser Thr Glu Leu Ile Val
          35                  40                  45

 gag cca gag gag ccc tca gac agc agt ggc atc aac ttg tca ggc ttt     1151
 Glu Pro Glu Glu Pro Ser Asp Ser Ser Gly Ile Asn Leu Ser Gly Phe
      50                  55                  60

 ggg agt gag cag cta gac acc aat gac gag agt gat ttt atc agt aca     1199
 Gly Ser Glu Gln Leu Asp Thr Asn Asp Glu Ser Asp Phe Ile Ser Thr
  65                  70                  75                  80

 cta agt tac atc ttg cct tat ttc tca gcg gta aac cta gat gtg aaa     1247
 Leu Ser Tyr Ile Leu Pro Tyr Phe Ser Ala Val Asn Leu Asp Val Lys
                  85                  90                  95

 tca ctg tta cta ccg tta att aaa ctg cca acc aca gga aac agc ctg     1295
 Ser Leu Leu Leu Pro Leu Ile Lys Leu Pro Thr Thr Gly Asn Ser Leu
             100                 105                 110

 gca aag att caa act gta ggc caa aac cgg cag aga gtg aag aga gtc     1343
 Ala Lys Ile Gln Thr Val Gly Gln Asn Arg Gln Arg Val Lys Arg Val
         115                 120                 125

 ctc atg ggc cca agg agc atc cag aaa agg cac ttc aaa gag gta gga     1391
 Leu Met Gly Pro Arg Ser Ile Gln Lys Arg His Phe Lys Glu Val Gly
     130                 135                 140

 agg cag agc atc agg agg gaa cag ggt gcc cag gca tct gtg gag aac     1439
 Arg Gln Ser Ile Arg Arg Glu Gln Gly Ala Gln Ala Ser Val Glu Asn
 145                 150                 155                 160

 gct gcc gaa gaa aaa agg ctc ggg agt cca gcc cca agg gag gtg gaa     1487
 Ala Ala Glu Glu Lys Arg Leu Gly Ser Pro Ala Pro Arg Glu Val Glu
                 165                 170                 175

 cag ccc cac aca cag cag ggg cct gag aag tta gcg gga aac gcc gtc     1535
 Gln Pro His Thr Gln Gln Gly Pro Glu Lys Leu Ala Gly Asn Ala Val
             180                 185                 190

 tac acc aag cct tcc ttc acc caa gag cat aag gca gca gtc tct gtg     1583
 Tyr Thr Lys Pro Ser Phe Thr Gln Glu His Lys Ala Ala Val Ser Val
         195                 200                 205

 ctg aaa ccc ttc tcc aag ggc gcg cct tct acc tcc agc cct gca aaa     1631
 Leu Lys Pro Phe Ser Lys Gly Ala Pro Ser Thr Ser Ser Pro Ala Lys
     210                 215                 220

 gcc cta cca cag gtg aga gac aga tgg aaa gac tta acc cac gct att     1679
 Ala Leu Pro Gln Val Arg Asp Arg Trp Lys Asp Leu Thr His Ala Ile
 225                 230                 235                 240

 tcc att tta gaa agt gca aag gct aga gtt aca aat acg aag acg tct     1727
 Ser Ile Leu Glu Ser Ala Lys Ala Arg Val Thr Asn Thr Lys Thr Ser
                 245                 250                 255

 aaa cca atc gta cat gcc aga aaa aaa tac cgc ttt cac aaa act cgc     1775
 Lys Pro Ile Val His Ala Arg Lys Lys Tyr Arg Phe His Lys Thr Arg
             260                 265                 270

 tcc cac gtg acc cac aga aca ccc aaa gtc aaa aag agt cca aag gtc     1823
 Ser His Val Thr His Arg Thr Pro Lys Val Lys Lys Ser Pro Lys Val
         275                 280                 285

 aga aag aaa agt tat ctg agt aga ctg atg ctc gca aac agg ctt cca     1871
 Arg Lys Lys Ser Tyr Leu Ser Arg Leu Met Leu Ala Asn Arg Leu Pro
     290                 295                 300

 ttc tct gca gcg aag agc ctc ata aat tcc cct tca caa ggg gct ttt     1919
 Phe Ser Ala Ala Lys Ser Leu Ile Asn Ser Pro Ser Gln Gly Ala Phe
 305                 310                 315                 320

 tca tcc tta gga gac ctg agt cct caa gaa aac cct ttt ctg gaa gta     1967
 Ser Ser Leu Gly Asp Leu Ser Pro Gln Glu Asn Pro Phe Leu Glu Val
                 325                 330                 335

 tct gct cct tca gaa cat ttt ata gaa aac aat aat aca aaa cac aca     2015
 Ser Ala Pro Ser Glu His Phe Ile Glu Asn Asn Asn Thr Lys His Thr
             340                 345                 350

 act gca aga aat gcc ttt gaa gaa aat gat ttt atg gaa aac act aac     2063
 Thr Ala Arg Asn Ala Phe Glu Glu Asn Asp Phe Met Glu Asn Thr Asn
         355                 360                 365

 atg cca gaa gga acc atc tct gaa aac aca aac tac aat cat cct cat     2111
 Met Pro Glu Gly Thr Ile Ser Glu Asn Thr Asn Tyr Asn His Pro His
     370                 375                 380

 gag gca gat tcc gct ggg act gca ttc aac tta ggg cca act gtt aaa     2159
 Glu Ala Asp Ser Ala Gly Thr Ala Phe Asn Leu Gly Pro Thr Val Lys
 385                 390                 395                 400

 caa act gag aca aaa tgg gaa tac aac aac gtg ggc act gac ctg tcc     2207
 Gln Thr Glu Thr Lys Trp Glu Tyr Asn Asn Val Gly Thr Asp Leu Ser
                 405                 410                 415

 ccc gag ccc aaa agc ttc aat tac cca ttg ctc tcg tcc cca ggt gat     2255
 Pro Glu Pro Lys Ser Phe Asn Tyr Pro Leu Leu Ser Ser Pro Gly Asp
             420                 425                 430

 cag ttt gaa att cag cta acc cag cag cta cag tcc ctt atc ccc aac     2303
 Gln Phe Glu Ile Gln Leu Thr Gln Gln Leu Gln Ser Leu Ile Pro Asn
         435                 440                 445

 aac aat gtg aga agg ctc att gct cat gtt atc cgg acc ttg aag atg     2351
 Asn Asn Val Arg Arg Leu Ile Ala His Val Ile Arg Thr Leu Lys Met
     450                 455                 460

 gac tgc tct ggg gcc cat gtg caa gtg acc tgt gcc aag ctc atc tcc     2399
 Asp Cys Ser Gly Ala His Val Gln Val Thr Cys Ala Lys Leu Ile Ser
 465                 470                 475                 480

 agg aca ggc cac ctg atg aag ctt ctc agt ggg cag cag gaa gta aag     2447
 Arg Thr Gly His Leu Met Lys Leu Leu Ser Gly Gln Gln Glu Val Lys
                 485                 490                 495

 gca tcc aag ata gaa tgg gat acg gac caa tgg aag att gag aac tac     2495
 Ala Ser Lys Ile Glu Trp Asp Thr Asp Gln Trp Lys Ile Glu Asn Tyr
             500                 505                 510

 att aat gag agc aca gaa gcc cag agt gaa cag aaa gag aag tcg ctt     2543
 Ile Asn Glu Ser Thr Glu Ala Gln Ser Glu Gln Lys Glu Lys Ser Leu
         515                 520                 525

 gag gat gga ctt tcc tca ttt gga cag ccg ctc tgg ttt aaa gat atg     2591
 Glu Asp Gly Leu Ser Ser Phe Gly Gln Pro Leu Trp Phe Lys Asp Met
     530                 535                 540

 tac aaa cct ctc agt gcc aca aga ata aat aat cat gca tgg aag ctg     2639
 Tyr Lys Pro Leu Ser Ala Thr Arg Ile Asn Asn His Ala Trp Lys Leu
 545                 550                 555                 560

 cac aag aag tca tct aat gag gac gag atc ctc aac agg gac cct ggg     2687
 His Lys Lys Ser Ser Asn Glu Asp Glu Ile Leu Asn Arg Asp Pro Gly
                 565                 570                 575

 taa atga cgggaccctc acagttccca tctaaaatga ggagggggtg agacgcttaa     2744
 


 ttgctccttt caagaatgaa aaccttggca ttgttattct tatcccaggg acagtgaagc   2804

 cccaacagag aaggaggagg agagtgaagc cctgccatag gaggagaacc cagcccacct   2864

 caggcctcct gcaaaaacac atagcataaa caataccatc agaaagaaaa gcaggactga   2924

 agccagcagc ccacacatcc acagaggcag cgggcagagc aagcacaggg ccatcgttcc   2984

 tgcccttgtt tcccagtcta attagtcacc cagacctgaa aacatatcct cagggggtgg   3044

 agattttaca attaaatacc attgtttttg gtgccctctc cctgggttca tcaagcacca   3104

 gtcatataat accacatact tgaactcctg cccacagggg acctcccatc tcctggcccc   3164

 tattatagga tcactgggcc tacctgcact gtggggccaa gccctgtctt tttcccaagc   3224

 cctcaagcac acgcatgaat gttcatcccg acttggtagg gggcctcgtg              3274




      <210> 138
      <211> 466
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (85)..(375)

      <400> 138
 ttgcacaaaa tacggccgag gaggagtgtg aaaataaaaa tctcttttca tgcagtttct     60

 gcttcatttt ccaaggatta taat   atg ctg agt aaa ctt ttg gca cta agg     111
                              Met Leu Ser Lys Leu Leu Ala Leu Arg
                                1               5

 aag cca gct aca ggc cac gta atg aaa act att cag aaa aca gtt cag      159
 Lys Pro Ala Thr Gly His Val Met Lys Thr Ile Gln Lys Thr Val Gln
  10                  15                  20                  25

 caa ata cta cta ttt gaa tac agt tca aat cgt att tat ata aat act      207
 Gln Ile Leu Leu Phe Glu Tyr Ser Ser Asn Arg Ile Tyr Ile Asn Thr
                  30                  35                  40

 ctg cct aca tta ttt aac cca aac tgg att att cac cat tct ttg aag      255
 Leu Pro Thr Leu Phe Asn Pro Asn Trp Ile Ile His His Ser Leu Lys
              45                  50                  55

 atg cct tgt gtt ttc tgt tat cta ctt ctg ctc gtg cag ttt act tac      303
 Met Pro Cys Val Phe Cys Tyr Leu Leu Leu Leu Val Gln Phe Thr Tyr
          60                  65                  70

 acc ttc acc ctt tca aat cct aac tct tct tca agg cct gat tca gat      351
 Thr Phe Thr Leu Ser Asn Pro Asn Ser Ser Ser Arg Pro Asp Ser Asp
      75                  80                  85

 ttt aac ttt tta aag gct atc tga atcattcaag gagaagatac cctttctctc     405
 Phe Asn Phe Leu Lys Ala Ile 
  90                  95

 ataaaaacac ttagagcaaa ctaccactat taaatcactt attgcatact gaaaaaaaaa    465

 a                                                                    466




      <210> 139
      <211> 910
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (434)..(748)

      <400> 139
 cgacccacgc ggccgtgttt ccctctgcct atctatctgc ctgggtctct tgcttctctc     60

 tggccaacca gctttctcat tagggcatat gtagctgaaa aatccacccc tcaagaaccc    120

 actccacaca acctttcctt ttcagtaccc accacgctct gactagcatc tctgtgatgc    180

 ctaaggcaaa tttttgagga tctgattggt ttagttcatc tgcctatggg ggagccaccc    240

 tggggtcagg tgcctgtcca atcacctgtt accaaggagg cagggccgtg tcatttaagc    300

 atggccccat ggactgaccc tttcagcagg gacttttatt gggggctggt acccagaaga    360

 aggagcatga gtgggcaaga ccttcaaaaa gaacctacta cacactggaa ctgactagta    420

 ctcctgggat gcc   atg cca cgc agc agc cag cac tcg gag agc agt ccc     469
                  Met Pro Arg Ser Ser Gln His Ser Glu Ser Ser Pro
                    1               5                  10

 ctg gat act acc aca cag aga aaa ggg gca tct tca ctt gca cat cag      517
 Leu Asp Thr Thr Thr Gln Arg Lys Gly Ala Ser Ser Leu Ala His Gln
          15                  20                  25

 gtg agg gtg cac aca ctt gaa act ctg cta gac tgg cca gag ctg ccc      565
 Val Arg Val His Thr Leu Glu Thr Leu Leu Asp Trp Pro Glu Leu Pro
      30                  35                  40

 cag cca ctt ctc acc cca cca cca gtt att gat aca gcc gct ggg tct      613
 Gln Pro Leu Leu Thr Pro Pro Pro Val Ile Asp Thr Ala Ala Gly Ser
  45                  50                  55                  60

 agg aag cga ttt ctg aac aag gcc cag tta gca caa tgt ctt gct cag      661
 Arg Lys Arg Phe Leu Asn Lys Ala Gln Leu Ala Gln Cys Leu Ala Gln
                  65                  70                  75

 cag aca ata aat act tgt aaa ttg aat tgc atg atc tta gct cag gtg      709
 Gln Thr Ile Asn Thr Cys Lys Leu Asn Cys Met Ile Leu Ala Gln Val
              80                  85                  90

 cta cta atg tgg ctc acg gcc aca cac ttg cat gga taa gaaaaccaat       758
 Leu Leu Met Trp Leu Thr Ala Thr His Leu His Gly 
          95                 100

 gagcccctca acagagtctt ttgaaacaaa attggtttca agtgaaactt acattatttt    818

 ttggctgtga ccttctgaat ataataactt agtgtcctga gaattgaaag gcctcttgat    878

 ttcttaagtg aactgttaca gaatcctagc ct                                  910




      <210> 140
      <211> 1670
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (272)..(784)

      <400> 140
 gcacgagcgg cacgagccaa actcacagct gcccctgtgc acgcttcaga gttgagctgg     60

 ggtctcagtc tccaacctgt cctttctgac cctcccatgg ctgcccaggg agggcggggt    120

 tcactgtgcc acgtgctggg tgcccccctc tgcagacagc cagtccagga gatggaccaa    180

 cagaggtcaa ggggcagctg gccaggccgc accggggtcc ccgagttctg agctgtgcta    240

 tgcaaacaag aatgctcctg tgtggggggg c   atg gcc gtt gga ggt ata gct     292
                                      Met Ala Val Gly Gly Ile Ala
                                        1               5

 ggg cgg gta gtg gaa gga ctg gaa atc tct gtt gtt gtt tgg gga agt      340
 Gly Arg Val Val Glu Gly Leu Glu Ile Ser Val Val Val Trp Gly Ser
          10                  15                  20

 cca tgc ttc agt cct tcg gag tat gcg tgg att gtt cga agt gtg act      388
 Pro Cys Phe Ser Pro Ser Glu Tyr Ala Trp Ile Val Arg Ser Val Thr
      25                  30                  35

 atg gcc cgg gag cca ggg cag cat gaa ctc ctt tct ctg aaa ttt cga      436
 Met Ala Arg Glu Pro Gly Gln His Glu Leu Leu Ser Leu Lys Phe Arg
  40                  45                  50                  55

 ggc ctc ctt ggg ttc cct gaa ctc cgg gct gat gtt ccc agg acc cag      484
 Gly Leu Leu Gly Phe Pro Glu Leu Arg Ala Asp Val Pro Arg Thr Gln
                  60                  65                  70

 cac cag gag acc cca gtc ccg cca gca gcc gcc gct acc cag gag ggc      532
 His Gln Glu Thr Pro Val Pro Pro Ala Ala Ala Ala Thr Gln Glu Gly
              75                  80                  85

 tgg gcg aca ttg gcc gcc tcc cac cag ctc ccc ctc ctc gcc cac agc      580
 Trp Ala Thr Leu Ala Ala Ser His Gln Leu Pro Leu Leu Ala His Ser
          90                  95                 100

 ctc ttg tca ctg cca agc ccc cgt tcc ttt tgc cca aat cac gca ggc      628
 Leu Leu Ser Leu Pro Ser Pro Arg Ser Phe Cys Pro Asn His Ala Gly
     105                 110                 115

 gga agc tgc agt gcc agc tgg agg gat gtt cat agg gct tcc tgt gcc      676
 Gly Ser Cys Ser Ala Ser Trp Arg Asp Val His Arg Ala Ser Cys Ala
 120                 125                 130                 135

 cat ccc tgc tcc aaa cag ctg gac agc ttc ccc tct acc ccc acc ctg      724
 His Pro Cys Ser Lys Gln Leu Asp Ser Phe Pro Ser Thr Pro Thr Leu
                 140                 145                 150

 gtg agc ccc tgg ggg cca gag aaa gat ggg gtt cct gca cct tcc cag      772
 Val Ser Pro Trp Gly Pro Glu Lys Asp Gly Val Pro Ala Pro Ser Gln
             155                 160                 165

 ctc cac ctc tga act tgagttagcg ttagctaagc atacaatcag tgtcgaacgt      827
 Leu His Leu 
         170

 ctctcttcct taagcttgta gatacgactg cctataatca ggggactccc actggaggcc    887

 gggaggccaa tgctggccag gtgcgagggc atggtttggt tcctttaggg aatttttgtt    947

 ttgcaaacag gagaaacctg tgctgcaggt tggagtggca ggaacgactg gccttggtca   1007

 gcaggcagcc cccagcctag ggccacagtc ctcttcaggg cctgggcagc cccaatttct   1067

 ggcccagcag gtttctcttt gtagtgtctt tcagcacatc caaaatgcta ggcctcctgc   1127

 caccaacgtg tcagagcaat gtccaactgt caggctctca gagatgcctc agtttcccta   1187

 gcatgagcac cagccgacac acacagtcca ctgagatgat aattctgttc tctccaaagc   1247

 aaaaagctgg gcgaggggta gtctcaattt ctgtcagtgc tcaaaggaat aacaccaaaa   1307

 gaatcaacac agaatctccc agacacacgt gacccagctc gtggcgccgt gggtccgtag   1367

 gagggacagt acctcacaac aggcccagcg ggggaccacc tctctgtaca attggaacgc   1427

 gttttacttt tcttttctct ccttttttca ttccgatttt ttttgcatgt ttctttttga   1487

 aatgggcaaa atgtgtagca gcctgcatga gcacagttgt tttggggaaa gatactggag   1547

 tatgatgtac tcacacctgc aaatctgagc atcgcgaggt taaacgttcc accttttttt   1607

 gtaatcgtca acagcacaac tattttgtat tgttgtttgt atcattttgt accaaaaaaa   1667

 aaa                                                                 1670




      <210> 141
      <211> 1109
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (709)..(1062)

      <400> 141
 cgggggtcag aagagagaac gggtggcctt tcttccacgc gagaaaatcg cactctagtg     60

 gccgtagaac ttgggcagaa gtagatggag gccctggctg ggaggacccg cccagcaagg    120

 gggaatgaat tggggtccca cttaaagaag cagtaggact atgcttcaac aaaacagcca    180

 tggcatgctg gggaaccacc tctgcccaaa tctgcttgga ctctccaaac cctcaggctt    240

 aaatggctta gtcccccaaa cagccaaggt ggcagggcgc ccctccacca tgggcattcc    300

 atcccagaga gaaatcagaa ctctgttcat agaatatggg tggggcagct ggaggcccct    360

 gctgggagaa ctcacacagt gagggaaatg gattggggtc ccatttaaag aagaagtctg    420

 gcaacatttt ggtaaagcag ctgtgctgtg ctgtggggtc cctgcctcat tcagatcatt    480

 tggactctcc aaagcccaca ggctgcaatg actttgtcat ccgaacagca aatatggcag    540

 cccatccctc acccagaagc tctgacccat ctcaggcagg tgctacactg ttaccagtaa    600

 ctagctggaa ttccaaatct gtgggtctta tcttgtgaag tgccatggaa gtgggatcca    660

 caaactgatg ctgctcagcc tcctggattc agcccccttc ctaggggt atg cac caa     717
                                                      Met His Gln
                                                        1

 tct ccc acc ttg cct gag ttg cag tca tct ttg ttg gat gtc cca ggg      765
 Ser Pro Thr Leu Pro Glu Leu Gln Ser Ser Leu Leu Asp Val Pro Gly
       5                  10                  15

 ctg acg tat gta aag ctc ctg gga ctc tgt ttg tgt ctg agc agc tgt      813
 Leu Thr Tyr Val Lys Leu Leu Gly Leu Cys Leu Cys Leu Ser Ser Cys
  20                  25                  30                  35

 tct acc aag act cca cac agc tct gtg tgt cag acc caa gac cct ggt      861
 Ser Thr Lys Thr Pro His Ser Ser Val Cys Gln Thr Gln Asp Pro Gly
                  40                  45                  50

 gga gtg ggt tca caa ctg aat cgc ctg atg caa ggg ttg caa aga tct      909
 Gly Val Gly Ser Gln Leu Asn Arg Leu Met Gln Gly Leu Gln Arg Ser
              55                  60                  65

 ttg aga gaa gtg tgg ttt cct ggg gtt gca cat tca ctc acc att ttt      957
 Leu Arg Glu Val Trp Phe Pro Gly Val Ala His Ser Leu Thr Ile Phe
          70                  75                  80

 ctt ggc tgg ggt ggg ggt tcc ttt ggc tct gta tca atc ctg ggt ggg     1005
 Leu Gly Trp Gly Gly Gly Ser Phe Gly Ser Val Ser Ile Leu Gly Gly
      85                  90                  95

 acc tca aaa tca att ctt atg gta atg cca tat tgt ttg gtt agt ata     1053
 Thr Ser Lys Ser Ile Leu Met Val Met Pro Tyr Cys Leu Val Ser Ile
 100                 105                 110                 115

 aca ttt tag taagaat atcagaaata aatttcattt ttgttttcaa aattctcatg     1109
 Thr Phe 






      <210> 142
      <211> 1735
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (173)..(1597)

      <400> 142
 agcttggcgc gccagtgcct cggtttccag gctccgggaa taacagaagc cagctgagag     60

 cgcctgcgcg gctgtcggtt gatggggagg tcaggtctgg gaaactaggc cctggggttt    120

 tccctgagca ggagcggggc ccgagggcct caggcgtcag tccaggccct ga    atg     175
                                                              Met
                                                                1

 gct ggt ctc cag cgg ttg gcg tca cat ctg cct gtg ggc gtt atg ctc      223
 Ala Gly Leu Gln Arg Leu Ala Ser His Leu Pro Val Gly Val Met Leu
               5                  10                  15

 cca cat aat aca acg gaa gct cca ggg ccc cac tca gcc aag caa gac      271
 Pro His Asn Thr Thr Glu Ala Pro Gly Pro His Ser Ala Lys Gln Asp
          20                  25                  30

 tct tat gaa caa ggt gac tct tcc cag cag tcc ttg aag ggg cac ctg      319
 Ser Tyr Glu Gln Gly Asp Ser Ser Gln Gln Ser Leu Lys Gly His Leu
      35                  40                  45

 agg aac aat ttc cag aag cag ctt ttg agc aac aaa gag ttg att ctg      367
 Arg Asn Asn Phe Gln Lys Gln Leu Leu Ser Asn Lys Glu Leu Ile Leu
  50                  55                  60                  65

 gat aaa gtc tat act cac ccc aaa tgg aac acc caa aca aaa gcc cgg      415
 Asp Lys Val Tyr Thr His Pro Lys Trp Asn Thr Gln Thr Lys Ala Arg
                  70                  75                  80

 agc tac tcc tat ccc cac tgt act gga atc agc cag caa gat cca gaa      463
 Ser Tyr Ser Tyr Pro His Cys Thr Gly Ile Ser Gln Gln Asp Pro Glu
              85                  90                  95

 agt gat tcc cag ggc caa gga aat ggt ttg ttt tac tcg tca ggc cct      511
 Ser Asp Ser Gln Gly Gln Gly Asn Gly Leu Phe Tyr Ser Ser Gly Pro
         100                 105                 110

 caa tcc tgg tat ccc aaa gcc aat aac cag gac ttt atc ccc ttt aca      559
 Gln Ser Trp Tyr Pro Lys Ala Asn Asn Gln Asp Phe Ile Pro Phe Thr
     115                 120                 125

 aag aaa cga gtt gga gtg gac cgg gcg ttc cca ttg aaa ccc atg gtc      607
 Lys Lys Arg Val Gly Val Asp Arg Ala Phe Pro Leu Lys Pro Met Val
 130                 135                 140                 145

 cac agg aag tcg tgc agt aca ggt gag gct ggc act gat ggg gac cat      655
 His Arg Lys Ser Cys Ser Thr Gly Glu Ala Gly Thr Asp Gly Asp His
                 150                 155                 160

 aat gtc tac cca agg ccc cct gag ccg aga gag ttt tca tct agg aac      703
 Asn Val Tyr Pro Arg Pro Pro Glu Pro Arg Glu Phe Ser Ser Arg Asn
             165                 170                 175

 ttt ggt gtg agg aac cag ggc aac ttt tct gtg gtt ggt act gtt ctt      751
 Phe Gly Val Arg Asn Gln Gly Asn Phe Ser Val Val Gly Thr Val Leu
         180                 185                 190

 gct gcc acg cag gcg gag aag gcc gtg gca aac ttt gac agg acg gag      799
 Ala Ala Thr Gln Ala Glu Lys Ala Val Ala Asn Phe Asp Arg Thr Glu
     195                 200                 205

 tgg gtg cag atc cga aga cta gaa gct gca ggg gag agc tta gag gag      847
 Trp Val Gln Ile Arg Arg Leu Glu Ala Ala Gly Glu Ser Leu Glu Glu
 210                 215                 220                 225

 gaa atc cga aga aag cag att ctc ctg agg gga aag ctg aag aag aca      895
 Glu Ile Arg Arg Lys Gln Ile Leu Leu Arg Gly Lys Leu Lys Lys Thr
                 230                 235                 240

 gag gag gaa ctc aga agg atc cag acg caa aag gaa cag gcc aag gaa      943
 Glu Glu Glu Leu Arg Arg Ile Gln Thr Gln Lys Glu Gln Ala Lys Glu
             245                 250                 255

 aat gaa aac gga gag cta cag aaa att ata ctc ccc agg agc aga gtt      991
 Asn Glu Asn Gly Glu Leu Gln Lys Ile Ile Leu Pro Arg Ser Arg Val
         260                 265                 270

 aaa ggt aat aaa agc aac acc atg tac aaa cct atc ttc tcc cca gaa     1039
 Lys Gly Asn Lys Ser Asn Thr Met Tyr Lys Pro Ile Phe Ser Pro Glu
     275                 280                 285

 ttt gag ttt gag gaa gaa ttt agt aga gac agg aga gag gat gaa act     1087
 Phe Glu Phe Glu Glu Glu Phe Ser Arg Asp Arg Arg Glu Asp Glu Thr
 290                 295                 300                 305

 tgg gga cgg tct caa caa aat tca ggt cca ttc cag ttc tct gat tat     1135
 Trp Gly Arg Ser Gln Gln Asn Ser Gly Pro Phe Gln Phe Ser Asp Tyr
                 310                 315                 320

 aga atc cag agg ctc aaa agg gaa agg ctg gta gca agc aat aat aaa     1183
 Arg Ile Gln Arg Leu Lys Arg Glu Arg Leu Val Ala Ser Asn Asn Lys
             325                 330                 335

 att cga gac cca gtc tca gag cca tcg gtg gag aaa ttc tcc ccg cct     1231
 Ile Arg Asp Pro Val Ser Glu Pro Ser Val Glu Lys Phe Ser Pro Pro
         340                 345                 350

 tca gaa aca cca gtc ggt gct ttg cag gga tcc gcc aga aat tcc agc     1279
 Ser Glu Thr Pro Val Gly Ala Leu Gln Gly Ser Ala Arg Asn Ser Ser
     355                 360                 365

 ctg tcc atg gca cca gac tcc tca ggt tcc agc ggc tcc att gaa gag     1327
 Leu Ser Met Ala Pro Asp Ser Ser Gly Ser Ser Gly Ser Ile Glu Glu
 370                 375                 380                 385

 cca cag ctg gag aat aaa tcc ttg ctc ttc tgt gag tgt gct tgg gtg     1375
 Pro Gln Leu Glu Asn Lys Ser Leu Leu Phe Cys Glu Cys Ala Trp Val
                 390                 395                 400

 ttg aac act tgg atg cat aag gtg gga gga gcc gtg ggg tcc tac ttg     1423
 Leu Asn Thr Trp Met His Lys Val Gly Gly Ala Val Gly Ser Tyr Leu
             405                 410                 415

 ttt tca gtc ctg tac ctc ctt acc ttc cac tat cgg gta ctt cca agc     1471
 Phe Ser Val Leu Tyr Leu Leu Thr Phe His Tyr Arg Val Leu Pro Ser
         420                 425                 430

 act gaa cct ctc agg ttc tgt tgg gaa agt ggc ttg cct ctc agc agt     1519
 Thr Glu Pro Leu Arg Phe Cys Trp Glu Ser Gly Leu Pro Leu Ser Ser
     435                 440                 445

 acc tcc ttt gca ggc cct tgg ttt gcc tca acg ctg gca agt cag tta     1567
 Thr Ser Phe Ala Gly Pro Trp Phe Ala Ser Thr Leu Ala Ser Gln Leu
 450                 455                 460                 465

 ctg ctg ttg ctc ctt tcc tgt tct ctt tga c cttgcagatt aaaacccttt     1618
 Leu Leu Leu Leu Leu Ser Cys Ser Leu 
                 470

 tcattttctt actgctattc tacaagagac tcaggaagaa gataggtgcc aacttgaatg   1678

 atcagtctcc cttttacatt acaggctgaa cctcctcaaa agagcaactg gagatag      1735




      <210> 143
      <211> 3241
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2802)

      <400> 143
  atg gag aag gaa tgt atg aat gga tgt gtt cag cgg aca aaa gct gca      48
  Met Glu Lys Glu Cys Met Asn Gly Cys Val Gln Arg Thr Lys Ala Ala
    1               5                  10                  15

 gtt gag ttc cca cag aag act tcc gca tta gct gtc tgc ttc tgt ttt       96
 Val Glu Phe Pro Gln Lys Thr Ser Ala Leu Ala Val Cys Phe Cys Phe
              20                  25                  30

 ctt cat cat gga ttt cgc acc acc ccc att ccg gcc tct cca ttg att      144
 Leu His His Gly Phe Arg Thr Thr Pro Ile Pro Ala Ser Pro Leu Ile
          35                  40                  45

 cct cga tca tcc cgc ccc cta cac cgc cca ctc ccg ggc atc ccc att      192
 Pro Arg Ser Ser Arg Pro Leu His Arg Pro Leu Pro Gly Ile Pro Ile
      50                  55                  60

 ggc tgc gtg ctt ctc cgg ctc tca att cgc tgt acg tca tcc gtg cat      240
 Gly Cys Val Leu Leu Arg Leu Ser Ile Arg Cys Thr Ser Ser Val His
  65                  70                  75                  80

 ggc tgc cca ttg gcc ctc tgc aat act tgt ctt cat ctc acc gcc tat      288
 Gly Cys Pro Leu Ala Leu Cys Asn Thr Cys Leu His Leu Thr Ala Tyr
                  85                  90                  95

 gcc ccc gtg agc cgt acc cct ccg cgc tgg cct tcc cat tgg ctg ccc      336
 Ala Pro Val Ser Arg Thr Pro Pro Arg Trp Pro Ser His Trp Leu Pro
             100                 105                 110

 gcc cct tca ggc cct gcc ccc gcc ggt ccc gcc gcc ggt gcc gtc ggt      384
 Ala Pro Ser Gly Pro Ala Pro Ala Gly Pro Ala Ala Gly Ala Val Gly
         115                 120                 125

 gcc gcc gcc gcc gcc gat atg gcg cgt acg gcc cct gtg gag ccc ccg      432
 Ala Ala Ala Ala Ala Asp Met Ala Arg Thr Ala Pro Val Glu Pro Pro
     130                 135                 140

 ctg cgg cat tcc gcg ccc ccc tcg ccg gcc gcg ggt gag ccc cgc acc      480
 Leu Arg His Ser Ala Pro Pro Ser Pro Ala Ala Gly Glu Pro Arg Thr
 145                 150                 155                 160

 tcg gtc gag gcg gcg gtg gcc ccg cgg agg gtg ctg ttc gcc gac gag      528
 Ser Val Glu Ala Ala Val Ala Pro Arg Arg Val Leu Phe Ala Asp Glu
                 165                 170                 175

 gcc ttg ggg ctg ccg ctg gcg cag ttg cgc cgc tac cgg ccg tgg ggc      576
 Ala Leu Gly Leu Pro Leu Ala Gln Leu Arg Arg Tyr Arg Pro Trp Gly
             180                 185                 190

 ggg ccc ggg gcg ggc aag atg gcg gcg gcg gcc ggg caa gat ggc ggc      624
 Gly Pro Gly Ala Gly Lys Met Ala Ala Ala Ala Gly Gln Asp Gly Gly
         195                 200                 205

 ggc ggc ggc ggg gcc gac gag gac gac gat ggc gag gat ggg gat gaa      672
 Gly Gly Gly Gly Ala Asp Glu Asp Asp Asp Gly Glu Asp Gly Asp Glu
     210                 215                 220

 ggg gag gag gaa gag gag gct tgc ccc gag ccc tca ccg ctg tgc ccc      720
 Gly Glu Glu Glu Glu Glu Ala Cys Pro Glu Pro Ser Pro Leu Cys Pro
 225                 230                 235                 240

 gtc ccc gct ggc ggg ggg ttt tac ctg gtc ccc aca ttt tcg ctg ccg      768
 Val Pro Ala Gly Gly Gly Phe Tyr Leu Val Pro Thr Phe Ser Leu Pro
                 245                 250                 255

 ccc gcg ccg ggc cgt ctg gag cgc ttg ggg cgc gtc atg gtg gag ctg      816
 Pro Ala Pro Gly Arg Leu Glu Arg Leu Gly Arg Val Met Val Glu Leu
             260                 265                 270

 gag gcg ctg ctg ccg cct ccc gga gcg gtc ccc ggg ggt gcc ggg gtg      864
 Glu Ala Leu Leu Pro Pro Pro Gly Ala Val Pro Gly Gly Ala Gly Val
         275                 280                 285

 tgg gtg cct ggg ggc cgc ccg ccg gtg ctg cgc ggg ttg gta cgc gtg      912
 Trp Val Pro Gly Gly Arg Pro Pro Val Leu Arg Gly Leu Val Arg Val
     290                 295                 300

 ctg aac cgc tcc ttc gag aag gcg gtg cac gtg cgg gcc tca cac gac      960
 Leu Asn Arg Ser Phe Glu Lys Ala Val His Val Arg Ala Ser His Asp
 305                 310                 315                 320

 ggc tgg gct tcc ttt tgc gac cac cca gcg cgc tac gtc ccg cgc agc     1008
 Gly Trp Ala Ser Phe Cys Asp His Pro Ala Arg Tyr Val Pro Arg Ser
                 325                 330                 335

 ccg ccg tgg gca gga gcg gga gga aca gga gca gga gat ccc atc ctg     1056
 Pro Pro Trp Ala Gly Ala Gly Gly Thr Gly Ala Gly Asp Pro Ile Leu
             340                 345                 350

 gat ccg ggg ctc ggc ctg ggt ccc ggc cag gca tcc gcc tcc tcg ccc     1104
 Asp Pro Gly Leu Gly Leu Gly Pro Gly Gln Ala Ser Ala Ser Ser Pro
         355                 360                 365

 gac gac ggc ggc cgc acc gac cgc ttt gcc ttc cag ctg ccc ttt gct     1152
 Asp Asp Gly Gly Arg Thr Asp Arg Phe Ala Phe Gln Leu Pro Phe Ala
     370                 375                 380

 gag ggc gcg ggc gat ggg gcg cgc ctc gac ttc gtg gtg cgc tat gag     1200
 Glu Gly Ala Gly Asp Gly Ala Arg Leu Asp Phe Val Val Arg Tyr Glu
 385                 390                 395                 400

 acc cct gag ggc act ttc tgg gcc aac aac cac ggc cgc aac tac aca     1248
 Thr Pro Glu Gly Thr Phe Trp Ala Asn Asn His Gly Arg Asn Tyr Thr
                 405                 410                 415

 gtc ctg ctc cgg atc gca ccc gct ccc aca ccc act gat gcc gaa ggg     1296
 Val Leu Leu Arg Ile Ala Pro Ala Pro Thr Pro Thr Asp Ala Glu Gly
             420                 425                 430

 ctg ccc cag cag cag cag ctg ccg cag ctg gag cca cag ccc gag tgc     1344
 Leu Pro Gln Gln Gln Gln Leu Pro Gln Leu Glu Pro Gln Pro Glu Cys
         435                 440                 445

 cag ggt ccc gtg gag gct gag gcc agg cag ctg aag agc tgc atg aag     1392
 Gln Gly Pro Val Glu Ala Glu Ala Arg Gln Leu Lys Ser Cys Met Lys
     450                 455                 460

 ccg gtg agg cgc agg cct gcc gag gag gaa ctg aag acg aag aac atg     1440
 Pro Val Arg Arg Arg Pro Ala Glu Glu Glu Leu Lys Thr Lys Asn Met
 465                 470                 475                 480

 gat gat aac acc ttt gcc atg gca gag cat cct gat gtc cag gag tca     1488
 Asp Asp Asn Thr Phe Ala Met Ala Glu His Pro Asp Val Gln Glu Ser
                 485                 490                 495

 gtg ggt cca ctg gta gcc ccc acc cct ctc cgt cca tgg ccc cag atg     1536
 Val Gly Pro Leu Val Ala Pro Thr Pro Leu Arg Pro Trp Pro Gln Met
             500                 505                 510

 aca ctt cag gtt tct gac gtt ccg atg act ggc aac ccc gca gaa gaa     1584
 Thr Leu Gln Val Ser Asp Val Pro Met Thr Gly Asn Pro Ala Glu Glu
         515                 520                 525

 ggt gat gtc ccc aga agc agt cca cct gtg gct ttt aca gag gtc ctc     1632
 Gly Asp Val Pro Arg Ser Ser Pro Pro Val Ala Phe Thr Glu Val Leu
     530                 535                 540

 cag gca ccg gcc atc agg att ccc ccc tcc tcc cct ctc tgt ggc ctg     1680
 Gln Ala Pro Ala Ile Arg Ile Pro Pro Ser Ser Pro Leu Cys Gly Leu
 545                 550                 555                 560

 ggt ggc tcc ccc aga gac cag gcc tca ggg ccc gat gcg agc gag ggg     1728
 Gly Gly Ser Pro Arg Asp Gln Ala Ser Gly Pro Asp Ala Ser Glu Gly
                 565                 570                 575

 gcc acc ggg cct ttc ctg gag ccc agt cag cag cag gca gag gcc aca     1776
 Ala Thr Gly Pro Phe Leu Glu Pro Ser Gln Gln Gln Ala Glu Ala Thr
             580                 585                 590

 tgg gga gta tcg agt gag aat gga ggg ggg ctg gag gct gtg agt ggg     1824
 Trp Gly Val Ser Ser Glu Asn Gly Gly Gly Leu Glu Ala Val Ser Gly
         595                 600                 605

 tca gag gag ctg ctc ggt gag gac acc atc gac cag gag ctg gag cag     1872
 Ser Glu Glu Leu Leu Gly Glu Asp Thr Ile Asp Gln Glu Leu Glu Gln
     610                 615                 620

 ctc tac ctg tct cac ctg agc cgc cta cgg gct gct gtg gct gcg ggt     1920
 Leu Tyr Leu Ser His Leu Ser Arg Leu Arg Ala Ala Val Ala Ala Gly
 625                 630                 635                 640

 ggg gca ggg ggt ggt ggg gag ggc tcc aca gat gga ggg atg tcc ccc     1968
 Gly Ala Gly Gly Gly Gly Glu Gly Ser Thr Asp Gly Gly Met Ser Pro
                 645                 650                 655

 agc cat ccc ctg ggc ata ctg acg gac cgc gac ctg atc ttg aag tgg     2016
 Ser His Pro Leu Gly Ile Leu Thr Asp Arg Asp Leu Ile Leu Lys Trp
             660                 665                 670

 cct ggc cct gag cgg gcc ctg aac agc gcc ctg gct gag gag atc acg     2064
 Pro Gly Pro Glu Arg Ala Leu Asn Ser Ala Leu Ala Glu Glu Ile Thr
         675                 680                 685

 ctg cac tat gcc cgg ctg ggg cgt ggc gtg gag ctc atc aag gac acc     2112
 Leu His Tyr Ala Arg Leu Gly Arg Gly Val Glu Leu Ile Lys Asp Thr
     690                 695                 700

 gaa gac cct gat gat gaa ggg gag ggt gaa gag ggg ctc tct gtc aca     2160
 Glu Asp Pro Asp Asp Glu Gly Glu Gly Glu Glu Gly Leu Ser Val Thr
 705                 710                 715                 720

 ccc tcc agc cca gaa ggg gac agc ccc aag gaa tcg cct cca gaa atc     2208
 Pro Ser Ser Pro Glu Gly Asp Ser Pro Lys Glu Ser Pro Pro Glu Ile
                 725                 730                 735

 ctc tcc ggg gcc cgt tct gtg gta gcc acg atg gga gat gtg tgg ctc     2256
 Leu Ser Gly Ala Arg Ser Val Val Ala Thr Met Gly Asp Val Trp Leu
             740                 745                 750

 cca tgg gca gag ggc tca gga tgt gac ggc cct gtg gtt ctg ggt aca     2304
 Pro Trp Ala Glu Gly Ser Gly Cys Asp Gly Pro Val Val Leu Gly Thr
         755                 760                 765

 gag ggt cag ttc att ggg gat cct gag aaa ggg atg ggc aag gac acc     2352
 Glu Gly Gln Phe Ile Gly Asp Pro Glu Lys Gly Met Gly Lys Asp Thr
     770                 775                 780

 agc tct ttg cac atg aat agg gtg ata gct ggg gtg act gag tcc ctg     2400
 Ser Ser Leu His Met Asn Arg Val Ile Ala Gly Val Thr Glu Ser Leu
 785                 790                 795                 800

 ggg gag gcc ggg aca gaa gcc cag ata gag gtc acc agt gag tgg gca     2448
 Gly Glu Ala Gly Thr Glu Ala Gln Ile Glu Val Thr Ser Glu Trp Ala
                 805                 810                 815

 ggc agc ttg gat ccc ata tct ggc aag gag cca gcc tct ccc gtc ctt     2496
 Gly Ser Leu Asp Pro Ile Ser Gly Lys Glu Pro Ala Ser Pro Val Leu
             820                 825                 830

 ctg cag ggg caa aat ccc acc ctc ctc agt ccc ttg ggg gcc gaa gtc     2544
 Leu Gln Gly Gln Asn Pro Thr Leu Leu Ser Pro Leu Gly Ala Glu Val
         835                 840                 845

 tgt ctc tct agt gta gcc agg cct cat gtg agc tcc cag gat gaa aag     2592
 Cys Leu Ser Ser Val Ala Arg Pro His Val Ser Ser Gln Asp Glu Lys
     850                 855                 860

 gat gca ggc cca agc ctt gaa ccc cca aag aag tct ccc acc cta gca     2640
 Asp Ala Gly Pro Ser Leu Glu Pro Pro Lys Lys Ser Pro Thr Leu Ala
 865                 870                 875                 880

 gtc cct gca gaa tgt gtg tgt gca ctg cct cct cag ctc cgg ggg ccc     2688
 Val Pro Ala Glu Cys Val Cys Ala Leu Pro Pro Gln Leu Arg Gly Pro
                 885                 890                 895

 ttg acc cag act ctg ggg gtc ctg gcc ggg cta gtg gtg gtc cct gtg     2736
 Leu Thr Gln Thr Leu Gly Val Leu Ala Gly Leu Val Val Val Pro Val
             900                 905                 910

 gct ctg aac agc ggt gtg tcc ctc ctg gtg ctt gcg ctg tgc ctc tct     2784
 Ala Leu Asn Ser Gly Val Ser Leu Leu Val Leu Ala Leu Cys Leu Ser
         915                 920                 925

 ctg gct tgg ttc tca tag gctctg cttgtgggat cagcagaggc ttaagatggg     2838
 Leu Ala Trp Phe Ser 
     930

 atacatggcc tgtgcagtga ggggacctgg gtcctttgct tctgagaatg ctcaactgaa   2898

 agagaggcct tctcatcccc aagctctcca gtcaacacag ggctccctgt ggtgacacca   2958

 gtggagatga gggaacgggt agatggtgtg agtgagggga acttttagag tggaactggg   3018

 catgtcctcc gcctaccccc cgagcctgta tttatttttg tataattctc tggatgaggg   3078

 agagtggtcg tgagctggtc ttggggcaca attacccaga gatatattta ttaacagcca   3138

 acctgtgcaa cctgctggag ctttattttt aatttaattt atatagagta cctattatta   3198

 tatgccacaa tagagctcta tgagaaacag aaaaaaaaaa aaa                     3241




      <210> 144
      <211> 2278
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1011)..(1421)

      <400> 144
 cgaacattgc tcagccaggc tgttgagttt ctgatgcagg ccacccaggt tctgcaggaa     60

 aggatagatt tgggagagct gaggcgggaa gcacctgggc taagggagaa gcggaaggag    120

 ctggtgaccc tgtacaggag aagtgcaccc tagggccttc tgggccagag gcaccatccc    180

 ttctggccat ccatcaagtc catcaaggcc cagccctgct gagaaatgtg cttctgcttc    240

 tacagcaatg gctgcaggag ggccattggg catgtcaggg tttggccatg acccgaagag    300

 actcctggcg tccttcctac tctgctctgg ccagtggtgc caggtgccac ccagggctac    360

 tgcctggcta tctggcctgg cctctgggct ggggctgggg ctgggagcac acacgctggg    420

 acctatgtgt ttgtgtggtc gttccaaact gccccagggc tttgggggcg gcacttgggg    480

 tttctgggaa tgacatcatc tctgttcccc atccccagta gtttacattc ctgacttctg    540

 aatacagcac agctgagccc cctgcagctc ccatctccag ctattcctag gcaaagagcc    600

 tcatggctaa ggcagcctca aagccagccc ctcctcccac ctattctgag tagctgcaga    660

 ggccttgggt ccaggctcta ggttcatccc tcagttgggg ggaacgtagg acccagctgg    720

 agcctcttga gggagatgag aggcctcttt gtgaggagga cattagctgt gtggcctctc    780

 tctctttggc cctgtttcct tttttgcaaa acaaggacat tttctgcagc cccttcctct    840

 cagtgagcta tgattggagg gcttaggtct ggaggattca agagtggaag aggaatttaa    900

 ggggtcccct agtctagtct ctgcccctgg atagtgtcca gccttgtata tttctgaaga    960

 ggtggatccc agagtggctc tgatgtccac attagaaaaa cttacttgta   atg atc    1016
                                                          Met Ile
                                                            1

 atg tca gcc ttc aga aga gaa tcc cca cca act tct gtg cct cct cag     1064
 Met Ser Ala Phe Arg Arg Glu Ser Pro Pro Thr Ser Val Pro Pro Gln
           5                  10                  15

 atg ggg att tat ctg gat ctc tgt ggt tcc ttc tca gcc gaa aca ggt     1112
 Met Gly Ile Tyr Leu Asp Leu Cys Gly Ser Phe Ser Ala Glu Thr Gly
      20                  25                  30

 cca gta tcc cag tca ttt ctt caa atg ctg ata ggg gta tgt tgg aat     1160
 Pro Val Ser Gln Ser Phe Leu Gln Met Leu Ile Gly Val Cys Trp Asn
  35                  40                  45                  50

 ccg aag cca ctt ccc cgc ctt caa gcc cca gat ggg ctg ctc tcc tgt     1208
 Pro Lys Pro Leu Pro Arg Leu Gln Ala Pro Asp Gly Leu Leu Ser Cys
                  55                  60                  65

 aac ttt cta gga gaa gag aca ttt tct tct ttc cct ttc ctg gtc cat     1256
 Asn Phe Leu Gly Glu Glu Thr Phe Ser Ser Phe Pro Phe Leu Val His
              70                  75                  80

 ccc tgc acc ctg gtc ctc tcc cag cct ctc ccc cac att gtc cct gac     1304
 Pro Cys Thr Leu Val Leu Ser Gln Pro Leu Pro His Ile Val Pro Asp
          85                  90                  95

 tct agg ggc aca tcc agt ctc cat cgt gct gca gca gct gga ctg agg     1352
 Ser Arg Gly Thr Ser Ser Leu His Arg Ala Ala Ala Ala Gly Leu Arg
     100                 105                 110

 gca gag cct gta ggt gca gag gcc ctg gct ccc gag gtc cag cca ctc     1400
 Ala Glu Pro Val Gly Ala Glu Ala Leu Ala Pro Glu Val Gln Pro Leu
 115                 120                 125                 130

 tcc ctg ggg cct ctg ggg tga ga gcagcttccg ataggacctg cccagatttc     1453
 Ser Leu Gly Pro Leu Gly 
                 135

 tgcatgtgca cttttgttta ctgaaagaga gaaagggggg ggtcacagca acatgccctg   1513

 gcctttctgc cctgttcccc aaccccactg aggcctgctg cacaggtcaa tgccttcgtt   1573

 atcgttattg tactgtcact ttgttcttga ggtagtagtc aaggatcagg aggggcagat   1633

 gtcttctctg ggctgcgtgg ggccggagca gaggtgagca gcaatgcact ggttcgggag   1693

 cccccatcag cctccttgtg caaactgggc ccccatgcca cagtctggct ttccctccat   1753

 ctgccccagg acaagagcaa gaaggacatc agttgcccag tcatgtgatc ccctgccatc   1813

 ttgccttagg aacagccttc ccccaccagc agccatggct ggctggggct ttagccaagc   1873

 cacctactgc caggaattgg agcctcagtt ccctcctgtg tcaagtagct aactgcagca   1933

 gctggactga gggcagagtc tgtgggtgca gagaccctgc atgtaggtca caggttgagg   1993

 cccagccact ctccctgggg cctggtgggt aggcaagtag ctctggggcc acctcaagtg   2053

 accaaatgct attaatttcc atcctttagc aggctgggcc ctaggcagga agctggcttc   2113

 tgggagagga gtgagaacgt gcagggcctg cctagcttgc gtgcttgagg aaggtggcat   2173

 tccgtgcttg cctccttgag gagggtggca ttctgtgtct tctgcttatg aagcgccttt   2233

 cttaaagttt ggcaataaat ccatttttat ggaaaaaaaa aaaaa                   2278




      <210> 145
      <211> 1004
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (20)..(697)

      <400> 145
 gtaagagaag actggaagc atg tcg gag ttt tgg tta att tct gcc cct ggc      52
                      Met Ser Glu Phe Trp Leu Ile Ser Ala Pro Gly
                        1               5                  10

 gat aag gaa aat ttg caa gct ctg gag agg atg aat act gta acc tcc      100
 Asp Lys Glu Asn Leu Gln Ala Leu Glu Arg Met Asn Thr Val Thr Ser
              15                  20                  25

 aag tcc aac ctg tct tat aat acc aaa ttc gct att cct gac ttc aag      148
 Lys Ser Asn Leu Ser Tyr Asn Thr Lys Phe Ala Ile Pro Asp Phe Lys
          30                  35                  40

 gtg ggg acc ttg gat tcc ctg gtt ggc ctc tct gat gag ttg ggg aaa      196
 Val Gly Thr Leu Asp Ser Leu Val Gly Leu Ser Asp Glu Leu Gly Lys
      45                  50                  55

 ctc gac acc ttt gct gaa agc ctc ata agg aga atg gct cag agc gtg      244
 Leu Asp Thr Phe Ala Glu Ser Leu Ile Arg Arg Met Ala Gln Ser Val
  60                  65                  70                  75

 gtg gaa gtc atg gag gac tca aag ggg aag gtc cag gag cac ctc ctg      292
 Val Glu Val Met Glu Asp Ser Lys Gly Lys Val Gln Glu His Leu Leu
                  80                  85                  90

 gca aac gga gtt gac tta aca tcc ttt gtg acc cac ttt gaa tgg gac      340
 Ala Asn Gly Val Asp Leu Thr Ser Phe Val Thr His Phe Glu Trp Asp
              95                 100                 105

 atg gcc aaa tat cct gtc aag cag ccg ctc gtg agt gtg gtg gac aca      388
 Met Ala Lys Tyr Pro Val Lys Gln Pro Leu Val Ser Val Val Asp Thr
         110                 115                 120

 ata gcc aag caa ctg gcg cag atc gag atg gac ctg aag tcc cga acg      436
 Ile Ala Lys Gln Leu Ala Gln Ile Glu Met Asp Leu Lys Ser Arg Thr
     125                 130                 135

 gcc gcc tac aac act ctg aag aca aac ctg gag aac ctg gaa aag aaa      484
 Ala Ala Tyr Asn Thr Leu Lys Thr Asn Leu Glu Asn Leu Glu Lys Lys
 140                 145                 150                 155

 tcc atg ggg aac ctc ttc acc cgg aca ctg agt gat att gtg agc aaa      532
 Ser Met Gly Asn Leu Phe Thr Arg Thr Leu Ser Asp Ile Val Ser Lys
                 160                 165                 170

 gag gac ttc gtg ctg gat tct gaa tat ctc gtc aca ctt ctg gtc atc      580
 Glu Asp Phe Val Leu Asp Ser Glu Tyr Leu Val Thr Leu Leu Val Ile
             175                 180                 185

 gtc ccc aaa cca aac tac tca caa tgg caa aaa acc tac gaa tct ctc      628
 Val Pro Lys Pro Asn Tyr Ser Gln Trp Gln Lys Thr Tyr Glu Ser Leu
         190                 195                 200

 tca gac atg gtg gtc cct cga tca acc aaa ctc att act gag gac agg      676
 Ser Asp Met Val Val Pro Arg Ser Thr Lys Leu Ile Thr Glu Asp Arg
     205                 210                 215

 aaa ggg ggg ctt tca ctg tga at ctgtttcgaa agtgatgaag atttcaaaga      729
 Lys Gly Gly Leu Ser Leu 
 220                 225

 caggcaaaga aacaagttcc ctgtcgtgat tactatgttg ggcaggatga cggaggggga    789

 gtggcagatg gggtggtaga agacaggtgg cccgcgcgcg gttaggggac tcaatgaagc    849

 tcatggcggt cactcagccg agggtgggtc cgccagtggc acagggacag aggctgggca    909

 taaaccccag ttaagggacg tcgcgggagc caagggggga cggaaaatca gatcaacaag    969

 gaacggagaa aaaacacgcg cgttctctgt tctag                              1004




      <210> 146
      <211> 1001
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (540)..(803)

      <400> 146
 gggccttctc cataggaaga ggaggcgagt cccctggcca tatttaaacc acagttctcc     60

 acgccacctg tgcgactcgg gatccaacct ccccgcacca gccccagtcc aggtacctgg    120

 aacttagtcc gatcggtaac cggcgactac gtggggtaca ggtacccgag cgcgccccct    180

 ctgcggcccc gaagctgggc ggcgtgcgcg cccccgcgcc gcgccgagcc gggcgctcgg    240

 aaaggcgtcc ccgcggtgcc tgacagttcc ttcctcagcg cctgccccgt gagtgacgag    300

 gagcgcggag tctcgccata tcaggagggc cctgttacgt gaggctgtgc accgagacta    360

 ttccaggaag aagaggggac acttggtggg cggggtgatt tcgggcagtc aggtgggcga    420

 cccgcgtagg cgtctgaaag gcccgcgtcg ttagggaggg caggagtggc gtctctggtt    480

 acggggtcgg gcaaagggca gaggtcaccg tccaggttgg acagcagcac ctttgagcg     539                                                                 
 atg gcg gcg tct ggg gaa ccc cag agg cag tgg caa gag gag gtg gcg      587
 Met Ala Ala Ser Gly Glu Pro Gln Arg Gln Trp Gln Glu Glu Val Ala
   1               5                  10                  15

 gcg gtg gta gtg gtg ggc tcc tgc atg acc gac ctg gtc agg tta gtc      635
 Ala Val Val Val Val Gly Ser Cys Met Thr Asp Leu Val Arg Leu Val
              20                  25                  30

 cgg ggc cag tta ctc agt ctg cgg ctc ggg gga gga ggc gtg ccg tgc      683
 Arg Gly Gln Leu Leu Ser Leu Arg Leu Gly Gly Gly Gly Val Pro Cys
          35                  40                  45

 gct atg cgc cca gtg gag ctt ttg ggc gct ggg tct cca ggg ata gac      731
 Ala Met Arg Pro Val Glu Leu Leu Gly Ala Gly Ser Pro Gly Ile Asp
      50                  55                  60

 agt gct agc ttt ggg tat gag ctg cag gtt ttc gaa gcc ttc agc cta      779
 Ser Ala Ser Phe Gly Tyr Glu Leu Gln Val Phe Glu Ala Phe Ser Leu
  65                  70                  75                  80

 cct tcc tgg cat gaa aga act tga gtatataaag gtaaatctca ggggagggga     833
 Pro Ser Trp His Glu Arg Thr 
                  85

 cgtaataggc cagggtttag tgaaagctct aatattactc aaagcgctcc ccaaagacct    893

 gccctccaaa gacttgcgcc cccaaagacc tttcttggcc cggctgctga gcctttcccc    953

 aaacgagcca gggaactttg cccacgtcat tttacctccg agaatgtg                1001




      <210> 147
      <211> 1255
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (170)..(724)

      <400> 147
 tcaggtgaga ggagtctggt ccacatgacg atatcctcta accttgctgc tctccactgt     60

 tgtcaacatg ctaatcctgg catgcatcat catgctctgg caattgctgc tgacatccat    120

 gatctttgtg gcctgtgacc aagaagttca cagcagccgg cctgccgcc    atg gcc     175
                                                          Met Ala
                                                            1

 gac cac ctg atg ctc gcc gag ggc tac cgc ctg gtg cag agg ccg ccg      223
 Asp His Leu Met Leu Ala Glu Gly Tyr Arg Leu Val Gln Arg Pro Pro
           5                  10                  15

 tcc gcc gcg gcc gcc cat ggc cct cat gcg ctc cgg act ctg ccg ccg      271
 Ser Ala Ala Ala Ala His Gly Pro His Ala Leu Arg Thr Leu Pro Pro
      20                  25                  30

 tac gcg ggc ccg ggc ctg gac agt ggg ctg agg ccg cgg ggg gct ccg      319
 Tyr Ala Gly Pro Gly Leu Asp Ser Gly Leu Arg Pro Arg Gly Ala Pro
  35                  40                  45                  50

 ctg ggg ccg ccg ccg ccc cgc caa ccc ggg gcc ctg gcg tac ggg gcc      367
 Leu Gly Pro Pro Pro Pro Arg Gln Pro Gly Ala Leu Ala Tyr Gly Ala
                  55                  60                  65

 ttc ggg ccg ccg tcc tcc ttc cag ccc ttt ccg gcc gtg cct ccg ccg      415
 Phe Gly Pro Pro Ser Ser Phe Gln Pro Phe Pro Ala Val Pro Pro Pro
              70                  75                  80

 gcc gcg ggc atc gcg cac ctg cag cct gtg gcg acg ccg tac ccc ggc      463
 Ala Ala Gly Ile Ala His Leu Gln Pro Val Ala Thr Pro Tyr Pro Gly
          85                  90                  95

 cgc gcg gcc gcg ccc ccc aac gct ccg gga ggc ccc ccg ggc ccg cag      511
 Arg Ala Ala Ala Pro Pro Asn Ala Pro Gly Gly Pro Pro Gly Pro Gln
     100                 105                 110

 ccg gcg cca agc gcc gca gcc ccg ccg ccg ccc gcg cac gcc ctg ggc      559
 Pro Ala Pro Ser Ala Ala Ala Pro Pro Pro Pro Ala His Ala Leu Gly
 115                 120                 125                 130

 ggc atg gac gcc gaa ctc atc gac gag gag gcg ctg acg tcg ctg gag      607
 Gly Met Asp Ala Glu Leu Ile Asp Glu Glu Ala Leu Thr Ser Leu Glu
                 135                 140                 145

 ctg gag ctc ggg ctg cac cgc gtg cgc gag ctg ccc gag ctc ttc ctg      655
 Leu Glu Leu Gly Leu His Arg Val Arg Glu Leu Pro Glu Leu Phe Leu
             150                 155                 160

 ggc cag agc gag ttc gac tgc ttc tcg gac ttg ggg tcc gcg ccg ccc      703
 Gly Gln Ser Glu Phe Asp Cys Phe Ser Asp Leu Gly Ser Ala Pro Pro
         165                 170                 175

 gcc ggc tcc gtg agc tgc tga gg gcggccggcg cccgcccggc gtgccggaga      756
 Ala Gly Ser Val Ser Cys 
     180

 ggagaaaggg cccgactgcc cgccggaccc tgcacccagc gactgggccc cgcgcgcgcc    816

 ctccgcgagg gtggaggcgg cggctgtgtg cgcagggccc ggcaccggac tgggaccctg    876

 gcgtccctcc aggccttgcc tcctgcggga ggacagtttg gcttcacttc tctgacccca    936

 gcctcggccg taaagtgaaa gagaccggac cagcttcagc tttcggactc tggttcttgg    996

 atcgtgtcct ctccccctcg ccgccctctt cccccaatct gagccattgc aggcctctgc   1056

 ctgctgcccc ctctctcctc gggatcgggt ccccagagcc accatctcct gagcctccca   1116

 ccccgctgcc tgggccctgt ggttgctggg cctcccacct caaggagggg aaggttgtac   1176

 agcccgaacc cgtggagcaa tgccctgtct ggcctccaaa accaaaataa aactgggtca   1236

 ctttacaaaa aaaaaaaaa                                                1255




      <210> 148
      <211> 821
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (472)..(732)

      <400> 148
 tttcgtagag agtgcctact tctacagatt tctccccttc tactataggc aaaaatggta     60

 acaacattag tgtatgtaat agaaacatgc ttacactaca cataggaatg gcaaaccttc    120

 ctctgggcat ggacatttgc agcatttgca gtaataatgt aacaacagaa caattataac    180

 taggcttata aattttatct acatttactt atctagagat ggtcctctta gcttcggctg    240

 tgtgtagact agtcagcttc caggatgtga ctagagcaga gcttgcaaga tcttcaagct    300

 tcagccatgt gtagactgac cagcctccag tgtggtcaga gcagggcagt tgtccttctt    360

 actggtggtt gggattcgcc gtaggtctat tcgggtgggg caatcagggt cttgttggtt    420

 aatccactgg tcatagtcgg gagtcactgc tgctgctagt ttcagccagc t atg gtg     477
                                                          Met Val
                                                            1

 aat cca agg tgt gac acc tgc aac gcg gtt cct gaa gtg ctg gtg tca      525
 Asn Pro Arg Cys Asp Thr Cys Asn Ala Val Pro Glu Val Leu Val Ser
           5                  10                  15

 tcc tgc agc ccc atc tca ggt tca gtt gca ctg ctg ggc agg atg cgg      573
 Ser Cys Ser Pro Ile Ser Gly Ser Val Ala Leu Leu Gly Arg Met Arg
      20                  25                  30

 gga gag cca gtc tcc atc cgg gtg aaa ctc ccc cat ggc atg cct tgg      621
 Gly Glu Pro Val Ser Ile Arg Val Lys Leu Pro His Gly Met Pro Trp
  35                  40                  45                  50

 atg cca ggt ctt cca cag ccc cag ggc cct agt ccc atg ggc aaa gga      669
 Met Pro Gly Leu Pro Gln Pro Gln Gly Pro Ser Pro Met Gly Lys Gly
                  55                  60                  65

 gac agt aaa tct gtt atc tcc aat ccc cat atg ggc cac cag aaa tgt      717
 Asp Ser Lys Ser Val Ile Ser Asn Pro His Met Gly His Gln Lys Cys
              70                  75                  80

 ttg ggg atg att tag gaatcagaga gaccgatggg gttgaggagg atatatgtat      772
 Leu Gly Met Ile 
          85

 tatttaggtg caccagccaa cccagtcaga tgaattccac cacacggta                821




      <210> 149
      <211> 1883
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (174)..(1031)

      <400> 149
 tttcgtccaa ggtaggaaag cccatcccat atggatgaag gtgagcttga tcacctccca     60

 gggaccaacc actcatccaa cccagagtgg ctgggggtgg caggagtggc ccgccaattt    120

 ggatgaacct cgtgtccccc taacaaagtg aaagtggttc actggtggag aaa   atg     176
                                                              Met
                                                                1

 ggc cga tac agc ggc aag tgc agc aag gaa gag ttt gct ggc aga atg      224
 Gly Arg Tyr Ser Gly Lys Cys Ser Lys Glu Glu Phe Ala Gly Arg Met
               5                  10                  15

 ttt att gta gaa cgt tca cag ctc aca ccc aga gaa acc agc tgc gct      272
 Phe Ile Val Glu Arg Ser Gln Leu Thr Pro Arg Glu Thr Ser Cys Ala
          20                  25                  30

 ggc ggc tac gga gtt aaa gtt aaa aaa tgg aat cca acc act cta gga      320
 Gly Gly Tyr Gly Val Lys Val Lys Lys Trp Asn Pro Thr Thr Leu Gly
      35                  40                  45

 ccc ata cag gat agg cct cat att gta atc atg tct act tct act gct      368
 Pro Ile Gln Asp Arg Pro His Ile Val Ile Met Ser Thr Ser Thr Ala
  50                  55                  60                  65

 gtt aaa gtt gca ggt gtc aca cct tgg att cac cat agc tgg ctg aaa      416
 Val Lys Val Ala Gly Val Thr Pro Trp Ile His His Ser Trp Leu Lys
                  70                  75                  80

 cta gca gca gca gtg act ccc gac tat gac cag tgg att aac caa caa      464
 Leu Ala Ala Ala Val Thr Pro Asp Tyr Asp Gln Trp Ile Asn Gln Gln
              85                  90                  95

 gac cct gat tgc ccc acc cga ata gac cta cgg cga atc cca acc acc      512
 Asp Pro Asp Cys Pro Thr Arg Ile Asp Leu Arg Arg Ile Pro Thr Thr
         100                 105                 110

 agt aag aag gac aac tgc cct gct ctg acc aca ctg gag gct gct gaa      560
 Ser Lys Lys Asp Asn Cys Pro Ala Leu Thr Thr Leu Glu Ala Ala Glu
     115                 120                 125

 aac ata gct ggc agc tta gga att tcc tca tgc tat gta cgt gga gga      608
 Asn Ile Ala Gly Ser Leu Gly Ile Ser Ser Cys Tyr Val Arg Gly Gly
 130                 135                 140                 145

 act aat atg ggg aac cag tgg cca tgg gag gca aag gaa tta atg cca      656
 Thr Asn Met Gly Asn Gln Trp Pro Trp Glu Ala Lys Glu Leu Met Pro
                 150                 155                 160

 caa gat aac ttc act tcg ctt aac cct gcc agt gaa cca aca gcc tca      704
 Gln Asp Asn Phe Thr Ser Leu Asn Pro Ala Ser Glu Pro Thr Ala Ser
             165                 170                 175

 gcc agt gtt tgg ttg tta aaa acc tcc ata att gga aag tac cgt atc      752
 Ala Ser Val Trp Leu Leu Lys Thr Ser Ile Ile Gly Lys Tyr Arg Ile
         180                 185                 190

 gcc cgt tgg gga aag gct ttc aca gag gca gta gga gaa ata acc tgc      800
 Ala Arg Trp Gly Lys Ala Phe Thr Glu Ala Val Gly Glu Ile Thr Cys
     195                 200                 205

 cta ggg caa cag tat tat gat gag act aaa aac aaa act cta tgg aga      848
 Leu Gly Gln Gln Tyr Tyr Asp Glu Thr Lys Asn Lys Thr Leu Trp Arg
 210                 215                 220                 225

 agc acc cag aat tac tcc tac tta cca gat cca aat cct tta tct cca      896
 Ser Thr Gln Asn Tyr Ser Tyr Leu Pro Asp Pro Asn Pro Leu Ser Pro
                 230                 235                 240

 ttc tct acc cta agc cac act tgg cat caa cta gag gtt cca aat gct      944
 Phe Ser Thr Leu Ser His Thr Trp His Gln Leu Glu Val Pro Asn Ala
             245                 250                 255

 tcg aaa gca ccc tct ggc cta tat tgg atc tgt gga gca tgg gca tat      992
 Ser Lys Ala Pro Ser Gly Leu Tyr Trp Ile Cys Gly Ala Trp Ala Tyr
         260                 265                 270

 tgg caa ctg cca gct aaa tgg aca gga gca tgt gtg tag taacaatcaa      1041
 Trp Gln Leu Pro Ala Lys Trp Thr Gly Ala Cys Val 
     275                 280                 285

 gccattcttc tttctaattc ctctaaagca aggggaactc ttatggtatc cagttgatga   1101

 tgaaaataaa agaagaacta gaagagcata atcacaaaaa tagacacaaa tgtcaaaaag   1161

 gatgtggaca taggagactg gaaagataat gaatggcctc ctgaaagaat aattaaatat   1221

 tattggccag ctacctgggt gcaagatggg tcatggggtt accacacccc aatctatatg   1281

 ctcaactgca tcataaggtt gcaggcagtc tttgaaatta taaccaatga aacatcaagg   1341

 gcactagatt tattggcaat acaagcaaca caaatgagaa atgctatata ttgaaataga   1401

 ttggcattag attatcactt agcctctgaa ggaagagtat gtggaaaatt taatttaacc   1461

 aactgttgcc tagaaattgc taataatggc cgggttgtca tggaaatcag agctagaatg   1521

 cacaagttgg cccatgttcc aattcagact tggtcctaat ggtccctgga ttctttgttt   1581

 ggaggatggt tctcaacctt tggaggattc aaaaccctca ctggtgggtt tttgtttatt   1641

 cttggcatct gcctcatcct cccttacctt ttacccctgt ttattaggag gattcagtca   1701

 actatagagg cagtaataac tcaacacact accacacagt tgatggcatt aaccaaatat   1761

 cagccactgc cagtagaaga agctcagctc tgtgaagagg tggcaaatag tggtgctttc   1821

 tattaacacc tttgttataa aaagcaacaa aggggggaaa tggaacagga aaaaaaaaaa   1881

 aa                                                                  1883




      <210> 150
      <211> 1260
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (276)..(653)

      <400> 150
 gcgtggaatt cgaaaagggg tgtggaaagt gaacctcagc cgctgggaag tgggagccgg     60

 aggagggggc ggcggtcagt gccgggcggc ttcgggcgtc ccctatacca gagtggtcat    120

 ccccagctgt ggggacattg tacaagaaag ggttgtagga ggactgcgag gctgaagggt    180

 cacctcggtg aataacgaca acaggcttag gactcaggga aagaaacacc cgggagagga    240

 agttaaggac aattaagact ttggcagcct tcacg   atg gag aac ctg tat acc     293
                                          Met Glu Asn Leu Tyr Thr
                                            1               5

 ctc tta cct cta gat tct gaa agc aaa tta agg ggc gtt gaa tgg act      341
 Leu Leu Pro Leu Asp Ser Glu Ser Lys Leu Arg Gly Val Glu Trp Thr
              10                  15                  20

 ggt ttt caa gcg cag aat gta gca gtt ccc gat tcc ctt ttc ctt agt      389
 Gly Phe Gln Ala Gln Asn Val Ala Val Pro Asp Ser Leu Phe Leu Ser
          25                  30                  35

 tca ttg att ctc aaa cct tat aat aca tac aaa tca ctg agg agc ccg      437
 Ser Leu Ile Leu Lys Pro Tyr Asn Thr Tyr Lys Ser Leu Arg Ser Pro
      40                  45                  50

 tta aag ggc ata ttc tgg gtc tcc ctg tac ttc tct cca cct ccc aat      485
 Leu Lys Gly Ile Phe Trp Val Ser Leu Tyr Phe Ser Pro Pro Pro Asn
  55                  60                  65                  70

 tca gat tcc cca gat gtc tgc cat agg gcc ttt caa gct gga att cag      533
 Ser Asp Ser Pro Asp Val Cys His Arg Ala Phe Gln Ala Gly Ile Gln
                  75                  80                  85

 ctg ctg cgc tgt gct tcc tgg cat ttt gga gac aca cat ttt ggg aac      581
 Leu Leu Arg Cys Ala Ser Trp His Phe Gly Asp Thr His Phe Gly Asn
              90                  95                 100

 acc ccc atg ggt ttc agg ggc ttc ctg cgt ctg tgg aga aaa ctt ttc      629
 Thr Pro Met Gly Phe Arg Gly Phe Leu Arg Leu Trp Arg Lys Leu Phe
         105                 110                 115

 cct tgg gct tct ttg gct tct tag gattgtcctc aaaaagaagt tgaccttggg     683
 Pro Trp Ala Ser Leu Ala Ser 
     120                 125

 caatctactt aactttccct ggcttccatt tcttatctag tgaaataatt attataataa    743

 aacctcagtg ggtaattgtg aggatgaaat atagtcttgt atctgaaagc atattgtaga    803

 cttgtgcagt gttgactgtt attcttcagt agcagcaggg cggtgtggaa agctccagga    863

 cttggaatcc acctaagcct ttctttctgt aaatttagtg aaaataatac taaccttaaa    923

 tggttgtttt gaagattaag aaaactgaag taaatagtaa agtaaatgtt ggttcgttca    983

 tttagtcgac agtaacaata tttccattta ttctttctct aagttgatgt ttatacagtg   1043

 agttcaaact ttttattcag actttctgag tgatcggtgc agtccctaat tcatgggctg   1103

 ttttcctcca tgaactctgt gaagcattat tgctatttct tcttcacata aagaaatcaa   1163

 gattgaaaga agatttaaaa acttggcaca aggtcacaca actagtaaat attaggatca   1223

 gaataaaacc taggtctggg tcagctgtgg tggctga                            1260




      <210> 151
      <211> 959
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(669)

      <400> 151
  atg ggg gag cag agg gca gca ctt cct cca gct cca aaa gag tgc acc      48
  Met Gly Glu Gln Arg Ala Ala Leu Pro Pro Ala Pro Lys Glu Cys Thr
    1               5                  10                  15

 cac ccc aac gtt acc aat aca ctc gtg cag gcg gaa agc tcc gac gcc       96
 His Pro Asn Val Thr Asn Thr Leu Val Gln Ala Glu Ser Ser Asp Ala
              20                  25                  30

 ggt gtg cgt cta cgc tgg ggg cgt ggc ctg act gcg cgg cca gac gcc      144
 Gly Val Arg Leu Arg Trp Gly Arg Gly Leu Thr Ala Arg Pro Asp Ala
          35                  40                  45

 agc gcc atg gag gag tac gct cgg gag ccc tgc cca tgg cga att gtg      192
 Ser Ala Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val
      50                  55                  60

 gat gat tgc ggt gga gcc ttc act atg ggt gtc atc ggt ggc gga gtc      240
 Asp Asp Cys Gly Gly Ala Phe Thr Met Gly Val Ile Gly Gly Gly Val
  65                  70                  75                  80

 ttc cag gcc atc aag ggt ttc cgc aat gcc cct gtt gga att cgg cac      288
 Phe Gln Ala Ile Lys Gly Phe Arg Asn Ala Pro Val Gly Ile Arg His
                  85                  90                  95

 cgg ttg aga ggt agt gcc aat gct gtg agg atc cga gcc ccc cag att      336
 Arg Leu Arg Gly Ser Ala Asn Ala Val Arg Ile Arg Ala Pro Gln Ile
             100                 105                 110

 gga ggt agc ttc gca gtg tgg ggg ggc ctg ttc tcc acc att gac tgt      384
 Gly Gly Ser Phe Ala Val Trp Gly Gly Leu Phe Ser Thr Ile Asp Cys
         115                 120                 125

 ggc ctg gtg cgg ctt cgg ggc aag gag gat ccc tgg aac tct atc acc      432
 Gly Leu Val Arg Leu Arg Gly Lys Glu Asp Pro Trp Asn Ser Ile Thr
     130                 135                 140

 agt gga gca ttg acc ggg gct gtg ctg gct gcc cgc agt ggc cca ctg      480
 Ser Gly Ala Leu Thr Gly Ala Val Leu Ala Ala Arg Ser Gly Pro Leu
 145                 150                 155                 160

 gcc atg gtg ggc tca gca atg atg ggg ggc atc ctg ttg gcc ctc att      528
 Ala Met Val Gly Ser Ala Met Met Gly Gly Ile Leu Leu Ala Leu Ile
                 165                 170                 175

 gag ggc gtt ggc atc ctc ctc act cgc tac aca gcc cag cag ttc cga      576
 Glu Gly Val Gly Ile Leu Leu Thr Arg Tyr Thr Ala Gln Gln Phe Arg
             180                 185                 190

 aat gcg ccc cca ttc ctg gag gac ccc agc cag ctg ccc cct aag gat      624
 Asn Ala Pro Pro Phe Leu Glu Asp Pro Ser Gln Leu Pro Pro Lys Asp
         195                 200                 205

 ggc acc ccg gcc cca ggc tac ccc agc tat cag cag tac cac tga gga      672
 Gly Thr Pro Ala Pro Gly Tyr Pro Ser Tyr Gln Gln Tyr His 
     210                 215                 220

 agccactgcc accatgggag ctacttctcg gttccctccc cgatggtcta cctcgaaggg    732

 agggctggct cccagttagc cctgggaccc tccagagagg gtttctactc tgctccctag    792

 tcccagggtg ggggtggggc accccagctg ccctgacaga tgggtcccct ttttctctct    852

 cagggcaccc cagccccaca ctcacatgta cgaagttctc accccagctc ctttgtgtgg    912

 caccctgatg agtatttaaa gcccgttttg aaatgccaaa aaaaaaa                  959




      <210> 152
      <211> 1113
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(819)

      <400> 152
  atg ggg gag cag agg gca gca ctt cct cca gct cca aaa gag tgc acc      48
  Met Gly Glu Gln Arg Ala Ala Leu Pro Pro Ala Pro Lys Glu Cys Thr
    1               5                  10                  15

 cac ccc aac gtt acc aat aca ctc gtg cag gcg gaa agc tcc gac gcc       96
 His Pro Asn Val Thr Asn Thr Leu Val Gln Ala Glu Ser Ser Asp Ala
              20                  25                  30

 ggt gtg cgt cta cgc tgg ggg cgt ggc ctg act gcg cgg cca gac gcc      144
 Gly Val Arg Leu Arg Trp Gly Arg Gly Leu Thr Ala Arg Pro Asp Ala
          35                  40                  45

 agc gcc atg gag gag tac gct cgg gag ccc tgc cca tgg cga att gtg      192
 Ser Ala Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val
      50                  55                  60

 gat gat tgc ggt gga gcc ttc act atg ggt gtc atc ggt ggc gga gtc      240
 Asp Asp Cys Gly Gly Ala Phe Thr Met Gly Val Ile Gly Gly Gly Val
  65                  70                  75                  80

 ttc cag gcc atc aag ggt ttc cgc aat gcc cct gtt tgc aga ttg ctg      288
 Phe Gln Ala Ile Lys Gly Phe Arg Asn Ala Pro Val Cys Arg Leu Leu
                  85                  90                  95

 tct gaa gct ccc ttg ttt atc tac tct tgc tca aga tct gtg tct ccc      336
 Ser Glu Ala Pro Leu Phe Ile Tyr Ser Cys Ser Arg Ser Val Ser Pro
             100                 105                 110

 acc gtt aat gtg agc tct gag agg gca gag agc aga cct acc ttg ttc      384
 Thr Val Asn Val Ser Ser Glu Arg Ala Glu Ser Arg Pro Thr Leu Phe
         115                 120                 125

 atg gct gta tcc ctg cat atg gca tgg tgc ttg gca cat ata gga att      432
 Met Ala Val Ser Leu His Met Ala Trp Cys Leu Ala His Ile Gly Ile
     130                 135                 140

 cgg cac cgg ttg aga ggt agt gcc aat gct gtg agg atc cga gcc ccc      480
 Arg His Arg Leu Arg Gly Ser Ala Asn Ala Val Arg Ile Arg Ala Pro
 145                 150                 155                 160

 cag att gga ggt agc ttc gca gtg tgg ggg ggc ctg ttc tcc acc att      528
 Gln Ile Gly Gly Ser Phe Ala Val Trp Gly Gly Leu Phe Ser Thr Ile
                 165                 170                 175

 gac tgt ggc ctg gtg cgg ctt cgg ggc aag gag gat ccc tgg aac tct      576
 Asp Cys Gly Leu Val Arg Leu Arg Gly Lys Glu Asp Pro Trp Asn Ser
             180                 185                 190

 atc acc agt gga gca ttg acc ggg gct gtg ctg gct gcc cgc agt ggc      624
 Ile Thr Ser Gly Ala Leu Thr Gly Ala Val Leu Ala Ala Arg Ser Gly
         195                 200                 205

 cca ctg gcc atg gtg ggc tca gca atg atg ggg ggc atc ctg ttg gcc      672
 Pro Leu Ala Met Val Gly Ser Ala Met Met Gly Gly Ile Leu Leu Ala
     210                 215                 220

 ctc att gag ggc gtt ggc atc ctc ctc act cgc tac aca gcc cag cag      720
 Leu Ile Glu Gly Val Gly Ile Leu Leu Thr Arg Tyr Thr Ala Gln Gln
 225                 230                 235                 240

 ttc cga aat gcg ccc cca ttc ctg gag gac ccc agc cag ctg ccc cct      768
 Phe Arg Asn Ala Pro Pro Phe Leu Glu Asp Pro Ser Gln Leu Pro Pro
                 245                 250                 255

 aag gat ggc acc ccg gcc cca ggc tac ccc agc tat cag cag tac cac      816
 Lys Asp Gly Thr Pro Ala Pro Gly Tyr Pro Ser Tyr Gln Gln Tyr His
             260                 265                 270

 tga ggaa gccactgcca ccatgggagc tacttctcgg ttccctcccc gatggtctac      873
 


 ctcgaaggga gggctggctc ccagttagcc ctgggaccct ccagagaggg tttctactct    933

 gctccctagt cccagggtgg gggtggggca ccccagctgc cctgacagat gggtcccctt    993

 tttctctctc agggcacccc agccccacac tcacatgtac gaagttctca ccccagctcc   1053

 tttgtgtggc accctgatga gtatttaaag cccgttttga aatgccaaaa aaaaaaaaaa   1113




      <210> 153
      <211> 1135
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (109)..(501)

      <400> 153
 aggacgacgc ctgcgaagat ggccgctgcg tcctcatcgg attccgacgc ctgcggagct     60

 gagagcaatg aggccaattc gaagtggttg gatgcgcact acgaccca atg gcc aat     117
                                                      Met Ala Asn
                                                        1

 atc cac acc ttt tct gcc tgc cta gcg ctg gca gat tta cat ggg gat      165
 Ile His Thr Phe Ser Ala Cys Leu Ala Leu Ala Asp Leu His Gly Asp
       5                  10                  15

 ggg gaa tac aag ctg gtg gta ggg gac ctt ggc cct ggt ggg cag cag      213
 Gly Glu Tyr Lys Leu Val Val Gly Asp Leu Gly Pro Gly Gly Gln Gln
  20                  25                  30                  35

 ccc cgc ctg aag gtg ctc aaa gga cca ctg gtg atg acc gaa agc ccg      261
 Pro Arg Leu Lys Val Leu Lys Gly Pro Leu Val Met Thr Glu Ser Pro
                  40                  45                  50

 cta cct gct ctg cca gct gct gct gcc acc ttc ctc atg gag caa cat      309
 Leu Pro Ala Leu Pro Ala Ala Ala Ala Thr Phe Leu Met Glu Gln His
              55                  60                  65

 gag ccc cgg acc cca gct ctg gca ctt gct tca ggc cct tgt gtc tat      357
 Glu Pro Arg Thr Pro Ala Leu Ala Leu Ala Ser Gly Pro Cys Val Tyr
          70                  75                  80

 gtg tat aag aat ctc aga ccc tac ttc aag ttc agc cta ccc caa ttg      405
 Val Tyr Lys Asn Leu Arg Pro Tyr Phe Lys Phe Ser Leu Pro Gln Leu
      85                  90                  95

 cct cca aat cct ctg gaa caa gac ctt tgg aac cag gcc aaa gag gac      453
 Pro Pro Asn Pro Leu Glu Gln Asp Leu Trp Asn Gln Ala Lys Glu Asp
 100                 105                 110                 115

 cga atc gac ccc tta acc ctg aag gag atg ctg gag agc atc cgg tga      501
 Arg Ile Asp Pro Leu Thr Leu Lys Glu Met Leu Glu Ser Ile Arg 
                 120                 125                 130

 gaggctgcct tccccttcat acccccctca ctccttcatc ccatctgagc cccagggccc    561

 cattcttcca ttcggctgcc atgctggccc cctttccttg cagggagacg gcagaggagc    621

 ctttgtccat ccagtcactc aggtttctgc agctggagct aagtgaaatt ggaggcattt    681

 gtaaaccaaa cacaagtcca actccatcaa gcggcagaca gtcaatcacc acatgagcac    741

 ttgaagaaga acctgggctg acgaggatgc tgtgtcttgc ctggtgctgg gcaccgagaa    801

 caaggagcct ctggtgctgg accgaggctc aaccatttac cagatgagcg tcccaggtaa    861

 cgggttccag aggtctcggc ccatggacgt taatcccgct gccggcggcc gaagggaaac    921

 tgatttctga gagggtgcca tcgggccacg ggcgggcagg aactcgacac ggggataagg    981

 ccgagaagaa gacggctagg gcgatgtaca caaagcgtga caaaggcgtc ccaactagga   1041

 ctgggcttac atggcacaac gttgtctaca cacaaagaag gcggtcatca tgaggacaaa   1101

 gtctcctcct tgccgccacc ccctcgtcgt cgat                               1135




      <210> 154
      <211> 3340
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (635)..(838)

      <400> 154
 gacgggcacc aacgcctggg caacgagcgc caaactcttt ccccaaaacc acccacccca     60

 aaaagcccca ctccgtgata gtttgactag gctaaaaagt ggtgtaggtg tgaaagtctt    120

 ttttgtttat tttaatctgg ggtttgttga gcttcttgtt tctgtagatt aaagcctttc    180

 atcacccttt gggaagtttt tgacccttaa ttcttcaaat aattttactg tccccttact    240

 ccctttgaga ctttggatcc aaccaccacc aaaagaccgt atgtctgttc tttccccatt    300

 attctgtggt caaagcaatc ataatccaaa ttcttcgcca gttattttgt ggctagaaag    360

 tcagttttgg gggttttttt tttttttatt tgaagtgcca aattaacttt agtcagaatg    420

 tgagcagatg gctaagttct ctcctcccca gaatggatta acagctgcgt ggaaagtggg    480

 ggagagagtg gatggagact tttagagatg ttaaaactgc agtagaatga aatgagtcag    540

 ggagcttcag ttagaaaata aagttgaggc agtttttgtg aagataatat ggttagggct    600

 ggagtgcact agtctttttg cttattcatt ttgc    atg gtt tta aaa tta aaa     652
                                          Met Val Leu Lys Leu Lys
                                            1               5

 ata att ccg aag ata cac cag ctc aca aat gaa aac gtc agc ctc tgc      700
 Ile Ile Pro Lys Ile His Gln Leu Thr Asn Glu Asn Val Ser Leu Cys
              10                  15                  20

 ccc acc ctc cct cct gcc caa agt gaa ttt ggt act cag aaa aga act      748
 Pro Thr Leu Pro Pro Ala Gln Ser Glu Phe Gly Thr Gln Lys Arg Thr
          25                  30                  35

 gtt tat acc act cac ctt tct ccc agc atg tac tca ctg tgg gca gat      796
 Val Tyr Thr Thr His Leu Ser Pro Ser Met Tyr Ser Leu Trp Ala Asp
      40                  45                  50

 gca cca ata cat ggt aat cct ctt act cat ttt aag acg tag gaaactc      845
 Ala Pro Ile His Gly Asn Pro Leu Thr His Phe Lys Thr 
  55                  60                  65

 aatattcttc tctaaccata tacgataggg ctcttcgctt ttaatgatat ctgggatttc    905

 tgtggaactt ggcaaatttt cagagcacct tcactcacat aatgtcattt gaacctcaca    965

 atgttcttgg gatggagtca gttgttcagg gtccccgtgt gtgtgataag cagtgctggc   1025

 tggctgtctt cagaactctt ggaaatcttt acacatgcga gtgctaacca ctttgagcaa   1085

 cggctgcctt cttgtagatg acttgctgtt ctttatgaca gggatcagtg gcatttgttt   1145

 cctagcagta tttagcacct ttttgccacc ttggtgaaca gaaaattgta ttttcctgtc   1205

 tttcatggct gaaaacaaaa gtaatgggaa ttttaaatac gtttgcagaa actgcccctc   1265

 ccctcattga gggtcactgc tcaagagtgc aggagtggac tctccactga tgggtctccc   1325

 tccccatcct ggtttccacc ccgggctggc tagctctgtt ggtttgaaga ctgacagcca   1385

 gcctggctca ttctcattat tggctagtta gctttcttta tcaacctgct cactcacaaa   1445

 tgtgtgccct cagccagaga gtaagaaagc ccaaatctgt tacagcttct aaaaaaatag   1505

 atttctaatt tgtcctactc atgttaggag cattatcttt gaaggtaaaa catagtgtat   1565

 cattgtgtaa actcccaggc ttgatgtagc agaagagatc atttctggag gcttcagcaa   1625

 tggaatttag cattataaga gagattggac aaaccagtcc aaagtggtcc gagttcttaa   1685

 atccaggtag ggaactcact cttctttctt ctctggacct aattgggcat tgggctttag   1745

 tgagaccaca gaccaggccc gtctctcctg taggctttta attcaatggc aactctattt   1805

 caaagaataa aagcctttgg agagttgcgg cagttctggg ggcgggctca ggagagtcca   1865

 tagatcagcc gtaactggaa cgtagaatct acgtctgcct ctgaatggac ttcccacctc   1925

 ctctctcttg ctctgatgct tgcctctggg cctctccatg cccaaggtgg tctttcatcc   1985

 ttgacaggct ggtaatgtgc tggccacctc cagctcctgc atcgagtctg taaaccagag   2045

 ctggttctca tggccttcgt cacgatacca ggatacggag gggagcccag ggccatccat   2105

 acccacccca gggtaacggg gctggcctgg cattagtcat tatttagttt ccaggccaac   2165

 catccagata gagattccct ctttcctttg agcagtgctc tcaagagctc cgtgcctgtc   2225

 cacaatgacc tagagtgcat cctgctcatt gtcagtgtag cccctcgccc ctatattcat   2285

 ccaggatact tggaagtgct aaaataggaa gggattcggc tttcaacttt gctaccatct   2345

 tccctgaagc aggaaaatga acatggactt aaatgttctt tgaaaaaacc aaagttttaa   2405

 gatttgctgt gtgatgaagt gacagggagg gccggagtca gcaggtgcca gactttctgt   2465

 tctgtctgcc atgggtttgt ccagctcagg tagctctagg agcaccatcc tgccctagca   2525

 gagcccaggc cttgccctca tgaagcatca ttgaaatagc aggagcatgt tgatttcttg   2585

 gttaggttgc attataataa caagagtcag aacattaatt cgaaacaact tgcagtatgc   2645

 atttcttcac accagtacat tcttaagtgt acttgtttat aaggaataac ataaactaat   2705

 ctgtaccttt atatatatgt gtgtgtacat atatacatat ataaactgta tagtgtacat   2765

 ggtaatgatt tattgctatg ccccagatcc ttaatgtagt tctcatcctc cgcatgccct   2825

 cagccacaag cgggtgactg actgttccct gatgatttgg cccacctcct gtgtttggac   2885

 ctctagggag gagggttttg gtcatactct ccttatcctc gtgcacagaa atgctcaggg   2945

 tccccatgtg cctgttgttc agccctctct cttgttccct ttctgagcat gtggtccttc   3005

 cccaggctgt gggacagctg ccttcccacg aaagtgtaaa gcagtattaa gatcattact   3065

 gcatgtgccc taaaaaccca agttttctat tcccttagga cagaaaattg catgtgaggt   3125

 gggataatcg agtttcagtg acccacgtca gttacacatt aaagccagac cccatgataa   3185

 aattccacaa aatggaaata aaactcaaat ttctttagca ttgtgtaaat aaatctgaat   3245

 gtgtttaact ttgtactggt aattttctgt atatttggaa tatttgggtt aaaaataaaa   3305

 cagactggac tttgttacct gaaaaaaaaa aaaaa                              3340




      <210> 155
      <211> 3188
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (925)..(2748)

      <400> 155
 gagagcagta tctcatttct gaacacctgg atgtagcttt cccttgactg tcaaaggagg     60

 tggttttaaa aatcaagcca aacaggtttc catcttttag gaagaccctg gaacgtgcca    120

 gttgattctg accatttctc atgaacagaa acacctagga agggagaact gggatttatt    180

 taatggggat gtgttcaagg caagagcgaa ttcagaagga tatcgacgtc gtgatccaga    240

 agtccagagc tgagaaggac tgcctgtttg cagatttcag atactctgac tccaccttta    300

 cttttaccta cgttggcggc cccagaagtg tatcctactc agtacatgta tctgaagatt    360

 acccagataa tacatatgtg tcaagttcag agaatgatga agatgtgcta gttactacag    420

 agccaatacc agtaattttt catagaatag caacagaatt aagaaaaaac aaatgacatt    480

 aactgttgct tatccataaa atccaaatta caaaaggaaa atggggagga atcaagacag    540

 aatagtacag tggaggaaga ttctgaaggt gacaatgatt ccgaagaatt ttattacgga    600

 gggcaggtga actatgatgg ggaactgcac aagcacccac aactggaagc tgatttgtca    660

 gcagttagag agatatatgg gccacatgca gtttctctca gggaatatgg agccattgat    720

 gatgtagata ttgatctgca tatcgatgtt agctttcttg atgaggagat tgctgtggct    780

 tgggaagtaa ttcgaacaga acctataatt gttcgactac actgttcact tacacagtat    840

 ttaaatggcc cagtgcccac tgttgatgtc tttcagattt ccacaaaaga gcgatttgga    900

 ttgggacatc agctgaaaaa aatc   atg cag aca ttt gtt aca cag cag tgg     951
                              Met Gln Thr Phe Val Thr Gln Gln Trp
                                1               5

 aaa cag agc aaa gaa aaa tcc aat tgc ctg cac aat aaa aag ttg tca      999
 Lys Gln Ser Lys Glu Lys Ser Asn Cys Leu His Asn Lys Lys Leu Ser
  10                  15                  20                  25

 gag aag aaa gtg aag tct ccc ctg cat tta ttt tct act ttg cgc agg     1047
 Glu Lys Lys Val Lys Ser Pro Leu His Leu Phe Ser Thr Leu Arg Arg
                  30                  35                  40

 tcg cca agt tat cct ccc cct ggt tgt ggc aaa agc aaa tcc aaa ctg     1095
 Ser Pro Ser Tyr Pro Pro Pro Gly Cys Gly Lys Ser Lys Ser Lys Leu
              45                  50                  55

 aaa tct gag cag gac gga atc tcc aaa acg cat aag ctg ctg cgg agg     1143
 Lys Ser Glu Gln Asp Gly Ile Ser Lys Thr His Lys Leu Leu Arg Arg
          60                  65                  70

 act tgt tcc agc aca gtc aag act gat gat gtg tgt gtc aca aag tca     1191
 Thr Cys Ser Ser Thr Val Lys Thr Asp Asp Val Cys Val Thr Lys Ser
      75                  80                  85

 cac agg acc ttt ggc cgc tcc ttg tcc agc gat ccc agg gcg gag cag     1239
 His Arg Thr Phe Gly Arg Ser Leu Ser Ser Asp Pro Arg Ala Glu Gln
  90                  95                 100                 105

 gct atg aca gca att aaa tcg cac aaa ctt ttg aac cgt cct tgc cct     1287
 Ala Met Thr Ala Ile Lys Ser His Lys Leu Leu Asn Arg Pro Cys Pro
                 110                 115                 120

 gca gct gtt aag tca gag gaa tgc cta act cta aag tcg cat aga cta     1335
 Ala Ala Val Lys Ser Glu Glu Cys Leu Thr Leu Lys Ser His Arg Leu
             125                 130                 135

 ttg act cga tct tgt tct gga gat cca cga tgt gag cac aac aca aac     1383
 Leu Thr Arg Ser Cys Ser Gly Asp Pro Arg Cys Glu His Asn Thr Asn
         140                 145                 150

 ttg aag ccc cat aaa ctg tta agc agg tct tac tct agt aat ctc aga     1431
 Leu Lys Pro His Lys Leu Leu Ser Arg Ser Tyr Ser Ser Asn Leu Arg
     155                 160                 165

 atg gaa gaa tta tat gga ctg aaa aat cac aaa ttg ctc agc aag tcc     1479
 Met Glu Glu Leu Tyr Gly Leu Lys Asn His Lys Leu Leu Ser Lys Ser
 170                 175                 180                 185

 tac tcc agt gcc ccc aag tca tcc aaa act gag ctt ttc aag gaa cct     1527
 Tyr Ser Ser Ala Pro Lys Ser Ser Lys Thr Glu Leu Phe Lys Glu Pro
                 190                 195                 200

 aac gca gag ggc agg agg ctc tct ctt acc tca ggg ctt att ggt atc     1575
 Asn Ala Glu Gly Arg Arg Leu Ser Leu Thr Ser Gly Leu Ile Gly Ile
             205                 210                 215

 cta aca cca tct tca tct tca tct tct cag ctt gct cca aat ggt gca     1623
 Leu Thr Pro Ser Ser Ser Ser Ser Ser Gln Leu Ala Pro Asn Gly Ala
         220                 225                 230

 aaa tgc att cca gta cga gac cgt ggc ttc ctg gtg cag aca att gag     1671
 Lys Cys Ile Pro Val Arg Asp Arg Gly Phe Leu Val Gln Thr Ile Glu
     235                 240                 245

 ttt gct gaa cag cgg atc cct gta tta aat gaa tat tgt gtg gtt tgt     1719
 Phe Ala Glu Gln Arg Ile Pro Val Leu Asn Glu Tyr Cys Val Val Cys
 250                 255                 260                 265

 gat gag cca cat gtg ttt caa aat ggc cct atg ctt agg cct acc gta     1767
 Asp Glu Pro His Val Phe Gln Asn Gly Pro Met Leu Arg Pro Thr Val
                 270                 275                 280

 tgt gaa cgg gag ctg tgt gtg ttt gct ttt caa acc ctg gga gta atg     1815
 Cys Glu Arg Glu Leu Cys Val Phe Ala Phe Gln Thr Leu Gly Val Met
             285                 290                 295

 aat gaa gct gct gat gaa ata gca act gga gct cag gtg gta gat cta     1863
 Asn Glu Ala Ala Asp Glu Ile Ala Thr Gly Ala Gln Val Val Asp Leu
         300                 305                 310

 cta gta tcc atg tgt agg tct gcg ttg gaa tct cct aga aaa gtt gtg     1911
 Leu Val Ser Met Cys Arg Ser Ala Leu Glu Ser Pro Arg Lys Val Val
     315                 320                 325

 att ttc gag cca tat cct tct gtg gta gat cct aat gat cct cag atg     1959
 Ile Phe Glu Pro Tyr Pro Ser Val Val Asp Pro Asn Asp Pro Gln Met
 330                 335                 340                 345

 ttg gcc ttc aac ccc agg aaa aag aac tat gat cga gta atg aaa gca     2007
 Leu Ala Phe Asn Pro Arg Lys Lys Asn Tyr Asp Arg Val Met Lys Ala
                 350                 355                 360

 ctg gat agc ata act tct atc aga gaa atg aca caa gca cca tat ctg     2055
 Leu Asp Ser Ile Thr Ser Ile Arg Glu Met Thr Gln Ala Pro Tyr Leu
             365                 370                 375

 gaa atc aag aag caa atg gat aaa cag gac ccc ctt gct cat ccc tta     2103
 Glu Ile Lys Lys Gln Met Asp Lys Gln Asp Pro Leu Ala His Pro Leu
         380                 385                 390

 ctg caa tgg gtt ata tca agt aat aga tca cat att gtg aaa ctg cca     2151
 Leu Gln Trp Val Ile Ser Ser Asn Arg Ser His Ile Val Lys Leu Pro
     395                 400                 405

 gtt aac agg caa ttg aag ttt atg cat act cca cat cag ttc ctt ctt     2199
 Val Asn Arg Gln Leu Lys Phe Met His Thr Pro His Gln Phe Leu Leu
 410                 415                 420                 425

 ctc agc agt cca cca gcc aaa gaa tcc aat ttt aga gct gct aaa aaa     2247
 Leu Ser Ser Pro Pro Ala Lys Glu Ser Asn Phe Arg Ala Ala Lys Lys
                 430                 435                 440

 ctc ttt gga agc acc ttt gca ttt cat ggc tca cac att gaa aac tgg     2295
 Leu Phe Gly Ser Thr Phe Ala Phe His Gly Ser His Ile Glu Asn Trp
             445                 450                 455

 cac tcc atc ctg agg aat ggt ctg gtt gtt gct tct aat aca cga ttg     2343
 His Ser Ile Leu Arg Asn Gly Leu Val Val Ala Ser Asn Thr Arg Leu
         460                 465                 470

 cag ctc cat ggt gca atg tat gga agt gga atc tat ctt agt cca atg     2391
 Gln Leu His Gly Ala Met Tyr Gly Ser Gly Ile Tyr Leu Ser Pro Met
     475                 480                 485

 tca agc ata tca ttt ggt tac tca ggg atg aac aag aaa cag aag gtg     2439
 Ser Ser Ile Ser Phe Gly Tyr Ser Gly Met Asn Lys Lys Gln Lys Val
 490                 495                 500                 505

 tca gcc aag gac gag cca gct tca agc agt aaa agc agc aat aca tca     2487
 Ser Ala Lys Asp Glu Pro Ala Ser Ser Ser Lys Ser Ser Asn Thr Ser
                 510                 515                 520

 cag tca cag aaa aaa gga cag caa tcc caa ttc ctg caa agc cgt aac     2535
 Gln Ser Gln Lys Lys Gly Gln Gln Ser Gln Phe Leu Gln Ser Arg Asn
             525                 530                 535

 tta aaa tgc ata gcc tta tgt gaa gtg atc acc tca tct gac ctg cac     2583
 Leu Lys Cys Ile Ala Leu Cys Glu Val Ile Thr Ser Ser Asp Leu His
         540                 545                 550

 aaa cat gga gag ata tgg gtt gtc ccc aat act gac cat gtc tgc aca     2631
 Lys His Gly Glu Ile Trp Val Val Pro Asn Thr Asp His Val Cys Thr
     555                 560                 565

 cga ttc ttt ttc gtc tat gaa gac ggc caa gtg gga gat gca aat att     2679
 Arg Phe Phe Phe Val Tyr Glu Asp Gly Gln Val Gly Asp Ala Asn Ile
 570                 575                 580                 585

 aat aca caa gaa gga ggc att cac aaa gag atc ctc cga gta att ggt     2727
 Asn Thr Gln Glu Gly Gly Ile His Lys Glu Ile Leu Arg Val Ile Gly
                 590                 595                 600

 aat caa act gct act ggt taa ag gaccaccatt taattaacat gattcgaaag     2780
 Asn Gln Thr Ala Thr Gly 
             605

 ccttcctcgg gttcaaagct ggattttgaa ctgaagaaga ttataaaatt atttattgtt   2840

 attataaaca aaattaaccc tttgaatact gatttttttt cttagtattt ctaagtatct   2900

 cattaaatac ctaaaatggt ataagattta tcaattgtag ggttatggaa tctagtaata   2960

 aaatttcaac agcacttaaa ctgaagtttg ggttgctcat acaataaaca gattgaaaaa   3020

 actgttttgt gccgataatt tttatactta aaactcttta actgggtatt cggattatat   3080

 taccgacctt ttaggcttcc caacttccac ttggcacctt tttcatgggt ccaaaaccta   3140

 tccgaaaact tgccccaagt tccgttgccc ccccggtggc catcctca                3188




      <210> 156
      <211> 582
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (376)..(525)

      <400> 156
 gttatttttc ttaagatgta aaaccgataa tacacacaca gtgtggattc aaaaaatacc     60

 aaacaataaa aatggcgccc aagcctttcc cacttctatc tcctgtccct gcagccagga    120

 gccgcctctt taagctcctc ctggaggtgg gctgccgtcc tctgcccctc gtccccacgg    180

 aagaggtcat tctgtagccc agcttttatt ttcgcctaat gtatctctga ggttttaaaa    240

 cattcttttc tagctatcta ttgaacattt actttatgcc agatccagta catgccattg    300

 ttatcctctg tttacaggtg gggaagctga ggcaggaagc cctttagtca cttgccgaag    360

 gccacgctgt taccc atg gga ccg gtt ttg ggc ggc cga aga gca ctc atg     411
                  Met Gly Pro Val Leu Gly Gly Arg Arg Ala Leu Met
                    1               5                  10

 ggg ccg gat tca cgc ccc ggg ccc gtt ccc tcc tgc tct ctg gtg ctc      459
 Gly Pro Asp Ser Arg Pro Gly Pro Val Pro Ser Cys Ser Leu Val Leu
          15                  20                  25

 ctc acg cca ttg gcc cca ctg cct ctc act gcc cgt gag tcc ctg tgc      507
 Leu Thr Pro Leu Ala Pro Leu Pro Leu Thr Ala Arg Glu Ser Leu Cys
      30                  35                  40

 ccg tgt cct cct tct tga acccct cagccctcag ttaaccctca gaaagctggc      561
 Pro Cys Pro Pro Ser 
  45

 tcggagaagt ccttgtgtgg t                                              582




      <210> 157
      <211> 1022
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (504)..(764)

      <400> 157
 ggaacctgaa gtgatttaca cttaatgggt gattaatcca gtattcttta ccctgaatgt     60

 ttggatatta aagttccttt atgttttcta taacctgtgg gatcttcttg cagtgattat    120

 tgtgtgtgag attttttttc tttttggtct atccatattg ttatattcac tcaggtattt    180

 tttttttaat cttattccag aatcagtggt ttatattggg ttactgttta acaccaaatg    240

 gaattggcat tctgcagatt taattaatta tgaaaccagg gtctcatttt ccttgctgat    300

 acttgttgaa aatgagattc acattctagt ctttattttc ctcctgtttt gtccctgtgc    360

 ttgtacatct tccttttatt tgtgtgttat agttctattc catttgagaa ggcagttggt    420

 aagaactaga ttgcatgtac aaagacaggt ttactaagtg ctgtacagtg gtcctgaggt    480

 tacagttgaa ttagaaaaac gaa    atg tac tta cag gaa ata aga aag caa     530
                              Met Tyr Leu Gln Glu Ile Arg Lys Gln
                                1               5

 acc ttt caa atg aga gtg atg att tct tta aaa aaa atc agt ttt ttt      578
 Thr Phe Gln Met Arg Val Met Ile Ser Leu Lys Lys Ile Ser Phe Phe
  10                  15                  20                  25

 ctc tca aat aat gtt ctt tat ttc acg aaa tcg tca atc tta agc atg      626
 Leu Ser Asn Asn Val Leu Tyr Phe Thr Lys Ser Ser Ile Leu Ser Met
                  30                  35                  40

 agc agg gat aaa caa ctc cta gaa gga act caa ttc att ctt cct gga      674
 Ser Arg Asp Lys Gln Leu Leu Glu Gly Thr Gln Phe Ile Leu Pro Gly
              45                  50                  55

 ttt tct ctg ttg tta aat cac aaa aat gat agt ccc caa tcg ttt ctt      722
 Phe Ser Leu Leu Leu Asn His Lys Asn Asp Ser Pro Gln Ser Phe Leu
          60                  65                  70

 tat agg agg tta tta cat ttc att aca gtc act gca ttt tga ctgttgt      771
 Tyr Arg Arg Leu Leu His Phe Ile Thr Val Thr Ala Phe 
      75                  80                  85

 gtttagaatt tgaatgtaca tccaaaatga tgagtttcaa tttaagagcc ttaataaaat    831

 gtgtgagtgt gtctcaattg aataggtttt tctaccttca tttgaagacc ataattcata    891

 ttcatatgaa ttaaccaaac aggaaattca tatgtattat atgtattcat atgtattaac    951

 caaacaggaa aacaacaggt gtcaatggta gcaggttttt gtaaaccatt tttttttttt   1011

 gaaaggaggc c                                                        1022




      <210> 158
      <211> 1290
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(1111)

      <400> 158
 cacgcagcaa gcagaagatc cccgggagtc accctcaacc ctctgtgggc cacgtgggcc     60

 catgaatacc agcctgtctg cgagttagac gccagtcctg gtggcccggg aagcccagat    120

 ccgcatcagc ggttctgcac cccacaccag c   atg tgc tca ctg cct gtg ccc     172
                                      Met Cys Ser Leu Pro Val Pro
                                        1               5

 cgg gag ccc ctg cgt cgc gtg gct gtg act ggg ggc acg cat ggc aac      220
 Arg Glu Pro Leu Arg Arg Val Ala Val Thr Gly Gly Thr His Gly Asn
          10                  15                  20

 gag atg tcg ggc gtc tac ctg gcc cgg cac tgg ctg cat gcc ccc gca      268
 Glu Met Ser Gly Val Tyr Leu Ala Arg His Trp Leu His Ala Pro Ala
      25                  30                  35

 gag ctg cag aga gcc agc ttc tcc gct gtg cct gtg ctg gcc aac ccg      316
 Glu Leu Gln Arg Ala Ser Phe Ser Ala Val Pro Val Leu Ala Asn Pro
  40                  45                  50                  55

 gca gcc aca tcc ggc tgc cgc cgc tac gtg gac cat gac ctc aac cgc      364
 Ala Ala Thr Ser Gly Cys Arg Arg Tyr Val Asp His Asp Leu Asn Arg
                  60                  65                  70

 acc ttc acc agc agc ttc ctc aat tcc agg ccc acc ccg gac gac cca      412
 Thr Phe Thr Ser Ser Phe Leu Asn Ser Arg Pro Thr Pro Asp Asp Pro
              75                  80                  85

 tat gag gtg aca aga gcc cga gag ctg aac cag ctg ctg ggg ccc aag      460
 Tyr Glu Val Thr Arg Ala Arg Glu Leu Asn Gln Leu Leu Gly Pro Lys
          90                  95                 100

 gcc tcg ggc cag gcc ttt gac ttt gtc ctt gac ctg cac aac acc acg      508
 Ala Ser Gly Gln Ala Phe Asp Phe Val Leu Asp Leu His Asn Thr Thr
     105                 110                 115

 gcc aac atg ggc acc tgc tta atc gcg aag tcc tcc cac gaa gtc ttt      556
 Ala Asn Met Gly Thr Cys Leu Ile Ala Lys Ser Ser His Glu Val Phe
 120                 125                 130                 135

 gcc atg cac ctg tgc cgc cat ctg cag ctg cag tac ccc gag ctg tcc      604
 Ala Met His Leu Cys Arg His Leu Gln Leu Gln Tyr Pro Glu Leu Ser
                 140                 145                 150

 tgc cag gtc ttc ctg tac cag cgg tct ggg gag gag agc tac aac ctg      652
 Cys Gln Val Phe Leu Tyr Gln Arg Ser Gly Glu Glu Ser Tyr Asn Leu
             155                 160                 165

 gac tct gtg gcc aaa aat gga ctg ggt ctg gag ctg ggc ccc cag cca      700
 Asp Ser Val Ala Lys Asn Gly Leu Gly Leu Glu Leu Gly Pro Gln Pro
         170                 175                 180

 cag ggt gtg ctg cgg gct gac att ttc tca agg atg agg acc ctg gtg      748
 Gln Gly Val Leu Arg Ala Asp Ile Phe Ser Arg Met Arg Thr Leu Val
     185                 190                 195

 gcc aca gtt ctg gac ttc atc gaa ctc ttc aac cag ggt acg gcc ttt      796
 Ala Thr Val Leu Asp Phe Ile Glu Leu Phe Asn Gln Gly Thr Ala Phe
 200                 205                 210                 215

 cct gcc ttt gag atg gaa gcc tat aga ccc gtg ggc gtc gtg gac ttc      844
 Pro Ala Phe Glu Met Glu Ala Tyr Arg Pro Val Gly Val Val Asp Phe
                 220                 225                 230

 ccc cgc acc gag gcc ggg cac ctg gca ggc act gtg cat cct cag ctg      892
 Pro Arg Thr Glu Ala Gly His Leu Ala Gly Thr Val His Pro Gln Leu
             235                 240                 245

 cag gac cga gac ttc cag cca ctg cag cct ggt gct ccc atc ttc cag      940
 Gln Asp Arg Asp Phe Gln Pro Leu Gln Pro Gly Ala Pro Ile Phe Gln
         250                 255                 260

 atg ttc agt ggg gag gac ctg ctc tat gag gga gag tcc acg gtg tac      988
 Met Phe Ser Gly Glu Asp Leu Leu Tyr Glu Gly Glu Ser Thr Val Tyr
     265                 270                 275

 ccc gtg ttc att aac gag gct gcc tac tat gag aag ggc gtt gcc ttt     1036
 Pro Val Phe Ile Asn Glu Ala Ala Tyr Tyr Glu Lys Gly Val Ala Phe
 280                 285                 290                 295

 gtc cag act gag aag ttc aca ttc acc gtg cct gcc atg ccc gcg ctg     1084
 Val Gln Thr Glu Lys Phe Thr Phe Thr Val Pro Ala Met Pro Ala Leu
                 300                 305                 310

 acc cct gcc ccg agc cca gct tcc taa cccaa gacacacctc cccaacctca     1136
 Thr Pro Ala Pro Ser Pro Ala Ser 
             315

 gtcttcccat ctgaacgatg ggtcctgagg cacagctctg agcacagagg tcccttctgc   1196

 cacctaccat gcaccatgtt ccttgccagg cctccccaac ccctggcctc aatttccctt   1256

 tctataaaat ggaagatgtc cagaaaaaaa aaaa                               1290




      <210> 159
      <211> 990
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (209)..(634)

      <400> 159
 attgctgcct ggtgtgggaa attatgagtc ttattttctg tttattcttt ttacaagaac     60

 atttttataa atgaatgaat gaatgctttc catgggtgga tgaggatccg gcctgccagg    120

 atccaccgtg ggcgccctgc tggcatctga gctgggatgg aaattctatg atgctgatga    180

 ttatcacccg gaggaaaatc gaaggaag   atg gga aaa ggc ata ccg ctc aat     232
                                  Met Gly Lys Gly Ile Pro Leu Asn
                                    1               5

 gac cag gac cgg att cca tgg ctc tgt aac ttg cat gac att tta cta      280
 Asp Gln Asp Arg Ile Pro Trp Leu Cys Asn Leu His Asp Ile Leu Leu
      10                  15                  20

 aga gat gta gcc tcg gga cag cgt gtg gtt cta gcc tgt tca gcc ctg      328
 Arg Asp Val Ala Ser Gly Gln Arg Val Val Leu Ala Cys Ser Ala Leu
  25                  30                  35                  40

 aag aaa acg tac aga gac ata tta aca caa gga aaa gat ggt gta gct      376
 Lys Lys Thr Tyr Arg Asp Ile Leu Thr Gln Gly Lys Asp Gly Val Ala
                  45                  50                  55

 ctg aag tgt gag gag tcg gga aag gaa gca aag cag gct gag atg cag      424
 Leu Lys Cys Glu Glu Ser Gly Lys Glu Ala Lys Gln Ala Glu Met Gln
              60                  65                  70

 ctc ctg gtg gtc cat ctg agc ggg tcg ttt gag gtc atc tct gga cgc      472
 Leu Leu Val Val His Leu Ser Gly Ser Phe Glu Val Ile Ser Gly Arg
          75                  80                  85

 tta ctc aaa aga gag gga cat ttt atg ccc cct gaa tta ttg cag tcc      520
 Leu Leu Lys Arg Glu Gly His Phe Met Pro Pro Glu Leu Leu Gln Ser
      90                  95                 100

 cag ttt gag act ctg gag ccc cca gca gct cca gaa aac ttt atc caa      568
 Gln Phe Glu Thr Leu Glu Pro Pro Ala Ala Pro Glu Asn Phe Ile Gln
 105                 110                 115                 120

 ata agt gtg gac aaa aat gtt tca gag ata att gct aca att atg gaa      616
 Ile Ser Val Asp Lys Asn Val Ser Glu Ile Ile Ala Thr Ile Met Glu
                 125                 130                 135

 acc cta aaa atg aaa tga caatga ttttgtatca gtggtccaaa cagaactaag      670
 Thr Leu Lys Met Lys 
             140

 cataaatcat tgtgccatcc caaacctcgt tccagccgcc ttgcccatac tagattctaa    730

 atgtttctaa aggcaaaccc caatgtgtca agacagactt gtttaggtgt aattttagga    790

 attatgctgg ttcatcagga agcagagggg gagttttaaa agtcaagctt aaattgaagt    850

 ttaaattcat ctataaccaa atcaaatgat cagaggaaat tctgtaatca atgctggaaa    910

 tcgttacatt gtttagaaca ttcttgctca tgcctgtatt tgcacaaata aatgaaactt    970

 cgctgtcaaa aaaaaaaaaa                                                990




      <210> 160
      <211> 1030
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (485)..(859)

      <400> 160
 acttggacga ggtctgaaga cactccacta cctgaattta tttggatcac tgaggaagag     60

 catttgttgg gattacagaa ttataggcca ttagacatca tgggtaggta gtcttaagat    120

 ccttcaactt tcaaaaacca cagtctaagg actatattca aatgacaaga gccgcactgt    180

 atactgcttt ctgcagtgac catgctgggt cacgcatcct atgtttctca tttttaaatg    240

 atttggaaca ttttagccag cattttgatc acacagatta ataatgctgt tctccccaaa    300

 acgggaaact ttacctgaaa cgctctcctg aacaaacacc agtgcactgc cagcctcaca    360

 tgattgcatg ggagctttaa ttaacgctgg agcccagcaa ccttggcttt tcctgcctgt    420

 tatctgctac tgtcacaccg tgaatggtat ttgaatctca cctccctctc acctcagtaa    480

 gagt atg ttt gtt tac agc ccc aac ctc agc aat gcc aaa ggc tgg cat     529
      Met Phe Val Tyr Ser Pro Asn Leu Ser Asn Ala Lys Gly Trp His
        1               5                  10                  15

 cgg ggg cag tgc caa gct gtc cct gga tac tat tta cct ttg agg aag      577
 Arg Gly Gln Cys Gln Ala Val Pro Gly Tyr Tyr Leu Pro Leu Arg Lys
                  20                  25                  30

 aac agc atg ggt ttg cca agc tca att ccc agg ctg gtg ctc ctt gaa      625
 Asn Ser Met Gly Leu Pro Ser Ser Ile Pro Arg Leu Val Leu Leu Glu
              35                  40                  45

 tta atc atg gca cag tgt tca tct ctc tgg aaa tgc cca cgc cag ccc      673
 Leu Ile Met Ala Gln Cys Ser Ser Leu Trp Lys Cys Pro Arg Gln Pro
          50                  55                  60

 aga cac agc ctc aga gtc ctt tcc aac acg acc ctc cag gca gca gtt      721
 Arg His Ser Leu Arg Val Leu Ser Asn Thr Thr Leu Gln Ala Ala Val
      65                  70                  75

 acc aac cat cag tct tca gct gaa gct tca agt ctt tgc cat cct tgt      769
 Thr Asn His Gln Ser Ser Ala Glu Ala Ser Ser Leu Cys His Pro Cys
  80                  85                  90                  95

 aat gac agc ctt agg cct tgc ccc aag cat tct gga ctc tct aac act      817
 Asn Asp Ser Leu Arg Pro Cys Pro Lys His Ser Gly Leu Ser Asn Thr
                 100                 105                 110

 cag aat tgt aat gta ata ttc tgc tct aat tta aat ttt taa aaatata      866
 Gln Asn Cys Asn Val Ile Phe Cys Ser Asn Leu Asn Phe 
             115                 120

 gtctcctaat tcaggataag gagtaagcaa actttctgaa aagggctaga taataagtat    926

 tttaggcttt gccagtcata tggtctcttg cagctactca actctgccac tgtagtatga    986

 aagcagccat gagtaatatg ttaatgaatg ggaatggctg agtt                    1030




      <210> 161
      <211> 862
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (302)..(442)

      <400> 161
 gtgacacata aataagcaga taatatttaa ccaatgaaaa agacttctac cttcttataa     60

 ttaaaattac acatgtctaa gaggaattgt tttatctttt gagtagcttt accgagttgt    120

 atttaaattc taagggccat ttgctaagca gcatttagca tctactcagg gcagttatat    180

 agataaactg ctggacagaa aaattgtaaa atttagcagc ttgattttct gttagcctat    240

 gaaatgttat tgtcctataa aaataacttt aaactgattt aatatttcat atttacatta    300

 t    atg aaa atc aat tac att ata aaa gga atc cct aat gca gaa aca     346
      Met Lys Ile Asn Tyr Ile Ile Lys Gly Ile Pro Asn Ala Glu Thr
        1               5                  10                  15

 aag atg caa ctt tca aaa ttc tta tta ttc cta ttt gta tat aca cga      394
 Lys Met Gln Leu Ser Lys Phe Leu Leu Phe Leu Phe Val Tyr Thr Arg
                  20                  25                  30

 gag aac cca acc agt gcc tgt gtt tgg ggg gaa aag tca aca gtg tag      442
 Glu Asn Pro Thr Ser Ala Cys Val Trp Gly Glu Lys Ser Thr Val 
              35                  40                  45

 ttctaaacct tatcccaaac agaaaatgtg gttaatgatg tcactttcct tgctggtcat    502

 cattaggctt aaattaaatg ctgaagctgt catcaaagag tttacactaa aatcttcagg    562

 gctttaaata aaaggttaag tccagcttcc aaacacaatt ttccacatta gcagctccaa    622

 tcttcttaaa taaagctctg ttttcctata tttttatgac tgctgagacc ccacagggac    682

 caatatttgt attcaaatta catttcatgg tttcccattg tttcacaatg agttctaata    742

 aatgggattt actataataa tccaagtatg acatagccgg tatgctttca tgaatgtttt    802

 tatgtagatt ttcctcccat gaacatgagt aaataaatct gtttcctgaa aaaaaaaaaa    862




      <210> 162
      <211> 2338
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1088)..(1291)

      <400> 162
 ggaatgtcct caggaatact tcagaaatag aaggtatgca atcccttagt ggggggcaaa     60

 cacatttcag atttcgtctt tatttaaaag gatcttcagt ctacaacatt tgcttttttc    120

 gtgctttgga aaatatcctt gtgcagataa gttcttctgt ttgaaacaag catgaaacat    180

 tggtccaata acctaagaat gtggagattt cttgatattc tgtattaatt aaagttctct    240

 acatgtctca aatggagatc acaaaacatg aaaaggaaga aatgaaatat cttttcttct    300

 gggatgagtg tcaattttaa tgtataattg tcataatcaa tcagccaaaa gttacaatct    360

 gtccctcaga gacattgggg gaagctgatg gatttccagt aaggaactgt ggtgggttca    420

 aactcaggct gccacaaata cattgatatg gtaggtagga agtaggacta aatttgaaag    480

 aaacttatgg gataaagttc acaattttaa aaaggttgcc ctccagtttt tttgtttgtt    540

 tataaactag agtgattttt aagtaaccct tatatttaag gctgcaaaaa atgtacaaga    600

 gtatgttttc aagtaaaggg aacataattc ttcaaaaagc tgttgaactg gagttatgat    660

 aggttatgac agagagcatg atcagtgctg atactgacaa gtactttttt accttaaaat    720

 caacttctat ggaactacaa gatcaatcta gctcccgagt gacattttcc attgtctgta    780

 ataatgccct cggatgagtt gtgtctaaaa ttaagttcat ctttatttat atgcgaactt    840

 aactgccata gtccctaatg tattgcattt gtaacctgat cgtattatgt ttacagctga    900

 aagatttcat ctagacatgt ctttcgtcct tattattcaa aggggaattg aaagagatat    960

 ttagtattaa gacatgttcc ccaattgaga attttccaga atattctact taagaagaag   1020

 aagagcaatt aactgccttt agtgtaaggg cgagagtgca tagaaatatg caatgtaaaa   1080

 tgtttgc  atg aat tat ttc aca tca tgt aag ctt tcc cat att cat aag    1129
          Met Asn Tyr Phe Thr Ser Cys Lys Leu Ser His Ile His Lys
            1               5                  10

 atg aac act ata gaa gtc tca ttt ctc tgt gat ctt ctg tcc att agg     1177
 Met Asn Thr Ile Glu Val Ser Phe Leu Cys Asp Leu Leu Ser Ile Arg
  15                  20                  25                  30

 aaa gta agg aga ttg tta tct ata tct agt ctc ctt tcc ata ttg aac     1225
 Lys Val Arg Arg Leu Leu Ser Ile Ser Ser Leu Leu Ser Ile Leu Asn
                  35                  40                  45

 tgc atg gct cta atc ctc agt gta ttt tta tcc ctt ctc gag tta ttt     1273
 Cys Met Ala Leu Ile Leu Ser Val Phe Leu Ser Leu Leu Glu Leu Phe
              50                  55                  60

 aaa att tgc cct att taa gctgaa gcctggataa actgctgagc cagattattc     1327
 Lys Ile Cys Pro Ile 
          65

 ctgtgattgg agtttaattg ctgtagaaca cttgttgaga acacattttt tacttttttt   1387

 ctttcagaat tattcctcaa tcattgttct ctaatgaaaa caccgagaag taaatctggt   1447

 gcttcttagt gtaaatatgt ttttcttttt aaaaagtcat tttaaaacaa agatgagaga   1507

 actataaagt aaggggaaat atcattttat ttaaaaataa ttattcaatg atagataatg   1567

 gagatacaga atgactcatt gggttcatag gtatgatttg tgcagccagt cttagaggaa   1627

 atacatcatt ttaacattat tcccacaaaa tgttaaagct caatggtttg actatgagag   1687

 tcaaacaatt actatttgaa aatctcttat gacattttta taatctactc tgtttttatt   1747

 tgcatgatta tgcttatgtg atgaaccatc catgattctg atattgtatt tctttccagt   1807

 attaacatgt gtattgtgtg gccaactctg atttgtacac cgtattattg ttgtaatgat   1867

 tcaactgttc ctacatttaa ttgcagttta attattatgc cttttggggt taaatgatgt   1927

 gaagtgtttc cacctactga taaataccat atgaaaacat gactaaaaga ctgatttaag   1987

 aaacttgtta tttttaaaaa tatgaatttc aaaagaaatg ttctcaaaga cacatgcatt   2047

 tattttaaat tcaaaaaatt cttatgaatt tattattgct tgtactttaa ctttttttat   2107

 tgtagacaat cctaagtgaa taatgtctca tgggagaaca catgatatgt gcttgtattt   2167

 gtgtaatctg atcatgcact caatggttgg aaaaggcact ccagtgctaa gaaaataacc   2227

 agaagccaat atatcgattc ttatatctcg gtttatgtta ccaactgaat atggtgtaat   2287

 gcataacttt ttccagtaaa taaactggtt attttttgtt aaaaaaaaaa a            2338




      <210> 163
      <211> 2074
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1695)..(1844)

      <400> 163
 ctttgacttt gaaagccgat ctgagattgc aaacctcatc ttggctgaga actgcgaggc     60

 tgccctggct cttcatctct ataggggagg caggcttttg caaggccacc gaatcccttt    120

 tggagtcatc tttggtggaa ctgatgtaaa tgaagatgcc aaccaggcgg aaaaaaacac    180

 agtcatgggc agagttcttg aggaagccag atttgctgtc gctttcacag agtcaatgaa    240

 ggaaatggca caagcgcagt gggtcgatcc agtgtttaca agggaagtga aagccaaagt    300

 gaaaagagcc gctggggtac gattgattgg agagatgcct caagaagatc tgcacgcggt    360

 ggtgaagaat tgcttcgcgg tggtgaatag ctctgtctct gaaggcatgt cagctgcaat    420

 tttggaggca atggatttag aagtaccggt attggccagg aacatccccg ggaatgctgc    480

 cgtggtgaag catgaagtca cagggctact gttttccaat cctcaggagt ttgttcatct    540

 ggcaaagaga ctggttagtg atcctgcatt agaaaaggaa atcgtagtga acggaaggga    600

 atacgtgaga atgtatcatt catggcaggt ggaaagagac acctaccaac agctcatcag    660

 gaagctggaa ggaagcactg aagattgagg gccccgcctc atcagacacc tgctctctga    720

 cacacagctc tgggtgcaca ctcagagaca gagttctgga tcacgtgggc ccagtgcagt    780

 tcaaataaaa ccagcctcag cggaatccta gaaaatgtta gtcgtgagtc cccagagcca    840

 ctgcattcat cccatatcct tctgtgcgtt cagatgctgt cccaggcgtg ttcaccagcc    900

 agtcctgatg gaggtgcatg agtgactggg ttgactggga cagggaaagg ggaactggtt    960

 ttcagggaat ttgggagaga atttgattac ctgccttagg gctttggtgt ggacaataga   1020

 ggcttatttt caagcagtca tggttcagac tcctcccgcc tgccttctga ccaacctctc   1080

 cccatcgttg ccagtttgaa aggcaaaagc aaaacagacg tgtcagctga gccgagtcct   1140

 cgcaggattt ttgttgtgat ctcaggactc tgacaggcac gtgggtgacc cgaggcttct   1200

 ctgaacacta gaaagcgctg tgagtgagct cacgcccggc acagctcact tttcaatggt   1260

 ggaattgaaa gttgtgcttt ttagaaaagt ggccaggctg cccgcaggcc ccgcccacct   1320

 cttggctgaa tttgagtgga aaaccaggaa ggaacaagcg ccacgtcacg catagcctgc   1380

 aaatcgcccg cgtgaccctg agatggaggc ctgaggcttt gggtccaggg tgggctcttc   1440

 cccttcccac atcagggacc cggggatgga tgtcggaagg gtcaccagcc tccagccttt   1500

 ggcaggatgg agcttgggtc tgcagggctt tgcagccaca cagcgaggtc agtccggggc   1560

 cagccgcgcc atcatggtaa tggtggcctc gccccatcca tgtcatccat gtcacatgag   1620

 gacgtgcagt cttccttgtc ctctcctagt ggaatttgcc tgggagaacc tccactgaat   1680

 actgaaattg ttgc  atg cct gtg gat tcc tta cga caa tgg gga acg cgg    1730
                  Met Pro Val Asp Ser Leu Arg Gln Trp Gly Thr Arg
                    1               5                  10

 tgt ttc cca cct ctt gtg ggt aga aag cag tct gct ttg agg agg cga     1778
 Cys Phe Pro Pro Leu Val Gly Arg Lys Gln Ser Ala Leu Arg Arg Arg
          15                  20                  25

 gaa ggc aaa gcc agg gca ggg cgt tgc tgt ggg aag cgt tcg gtg aaa     1826
 Glu Gly Lys Ala Arg Ala Gly Arg Cys Cys Gly Lys Arg Ser Val Lys
      30                  35                  40

 gcg ggt ttc gac gct tag gagggc cgagggagaa gattccacca gcattgtcct     1880
 Ala Gly Phe Asp Ala 
  45

 tgcttcaagt tttaggatgt ctgaactttc agctttcatg ttttcaacca tcattttttt   1940

 aatggcacaa cctacatctt tttaaaagaa gtagcctcaa attaaactcc ttaaactctg   2000

 atgccctggg gatgagaaca actagcttgg atctcgtgcc gtgtaattca atgtttcatt   2060

 ccgctgcctc catc                                                     2074




      <210> 164
      <211> 1175
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (153)..(1013)

      <400> 164
 gtagcctttt ttttgggcgg ccaaaaatac caagttttcc tgggaaatgg gtggagtatg     60

 cttacaaaaa atactgtggt tagaaacaaa gaatcgcatg ataaaaatat aggataaaaa    120

 ctccaagtct ataagtagag ccttcctccc ag  atg ctc ttc tcc tgg gcc atg     173
                                      Met Leu Phe Ser Trp Ala Met
                                        1               5

 cag agg agg aag aca cgt gct aaa gaa act gga gcc aaa tgt cta gac      221
 Gln Arg Arg Lys Thr Arg Ala Lys Glu Thr Gly Ala Lys Cys Leu Asp
          10                  15                  20

 act gac tta gga agc tgc tgc gta cca caa aag ggc tac cac aat aaa      269
 Thr Asp Leu Gly Ser Cys Cys Val Pro Gln Lys Gly Tyr His Asn Lys
      25                  30                  35

 gag ctg ggc gct gcc gag gct cgg ggc gcg cgc agt tgg cgt ctg cca      317
 Glu Leu Gly Ala Ala Glu Ala Arg Gly Ala Arg Ser Trp Arg Leu Pro
  40                  45                  50                  55

 gtg cca aga ctg tgc cgc ccc cac agc cga ggc gcg aaa ggg gga cgc      365
 Val Pro Arg Leu Cys Arg Pro His Ser Arg Gly Ala Lys Gly Gly Arg
                  60                  65                  70

 ccg gcc tct ggg ccg ctg cct tcg ctt tct ctt cgt tgt tgc gaa cgc      413
 Pro Ala Ser Gly Pro Leu Pro Ser Leu Ser Leu Arg Cys Cys Glu Arg
              75                  80                  85

 cgt ccg ctc agg agg cgc ccc gcg acc ggc gcg atg agt gcc aac gag      461
 Arg Pro Leu Arg Arg Arg Pro Ala Thr Gly Ala Met Ser Ala Asn Glu
          90                  95                 100

 gac cag gag atg gaa cta gaa gca tta cgc tct att tat gaa gga gat      509
 Asp Gln Glu Met Glu Leu Glu Ala Leu Arg Ser Ile Tyr Glu Gly Asp
     105                 110                 115

 gaa agt ttc cgg gaa tta agt cca gtt tct ttt caa tat agg ata ggt      557
 Glu Ser Phe Arg Glu Leu Ser Pro Val Ser Phe Gln Tyr Arg Ile Gly
 120                 125                 130                 135

 gaa aat ggt gat ccc aaa gcc ttc tta ata gag att tcc tgg aca gaa      605
 Glu Asn Gly Asp Pro Lys Ala Phe Leu Ile Glu Ile Ser Trp Thr Glu
                 140                 145                 150

 aca tat ccc caa aca cct cca att cta tct atg aac gct ttt ttt aac      653
 Thr Tyr Pro Gln Thr Pro Pro Ile Leu Ser Met Asn Ala Phe Phe Asn
             155                 160                 165

 aac acc ata tca tca gct gta aag cag agt ata tta gcc aag cta cag      701
 Asn Thr Ile Ser Ser Ala Val Lys Gln Ser Ile Leu Ala Lys Leu Gln
         170                 175                 180

 gaa gca gta gaa gct aat ctt gga acc gct atg acc tat aca ttg ttt      749
 Glu Ala Val Glu Ala Asn Leu Gly Thr Ala Met Thr Tyr Thr Leu Phe
     185                 190                 195

 gaa tat gcc aaa gac aat aaa gag cag ttc atg gag aat cac aat ccc      797
 Glu Tyr Ala Lys Asp Asn Lys Glu Gln Phe Met Glu Asn His Asn Pro
 200                 205                 210                 215

 atc aat tcc gca aca tcg ata agc aat atc atc tca att gaa act cct      845
 Ile Asn Ser Ala Thr Ser Ile Ser Asn Ile Ile Ser Ile Glu Thr Pro
                 220                 225                 230

 aat aca gcc cca tca agt aag aaa aaa gac aaa aaa gaa caa ctt tca      893
 Asn Thr Ala Pro Ser Ser Lys Lys Lys Asp Lys Lys Glu Gln Leu Ser
             235                 240                 245

 aaa gcc cag aag cgt aag ctg gca gac aaa aca gat cac aaa gga gaa      941
 Lys Ala Gln Lys Arg Lys Leu Ala Asp Lys Thr Asp His Lys Gly Glu
         250                 255                 260

 ctt cct cga ggc tgg aac tgg gtt gat gtt gtg aag cat tta agc aaa      989
 Leu Pro Arg Gly Trp Asn Trp Val Asp Val Val Lys His Leu Ser Lys
     265                 270                 275

 act ggc tct aag gat gat gag tag cacttggaat ttgagacaag gaaagagcat    1043
 Thr Gly Ser Lys Asp Asp Glu 
 280                 285

 tctttaaaga gtaaaactgg gttcaaaatc tttcattact attttctggt attgaggcga   1103

 ctttttataa aacacaattt tttgtatgtt tcttacatta aaaaggttgt aagttgaaag   1163

 ttaaaaaaaa aa                                                       1175




      <210> 165
      <211> 1142
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (877)..(1095)

      <400> 165
 ggtatccgtc cgagtgcgtt tcactcgggt ttttattaag gcgttcgtga tatttttggt     60

 acactggacg ccctttttat tttaagaaag ggtttccctt ttatatggaa gtgcctaatt    120

 ttcaaggtgc ccccatttta tattgaggta atattttatt ttttgaataa attcatttcg    180

 gttatattaa aagcataagg aaatttccat gtatgtaaaa ataacttaga aagtcagtgc    240

 ataattcatg attgaataca tgatggtaat tgacgtgctt tttttttttc tgcagtggac    300

 aaataaacat cctcaaagta gcaactgcaa atcagttacc cttagaaaag caagaccaaa    360

 cactgtagtt acactattag cagtgaccaa aaagggctaa tattttctaa gaatagttta    420

 aattacagac atttgttata tttaccttat gtgaaataca tcactattta attacattaa    480

 ttttaacatc tgttgtgtgg agttgtatag ttcatgcaaa agcctgtggg tatgggtttt    540

 tcaaaccagc agaaaggtca aaggtacctg aatgctaaac tgcctggctc ccagcttttt    600

 cattaaactt ttcagggtct tggtttcttt atctgtaaaa tgacagagtt ggaccagtta    660

 actttaatgg ccatcctttt acaccacaca agttgataaa atttatctgt tcagcaaaga    720

 gattgaacaa aaaagcacgt tagtaatatg aagacaggaa aacgaatgaa agtctaacac    780

 ataactcata ttgatttact ttatttctgt tagattttac actctgaaaa tttcacctca    840

 tttagtttgt acaaatacta gacatggaaa cttaaa  atg tgc agg tgt caa agc     894
                                          Met Cys Arg Cys Gln Ser
                                            1               5

 tta aaa atc agg tgt gtc ctc ttt aaa ggc atg tgc gat aag cct gca      942
 Leu Lys Ile Arg Cys Val Leu Phe Lys Gly Met Cys Asp Lys Pro Ala
              10                  15                  20

 gtc tta acc aga cct ggt acc agt tta aca gtt cat tat act tct gtg      990
 Val Leu Thr Arg Pro Gly Thr Ser Leu Thr Val His Tyr Thr Ser Val
          25                  30                  35

 atg agt gga tct gtt agt ctg gta gag att aat gtt gaa att tac ttg     1038
 Met Ser Gly Ser Val Ser Leu Val Glu Ile Asn Val Glu Ile Tyr Leu
      40                  45                  50

 aat tac agt tat ttg aca agc cca ctt ttt ttg gag ttt ggt gag gaa     1086
 Asn Tyr Ser Tyr Leu Thr Ser Pro Leu Phe Leu Glu Phe Gly Glu Glu
  55                  60                  65                  70

 gat aag taa aaatgcc caactagtac aatgtggaga aagttttctg tttgcttgac     1142
 Asp Lys 






      <210> 166
      <211> 2291
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (364)..(1878)

      <400> 166
 aagggtcctc cgattgctag cacacagcgg tgagcagaga aggtaggtga ggaactgcac     60

 tgactcagct gcagagggcg gcggcagccc gcccctgggg cgggagaagg gcaggagccg    120

 ggagacacca ggaagctctt ccccgcccgg gcacgtaaca gagctgggag cctggctgcc    180

 aggggcgtgt tatcgcgggg gcagcctggg agcgctgctg cgccgcggca ggagaaacag    240

 ccgaggacac cctggaagag caggagcacg tgggcctgcg agaatggcgc caacaccagc    300

 cctgcaaagc cacattccaa agccgggcca aggacagcca ccgttgcccc gcaggcctca    360

 agg  atg acg gtc aag cca gcc aag gcc gcc tcc cta gcc agg aac ctc     408
      Met Thr Val Lys Pro Ala Lys Ala Ala Ser Leu Ala Arg Asn Leu
        1               5                  10                  15

 gca aag cgc agg cgc acc tac ctg ggt ggc gcg gct ggg cgg agt caa      456
 Ala Lys Arg Arg Arg Thr Tyr Leu Gly Gly Ala Ala Gly Arg Ser Gln
                  20                  25                  30

 gag ccg gaa gtc cct tgt gcc gca gtc ctt ccc ggg aaa cct ggg gac      504
 Glu Pro Glu Val Pro Cys Ala Ala Val Leu Pro Gly Lys Pro Gly Asp
              35                  40                  45

 cgg aac tgc ccg gag ttc ccg ccc cca gac aga acc ctg ggt tgc tgg      552
 Arg Asn Cys Pro Glu Phe Pro Pro Pro Asp Arg Thr Leu Gly Cys Trp
          50                  55                  60

 gca acc gat gcg gcc ccc gca gct ggt ctc tgt ggt gct ggg agc gag      600
 Ala Thr Asp Ala Ala Pro Ala Ala Gly Leu Cys Gly Ala Gly Ser Glu
      65                  70                  75

 ccc agt ata gct ccc acc tcc tgc gct ggt aac ctc ccg tcc cgc ccg      648
 Pro Ser Ile Ala Pro Thr Ser Cys Ala Gly Asn Leu Pro Ser Arg Pro
  80                  85                  90                  95

 cct ccc ttg ttg tcg cct ctc ctc gcg tcg cgg aat cct tgc cct tgg      696
 Pro Pro Leu Leu Ser Pro Leu Leu Ala Ser Arg Asn Pro Cys Pro Trp
                 100                 105                 110

 cac tac tta cat ctc tcc ggg tcc cac aac acc tta gcg ccc acc tgc      744
 His Tyr Leu His Leu Ser Gly Ser His Asn Thr Leu Ala Pro Thr Cys
             115                 120                 125

 ttc aaa gcc aag ctc cac cga aag cga ggc agt cag ccc ccg gac atg      792
 Phe Lys Ala Lys Leu His Arg Lys Arg Gly Ser Gln Pro Pro Asp Met
         130                 135                 140

 gcc tca gcg ctg act gat cgc acc tct cgg gcc ccg agc acc tac acc      840
 Ala Ser Ala Leu Thr Asp Arg Thr Ser Arg Ala Pro Ser Thr Tyr Thr
     145                 150                 155

 tac acc agc cgg ccc cga gca ctg ccc tgc cag cgc agc cgt tac cgg      888
 Tyr Thr Ser Arg Pro Arg Ala Leu Pro Cys Gln Arg Ser Arg Tyr Arg
 160                 165                 170                 175

 gac agc ctg acg cag cca gat gaa gaa cct atg cat tat gga aac ata      936
 Asp Ser Leu Thr Gln Pro Asp Glu Glu Pro Met His Tyr Gly Asn Ile
                 180                 185                 190

 atg tat gac aga agg gta att cga ggt aac act tat gca ctc cag aca      984
 Met Tyr Asp Arg Arg Val Ile Arg Gly Asn Thr Tyr Ala Leu Gln Thr
             195                 200                 205

 ggg cca ctg ctc gga cgg cct gat tct cta gag ctc cag aga caa cgg     1032
 Gly Pro Leu Leu Gly Arg Pro Asp Ser Leu Glu Leu Gln Arg Gln Arg
         210                 215                 220

 gag gct agg aag agg gct ctt gcc aga aaa caa gcc caa gag cag ctc     1080
 Glu Ala Arg Lys Arg Ala Leu Ala Arg Lys Gln Ala Gln Glu Gln Leu
     225                 230                 235

 aga cca caa aca cct gaa cct gtg gaa ggc aga aag cat gtc gat gtg     1128
 Arg Pro Gln Thr Pro Glu Pro Val Glu Gly Arg Lys His Val Asp Val
 240                 245                 250                 255

 caa aca gtt aaa cca gtg tta gaa gtt ttg gtg ggg aag aca att gag     1176
 Gln Thr Val Lys Pro Val Leu Glu Val Leu Val Gly Lys Thr Ile Glu
                 260                 265                 270

 cag tct ctt ctg gaa gta atg gaa gaa gaa gag ctg gct aac ctg cgg     1224
 Gln Ser Leu Leu Glu Val Met Glu Glu Glu Glu Leu Ala Asn Leu Arg
             275                 280                 285

 gcc agt cag cgt gag tat gaa gaa cta cgg aat agt gaa cgt gct gaa     1272
 Ala Ser Gln Arg Glu Tyr Glu Glu Leu Arg Asn Ser Glu Arg Ala Glu
         290                 295                 300

 gtt caa cga ctt gaa gag caa gag agg cga cac cga gaa gaa aaa gaa     1320
 Val Gln Arg Leu Glu Glu Gln Glu Arg Arg His Arg Glu Glu Lys Glu
     305                 310                 315

 cgg cgt aag aaa cag cag tgg gaa ata atg cac aag cac aac gag aca     1368
 Arg Arg Lys Lys Gln Gln Trp Glu Ile Met His Lys His Asn Glu Thr
 320                 325                 330                 335

 tca caa aaa atc gcc gcc cga gca ttt gca cag cgt tac ctg gct gac     1416
 Ser Gln Lys Ile Ala Ala Arg Ala Phe Ala Gln Arg Tyr Leu Ala Asp
                 340                 345                 350

 ctt ctc ccg tct gtt ttt ggc agc ctc agg gat agt ggc tac ttt tat     1464
 Leu Leu Pro Ser Val Phe Gly Ser Leu Arg Asp Ser Gly Tyr Phe Tyr
             355                 360                 365

 gat ccc att gaa aga gat att gag ata gga ttt ctt cca tgg cta atg     1512
 Asp Pro Ile Glu Arg Asp Ile Glu Ile Gly Phe Leu Pro Trp Leu Met
         370                 375                 380

 aat gaa gtt gaa aaa acc atg gaa tat agc atg gtg gga aga aca gtg     1560
 Asn Glu Val Glu Lys Thr Met Glu Tyr Ser Met Val Gly Arg Thr Val
     385                 390                 395

 ctt gac atg ttg atc cgt gag gtg gtt gaa aag agg ctg tgt atg tat     1608
 Leu Asp Met Leu Ile Arg Glu Val Val Glu Lys Arg Leu Cys Met Tyr
 400                 405                 410                 415

 gag cat ggg gaa gac aca cat cag tct cca gaa ccc gag gat gag cct     1656
 Glu His Gly Glu Asp Thr His Gln Ser Pro Glu Pro Glu Asp Glu Pro
                 420                 425                 430

 ggt ggt cct gga gca atg aca gag tca ctg gag gcc tct gaa ttc ctg     1704
 Gly Gly Pro Gly Ala Met Thr Glu Ser Leu Glu Ala Ser Glu Phe Leu
             435                 440                 445

 gag cag agc atg tca cag aca cgg gag ctg ctt tta gat gga ggc tac     1752
 Glu Gln Ser Met Ser Gln Thr Arg Glu Leu Leu Leu Asp Gly Gly Tyr
         450                 455                 460

 cta caa aga aca aca tat gac aga agg tca tcc cag gaa agg aag ttt     1800
 Leu Gln Arg Thr Thr Tyr Asp Arg Arg Ser Ser Gln Glu Arg Lys Phe
     465                 470                 475

 atg gaa gag aga gaa ctc tta ggg caa gat gaa gaa aca gca atg agg     1848
 Met Glu Glu Arg Glu Leu Leu Gly Gln Asp Glu Glu Thr Ala Met Arg
 480                 485                 490                 495

 aag tcc tta ggg gag gaa gaa ttg tca tag g agggaagctt caaagtcatg     1899
 Lys Ser Leu Gly Glu Glu Glu Leu Ser 
                 500

 aaaccaatca acagccaagt cagcaagcaa tcaggtaatg atgtgcgagt cccctcaggt   1959

 tatagaaatt atgttgtatt tagtcagtat gtctttttgt gtaatggact gggccaatca   2019

 aatgtgataa aattaatttg agaatgaaac ttaaattgaa ttcatttatt taatagaata   2079

 ttcaaaggct atattgtaat tctaatgaga attatattta attactagct ttctattacc   2139

 attatatgta accagcaaat atatttttcc ttagcccttc taattttgcg ggttagtttt   2199

 ttttagtaag tatgatattt aatgttcaat atcagtgctg tcagccatat agcttttctt   2259

 ctctatagga aaactatttc acctactgta ag                                 2291




      <210> 167
      <211> 2459
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (364)..(2046)

      <400> 167
 aagggtcctc cgattgctag cacacagcgg tgagcagaga aggtaggtga ggaactgcac     60

 tgactcagct gcagagggcg gcggcagccc gcccctgggg cgggagaagg gcaggagccg    120

 ggagacacca ggaagctctt ccccgcccgg gcacgtaaca gagctgggag cctggctgcc    180

 aggggcgtgt tatcgcgggg gcagcctggg agcgctgctg cgccgcggca ggagaaacag    240

 ccgaggacac cctggaagag caggagcacg tgggcctgcg agaatggcgc caacaccagc    300

 cctgcaaagc cacattccaa agccgggcca aggacagcca ccgttgcccc gcaggcctca    360

 agg  atg acg gtc aag cca gcc aag gcc gcc tcc cta gcc agg aac ctc     408
      Met Thr Val Lys Pro Ala Lys Ala Ala Ser Leu Ala Arg Asn Leu
        1               5                  10                  15

 gca aag cgc agg cgc acc tac ctg ggt ggc gcg gct ggg cgg agt caa      456
 Ala Lys Arg Arg Arg Thr Tyr Leu Gly Gly Ala Ala Gly Arg Ser Gln
                  20                  25                  30

 gag ccg gaa gtc cct tgt gcc gca gtc ctt ccc ggg aaa cct ggg gac      504
 Glu Pro Glu Val Pro Cys Ala Ala Val Leu Pro Gly Lys Pro Gly Asp
              35                  40                  45

 cgg aac tgc ccg gag ttc ccg ccc cca gac aga acc ctg ggt tgc tgg      552
 Arg Asn Cys Pro Glu Phe Pro Pro Pro Asp Arg Thr Leu Gly Cys Trp
          50                  55                  60

 gca acc gat gcg gcc ccc gca gct ggt ctc tgt ggt gct ggg agc gag      600
 Ala Thr Asp Ala Ala Pro Ala Ala Gly Leu Cys Gly Ala Gly Ser Glu
      65                  70                  75

 ccc agt ata gct ccc acc tcc tgc gct ggt aac ctc ccg tcc cgc ccg      648
 Pro Ser Ile Ala Pro Thr Ser Cys Ala Gly Asn Leu Pro Ser Arg Pro
  80                  85                  90                  95

 cct ccc ttg ttg tcg cct ctc ctc gcg tcg cgg aat cct tgc cct tgg      696
 Pro Pro Leu Leu Ser Pro Leu Leu Ala Ser Arg Asn Pro Cys Pro Trp
                 100                 105                 110

 cac tac tta cat ctc tcc ggg tcc cac aac acc tta gcg ccc acc tgc      744
 His Tyr Leu His Leu Ser Gly Ser His Asn Thr Leu Ala Pro Thr Cys
             115                 120                 125

 ttc aaa gcc aag ctc cac cga aag cga ggc agt cag ccc ccg gac atg      792
 Phe Lys Ala Lys Leu His Arg Lys Arg Gly Ser Gln Pro Pro Asp Met
         130                 135                 140

 gcc tca gcg ctg act gat cgc acc tct cgg gcc ccg agc acc tac acc      840
 Ala Ser Ala Leu Thr Asp Arg Thr Ser Arg Ala Pro Ser Thr Tyr Thr
     145                 150                 155

 tac acc agc cgg ccc cga gca ctg ccc tgc cag cgc agc cgt tac cgg      888
 Tyr Thr Ser Arg Pro Arg Ala Leu Pro Cys Gln Arg Ser Arg Tyr Arg
 160                 165                 170                 175

 gac agc ctg acg cag cca gat gaa gaa cct atg cat tat gga aac ata      936
 Asp Ser Leu Thr Gln Pro Asp Glu Glu Pro Met His Tyr Gly Asn Ile
                 180                 185                 190

 atg tat gac aga agg gta att cga ggt aac act tat gca ctc cag aca      984
 Met Tyr Asp Arg Arg Val Ile Arg Gly Asn Thr Tyr Ala Leu Gln Thr
             195                 200                 205

 ggg cca ctg ctc gga cgg cct gat tct cta gag ctc cag aga caa cgg     1032
 Gly Pro Leu Leu Gly Arg Pro Asp Ser Leu Glu Leu Gln Arg Gln Arg
         210                 215                 220

 gag gct agg aag agg gct ctt gcc aga aaa caa gcc caa gag cag ctc     1080
 Glu Ala Arg Lys Arg Ala Leu Ala Arg Lys Gln Ala Gln Glu Gln Leu
     225                 230                 235

 aga cca caa aca cct gaa cct gtg gaa ggc aga aag cat gtc gat gtg     1128
 Arg Pro Gln Thr Pro Glu Pro Val Glu Gly Arg Lys His Val Asp Val
 240                 245                 250                 255

 caa aca gaa tta tac ctt gaa gaa att gct gat cgc ata ata gaa gtt     1176
 Gln Thr Glu Leu Tyr Leu Glu Glu Ile Ala Asp Arg Ile Ile Glu Val
                 260                 265                 270

 gat atg gaa tgc caa aca gat gca ttt ttg gac aga cca cca aca cca     1224
 Asp Met Glu Cys Gln Thr Asp Ala Phe Leu Asp Arg Pro Pro Thr Pro
             275                 280                 285

 ctc ttt att cct gcc aaa act ggc aaa gat gtg gcc acc caa ata cta     1272
 Leu Phe Ile Pro Ala Lys Thr Gly Lys Asp Val Ala Thr Gln Ile Leu
         290                 295                 300

 gaa gga gag ctc ttt gac ttt gat ctt gaa gtt aaa cca gtg tta gaa     1320
 Glu Gly Glu Leu Phe Asp Phe Asp Leu Glu Val Lys Pro Val Leu Glu
     305                 310                 315

 gtt ttg gtg ggg aag aca att gag cag tct ctt ctg gaa gta atg gaa     1368
 Val Leu Val Gly Lys Thr Ile Glu Gln Ser Leu Leu Glu Val Met Glu
 320                 325                 330                 335

 gaa gaa gag ctg gct aac ctg cgg gcc agt cag cgt gag tat gaa gaa     1416
 Glu Glu Glu Leu Ala Asn Leu Arg Ala Ser Gln Arg Glu Tyr Glu Glu
                 340                 345                 350

 cta cgg aat agt gaa cgt gct gaa gtt caa cga ctt gaa gag caa gag     1464
 Leu Arg Asn Ser Glu Arg Ala Glu Val Gln Arg Leu Glu Glu Gln Glu
             355                 360                 365

 agg cga cac cga gaa gaa aaa gaa cgg cgt aag aaa cag cag tgg gaa     1512
 Arg Arg His Arg Glu Glu Lys Glu Arg Arg Lys Lys Gln Gln Trp Glu
         370                 375                 380

 ata atg cac aag cac aac gag aca tca caa aaa atc gcc gcc cga gca     1560
 Ile Met His Lys His Asn Glu Thr Ser Gln Lys Ile Ala Ala Arg Ala
     385                 390                 395

 ttt gca cag cgt tac ctg gct gac ctt ctc ccg tct gtt ttt ggc agc     1608
 Phe Ala Gln Arg Tyr Leu Ala Asp Leu Leu Pro Ser Val Phe Gly Ser
 400                 405                 410                 415

 ctc agg gat agt ggc tac ttt tat gat ccc att gaa aga gat att gag     1656
 Leu Arg Asp Ser Gly Tyr Phe Tyr Asp Pro Ile Glu Arg Asp Ile Glu
                 420                 425                 430

 ata gga ttt ctt cca tgg cta atg aat gaa gtt gaa aaa acc atg gaa     1704
 Ile Gly Phe Leu Pro Trp Leu Met Asn Glu Val Glu Lys Thr Met Glu
             435                 440                 445

 tat agc atg gtg gga aga aca gtg ctt gac atg ttg atc cgt gag gtg     1752
 Tyr Ser Met Val Gly Arg Thr Val Leu Asp Met Leu Ile Arg Glu Val
         450                 455                 460

 gtt gaa aag agg ctg tgt atg tat gag cat ggg gaa gac aca cat cag     1800
 Val Glu Lys Arg Leu Cys Met Tyr Glu His Gly Glu Asp Thr His Gln
     465                 470                 475

 tct cca gaa ccc gag gat gag cct ggt ggt cct gga gca atg aca gag     1848
 Ser Pro Glu Pro Glu Asp Glu Pro Gly Gly Pro Gly Ala Met Thr Glu
 480                 485                 490                 495

 tca ctg gag gcc tct gaa ttc ctg gag cag agc atg tca cag aca cgg     1896
 Ser Leu Glu Ala Ser Glu Phe Leu Glu Gln Ser Met Ser Gln Thr Arg
                 500                 505                 510

 gag ctg ctt tta gat gga ggc tac cta caa aga aca aca tat gac aga     1944
 Glu Leu Leu Leu Asp Gly Gly Tyr Leu Gln Arg Thr Thr Tyr Asp Arg
             515                 520                 525

 agg tca tcc cag gaa agg aag ttt atg gaa gag aga gaa ctc tta ggg     1992
 Arg Ser Ser Gln Glu Arg Lys Phe Met Glu Glu Arg Glu Leu Leu Gly
         530                 535                 540

 caa gat gaa gaa aca gca atg agg aag tcc tta ggg gag gaa gaa ttg     2040
 Gln Asp Glu Glu Thr Ala Met Arg Lys Ser Leu Gly Glu Glu Glu Leu
     545                 550                 555

 tca tag gagggaagct tcaaagtcat gaaaccaatc aacagccaag tcagcaagca      2096
 Ser 
 560

 atcaggtaat gatgtgcgag tcccctcagg ttatagaaat tatgttgtat ttagtcagta   2156

 tgtctttttg tgtaatggac tgggccaatc aaatgtgata aaattaattt gagaatgaaa   2216

 cttaaattga attcatttat ttaatagaat attcaaaggc tatattgtaa ttctaatgag   2276

 aattatattt aattactagc tttctattac cattatatgt aaccagcaaa tatatttttc   2336

 cttagccctt ctaattttgc gggttagttt tttttagtaa gtatgatatt taatgttcaa   2396

 tatcagtgct gtcagccata tagcttttct tctctatagg aaaactattt cacctactgt   2456

 aag                                                                 2459




      <210> 168
      <211> 435
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (104)..(403)

      <400> 168
 gactctggcc tccctgcaga tcttctaaga accacactaa tgcaagcttg acagagaaac     60

 ctctttcgaa tgacttacta caactctggc attggttagt tcc  atg tat tgt aag     115
                                                  Met Tyr Cys Lys
                                                    1

 att ctg gtg cta atg ctc cat aca gaa ttg atc agg act gat tac tct      163
 Ile Leu Val Leu Met Leu His Thr Glu Leu Ile Arg Thr Asp Tyr Ser
   5                  10                  15                  20

 tct gtg gac caa ttg cta ttg aac tac cca gct gaa gag ggt ttg ggg      211
 Ser Val Asp Gln Leu Leu Leu Asn Tyr Pro Ala Glu Glu Gly Leu Gly
                  25                  30                  35

 aga gaa cgt tca tta tta tgg act cca ctt ttg tcc cct ggt agt tta      259
 Arg Glu Arg Ser Leu Leu Trp Thr Pro Leu Leu Ser Pro Gly Ser Leu
              40                  45                  50

 agg gtg ata cta gaa tcc aga gaa gtt cct gtc tcc ttg tgg cct caa      307
 Arg Val Ile Leu Glu Ser Arg Glu Val Pro Val Ser Leu Trp Pro Gln
          55                  60                  65

 aca ctc agg ccg tct caa aag ctt ttc acc aag gtg caa aat cat tta      355
 Thr Leu Arg Pro Ser Gln Lys Leu Phe Thr Lys Val Gln Asn His Leu
      70                  75                  80

 tct gca ttc cac aca tct ttt cca atg cat gga tcc aaa act ttt tag      403
 Ser Ala Phe His Thr Ser Phe Pro Met His Gly Ser Lys Thr Phe 
  85                  90                  95

 gtgggaggaa taaactaagt tggctacagg tt                                  435




      <210> 169
      <211> 479
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (195)..(428)

      <400> 169
 aaaaacagct catgtccata cacagaaaca gaaactgaac cgaacaccga aactgaaact     60

 gtttgtctct tcctgagaaa cgagcaaacc tgaaagctac tctctcagct tcagagggaa    120

 aaaatggttg tagatttctg gacttgggag cagacatttc aagaactaat ccaagaggca    180

 aaaccccggg ccac  atg gac gct gaa gtt gga tgg caa cct tca gct aga     230
                  Met Asp Ala Glu Val Gly Trp Gln Pro Ser Ala Arg
                    1               5                  10

 ctg cct ggc tca agg gtg gaa gca ata cca aca gag agc att tgg ctg      278
 Leu Pro Gly Ser Arg Val Glu Ala Ile Pro Thr Glu Ser Ile Trp Leu
          15                  20                  25

 gtt ccg gtg ttc ctc ctg cca gcg aag ttg ggc ttc cgc cca agt gca      326
 Val Pro Val Phe Leu Leu Pro Ala Lys Leu Gly Phe Arg Pro Ser Ala
      30                  35                  40

 gat tct gtg cca cac gta ctg gga gca ctg gac atc cca ggg tca ggt      374
 Asp Ser Val Pro His Val Leu Gly Ala Leu Asp Ile Pro Gly Ser Gly
  45                  50                  55                  60

 gcg tat gag gct ctt tgg cca aag gtg cca gaa gtg ctc ctg gtc cca      422
 Ala Tyr Glu Ala Leu Trp Pro Lys Val Pro Glu Val Leu Leu Val Pro
                  65                  70                  75

 ata tga gatgcctgag ttctcctcgg atagcaccat gaggattctg agcaacctgg       478
 Ile 


 t                                                                    479




      <210> 170
      <211> 1406
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (279)..(1367)

      <400> 170
 agggtggtcc agtttaaccc gttaacgttc gacacagtcg ttgtgggcct ggtgccaagc     60

 gtggttgtct atcccgtcta ctggcccatc ctctttctct ccggaatgtc ccggagcaag    120

 gtggctggga gccagagccc cacacctgcc gggcagcagg tgctggacgt cgacagctgc    180

 ctggactcaa cccgtgctgg acagctcctt cctcacgttc tgaggcctcc acgctgagca    240

 ggcctttgct ggacagatga agagtgactt gtttctgg    atg att cta aga gtg     293
                                              Met Ile Leu Arg Val
                                                1               5

 acc ttg agg aac cct ggg agc tca gga agg aag gag cgc cca gaa aca      341
 Thr Leu Arg Asn Pro Gly Ser Ser Gly Arg Lys Glu Arg Pro Glu Thr
                  10                  15                  20

 ggg aca ggg agc tgg ttg ggg agg acc aga aat cag gtt atc aat act      389
 Gly Thr Gly Ser Trp Leu Gly Arg Thr Arg Asn Gln Val Ile Asn Thr
              25                  30                  35

 ctg gct gac cat cgt cat cgt ggg act gac ttt ggt gga agt cct tgg      437
 Leu Ala Asp His Arg His Arg Gly Thr Asp Phe Gly Gly Ser Pro Trp
          40                  45                  50

 tta ctt atc att act gtg ttt ctg aga agt tat aaa ttt gcc atc tcc      485
 Leu Leu Ile Ile Thr Val Phe Leu Arg Ser Tyr Lys Phe Ala Ile Ser
      55                  60                  65

 ctc tgc aca agt tac ctt tgt gtg tct ttc ctg aag act atc ttc ccg      533
 Leu Cys Thr Ser Tyr Leu Cys Val Ser Phe Leu Lys Thr Ile Phe Pro
  70                  75                  80                  85

 tct caa aat gga cat gat gga tcc acg gat gta cag cag aga gcc agg      581
 Ser Gln Asn Gly His Asp Gly Ser Thr Asp Val Gln Gln Arg Ala Arg
                  90                  95                 100

 agg tcc aac tgc cgt aga cag gaa gga att aaa att gtc ctg gaa gac      629
 Arg Ser Asn Cys Arg Arg Gln Glu Gly Ile Lys Ile Val Leu Glu Asp
             105                 110                 115

 atc ttt act tta tgg aga cag gtg gaa acc aaa gtt cga gct aaa atc      677
 Ile Phe Thr Leu Trp Arg Gln Val Glu Thr Lys Val Arg Ala Lys Ile
         120                 125                 130

 cgt aag atg aag gtg aca aca aaa gtc aac cgt cat gac aaa atc aat      725
 Arg Lys Met Lys Val Thr Thr Lys Val Asn Arg His Asp Lys Ile Asn
     135                 140                 145

 gga aag agg aag acc gcc aaa gaa cat ctg agg aaa cta agc atg aaa      773
 Gly Lys Arg Lys Thr Ala Lys Glu His Leu Arg Lys Leu Ser Met Lys
 150                 155                 160                 165

 gaa cgt gag cac gga gaa aag gag agg cag gtg tca gag gca gag gaa      821
 Glu Arg Glu His Gly Glu Lys Glu Arg Gln Val Ser Glu Ala Glu Glu
                 170                 175                 180

 aat ggg aaa ttg gat atg aaa gaa ata cac acc tac atg gaa atg ttt      869
 Asn Gly Lys Leu Asp Met Lys Glu Ile His Thr Tyr Met Glu Met Phe
             185                 190                 195

 caa cgt gcg caa gcg ttg cgg cgg cgg gca gag gac tac tac aga tgc      917
 Gln Arg Ala Gln Ala Leu Arg Arg Arg Ala Glu Asp Tyr Tyr Arg Cys
         200                 205                 210

 aaa atc acc cct tct gca aga aag cct ctt tgc aac cgg gtc aga atg      965
 Lys Ile Thr Pro Ser Ala Arg Lys Pro Leu Cys Asn Arg Val Arg Met
     215                 220                 225

 gcg gca gtg gag cat cgt cat tct tca gga ttg ccc tac tgg ccc tac     1013
 Ala Ala Val Glu His Arg His Ser Ser Gly Leu Pro Tyr Trp Pro Tyr
 230                 235                 240                 245

 ctc aca gct gaa act tta aaa aac agg atg ggc cac cag cca cct cct     1061
 Leu Thr Ala Glu Thr Leu Lys Asn Arg Met Gly His Gln Pro Pro Pro
                 250                 255                 260

 cca act caa caa cat tct ata att gat aac tcc ctg agc ctc aag aca     1109
 Pro Thr Gln Gln His Ser Ile Ile Asp Asn Ser Leu Ser Leu Lys Thr
             265                 270                 275

 cct tcc gag tgt ctg ctc act ccc ctt cca ccc tca gct cta ccc tca     1157
 Pro Ser Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Leu Pro Ser
         280                 285                 290

 gcg gat gat aat ctc aag aca cct gcg gag tgt ctg ctc tat ccc ctt     1205
 Ala Asp Asp Asn Leu Lys Thr Pro Ala Glu Cys Leu Leu Tyr Pro Leu
     295                 300                 305

 cca ccc tca gcg gat gat aat ctc aag aca cct ccc gag tgt ctg ctc     1253
 Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys Leu Leu
 310                 315                 320                 325

 act ccc ctt cca ccc tca gct cca ccc tca gcg gat gat aat ctc aag     1301
 Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Leu Lys
                 330                 335                 340

 aca cct ccc gag tgt gtc tgc tca ctc ccc ttc cac cct cag cgg atg     1349
 Thr Pro Pro Glu Cys Val Cys Ser Leu Pro Phe His Pro Gln Arg Met
             345                 350                 355

 ata atc tca aga aac taa ggaaga ataaataaat aatataaaaa taaaaaaaaa     1403
 Ile Ile Ser Arg Asn 
         360

 aaa                                                                 1406




      <210> 171
      <211> 1463
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (279)..(1424)

      <400> 171
 agggtggtcc agtttaaccc gttaacgttc gacacagtcg ttgtgggcct ggtgccaagc     60

 gtggttgtct atcccgtcta ctggcccatc ctctttctct ccggaatgtc ccggagcaag    120

 gtggctggga gccagagccc cacacctgcc gggcagcagg tgctggacgt cgacagctgc    180

 ctggactcaa cccgtgctgg acagctcctt cctcacgttc tgaggcctcc acgctgagca    240

 ggcctttgct ggacagatga agagtgactt gtttctgg    atg att cta aga gtg     293
                                              Met Ile Leu Arg Val
                                                1               5

 acc ttg agg aac cct ggg agc tca gga agg aag gag cgc cca gaa aca      341
 Thr Leu Arg Asn Pro Gly Ser Ser Gly Arg Lys Glu Arg Pro Glu Thr
                  10                  15                  20

 ggg aca ggg agc tgg ttg ggg agg acc aga aat cag gtt atc aat act      389
 Gly Thr Gly Ser Trp Leu Gly Arg Thr Arg Asn Gln Val Ile Asn Thr
              25                  30                  35

 ctg gct gac cat cgt cat cgt ggg act gac ttt ggt gga agt cct tgg      437
 Leu Ala Asp His Arg His Arg Gly Thr Asp Phe Gly Gly Ser Pro Trp
          40                  45                  50

 tta ctt atc att act gtg ttt ctg aga agt tat aaa ttt gcc atc tcc      485
 Leu Leu Ile Ile Thr Val Phe Leu Arg Ser Tyr Lys Phe Ala Ile Ser
      55                  60                  65

 ctc tgc aca agt tac ctt tgt gtg tct ttc ctg aag act atc ttc ccg      533
 Leu Cys Thr Ser Tyr Leu Cys Val Ser Phe Leu Lys Thr Ile Phe Pro
  70                  75                  80                  85

 tct caa aat gga cat gat gga tcc acg gat gta cag cag aga gcc agg      581
 Ser Gln Asn Gly His Asp Gly Ser Thr Asp Val Gln Gln Arg Ala Arg
                  90                  95                 100

 agg tcc aac tgc cgt aga cag gaa gga att aaa att gtc ctg gaa gac      629
 Arg Ser Asn Cys Arg Arg Gln Glu Gly Ile Lys Ile Val Leu Glu Asp
             105                 110                 115

 atc ttt act tta tgg aga cag gtg gaa acc aaa gtt cga gct aaa atc      677
 Ile Phe Thr Leu Trp Arg Gln Val Glu Thr Lys Val Arg Ala Lys Ile
         120                 125                 130

 cgt aag atg aag gtg aca aca aaa gtc aac cgt cat gac aaa atc aat      725
 Arg Lys Met Lys Val Thr Thr Lys Val Asn Arg His Asp Lys Ile Asn
     135                 140                 145

 gga aag agg aag acc gcc aaa gaa cat ctg agg aaa cta agc atg aaa      773
 Gly Lys Arg Lys Thr Ala Lys Glu His Leu Arg Lys Leu Ser Met Lys
 150                 155                 160                 165

 gaa cgt gag cac gga gaa aag gag agg cag gtg tca gag gca gag gaa      821
 Glu Arg Glu His Gly Glu Lys Glu Arg Gln Val Ser Glu Ala Glu Glu
                 170                 175                 180

 aat ggg aaa ttg gat atg aaa gaa ata cac acc tac atg gaa atg ttt      869
 Asn Gly Lys Leu Asp Met Lys Glu Ile His Thr Tyr Met Glu Met Phe
             185                 190                 195

 caa cgt gcg caa gcg ttg cgg cgg cgg gca gag gac tac tac aga tgc      917
 Gln Arg Ala Gln Ala Leu Arg Arg Arg Ala Glu Asp Tyr Tyr Arg Cys
         200                 205                 210

 aaa atc acc cct tct gca aga aag cct ctt tgc aac cgg gtc aga atg      965
 Lys Ile Thr Pro Ser Ala Arg Lys Pro Leu Cys Asn Arg Val Arg Met
     215                 220                 225

 gcg gca gtg gag cat cgt cat tct tca gga ttg ccc tac tgg ccc tac     1013
 Ala Ala Val Glu His Arg His Ser Ser Gly Leu Pro Tyr Trp Pro Tyr
 230                 235                 240                 245

 ctc aca gct gaa act tta aaa aac agg atg ggc cac cag cca cct cct     1061
 Leu Thr Ala Glu Thr Leu Lys Asn Arg Met Gly His Gln Pro Pro Pro
                 250                 255                 260

 cca act caa caa cat tct ata att gat aac tcc ctg agc ctc aag aca     1109
 Pro Thr Gln Gln His Ser Ile Ile Asp Asn Ser Leu Ser Leu Lys Thr
             265                 270                 275

 cct tcc gag tgt gtg ctc tat ccc ctt cca ccc tca gcg gat gat aat     1157
 Pro Ser Glu Cys Val Leu Tyr Pro Leu Pro Pro Ser Ala Asp Asp Asn
         280                 285                 290

 ctc aag aca cct ccc gag tgt ctg ctc act ccc ctt cca ccc tca gct     1205
 Leu Lys Thr Pro Pro Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala
     295                 300                 305

 cta ccc tca gcg gat gat aat ctc aag aca cct gcg gag tgt ctg ctc     1253
 Leu Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ala Glu Cys Leu Leu
 310                 315                 320                 325

 tat ccc ctt cca ccc tca gcg gat gat aat ctc aag aca cct ccc gag     1301
 Tyr Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu
                 330                 335                 340

 tgt ctg ctc act ccc ctt cca ccc tca gct cca ccc tca gcg gat gat     1349
 Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp
             345                 350                 355

 aat ctc aag aca cct ccc gag tgt gtc tgc tca ctc ccc ttc cac cct     1397
 Asn Leu Lys Thr Pro Pro Glu Cys Val Cys Ser Leu Pro Phe His Pro
         360                 365                 370

 cag cgg atg ata atc tca aga aac taa ggaag aataaataaa taatataaaa     1449
 Gln Arg Met Ile Ile Ser Arg Asn 
     375                 380

 ataaaaaaaa aaaa                                                     1463




      <210> 172
      <211> 1337
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (279)..(1298)

      <400> 172
 agggtggtcc agtttaaccc gttaacgttc gacacagtcg ttgtgggcct ggtgccaagc     60

 gtggttgtct atcccgtcta ctggcccatc ctctttctct ccggaatgtc ccggagcaag    120

 gtggctggga gccagagccc cacacctgcc gggcagcagg tgctggacgt cgacagctgc    180

 ctggactcaa cccgtgctgg acagctcctt cctcacgttc tgaggcctcc acgctgagca    240

 ggcctttgct ggacagatga agagtgactt gtttctgg    atg att cta aga gtg     293
                                              Met Ile Leu Arg Val
                                                1               5

 acc ttg agg aac cct ggg agc tca gga agg aag gag cgc cca gaa aca      341
 Thr Leu Arg Asn Pro Gly Ser Ser Gly Arg Lys Glu Arg Pro Glu Thr
                  10                  15                  20

 ggg aca ggg agc tgg ttg ggg agg acc aga aat cag gtt atc aat act      389
 Gly Thr Gly Ser Trp Leu Gly Arg Thr Arg Asn Gln Val Ile Asn Thr
              25                  30                  35

 ctg gct gac cat cgt cat cgt ggg act gac ttt ggt gga agt cct tgg      437
 Leu Ala Asp His Arg His Arg Gly Thr Asp Phe Gly Gly Ser Pro Trp
          40                  45                  50

 tta ctt atc att act gtg ttt ctg aga agt tat aaa ttt gcc atc tcc      485
 Leu Leu Ile Ile Thr Val Phe Leu Arg Ser Tyr Lys Phe Ala Ile Ser
      55                  60                  65

 ctc tgc aca agt tac ctt tgt gtg tct ttc ctg aag act atc ttc ccg      533
 Leu Cys Thr Ser Tyr Leu Cys Val Ser Phe Leu Lys Thr Ile Phe Pro
  70                  75                  80                  85

 tct caa aat gga cat gat gga tcc acg gat gta cag cag aga gcc agg      581
 Ser Gln Asn Gly His Asp Gly Ser Thr Asp Val Gln Gln Arg Ala Arg
                  90                  95                 100

 agg tcc aac tgc cgt aga cag gaa gga att aaa att gtc ctg gaa gac      629
 Arg Ser Asn Cys Arg Arg Gln Glu Gly Ile Lys Ile Val Leu Glu Asp
             105                 110                 115

 atc ttt act tta tgg aga cag gtg gaa acc aaa gtt cga gct aaa atc      677
 Ile Phe Thr Leu Trp Arg Gln Val Glu Thr Lys Val Arg Ala Lys Ile
         120                 125                 130

 cgt aag atg aag gtg aca aca aaa gtc aac cgt cat gac aaa atc aat      725
 Arg Lys Met Lys Val Thr Thr Lys Val Asn Arg His Asp Lys Ile Asn
     135                 140                 145

 gga aag agg aag acc gcc aaa gaa cat ctg agg aaa cta agc atg aaa      773
 Gly Lys Arg Lys Thr Ala Lys Glu His Leu Arg Lys Leu Ser Met Lys
 150                 155                 160                 165

 gaa cgt gag cac gga gaa aag gag agg cag gtg tca gag gca gag gaa      821
 Glu Arg Glu His Gly Glu Lys Glu Arg Gln Val Ser Glu Ala Glu Glu
                 170                 175                 180

 aat ggg aaa ttg gat atg aaa gaa ata cac acc tac atg gaa atg ttt      869
 Asn Gly Lys Leu Asp Met Lys Glu Ile His Thr Tyr Met Glu Met Phe
             185                 190                 195

 caa cgt gcg caa gcg ttg cgg cgg cgg gca gag gac tac tac aga tgc      917
 Gln Arg Ala Gln Ala Leu Arg Arg Arg Ala Glu Asp Tyr Tyr Arg Cys
         200                 205                 210

 aaa atc acc cct tct gca aga aag cct ctt tgc aac cgg gtc aga atg      965
 Lys Ile Thr Pro Ser Ala Arg Lys Pro Leu Cys Asn Arg Val Arg Met
     215                 220                 225

 gcg gca gtg gag cat cgt cat tct tca gga ttg ccc tac tgg ccc tac     1013
 Ala Ala Val Glu His Arg His Ser Ser Gly Leu Pro Tyr Trp Pro Tyr
 230                 235                 240                 245

 ctc aca gct gaa act tta aaa aac agg atg ggc cac cag cca cct cct     1061
 Leu Thr Ala Glu Thr Leu Lys Asn Arg Met Gly His Gln Pro Pro Pro
                 250                 255                 260

 cca act caa caa cat tct ata att gat aac tcc ctg agc ctc aag aca     1109
 Pro Thr Gln Gln His Ser Ile Ile Asp Asn Ser Leu Ser Leu Lys Thr
             265                 270                 275

 cct gcg gag tgt ctg ctc tat ccc ctt cca ccc tca gcg gat gat aat     1157
 Pro Ala Glu Cys Leu Leu Tyr Pro Leu Pro Pro Ser Ala Asp Asp Asn
         280                 285                 290

 ctc aag aca cct ccc gag tgt ctg ctc act ccc ctt cca ccc tca gct     1205
 Leu Lys Thr Pro Pro Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala
     295                 300                 305

 cca ccc tca gcg gat gat aat ctc aag aca cct ccc gag tgt gtc tgc     1253
 Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys Val Cys
 310                 315                 320                 325

 tca ctc ccc ttc cac cct cag cgg atg ata atc tca aga aac taa gga     1301
 Ser Leu Pro Phe His Pro Gln Arg Met Ile Ile Ser Arg Asn 
                 330                 335

 agaataaata aataatataa aaataaaaaa aaaaaa                             1337




      <210> 173
      <211> 1298
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (279)..(1259)

      <400> 173
 agggtggtcc agtttaaccc gttaacgttc gacacagtcg ttgtgggcct ggtgccaagc     60

 gtggttgtct atcccgtcta ctggcccatc ctctttctct ccggaatgtc ccggagcaag    120

 gtggctggga gccagagccc cacacctgcc gggcagcagg tgctggacgt cgacagctgc    180

 ctggactcaa cccgtgctgg acagctcctt cctcacgttc tgaggcctcc acgctgagca    240

 ggcctttgct ggacagatga agagtgactt gtttctgg    atg att cta aga gtg     293
                                              Met Ile Leu Arg Val
                                                1               5

 acc ttg agg aac cct ggg agc tca gga agg aag gag cgc cca gaa aca      341
 Thr Leu Arg Asn Pro Gly Ser Ser Gly Arg Lys Glu Arg Pro Glu Thr
                  10                  15                  20

 ggg aca ggg agc tgg ttg ggg agg acc aga aat cag gtt atc aat act      389
 Gly Thr Gly Ser Trp Leu Gly Arg Thr Arg Asn Gln Val Ile Asn Thr
              25                  30                  35

 ctg gct gac cat cgt cat cgt ggg act gac ttt ggt gga agt cct tgg      437
 Leu Ala Asp His Arg His Arg Gly Thr Asp Phe Gly Gly Ser Pro Trp
          40                  45                  50

 tta ctt atc att act gtg ttt ctg aga agt tat aaa ttt gcc atc tcc      485
 Leu Leu Ile Ile Thr Val Phe Leu Arg Ser Tyr Lys Phe Ala Ile Ser
      55                  60                  65

 ctc tgc aca agt tac ctt tgt gtg tct ttc ctg aag act atc ttc ccg      533
 Leu Cys Thr Ser Tyr Leu Cys Val Ser Phe Leu Lys Thr Ile Phe Pro
  70                  75                  80                  85

 tct caa aat gga cat gat gga tcc acg gat gta cag cag aga gcc agg      581
 Ser Gln Asn Gly His Asp Gly Ser Thr Asp Val Gln Gln Arg Ala Arg
                  90                  95                 100

 agg tcc aac tgc cgt aga cag gaa gga att aaa att gtc ctg gaa gac      629
 Arg Ser Asn Cys Arg Arg Gln Glu Gly Ile Lys Ile Val Leu Glu Asp
             105                 110                 115

 atc ttt act tta tgg aga cag gtg gaa acc aaa gtt cga gct aaa atc      677
 Ile Phe Thr Leu Trp Arg Gln Val Glu Thr Lys Val Arg Ala Lys Ile
         120                 125                 130

 cgt aag atg aag gtg aca aca aaa gtc aac cgt cat gac aaa atc aat      725
 Arg Lys Met Lys Val Thr Thr Lys Val Asn Arg His Asp Lys Ile Asn
     135                 140                 145

 gga aag agg aag acc gcc aaa gaa cag gaa atg ttt caa cgt gcg caa      773
 Gly Lys Arg Lys Thr Ala Lys Glu Gln Glu Met Phe Gln Arg Ala Gln
 150                 155                 160                 165

 gcg ttg cgg cgg cgg gca gag gac tac tac aga tgc aaa atc acc cct      821
 Ala Leu Arg Arg Arg Ala Glu Asp Tyr Tyr Arg Cys Lys Ile Thr Pro
                 170                 175                 180

 tct gca aga aag cct ctt tgc aac cgg gtc aga atg gcg gca gtg gag      869
 Ser Ala Arg Lys Pro Leu Cys Asn Arg Val Arg Met Ala Ala Val Glu
             185                 190                 195

 cat cgt cat tct tca gga ttg ccc tac tgg ccc tac ctc aca gct gaa      917
 His Arg His Ser Ser Gly Leu Pro Tyr Trp Pro Tyr Leu Thr Ala Glu
         200                 205                 210

 act tta aaa aac agg atg ggc cac cag cca cct cct cca act caa caa      965
 Thr Leu Lys Asn Arg Met Gly His Gln Pro Pro Pro Pro Thr Gln Gln
     215                 220                 225

 cat tct ata att gat aac tcc ctg agc ctc aag aca cct tcc gag tgt     1013
 His Ser Ile Ile Asp Asn Ser Leu Ser Leu Lys Thr Pro Ser Glu Cys
 230                 235                 240                 245

 ctg ctc act ccc ctt cca ccc tca gct cta ccc tca gcg gat gat aat     1061
 Leu Leu Thr Pro Leu Pro Pro Ser Ala Leu Pro Ser Ala Asp Asp Asn
                 250                 255                 260

 ctc aag aca cct gcg gag tgt ctg ctc tat ccc ctt cca ccc tca gcg     1109
 Leu Lys Thr Pro Ala Glu Cys Leu Leu Tyr Pro Leu Pro Pro Ser Ala
             265                 270                 275

 gat gat aat ctc aag aca cct ccc gag tgt ctg ctc act ccc ctt cca     1157
 Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys Leu Leu Thr Pro Leu Pro
         280                 285                 290

 ccc tca gct cca ccc tca gcg gat gat aat ctc aag aca cct ccc gag     1205
 Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu
     295                 300                 305

 tgt gtc tgc tca ctc ccc ttc cac cct cag cgg atg ata atc tca aga     1253
 Cys Val Cys Ser Leu Pro Phe His Pro Gln Arg Met Ile Ile Ser Arg
 310                 315                 320                 325

 aac taa ggaagaataa ataaataata taaaaataaa aaaaaaaaa                  1298
 Asn 






      <210> 174
      <211> 977
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (245)..(574)

      <400> 174
 tattgtgctg agaggatcca agggattggt gggggaacag gcaagccagg catcaccgtg     60

 gatgttgaag aagggggtta ctcaaacctc ggcatcttca cttgctcgat ctggaattac    120

 agctatttat tacgaagcac tctgtgtggc ttagtggagt gtgtctgagg aaacacatcc    180

 cggacaccac ttagggttag tctttctgag ctcttcacat ctctgactaa ttatcatcat    240

 tacc atg gag ccc aac agt ccc aaa aag ata cag ttt gcc gtg cct gta     289
      Met Glu Pro Asn Ser Pro Lys Lys Ile Gln Phe Ala Val Pro Val
        1               5                  10                  15

 ttc cag agt cag att gca cct gaa gca gca gag cag atc agg aaa aga      337
 Phe Gln Ser Gln Ile Ala Pro Glu Ala Ala Glu Gln Ile Arg Lys Arg
                  20                  25                  30

 aga cct aca cca gca tca ctt gtg att ctc aat gag cat aac ccc cca      385
 Arg Pro Thr Pro Ala Ser Leu Val Ile Leu Asn Glu His Asn Pro Pro
              35                  40                  45

 gaa ata gat gac aag agg ggg ccc aac aca caa ggg gaa tta cag aat      433
 Glu Ile Asp Asp Lys Arg Gly Pro Asn Thr Gln Gly Glu Leu Gln Asn
          50                  55                  60

 gca tcc cct aag caa agg aag cag agt gtg tac aca cca ccc acc ata      481
 Ala Ser Pro Lys Gln Arg Lys Gln Ser Val Tyr Thr Pro Pro Thr Ile
      65                  70                  75

 aaa ggg gtt aag cat ctg aaa ggc cag aat gaa tca gca ttc cct gaa      529
 Lys Gly Val Lys His Leu Lys Gly Gln Asn Glu Ser Ala Phe Pro Glu
  80                  85                  90                  95

 gaa gaa gaa ggc acc aat gaa aga gag gag cag cgg gac cat taa tta      577
 Glu Glu Glu Gly Thr Asn Glu Arg Glu Glu Gln Arg Asp His 
                 100                 105

 ctggtctgca gcaagaaggc ttcttggaaa taactgaact attaactttt ctgagtatac    637

 catggaattc cactgcttga cttccagaag catcctccat ctctgcaccc cacactcata    697

 cagtagctat gcacatcctg gaagtctcct tgactgaact ttagaactaa gtacacattg    757

 ttccacatca cttataatta aagaataagc atttatttta cagtgattct tctttttaac    817

 tatgtaaaaa tttgcataca tgtgactgtt ctaactttaa tactgccaga gcttaatcct    877

 tgatgtccta ctgataaggt ttgcattcta acaacacatg taaataacat cactttaaga    937

 gtaaaaaata aatagtaaac acatttaaaa aaaaaaaaaa                          977




      <210> 175
      <211> 1895
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (415)..(1527)

      <400> 175
 gcaatttcct gctgcagaga gcattttaag aaaggacagc attcctgtga cctctgccta     60

 ccatccataa aatactcatc cccctctcag ctctgcctgc agttgaacac aaagacctgg    120

 aggagactcc cacctccttc agggagaaga aaggaggcag cgaagcagat taaaggaact    180

 tgtggcttgt ggcctttttg tgcaagggcc gcctggaagg ggagaaaagt gtatgaaagc    240

 caccgtggcg gttaatgagc tgtgagatga ggcgctgctg cggccgctgc tgctgacact    300

 cgctcccagg ctgcacccgc cgcccttggc gcttcatgta catgtgtcta ttcaggcctt    360

 gcggaggcgc ccagaagagc atccaacacg gctgccgggg aaagaccgcc cacc  atg     417
                                                              Met
                                                                1

 ccc acg gag acc cta cag aca ggt agc atg gtg aag ccg gtc agc ccc      465
 Pro Thr Glu Thr Leu Gln Thr Gly Ser Met Val Lys Pro Val Ser Pro
               5                  10                  15

 gcg ggc acc ttc acc tct gct gtg ccc ctg cgc atc ctg aac aag ggg      513
 Ala Gly Thr Phe Thr Ser Ala Val Pro Leu Arg Ile Leu Asn Lys Gly
          20                  25                  30

 cca gac tac ttc cgc agg cag gcc gag ccc aac ccc aag agg ctc agc      561
 Pro Asp Tyr Phe Arg Arg Gln Ala Glu Pro Asn Pro Lys Arg Leu Ser
      35                  40                  45

 gcc gtg gag agg ctg gag gcc gac aag gcc aag tac gtc aag agc cag      609
 Ala Val Glu Arg Leu Glu Ala Asp Lys Ala Lys Tyr Val Lys Ser Gln
  50                  55                  60                  65

 gag gtg atc aac gcc aag cag gag ccc gtg aag ccc gcc gtg ctg gcc      657
 Glu Val Ile Asn Ala Lys Gln Glu Pro Val Lys Pro Ala Val Leu Ala
                  70                  75                  80

 aag ccc ccg gtg tgc ccg gct gcc aag cgc gca ctg ggc agc ccc acg      705
 Lys Pro Pro Val Cys Pro Ala Ala Lys Arg Ala Leu Gly Ser Pro Thr
              85                  90                  95

 ctc aaa gtg ttc ggc aac cac gcc aag acc gag agc ggc gtg cag agg      753
 Leu Lys Val Phe Gly Asn His Ala Lys Thr Glu Ser Gly Val Gln Arg
         100                 105                 110

 gag aac ctg aag ctg gag atc ctg aag aac atc atc aat agc tcc gag      801
 Glu Asn Leu Lys Leu Glu Ile Leu Lys Asn Ile Ile Asn Ser Ser Glu
     115                 120                 125

 ggc tct agc tcg ggc tcg ggg cac aag cac agc tcc cgc aac tgg ccg      849
 Gly Ser Ser Ser Gly Ser Gly His Lys His Ser Ser Arg Asn Trp Pro
 130                 135                 140                 145

 ccc cac cgg tcg gaa gcc act gac ctg cac cgt cac tcc ttc gcg gag      897
 Pro His Arg Ser Glu Ala Thr Asp Leu His Arg His Ser Phe Ala Glu
                 150                 155                 160

 tcc ctg aag gtc tac ccc acg cag ggc cgc agg agc ccg cag gag ggc      945
 Ser Leu Lys Val Tyr Pro Thr Gln Gly Arg Arg Ser Pro Gln Glu Gly
             165                 170                 175

 ggc tcc cac gtg ggc agg aga ctg ctg gag cag tca gcc gag tcc ttc      993
 Gly Ser His Val Gly Arg Arg Leu Leu Glu Gln Ser Ala Glu Ser Phe
         180                 185                 190

 ctc cac gtg tcc cac agc tct tcg gac atc cgc aag gtg acc agc gtg     1041
 Leu His Val Ser His Ser Ser Ser Asp Ile Arg Lys Val Thr Ser Val
     195                 200                 205

 aag ccc ctc aag gcc atc ccc tgc agt agc tct gcc cct ccc ctg cct     1089
 Lys Pro Leu Lys Ala Ile Pro Cys Ser Ser Ser Ala Pro Pro Leu Pro
 210                 215                 220                 225

 ccc aag ccc aaa atc gca gcc atc gcc tcc atg aag tcc ccc gag gcc     1137
 Pro Lys Pro Lys Ile Ala Ala Ile Ala Ser Met Lys Ser Pro Glu Ala
                 230                 235                 240

 gac cct gtg gaa cca gct tgt gga gtc agc cga aga ccc tcc ctc cag     1185
 Asp Pro Val Glu Pro Ala Cys Gly Val Ser Arg Arg Pro Ser Leu Gln
             245                 250                 255

 cgg tct aag tca gac ttg agt gac aga tat ttc cga gtg gac gcg gac     1233
 Arg Ser Lys Ser Asp Leu Ser Asp Arg Tyr Phe Arg Val Asp Ala Asp
         260                 265                 270

 gtg gag agg ttc ttc aac tac tgt gga ctg gac ccg gaa gag ctg gaa     1281
 Val Glu Arg Phe Phe Asn Tyr Cys Gly Leu Asp Pro Glu Glu Leu Glu
     275                 280                 285

 aac ctg gga atg gaa aac ttt gca agg gct aat tct gac ata ata tcc     1329
 Asn Leu Gly Met Glu Asn Phe Ala Arg Ala Asn Ser Asp Ile Ile Ser
 290                 295                 300                 305

 ctc aac ttc cgc agc gca agc atg atc agc tca gac tgt gaa cag tct     1377
 Leu Asn Phe Arg Ser Ala Ser Met Ile Ser Ser Asp Cys Glu Gln Ser
                 310                 315                 320

 cag gac agt aac agt gac ctt aga aat gat gac agt gcc aat gac cgc     1425
 Gln Asp Ser Asn Ser Asp Leu Arg Asn Asp Asp Ser Ala Asn Asp Arg
             325                 330                 335

 gtg ccg tat ggc att tct gcc atc gaa aga aat gct aga atc atc aag     1473
 Val Pro Tyr Gly Ile Ser Ala Ile Glu Arg Asn Ala Arg Ile Ile Lys
         340                 345                 350

 tgg tta tat agc atc aaa caa gct aga gag tca cag aag gtc tcc cat     1521
 Trp Leu Tyr Ser Ile Lys Gln Ala Arg Glu Ser Gln Lys Val Ser His
     355                 360                 365

 gtg taa gacagtgcgt ggaaaggagg gagcgtgggt ctctgtgctt acgcagttgt      1577
 Val 
 370

 gaaggttgtg aggtctcctt gaagtgttgt gagcttctcc actctttgtg ttgcttgttg   1637

 tgcaatgttt tcaagttgca tgcttgtcaa catggggact gacctggctt ccacgtcacc   1697

 atcgctacag agcctggctg aacacgcgtc atctgccaaa agtttcaggc cagaatctaa   1757

 ttagggcttt gctcgtaagc aaaactgttt acatgaaaat ggtatacaac ttcttcgata   1817

 tttatgtggt tcttgtgttt ttatatcccg cgctattgtg tcttaattaa aagttttatc   1877

 aactggcaaa aaaaaaaa                                                 1895




      <210> 176
      <211> 1281
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (326)..(949)

      <400> 176
 ctccgtgact gaggttctga cctgctgttg atgtgctata cctccttcaa ttctcagctc     60

 tcaaagggga aaacaactgc agaggatggg aaatgctata ctgccatgcc tggaaacacc    120

 cacaggaaaa ttaccagttt tgagcttgct caactgcaag aaaaactgaa ggagacaaaa    180

 gcagccatgg aaaaattaat caacagagtg gaacctaatg gtgaaaggat aagggcttct    240

 gatttcccat gacttaggaa acagaattaa aactgtttca ttcattgaaa atcaaaatgc    300

 cctgcgtaca gtctggaaaa gtaac  atg tgc cgc ctg aag aga caa gag ttt     352
                              Met Cys Arg Leu Lys Arg Gln Glu Phe
                                1               5

 gtg ata agc aga gca cag act gtg act tct gac caa gag aaa cgg ttg      400
 Val Ile Ser Arg Ala Gln Thr Val Thr Ser Asp Gln Glu Lys Arg Leu
  10                  15                  20                  25

 cta cat cag ctc cga gaa atc acc agg gtc atg aaa gaa gga aaa ttc      448
 Leu His Gln Leu Arg Glu Ile Thr Arg Val Met Lys Glu Gly Lys Phe
                  30                  35                  40

 att gac aga ttt tct cca gag aaa gaa gct gag gag gcc cct tac atg      496
 Ile Asp Arg Phe Ser Pro Glu Lys Glu Ala Glu Glu Ala Pro Tyr Met
              45                  50                  55

 gag gac tgg gaa ggt tac cct gaa gag act tac cca att tat gac ctt      544
 Glu Asp Trp Glu Gly Tyr Pro Glu Glu Thr Tyr Pro Ile Tyr Asp Leu
          60                  65                  70

 tca gac tgt atc aag cgt agg caa gaa aca atc ttg gtg gat tac cct      592
 Ser Asp Cys Ile Lys Arg Arg Gln Glu Thr Ile Leu Val Asp Tyr Pro
      75                  80                  85

 gac cca aaa gaa ctt tct gct gaa gaa ata gct gaa aga atg gga atg      640
 Asp Pro Lys Glu Leu Ser Ala Glu Glu Ile Ala Glu Arg Met Gly Met
  90                  95                 100                 105

 ata gaa gag gaa gaa tca gat cat ttg ggt tgg gaa agt ctg ccc act      688
 Ile Glu Glu Glu Glu Ser Asp His Leu Gly Trp Glu Ser Leu Pro Thr
                 110                 115                 120

 gac ccc aga gcc cag gaa gat aat tct gtt acc tcg tgt gat cca aag      736
 Asp Pro Arg Ala Gln Glu Asp Asn Ser Val Thr Ser Cys Asp Pro Lys
             125                 130                 135

 cca gaa aca tgt tcc tgc tgt ttt cat gaa gac gag gat cct gct gtc      784
 Pro Glu Thr Cys Ser Cys Cys Phe His Glu Asp Glu Asp Pro Ala Val
         140                 145                 150

 ttg gca gag aat gct gga ttc agt gca gat agc tac cct gag caa gag      832
 Leu Ala Glu Asn Ala Gly Phe Ser Ala Asp Ser Tyr Pro Glu Gln Glu
     155                 160                 165

 gaa acc acc aaa gaa gag tgg tcc caa gac ttt aaa gat gaa ggg ttg      880
 Glu Thr Thr Lys Glu Glu Trp Ser Gln Asp Phe Lys Asp Glu Gly Leu
 170                 175                 180                 185

 ggc atc agc acc gat aaa gca tat aca ggc agc atg ctg agg aag cgt      928
 Gly Ile Ser Thr Asp Lys Ala Tyr Thr Gly Ser Met Leu Arg Lys Arg
                 190                 195                 200

 aac ccc cag ggt tta gag tga aa acagccagtc tgaagtatcc attactcaag      981
 Asn Pro Gln Gly Leu Glu 
             205

 tcccaagatg ggaccactca ggggcaaagg tctgactctt cctggtaggt gtaacagata   1041

 gttcacctgt gaacgaacat cagcttacag atgatgagga cttaaggttg caagaatgaa   1101

 gatttcagac tccaagatcc cttattcttt gggccttgag cagaatatcc tgtatgcgct   1161

 atttcccacc agaggcagag gccacaggag ataggccatg gttcaggtag gaaatgctct   1221

 tggtcacatc agaactctag atctggggga ataaacaaac ccgaattatt aaaaaaaaaa   1281




      <210> 177
      <211> 1345
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (394)..(678)

      <400> 177
 tcggggactt ctgcggcctg aagatcgaac aaaagatgtc ctgaccaagc caaggaccaa     60

 ccgctttgtg aaattggcag tgatggggct gacagtggca cttggagcgg ctgcactggc    120

 tgtggtgaaa agtgccctgg aatgggcccc taagtttcag ctgcagctgt ttccctgaaa    180

 gccagagaag accttcctct tacatcacat taaggtctca cccttccatg gaaggattgg    240

 gaggggtgga atttccttta ttaaaagggt ttctgtccag agttttttat tcctgccacc    300

 ctgccctgcc cgtttgtgtt tgcctttact tcagaggcca atagcagagc ctacctgaca    360

 cagaggggac ctgggggcct ggcacagaat ctt atg cct ctc cca gtg ggc ttt     414
                                      Met Pro Leu Pro Val Gly Phe
                                        1               5

 tgg atg ggc tct ctg cca cct ccc tgg tgt tgg agg aag tgg gtt tct      462
 Trp Met Gly Ser Leu Pro Pro Pro Trp Cys Trp Arg Lys Trp Val Ser
          10                  15                  20

 gaa gct tgc agc tgc ttt tgc aac ctg ctg ggc ctg ggc tgc cct agt      510
 Glu Ala Cys Ser Cys Phe Cys Asn Leu Leu Gly Leu Gly Cys Pro Ser
      25                  30                  35

 tac cgg gaa cct cct agt cac ccc ata gaa ggt gaa ctg gaa cat ggg      558
 Tyr Arg Glu Pro Pro Ser His Pro Ile Glu Gly Glu Leu Glu His Gly
  40                  45                  50                  55

 atg ccc tct tac tgc tcc tgc ttg cct gca tca gat gga cac aga agg      606
 Met Pro Ser Tyr Cys Ser Cys Leu Pro Ala Ser Asp Gly His Arg Arg
                  60                  65                  70

 agg ggg ctg ctg ctg aag gag tca ggc ttg gga tgg aga gca aga ggc      654
 Arg Gly Leu Leu Leu Lys Glu Ser Gly Leu Gly Trp Arg Ala Arg Gly
              75                  80                  85

 caa agg act cgt ctg gga gca tga tcggcccctc ttactagcag ctccatcagc     708
 Gln Arg Thr Arg Leu Gly Ala 
          90

 tgatcagaaa tcagagacag aagggaacta ggttactcgt taaatcctac ctattttcag    768

 cctagaaatc acatgggcgt ttccagtcaa gtgggaagga agctcatttt tagggcctag    828

 acctagacta gttttgcctg cctttttttc ctccctgctt tcttctacaa gccacacaac    888

 attgcttata aaaggtactt ttattactat ttttagaata tatacacccc atatgtaaat    948

 taccctcact tttaaagtaa taatagttcc ttcacggaaa aaaaaatagt tctcatcaga   1008

 aggatgagct tctaagatcc tgaattttga ctttctactt tgattaacat tttcgcttta   1068

 gccagagttg gtattttgca aacagttttc acttccaaag tgccactttt ctggacgggt   1128

 ttttcttttc ctgtgctccc tcaaaatcat gctaactccc aaatatggcc cactcacgta   1188

 ccttgggggt cagtataggg tctgagcttg atcgccaata gctggttctt cccctggtgg   1248

 cattgttctg ggacttcgaa attttccgac cttgggaaga gggcaacacg ctctggaagt   1308

 ccggagaaac cgggtgttat ccctgggaga aaagtct                            1345




      <210> 178
      <211> 1259
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (193)..(1113)

      <400> 178
 tttcgtgctt tggagccgca aagtttggct gtggcggtaa atgggcttgg gcggctcctc     60

 ggcgggtggc ggtggtggcc gtagcggttc ctcctggccc tgttaatgtc ggggccaggc    120

 cgggggagga tggcgcccta gaacccggcc ttgctggggt aggggcggga ggggacgggg    180

 tggggaccgg cc    atg tcg gag gtg acc cgg agt ctg ctg cag cgc tgg     228
                  Met Ser Glu Val Thr Arg Ser Leu Leu Gln Arg Trp
                    1               5                  10

 ggc gcc agt ttt agg aga ggc gcc gac ttc gac tct tgg ggc cag ctg      276
 Gly Ala Ser Phe Arg Arg Gly Ala Asp Phe Asp Ser Trp Gly Gln Leu
          15                  20                  25

 gtg gag gcg ata gac gag tat cag ata tta gca aga cat cta caa aag      324
 Val Glu Ala Ile Asp Glu Tyr Gln Ile Leu Ala Arg His Leu Gln Lys
      30                  35                  40

 gag gcc caa gct caa cac aat aat tct gaa ttc aca gaa gaa caa aag      372
 Glu Ala Gln Ala Gln His Asn Asn Ser Glu Phe Thr Glu Glu Gln Lys
  45                  50                  55                  60

 aaa acc ata ggc aaa att gca aca tgc ttg gaa ttg cga agt gca gct      420
 Lys Thr Ile Gly Lys Ile Ala Thr Cys Leu Glu Leu Arg Ser Ala Ala
                  65                  70                  75

 tta cag tcc aca cag tct caa gaa gaa ttt aaa ctg gag gac ctg aag      468
 Leu Gln Ser Thr Gln Ser Gln Glu Glu Phe Lys Leu Glu Asp Leu Lys
              80                  85                  90

 aag cta gaa cca atc cta aag aat att ctt aca tat aat aaa gaa ttc      516
 Lys Leu Glu Pro Ile Leu Lys Asn Ile Leu Thr Tyr Asn Lys Glu Phe
          95                 100                 105

 cca ttt gat gtt cag cct gtc cca tta aga aga att ttg gca cct ggt      564
 Pro Phe Asp Val Gln Pro Val Pro Leu Arg Arg Ile Leu Ala Pro Gly
     110                 115                 120

 gaa gaa gag aat ttg gaa ttt gaa gaa gat gaa gaa gag ggt ggt gct      612
 Glu Glu Glu Asn Leu Glu Phe Glu Glu Asp Glu Glu Glu Gly Gly Ala
 125                 130                 135                 140

 gga gca ggg tct cct gat tct ttt cct gct aga gtt ccc ggt act tta      660
 Gly Ala Gly Ser Pro Asp Ser Phe Pro Ala Arg Val Pro Gly Thr Leu
                 145                 150                 155

 tta cca agg ttg cca tcg gaa cca gga atg aca tta ctc act atc aga      708
 Leu Pro Arg Leu Pro Ser Glu Pro Gly Met Thr Leu Leu Thr Ile Arg
             160                 165                 170

 att gag aaa att ggt ttg aaa gat gct ggg cag tgc atc aat ccc tat      756
 Ile Glu Lys Ile Gly Leu Lys Asp Ala Gly Gln Cys Ile Asn Pro Tyr
         175                 180                 185

 att aca gtt agt gta aag gat ctg aat ggc ata gac tta act cct gtg      804
 Ile Thr Val Ser Val Lys Asp Leu Asn Gly Ile Asp Leu Thr Pro Val
     190                 195                 200

 caa gat act cct gtg gct tca aga aaa gaa gat aca tat gtt cat ttt      852
 Gln Asp Thr Pro Val Ala Ser Arg Lys Glu Asp Thr Tyr Val His Phe
 205                 210                 215                 220

 aat gtg gac att gag ctc cag aag cat gtt gaa aaa tta acc aaa ggt      900
 Asn Val Asp Ile Glu Leu Gln Lys His Val Glu Lys Leu Thr Lys Gly
                 225                 230                 235

 gca gct atc ttc ttt gaa ttc aaa cac tac aag cct aaa aaa agg ttt      948
 Ala Ala Ile Phe Phe Glu Phe Lys His Tyr Lys Pro Lys Lys Arg Phe
             240                 245                 250

 acc agc acc aag tgt ttt gct ttc atg gag atg gat gaa att aaa cct      996
 Thr Ser Thr Lys Cys Phe Ala Phe Met Glu Met Asp Glu Ile Lys Pro
         255                 260                 265

 ggg cca att gta ata gaa cta tac aag aaa ccc act gac ttt aaa aga     1044
 Gly Pro Ile Val Ile Glu Leu Tyr Lys Lys Pro Thr Asp Phe Lys Arg
     270                 275                 280

 aag aaa ttg caa tta ttg acc aag aaa cca ctt tat ctt cat cta cat     1092
 Lys Lys Leu Gln Leu Leu Thr Lys Lys Pro Leu Tyr Leu His Leu His
 285                 290                 295                 300

 caa act ttg cac aag gaa tga tc ctgacatgat gaacctggaa cttctgtgaa     1145
 Gln Thr Leu His Lys Glu 
                 305

 ttttaccact cagtagaaac catcatagct ctgtgtagca tattcaccct tcaacaggca   1205

 ggaagcaagc cgtacccaga ccagtaggcc ggacggagtc caatgcaaag ctgt         1259




      <210> 179
      <211> 400
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(349)

      <400> 179
 tgtataataa atcaggtttc attgttatat tatttaccac  atg aat cac ctt cct      55
                                              Met Asn His Leu Pro
                                                1               5

 cct aac cat tat agg agc cat gtg ttc aca tgt cat gtg gac cag tat      103
 Pro Asn His Tyr Arg Ser His Val Phe Thr Cys His Val Asp Gln Tyr
                  10                  15                  20

 tta act gtg gaa acc gcg ggt ggc atg gag aag gag gca gtg tcc gtg      151
 Leu Thr Val Glu Thr Ala Gly Gly Met Glu Lys Glu Ala Val Ser Val
              25                  30                  35

 act gtg ctg ctc tcc gca gcc ccc tgc ctg ctg tcc tgt ttc ctc ggc      199
 Thr Val Leu Leu Ser Ala Ala Pro Cys Leu Leu Ser Cys Phe Leu Gly
          40                  45                  50

 tcc tcg gtg tct gga ctg gcg ttc tgg gtt tcc cag cag aaa act aaa      247
 Ser Ser Val Ser Gly Leu Ala Phe Trp Val Ser Gln Gln Lys Thr Lys
      55                  60                  65

 ggg cca gag agg tgt aaa aac aca cac cac ttg gca ggt gat ttg aag      295
 Gly Pro Glu Arg Cys Lys Asn Thr His His Leu Ala Gly Asp Leu Lys
  70                  75                  80                  85

 ata tta aag cta gaa att gga act aga aaa tca aaa gaa ttc aag gca      343
 Ile Leu Lys Leu Glu Ile Gly Thr Arg Lys Ser Lys Glu Phe Lys Ala
                  90                  95                 100

 tct taa cgtgacagtt gaactcattt gattatactt aaaaaagttt tcagtgatag       399
 Ser 


 t                                                                    400




      <210> 180
      <211> 1742
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (104)..(484)

      <400> 180
 cacacacaga aaaacaaaaa gaatctttgt tttaccccga aagagaggca gaggcagaaa     60

 gtcttcttct gctttttgca tctctaagag gctgaaaaag aga  atg gaa gtg ctg     115
                                                  Met Glu Val Leu
                                                    1

 ggg cat ttt ggc cag ggc agt aat gga tat ttg gag ttg gca ctt ccc      163
 Gly His Phe Gly Gln Gly Ser Asn Gly Tyr Leu Glu Leu Ala Leu Pro
   5                  10                  15                  20

 tca gct aga gga gtc tca gtg tgt ctg aga aaa tgg cag tca gcc atc      211
 Ser Ala Arg Gly Val Ser Val Cys Leu Arg Lys Trp Gln Ser Ala Ile
                  25                  30                  35

 cag gat ttt agg agc aac gcc act gct ctg tgc cac atc aga aat cag      259
 Gln Asp Phe Arg Ser Asn Ala Thr Ala Leu Cys His Ile Arg Asn Gln
              40                  45                  50

 gca tgg ccc caa cct gaa gga act tgt agc tta atg ggg aag cac acc      307
 Ala Trp Pro Gln Pro Glu Gly Thr Cys Ser Leu Met Gly Lys His Thr
          55                  60                  65

 aag aat aaa aga gcc tcc aga aca tgt ggt gcc tgt ggt cct gag aca      355
 Lys Asn Lys Arg Ala Ser Arg Thr Cys Gly Ala Cys Gly Pro Glu Thr
      70                  75                  80

 gca gga aat ggc tct cag gcc aga gtt gct gga aga acc cat gtg gca      403
 Ala Gly Asn Gly Ser Gln Ala Arg Val Ala Gly Arg Thr His Val Ala
  85                  90                  95                 100

 gga tcg gtg gga ggc agt tac aga ggg aaa cgc cca tcc cag caa cta      451
 Gly Ser Val Gly Gly Ser Tyr Arg Gly Lys Arg Pro Ser Gln Gln Leu
                 105                 110                 115

 ggg gag gcc gcc act ctt ctc gtg gat gga tga tattcttg cttggggatg      502
 Gly Glu Ala Ala Thr Leu Leu Val Asp Gly 
             120                 125

 ttgagacagc tgcactctgc atagttcctg atttgcctct ctactgctga tgaaaaacct    562

 ttctttctct atagctgctg cttatattgg aaggcttttg gttattcagc acactcactc    622

 ctgagcttat ttcagtgata ttccttggtt atttcgaaac atggatgctt gtggcagatg    682

 gagagcctgg gtgtacacag atctgcctgt gttttgaaat gcataccatg ttgccgtttg    742

 tttgattgat tgatcttgga ccacgaaaga aaattatact gacagcttcc agggtagggg    802

 gcagttgtag ctttctgcag atgttgccaa atatattggg ggtggggagc agcaaatgcc    862

 atgtgttgct ttttatgaca taaggaggga ttccaccccc atcccaataa aatcggtgct    922

 ttgacaaagg agggttccca ggcagctaag agaacccaga gtagatgatc ctctttatct    982

 ctggtttaac ctgtgactag gattcttggt gtaagctcgg cttttccact tatcctctaa   1042

 ccggaacagg cttctataat ctctttgcct taaaataatt atctgcatcc ctgtgtagag   1102

 caatcttaag cagctctcct tgtttcttca gggaatggga attcttttct aagtcgcccc   1162

 atcaaaggta ctattggttt tttacaacgc cggcgtttgt gtatgtagta aaagtattaa   1222

 cagcattaaa ggcgatattt ttaacatgtt tatagatact acttggggga gggcagctaa   1282

 tgaaaccttc aagctctatg cagtccacag acgtgagctc tgtagagttc gcagaggtgg   1342

 gtaagtaccc agccagcaca cccagttgaa ttcagccagg atttattgag ttggcatcac   1402

 agacgctgac agcctccaag tgaaaaccct tctcttgaat atgtacaggt ttcccatcca   1462

 cataccaagc tgatgaggat cccatcgttc ttccccagtc ctgaggagcc cccctcgcca   1522

 tctgcacctt ccatagccaa atcagggtca ttggactcag aactttcagt gtccccaaaa   1582

 aggaacagca tctctcggac acacaaagat aaggggcctt ttcacatact gagttcaacc   1642

 agccagacaa acaaaggacc agaagggcag agccaggccc ctgcgtccac ctctgcctct   1702

 acccgcctgt ttgggttaac aaagccaaag gaaaagaagg                         1742




      <210> 181
      <211> 3641
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (116)..(3064)

      <400> 181
 tttcgtccgc cgcggaccat gagctgagta agttctggag ggatcctgcc tcttggagcc     60

 ttcgcagcca ggcagctgtg aactgtgagc tagagtgaag cagaaatcta ggaag atg     118
                                                              Met
                                                                1

 agc tcc aag atg gtc ata agt gaa cca gga ctg aat tgg gat att tcc      166
 Ser Ser Lys Met Val Ile Ser Glu Pro Gly Leu Asn Trp Asp Ile Ser
               5                  10                  15

 ccc aaa aat ggc ctt aag aca ttt ttc tct cga gaa aat tat aaa gat      214
 Pro Lys Asn Gly Leu Lys Thr Phe Phe Ser Arg Glu Asn Tyr Lys Asp
          20                  25                  30

 cat tcc atg gct cca agt tta aaa gaa cta cgt gtt tta tcc aac aga      262
 His Ser Met Ala Pro Ser Leu Lys Glu Leu Arg Val Leu Ser Asn Arg
      35                  40                  45

 cgt ata gga gaa aat ttg aat gcc tca gca agt tct gta gaa aat gag      310
 Arg Ile Gly Glu Asn Leu Asn Ala Ser Ala Ser Ser Val Glu Asn Glu
  50                  55                  60                  65

 ccg gca gtt agt tca gca act caa gca aag gaa aaa gtt aaa acc aca      358
 Pro Ala Val Ser Ser Ala Thr Gln Ala Lys Glu Lys Val Lys Thr Thr
                  70                  75                  80

 att gga atg gtt ctt ctt cca aaa cca aga gtt cct tat cct cgt ttc      406
 Ile Gly Met Val Leu Leu Pro Lys Pro Arg Val Pro Tyr Pro Arg Phe
              85                  90                  95

 tct cgt ttc tca cag aga gag cag agg agt tat gtg gac ttg ttg gtt      454
 Ser Arg Phe Ser Gln Arg Glu Gln Arg Ser Tyr Val Asp Leu Leu Val
         100                 105                 110

 aaa tac gca aag att cct gca aat tcc aaa gct gtt gga ata aat aaa      502
 Lys Tyr Ala Lys Ile Pro Ala Asn Ser Lys Ala Val Gly Ile Asn Lys
     115                 120                 125

 aat gac tac ttg cag tac ttg gat atg aaa aaa cat gtg aac gaa gaa      550
 Asn Asp Tyr Leu Gln Tyr Leu Asp Met Lys Lys His Val Asn Glu Glu
 130                 135                 140                 145

 gtt act gag ttc cta aag ttt ttg cag aat tct gca aag aaa tgt gcg      598
 Val Thr Glu Phe Leu Lys Phe Leu Gln Asn Ser Ala Lys Lys Cys Ala
                 150                 155                 160

 cag gat tat aat atg ctt tct gat gat gcc cgt ctc ttc aca gag aaa      646
 Gln Asp Tyr Asn Met Leu Ser Asp Asp Ala Arg Leu Phe Thr Glu Lys
             165                 170                 175

 att tta aga gct tgc att gaa caa gtg aaa aag tat tca gaa ttc tat      694
 Ile Leu Arg Ala Cys Ile Glu Gln Val Lys Lys Tyr Ser Glu Phe Tyr
         180                 185                 190

 act ctc cac gag gtc acc agc tta atg gga ttc ttc cca ttc aga gta      742
 Thr Leu His Glu Val Thr Ser Leu Met Gly Phe Phe Pro Phe Arg Val
     195                 200                 205

 gag atg gga tta aag tta gaa aaa act ctt ctc gca ttg ggc agt gta      790
 Glu Met Gly Leu Lys Leu Glu Lys Thr Leu Leu Ala Leu Gly Ser Val
 210                 215                 220                 225

 aaa tat gtg aaa aca gta ttt ccc tca atg cct ata aag ttg cag ctg      838
 Lys Tyr Val Lys Thr Val Phe Pro Ser Met Pro Ile Lys Leu Gln Leu
                 230                 235                 240

 tca aag gac gat ata gct acc att gaa acg tca gaa caa aca gct gaa      886
 Ser Lys Asp Asp Ile Ala Thr Ile Glu Thr Ser Glu Gln Thr Ala Glu
             245                 250                 255

 gct atg cat tat gat att agt aaa gat cca aat gca gag aag ctt gtt      934
 Ala Met His Tyr Asp Ile Ser Lys Asp Pro Asn Ala Glu Lys Leu Val
         260                 265                 270

 tcc aga tat cac cct cag ata gct cta act agt cag tca tta ttt acc      982
 Ser Arg Tyr His Pro Gln Ile Ala Leu Thr Ser Gln Ser Leu Phe Thr
     275                 280                 285

 tta tta aat aat cat gga cca acg tac aag gaa cag tgg gaa att cca     1030
 Leu Leu Asn Asn His Gly Pro Thr Tyr Lys Glu Gln Trp Glu Ile Pro
 290                 295                 300                 305

 gtg tgt att caa gta ata cct gtt gca ggt tca aaa cca gtt aaa gta     1078
 Val Cys Ile Gln Val Ile Pro Val Ala Gly Ser Lys Pro Val Lys Val
                 310                 315                 320

 ata tat att aat tca cca ctt ccc caa aag aaa atg act atg aga gag     1126
 Ile Tyr Ile Asn Ser Pro Leu Pro Gln Lys Lys Met Thr Met Arg Glu
             325                 330                 335

 aga aat caa atc ttt cat gaa gtt cca tta aaa ttt atg atg tcc aaa     1174
 Arg Asn Gln Ile Phe His Glu Val Pro Leu Lys Phe Met Met Ser Lys
         340                 345                 350

 aac aca tct gtt cca gtc tct gca gtc ttt atg gac aaa cct gaa gag     1222
 Asn Thr Ser Val Pro Val Ser Ala Val Phe Met Asp Lys Pro Glu Glu
     355                 360                 365

 ttt ata tct gaa atg gac atg tcc tgt gaa gtc aac gag tgc cga aaa     1270
 Phe Ile Ser Glu Met Asp Met Ser Cys Glu Val Asn Glu Cys Arg Lys
 370                 375                 380                 385

 att gag agt ctt gaa aac ttg tat ttg gat ttt gat gat gat gtc aca     1318
 Ile Glu Ser Leu Glu Asn Leu Tyr Leu Asp Phe Asp Asp Asp Val Thr
                 390                 395                 400

 gaa ctt gaa act ttt gga gta acc acc acc aaa gta tca aaa tca cca     1366
 Glu Leu Glu Thr Phe Gly Val Thr Thr Thr Lys Val Ser Lys Ser Pro
             405                 410                 415

 agt cca gca agt act tcc aca gta cct aac atg aca gat gct cct aca     1414
 Ser Pro Ala Ser Thr Ser Thr Val Pro Asn Met Thr Asp Ala Pro Thr
         420                 425                 430

 gcc ccc aaa gca gga act aca act gtg gca cca agt gca cca gac att     1462
 Ala Pro Lys Ala Gly Thr Thr Thr Val Ala Pro Ser Ala Pro Asp Ile
     435                 440                 445

 tct gct aat tct aga agt tta tct cag att ctg atg gaa caa ttg caa     1510
 Ser Ala Asn Ser Arg Ser Leu Ser Gln Ile Leu Met Glu Gln Leu Gln
 450                 455                 460                 465

 aag gag aaa cag ctg gtc act ggt atg gat ggt ggc cct gag gaa tgc     1558
 Lys Glu Lys Gln Leu Val Thr Gly Met Asp Gly Gly Pro Glu Glu Cys
                 470                 475                 480

 aaa aat aaa gat gat cag gga ttt gaa tca tgt gaa aag gta tca aat     1606
 Lys Asn Lys Asp Asp Gln Gly Phe Glu Ser Cys Glu Lys Val Ser Asn
             485                 490                 495

 tct gac aag cct ttg ata caa gat agt gac ttg aaa aca tct gat gcc     1654
 Ser Asp Lys Pro Leu Ile Gln Asp Ser Asp Leu Lys Thr Ser Asp Ala
         500                 505                 510

 tta cag tta gaa aat tct cag gaa att gaa act tct aat aaa aat gat     1702
 Leu Gln Leu Glu Asn Ser Gln Glu Ile Glu Thr Ser Asn Lys Asn Asp
     515                 520                 525

 atg act ata gat ata tta cat gct gat ggt gaa aga cct aat gtt cta     1750
 Met Thr Ile Asp Ile Leu His Ala Asp Gly Glu Arg Pro Asn Val Leu
 530                 535                 540                 545

 gaa aac cta gac aac tca aag gaa aag act gtt gga tca gaa gca gca     1798
 Glu Asn Leu Asp Asn Ser Lys Glu Lys Thr Val Gly Ser Glu Ala Ala
                 550                 555                 560

 aaa act gaa gat aca gtt ctc tgc agc agt gat aca gat gag gag tgt     1846
 Lys Thr Glu Asp Thr Val Leu Cys Ser Ser Asp Thr Asp Glu Glu Cys
             565                 570                 575

 tta atc att gat aca gaa tgt aaa aat aat agt gat gga aag aca gct     1894
 Leu Ile Ile Asp Thr Glu Cys Lys Asn Asn Ser Asp Gly Lys Thr Ala
         580                 585                 590

 gtt gtg ggt tct aac tta agt tcc aga cca gct agt cca aat tct tcc     1942
 Val Val Gly Ser Asn Leu Ser Ser Arg Pro Ala Ser Pro Asn Ser Ser
     595                 600                 605

 tca gga cag gct tct gta gga aac cag act aat act gct tgt agt cct     1990
 Ser Gly Gln Ala Ser Val Gly Asn Gln Thr Asn Thr Ala Cys Ser Pro
 610                 615                 620                 625

 gaa gag tca tgt gtt tta aaa aaa cct atc aaa cga gta tat aaa aaa     2038
 Glu Glu Ser Cys Val Leu Lys Lys Pro Ile Lys Arg Val Tyr Lys Lys
                 630                 635                 640

 ttt gat cca gtt gga gag att tta aaa atg cag gat gag ctc tta aag     2086
 Phe Asp Pro Val Gly Glu Ile Leu Lys Met Gln Asp Glu Leu Leu Lys
             645                 650                 655

 cca att tcc aga aaa gta cca gaa ttg ccc tta atg aat tta gaa aat     2134
 Pro Ile Ser Arg Lys Val Pro Glu Leu Pro Leu Met Asn Leu Glu Asn
         660                 665                 670

 tct aaa cag cct tct gtt tct gag caa ttg tct ggt cct tca gac tcc     2182
 Ser Lys Gln Pro Ser Val Ser Glu Gln Leu Ser Gly Pro Ser Asp Ser
     675                 680                 685

 tct agt tgg ccg aaa tct gga tgg cct tct gca ttt cag aag cca aaa     2230
 Ser Ser Trp Pro Lys Ser Gly Trp Pro Ser Ala Phe Gln Lys Pro Lys
 690                 695                 700                 705

 gga cga ttg cca tat gaa ctt cag gac tat gtt gaa gat aca tcg gaa     2278
 Gly Arg Leu Pro Tyr Glu Leu Gln Asp Tyr Val Glu Asp Thr Ser Glu
                 710                 715                 720

 tac cta gct cct cag gaa gga aat ttt gtt tat aag tta ttt agc ctg     2326
 Tyr Leu Ala Pro Gln Glu Gly Asn Phe Val Tyr Lys Leu Phe Ser Leu
             725                 730                 735

 caa gac ctg ttg tta ctc gta cgc tgc agt gtc cag agg ata gag aca     2374
 Gln Asp Leu Leu Leu Leu Val Arg Cys Ser Val Gln Arg Ile Glu Thr
         740                 745                 750

 aga cca cgt tct aaa aaa cgg aag aaa atc aga aga caa ttt cca gtt     2422
 Arg Pro Arg Ser Lys Lys Arg Lys Lys Ile Arg Arg Gln Phe Pro Val
     755                 760                 765

 tat gta cta cca aaa gta gag tat caa gct tgt tac gga gtt gaa gct     2470
 Tyr Val Leu Pro Lys Val Glu Tyr Gln Ala Cys Tyr Gly Val Glu Ala
 770                 775                 780                 785

 ctg act gaa agt gaa ctt tgt cgc tta tgg act gaa agt tta ttg cat     2518
 Leu Thr Glu Ser Glu Leu Cys Arg Leu Trp Thr Glu Ser Leu Leu His
                 790                 795                 800

 tcc aac agc tca ttt tat gtt ggg cat atc gat gca ttt act tca aaa     2566
 Ser Asn Ser Ser Phe Tyr Val Gly His Ile Asp Ala Phe Thr Ser Lys
             805                 810                 815

 ctt ttt cta ctg gaa gaa att acc tca gaa gaa tta aaa gaa aag ctt     2614
 Leu Phe Leu Leu Glu Glu Ile Thr Ser Glu Glu Leu Lys Glu Lys Leu
         820                 825                 830

 tca gca ctc aag att tcc aat tta ttt aac atc ctc caa cac att cta     2662
 Ser Ala Leu Lys Ile Ser Asn Leu Phe Asn Ile Leu Gln His Ile Leu
     835                 840                 845

 aag aaa cta agt agc ttg cag gag ggt tcc tac ttg tta tct cat gca     2710
 Lys Lys Leu Ser Ser Leu Gln Glu Gly Ser Tyr Leu Leu Ser His Ala
 850                 855                 860                 865

 gca gaa gat tct tca ctc ctg att tat aag gcc tct gat gga aaa gtt     2758
 Ala Glu Asp Ser Ser Leu Leu Ile Tyr Lys Ala Ser Asp Gly Lys Val
                 870                 875                 880

 act agg aca gca tac aat ttg tat aaa aca cat tgc ggc ctt cct ggt     2806
 Thr Arg Thr Ala Tyr Asn Leu Tyr Lys Thr His Cys Gly Leu Pro Gly
             885                 890                 895

 gta cct tcc agt ctc tca gtt ccc tgg gtc cca tta gat ccc agc ctg     2854
 Val Pro Ser Ser Leu Ser Val Pro Trp Val Pro Leu Asp Pro Ser Leu
         900                 905                 910

 tta tta cca tat cat atc cat cat gga aga ata cct tgt act ttt cca     2902
 Leu Leu Pro Tyr His Ile His His Gly Arg Ile Pro Cys Thr Phe Pro
     915                 920                 925

 ccg aaa tca ctg gat acc aca aca caa caa aag att ggt gga acg aga     2950
 Pro Lys Ser Leu Asp Thr Thr Thr Gln Gln Lys Ile Gly Gly Thr Arg
 930                 935                 940                 945

 atg cct aca cgc agc cac agg aat cca gtt tcc atg gaa acc aaa agc     2998
 Met Pro Thr Arg Ser His Arg Asn Pro Val Ser Met Glu Thr Lys Ser
                 950                 955                 960

 agt tgc ttg cct gct cag caa gtt gaa act gaa gga gtg gct cca cat     3046
 Ser Cys Leu Pro Ala Gln Gln Val Glu Thr Glu Gly Val Ala Pro His
             965                 970                 975

 aaa aga aaa ata act tga ggactg taccatggaa aactaaattt aaaaaaccag     3100
 Lys Arg Lys Ile Thr 
         980

 ttataacagt gtttaattta gataagtttg agggaaaata atcagtaggc aagaggaaca   3160

 tttttcctgt agtagctaga gtgccttgaa aaaatgtgtt ggctatgtga aggaatattt   3220

 caactaaaat ggaatggtat gcttttcacc cttgaagttt gaggaggatc ttgatatgtt   3280

 ttaacattat catggcaggg aaatatataa agaagaaaaa tatttttaca ttaaaccttt   3340

 tctaaaaatt gtaaatagaa aaataatttg gttttttatc aagaacaaca cttatcgtta   3400

 tgtattgtgt tagttatatt gccagtctgt tgcgactgac tcaaaaagtt aaatgttgcc   3460

 actgctgaag atgattatga gcatcgcaaa ctttgtttct gacccatttt gacagttttt   3520

 atatactcct ttaaaatgat gaatgttaca ggttaataaa gttaatacct ttaaaaactt   3580

 ggtgaaattc cattacagaa gccaaaaata aaaactccct gcctctgaaa agtcagatta   3640

 a                                                                   3641




      <210> 182
      <211> 1326
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(517)

      <400> 182
 cggctcgaca ggcggcgcgg gcggcggtaa a   atg tcg gtt cca gga cct tac      52
                                      Met Ser Val Pro Gly Pro Tyr
                                        1               5

 cag gcg gcc act ggg cct tcc tca gca cca tcc gca cct cca tcc tat      100
 Gln Ala Ala Thr Gly Pro Ser Ser Ala Pro Ser Ala Pro Pro Ser Tyr
          10                  15                  20

 gaa gag aca gtg gct gtt aac agt tat tac ccc aca cct cca gct ccc      148
 Glu Glu Thr Val Ala Val Asn Ser Tyr Tyr Pro Thr Pro Pro Ala Pro
      25                  30                  35

 atg cct ggg cca act acg ggg ctt gtg acg ggg cct gat ggg aag ggc      196
 Met Pro Gly Pro Thr Thr Gly Leu Val Thr Gly Pro Asp Gly Lys Gly
  40                  45                  50                  55

 atg aat cct cct tcg tat tat acc cag cca gcg ccc atc ccc aat aac      244
 Met Asn Pro Pro Ser Tyr Tyr Thr Gln Pro Ala Pro Ile Pro Asn Asn
                  60                  65                  70

 aat cca att acc gtg cag acg gtc tac gtg cag cac ccc atc acc ttt      292
 Asn Pro Ile Thr Val Gln Thr Val Tyr Val Gln His Pro Ile Thr Phe
              75                  80                  85

 ttg gac cgc cct gtc caa atg tgt tgt cct tcc tgc aac aag atg atc      340
 Leu Asp Arg Pro Val Gln Met Cys Cys Pro Ser Cys Asn Lys Met Ile
          90                  95                 100

 gtg agt cag ctg tcc tat aac gcc ggt gct ctg acc tgg ctg tcc tgc      388
 Val Ser Gln Leu Ser Tyr Asn Ala Gly Ala Leu Thr Trp Leu Ser Cys
     105                 110                 115

 ggg agc ctg tgc ctg ctg ggg tgc ata gcg ggc tgc tgc ttc atc ccc      436
 Gly Ser Leu Cys Leu Leu Gly Cys Ile Ala Gly Cys Cys Phe Ile Pro
 120                 125                 130                 135

 ttc tgc gtg gat gcc ctg cag gac gtg gac cat tac tgt ccc aac tgc      484
 Phe Cys Val Asp Ala Leu Gln Asp Val Asp His Tyr Cys Pro Asn Cys
                 140                 145                 150

 aga gct ctc ctg ggc acc tac aag cgt ttg tag gactcagc cagacgtgga      535
 Arg Ala Leu Leu Gly Thr Tyr Lys Arg Leu 
             155                 160

 gggagccggg tgccgcagga agtcctttcc acctctcatc cagcttcacg cctggtggag    595

 gttctgccct ggtggtctca cctctccagg gggcccacct tcatgtcttc ttttgggggg    655

 aatacgtcgc aaaactaaca aatctccaaa ccccagaaat tgctgcttgg agtcgtgcat    715

 aggacttgca aagacattcc ccttgagtgt cagttccacg gtttcctgcc tccctgagac    775

 cctgagtcct gccatctaac tgtgatcatt gccctatccg aatatcttcc tgtgatctgc    835

 catcagtggc tcttttttcc tgcttccatg ggcctttctg gtggcagtct caaactgaga    895

 agccacagtt gccttatttt tgaggctgtt ctgcccagag ctcggctgaa ccagccttta    955

 gtgcctacca ttatcttatc cgtctcttcc cgtccctgat gacaaagatc ttgccttaca   1015

 gactttacag gcttggcttt gagattctgt aactgcagac ttcattagca cacagattca   1075

 ctttaatttc ttaatttttt tttttaaata caaggagggg gctattaaca cccagtacag   1135

 acatatccac aaggtcgtaa atgcatgcta gaaaaatagg gctggatctt atcactgccc   1195

 tgtctcccct tgtttctctg tgccagatct tcagtgcccc tttccataca gggatttttt   1255

 tctcatagag taattatatg aacagttttt atgacctcct tttggtctga aatacttttg   1315

 aacagaattt c                                                        1326




      <210> 183
      <211> 548
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (42)..(419)

      <400> 183
 tacaaggctg cggcgtctgc tgctattctc cgagctacgc a    atg ccg cct aag      53
                                                  Met Pro Pro Lys
                                                    1

 gac gac acg atc aag aac gac gct gaa cag tca gtc atc aaa gac cta      101
 Asp Asp Thr Ile Lys Asn Asp Ala Glu Gln Ser Val Ile Lys Asp Leu
   5                  10                  15                  20

 gac cca gtg aac aaa tcc ggg ggc atc gcc caa aag aag atc cgt gcc      149
 Asp Pro Val Asn Lys Ser Gly Gly Ile Ala Gln Lys Lys Ile Arg Ala
                  25                  30                  35

 ata ggc aga gct cgg gac atg ctc aac tac tca gac ttg ctt gac gaa      197
 Ile Gly Arg Ala Arg Asp Met Leu Asn Tyr Ser Asp Leu Leu Asp Glu
              40                  45                  50

 gct acc tat gat aaa ctc tgt aag gaa gtt ccc aac tat aaa ctt ata      245
 Ala Thr Tyr Asp Lys Leu Cys Lys Glu Val Pro Asn Tyr Lys Leu Ile
          55                  60                  65

 acc cca gcc gtg ggc tct gat aga ctg aat att gaa ggc tcc ctg gcc      293
 Thr Pro Ala Val Gly Ser Asp Arg Leu Asn Ile Glu Gly Ser Leu Ala
      70                  75                  80

 agg gca gcc ctt cag gag ctc ctt cgt cac ggc ctt atc aca ctg gtt      341
 Arg Ala Ala Leu Gln Glu Leu Leu Arg His Gly Leu Ile Thr Leu Val
  85                  90                  95                 100

 tca aag cac aga gct cca gtc att tac ccc cga aat cac aag ggt ggc      389
 Ser Lys His Arg Ala Pro Val Ile Tyr Pro Arg Asn His Lys Gly Gly
                 105                 110                 115

 act gct cca aca gca ggt gcc gat gca tga a acacaaccgc ccgatgtaca      440
 Thr Ala Pro Thr Ala Gly Ala Asp Ala 
             120                 125

 aaagacaaca tccacattta taaaataaaa cacccgcagc aaaaaacaga aggggggcac    500

 gtacaaaata caacctataa tgcgtaaaat acaattctct accgacag                 548




      <210> 184
      <211> 696
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(483)

      <400> 184
 cccacgcgtc cgctccgggc tacaggcgac agagctgagc caagcgttta ctgggcagct     60

 gttacgctca gattccaa  atg aaa atg ttt gag agc gct gac tct aca gcc     111
                      Met Lys Met Phe Glu Ser Ala Asp Ser Thr Ala
                        1               5                  10

 aca aga tct ggc cag gat ctc tgg gct gaa att tgt tcc tgt ctg cca      159
 Thr Arg Ser Gly Gln Asp Leu Trp Ala Glu Ile Cys Ser Cys Leu Pro
              15                  20                  25

 aat cct gaa caa gaa gat ggt gcc aac aat gca ttc tca gac tcc ttt      207
 Asn Pro Glu Gln Glu Asp Gly Ala Asn Asn Ala Phe Ser Asp Ser Phe
          30                  35                  40

 gtg gat tct tgc cct gaa ggt gaa ggc cag agg gag gtg gct gac ttt      255
 Val Asp Ser Cys Pro Glu Gly Glu Gly Gln Arg Glu Val Ala Asp Phe
      45                  50                  55

 gct gtc cag cca gct gta aag cct tgg gct ccc ttg cag gat tca gaa      303
 Ala Val Gln Pro Ala Val Lys Pro Trp Ala Pro Leu Gln Asp Ser Glu
  60                  65                  70                  75

 gtg tat tta gca tct cta gag aag aag cta aga aga atc aaa ggt tta      351
 Val Tyr Leu Ala Ser Leu Glu Lys Lys Leu Arg Arg Ile Lys Gly Leu
                  80                  85                  90

 aat cag gaa gtg act tcc aag gac atg ctt cga act ctg gcc caa gcc      399
 Asn Gln Glu Val Thr Ser Lys Asp Met Leu Arg Thr Leu Ala Gln Ala
              95                 100                 105

 aag aag gaa tgc tgg gat cgg ttc ctc cag gag aag tta gct tca gag      447
 Lys Lys Glu Cys Trp Asp Arg Phe Leu Gln Glu Lys Leu Ala Ser Glu
         110                 115                 120

 ttc ttt gtg gat gga ctt gat tct gat gag agg taa tcga ttccccgtct      497
 Phe Phe Val Asp Gly Leu Asp Ser Asp Glu Arg 
     125                 130

 agttccagct gaaatcatcc tttatgtagt tgttctattt gtttttagcc cagcagtaga    557

 tttttaagaa cagacttttt tgccaaaagg caaatactgc agctacgtgt tggtcacaga    617

 ttgaatagag ttaaggataa agcattgtgt tcatttttaa gtatgcaatg aacttgagaa    677

 agtagtaaaa aaaaaaaaa                                                 696




      <210> 185
      <211> 2776
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (203)..(2293)

      <400> 185
 tttcgtacgc gcttcctctt gtaacccggt caggcctagg gttcctccct gagttccaga     60

 ataggccacc cagttggggc ggacccttaa ggcattctgg gcccacgcct gcctataaac    120

 cctcatagtg tgacctttga cccctggtgt gatcttgggc ccgggctggg accagcccct    180

 agtgtgggtt gtgggggcgg cc atg gag ctg ggc agc tgc ttc aag acc tat     232
                          Met Glu Leu Gly Ser Cys Phe Lys Thr Tyr
                            1               5                  10

 gag gac ttc aag gag tgc ttc agc gcc tac aaa agg gag aac agg tgc      280
 Glu Asp Phe Lys Glu Cys Phe Ser Ala Tyr Lys Arg Glu Asn Arg Cys
                  15                  20                  25

 tcc ttc att ctc agg gac tgc gtc tcc gtc cgc ttc cac aac ctc aac      328
 Ser Phe Ile Leu Arg Asp Cys Val Ser Val Arg Phe His Asn Leu Asn
              30                  35                  40

 cat ggc acc tcc atc cgc gaa gac atc ctg tat gtg cag gtg aaa ttt      376
 His Gly Thr Ser Ile Arg Glu Asp Ile Leu Tyr Val Gln Val Lys Phe
          45                  50                  55

 gtc tgc att cgg acc caa tca aac agg aag aga acg cgg gag gca gac      424
 Val Cys Ile Arg Thr Gln Ser Asn Arg Lys Arg Thr Arg Glu Ala Asp
      60                  65                  70

 atg tgc cca gcg tac ttg ctc cta agg tac aac gag aga cta gat aga      472
 Met Cys Pro Ala Tyr Leu Leu Leu Arg Tyr Asn Glu Arg Leu Asp Arg
  75                  80                  85                  90

 cta ttt atc agt gaa cta aac aca cag cac ata cat ggt gac tct aaa      520
 Leu Phe Ile Ser Glu Leu Asn Thr Gln His Ile His Gly Asp Ser Lys
                  95                 100                 105

 gtg gct agt cct gga gga gac acc act ggc aaa tct caa aag aca atg      568
 Val Ala Ser Pro Gly Gly Asp Thr Thr Gly Lys Ser Gln Lys Thr Met
             110                 115                 120

 tgc ctg cag aga ctc cag cct gtg cag ccc aca acc aaa aaa gac ctt      616
 Cys Leu Gln Arg Leu Gln Pro Val Gln Pro Thr Thr Lys Lys Asp Leu
         125                 130                 135

 gac act gcc gag aag tcc ctg gtt gag cca tcg ttt tgc cta gat aag      664
 Asp Thr Ala Glu Lys Ser Leu Val Glu Pro Ser Phe Cys Leu Asp Lys
     140                 145                 150

 gta caa gtg tcc tca aag cca gag cag gaa ggc atc act cct tct gac      712
 Val Gln Val Ser Ser Lys Pro Glu Gln Glu Gly Ile Thr Pro Ser Asp
 155                 160                 165                 170

 ctg gcc aag ata gca aaa gtg atg aag aac ttt ctt aag gta gat gag      760
 Leu Ala Lys Ile Ala Lys Val Met Lys Asn Phe Leu Lys Val Asp Glu
                 175                 180                 185

 ggt tcc atg gct tcc ttc agt gtg ggt gac agc cag cac ctg gac cgg      808
 Gly Ser Met Ala Ser Phe Ser Val Gly Asp Ser Gln His Leu Asp Arg
             190                 195                 200

 ctc agc ttc cag agc agt aag atg acc gac ctg ttc atc cgc ttc cca      856
 Leu Ser Phe Gln Ser Ser Lys Met Thr Asp Leu Phe Ile Arg Phe Pro
         205                 210                 215

 gag aat ctc ttg cta cac cgg gtg gag aac acc cag ggc cac atc ctc      904
 Glu Asn Leu Leu Leu His Arg Val Glu Asn Thr Gln Gly His Ile Leu
     220                 225                 230

 tat gct ttc ttg gtg gag aac aag gaa cga gaa agt cga gtg gtg cac      952
 Tyr Ala Phe Leu Val Glu Asn Lys Glu Arg Glu Ser Arg Val Val His
 235                 240                 245                 250

 ttt gct gtg ctc aag gcg gag aca gtc acc tct gtg gcc aag atg ctg     1000
 Phe Ala Val Leu Lys Ala Glu Thr Val Thr Ser Val Ala Lys Met Leu
                 255                 260                 265

 agc atc ttc aca gag ttc aac tcc gat tgg ccc aag gtc aag gtg gtc     1048
 Ser Ile Phe Thr Glu Phe Asn Ser Asp Trp Pro Lys Val Lys Val Val
             270                 275                 280

 ttt gtg gac cct tca ttc cat tac cgg gct atc ctg cag gag atc ttt     1096
 Phe Val Asp Pro Ser Phe His Tyr Arg Ala Ile Leu Gln Glu Ile Phe
         285                 290                 295

 cct gct gcc cgc atc ctc ctt tcc atc tac cac aca acc cga ctc ttg     1144
 Pro Ala Ala Arg Ile Leu Leu Ser Ile Tyr His Thr Thr Arg Leu Leu
     300                 305                 310

 gag aag aag ttg cat cgt agt tca gca aat cca tcc ttt aaa agg ctc     1192
 Glu Lys Lys Leu His Arg Ser Ser Ala Asn Pro Ser Phe Lys Arg Leu
 315                 320                 325                 330

 atg aag gaa gcc ctg cgg gag gcc gtg ttt gtc act tct gaa gcc agc     1240
 Met Lys Glu Ala Leu Arg Glu Ala Val Phe Val Thr Ser Glu Ala Ser
                 335                 340                 345

 ctg aaa aat ctc tgc cag atg tcc cag gcc gta ctg gat gag gat ctc     1288
 Leu Lys Asn Leu Cys Gln Met Ser Gln Ala Val Leu Asp Glu Asp Leu
             350                 355                 360

 ttc aac ttc ctg cag gcc cac tgg ttc acc tgt gaa ctg ctg tgg tac     1336
 Phe Asn Phe Leu Gln Ala His Trp Phe Thr Cys Glu Leu Leu Trp Tyr
         365                 370                 375

 atg cat gtt agg aag ggc ctg ctt gcg tgt aac acc tac atg gac agc     1384
 Met His Val Arg Lys Gly Leu Leu Ala Cys Asn Thr Tyr Met Asp Ser
     380                 385                 390

 cta gac att gtc acc agc aag gtg tca agc ctc ttt cgg gaa cag cag     1432
 Leu Asp Ile Val Thr Ser Lys Val Ser Ser Leu Phe Arg Glu Gln Gln
 395                 400                 405                 410

 tcg ctg ctg gac tgc atc ctc tgc ttt gtg gat tac ata gac ttc ttt     1480
 Ser Leu Leu Asp Cys Ile Leu Cys Phe Val Asp Tyr Ile Asp Phe Phe
                 415                 420                 425

 aat acc aaa ggc ttg aag aac ttg ccc aca cct cct ccc aaa tta aag     1528
 Asn Thr Lys Gly Leu Lys Asn Leu Pro Thr Pro Pro Pro Lys Leu Lys
             430                 435                 440

 aga gct cgg ccg gca agc atg cca ctg aag tcc aag aag gct ttt gga     1576
 Arg Ala Arg Pro Ala Ser Met Pro Leu Lys Ser Lys Lys Ala Phe Gly
         445                 450                 455

 atc tgt gga gag agc ctt acc agc ctc cct gca gaa gag acc aag cca     1624
 Ile Cys Gly Glu Ser Leu Thr Ser Leu Pro Ala Glu Glu Thr Lys Pro
     460                 465                 470

 gac gca cag cag gta cag gta cag cag cag tca caa gtg ccg ccc tcg     1672
 Asp Ala Gln Gln Val Gln Val Gln Gln Gln Ser Gln Val Pro Pro Ser
 475                 480                 485                 490

 cag gtt ggc atg ctg gac acc ttg cac cag agt ggc tct gaa cta gcc     1720
 Gln Val Gly Met Leu Asp Thr Leu His Gln Ser Gly Ser Glu Leu Ala
                 495                 500                 505

 tac aag ctg tgc cac aat gag tgg gag gtg gta cag aac tcc acc cac     1768
 Tyr Lys Leu Cys His Asn Glu Trp Glu Val Val Gln Asn Ser Thr His
             510                 515                 520

 ctg gtg gac atg gct ggc tct tca gtg gac gtt cag ctg cta gag gac     1816
 Leu Val Asp Met Ala Gly Ser Ser Val Asp Val Gln Leu Leu Glu Asp
         525                 530                 535

 tct cac cag gtt agc aaa gat ggc tgt agc tgc agc tgt tcc ttt caa     1864
 Ser His Gln Val Ser Lys Asp Gly Cys Ser Cys Ser Cys Ser Phe Gln
     540                 545                 550

 caa tgg tac cac ctg cca tgc cga cac att ttg gct ctg ctg cac acc     1912
 Gln Trp Tyr His Leu Pro Cys Arg His Ile Leu Ala Leu Leu His Thr
 555                 560                 565                 570

 agc cag cag ccg gtt ggt gaa gcc atg gtg tgc cgc cgg tgg cag aag     1960
 Ser Gln Gln Pro Val Gly Glu Ala Met Val Cys Arg Arg Trp Gln Lys
                 575                 580                 585

 aag tac cag tac ctc ctt ggg ccc aat ggg gag ctc cag gat cgt ggt     2008
 Lys Tyr Gln Tyr Leu Leu Gly Pro Asn Gly Glu Leu Gln Asp Arg Gly
             590                 595                 600

 atg gtc cca aac aca ggc cag cct gag aag caa gga cgg aac gac atg     2056
 Met Val Pro Asn Thr Gly Gln Pro Glu Lys Gln Gly Arg Asn Asp Met
         605                 610                 615

 att cag gac cta agc agg gag tta gca aac ctg ctc atg cag acc gag     2104
 Ile Gln Asp Leu Ser Arg Glu Leu Ala Asn Leu Leu Met Gln Thr Glu
     620                 625                 630

 ggg cca gag ctg gag gaa cgc tac tcc acc ctg cgc aag att gtg gat     2152
 Gly Pro Glu Leu Glu Glu Arg Tyr Ser Thr Leu Arg Lys Ile Val Asp
 635                 640                 645                 650

 atc tgg gct ggc ccc tcc cag cca tct gag ctc ttt cag cag cca gga     2200
 Ile Trp Ala Gly Pro Ser Gln Pro Ser Glu Leu Phe Gln Gln Pro Gly
                 655                 660                 665

 gac ttt aag gac gtg ggc cgc ctc cct ttc ctc tgg gga aag caa gaa     2248
 Asp Phe Lys Asp Val Gly Arg Leu Pro Phe Leu Trp Gly Lys Gln Glu
             670                 675                 680

 gaa ggg gag gga ttc cct cct gct aca gct gtg atg cat tat tga agc     2296
 Glu Gly Glu Gly Phe Pro Pro Ala Thr Ala Val Met His Tyr 
         685                 690                 695

 actttagctg aagcattgga ccacaaacac ttctccttgg aagtgtgaga gtttaaagtg   2356

 ggcaggacat actagggttt agcattttag ccaatgtctt cctaggtggg gctaggaata   2416

 ttgttacagt agagaggaag ggaactccac tgtgtgacag tcctttcaat ctgccccttt   2476

 tcagccctac ttttggcatt ccttgggagc ctcagttgtt gttcaaggcc aaagttatct   2536

 ccgtgctgca aggtcaccct cttcctcccc cagcccctga gatcagatct tatttgctct   2596

 gcaaagatga atccctgcct caggttaggg tgagacaaaa tcggtctggt aaaagggcct   2656

 gttttcaggg acaaagggaa tgaggatgat ctttggctgt tgctgctctt tatgaagaat   2716

 cttatttgta actttttatt catattaaag ttgtttttaa taaaattaaa aaaaaaaaaa   2776




      <210> 186
      <211> 2549
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2252)..(2452)

      <400> 186
 cttttttcaa actaaattag aaaggggtgt cattatttga ctgttaaacc aaaatatttt     60

 tggtgggtct ttttatggaa gtttaaagaa aggacatcat catagatatg atctaacagt    120

 atttttaact atatttgatc attaaaagcc tcttggaatt tgaagcgtga cgtgtttcta    180

 atgccccttg agaggtgaaa aataccacat aatgatcagt atgctgtgcc agcttcattt    240

 ggggagaaat aactagtaga aagttctggg tgtgaggtgt acagcagtct aggtggcata    300

 gtgatggaaa gggatcagag tctgactgtc actcagaatc ctgggctcag ttgcttgaca    360

 accttgggaa aattgtttta tctttgtgcg tctgtttgct gatcttcagc gtgggaataa    420

 taacagtacc tacttgaaag gatcattgtg cggattaaaa gaaataatat atgtaaagca    480

 ctttaacaca gcaccaggcc cacggaaagt ggctaatgtt agctactatg aatggtgcca    540

 gtgaagacac tgaaaaataa gtgatttcag taaccttctg gaaagctatc agtttcaaat    600

 aatattttct ctgtaatatg agatgaaatt aaaagtggat agctttcagg aaagataaag    660

 agaacatgct tagaatgtaa gctaaacaga ttttttctgt tgctctttga aaactatgag    720

 ccctggccag cttaacctgg tctgaggtga gactaaacac aaaaacagta gataaatctc    780

 tccctaaaag atggattccc ccacataccc atgctactag tttctctgtc tattcacaca    840

 tatgtacaaa tacatgaaca cagcctgtct gtgctcagac atagagaagt actacctgac    900

 ttgagtcaat gcacccaaga agaaaagctt ggagtagagc agaagggagg gcttgggact    960

 cctgtctttc cagcatgccc tggggtgcag tggtcagcca cctgaagaga gagccaatag   1020

 catggggttt acaaggcaaa gatagccatt cattcaacac atattcatag agctccttct   1080

 ctgtgccaga cactgttctg gaagatagct agatgaaaat ctttgcactc acagagctta   1140

 catgccagtg agtgaagatc gatgataaat aaagcaaatg catcatatgt tcacatttga   1200

 taagtatatg ccaaaaaatg aagccgggaa ggaggacaag gcccatgggt gggtgttgag   1260

 gtttttaaag tgtggtcagg aaaggcccca ctgataaggt aacatttgag caagtctgaa   1320

 aaaggcaagg ggatctttgg ggctaacttc gggatccctg cactttatgt aagaatgtaa   1380

 acctggagtc tcatttaaga atgatcagca atacgtttag aacatatgaa ctgaatgaaa   1440

 tggacatttt ttcttaattt acgtataaat ccatatgatt atacataaag ttctgatgca   1500

 ttaataaaag cagccaaata gggccaaaga gaaaaataac aggactctgt actggaccta   1560

 actttatcat taattaggta atattttcct catttcttta ctgctgccat tttcctcacc   1620

 agtattccag agatggtcat agctcattac tctaccacca agaacctaaa aggaattaga   1680

 atacagcaga attggcctca gtgaagagct taaaattgtt ctcctcgtag aactggacta   1740

 ttgatcatta ccacgtgacg ttggctctat tactttctgt tcccaatgtc cttctagtgg   1800

 tttgaaaatg ttaaaacatc cctaaaatct aaatcatata atcagaattc tatagtgtcc   1860

 cactctatct gtaaagatca tttggaagac tttagactct attaatttta aaaggaatat   1920

 ttattagcca tatgcagaat ttctaatgat gatattgtac agcttctaat tcacttttca   1980

 gatcagtgtt tgaaatggca attatcagtg ttggatttag ttccaactac ttgatttaca   2040

 aaaatgtaca tttagagaag gttaaaagaa acagtgagaa atgtaaacat tcaaaatgat   2100

 aattgaatct ctcagttgtg ggaataatta tcagagacat gcaactgaaa atgtctcacc   2160

 tttcatcttt ttttcttaat tcataaagtt atcttgtaga atttgatgag accctcctag   2220

 tcattctcaa ctggggcggt gctgtcaccg a   atg gtg ttt gag agt gtt ggg    2272
                                      Met Val Phe Glu Ser Val Gly
                                        1               5

 gct agg gca cat ttt tgg ttg tca cag caa ctg ggg tgg cat ttg ctg     2320
 Ala Arg Ala His Phe Trp Leu Ser Gln Gln Leu Gly Trp His Leu Leu
          10                  15                  20

 ccc agt gcc agg aat agt aac att atg aat gcc agg gac agt gtg ctc     2368
 Pro Ser Ala Arg Asn Ser Asn Ile Met Asn Ala Arg Asp Ser Val Leu
      25                  30                  35

 agt aaa gtc ttc cat ccc aaa agg ggc aag gaa ggg gga tca gct gta     2416
 Ser Lys Val Phe His Pro Lys Arg Gly Lys Glu Gly Gly Ser Ala Val
  40                  45                  50                  55

 atc cag cac ttg gga gcc cac ggg gcg gtc acc tga gcca gggtcgagcc     2466
 Ile Gln His Leu Gly Ala His Gly Ala Val Thr 
                  60                  65

 acctcgccaa ggtgaacctg tgcctaacat tcaacacgct cggcggcggc cagccaacac   2526

 caccaagcag agggcggacc cga                                           2549




      <210> 187
      <211> 884
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (381)..(668)

      <220>
      <221> misc_feature
      <222> (1)...(884)
      <223> n = a,t,c or g

      <400> 187
 cagtgtcgtg gaattccaag aacgacttcc aaatgcaggg atggaatata agcagaacgt     60

 catgggctca gcagtgactc caccacccga ggccgaggcc gtgcttctgg aagatagaag    120

 gagacatcat cgtgtgtttc ccctcccctt gcccctgtta agaaacgtat caatacccat    180

 tggatgatca aggctaccgt atttcttcta ttttttttta tagtgcctgc caggcacttt    240

 gttttatgtt tccaatagca cttcctgaaa taaaccaaag caacactgct caaggcccct    300

 ggggcgatgg agaaggccac ccacctcact gacagtccca agaatgaccg gctgcgaggt    360

 cctagtcaaa agtcaacatt    atg acc tgg gga ctc cag cat cct tca agc     410
                          Met Thr Trp Gly Leu Gln His Pro Ser Ser
                            1               5                  10

 aag cca ttt ccg aag aag gtg aaa aga agc cag gat gat tgg cac ctc      458
 Lys Pro Phe Pro Lys Lys Val Lys Arg Ser Gln Asp Asp Trp His Leu
                  15                  20                  25

 ctc ctc ctc ctc ctc ttc ttc ctc ttc cct tgc cca gcc ccc tcc tgt      506
 Leu Leu Leu Leu Leu Phe Phe Leu Phe Pro Cys Pro Ala Pro Ser Cys
              30                  35                  40

 gcg tgt gtt tca gac aac aca gga gcc agc aca gga gtg gaa aat cct      554
 Ala Cys Val Ser Asp Asn Thr Gly Ala Ser Thr Gly Val Glu Asn Pro
          45                  50                  55

 gca gcg caa ctc agc tca gcc cac aga agc ctt ggg aat ggc ctc agt      602
 Ala Ala Gln Leu Ser Ser Ala His Arg Ser Leu Gly Asn Gly Leu Ser
      60                  65                  70

 ttg tgc aat aag aag att ttt ttt ttt ttt tta aat ctt cat tat att      650
 Leu Cys Asn Lys Lys Ile Phe Phe Phe Phe Leu Asn Leu His Tyr Ile
  75                  80                  85                  90

 ttc ttt gat tgt ctg tga gaaagt acccaggtcc gcctggaatt actctacagt      704
 Phe Phe Asp Cys Leu 
                  95

 agaaataact ggaacacaaa caaactgatt ggganaaaaa gagttaactg atttttattt    764

 attttcaata ttttaaaaag ggataaaagt gctggacagg ggcacagttt tttttgtttt    824

 taaaggtacc ttactacctt taaaagttta ggcgccattt tttgtggagg actgggattt    884




      <210> 188
      <211> 821
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(768)

      <400> 188
 gagcttgagt ccggacacca acgacgggga cgctgggaag ccgacttccg gcgccctatt     60

 ttctcacctg gttcccgcgg cgagccagcg gcagcggcgg cggcg    atg aga cag     114
                                                      Met Arg Gln
                                                        1

 aag cac tac ctt gag gct gca gcg cgg gga ctg cac gac agc tgc ccg      162
 Lys His Tyr Leu Glu Ala Ala Ala Arg Gly Leu His Asp Ser Cys Pro
       5                  10                  15

 ggc caa gcc cgc tac ctc ctc tgg gcc tac act tcg tcg cac gat gat      210
 Gly Gln Ala Arg Tyr Leu Leu Trp Ala Tyr Thr Ser Ser His Asp Asp
  20                  25                  30                  35

 aag agc act ttt gaa gaa acg tgt cca tac tgt ttc cag ctg ttg gtt      258
 Lys Ser Thr Phe Glu Glu Thr Cys Pro Tyr Cys Phe Gln Leu Leu Val
                  40                  45                  50

 ctg gat aac tct cga gtg cgt ctc aaa ccc aaa gcc agg ttg aca ccc      306
 Leu Asp Asn Ser Arg Val Arg Leu Lys Pro Lys Ala Arg Leu Thr Pro
              55                  60                  65

 aaa ata cag aaa ctt ctt aat cga gaa gcg aga aac tat aca ctc agt      354
 Lys Ile Gln Lys Leu Leu Asn Arg Glu Ala Arg Asn Tyr Thr Leu Ser
          70                  75                  80

 ttt aaa gaa gca aaa atg gtg aaa aag ttc aaa gac tcc aaa agt gta      402
 Phe Lys Glu Ala Lys Met Val Lys Lys Phe Lys Asp Ser Lys Ser Val
      85                  90                  95

 ttg ttg atc act tgt aaa aca tgc aac aga aca gtg aaa cat cat ggt      450
 Leu Leu Ile Thr Cys Lys Thr Cys Asn Arg Thr Val Lys His His Gly
 100                 105                 110                 115

 aaa agt aga agc ttt gtg tca aca ttg aag agc aat cct gcc act cct      498
 Lys Ser Arg Ser Phe Val Ser Thr Leu Lys Ser Asn Pro Ala Thr Pro
                 120                 125                 130

 aca agt aaa ctc agc ctg aag aca cca gag aga agg act gca aac cca      546
 Thr Ser Lys Leu Ser Leu Lys Thr Pro Glu Arg Arg Thr Ala Asn Pro
             135                 140                 145

 aat cat gac atg tct ggc tcg aaa ggc aag agc cca gca tcg gtt ttc      594
 Asn His Asp Met Ser Gly Ser Lys Gly Lys Ser Pro Ala Ser Val Phe
         150                 155                 160

 aga aca cct aca tct gga cag tca gta tct act tgc tcc tca aag aac      642
 Arg Thr Pro Thr Ser Gly Gln Ser Val Ser Thr Cys Ser Ser Lys Asn
     165                 170                 175

 acc agc aaa aca aag aaa cac ttc tct caa cta aaa atg tta ctt agt      690
 Thr Ser Lys Thr Lys Lys His Phe Ser Gln Leu Lys Met Leu Leu Ser
 180                 185                 190                 195

 cag aat gaa tcc caa aag att cca aag gtg gac ttc aga aat ttc tta      738
 Gln Asn Glu Ser Gln Lys Ile Pro Lys Val Asp Phe Arg Asn Phe Leu
                 200                 205                 210

 tct tct ctg aag ggt gga ctt tta aaa taa g aaatgcctga tgtcaattct      789
 Ser Ser Leu Lys Gly Gly Leu Leu Lys 
             215                 220

 gaaactaaag ttggtaaaac aaaaaaaaaa aa                                  821




      <210> 189
      <211> 585
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(538)

      <400> 189
 ggtg atg gcg ggg ccg gtg aag gac cgc gag gcc ttc cag agg ctc aac      49
      Met Ala Gly Pro Val Lys Asp Arg Glu Ala Phe Gln Arg Leu Asn
        1               5                  10                  15

 ttc ctg tac cag gtg agt ctg cga caa ggg ccc cac ggg gac ggt gct       97
 Phe Leu Tyr Gln Val Ser Leu Arg Gln Gly Pro His Gly Asp Gly Ala
                  20                  25                  30

 cgg cgt ccc aga gtg act gct ccc ctc ccg cag gcc gcc cat tgt gtc      145
 Arg Arg Pro Arg Val Thr Ala Pro Leu Pro Gln Ala Ala His Cys Val
              35                  40                  45

 ctt gcc cag gac ccc gag aac cag gcg ctg gcg agg ttt tac tgc tac      193
 Leu Ala Gln Asp Pro Glu Asn Gln Ala Leu Ala Arg Phe Tyr Cys Tyr
          50                  55                  60

 act gag agg acc att gcg aag cgg ctc gtc ttg cgg cgg gat ccc tcg      241
 Thr Glu Arg Thr Ile Ala Lys Arg Leu Val Leu Arg Arg Asp Pro Ser
      65                  70                  75

 gtg aag agg act ctc tgt cga ggc tgc tct tcc ctc ctc gtc ccg ggc      289
 Val Lys Arg Thr Leu Cys Arg Gly Cys Ser Ser Leu Leu Val Pro Gly
  80                  85                  90                  95

 ctc acc tgc acc cag cgc cag aga cgc tgc agg gga cag cgc tgg acc      337
 Leu Thr Cys Thr Gln Arg Gln Arg Arg Cys Arg Gly Gln Arg Trp Thr
                 100                 105                 110

 gta cag acc tgc cta aca tgc cag cgc agc caa cgc ttc ctc aat gat      385
 Val Gln Thr Cys Leu Thr Cys Gln Arg Ser Gln Arg Phe Leu Asn Asp
             115                 120                 125

 ccc ggg cat tta ctc tgg gga gac agg cct gag gcc cag ctc ggg agc      433
 Pro Gly His Leu Leu Trp Gly Asp Arg Pro Glu Ala Gln Leu Gly Ser
         130                 135                 140

 caa gca gat tcc aaa cca cta caa ccc ttg cca aac aca gcc cac tcc      481
 Gln Ala Asp Ser Lys Pro Leu Gln Pro Leu Pro Asn Thr Ala His Ser
     145                 150                 155

 att tca gac cgc ctt cct gag gag aaa atg cag acg aag ggt tcc agt      529
 Ile Ser Asp Arg Leu Pro Glu Glu Lys Met Gln Thr Lys Gly Ser Ser
 160                 165                 170                 175

 aac cag tga tggattc acctcatctc ccaaataaag tttacttgtt ttacattcca      585
 Asn Gln 






      <210> 190
      <211> 536
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (17)..(496)

      <400> 190
 ggaattcgca ggcaac    atg gcc gag agg ccg ggg cct ccg ggc ggc gcc      49
                      Met Ala Glu Arg Pro Gly Pro Pro Gly Gly Ala
                        1               5                  10

 gtg tcc gcg acc gcg tac cct gac acc ccc gcg gaa ttc cct ccg cac       97
 Val Ser Ala Thr Ala Tyr Pro Asp Thr Pro Ala Glu Phe Pro Pro His
              15                  20                  25

 ctc cag gcg ggt gcg atg cgg cgc cgc ttt tgg ggc gta ttc aac tgt      145
 Leu Gln Ala Gly Ala Met Arg Arg Arg Phe Trp Gly Val Phe Asn Cys
          30                  35                  40

 ctg tgc gcc ggc gcg ttc ggg gcc ctg gcc gcc gcc tcc gcc aag ctg      193
 Leu Cys Ala Gly Ala Phe Gly Ala Leu Ala Ala Ala Ser Ala Lys Leu
      45                  50                  55

 gcc ttc ggc agc gag gtg agc atg ggt tta tgc gtc tta ggc att att      241
 Ala Phe Gly Ser Glu Val Ser Met Gly Leu Cys Val Leu Gly Ile Ile
  60                  65                  70                  75

 gtg atg gcg agc acc aat tct ctg atg tgg acc ttc ttt agc cgg ggc      289
 Val Met Ala Ser Thr Asn Ser Leu Met Trp Thr Phe Phe Ser Arg Gly
                  80                  85                  90

 ctc agt ttc tcc atg tct tca gcc att gca tct gtc aca gtg act ttt      337
 Leu Ser Phe Ser Met Ser Ser Ala Ile Ala Ser Val Thr Val Thr Phe
              95                 100                 105

 tca aat atc ctc agc tcg gcc ttc ctg ggc tat gtg ctg tat gga gag      385
 Ser Asn Ile Leu Ser Ser Ala Phe Leu Gly Tyr Val Leu Tyr Gly Glu
         110                 115                 120

 tgc cag gag gtc ttg tgg tgg gga gga gtg ttc ctt att ctc tgc gga      433
 Cys Gln Glu Val Leu Trp Trp Gly Gly Val Phe Leu Ile Leu Cys Gly
     125                 130                 135

 ctc acc cta atc cac agg aag ctc cca ccc acc tgg aag ccc ctt cca      481
 Leu Thr Leu Ile His Arg Lys Leu Pro Pro Thr Trp Lys Pro Leu Pro
 140                 145                 150                 155

 cac aag cag cag tag caccacttgg ctagacggac cagctggaaa gatcatgatg      536
 His Lys Gln Gln 






      <210> 191
      <211> 1642
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (82)..(1209)

      <400> 191
 atgttcctaa agggtgaaaa atctgcggtt attaaagaaa ctcacctatc taagacatta     60

 gaagtcccaa catctagccc a  atg ctt ggt gca gag gct aca ttt atc ctc     111
                          Met Leu Gly Ala Glu Ala Thr Phe Ile Leu
                            1               5                  10

 ttc cag cct cca gca aat act ttc aca agc gct ttt tcc cag acc aga      159
 Phe Gln Pro Pro Ala Asn Thr Phe Thr Ser Ala Phe Ser Gln Thr Arg
                  15                  20                  25

 gca aga cgc gga ggc tcg ggg aga gga ggc ggc cag gag agc gca gag      207
 Ala Arg Arg Gly Gly Ser Gly Arg Gly Gly Gly Gln Glu Ser Ala Glu
              30                  35                  40

 gag acg agc gag ttc ggg gac cgt cac gcg cca gag gca gca gcg gcc      255
 Glu Thr Ser Glu Phe Gly Asp Arg His Ala Pro Glu Ala Ala Ala Ala
          45                  50                  55

 acg agg ggg agc gcg cgg gct ccg gag ccc aag cac gcc tca agc tgt      303
 Thr Arg Gly Ser Ala Arg Ala Pro Glu Pro Lys His Ala Ser Ser Cys
      60                  65                  70

 ggg act cgc ggg cag tgc gca tgc gct cga agg gag gtg gag gcg cag      351
 Gly Thr Arg Gly Gln Cys Ala Cys Ala Arg Arg Glu Val Glu Ala Gln
  75                  80                  85                  90

 gtc cgg gcg aag ggc gat acg gtg gcc gag agg gca cgg aga gga gga      399
 Val Arg Ala Lys Gly Asp Thr Val Ala Glu Arg Ala Arg Arg Gly Gly
                  95                 100                 105

 cgg tgg ctg acg aga tcc ggc atg gag cat ctg gag cgc tgc gag tgg      447
 Arg Trp Leu Thr Arg Ser Gly Met Glu His Leu Glu Arg Cys Glu Trp
             110                 115                 120

 ttg ttg cgg ggg acg ctg gtg cgg gcg gcc gtg cgg cgc tac ctg ccc      495
 Leu Leu Arg Gly Thr Leu Val Arg Ala Ala Val Arg Arg Tyr Leu Pro
         125                 130                 135

 tgg gcc ctg gtg gcc tcc atg ctg gcg ggc tcc ctc ctc aag gag ttg      543
 Trp Ala Leu Val Ala Ser Met Leu Ala Gly Ser Leu Leu Lys Glu Leu
     140                 145                 150

 tcc ccg ttg ccc gag agc tac ctc agc aac aag cgc aac gtc ctc aac      591
 Ser Pro Leu Pro Glu Ser Tyr Leu Ser Asn Lys Arg Asn Val Leu Asn
 155                 160                 165                 170

 gtg tat ttt gtc aaa gtg gcc tgg gcc tgg acg ttc tgt ctc ctt ctg      639
 Val Tyr Phe Val Lys Val Ala Trp Ala Trp Thr Phe Cys Leu Leu Leu
                 175                 180                 185

 cct ttc att gcc ctc acc aac tac cat ctg acc ggc aag gct ggc ttg      687
 Pro Phe Ile Ala Leu Thr Asn Tyr His Leu Thr Gly Lys Ala Gly Leu
             190                 195                 200

 gtc ctg cgg cgg ctg agc acc ctg ctt gtg ggc acg gcc atc tgg tac      735
 Val Leu Arg Arg Leu Ser Thr Leu Leu Val Gly Thr Ala Ile Trp Tyr
         205                 210                 215

 atc tgc acc tcc atc ttc tcc aac atc gaa cac tac acg ggc agc tgc      783
 Ile Cys Thr Ser Ile Phe Ser Asn Ile Glu His Tyr Thr Gly Ser Cys
     220                 225                 230

 tac cag tcc cca gcc ctg gag ggg gtc aga aag gaa cac cag agc aag      831
 Tyr Gln Ser Pro Ala Leu Glu Gly Val Arg Lys Glu His Gln Ser Lys
 235                 240                 245                 250

 cag cag tgc cac cag gaa ggg ggc ttt tgg cat ggc ttt gac atc tca      879
 Gln Gln Cys His Gln Glu Gly Gly Phe Trp His Gly Phe Asp Ile Ser
                 255                 260                 265

 ggt cac tcc ttc ctg ctg acc ttc tgc gcc ctc atg att gta gaa gag      927
 Gly His Ser Phe Leu Leu Thr Phe Cys Ala Leu Met Ile Val Glu Glu
             270                 275                 280

 atg tct gtg ctg cat gag gtg aag acg gac cga agc cac tgc ctc cac      975
 Met Ser Val Leu His Glu Val Lys Thr Asp Arg Ser His Cys Leu His
         285                 290                 295

 acc gcc atc acc acc ctg gtt gtg gcc ctg ggc att ctg act ttc atc     1023
 Thr Ala Ile Thr Thr Leu Val Val Ala Leu Gly Ile Leu Thr Phe Ile
     300                 305                 310

 tgg gtg ttg atg ttt ctg tgc aca gct gtt tat ttc cac aac ttg tcc     1071
 Trp Val Leu Met Phe Leu Cys Thr Ala Val Tyr Phe His Asn Leu Ser
 315                 320                 325                 330

 cag aag gtg ttt ggc acc ttg ttt ggt ttg ctg agc tgg tac ggg aca     1119
 Gln Lys Val Phe Gly Thr Leu Phe Gly Leu Leu Ser Trp Tyr Gly Thr
                 335                 340                 345

 tac ggg ttt tgg tat ccg aaa gcc ttt tcc cca gga ctt cct ccc cag     1167
 Tyr Gly Phe Trp Tyr Pro Lys Ala Phe Ser Pro Gly Leu Pro Pro Gln
             350                 355                 360

 agc tgt agt ttg aat ttg aag caa gat agt tac aag aaa taa aagagta     1216
 Ser Cys Ser Leu Asn Leu Lys Gln Asp Ser Tyr Lys Lys 
         365                 370                 375

 acagaggggg gacagaagga caatggctaa tctatttttc aaatatatat tttgcttagt   1276

 tatttggcta aattattgat cctacttcag agggaaagtg taccaggcag ttttggtggg   1336

 tggtgctgaa gtctggggag tgagtttagt cttcagacta ttcttggcga catcaccagt   1396

 gttgcaagca ccaccattcc cagttaggca ctttttgtcc ctggtaagac ttgaccttta   1456

 tctggaacac tccttttgtc cctagagtgg ggacctaagg ctcagcaaaa gggcagaatc   1516

 aggaaagcct ttatggtgtg gctaaaggag tggccagagc cttgggactc ctttgctgcc   1576

 ttctccctgg ttccagttgt ctttagattt tcacggctct tactgctgtt acttaacagt   1636

 attttc                                                              1642




      <210> 192
      <211> 1340
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (186)..(1289)

      <400> 192
 atttcttgtt atgagacaaa tgaagtattt cacattttcc attgaggata gcatgtaacg     60

 caggtttttc tcttataggt tgtgggactg gaaaatatct taaagtgaac agccaggtac    120

 ataccgtggg ctgtgactac tgtgggccac tggtagagat tgcccggaat agaggatgtg    180

 aagcc    atg gta tgt gac aac ctt aat ctc ccc ttt agg gat gag ggc     227
          Met Val Cys Asp Asn Leu Asn Leu Pro Phe Arg Asp Glu Gly
            1               5                  10

 ttc gat gcc atc atc tcc ata gga gtc ata cat cat ttt tct aca aaa      275
 Phe Asp Ala Ile Ile Ser Ile Gly Val Ile His His Phe Ser Thr Lys
  15                  20                  25                  30

 caa aga aga atc aga gca ata aaa gaa atg gcc agg gtc tta gtt ccc      323
 Gln Arg Arg Ile Arg Ala Ile Lys Glu Met Ala Arg Val Leu Val Pro
                  35                  40                  45

 gga ggc caa ctg atg att tac gtt tgg gca atg gaa caa aag aac cgt      371
 Gly Gly Gln Leu Met Ile Tyr Val Trp Ala Met Glu Gln Lys Asn Arg
              50                  55                  60

 cgc ttt gag aag caa gac gtg ctt gtt cca tgg aac agg gcc ctg tgt      419
 Arg Phe Glu Lys Gln Asp Val Leu Val Pro Trp Asn Arg Ala Leu Cys
          65                  70                  75

 tcc cag ctc ttc tca gag tcc agc cag tct ggg agg aag agg cag tgt      467
 Ser Gln Leu Phe Ser Glu Ser Ser Gln Ser Gly Arg Lys Arg Gln Cys
      80                  85                  90

 gga tac cca gaa aga ggc cat ccc tac cat cct cct tgc tct gag tgt      515
 Gly Tyr Pro Glu Arg Gly His Pro Tyr His Pro Pro Cys Ser Glu Cys
  95                 100                 105                 110

 agc tgt tct gtt tgt ttt aaa gag cag tgt ggt tca aaa cgg tcc cac      563
 Ser Cys Ser Val Cys Phe Lys Glu Gln Cys Gly Ser Lys Arg Ser His
                 115                 120                 125

 agc gtg ggc tat gaa act gct atg gca aga acc tgt ttt gca aat att      611
 Ser Val Gly Tyr Glu Thr Ala Met Ala Arg Thr Cys Phe Ala Asn Ile
             130                 135                 140

 tct aag gaa ggc gag gaa gaa tat gga ttt tac agc aca tta gga aaa      659
 Ser Lys Glu Gly Glu Glu Glu Tyr Gly Phe Tyr Ser Thr Leu Gly Lys
         145                 150                 155

 tcg ttt cgt tcc tgg ttt ttc tcc aga tct ttg gat gaa tcg act ctg      707
 Ser Phe Arg Ser Trp Phe Phe Ser Arg Ser Leu Asp Glu Ser Thr Leu
     160                 165                 170

 agg aag caa att gaa aga gta aga ccc ttg aaa aac aca gaa gtt tgg      755
 Arg Lys Gln Ile Glu Arg Val Arg Pro Leu Lys Asn Thr Glu Val Trp
 175                 180                 185                 190

 gcc agt agc act gta aca gtc cag cct tcc aga cac tct agt cta gac      803
 Ala Ser Ser Thr Val Thr Val Gln Pro Ser Arg His Ser Ser Leu Asp
                 195                 200                 205

 ttt gat cac caa gag cca ttt tca aca aaa gag caa agt tta gat gag      851
 Phe Asp His Gln Glu Pro Phe Ser Thr Lys Glu Gln Ser Leu Asp Glu
             210                 215                 220

 gaa gtg ttt gtg gaa tct tct tct gga aaa cac ttg gag tgg ctg aga      899
 Glu Val Phe Val Glu Ser Ser Ser Gly Lys His Leu Glu Trp Leu Arg
         225                 230                 235

 gca cca ggc act ctg aaa cat tta aat gga gac cat caa ggg gaa atg      947
 Ala Pro Gly Thr Leu Lys His Leu Asn Gly Asp His Gln Gly Glu Met
     240                 245                 250

 agg aga aat gga ggg gga aat ttt ctg gat agc act aat act ggt gtg      995
 Arg Arg Asn Gly Gly Gly Asn Phe Leu Asp Ser Thr Asn Thr Gly Val
 255                 260                 265                 270

 aat tgt gtg gat gca ggc aac ata gaa gat gat aat cct tct gct agt     1043
 Asn Cys Val Asp Ala Gly Asn Ile Glu Asp Asp Asn Pro Ser Ala Ser
                 275                 280                 285

 aaa ata ttg aga agg att tct gca gtc gat tcc aca gat ttc aac cca     1091
 Lys Ile Leu Arg Arg Ile Ser Ala Val Asp Ser Thr Asp Phe Asn Pro
             290                 295                 300

 gat gat aca atg tct gtc gaa gat cca cag act gat gtt ttg gac tcc     1139
 Asp Asp Thr Met Ser Val Glu Asp Pro Gln Thr Asp Val Leu Asp Ser
         305                 310                 315

 aca gcc ttt atg cgc tac tac cat gtg ttt cga gaa ggg gag ctc tgc     1187
 Thr Ala Phe Met Arg Tyr Tyr His Val Phe Arg Glu Gly Glu Leu Cys
     320                 325                 330

 agt ctg ctc aag gag aat gtg tca gag ctc cgt atc ctg agt tct ggg     1235
 Ser Leu Leu Lys Glu Asn Val Ser Glu Leu Arg Ile Leu Ser Ser Gly
 335                 340                 345                 350

 aat gat cat ggt aac tgg tgt atc att gca gag aaa aag aga ggt tgt     1283
 Asn Asp His Gly Asn Trp Cys Ile Ile Ala Glu Lys Lys Arg Gly Cys
                 355                 360                 365

 gat tga ttggatcctt ttagacaact cctccaaaag atgaaccaca ttcttttctc      1339
 Asp 


 t                                                                   1340




      <210> 193
      <211> 2264
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (670)..(1380)

      <400> 193
 gggaagctta ctactgccct ttgctctcct tcaggtcttt tcacttaaca ctttctacag     60

 ttatacttaa gtatttcaga caagagtaag caaatattac gcctggggtt cttctttcga    120

 gggtattttg gctggactgt cacccacgtt tggaatggaa agtgcagcac gagccgtaca    180

 ttttacattt ttcagcaacc acatcccatc actagccttt gaagtacaac gacacagctg    240

 tcttcatttt acaagtgcaa aaaccgaggt cctgcggggt gactgcccca gacgccgctg    300

 gtgacgggct gcgccgaggt cgagacgcca ggcttcaggt acacgtacca gaaatgacgt    360

 cacaggcggt gccaggcggg gatccacgag ctctggatgc ttgcttggcc ggaagcgacg    420

 ccccgcaagg acccgccccg cgccgccccg ccccgcgcga gccggtagtt gcgcctccca    480

 gactgcagtt ggccagctct cggggtgcgg agcccggcgg gctaggcgag gcgggcgctg    540

 gccccgcccc tcaggccggc gagtcccctt ctcagagact tggctaggcg cggcgcgagg    600

 cgggcgctgc gggtgagtcc cacttcccga cagcctggct cggccagcga ctgggcgggg    660

 agaccaagg    atg gaa gtg ggc tta ccg gcc att acc ctc ttt ctc acc     708
              Met Glu Val Gly Leu Pro Ala Ile Thr Leu Phe Leu Thr
                1               5                  10

 agc gcc agc agc cct gtg gtg gcg acg acg atg gac cag gag cca gtg      756
 Ser Ala Ser Ser Pro Val Val Ala Thr Thr Met Asp Gln Glu Pro Val
      15                  20                  25

 ggc ggt gtg gaa cga gga gaa gcc gtc gca gcc tcg gga gct gcg gcc      804
 Gly Gly Val Glu Arg Gly Glu Ala Val Ala Ala Ser Gly Ala Ala Ala
  30                  35                  40                  45

 gcc gcg gca ttc ggg gaa tct gca ggg cag atg agt aac gaa aga ggc      852
 Ala Ala Ala Phe Gly Glu Ser Ala Gly Gln Met Ser Asn Glu Arg Gly
                  50                  55                  60

 ttt gaa aat gta gaa ctg gga gtc ata gga aaa aag aag aaa gtc cca      900
 Phe Glu Asn Val Glu Leu Gly Val Ile Gly Lys Lys Lys Lys Val Pro
              65                  70                  75

 agg aga gtc atc cac ttt gtt agt ggt gaa aca atg gaa gaa tat agc      948
 Arg Arg Val Ile His Phe Val Ser Gly Glu Thr Met Glu Glu Tyr Ser
          80                  85                  90

 aca gat gaa gac gaa gtt gat ggc ctg gag aag aaa gat gtt ttg cct      996
 Thr Asp Glu Asp Glu Val Asp Gly Leu Glu Lys Lys Asp Val Leu Pro
      95                 100                 105

 act gtt gat ccg aca aaa ctt acc tgg ggt ccc tac tta tgg ttt tac     1044
 Thr Val Asp Pro Thr Lys Leu Thr Trp Gly Pro Tyr Leu Trp Phe Tyr
 110                 115                 120                 125

 atg ctt cgg gct gct aca tca act ctc tca gtg tgt gac ttc ctt gga     1092
 Met Leu Arg Ala Ala Thr Ser Thr Leu Ser Val Cys Asp Phe Leu Gly
                 130                 135                 140

 gag aag att gca tct gtt ttg ggt atc agc acc cca aag tac caa tat     1140
 Glu Lys Ile Ala Ser Val Leu Gly Ile Ser Thr Pro Lys Tyr Gln Tyr
             145                 150                 155

 gcc att gat gaa tat tat cgg atg aag aag gag gaa gaa gaa gaa gaa     1188
 Ala Ile Asp Glu Tyr Tyr Arg Met Lys Lys Glu Glu Glu Glu Glu Glu
         160                 165                 170

 gaa gaa aac agg atg tct gaa gaa gca gaa aaa caa tat caa cag aat     1236
 Glu Glu Asn Arg Met Ser Glu Glu Ala Glu Lys Gln Tyr Gln Gln Asn
     175                 180                 185

 aaa ttg cag act gat tcc att gtt cag aca gat caa cca gag aca gtg     1284
 Lys Leu Gln Thr Asp Ser Ile Val Gln Thr Asp Gln Pro Glu Thr Val
 190                 195                 200                 205

 ata tcc agc tca ttt gtg aat gtc aat ttt gaa atg gag gga gac agt     1332
 Ile Ser Ser Ser Phe Val Asn Val Asn Phe Glu Met Glu Gly Asp Ser
                 210                 215                 220

 gaa gta att atg gaa agc aag caa aat cca gtc tct gtc cca cca taa     1380
 Glu Val Ile Met Glu Ser Lys Gln Asn Pro Val Ser Val Pro Pro 
             225                 230                 235

 aatgaaatga ctatcaagct tcaaactctt aagttttttt tttttaatac aaaaactttc   1440

 acattcttta ttcagtggga cttaatacaa ttatttatat tttaaattat taaagtatct   1500

 ggaaagggaa aatgttttct tcatttttag gatctatcta gcaaaagcca gatctgaaat   1560

 tcagatattt gtactgtttt tactgtgtat agaaattagt gctttggttt taaaatgatc   1620

 ttttaaaaaa gttaaggaca tcctagagcc ttaatagtta agaagagtta aattatcaag   1680

 cctatttgtg catttgcttt ttttgaaaaa ggtaagttgc tgattaagtc taattggaat   1740

 tgataattcc atagtcttag attaaaatga ggatattttc tcctagattt tctcatgtta   1800

 tgccatgcat ttatatatct aaccattaat ttcacactaa ggatgcttca ccatataata   1860

 aaaggagcaa gatggaagca ctttgaattt tctttcattg agaataactg ttttatgtaa   1920

 gaatctgtat ttataacacc agatattaag ataggcttcc attttttaat gcaagccact   1980

 tacttaatct tgtattcttt ttcaggactc aaataactag ctttgaacat aatattaaaa   2040

 cactacttat agaatagatt tattaatgtt aatacctagt gaatatccat gtggcatcct   2100

 ggttatgtta tcggttcagc gttaatccta tagaaaagtg gtttggaggg gattggggga   2160

 tagtggcaaa ttttaaatta attcattaag ggcgatttaa attttttttt tggggcgggg   2220

 atagccttat aaaaattacc ccccagttct ttatttaaaa aggg                    2264




      <210> 194
      <211> 602
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (358)..(447)

      <400> 194
 cgcctcacct tcccacgcac gcagactcgc agacgccctc tgctggaact gacacgcaga     60

 cattcagcgg ctccgccgcc aatgcaaaac tcaaccctac cccaggcagc aatgctatcg    120

 cgtccgccgc gcccagctcc cccgcccgca atggtacgcg ccactccgcg ctccccgagc    180

 tggcgggctt gagggcgtag tgaatggaag gcgccgacgc cggaagtgga tgagaccact    240

 agggaggacg acgggtagca cgaacgcgcc gcgtctccat tgaggaaccg acgagaaaag    300

 aaatggttta cagatgaacc ggataatgcc tatcccagaa acattcaaat caagccc       357                                                                 
 atg agt acc cac atg gct aac cag atc aac caa tat aaa tcc aca agc      405
 Met Ser Thr His Met Ala Asn Gln Ile Asn Gln Tyr Lys Ser Thr Ser
   1               5                  10                  15

 agc ttg att cca cca atc aga gaa gtt gaa gat gaa tgt tga ctcccag      454
 Ser Leu Ile Pro Pro Ile Arg Glu Val Glu Asp Glu Cys 
              20                  25

 gagaccagaa ctattttttt aaagcctgac aaacttcata aatggtgatg tgacttttct    514

 tcttacatgc tgaatcactg gtggaaacgt taggataagc aagaattgcc agaaaataaa    574

 gtagacagat ctttcaaaaa aaaaaaaa                                       602




      <210> 195
      <211> 853
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (235)..(417)

      <400> 195
 aaataagatg acagaattaa ggccttatgc cacagccaga gttgaaaaat gcagaaaaaa     60

 agtttaaaaa caaggaatta aagccaaacc taacttttat caaaataaat gtaaaagtga    120

 tgaaagaatc tgttaagata tcagattgta atataaaaga tactagaaac aaatgccaat    180

 agaacactta agtacatttt atatattcat ccattagaat atatagctgt caga  atg     237
                                                              Met
                                                                1

 ata gaa gaa tta cat atg tgt gca aaa gtt ttt gta tcc atg tgg aaa      285
 Ile Glu Glu Leu His Met Cys Ala Lys Val Phe Val Ser Met Trp Lys
               5                  10                  15

 aca cag gaa gct aat agt act gtt ttt ctc tgg agt ggg tgt aag ggt      333
 Thr Gln Glu Ala Asn Ser Thr Val Phe Leu Trp Ser Gly Cys Lys Gly
          20                  25                  30

 aga gac tta act ctt tac atc ctt atg gca gcc ttc gaa tac ctt tta      381
 Arg Asp Leu Thr Leu Tyr Ile Leu Met Ala Ala Phe Glu Tyr Leu Leu
      35                  40                  45

 act ccc agt tcc ctt aac tgg ggg tgt gta tcc tag aatc ctcgacccat      431
 Thr Pro Ser Ser Leu Asn Trp Gly Cys Val Ser 
  50                  55                  60

 tagaaagtat attgtagaca tcatactctt taccctttaa cactacacat gcacttcata    491

 agaacaagca tgctgtctta cccaagtaca gctatcaagt tcagaaattt aacattgcca    551

 taatacttta cagtccatat ttcaatttca tttgctgttt tattggtaat ttttttcagc    611

 tccacgatcc agcctaggat catatgttgt attgccataa ccctctaatc tggagcagtt    671

 cctcagcttt tctttgtttt ttataatagt aatatatttg aaaaatacag gacagctaaa    731

 ggatagagta tccttctatt tgggtttttc tgatgtttcc tcatggttag attggggtag    791

 tgcagtgagg gttgaaatgc tgtaagtgat atgtattgca ggtatacatc cagatgcaca    851

 ga                                                                   853




      <210> 196
      <211> 1457
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (289)..(1284)

      <400> 196
 ttttaaaaga aatctatttt taatggcttt ggctttatag cacgaagcag gcaccctctc     60

 gttaaaggca cacagtcctc tcttctgccc cacctcctgg gtccttaaaa tcgagtccgg    120

 agttccagag gggtcactgc aaggcagcag ggaagggaga gggtcacagt ttcactctgt    180

 gagtatcaga cacccagggc caaggcccag actggcctct gaagctacag gttaacctgg    240

 gttccggaag ccggagagct ggagctttga agccaccccg gtcaaagg atg ctg agt     297
                                                      Met Leu Ser
                                                        1

 ccg gag cgc cta gcc cta ccg gac tac gag tat ctg gct cag cga cat      345
 Pro Glu Arg Leu Ala Leu Pro Asp Tyr Glu Tyr Leu Ala Gln Arg His
       5                  10                  15

 gtc ctc acc tac atg gag gat gca gtg tgc cag ctg cta gaa aac agg      393
 Val Leu Thr Tyr Met Glu Asp Ala Val Cys Gln Leu Leu Glu Asn Arg
  20                  25                  30                  35

 gaa gat att agc caa tat gga att gcc agg ttc ttc act gaa tat ttt      441
 Glu Asp Ile Ser Gln Tyr Gly Ile Ala Arg Phe Phe Thr Glu Tyr Phe
                  40                  45                  50

 aac agt gta tgc cag gga aca cac att ctc ttt cga gaa ttc agc ttc      489
 Asn Ser Val Cys Gln Gly Thr His Ile Leu Phe Arg Glu Phe Ser Phe
              55                  60                  65

 gtc caa gcc acc ccc cac aat agg gta tca ttt tta cgg gcc ttc tgg      537
 Val Gln Ala Thr Pro His Asn Arg Val Ser Phe Leu Arg Ala Phe Trp
          70                  75                  80

 aga tgc ttc cga act gtg ggc aaa aat ggc gat ttg ctg acc atg aaa      585
 Arg Cys Phe Arg Thr Val Gly Lys Asn Gly Asp Leu Leu Thr Met Lys
      85                  90                  95

 gaa tat cac tgt ttg ctg caa tta ctg tgt cct gat ttc ccg ctg gag      633
 Glu Tyr His Cys Leu Leu Gln Leu Leu Cys Pro Asp Phe Pro Leu Glu
 100                 105                 110                 115

 ctc act cag aaa gca gcc agg att gtg ctc atg gac gat gcc atg gac      681
 Leu Thr Gln Lys Ala Ala Arg Ile Val Leu Met Asp Asp Ala Met Asp
                 120                 125                 130

 tgc ttg atg tct ttt tca gat ttc ctc ttt gcc ttc cag atc cag ttt      729
 Cys Leu Met Ser Phe Ser Asp Phe Leu Phe Ala Phe Gln Ile Gln Phe
             135                 140                 145

 tac tac tca gaa ttc ctg gac agt gtg gct gcc atc tat gag gac ctg      777
 Tyr Tyr Ser Glu Phe Leu Asp Ser Val Ala Ala Ile Tyr Glu Asp Leu
         150                 155                 160

 ctg tca ggc aag aac ccc aac aca gtg att gtg ccg acg tcg tcc agt      825
 Leu Ser Gly Lys Asn Pro Asn Thr Val Ile Val Pro Thr Ser Ser Ser
     165                 170                 175

 ggg cag cac cgc caa cga cct gcc ttg ggc ggg gcc ggc acg ctg gag      873
 Gly Gln His Arg Gln Arg Pro Ala Leu Gly Gly Ala Gly Thr Leu Glu
 180                 185                 190                 195

 ggc gtg gag gcg tcg ctg ttc tac cag tgt ctg gaa aac ctg tgt gat      921
 Gly Val Glu Ala Ser Leu Phe Tyr Gln Cys Leu Glu Asn Leu Cys Asp
                 200                 205                 210

 cgg cac aag tac agc tgc cca ccc cca gca ctt gtc aaa gag gcc ctc      969
 Arg His Lys Tyr Ser Cys Pro Pro Pro Ala Leu Val Lys Glu Ala Leu
             215                 220                 225

 agc aat gtt cag aga ctg acc ttc tat gga ttc ctc atg gct ctc tca     1017
 Ser Asn Val Gln Arg Leu Thr Phe Tyr Gly Phe Leu Met Ala Leu Ser
         230                 235                 240

 aag cac cgt gga atc aac caa gcc ctc gga gct ttg cct gac aag ggg     1065
 Lys His Arg Gly Ile Asn Gln Ala Leu Gly Ala Leu Pro Asp Lys Gly
     245                 250                 255

 gat ctg atg cac gac cca gca atg gat gaa gag ctg gaa cgg ctg ctg     1113
 Asp Leu Met His Asp Pro Ala Met Asp Glu Glu Leu Glu Arg Leu Leu
 260                 265                 270                 275

 gcc cag gtc cca ggc ctg gtc aac tcg gtc aca gcc agt cca gag gcc     1161
 Ala Gln Val Pro Gly Leu Val Asn Ser Val Thr Ala Ser Pro Glu Ala
                 280                 285                 290

 agt tgc ctg cct tcc cgg acc cct ccc cgg gtt ggc tct ccc tgg aga     1209
 Ser Cys Leu Pro Ser Arg Thr Pro Pro Arg Val Gly Ser Pro Trp Arg
             295                 300                 305

 cct ctc cat cat tcc cga aaa gtg gat gga gag agt gat ggc tcc act     1257
 Pro Leu His His Ser Arg Lys Val Asp Gly Glu Ser Asp Gly Ser Thr
         310                 315                 320

 gaa gag aca gac gag tcg gag act tga ggagt ccaaagggtc ctgcccacag     1309
 Glu Glu Thr Asp Glu Ser Glu Thr 
     325                 330

 cgccctgtac ctgctcccac ccagcccttg gtgtgcccac ccagcctcct ctccagcacc   1369

 ttgctgtgct gccctctgct gctgacaagg tgaataacag ccccaagacc agccagaggg   1429

 gctctgatga tcagcccagc cagtggcc                                      1457




      <210> 197
      <211> 656
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (390)..(629)

      <400> 197
 ggaattcggc ctgggccggg gtcggcggcg cccccggggc tggaggcggc ccggcagaag     60

 ctggcgctgc ggggcaagaa ggtgctgagc accgaggaga tggagctgta cgagctggct    120

 caggcggcgg gcggcggtat cgaccccgac gtgttcaaga tcctggtgga cctgctgaag    180

 ctgaacgtgg cccccctcgc cgtcttccag atgctcaagt ccatgtgtgc cgggcagagg    240

 ctagcgagcg agccccagga ccctgcggcc gtgtctctgc ccacgtcgag cgtgcccgag    300

 acccgaggct tgagtgacaa cttgaggaca aggcggcgcc tcgacaagat ttcacacagc    360

 agctacgggg gccagagaag cagcaccgc  atg gtg tgg cag gag aag gag gac     413
                                  Met Val Trp Gln Glu Lys Glu Asp
                                    1               5

 atg cac aag caa ttg gtt gaa gct tca gag aca ttg aaa tcc caa gcc      461
 Met His Lys Gln Leu Val Glu Ala Ser Glu Thr Leu Lys Ser Gln Ala
      10                  15                  20

 aaa gaa ctg aaa gat gcc cat cag cag caa aag ctg gcc ctg cag gag      509
 Lys Glu Leu Lys Asp Ala His Gln Gln Gln Lys Leu Ala Leu Gln Glu
  25                  30                  35                  40

 ttc ttg gag ctc aat gag ctc atg gca gag ctc tac tcc cag aag cag      557
 Phe Leu Glu Leu Asn Glu Leu Met Ala Glu Leu Tyr Ser Gln Lys Gln
                  45                  50                  55

 aag gtg tgg gac aag gag gag gag atg gaa gta gcc atg cag aaa gct      605
 Lys Val Trp Asp Lys Glu Glu Glu Met Glu Val Ala Met Gln Lys Ala
              60                  65                  70

 gac atg atg tgg cag gag atc tga agatccaaga agctcagaaa gaggatg        656
 Asp Met Met Trp Gln Glu Ile 
          75





      <210> 198
      <211> 709
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (224)..(673)

      <400> 198
 cgaggcctgc ccagtgtgtg ggtaccactt gttcaaacca gtcttatacc ctttccaatc     60

 ttagcagacc agcgccttct aaatacttcc tttacttagt ttgtggacag cagctcctta    120

 acattcagcc aaaataccac cgtccacagt cctcataatc tacaaaatct cctttcctcc    180

 caagcattaa gctcccttcc tccttcccgg attcaattac tcc  atg ccc tct tta     235
                                                  Met Pro Ser Leu
                                                    1

 tca aaa atc ctg aat tca agt ctt gcc aaa agt gct cct ctc aac cca      283
 Ser Lys Ile Leu Asn Ser Ser Leu Ala Lys Ser Ala Pro Leu Asn Pro
   5                  10                  15                  20

 gca tcc tta ctc ccc gta tcc tct tcc cct cct act cat tct tgc act      331
 Ala Ser Leu Leu Pro Val Ser Ser Ser Pro Pro Thr His Ser Cys Thr
                  25                  30                  35

 gac atc ctg gat cac ctg cag cca cac ttt cca aac att tcc tcc gag      379
 Asp Ile Leu Asp His Leu Gln Pro His Phe Pro Asn Ile Ser Ser Glu
              40                  45                  50

 cct ctc acc aac ccc gat gac cag cta ttt ata gat ggc tcc tct tct      427
 Pro Leu Thr Asn Pro Asp Asp Gln Leu Phe Ile Asp Gly Ser Ser Ser
          55                  60                  65

 ggg ccc act ggc cct ccg aaa att gtt ggc att cag ctc aag tct cct      475
 Gly Pro Thr Gly Pro Pro Lys Ile Val Gly Ile Gln Leu Lys Ser Pro
      70                  75                  80

 aca cca tct cac cca gtt ttt aca gga ccg tat cag agc ctt cac ccg      523
 Thr Pro Ser His Pro Val Phe Thr Gly Pro Tyr Gln Ser Leu His Pro
  85                  90                  95                 100

 ctg gac aat aca aga tat aat gct gct cca gga ata cca atg gct cca      571
 Leu Asp Asn Thr Arg Tyr Asn Ala Ala Pro Gly Ile Pro Met Ala Pro
                 105                 110                 115

 aaa act gta gtc cct act gtc cag cct tcc ccc aca acc gtc gcc cct      619
 Lys Thr Val Val Pro Thr Val Gln Pro Ser Pro Thr Thr Val Ala Pro
             120                 125                 130

 tcc cag caa gaa gca gcc aaa cga caa tgg cac ccc tct tct att acc      667
 Ser Gln Gln Glu Ala Ala Lys Arg Gln Trp His Pro Ser Ser Ile Thr
         135                 140                 145

 tat taa agggctggaa tgttagggac aaactgccca agaaag                      709
 Tyr 






      <210> 199
      <211> 381
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (185)..(334)

      <400> 199
 cgcataaaca cacccacaga accacaagtt gggtagcctg gcagtgtcag aagtctgaac     60

 ccagcatagt ggtcagcagg caggacgaat cacactgaat gcaaaccaca gggtttcgca    120

 gcgtggtaaa agaaatcatt gagtcccccg ccttcagaag agggtgcatt ttcaggagga    180

 agcg atg gct tca gac agc ata ttt gag tca ttt cct tcg tac cca cag     229
      Met Ala Ser Asp Ser Ile Phe Glu Ser Phe Pro Ser Tyr Pro Gln
        1               5                  10                  15

 tgc ttc atg aga gct cta aga gac tct gcg aag aga cac att gct ttg      277
 Cys Phe Met Arg Ala Leu Arg Asp Ser Ala Lys Arg His Ile Ala Leu
                  20                  25                  30

 gag gaa tca gcc cca ggc caa agc aac aag caa cac cag agt cct gcg      325
 Glu Glu Ser Ala Pro Gly Gln Ser Asn Lys Gln His Gln Ser Pro Ala
              35                  40                  45

 gag agc tga gaagcaa ctcgcccact cagacataga cacacagatg gacaaactgg      381
 Glu Ser 






      <210> 200
      <211> 1413
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (269)..(1108)

      <400> 200
 atggaacata aaatatagac ctgtatgcat gcatcttgct ggacccggag atcatcatta     60

 ctggagtcga cgaacgctaa tggcccgtcc tatgattaac gaagccccag tggcttattt    120

 attggtagaa aaccctaatt gatgacgtca tactattcac agaagaagaa atgatactgg    180

 tgcacagata tagagatatg tccaacgttg ctggaaaccc aaggaccaag taaggtccag    240

 cttaaaaaat gtgtccgacc tttttgtg   atg gga gga gct ctt gtt tta gaa     292
                                  Met Gly Gly Ala Leu Val Leu Glu
                                    1               5

 tct gca gct ctc ttg cac tgg cta gag agg gaa ggt tac ggc cct tta      340
 Ser Ala Ala Leu Leu His Trp Leu Glu Arg Glu Gly Tyr Gly Pro Leu
      10                  15                  20

 gga atg act gga ata tcc atg gga gga cac atg gct tcc tta gcg gta      388
 Gly Met Thr Gly Ile Ser Met Gly Gly His Met Ala Ser Leu Ala Val
  25                  30                  35                  40

 tcc aac tgg cct aag ccc atg cca ttg att cca tgc ctg tct tgg tcc      436
 Ser Asn Trp Pro Lys Pro Met Pro Leu Ile Pro Cys Leu Ser Trp Ser
                  45                  50                  55

 aca gca tct ggg gtc ttc act acg ggt gtg ttg agt aaa tca att aat      484
 Thr Ala Ser Gly Val Phe Thr Thr Gly Val Leu Ser Lys Ser Ile Asn
              60                  65                  70

 tgg agg gag ctg gaa aag caa tat tat acc cag aca gtt tat gaa gaa      532
 Trp Arg Glu Leu Glu Lys Gln Tyr Tyr Thr Gln Thr Val Tyr Glu Glu
          75                  80                  85

 gaa att att cac atg ctt gaa tac tgt gga aca gat tct ttc aaa atg      580
 Glu Ile Ile His Met Leu Glu Tyr Cys Gly Thr Asp Ser Phe Lys Met
      90                  95                 100

 gga caa gag ttt gtg aaa cac ttc act agc agt gca gac aag cta act      628
 Gly Gln Glu Phe Val Lys His Phe Thr Ser Ser Ala Asp Lys Leu Thr
 105                 110                 115                 120

 aac ctt aat ctg gtt tcc aga act tta aat tta gat ata tca aac caa      676
 Asn Leu Asn Leu Val Ser Arg Thr Leu Asn Leu Asp Ile Ser Asn Gln
                 125                 130                 135

 gtt gta tcc caa aaa cct gct gac tgc cat aat tct agc aaa aca tct      724
 Val Val Ser Gln Lys Pro Ala Asp Cys His Asn Ser Ser Lys Thr Ser
             140                 145                 150

 gtc agt gcg aca tca gaa gga ctc tta ttg caa gat acc tct aag atg      772
 Val Ser Ala Thr Ser Glu Gly Leu Leu Leu Gln Asp Thr Ser Lys Met
         155                 160                 165

 aag cgc ttc aat caa aca ctt tca acc aac aaa agt ggt tat aca agt      820
 Lys Arg Phe Asn Gln Thr Leu Ser Thr Asn Lys Ser Gly Tyr Thr Ser
     170                 175                 180

 cgc aac cct cag tca tac cac cta ctt agt aaa gaa caa agc aga aac      868
 Arg Asn Pro Gln Ser Tyr His Leu Leu Ser Lys Glu Gln Ser Arg Asn
 185                 190                 195                 200

 agt ctt cgg aaa gag tct tta ata ttt atg aaa gga gtc atg gat gaa      916
 Ser Leu Arg Lys Glu Ser Leu Ile Phe Met Lys Gly Val Met Asp Glu
                 205                 210                 215

 tgt act cat gta gca aat ttc tca gtc cca gtt gat cca agc ctc att      964
 Cys Thr His Val Ala Asn Phe Ser Val Pro Val Asp Pro Ser Leu Ile
             220                 225                 230

 ata gtg gtt caa gcc aaa gaa gat gcc tat att cca cga aca gga gtt     1012
 Ile Val Val Gln Ala Lys Glu Asp Ala Tyr Ile Pro Arg Thr Gly Val
         235                 240                 245

 cga agt tta caa gaa att tgg cct ggt tgt gaa atc cga tac tta gaa     1060
 Arg Ser Leu Gln Glu Ile Trp Pro Gly Cys Glu Ile Arg Tyr Leu Glu
     250                 255                 260

 ggg ggt cat att agt gct tat ctt ttt aaa caa gga ctc ttc agg taa     1108
 Gly Gly His Ile Ser Ala Tyr Leu Phe Lys Gln Gly Leu Phe Arg 
 265                 270                 275

 gacggctggt ctaaacatgt attcgttcat ttgttgtttg ttttctggat tttttgcttc   1168

 aacaaatgta aaagatcaca tatttttata gtctgtttca atctttgaat tccctcctca   1228

 cctcccacaa atctcacaga gttacttttc cctctttcct agaatttgat cttcttattt   1288

 tcttctagag aactaagcat gatgcatatt ataggcatgc tttatcgtgt ggctttcccc   1348

 tcttcaaata ttaatggcca ggtattttag gatgtgagaa ggaagatcat ggcttgttaa   1408

 agttt                                                               1413




      <210> 201
      <211> 681
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(630)

      <400> 201
  atg acc aaa caa tcc agc aat cct acc tct gag tat gcg tct gaa gga      48
  Met Thr Lys Gln Ser Ser Asn Pro Thr Ser Glu Tyr Ala Ser Glu Gly
    1               5                  10                  15

 aat ggg tat ttc caa gag cta tct gca ctc cca cgc ttg ctg cag tgt       96
 Asn Gly Tyr Phe Gln Glu Leu Ser Ala Leu Pro Arg Leu Leu Gln Cys
              20                  25                  30

 tat tcg cat cag cca agg cac gtc agc cgt atg agg gtc ctt cat gat      144
 Tyr Ser His Gln Pro Arg His Val Ser Arg Met Arg Val Leu His Asp
          35                  40                  45

 gca cgg ata aac aca ctt gat ttc atc ctg atc ctg gag gct gtc aag      192
 Ala Arg Ile Asn Thr Leu Asp Phe Ile Leu Ile Leu Glu Ala Val Lys
      50                  55                  60

 aag aga tca ttc ctg gag act gtc aag aag aga tca cgt caa gaa gag      240
 Lys Arg Ser Phe Leu Glu Thr Val Lys Lys Arg Ser Arg Gln Glu Glu
  65                  70                  75                  80

 aca tcc aaa agg atg tct cct tct gga gac agc cac att caa tca aca      288
 Thr Ser Lys Arg Met Ser Pro Ser Gly Asp Ser His Ile Gln Ser Thr
                  85                  90                  95

 aat tcc cta aac aac att gat gga tca aga ggg gaa aca agg aaa gtt      336
 Asn Ser Leu Asn Asn Ile Asp Gly Ser Arg Gly Glu Thr Arg Lys Val
             100                 105                 110

 gtc agg gga gtg tcc att ggc agc acc tgc ctc ctg agt gtc tcc cag      384
 Val Arg Gly Val Ser Ile Gly Ser Thr Cys Leu Leu Ser Val Ser Gln
         115                 120                 125

 gcc atc acc atc agc ccc agg agc tca ggt ggg cag agc tta aag gga      432
 Ala Ile Thr Ile Ser Pro Arg Ser Ser Gly Gly Gln Ser Leu Lys Gly
     130                 135                 140

 acg ccc cca agc acg ctg gct cct gtg tgt tcc tca gct ggc tcc tcc      480
 Thr Pro Pro Ser Thr Leu Ala Pro Val Cys Ser Ser Ala Gly Ser Ser
 145                 150                 155                 160

 ctg gtc aat atc att gtt ctc atg cac gtg acc ggc aag tgg agc aac      528
 Leu Val Asn Ile Ile Val Leu Met His Val Thr Gly Lys Trp Ser Asn
                 165                 170                 175

 aaa aat acc aca aag aca aaa gat ctg gga tac tgt tct gct gct gat      576
 Lys Asn Thr Thr Lys Thr Lys Asp Leu Gly Tyr Cys Ser Ala Ala Asp
             180                 185                 190

 cac gag ggc acc aga gag tcg ctg acg cgg cac tgc tgt cct tcc ctg      624
 His Glu Gly Thr Arg Glu Ser Leu Thr Arg His Cys Cys Pro Ser Leu
         195                 200                 205

 atg tga tctgcctggg gctcatgctc tggggcagca gctccatcgt ttgcatcctg       680
 Met 


 c                                                                    681




      <210> 202
      <211> 683
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (122)..(352)

      <400> 202
 attcatacgt gtacatttct acttcagttt ttattatcca ttacataaca tacatgcttg     60

 attatttgct tcaaggaaat acacctttat aagtaatact caataactac tgggtttgag    120

 a    atg aag gtg tca gaa cga atg aga ttg tcc tat gaa aga aga ggc     166
      Met Lys Val Ser Glu Arg Met Arg Leu Ser Tyr Glu Arg Arg Gly
        1               5                  10                  15

 agg agc cag gga gga gga tcc cac ccg gcc ggg gct cag cca gga ggc      214
 Arg Ser Gln Gly Gly Gly Ser His Pro Ala Gly Ala Gln Pro Gly Gly
                  20                  25                  30

 agg gcc att ggg gca ggg tgg cag tcc aag gaa ccg ctc tgg gaa ggt      262
 Arg Ala Ile Gly Ala Gly Trp Gln Ser Lys Glu Pro Leu Trp Glu Gly
              35                  40                  45

 ttg caa agg tcg ggg tcc ccc ctg cca ggt gat cga att atc gtg gag      310
 Leu Gln Arg Ser Gly Ser Pro Leu Pro Gly Asp Arg Ile Ile Val Glu
          50                  55                  60

 tgt ctg gaa ggc ggg gga agt ttt gtt gag ttc acc aaa taa ctcagac      359
 Cys Leu Glu Gly Gly Gly Ser Phe Val Glu Phe Thr Lys 
      65                  70                  75

 caactggaaa ccaagtggag tttctacagg accaactaga atagggatca gctacatggg    419

 ggcgggggga ggggggcagg gaacggtgtc tgtcttcatt gcagctctgt ctgcagagcc    479

 agcactgtga tacctcatag taggtgctca gtgaatgtct gtgaagtgaa ttactatcta    539

 gacaaggatg agactggtat gactctccaa agctttccca cctccaaaac ctcggcttgt    599

 ggggaatctc cagtaggggg cactgtggac acggttcgca tctgcctccc aaggctgggc    659

 tccgcgtcaa aaaaaaaaaa aaaa                                           683




      <210> 203
      <211> 746
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (323)..(532)

      <400> 203
 cccttccttg ctgacctctg cctgctgtaa gggcctagct gtgggcacag ggagaattgg     60

 ggttgagctg gtgtgcccta tggcattttg gggagaggca gggtggcagc catccttgcc    120

 ctgggctggc agcgccatgg tgcctttgat gagcagcagc aggactggcc tctcagccat    180

 cccctagcca ggtgctgaga ctgctttgga atggagattt aatcccctgg aggtctccca    240

 gcagccatgg gttggggcag caggcctgtg ggaagggaag attgacggcc tcacctcatc    300

 cttgcccctg ggcagatatg gc atg tca gtc tgg tgg tct agc cag agg aag     352
                          Met Ser Val Trp Trp Ser Ser Gln Arg Lys
                            1               5                  10

 act cct gga gct ggt gaa ctg tgc atg gat atg cag tca cgg gca gcc      400
 Thr Pro Gly Ala Gly Glu Leu Cys Met Asp Met Gln Ser Arg Ala Ala
                  15                  20                  25

 cac ctc cta ctc ctc acc ctc cct gtg cct gtg agg gtc tgc act cac      448
 His Leu Leu Leu Leu Thr Leu Pro Val Pro Val Arg Val Cys Thr His
              30                  35                  40

 cct gat tcc gtg agt cag gag ctt ggc cag gct cag ctg gga cac tca      496
 Pro Asp Ser Val Ser Gln Glu Leu Gly Gln Ala Gln Leu Gly His Ser
          45                  50                  55

 tct ttg ctt cac ctc atg tca gct gca gca tct tag gaat gcaagacagc      546
 Ser Leu Leu His Leu Met Ser Ala Ala Ala Ser 
      60                  65

 ctcattcaca tccggcggcg ggtgctggct gtccactggg tgccttcgct ctttttcaag    606

 aggattctca tcctctgggg tttcactgtc tccatgtggc ctccctagca agttgcttag    666

 atttctttac gtggaaactg gctttctaga gggtaaaaat ggaagctgca aggactctta    726

 tggcccagaa gtcccagaac                                                746




      <210> 204
      <211> 848
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (251)..(724)

      <400> 204
 aacaaccccg aggtcttatt tttatagaat atcaagaaca aaatcttcca aaaggcacac     60

 gatgccaaac taaaaataaa gagcgaaaac ccaaaaagtc gcgctcaatt ccttctgaaa    120

 cctattcgcc tcctacccct gtcccatcct ctggcgctgg cgggtcctcg tccccgtttt    180

 ccccaccgca agtcctggaa cctccgctta actcttttct cggcggctcc gccccggccc    240

 cgccccagcc   atg cct tgg ccc cgc ccc gtt cgc cgt tta ttg gct tct     289
              Met Pro Trp Pro Arg Pro Val Arg Arg Leu Leu Ala Ser
                1               5                  10

 ccc aac ccc tgc cgg tgg gtg aca agc cgg gaa gct tgg agg ggt cta      337
 Pro Asn Pro Cys Arg Trp Val Thr Ser Arg Glu Ala Trp Arg Gly Leu
      15                  20                  25

 ttg cgt acg ccc aag gcg ctg ggc ctg gag cag gag aaa ggg agt gga      385
 Leu Arg Thr Pro Lys Ala Leu Gly Leu Glu Gln Glu Lys Gly Ser Gly
  30                  35                  40                  45

 ggc gcg tcg gag act atg aag cgc ggc att cgg cgg gat cct ttc cgg      433
 Gly Ala Ser Glu Thr Met Lys Arg Gly Ile Arg Arg Asp Pro Phe Arg
                  50                  55                  60

 aag cgg aag ctc ggc ggg cgg gcc aag aag gtc cgg gag ccc acg gcg      481
 Lys Arg Lys Leu Gly Gly Arg Ala Lys Lys Val Arg Glu Pro Thr Ala
              65                  70                  75

 gtt aat tct ttt tac cgt gag gct tca ctt ccc tcg gtc tgg gct tct      529
 Val Asn Ser Phe Tyr Arg Glu Ala Ser Leu Pro Ser Val Trp Ala Ser
          80                  85                  90

 ctg agg cgg cga gag atg gtc agg tct gga gct cga ccg ggc cag gtg      577
 Leu Arg Arg Arg Glu Met Val Arg Ser Gly Ala Arg Pro Gly Gln Val
      95                 100                 105

 agg gct gag gac ctg agg agt ccg ctg tgg gga tgg aga ggg aca ggg      625
 Arg Ala Glu Asp Leu Arg Ser Pro Leu Trp Gly Trp Arg Gly Thr Gly
 110                 115                 120                 125

 ggg ttt tcg ggc cag gaa ctt gta aaa ctc tgc tcg aaa aaa gac aaa      673
 Gly Phe Ser Gly Gln Glu Leu Val Lys Leu Cys Ser Lys Lys Asp Lys
                 130                 135                 140

 gac aat gcg gcg aca tta aag tgc tgg gac aga ggt gca ggg aac acc      721
 Asp Asn Ala Ala Thr Leu Lys Cys Trp Asp Arg Gly Ala Gly Asn Thr
             145                 150                 155

 taa tctt cccgtcgtaa cacggccgct cggtctctag atgtttctgt ttaaatcgtc      778
 


 gtagccctag tctagagcgc cggctttggg gtcaggcccg ggttcgagtc ccagccttcg    838

 acggtgagta                                                           848




      <210> 205
      <211> 1534
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (288)..(1205)

      <220>
      <221> misc_feature
      <222> (1)...(1534)
      <223> n = a,t,c or g

      <400> 205
 tcgagcaaga gattcggcac gagggaaact ttgaataata gacaccagaa gatgtgagaa     60

 cagctaccta gtgtgtgttg cattattaac ccctagtttg tagtgtattc tggagtcaag    120

 ttgacctaca tagaagagaa ggaactggaa gtgcatgtaa cccgcctggc tccgattggg    180

 aaaagctgct taaccactgt tacacttcca ggggctcccc actcagtccc cagtcatcta    240

 tcgacagtga gctgagtact tcagaattgg aggatgattc tatctcc  atg gga tat     296
                                                      Met Gly Tyr
                                                        1

 aaa tta cag gac ctc act gat gtt cag atc atg gct cgt ctg caa gaa      344
 Lys Leu Gln Asp Leu Thr Asp Val Gln Ile Met Ala Arg Leu Gln Glu
       5                  10                  15

 gaa agt ctc agg caa gat tat gct tct act tca gca tct gta tca aga      392
 Glu Ser Leu Arg Gln Asp Tyr Ala Ser Thr Ser Ala Ser Val Ser Arg
  20                  25                  30                  35

 cat agt tcc agt gtg tca ttg agt tca gga aaa aaa ggg aca tgt agt      440
 His Ser Ser Ser Val Ser Leu Ser Ser Gly Lys Lys Gly Thr Cys Ser
                  40                  45                  50

 gat caa gaa tat gac caa tac agt ctg gag gat gaa gag gaa ttt gat      488
 Asp Gln Glu Tyr Asp Gln Tyr Ser Leu Glu Asp Glu Glu Glu Phe Asp
              55                  60                  65

 cat ttg cca cca cct cag cct cgt ctt cca aga tgt tcc cct ttc caa      536
 His Leu Pro Pro Pro Gln Pro Arg Leu Pro Arg Cys Ser Pro Phe Gln
          70                  75                  80

 aga gga att ccc cat tca cag act ttc tcc agc att cgg gag tgt agg      584
 Arg Gly Ile Pro His Ser Gln Thr Phe Ser Ser Ile Arg Glu Cys Arg
      85                  90                  95

 agg agc ccc agt tcc cag tat ttt cct tca aat aat tac cag cag caa      632
 Arg Ser Pro Ser Ser Gln Tyr Phe Pro Ser Asn Asn Tyr Gln Gln Gln
 100                 105                 110                 115

 cag tat tat tca cct caa gcc caa act cca gat cag caa cca aat agg      680
 Gln Tyr Tyr Ser Pro Gln Ala Gln Thr Pro Asp Gln Gln Pro Asn Arg
                 120                 125                 130

 acc aat gga gat aag ctc cga aga agt atg cct aac cta gcc cgg atg      728
 Thr Asn Gly Asp Lys Leu Arg Arg Ser Met Pro Asn Leu Ala Arg Met
             135                 140                 145

 cca agt aca act gcc att agt agc aac att agt tct ccg gtc acc gtg      776
 Pro Ser Thr Thr Ala Ile Ser Ser Asn Ile Ser Ser Pro Val Thr Val
         150                 155                 160

 cga aat agt cag agt ttt gac tca agc ttg cat gga gct gga aat gga      824
 Arg Asn Ser Gln Ser Phe Asp Ser Ser Leu His Gly Ala Gly Asn Gly
     165                 170                 175

 att tca aga ata caa tct tgt att cca tca ccg gga cag ctt caa cac      872
 Ile Ser Arg Ile Gln Ser Cys Ile Pro Ser Pro Gly Gln Leu Gln His
 180                 185                 190                 195

 agg gtc cac agc gtg ggg cat ttc cca gtg tct atc cga cag cct ctt      920
 Arg Val His Ser Val Gly His Phe Pro Val Ser Ile Arg Gln Pro Leu
                 200                 205                 210

 aaa gcc aca gcc tat gtg agt cca acc gtt caa ggc agc agt aac atg      968
 Lys Ala Thr Ala Tyr Val Ser Pro Thr Val Gln Gly Ser Ser Asn Met
             215                 220                 225

 cct tta tca aac ggc tta cag ctg tat tcc aac aca gga atc ccc aca     1016
 Pro Leu Ser Asn Gly Leu Gln Leu Tyr Ser Asn Thr Gly Ile Pro Thr
         230                 235                 240

 ccg aac aaa gct gca gct tct ggg ata atg ggt cgc agt gca ctc cca     1064
 Pro Asn Lys Ala Ala Ala Ser Gly Ile Met Gly Arg Ser Ala Leu Pro
     245                 250                 255

 aga cct tcg ttg gca ata aat ggg agt aac ctg cct cga agc aaa att     1112
 Arg Pro Ser Leu Ala Ile Asn Gly Ser Asn Leu Pro Arg Ser Lys Ile
 260                 265                 270                 275

 gca caa cct gtt aga agt ttt ctt cag cct cca aag cct ctg tct tca     1160
 Ala Gln Pro Val Arg Ser Phe Leu Gln Pro Pro Lys Pro Leu Ser Ser
                 280                 285                 290

 ctc agc act ctg agg gat gga aat tgg aga gat ggt tgc tac taa tgc     1208
 Leu Ser Thr Leu Arg Asp Gly Asn Trp Arg Asp Gly Cys Tyr 
             295                 300                 305

 agttttatgt acccttgaaa aatgggaaag aagtactttc ccttttgtgt tttaatatat   1268

 ttactgcatt gtttctcaat ggaccagtca ccagagacta attattgcac ttaaatattt   1328

 gcctgagata ctgcaacatt ctcaaaccca tggttgcagt attgtgacac ttagatctag   1388

 gaagtttttg tagaactgct ctgtacctga atactttntg agagaattaa gatgtatcaa   1448

 taatgctttg ccatatgagt tttttaaagt aacttgttca atttactcac gtgttctaaa   1508

 catctttcca ttacatgttc tgtatt                                        1534




      <210> 206
      <211> 2079
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (173)..(1543)

      <400> 206
 agcttggcgc gccagtgcct cggtttccag gctccgggaa taacagaagc cagctgagag     60

 cgcctgcgcg gctgtcggtt gatggggagg tcaggtctgg gaaactaggc cctggggttt    120

 tccctgagca ggagcggtgc ccgagggcct caggcgtcag tccaggccct ga    atg     175
                                                              Met
                                                                1

 gct ggt ctc cag cgg ttg gcg tca cat ctg cct gtg ggc gtt atg ctc      223
 Ala Gly Leu Gln Arg Leu Ala Ser His Leu Pro Val Gly Val Met Leu
               5                  10                  15

 cca cat aat aca acg gaa gct cca ggg ccc cac tca gcc aag caa gac      271
 Pro His Asn Thr Thr Glu Ala Pro Gly Pro His Ser Ala Lys Gln Asp
          20                  25                  30

 tct tat gaa caa ggt gac tct tcc cag cag tcc ttg aag ggg cac ctg      319
 Ser Tyr Glu Gln Gly Asp Ser Ser Gln Gln Ser Leu Lys Gly His Leu
      35                  40                  45

 agg aac aat ttc cag aag cag ctt ttg agc aac aaa gag ttg att ctg      367
 Arg Asn Asn Phe Gln Lys Gln Leu Leu Ser Asn Lys Glu Leu Ile Leu
  50                  55                  60                  65

 gat aaa gtc tat act cac ccc aaa tgg aac acc caa aca aaa gcc cgg      415
 Asp Lys Val Tyr Thr His Pro Lys Trp Asn Thr Gln Thr Lys Ala Arg
                  70                  75                  80

 agc tac tcc tat ccc cac tgt act gga atc agc cag caa gat cca gaa      463
 Ser Tyr Ser Tyr Pro His Cys Thr Gly Ile Ser Gln Gln Asp Pro Glu
              85                  90                  95

 agt gat tcc cag ggc caa gga aat ggt ttg ttt tac tcg tca ggc cct      511
 Ser Asp Ser Gln Gly Gln Gly Asn Gly Leu Phe Tyr Ser Ser Gly Pro
         100                 105                 110

 caa tcc tgg tat ccc aaa gcc aat aac cag gac ttt atc ccc ttt aca      559
 Gln Ser Trp Tyr Pro Lys Ala Asn Asn Gln Asp Phe Ile Pro Phe Thr
     115                 120                 125

 aag aaa cga gtt gga gtg gac cgg gcg ttc cca ttg aaa ccc atg gtc      607
 Lys Lys Arg Val Gly Val Asp Arg Ala Phe Pro Leu Lys Pro Met Val
 130                 135                 140                 145

 cac agg aag tcg tgc agt aca ggt gag gct ggc act gat ggg gac cat      655
 His Arg Lys Ser Cys Ser Thr Gly Glu Ala Gly Thr Asp Gly Asp His
                 150                 155                 160

 aat gtc tac cca agg ccc cct gag ccg aga gag ttt tca tct agg aac      703
 Asn Val Tyr Pro Arg Pro Pro Glu Pro Arg Glu Phe Ser Ser Arg Asn
             165                 170                 175

 ttt ggt gtg agg aac cag ggc aac ttt tct gtg gtt ggt act gtt ctt      751
 Phe Gly Val Arg Asn Gln Gly Asn Phe Ser Val Val Gly Thr Val Leu
         180                 185                 190

 gct gcc acg cag gcg gag aag gcc gtg gca aac ttt gac agg acg gag      799
 Ala Ala Thr Gln Ala Glu Lys Ala Val Ala Asn Phe Asp Arg Thr Glu
     195                 200                 205

 tgg gtg cag atc cga aga cta gaa gct gca ggg gag agc tta gag gag      847
 Trp Val Gln Ile Arg Arg Leu Glu Ala Ala Gly Glu Ser Leu Glu Glu
 210                 215                 220                 225

 gaa atc cga aga aag cag att ctc ctg agg gga aag ctg aag aag aca      895
 Glu Ile Arg Arg Lys Gln Ile Leu Leu Arg Gly Lys Leu Lys Lys Thr
                 230                 235                 240

 gag gag gaa ctc aga agg atc cag acg caa aag gaa cag gcc aag gaa      943
 Glu Glu Glu Leu Arg Arg Ile Gln Thr Gln Lys Glu Gln Ala Lys Glu
             245                 250                 255

 aat gaa aac gga gag cta cag aaa att ata ctc ccc agg agc aga gtt      991
 Asn Glu Asn Gly Glu Leu Gln Lys Ile Ile Leu Pro Arg Ser Arg Val
         260                 265                 270

 aaa ggt aat aaa agc aac acc atg tac aaa cct atc ttc tcc cca gaa     1039
 Lys Gly Asn Lys Ser Asn Thr Met Tyr Lys Pro Ile Phe Ser Pro Glu
     275                 280                 285

 ttt gag ttt gag gaa gaa ttt agt aga gac agg aga gag gat gaa act     1087
 Phe Glu Phe Glu Glu Glu Phe Ser Arg Asp Arg Arg Glu Asp Glu Thr
 290                 295                 300                 305

 tgg gga cgg tct caa caa aat tca ggt cca ttc cag ttc tct gat tat     1135
 Trp Gly Arg Ser Gln Gln Asn Ser Gly Pro Phe Gln Phe Ser Asp Tyr
                 310                 315                 320

 aga atc cag agg ctc aaa agg gaa agg ctg gta gca agc aat aat aaa     1183
 Arg Ile Gln Arg Leu Lys Arg Glu Arg Leu Val Ala Ser Asn Asn Lys
             325                 330                 335

 att cga gac cca gtc tca gag cca tcg gtg gag aaa ttc tcc ccg cct     1231
 Ile Arg Asp Pro Val Ser Glu Pro Ser Val Glu Lys Phe Ser Pro Pro
         340                 345                 350

 tca gaa aca cca gtc ggt gct ttg cag gga tcc gcc aga aat tcc agc     1279
 Ser Glu Thr Pro Val Gly Ala Leu Gln Gly Ser Ala Arg Asn Ser Ser
     355                 360                 365

 ctg tcc atg gca cca gac tcc tca ggt tcc agc ggc tcc att gaa gag     1327
 Leu Ser Met Ala Pro Asp Ser Ser Gly Ser Ser Gly Ser Ile Glu Glu
 370                 375                 380                 385

 cca cag ctg ggt gag tgc agc cac tgt ggg cgc aaa ttc ctc tcg ttc     1375
 Pro Gln Leu Gly Glu Cys Ser His Cys Gly Arg Lys Phe Leu Ser Phe
                 390                 395                 400

 agg ctg gag aga cac tcc aac atc tgc agc agg atg cgg ggt tcc aag     1423
 Arg Leu Glu Arg His Ser Asn Ile Cys Ser Arg Met Arg Gly Ser Lys
             405                 410                 415

 agg aaa gtg ttt gac tcc tcc agg gcc cgg gct aag ggc aca gaa cta     1471
 Arg Lys Val Phe Asp Ser Ser Arg Ala Arg Ala Lys Gly Thr Glu Leu
         420                 425                 430

 gag cag tac ttg aac tgg aag ggg cca gct tca gcc aag gct gaa cct     1519
 Glu Gln Tyr Leu Asn Trp Lys Gly Pro Ala Ser Ala Lys Ala Glu Pro
     435                 440                 445

 cct cag aag agc aac tgg aga tag aagcatgaat cttttatcca tacgttccgc    1573
 Pro Gln Lys Ser Asn Trp Arg 
 450                 455

 caggctcgag aggtccagca ggtaactgcc aaaggtggaa actgttcaca cttgcctccc   1633

 atcctgcctg cagaaaaccc agactgcatt cagtgtcctc agtgtagcca ccactttgct   1693

 cccaaggtgg ctgagcaaca cattcccaag tgtaagacca tcaagaactg tcatccacct   1753

 ctaaggaagc attatagttg agcagacaac aatggaaact tttggatagt tcagaaagct   1813

 ctgcttctct tcagcagtaa atgggagtag aatttgatgc aaagcagaaa gaaatcaaac   1873

 agctcccaga tctgcctgca gagctaaaat ctgtgaggag agagccactg ctaagcagca   1933

 ggaggcagaa ggaagcccca gcttcccact aaattacaac cttgggctgg tatgctttat   1993

 gttattgccc tcagaattga tgggtgaaga cactgaagag tcatgagcag gctccattaa   2053

 agctcttttc ttgcaaaaaa aaaaaa                                        2079




      <210> 207
      <211> 2739
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1017)..(1199)

      <400> 207
 cagggttgtt gcttttcttt gtggaaagtg aaaccatcca aatgtaaatg ggttttggta     60

 aaaatttaaa tcattagtat tccccctcac ctccccctat cactttaaaa cttattttgg    120

 attaagaaaa aatctgggca tggaagaaga aagaagcatg tcttcatcgt attaccaaag    180

 ttcatgctta tctccggaat gtgagtggag gtgaagctgc ctccaagaag aagcataaaa    240

 gtggaatgga gccaggaaat ccgatggttc tagaaatagt ctgatattta aacatgtgat    300

 acctggcagt ctcgtttaac aggtacaagg aaaacgtgcc tagattccca ggaacatgca    360

 aaatcctttc tttcttatct ctttagctct ggactgtgat tggcaaggtc cttcttccag    420

 cattcagccc agctaagccc ccaggtgccc catcccaacc ctgttcctcc tgtccacctg    480

 ccatccccta tgcaaacagt aagaataacc ccattcaaaa agcacatcat cgttttccat    540

 ttgcattaac atgtgtctca gtcccatgtt gccgttgctt gggattgtct gtcagtttta    600

 ttttcaaagg catccatggc ttgcacaatc ctgttccagt catgactgaa catttgctcc    660

 ttcttcatgt gccgttcgga aatgttgttg tgatacctgt tacacagtgc atggtgaaaa    720

 acaaataaaa caaaacaaag agtatctgta tatagtagag tatagtacat actgttctcc    780

 catttggcaa tgttgattgg acattgaaga cataagtgag ttttcttttc acctgagttg    840

 ttacttttgt gctgttattg agtttgatta attactaggg ataaaaggag aaaatggatt    900

 attgttcacg gttctgcaca ttcatttcta agaagcaata actgtcatgt ggggagaagt    960

 taaagctatt gagaggatag caggcaaact acaaagatct tcatggaaaa ttagcc       1016                                                                 
 atg tgg aac aca tca gag gcc tct aaa aat cac cca tta att cag gaa     1064
 Met Trp Asn Thr Ser Glu Ala Ser Lys Asn His Pro Leu Ile Gln Glu
   1               5                  10                  15

 ggc caa gga gaa agg cct tat aga gac gtt gat atg ttg gat gtg cct     1112
 Gly Gln Gly Glu Arg Pro Tyr Arg Asp Val Asp Met Leu Asp Val Pro
              20                  25                  30

 agg ctt tca gag cca ccc ttt cca caa cac ccc tcc ctg caa agt att     1160
 Arg Leu Ser Glu Pro Pro Phe Pro Gln His Pro Ser Leu Gln Ser Ile
          35                  40                  45

 tat ttc aca tct gca ctg tct ggc aca gat ggt aga tag tgctggtttg      1209
 Tyr Phe Thr Ser Ala Leu Ser Gly Thr Asp Gly Arg 
      50                  55                  60

 ttcattttat ttttttactt aaaaggctat tttgagccct gtttctttca ctgtccagtc   1269

 tagtcctctt tgattatatc agtagttgct gagtaagaaa gaagccaggg tgaccaacgg   1329

 gcctttaaaa gtgtgtctcc tctacttatg ctgaaagaga aggcaattaa ataagactag   1389

 tacctcccag gaggattgga ctgggatatt tttaaccctt taaaaagaat agctgtttct   1449

 atgttaaaat accaaagaac atggataaac ccaacattcc aaagtagtga gtccactaat   1509

 gagaaaaata atagaatgac tttggtcacc tctcggagac ttctgtgtct ataaggaatc   1569

 ccaggctgga gacattccta gccctctgta ttgattcaaa aatacttaat aaattaaagc   1629

 tgttgagact tattttttct tctgtcactc agtaaccatg atccttcctc atttaataaa   1689

 catttggtga ctgaatgagt aattaaatgc tggttaccca cttaatgtgc caggtagtat   1749

 gatactttct ggggactaag ccatgaacaa aacagtctag atccctgccc tcagaagggt   1809

 tacagtttat gtgattacta ttttcatgag taaaagtgaa gaaagccata tggaaagatt   1869

 tttatcttgc aagaaaaaac aattatgaaa ctcttttaac ataaacacac tgaaactgta   1929

 tcaaagcaat tgtccaaatt gtatttatac ccaagaattt ctttaactaa gagagcataa   1989

 ggcatatgtt tggaaaacca ccctctttat ctttgaccgg cttgcagata aatatatctc   2049

 tccattttaa accaagaagg gcaatcatgt tggtgatcca gatcactgag aaagcccagt   2109

 gtatcccatc ttttatcttt gttggcaatg gaacttttct atggcccaca ctttacaatt   2169

 ctttgtcatt ctaacccatc cttcccatcc ttattttttt tttttttgag aattgctaaa   2229

 tggaaagcta gcctagaagc accaagtaaa tatattcaag gaatataagt tgtttaaaca   2289

 ttagaaaaat ttttgcactc attttttagc tgtattagga atgtcaataa tcctgtagca   2349

 aattttcaca gagaacttta agaaattctt gcattggtcg atttcaattt gaaagctttt   2409

 tggtttgttt gctttttaaa ttttcatgtt ctaggaaact atgattctgg ttgttcagga   2469

 ttgttattat tatagttgtg taaaattatt ttattttgtg tgtattgtgc acagcttggg   2529

 ggggggcggg aaatgcacta attgtgctct tccttataaa tggtacatat tactgacaca   2589

 gacaaataaa gtttctaatt gtttctgatt taatcactag tgatacagca tattctgtat   2649

 gaaatgtttt ctcctttctc attgtcatct acttcatttt ttgttttcat gttttgaaga   2709

 aataaaaacc aaaatggtaa aaaaaaaaaa                                    2739




      <210> 208
      <211> 1962
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (178)..(1911)

      <400> 208
 aaaaatattt gcagctcaga ttgggtcagc ttggtcacat tggtcagatt gggtcaaagt     60

 gggtcagctc agattgtgca gtccgacccc aggccatggg gaagtgacac agagaccagt    120

 aataatcttg atgcctgttg ccaagccctt tcccaggaga gtagcaaata cttatat       177                                                                 
 atg gaa tac cat agt cca gat gac aat agg atg aat aga aat cgc ctt      225
 Met Glu Tyr His Ser Pro Asp Asp Asn Arg Met Asn Arg Asn Arg Leu
   1               5                  10                  15

 tta cat att aac ctg ggt atc cat tct cct agt agc tat cac cca gga      273
 Leu His Ile Asn Leu Gly Ile His Ser Pro Ser Ser Tyr His Pro Gly
              20                  25                  30

 gat gga gcc caa ctt aat ggt ggt cga aca ctg gta cat agc tca agt      321
 Asp Gly Ala Gln Leu Asn Gly Gly Arg Thr Leu Val His Ser Ser Ser
          35                  40                  45

 gat gga cat att gat cct cag cat gca gca ggt aaa cag ctg ata tgt      369
 Asp Gly His Ile Asp Pro Gln His Ala Ala Gly Lys Gln Leu Ile Cys
      50                  55                  60

 tta gtt caa gaa cca cac tca gct cca gct gtt gtt gct gct act ccc      417
 Leu Val Gln Glu Pro His Ser Ala Pro Ala Val Val Ala Ala Thr Pro
  65                  70                  75                  80

 aac tac aat cca ttt ttt atg aac gaa cag aac aga agt gca gct act      465
 Asn Tyr Asn Pro Phe Phe Met Asn Glu Gln Asn Arg Ser Ala Ala Thr
                  85                  90                  95

 cct cct tca caa cca cct caa cag cca tct tcc atg caa aca gga atg      513
 Pro Pro Ser Gln Pro Pro Gln Gln Pro Ser Ser Met Gln Thr Gly Met
             100                 105                 110

 aat ccg tct gct atg caa ggg cct tca cca cca ccg cca cct cct tca      561
 Asn Pro Ser Ala Met Gln Gly Pro Ser Pro Pro Pro Pro Pro Pro Ser
         115                 120                 125

 tac atg cac ata cct cgg tat agt aca aat cca att act gtt aca gta      609
 Tyr Met His Ile Pro Arg Tyr Ser Thr Asn Pro Ile Thr Val Thr Val
     130                 135                 140

 tcc cag aac ctc cct tct gga cag act gta cca aga gct tta caa att      657
 Ser Gln Asn Leu Pro Ser Gly Gln Thr Val Pro Arg Ala Leu Gln Ile
 145                 150                 155                 160

 ctt cca caa att cca agc aat ctc tat ggg tct cct ggt tct att tat      705
 Leu Pro Gln Ile Pro Ser Asn Leu Tyr Gly Ser Pro Gly Ser Ile Tyr
                 165                 170                 175

 att aga cag aca tct cag agt tca tca gga aga caa act cct cag agt      753
 Ile Arg Gln Thr Ser Gln Ser Ser Ser Gly Arg Gln Thr Pro Gln Ser
             180                 185                 190

 acg ccg tgg cag tcc tca cca cag ggc cca gtg cct cac tat agc cag      801
 Thr Pro Trp Gln Ser Ser Pro Gln Gly Pro Val Pro His Tyr Ser Gln
         195                 200                 205

 cgt cct tta cct gtt tat cca cac caa cag aac tat cag cct tct cag      849
 Arg Pro Leu Pro Val Tyr Pro His Gln Gln Asn Tyr Gln Pro Ser Gln
     210                 215                 220

 tat tct ccc aaa cag cag cag atc cct cag tct gct tac cat tca cca      897
 Tyr Ser Pro Lys Gln Gln Gln Ile Pro Gln Ser Ala Tyr His Ser Pro
 225                 230                 235                 240

 cct cct tct caa tgt cct tca ccc ttc agc tct cca cag cat caa gtg      945
 Pro Pro Ser Gln Cys Pro Ser Pro Phe Ser Ser Pro Gln His Gln Val
                 245                 250                 255

 caa cct tcc cag ttg ggc cac atc ttt atg cca cct agt cct tca act      993
 Gln Pro Ser Gln Leu Gly His Ile Phe Met Pro Pro Ser Pro Ser Thr
             260                 265                 270

 act cca ccc cat cca tat caa caa gga cct cct agc tat cag aaa cag     1041
 Thr Pro Pro His Pro Tyr Gln Gln Gly Pro Pro Ser Tyr Gln Lys Gln
         275                 280                 285

 gga agc cat tca gta gcc tat ctt cca tac aca gca tct agt tta tcc     1089
 Gly Ser His Ser Val Ala Tyr Leu Pro Tyr Thr Ala Ser Ser Leu Ser
     290                 295                 300

 aaa ggt tcc atg aag aag ata gaa att aca gtt gaa cct tct caa aga     1137
 Lys Gly Ser Met Lys Lys Ile Glu Ile Thr Val Glu Pro Ser Gln Arg
 305                 310                 315                 320

 cct ggg aca gca att aat agg agt cct tca ccc atc agt aat caa cta     1185
 Pro Gly Thr Ala Ile Asn Arg Ser Pro Ser Pro Ile Ser Asn Gln Leu
                 325                 330                 335

 tct cca cgg aat caa cac tca ctg tac aca gcc acc acg cca cct tca     1233
 Ser Pro Arg Asn Gln His Ser Leu Tyr Thr Ala Thr Thr Pro Pro Ser
             340                 345                 350

 agt tct cct tca aga ggg ata tct agt caa cca aaa cct cca ttt agt     1281
 Ser Ser Pro Ser Arg Gly Ile Ser Ser Gln Pro Lys Pro Pro Phe Ser
         355                 360                 365

 gtt aat cct gtg tat att aca tat aca cag cca act gga cct tct tgt     1329
 Val Asn Pro Val Tyr Ile Thr Tyr Thr Gln Pro Thr Gly Pro Ser Cys
     370                 375                 380

 act cca tca cca tct cct cga gtg ata cca aac cca act aca gtt ttt     1377
 Thr Pro Ser Pro Ser Pro Arg Val Ile Pro Asn Pro Thr Thr Val Phe
 385                 390                 395                 400

 aaa att acc gta ggc cga gca acg act gaa aat ctt tta aat tta gtg     1425
 Lys Ile Thr Val Gly Arg Ala Thr Thr Glu Asn Leu Leu Asn Leu Val
                 405                 410                 415

 gac caa gaa gag cgc tct gca gca cca gaa cct att cag ccc att tca     1473
 Asp Gln Glu Glu Arg Ser Ala Ala Pro Glu Pro Ile Gln Pro Ile Ser
             420                 425                 430

 gtg ata cca ggc tct ggg gga gaa aag gga agc cat aaa tat cag aga     1521
 Val Ile Pro Gly Ser Gly Gly Glu Lys Gly Ser His Lys Tyr Gln Arg
         435                 440                 445

 agt tct agt tct gga tca gat gac tat gcc tac aca caa gcc ttg ctg     1569
 Ser Ser Ser Ser Gly Ser Asp Asp Tyr Ala Tyr Thr Gln Ala Leu Leu
     450                 455                 460

 tta cat caa cga gca agg atg gag agg tta gca aag caa ctg aaa ctt     1617
 Leu His Gln Arg Ala Arg Met Glu Arg Leu Ala Lys Gln Leu Lys Leu
 465                 470                 475                 480

 gag aaa gag gag cta gag cgg ttg aag tct gaa gtt aat ggt atg gag     1665
 Glu Lys Glu Glu Leu Glu Arg Leu Lys Ser Glu Val Asn Gly Met Glu
                 485                 490                 495

 cat gac ctg atg cag aga cgg ctc aga aga gtc agc tgc acc act gcg     1713
 His Asp Leu Met Gln Arg Arg Leu Arg Arg Val Ser Cys Thr Thr Ala
             500                 505                 510

 atc cct acg cct gag gaa atg aca aga ttg aga agc atg aac aga caa     1761
 Ile Pro Thr Pro Glu Glu Met Thr Arg Leu Arg Ser Met Asn Arg Gln
         515                 520                 525

 ctc cag ata aat gtt gac tgt aca ctg aaa gaa gtt gac ctc ctt caa     1809
 Leu Gln Ile Asn Val Asp Cys Thr Leu Lys Glu Val Asp Leu Leu Gln
     530                 535                 540

 tct aga gaa gta tac tac agc aga agc tct ctt aaa ctt tca ttt acc     1857
 Ser Arg Glu Val Tyr Tyr Ser Arg Ser Ser Leu Lys Leu Ser Phe Thr
 545                 550                 555                 560

 caa ctc acc aga tta gag atg gtc ttc att ttc tgt gga aaa tat act     1905
 Gln Leu Thr Arg Leu Glu Met Val Phe Ile Phe Cys Gly Lys Tyr Thr
                 565                 570                 575

 gac tga tgtccacagc tgctgcatac ttttgactag taggctgcat tctggaaact      1961
 Asp 


 t                                                                   1962




      <210> 209
      <211> 1257
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (320)..(655)

      <400> 209
 gccagctcca ctctgtccct cctcgccggg tctgtgcgtc tttgcgtctg tctgtctgac     60

 tgatggtcct cacacgcggt tccctgtgac tgggcgcgac cccggcaagc gcggcttgga    120

 gggcggacgg ggcgcggcga tacagctgcc cgctcgcatc tttggccctg cgctcagctc    180

 ctcacccggc gtgggaagtt aaagtaaaac cgaaagggaa gaaggcgcgg tggcaggagc    240

 tgacagagtg atgggaaacg cgtgagccag gccgagagtt tcaggtttct tgctgtatgg    300

 atcactgatt gaataatag atg gct tta cct cgt ctc aca gga gcc ttg cgt     352
                      Met Ala Leu Pro Arg Leu Thr Gly Ala Leu Arg
                        1               5                  10

 tcc ttt tca aat gtc acc aag caa gat aat tat aat gaa gaa gtg gct      400
 Ser Phe Ser Asn Val Thr Lys Gln Asp Asn Tyr Asn Glu Glu Val Ala
              15                  20                  25

 gac tta aag ata aag cga tct aaa ctt cat gaa caa gtt tta gat ttg      448
 Asp Leu Lys Ile Lys Arg Ser Lys Leu His Glu Gln Val Leu Asp Leu
          30                  35                  40

 ggc ctg aca tgg aag aag ata ata aaa ttt ttg aat gaa aaa ctg gag      496
 Gly Leu Thr Trp Lys Lys Ile Ile Lys Phe Leu Asn Glu Lys Leu Glu
      45                  50                  55

 aag agt aaa atg caa agt ata aat gaa gac tta aaa gat ata tta cat      544
 Lys Ser Lys Met Gln Ser Ile Asn Glu Asp Leu Lys Asp Ile Leu His
  60                  65                  70                  75

 gct gca aag cag ata gaa gtg aat tgt cca ttc cag aag agg agg ctg      592
 Ala Ala Lys Gln Ile Glu Val Asn Cys Pro Phe Gln Lys Arg Arg Leu
                  80                  85                  90

 gat gga aaa gag gag gat gag aag atg agc aga gct tct gac aga ttc      640
 Asp Gly Lys Glu Glu Asp Glu Lys Met Ser Arg Ala Ser Asp Arg Phe
              95                 100                 105

 aga gga cta aga tga caaaaatgac taaaatggac aaaagaagaa atagaaaatc      695
 Arg Gly Leu Arg 
         110

 tgaatatttg actattaaag gaatttaatc tgtaattaaa aaccttaagt acaaagaaat    755

 ctatatgcta tgatggcttt aatggagaat gtcataatgt catttaaaaa ggtatgagag    815

 tactattgta gattaaaaga ggttaaaggc atataataat caaaatgtaa tgtatgatcc    875

 ttgattgact cttgaatcag aaaaaaatta cgtatttttg gggccgttgg agaaatctga    935

 atatgggctg gacatcatta ggtaatatta gatctcaggt gtgataatgt tgtggctatg    995

 taagaggata tcctaaatct caggagaagc atactgcagt atatatagtg gtatctcatg   1055

 aagattaaaa tgtactgtca aatgtgtcag caaaagaaat acacatgatg tgtgtgtgtg   1115

 atcaagtgtt tataatggag tgggattaat aaatatgaga agatagggtg atttgttgta   1175

 aagtaataaa ggtttaaaaa ttacatgatt cagtagagaa aaagcatttt atgaatatct   1235

 aacattactt atgataaaaa at                                            1257




      <210> 210
      <211> 2812
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (177)..(1976)

      <400> 210
 ctcccaggga cactcttgat ggcaggaatg aaaatcttca ggaaagtgag attctaagtc     60

 aacctaagag tcttagcctg gaagcaacct ctcctctttc tgcagaaaaa cattcttgca    120

 cagtgcctga aggccttctg tttcctgcag aatattatgt tagaacaaca cgaagc        176                                                                 
 atg tcc aat tgc cag agg aaa gta gcc gtg gag gct gtc att cag agt      224
 Met Ser Asn Cys Gln Arg Lys Val Ala Val Glu Ala Val Ile Gln Ser
   1               5                  10                  15

 cat ttg gat gtc aag aaa aaa ggg ttt aaa aat aaa aat aag gat gca      272
 His Leu Asp Val Lys Lys Lys Gly Phe Lys Asn Lys Asn Lys Asp Ala
              20                  25                  30

 agt aaa aat tta aac ctt tcc aat gag gaa act gac caa agt gaa att      320
 Ser Lys Asn Leu Asn Leu Ser Asn Glu Glu Thr Asp Gln Ser Glu Ile
          35                  40                  45

 agg atg tct ggc aca tgc aca gga caa cca agt tca aga acc tct cag      368
 Arg Met Ser Gly Thr Cys Thr Gly Gln Pro Ser Ser Arg Thr Ser Gln
      50                  55                  60

 aaa ctt ctc tca tta act aaa gtc agc tct ccc gct ggg ccc act gaa      416
 Lys Leu Leu Ser Leu Thr Lys Val Ser Ser Pro Ala Gly Pro Thr Glu
  65                  70                  75                  80

 gat aat gac ttg tct agg aag gca gtt gcc caa gca cct ggt aga aga      464
 Asp Asn Asp Leu Ser Arg Lys Ala Val Ala Gln Ala Pro Gly Arg Arg
                  85                  90                  95

 tac aca gga aaa aga aaa tca gcc tgc acc cca gca tca gat cat tgt      512
 Tyr Thr Gly Lys Arg Lys Ser Ala Cys Thr Pro Ala Ser Asp His Cys
             100                 105                 110

 gaa cca ctt ttg cca act tct agc ctg tcg att gtt aac agg tcc aag      560
 Glu Pro Leu Leu Pro Thr Ser Ser Leu Ser Ile Val Asn Arg Ser Lys
         115                 120                 125

 gaa gaa gtc acc tca cac aaa tat cag cac gaa aaa tta ttt att caa      608
 Glu Glu Val Thr Ser His Lys Tyr Gln His Glu Lys Leu Phe Ile Gln
     130                 135                 140

 gtg aaa ggg aag aaa agt cgt cat caa aaa gag gat tcc ctt tct tgg      656
 Val Lys Gly Lys Lys Ser Arg His Gln Lys Glu Asp Ser Leu Ser Trp
 145                 150                 155                 160

 agt aat agt gct tat tta tcc ttg gat gat gat gct ttc acg gct cca      704
 Ser Asn Ser Ala Tyr Leu Ser Leu Asp Asp Asp Ala Phe Thr Ala Pro
                 165                 170                 175

 ttt cat agg gat gga atg ctg agt tta aag caa cta ctg tct ttt ctc      752
 Phe His Arg Asp Gly Met Leu Ser Leu Lys Gln Leu Leu Ser Phe Leu
             180                 185                 190

 agt atc aca gac ttt cag tta cct gat gaa gac ttt gga cct ctt aag      800
 Ser Ile Thr Asp Phe Gln Leu Pro Asp Glu Asp Phe Gly Pro Leu Lys
         195                 200                 205

 ctt gaa aaa gtg aag tcc tgc tca gaa aaa cca gtg gag ccc ttt gag      848
 Leu Glu Lys Val Lys Ser Cys Ser Glu Lys Pro Val Glu Pro Phe Glu
     210                 215                 220

 tca aaa atg ttt gga gag aga cat ctt aaa gag gga agc tgt att ttt      896
 Ser Lys Met Phe Gly Glu Arg His Leu Lys Glu Gly Ser Cys Ile Phe
 225                 230                 235                 240

 cca gag gaa ctg agt cct aaa cgc atg gat aca gaa atg gag gac tta      944
 Pro Glu Glu Leu Ser Pro Lys Arg Met Asp Thr Glu Met Glu Asp Leu
                 245                 250                 255

 gaa gag gac ctt att gtt cta cca gga aaa tca cat ccc aaa agg cca      992
 Glu Glu Asp Leu Ile Val Leu Pro Gly Lys Ser His Pro Lys Arg Pro
             260                 265                 270

 aac tcg caa agc cag cat aca aag acg ggc ctt tct tca tcc ata tta     1040
 Asn Ser Gln Ser Gln His Thr Lys Thr Gly Leu Ser Ser Ser Ile Leu
         275                 280                 285

 ctt tat act cct tta aat acg gtt gcg cct gat gat aat gac agg cct     1088
 Leu Tyr Thr Pro Leu Asn Thr Val Ala Pro Asp Asp Asn Asp Arg Pro
     290                 295                 300

 acc aca gac atg tgt tca cct gct ttc ccc atc tta ggt act act cca     1136
 Thr Thr Asp Met Cys Ser Pro Ala Phe Pro Ile Leu Gly Thr Thr Pro
 305                 310                 315                 320

 gcc ttt ggc cct caa ggc tcc tat gaa aaa gca tct aca gaa gtt gct     1184
 Ala Phe Gly Pro Gln Gly Ser Tyr Glu Lys Ala Ser Thr Glu Val Ala
                 325                 330                 335

 gga cga act tgc tgc aca ccc caa ctt gct cat ttg aaa gac tca gtc     1232
 Gly Arg Thr Cys Cys Thr Pro Gln Leu Ala His Leu Lys Asp Ser Val
             340                 345                 350

 tgt ctt gcc agt gat act aaa caa ttc gac agt tca ggc agc cca gca     1280
 Cys Leu Ala Ser Asp Thr Lys Gln Phe Asp Ser Ser Gly Ser Pro Ala
         355                 360                 365

 aaa cca cat acc acc ctg caa gtg tca ggc agg caa gga caa cct acc     1328
 Lys Pro His Thr Thr Leu Gln Val Ser Gly Arg Gln Gly Gln Pro Thr
     370                 375                 380

 tgt gac tgt gac tct gtc ccg cca gga aca cct cca ccc att gag tca     1376
 Cys Asp Cys Asp Ser Val Pro Pro Gly Thr Pro Pro Pro Ile Glu Ser
 385                 390                 395                 400

 ttc act ttt aaa gaa aat cag ctc tgt aga aac aca tgc cag gag ctg     1424
 Phe Thr Phe Lys Glu Asn Gln Leu Cys Arg Asn Thr Cys Gln Glu Leu
                 405                 410                 415

 cat aaa cat tcc gtc gaa cag act gaa aca gca gag ctt cct gct tct     1472
 His Lys His Ser Val Glu Gln Thr Glu Thr Ala Glu Leu Pro Ala Ser
             420                 425                 430

 gat agc ata aac cca ggc aac cta caa ttg gtt tca gag tta aag aat     1520
 Asp Ser Ile Asn Pro Gly Asn Leu Gln Leu Val Ser Glu Leu Lys Asn
         435                 440                 445

 cct tca ggt tcc tgt tcc gta gat gtg agt gcc atg ttt tgg gaa aga     1568
 Pro Ser Gly Ser Cys Ser Val Asp Val Ser Ala Met Phe Trp Glu Arg
     450                 455                 460

 gcc ggt tgt aaa gag cca tgt atc ata act gct tgc gaa gat gta gtt     1616
 Ala Gly Cys Lys Glu Pro Cys Ile Ile Thr Ala Cys Glu Asp Val Val
 465                 470                 475                 480

 tct ctt tgg aaa gct ctg gat gct tgg cag tgg gaa aaa ctt tat acc     1664
 Ser Leu Trp Lys Ala Leu Asp Ala Trp Gln Trp Glu Lys Leu Tyr Thr
                 485                 490                 495

 tgg cac ttc gca gag gtt cca gta tta cag ata gtt cca gtg cct gat     1712
 Trp His Phe Ala Glu Val Pro Val Leu Gln Ile Val Pro Val Pro Asp
             500                 505                 510

 gtg tat aat ctc gtg tgt gta gct ttg gga aat ttg gaa atc aga gag     1760
 Val Tyr Asn Leu Val Cys Val Ala Leu Gly Asn Leu Glu Ile Arg Glu
         515                 520                 525

 atc agg gca ttg ttt tgt tcc tct gat gat gaa agt gaa aag caa gta     1808
 Ile Arg Ala Leu Phe Cys Ser Ser Asp Asp Glu Ser Glu Lys Gln Val
     530                 535                 540

 cta ctg aag tct gga aat ata aaa gct gtg ctt ggc ctg aca aag agg     1856
 Leu Leu Lys Ser Gly Asn Ile Lys Ala Val Leu Gly Leu Thr Lys Arg
 545                 550                 555                 560

 agg cta gtt agt agc agt ggg acc ctt tct gat caa caa gta gaa gtc     1904
 Arg Leu Val Ser Ser Ser Gly Thr Leu Ser Asp Gln Gln Val Glu Val
                 565                 570                 575

 atg acg ttt gca gaa gat gga gga ggc aaa gaa aac caa ttt ttg atg     1952
 Met Thr Phe Ala Glu Asp Gly Gly Gly Lys Glu Asn Gln Phe Leu Met
             580                 585                 590

 ccc cct gag gag act aat aac taa acatatgctt gaggtcccaa gggattgcaa    2006
 Pro Pro Glu Glu Thr Asn Asn 
         595

 aaaaggttct ggtagggtat acctattatg agcaccctgg tcatttggaa tttaaaaact   2066

 ggtcaactcc tgaaaaagat gcacattgat gattcttacc aagcttcagt ctgtcacaaa   2126

 gcctattctg aaatggggct tctctttatt gtcctgagtc atccctgtgc caaagagagt   2186

 gagtcgttgc gaagccctgt gtttcagctc attgtgatta accctaagac gactctcagc   2246

 gtgggtgtga tgctgtactg tcttcctcca gggcaggctg gcaggttcct ggaaggtgac   2306

 gtgaaagatc actgtgcagc agcaatcttg acttctggaa caattgccat ttgggactta   2366

 cttctcggtc agtgtactgc cctcctccca cctgtctctg accaacattg gtcttttgtg   2426

 aaatggtcgg gtacagactc tcatttgctg gctggacaaa aagatggaaa tatatttgta   2486

 taccactatt cataagttag ggtaaagtga aaacacaatt ttctggatat attgggcctc   2546

 ttagtatttt ttggagtttt aaatataaag gagaatatct gaatgacact taaaatgatt   2606

 gcttgtttat gtccagacag acttattttt tattctaatg atggtagcac cactgatctt   2666

 ggatgtacat ttatgtatac tttgagaaaa agggttttag gttgattttt gtaatttccc   2726

 acatttgtac atgtgctttt aaaggtgtac ataaagcttc aaatggcaat aaatatttat   2786

 ttttatacaa aaaaaaaaaa aaaaaa                                        2812




      <210> 211
      <211> 706
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (286)..(522)

      <400> 211
 tcctcagcag cattcagcgt tcctggtgga gatctggcac tgaggatctc tcaggaagtg     60

 aatgggagtg tccgcccctc tcaggactcc cacgccgtcc actctccgag aacaggtttc    120

 cgggcatcgg ggcatctggc agaagatgga agctctggcc tcactgctgg ctggcctggc    180

 ctggactcct gagctccgtc tcctctcacc gggccccggg gtcttgaccc tgagtgggtg    240

 acaggcccct tcttttccag gctgggaggg tgtgaccaga gtgtc    atg gac ctg     294
                                                      Met Asp Leu
                                                        1

 ata aag cga aac tcc gga tgg gtg ttt gag aat ccc tca ata ggc gtg      342
 Ile Lys Arg Asn Ser Gly Trp Val Phe Glu Asn Pro Ser Ile Gly Val
       5                  10                  15

 ctg gag ctc tgg gtg ctg gcc acc aac ttc aga gac tat gcc atc atc      390
 Leu Glu Leu Trp Val Leu Ala Thr Asn Phe Arg Asp Tyr Ala Ile Ile
  20                  25                  30                  35

 ttc act cag ctg gag ttc ggg gac gag ccc ttc aac acc gtg gag ctg      438
 Phe Thr Gln Leu Glu Phe Gly Asp Glu Pro Phe Asn Thr Val Glu Leu
                  40                  45                  50

 tac agt ctg acg gag aca gcc agc cag gag gcc atg ggg ctc ttc acc      486
 Tyr Ser Leu Thr Glu Thr Ala Ser Gln Glu Ala Met Gly Leu Phe Thr
              55                  60                  65

 aag tgg agc agg agc ctg ggc ttc ctg tca cag tag cagg cccagctgca      536
 Lys Trp Ser Arg Ser Leu Gly Phe Leu Ser Gln 
          70                  75

 gaaggacctc acctgtgctc acaagatcct tctgtgagtg ctgcgtcccc agtagggatg    596

 gcgcccacag ggtcctgtga cctcggccag tgtccaccca cctcgctcag cggctcccgg    656

 ggcccagcac cagctcagaa taaagcgatt ccacagcaaa aaaaaaaaaa               706




      <210> 212
      <211> 766
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (249)..(728)

      <400> 212
 aaggcgaaga agaaagaaag gttaagcagt gaagaaaggg acggagatac tgggacaggg     60

 agaaaaaagt tgtggagagt agcttttaag gagtcatttg gtggccatgg atccaacgtg    120

 ctcttctgag tgcatttata acctcatacc cagtgacttg aaggagcctc cccagcctcc    180

 tagaaaaaaa ctttgatcgg aacgtgccca aaaagcctgc tgtgccattg aagactgatc    240

 atcctgtc atg gga ata cag agt gga aaa aat ttt ata aat aca aat gca     290
          Met Gly Ile Gln Ser Gly Lys Asn Phe Ile Asn Thr Asn Ala
            1               5                  10

 gct gat atc atc atg gga gtg gct aaa aag cct aaa cca att tat gtt      338
 Ala Asp Ile Ile Met Gly Val Ala Lys Lys Pro Lys Pro Ile Tyr Val
  15                  20                  25                  30

 gat aaa aga act gga gac aag cat gat ctt gag cct tca gga cta gtt      386
 Asp Lys Arg Thr Gly Asp Lys His Asp Leu Glu Pro Ser Gly Leu Val
                  35                  40                  45

 cca aag tac atc aat aaa aag gat tat ggt gtc aca cct gaa tac ata      434
 Pro Lys Tyr Ile Asn Lys Lys Asp Tyr Gly Val Thr Pro Glu Tyr Ile
              50                  55                  60

 tgt aag cga aac gag gaa ata aag aaa gcc caa gaa gac tat gat cgt      482
 Cys Lys Arg Asn Glu Glu Ile Lys Lys Ala Gln Glu Asp Tyr Asp Arg
          65                  70                  75

 tat atc cag gaa aac ctt aag aaa gca gct atg aaa agg ctc tcc gat      530
 Tyr Ile Gln Glu Asn Leu Lys Lys Ala Ala Met Lys Arg Leu Ser Asp
      80                  85                  90

 gaa gaa agg gag gca gtt ttg cag ggg ctg aaa aag aac tgg gaa gag      578
 Glu Glu Arg Glu Ala Val Leu Gln Gly Leu Lys Lys Asn Trp Glu Glu
  95                 100                 105                 110

 gtg cat aaa gaa ttc cag tcc ctc tcg gtc ttt ata gat tct ata cca      626
 Val His Lys Glu Phe Gln Ser Leu Ser Val Phe Ile Asp Ser Ile Pro
                 115                 120                 125

 aag aag atc cgc aag cag agg ctg gaa gaa gaa atg aaa caa cta gaa      674
 Lys Lys Ile Arg Lys Gln Arg Leu Glu Glu Glu Met Lys Gln Leu Glu
             130                 135                 140

 cac gac att ggc ata att gaa aag cac aag att att tat att gcc aat      722
 His Asp Ile Gly Ile Ile Glu Lys His Lys Ile Ile Tyr Ile Ala Asn
         145                 150                 155

 aag taa gaatggatct ttaaagtata acaatttcaa tgtagggg                    766
 Lys 






      <210> 213
      <211> 1272
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (394)..(1272)

      <400> 213
 atgaaaaagg cgcttactgt ggccacttcc tcctttccca cctctgccct agaaggagcc     60

 cttgggaatg cacagccctc cattgtttgt ctggtgctgt ttctgccaaa actcccagga    120

 gaagcccgga gccctgaccc aagggccttt ggaaaggaca aatccccgag ggggaggctg    180

 ctgaacccga gctggtgtga gcttctcttg ccgtaagtcc acgggtggcc aggcccacgt    240

 gttagtctgg ttaagagctc tgctcagaag tagccgctgc agctgaaggt tttcaggcgg    300

 gctgaaggct gggccgcttc ttcattcatt tcagaaactt gaacagtggg ccttctacac    360

 acgctgtctt tgtcagcctc aggcagttcc tcc atg gat gag aca cag ggg cct     414
                                      Met Asp Glu Thr Gln Gly Pro
                                        1               5

 ctg gcc atg act gtc cat ctt ctt gcc aac tct ggg cac ggc tcc ctt      462
 Leu Ala Met Thr Val His Leu Leu Ala Asn Ser Gly His Gly Ser Leu
          10                  15                  20

 ctg cag agg act ctg gac cag ctc ctg gat tgc att tgc cca gag gtc      510
 Leu Gln Arg Thr Leu Asp Gln Leu Leu Asp Cys Ile Cys Pro Glu Val
      25                  30                  35

 cgg ctc ttt cag gtg tct gaa cgg gcc agt cct gtg aaa tac tgt gaa      558
 Arg Leu Phe Gln Val Ser Glu Arg Ala Ser Pro Val Lys Tyr Cys Glu
  40                  45                  50                  55

 aag tcc cat tcc aag cgg tcc cgg ttt cca ggg atg tcc gtg ttg ctc      606
 Lys Ser His Ser Lys Arg Ser Arg Phe Pro Gly Met Ser Val Leu Leu
                  60                  65                  70

 ttc ctg cac gaa agc ccg gga gag gat agg cta ttt cgc gtc ctg gac      654
 Phe Leu His Glu Ser Pro Gly Glu Asp Arg Leu Phe Arg Val Leu Asp
              75                  80                  85

 tct ctc cag cat tcg cca tgg cag tgc tac ccc acc cag gac act cgg      702
 Ser Leu Gln His Ser Pro Trp Gln Cys Tyr Pro Thr Gln Asp Thr Arg
          90                  95                 100

 gga agg ctg tgt ccc tac ttt ttt gcc aat cag gag ttc tac agc ctg      750
 Gly Arg Leu Cys Pro Tyr Phe Phe Ala Asn Gln Glu Phe Tyr Ser Leu
     105                 110                 115

 gac agt cag ctg ccc atc tgg ggg gtg agg cag gtg cac tgt ggc tcc      798
 Asp Ser Gln Leu Pro Ile Trp Gly Val Arg Gln Val His Cys Gly Ser
 120                 125                 130                 135

 gag atc ctg agg gtg acg ctg tac tgc agt ttt gat aac tat gaa gac      846
 Glu Ile Leu Arg Val Thr Leu Tyr Cys Ser Phe Asp Asn Tyr Glu Asp
                 140                 145                 150

 gcc atc aga ctc tac gag atg atc ctg cag aga gaa gcg acc ttg caa      894
 Ala Ile Arg Leu Tyr Glu Met Ile Leu Gln Arg Glu Ala Thr Leu Gln
             155                 160                 165

 aag agc aat ttt tgt ttc ttc gtg ctc tat gcc tcc aag agc ttt gct      942
 Lys Ser Asn Phe Cys Phe Phe Val Leu Tyr Ala Ser Lys Ser Phe Ala
         170                 175                 180

 ctg cag ctc tcc ctg aag cag ctg ccc ccg gga atg tca gtg gac ccc      990
 Leu Gln Leu Ser Leu Lys Gln Leu Pro Pro Gly Met Ser Val Asp Pro
     185                 190                 195

 aaa gag tct tcg gtg ctg cag ttt aag gtt caa gag atc ggc cag tta     1038
 Lys Glu Ser Ser Val Leu Gln Phe Lys Val Gln Glu Ile Gly Gln Leu
 200                 205                 210                 215

 gtg cct ctg cta ccc aat cca tgc atg cct atc agc agc acc agg tgg     1086
 Val Pro Leu Leu Pro Asn Pro Cys Met Pro Ile Ser Ser Thr Arg Trp
                 220                 225                 230

 cag act cag gac tac gat ggc aac aag att ctg ctt cag cca ggc atc     1134
 Gln Thr Gln Asp Tyr Asp Gly Asn Lys Ile Leu Leu Gln Pro Gly Ile
             235                 240                 245

 cgc cag ggt cgc cag ctg gct gct agc agc tct gag ggt tac atc ctt     1182
 Arg Gln Gly Arg Gln Leu Ala Ala Ser Ser Ser Glu Gly Tyr Ile Leu
         250                 255                 260

 cat gtg gat tcc aag tgc ctt gcc cca cca tgg cgc aac aaa atg tct     1230
 His Val Asp Ser Lys Cys Leu Ala Pro Pro Trp Arg Asn Lys Met Ser
     265                 270                 275

 gga ctt cag tta gac caa cta gga tca gat tct ctt ctc taa             1272
 Gly Leu Gln Leu Asp Gln Leu Gly Ser Asp Ser Leu Leu 
 280                 285                 290





      <210> 214
      <211> 827
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(247)

      <400> 214
 agtgatgaaa gctatatgga cccttcgctt tgttatataa cat  atg cac aca tac      55
                                                  Met His Thr Tyr
                                                    1

 cca gaa ttt tgc aca tat gtt cag aga ttc cta gac ctg cag acc tgc      103
 Pro Glu Phe Cys Thr Tyr Val Gln Arg Phe Leu Asp Leu Gln Thr Cys
   5                  10                  15                  20

 ctc tgt gtg tcc caa ttt aag aac ctc tgt tct ttc ttc atg act gga      151
 Leu Cys Val Ser Gln Phe Lys Asn Leu Cys Ser Phe Phe Met Thr Gly
                  25                  30                  35

 ttt gcc caa ttt tgt gtt att ttg gga ctt aat ttg tcc ctc ttt ggg      199
 Phe Ala Gln Phe Cys Val Ile Leu Gly Leu Asn Leu Ser Leu Phe Gly
              40                  45                  50

 aca ttt cct tat tta ttg ccc tct tca gag agt aga tgt aga aaa taa      247
 Thr Phe Pro Tyr Leu Leu Pro Ser Ser Glu Ser Arg Cys Arg Lys 
          55                  60                  65

 agagaggaaa cctagattac ttaattttat tttaacattt tctatagata gcataccacg    307

 ccaagtgtgc tctgtcttga tccccttctt tctagcatct gccagacatt gtagagtttc    367

 gcaagcagtt gtaggtttga gctgcagcca gtcatttctt ttattcttta aaagtacata    427

 gatttgtctt tttagggctt tactgaaagt aaaatatcct gacatttaaa ctgacagatg    487

 taggaggtaa aaaatagagt tctgaaacat ttgaatttat gtgacagctg aagtcacgag    547

 atgagggatg tatgtccccc agggaggatg cagaaagaag aaaagggtac tggaaacagc    607

 atgtcagtgg tgccagctga gggctggagg cagccaggag agttgggagc ctgggtgctg    667

 ggtggagaga ggttaacagg gaagacatgg gaagtattgt gaaggctggt gtgagcaggg    727

 gactactcca gccctgttgg aacatagagc catttggcag attgacaatg cagtgacagc    787

 tgtatataat aaatgtgttg aaaggagaaa aaaaaaaaaa                          827




      <210> 215
      <211> 949
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (98)..(790)

      <400> 215
 tagaaaccgt tgatgggact gagaaaccag agttaaaacc tctttggagc ttctgaggac     60

 tcagctggaa ccaacgggca cagttggcaa caccatc atg aca tca caa cct gtt     115
                                          Met Thr Ser Gln Pro Val
                                            1               5

 ccc aat gag acc atc ata gtg ctc cca tca aat gtc atc aac ttc tcc      163
 Pro Asn Glu Thr Ile Ile Val Leu Pro Ser Asn Val Ile Asn Phe Ser
              10                  15                  20

 caa gca gag aaa ccc gaa ccc acc aac cag ggg cag gat agc ctg aag      211
 Gln Ala Glu Lys Pro Glu Pro Thr Asn Gln Gly Gln Asp Ser Leu Lys
          25                  30                  35

 aaa cat cta cac gca gaa atc aaa gtt att ggg act atc cag atc ttg      259
 Lys His Leu His Ala Glu Ile Lys Val Ile Gly Thr Ile Gln Ile Leu
      40                  45                  50

 tgt ggc atg atg gta ttg agc ttg ggg atc att ttg gca tct gct tcc      307
 Cys Gly Met Met Val Leu Ser Leu Gly Ile Ile Leu Ala Ser Ala Ser
  55                  60                  65                  70

 ttc tct cca aat ttt acc caa gtg act tct aca ctg ttg aac tct gct      355
 Phe Ser Pro Asn Phe Thr Gln Val Thr Ser Thr Leu Leu Asn Ser Ala
                  75                  80                  85

 tac cca ttc ata gga ccc ttt ttt ttt atc atc tct ggc tct cta tca      403
 Tyr Pro Phe Ile Gly Pro Phe Phe Phe Ile Ile Ser Gly Ser Leu Ser
              90                  95                 100

 atc gcc aca gag aaa agg ttg acc aag ctt ttg gtg cat agc agc ctg      451
 Ile Ala Thr Glu Lys Arg Leu Thr Lys Leu Leu Val His Ser Ser Leu
         105                 110                 115

 gtt gga agc att ctg agt gct ctg tct gcc ctg gtg ggt ttc att atc      499
 Val Gly Ser Ile Leu Ser Ala Leu Ser Ala Leu Val Gly Phe Ile Ile
     120                 125                 130

 ctg tct gtc aaa cag gcc acc tta aat cct gcc tca ctg cag tgt gag      547
 Leu Ser Val Lys Gln Ala Thr Leu Asn Pro Ala Ser Leu Gln Cys Glu
 135                 140                 145                 150

 ttg gac aat acc acg gac tgc tat aca gcc aaa gcc agt ctg gct gga      595
 Leu Asp Asn Thr Thr Asp Cys Tyr Thr Ala Lys Ala Ser Leu Ala Gly
                 155                 160                 165

 tct ctc tct ctg atg ctg att tgc act ctg ctg gaa ttc tgc cta gct      643
 Ser Leu Ser Leu Met Leu Ile Cys Thr Leu Leu Glu Phe Cys Leu Ala
             170                 175                 180

 gtg ctc act gct gtg ctg cgg tgg aaa cag gct tac tct gac ttc cct      691
 Val Leu Thr Ala Val Leu Arg Trp Lys Gln Ala Tyr Ser Asp Phe Pro
         185                 190                 195

 ggg agt gta ctt ttc ctg cct cac agt tac att ggt aat tct ggc atg      739
 Gly Ser Val Leu Phe Leu Pro His Ser Tyr Ile Gly Asn Ser Gly Met
     200                 205                 210

 tcc tca aaa atg act cat gac tgt gga tat gaa gaa cta ttg act tct      787
 Ser Ser Lys Met Thr His Asp Cys Gly Tyr Glu Glu Leu Leu Thr Ser
 215                 220                 225                 230

 taa gaaa aaagggagaa atattaatca gaaagttgat tcttatgata atatggaaaa      844
 


 gttaaccatt atagaaaagc aaagcttgag tttcctaaat gtaagctttt aaagtaatga    904

 acattaaaaa aaaccattat ttcactgtca tttaaaaaaa aaaaa                    949




      <210> 216
      <211> 814
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (98)..(655)

      <400> 216
 tagaaaccgt tgatgggact gagaaaccag agttaaaacc tctttggagc ttctgaggac     60

 tcagctggaa ccaacgggca cagttggcaa caccatc atg aca tca caa cct gtt     115
                                          Met Thr Ser Gln Pro Val
                                            1               5

 ccc aat gag acc atc ata gtg ctc cca tca aat gtc atc aac ttc tcc      163
 Pro Asn Glu Thr Ile Ile Val Leu Pro Ser Asn Val Ile Asn Phe Ser
              10                  15                  20

 caa gca gag aaa ccc gaa ccc acc aac cag ggg cag gat agc ctg aag      211
 Gln Ala Glu Lys Pro Glu Pro Thr Asn Gln Gly Gln Asp Ser Leu Lys
          25                  30                  35

 aaa cat cta cac gca gaa atc aaa gtt att ggg ttt atc atc tct ggc      259
 Lys His Leu His Ala Glu Ile Lys Val Ile Gly Phe Ile Ile Ser Gly
      40                  45                  50

 tct cta tca atc gcc aca gag aaa agg ttg acc aag ctt ttg gtg cat      307
 Ser Leu Ser Ile Ala Thr Glu Lys Arg Leu Thr Lys Leu Leu Val His
  55                  60                  65                  70

 agc agc ctg gtt gga agc att ctg agt gct ctg tct gcc ctg gtg ggt      355
 Ser Ser Leu Val Gly Ser Ile Leu Ser Ala Leu Ser Ala Leu Val Gly
                  75                  80                  85

 ttc att atc ctg tct gtc aaa cag gcc acc tta aat cct gcc tca ctg      403
 Phe Ile Ile Leu Ser Val Lys Gln Ala Thr Leu Asn Pro Ala Ser Leu
              90                  95                 100

 cag tgt gag ttg gac aat acc acg gac tgc tat aca gcc aaa gcc agt      451
 Gln Cys Glu Leu Asp Asn Thr Thr Asp Cys Tyr Thr Ala Lys Ala Ser
         105                 110                 115

 ctg gct gga tct ctc tct ctg atg ctg att tgc act ctg ctg gaa ttc      499
 Leu Ala Gly Ser Leu Ser Leu Met Leu Ile Cys Thr Leu Leu Glu Phe
     120                 125                 130

 tgc cta gct gtg ctc act gct gtg ctg cgg tgg aaa cag gct tac tct      547
 Cys Leu Ala Val Leu Thr Ala Val Leu Arg Trp Lys Gln Ala Tyr Ser
 135                 140                 145                 150

 gac ttc cct ggg agt gta ctt ttc ctg cct cac agt tac att ggt aat      595
 Asp Phe Pro Gly Ser Val Leu Phe Leu Pro His Ser Tyr Ile Gly Asn
                 155                 160                 165

 tct ggc atg tcc tca aaa atg act cat gac tgt gga tat gaa gaa cta      643
 Ser Gly Met Ser Ser Lys Met Thr His Asp Cys Gly Tyr Glu Glu Leu
             170                 175                 180

 ttg act tct taa gaa aaaagggaga aatattaatc agaaagttga ttcttatgat      698
 Leu Thr Ser 
         185

 aatatggaaa agttaaccat tatagaaaag caaagcttga gtttcctaaa tgtaagcttt    758

 taaagtaatg aacattaaaa aaaaccatta tttcactgtc atttaaaaaa aaaaaa        814




      <210> 217
      <211> 2154
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (545)..(1225)

      <400> 217
 ctcgcgtagg cacttctccg agcgtgacgt gcggactccg ctccactgcg gcccgcccgc     60

 ccgccggtct agccgccgcc tccttcgctc cctgagcacg ccaggcgagg gtcagctgcc    120

 ggggcgacgc ggcgcggaga gggcgggcgg gggggctgtg ggagcgccgg tctctatatg    180

 gcggcggctc tgtcgggcct ggctgtccgg ctctcgcgct cggccgccgc ccgctcctat    240

 ggggtcttct gcaaggggct gactcgcacg ctgctcatct tcttcgacct ggcctggcgg    300

 ctgcgtatca acttccccta cctctacatc gtggcttcca tgatgctcaa cgtccgcctg    360

 caggttcata ttgagatcca ttgaaggccc tcccagactg acgaaggcgt gacctcaggc    420

 ccaccgcatc caagaacacg aagcatgagg gacagaagag ggccccctcg gcacctgcct    480

 ggcacaagtg cagcaggccg gaggaggtga ctcggacaaa ctatcatgca gccttaagaa    540

 aaga atg ccg gag ggc cct tgg cct gca gat gca ccc tcc tgg atg aat     589
      Met Pro Glu Gly Pro Trp Pro Ala Asp Ala Pro Ser Trp Met Asn
        1               5                  10                  15

 aag cct gtg gtt gat gga aat tca caa agt gag gca tta tca ctg gaa      637
 Lys Pro Val Val Asp Gly Asn Ser Gln Ser Glu Ala Leu Ser Leu Glu
                  20                  25                  30

 atg aga aag gat ccg agc ggg gct ggc ctc tgg ctt cac agt ggc ggc      685
 Met Arg Lys Asp Pro Ser Gly Ala Gly Leu Trp Leu His Ser Gly Gly
              35                  40                  45

 cca gtg ctt cca tat gtg aga gaa tca gta aga aga aat cca gcc tca      733
 Pro Val Leu Pro Tyr Val Arg Glu Ser Val Arg Arg Asn Pro Ala Ser
          50                  55                  60

 gca gcc act ccg agc aca gcc gtg ggt ttg ttc cct gct cca aca gag      781
 Ala Ala Thr Pro Ser Thr Ala Val Gly Leu Phe Pro Ala Pro Thr Glu
      65                  70                  75

 tgt ttt gct cgg gtg tcc tgc agt ggt gtt gaa gct ctg ggg cag cga      829
 Cys Phe Ala Arg Val Ser Cys Ser Gly Val Glu Ala Leu Gly Gln Arg
  80                  85                  90                  95

 gac tgg ctg gga gga ggg ccc agg gcc act gac ggc cac aga gga cag      877
 Asp Trp Leu Gly Gly Gly Pro Arg Ala Thr Asp Gly His Arg Gly Gln
                 100                 105                 110

 tgc ccc aaa gga gag cct cgg gtg tca cga ctg cca cgc cat caa aaa      925
 Cys Pro Lys Gly Glu Pro Arg Val Ser Arg Leu Pro Arg His Gln Lys
             115                 120                 125

 ctg ccg gaa atg gga agt ttt cag gat gac cca cca agt gct ttt ccc      973
 Leu Pro Glu Met Gly Ser Phe Gln Asp Asp Pro Pro Ser Ala Phe Pro
         130                 135                 140

 aag ggt ctg ggc tct gag ttg gaa ccc gct tgc ctg cac tcc atc ctg     1021
 Lys Gly Leu Gly Ser Glu Leu Glu Pro Ala Cys Leu His Ser Ile Leu
     145                 150                 155

 tct gca acg ctg cac atg tat ccc gaa gtg ctc ctg agt gag gag aca     1069
 Ser Ala Thr Leu His Met Tyr Pro Glu Val Leu Leu Ser Glu Glu Thr
 160                 165                 170                 175

 aaa cgc att ttc ctt gat cgt tta aag ccc atg ttt tca aag caa aca     1117
 Lys Arg Ile Phe Leu Asp Arg Leu Lys Pro Met Phe Ser Lys Gln Thr
                 180                 185                 190

 ata gaa ttc aag aaa atg ctt aaa agc acc tca gat ggt ctg cag ata     1165
 Ile Glu Phe Lys Lys Met Leu Lys Ser Thr Ser Asp Gly Leu Gln Ile
             195                 200                 205

 aca ctg ggg tta ctg gct ctg caa cct ttt gaa tta gca aat aca tta     1213
 Thr Leu Gly Leu Leu Ala Leu Gln Pro Phe Glu Leu Ala Asn Thr Leu
         210                 215                 220

 tgc cat agt taa ggt acaagcagaa caataccaat agattaattt taagagttgt     1268
 Cys His Ser 
     225

 cttagaatga tttctttcgc attaagtctg gatgcaaact gtgcagccct taggttcctg   1328

 ctgtagtttt gtacgacctg gcagacttaa agtaaattga gtttaaattc aaagccagtt   1388

 gatgcggaag gaactttttt ggcatgtgtt aaattgtgct ttaaaagaca tataaagaat   1448

 tgggaaacat ttcaggagac gatcatagcc tgtataaata ccagattaga acatacggat   1508

 ttaccatgaa gttctgtctt caacatccat tctaaagggc tactgtccca aatcctgtgt   1568

 gtccttttga cttgtctgat cacccaatgg aagtggatac ttgtaaagtc tacaccactg   1628

 tacttggcgt taaatcttgc tgaattcgtg gtaagctgtt accatgtcta cattttgtag   1688

 aatgattttg gtctgcagca aaattcgatt tcacttctca tacccctttc cttccacttg   1748

 aaatgcaatt tagacagagg ccctgtggtg aaagttgcaa tattaagttt acctttagaa   1808

 gatcccttct caaactcaga accctagcag tgttacctta aacaaaaatg agctcgagaa   1868

 aaaagtagct cagttacaga gaagcaaatc gagttatttc ccacataaaa agtttcccag   1928

 attctaagaa ttgcagtatc ctgtacccta aaatttttca aggtgactcc tgttgtcgtc   1988

 tgttgataac tttaataaag gtcatttaag gacataagtt tttaaagact cccaaagtga   2048

 aacttaaaca ttttcgggat tatcgattgc atatatcagt ttatgctgtg tgctgaatta   2108

 ctatgccatg tgctatttta gtgtttgggg aaaatgaaaa ataaaa                  2154




      <210> 218
      <211> 1095
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (324)..(809)

      <400> 218
 cccagcttgc aaccccgcag ctagcctacc cagagccagg agacaagagt aatgaacctg     60

 aagatgctgg gaccagagac ccagacccca ctccagaggg agcctggcag tcagacagca    120

 gctctggaag cagagccctg gatgaagcag tggacgagca gctgttccgc tccgtggagg    180

 gccaggccgc ctctgacgag gaggaggtgg aggaggagag gtggcaggag gagaagaaga    240

 cgccggcagc cgaggccaag acactgctgg cccggctctc cagctgcaga ggcaggtgtg    300

 atgaccagac ggcggagaag ctc    atg act tac ttt ggt cac ttc ggc ggt     350
                              Met Thr Tyr Phe Gly His Phe Gly Gly
                                1               5

 gcc aac cat gcc cat acc ctg ggg gag ctg gag gcc tgc att gcc atg      398
 Ala Asn His Ala His Thr Leu Gly Glu Leu Glu Ala Cys Ile Ala Met
  10                  15                  20                  25

 ctg gtg gag cag ctg agg act cag ggc tgc ggt ggg agg acc ctg ggg      446
 Leu Val Glu Gln Leu Arg Thr Gln Gly Cys Gly Gly Arg Thr Leu Gly
                  30                  35                  40

 acc tct gag gag gag gca gag ttg cag cag aag gtg gaa gag aat gag      494
 Thr Ser Glu Glu Glu Ala Glu Leu Gln Gln Lys Val Glu Glu Asn Glu
              45                  50                  55

 cac ctg agg ctg gag ctg cag atg gta gag acc gag agg gtg cgg ctg      542
 His Leu Arg Leu Glu Leu Gln Met Val Glu Thr Glu Arg Val Arg Leu
          60                  65                  70

 tcc ctg ctg gag gag aag ctg gtg gac gtg ctg cag ctc ctg cag agg      590
 Ser Leu Leu Glu Glu Lys Leu Val Asp Val Leu Gln Leu Leu Gln Arg
      75                  80                  85

 ctc cgg gac ctg aac ata tcg aaa aga gcc ctg ggg aag att ttg ctg      638
 Leu Arg Asp Leu Asn Ile Ser Lys Arg Ala Leu Gly Lys Ile Leu Leu
  90                  95                 100                 105

 agc acg ctg gac gct ttc agg gac ccc acc cac gag gga agg ccc agc      686
 Ser Thr Leu Asp Ala Phe Arg Asp Pro Thr His Glu Gly Arg Pro Ser
                 110                 115                 120

 cct gca gcc atc ctg gat gcc ctg cac caa gcc ttg gct gcc tgc cag      734
 Pro Ala Ala Ile Leu Asp Ala Leu His Gln Ala Leu Ala Ala Cys Gln
             125                 130                 135

 ctg ttg cgg aga cag ccc tcg gca cca gcc tct gca gca gct gcg ctc      782
 Leu Leu Arg Arg Gln Pro Ser Ala Pro Ala Ser Ala Ala Ala Ala Leu
         140                 145                 150

 acc aac ccc ctc ctc gtc tcc tgc tga ggtta ctggcccacc ctgtgggcac      834
 Thr Asn Pro Leu Leu Val Ser Cys 
     155                 160

 cctgctcagc ctgactgcct ttggaccagc ctccatgatc agcccaacca ctgacagctg    894

 gtctgaccac cgtcacatca tcagaacttg agtctctgct ggctccttcc aaggttaagc    954

 ccgagcccag agcctcccat tgcagcacct ggcagccacc ccttcctcgg gctcctccac   1014

 attacctcgc agcccctgca ttcctgccac cagagtccac attaaagccc tgcagttgct   1074

 ggatcagaaa aaaaaaaaaa a                                             1095




      <210> 219
      <211> 1194
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (137)..(667)

      <400> 219
 gggaagagat ttaggctagg tacgaaggcg gggaggcggc ggtggcggcg gtggcggctg     60

 ggtcgggccc cgacgggcgg cggcggctga ggtggaggcg gagggaggcg gcggcggcgg    120

 cggcggcggc gggaag    atg gcg gct ccc gtc ctg cta aga gtg tcg gtg     169
                      Met Ala Ala Pro Val Leu Leu Arg Val Ser Val
                        1               5                  10

 ccg cgg tgg gag cgg gtg gcc cgg tat gca gtg tgc gct gcc gga atc      217
 Pro Arg Trp Glu Arg Val Ala Arg Tyr Ala Val Cys Ala Ala Gly Ile
              15                  20                  25

 ctg ctc tcc atc tac gcc tac cac gtg gag cgg gag aag gag cgg gac      265
 Leu Leu Ser Ile Tyr Ala Tyr His Val Glu Arg Glu Lys Glu Arg Asp
          30                  35                  40

 ccc gag cac cgg gcc ctc tgc gac ctg ggg ccc tgg gtg aag tgc tcc      313
 Pro Glu His Arg Ala Leu Cys Asp Leu Gly Pro Trp Val Lys Cys Ser
      45                  50                  55

 gcc gcc ctt gcc tcc aga tgg ggt cga gga ttt ggt ctt ttg ggt tcc      361
 Ala Ala Leu Ala Ser Arg Trp Gly Arg Gly Phe Gly Leu Leu Gly Ser
  60                  65                  70                  75

 att ttt gga aag gat ggt gta tta aac cag cca aac agt gtc ttt gga      409
 Ile Phe Gly Lys Asp Gly Val Leu Asn Gln Pro Asn Ser Val Phe Gly
                  80                  85                  90

 ctt ata ttt tat ata cta cag tta tta ctt ggc atg aca gca agc gct      457
 Leu Ile Phe Tyr Ile Leu Gln Leu Leu Leu Gly Met Thr Ala Ser Ala
              95                 100                 105

 gtg gcg gct ttg atc ctc atg acg tcc tcc atc atg tcg gtc gtg ggg      505
 Val Ala Ala Leu Ile Leu Met Thr Ser Ser Ile Met Ser Val Val Gly
         110                 115                 120

 tcc ctg tac ctg gcc tac att ctg tac ttt gtg ctg aag gag ttc tgc      553
 Ser Leu Tyr Leu Ala Tyr Ile Leu Tyr Phe Val Leu Lys Glu Phe Cys
     125                 130                 135

 atc atc tgc atc gtc acg tac gtg ctg aac ttc ctt ctt ctc att atc      601
 Ile Ile Cys Ile Val Thr Tyr Val Leu Asn Phe Leu Leu Leu Ile Ile
 140                 145                 150                 155

 aac tac aaa cga cta gtt tac ttg aac gag gcc tgg aag cgg cag ctg      649
 Asn Tyr Lys Arg Leu Val Tyr Leu Asn Glu Ala Trp Lys Arg Gln Leu
                 160                 165                 170

 caa ccc aag cag gac tga cgcccg acagactcca ccctaacagt ctcaagcccc      703
 Gln Pro Lys Gln Asp 
             175

 tttccattca gtttattttg cagcaggttt ttattattat tattattatt attattcaca    763

 acagacactt tccctaagaa tctcaaactg atttttaaaa atccggtaaa ttagaagggg    823

 ccctcgctat tttctgtgtc agtcttcatt ttaaatatgg atacaaaaag gatacgccga    883

 gccaatcaaa gacaagcttt aactttactt tgaagtgttt ctgaaatgat aaaatgtagc    943

 cctagccccc tgccctcaat tgtaaagtga gcaaccattg ctagtaattc tttaatgtgt   1003

 ataaattcaa tttcaggtat aacaaatgtg atcatgacat gaaaatattc tagaatagat   1063

 actgtattaa atattgccat gtttacaata tgtaatatgt ttttagccga tggatttaaa   1123

 catgtagatt caactagaat ccatttgtga tatttgtaaa taaaggtaga aatattaaaa   1183

 aaaaaaaaaa a                                                        1194




      <210> 220
      <211> 2029
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (401)..(1219)

      <400> 220
 atggaacaga aaacgaaaac aataacagaa tttggaaaca ttgctggatg cactcgagcc     60

 cctggttctt atttctgtca gagcaaagtg tcccaaggtg ttggggactg tatttgcata    120

 cacctgatcc taaatgaatg tgagtgcttt ggaaagcctg atgcatctcc acatcccagc    180

 gcccaggtga gggtatctgg tgcccggcag gtgtttgctg aacgcctcat gactgccttt    240

 caggccagcg aaggctgttg tgatagggtc aagggaaggg tctctttaca tcgcattcaa    300

 caaggggcca atcctgctgg cgcaggcaag gaggctgctc agcgactgac ggggaaatga    360

 gggtggggtg tgggcacgcg ctccggaggc tgcaggcgcc  atg ggc aga gtg agg     415
                                              Met Gly Arg Val Arg
                                                1               5

 aac cgc gcc act gct cag cgg cgg agg cga aag cgg ccc ggg gat cct      463
 Asn Arg Ala Thr Ala Gln Arg Arg Arg Arg Lys Arg Pro Gly Asp Pro
                  10                  15                  20

 ccc gcc gcc tgc gcg gcc atc gcg gtc acg ggc gcc agc cgc gcg cag      511
 Pro Ala Ala Cys Ala Ala Ile Ala Val Thr Gly Ala Ser Arg Ala Gln
              25                  30                  35

 tgc ccc cgg gtc caa gtc ggg gtc ggg agc cac gcg gcg gcc aag agg      559
 Cys Pro Arg Val Gln Val Gly Val Gly Ser His Ala Ala Ala Lys Arg
          40                  45                  50

 tgg ctg ggt agg tgg cga cgg aag cgc cgc tgg cgg cgg gtc cgg aag      607
 Trp Leu Gly Arg Trp Arg Arg Lys Arg Arg Trp Arg Arg Val Arg Lys
      55                  60                  65

 gcg ggc ccc aga gac ctg ctg ccc tcc gcg cca acc ccg gac ccg ccg      655
 Ala Gly Pro Arg Asp Leu Leu Pro Ser Ala Pro Thr Pro Asp Pro Pro
  70                  75                  80                  85

 ggg ccc gcc ccg tcc ccc aag gat ctg gac ctg ggc gca cag cgg gag      703
 Gly Pro Ala Pro Ser Pro Lys Asp Leu Asp Leu Gly Ala Gln Arg Glu
                  90                  95                 100

 cgc tgg gag acg ttc agg aag ctg cgg ggc ctc agc tgc gag ggc gcc      751
 Arg Trp Glu Thr Phe Arg Lys Leu Arg Gly Leu Ser Cys Glu Gly Ala
             105                 110                 115

 gcc aag gtc ctg ctg gac acc ttc gag tac ccg ggc ctc gtg cat cac      799
 Ala Lys Val Leu Leu Asp Thr Phe Glu Tyr Pro Gly Leu Val His His
         120                 125                 130

 acc ggg ggc tgc cac tgc ggc gcg gtc cgc ttt gcg gtc tgg gcc cct      847
 Thr Gly Gly Cys His Cys Gly Ala Val Arg Phe Ala Val Trp Ala Pro
     135                 140                 145

 gca gat ctg cgc gtc gtg gat tgc agc tgc agg ctg tgc agg aag aag      895
 Ala Asp Leu Arg Val Val Asp Cys Ser Cys Arg Leu Cys Arg Lys Lys
 150                 155                 160                 165

 cag cac cgc cac ttc ctc gtc ccg gcc tcg cgc ttc acg ctg ctc cag      943
 Gln His Arg His Phe Leu Val Pro Ala Ser Arg Phe Thr Leu Leu Gln
                 170                 175                 180

 ggc gca gaa agc atc gtc acc tat cgg tcc aac acg cac ccg gcg ctg      991
 Gly Ala Glu Ser Ile Val Thr Tyr Arg Ser Asn Thr His Pro Ala Leu
             185                 190                 195

 cac agc ttc tgc agc agg tgc ggg gtg cag agt ttc cac gca gct gtc     1039
 His Ser Phe Cys Ser Arg Cys Gly Val Gln Ser Phe His Ala Ala Val
         200                 205                 210

 tct gac ccc cgc gtg tac ggc gtc gcc ccg cac tgc ctg gac gag ggc     1087
 Ser Asp Pro Arg Val Tyr Gly Val Ala Pro His Cys Leu Asp Glu Gly
     215                 220                 225

 acc gtg cgc agc gtg gtc atc gag gag gtc ggc ggt ggc gac ccg ggg     1135
 Thr Val Arg Ser Val Val Ile Glu Glu Val Gly Gly Gly Asp Pro Gly
 230                 235                 240                 245

 gag gag gcc gcc aag gag cac aag gcc atc cac aag acg tcc tcc cag     1183
 Glu Glu Ala Ala Lys Glu His Lys Ala Ile His Lys Thr Ser Ser Gln
                 250                 255                 260

 tca gcc cct gcc tgt ccc cgc gaa cag gag cag tga ttgg ggccgcaagc     1233
 Ser Ala Pro Ala Cys Pro Arg Glu Gln Glu Gln 
             265                 270

 ccgcctgaaa ccggcccggg cggccctgcg gggagcgtcc gagtacctgc acagatccca   1293

 tgctgtgaaa gaggtgtttc tggcctggtc acaccgggga ttcccttcca gtatttgccc   1353

 ttcccctccg ctagttttca gtgaactcgc ttacgatcca aatcttgaac acacctttgt   1413

 ctgcgtagta caacgttaat cttgcaattc ggtaaggaag aagagtgtct ctgatttttc   1473

 aaaccatcca ttgtatctct cgcttttact gttctgccta cagttgtcac aaatcacctg   1533

 cagatgattc ctgtgtactg tacgttcctg gtgctattgt gaacaggctt gttgttttca   1593

 gcgctttgcc tctggtgtgt aggacggcaa cacacaacca gtttgtaaac atgtgctagg   1653

 acgtcttcca ttgattatgg tgtgcgtggg ctcccgcacc tgtgagtttc aggtagacgt   1713

 tcatattttc actgcttaga ttcgagttat gctatttact ggtttttaaa tgatatattt   1773

 caagatttgg tcgtgttaca tacctcatta ctctttattt cctgtaacag cgaaagctgt   1833

 tactatttcg cttgttgttt gggaagtgtc tctgggtaag gagatgggga tacaggaatg   1893

 agaaagacat ctgtgcacac aggaatgaga aagacatctg cgcactgtct gccctcttta   1953

 atcttttgaa atacctgtct tgtacatgtg ttaagtatat agaaatcagt aaataccttc   2013

 taggaaaaaa aaaaaa                                                   2029




      <210> 221
      <211> 1339
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (189)..(824)

      <400> 221
 ggtcgacgtt ttcgtccaag agtcgcgtgc gcggcccctt gcaccatccc cccgggccca     60

 cccccgggcc gcgctgattg ggcaggtagg gactctgccc agcggaaagt tttgggtgcc    120

 gggaggaagt ctaacctttg ggagactcca agacagcagc tccgaggtcg gcgggggtct    180

 gggtggcc atg gag gag ccc cct gtg cga gaa gag gaa gag gag gag gga     230
          Met Glu Glu Pro Pro Val Arg Glu Glu Glu Glu Glu Glu Gly
            1               5                  10

 gag gag gac gag gag agg gac gag gtt ggg ccc gag ggg gcg ctg ggc      278
 Glu Glu Asp Glu Glu Arg Asp Glu Val Gly Pro Glu Gly Ala Leu Gly
  15                  20                  25                  30

 aag agc ccc ttc cag ctg acc gcc gag gac gtg tat gac atc tcc tac      326
 Lys Ser Pro Phe Gln Leu Thr Ala Glu Asp Val Tyr Asp Ile Ser Tyr
                  35                  40                  45

 ctg ttg ggc cgc gag ctt atg gcc ctg ggc agc gac ccc cgg gtg acg      374
 Leu Leu Gly Arg Glu Leu Met Ala Leu Gly Ser Asp Pro Arg Val Thr
              50                  55                  60

 cag ctg cag ttc aaa gtc gtc cgc gtc ctg gag atg ctg gag gcg ctg      422
 Gln Leu Gln Phe Lys Val Val Arg Val Leu Glu Met Leu Glu Ala Leu
          65                  70                  75

 gtg aat gag ggc agc ctg gcg ctg gag gag ctg aag atg gag agg gac      470
 Val Asn Glu Gly Ser Leu Ala Leu Glu Glu Leu Lys Met Glu Arg Asp
      80                  85                  90

 cac ctc agg aag gag gtg gag ggg ctg cgg aga cag agc cct ccg gcc      518
 His Leu Arg Lys Glu Val Glu Gly Leu Arg Arg Gln Ser Pro Pro Ala
  95                 100                 105                 110

 agc ggg gag gtg aac ctg ggc cca aac aaa atg gtg gtt gac ctg aca      566
 Ser Gly Glu Val Asn Leu Gly Pro Asn Lys Met Val Val Asp Leu Thr
                 115                 120                 125

 gat ccc aac cga ccc cgc ttc act ctg cag gag cta agg gat gtg ctg      614
 Asp Pro Asn Arg Pro Arg Phe Thr Leu Gln Glu Leu Arg Asp Val Leu
             130                 135                 140

 cag gaa cgc aac aaa ctc aag tcg cag ctc ctg gtg gtg cag gaa gag      662
 Gln Glu Arg Asn Lys Leu Lys Ser Gln Leu Leu Val Val Gln Glu Glu
         145                 150                 155

 ctg cag tgc tac aag agt ggc ctg att cca cca aga gaa ggc cca gga      710
 Leu Gln Cys Tyr Lys Ser Gly Leu Ile Pro Pro Arg Glu Gly Pro Gly
     160                 165                 170

 gga aga aga gaa aaa gat gct gtg gtt act agt gcc aaa aat gct ggc      758
 Gly Arg Arg Glu Lys Asp Ala Val Val Thr Ser Ala Lys Asn Ala Gly
 175                 180                 185                 190

 agg aac aag gag gag aag aca atc ata aaa aag ctg ttc ttt ttt cga      806
 Arg Asn Lys Glu Glu Lys Thr Ile Ile Lys Lys Leu Phe Phe Phe Arg
                 195                 200                 205

 tcg ggg aaa cag acc tag atccaa ggccacaagt aaggctatgg ctctgattct      860
 Ser Gly Lys Gln Thr 
             210

 agaagacaac cttccaagat gcctggcaaa accacctccc tgtgccacac agacacacta    920

 ggcctgtgta tttatttccc cttcaaagca gactgaggag ggaggagacg aggttctctt    980

 ggcatcactt tctccctggc tgcagaacta gacacccttg aagatttggc ctgggccagt   1040

 gagactgaaa tcaagaaaaa cagaagggat gtgcagggtg ggggggtcca cttcctgctc   1100

 ccatgtcaac ccccagggcc tccagcgtgc agacgcgtgt cctactcatc tgctcccacg   1160

 gatgaccctg gtcttcaatg gttagcagaa gggagaaaag aaagcaggaa aatgtgctat   1220

 tgagattcca gtggtgactt cactgatatt tagtgaatat ttgatttagc caacatgcct   1280

 ttctttatgt gattttgtat taaagtaaaa tgatttttat actttcaaaa aaaaaaaaa    1339




      <210> 222
      <211> 1074
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (91)..(618)

      <400> 222
 ggcaagactt cagtgcagaa gagcagctat gagcccctgt ggaatgagca ggtcgtcttt     60

 acagacctct tccccccact ctgcaaacgc     atg aag gtg cag atc cga gac     111
                                      Met Lys Val Gln Ile Arg Asp
                                        1               5

 tcg gac aag gtc aac gac gtg gcc atc ggc acc cac ttc att gac ctg      159
 Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr His Phe Ile Asp Leu
          10                  15                  20

 cgc aag att tct aat gac gga gac aaa ggt cag cag cgg gag acc cgg      207
 Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Gln Gln Arg Glu Thr Arg
      25                  30                  35

 tgt gct ggg ggg cag agg gag tgg cct gaa ggg aag gaa tat gtc aac      255
 Cys Ala Gly Gly Gln Arg Glu Trp Pro Glu Gly Lys Glu Tyr Val Asn
  40                  45                  50                  55

 cct ttc aga gac cgt atc tgc aga gtg ttc tcc cac aaa ggc atg ttc      303
 Pro Phe Arg Asp Arg Ile Cys Arg Val Phe Ser His Lys Gly Met Phe
                  60                  65                  70

 tcc ttt gag gat gtg ctg ggc atg gca tct gtg ttc agc gag cag gcc      351
 Ser Phe Glu Asp Val Leu Gly Met Ala Ser Val Phe Ser Glu Gln Ala
              75                  80                  85

 tgc cca agc ctg aag att gag tat gcc ttt cgc atc tat gcc tgg ggc      399
 Cys Pro Ser Leu Lys Ile Glu Tyr Ala Phe Arg Ile Tyr Ala Trp Gly
          90                  95                 100

 cct tca ctg atc tgt ggc tcc acc acc ccc acc gtg atc ggc agg tac      447
 Pro Ser Leu Ile Cys Gly Ser Thr Thr Pro Thr Val Ile Gly Arg Tyr
     105                 110                 115

 cag ggg cca cgg tcc cca ctg tgg cct tct cct ttg gcg ctc cct acg      495
 Gln Gly Pro Arg Ser Pro Leu Trp Pro Ser Pro Leu Ala Leu Pro Thr
 120                 125                 130                 135

 gca cca cca ccc tca agt act tcc agg acc acc gca aca gag cca tgg      543
 Ala Pro Pro Pro Ser Ser Thr Ser Arg Thr Thr Ala Thr Glu Pro Trp
                 140                 145                 150

 aga aga gcc aca ctc cct tca gcc aag gcg gcc att tcc cca cca tct      591
 Arg Arg Ala Thr Leu Pro Ser Ala Lys Ala Ala Ile Ser Pro Pro Ser
             155                 160                 165

 tct cca cca acc cca acc tcc tgc tga tggag cgcgccagca cccgggaccg      643
 Ser Pro Pro Thr Pro Thr Ser Cys 
         170                 175

 ctggctgcac aagcccagct acactcgctt caacctggac agccatcgct ccacagagct    703

 tacgaatttc taccagatgg tccagcagca tcggaagtac tatcaagaca agacgggcac    763

 agtgcctcga gtcccctact ttgcgatgcc cgtgagggag ccggaacggt accccctccc    823

 caccgtcctg cctcctctgt gcccaaagaa gaagtggcac cttttaagac tagcccccga    883

 gaacctgaag acctaccaga ccttcccatc agggaagagg gtctctccac aggagcggaa    943

 aaagagagac tgctactttg agttcagagc atgagacttt tagttcagag cagagcctga   1003

 tgcctgagat cctgggtcgt gaccagcctg gcttgcttgg aataaaatct ttagccatga   1063

 aaaaaaaaaa a                                                        1074




      <210> 223
      <211> 862
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (122)..(535)

      <400> 223
 cgcttccgga agtgggtctc gtctcctccc aagcggagca tttgtgcctg aagctgccgg     60

 gtctgctacg gcaccgcggg gctgcagaaa cccgggggcc aagggcgggc tgcttgccgc    120

 t    atg gct ggc agt cag gac ata ttc gat gcc atc gtg atg gcg gat     166
      Met Ala Gly Ser Gln Asp Ile Phe Asp Ala Ile Val Met Ala Asp
        1               5                  10                  15

 gag agg ttt cat ggg gaa ggg tat cgg gaa ggc tat gaa gaa ggc agt      214
 Glu Arg Phe His Gly Glu Gly Tyr Arg Glu Gly Tyr Glu Glu Gly Ser
                  20                  25                  30

 agt ttg ggt gtg atg gag gga agg cag cat ggc acg ctg cat gga gcc      262
 Ser Leu Gly Val Met Glu Gly Arg Gln His Gly Thr Leu His Gly Ala
              35                  40                  45

 aaa atc ggg tct gag atc ggg tgc tac caa ggt ttt gct ttt gca tgg      310
 Lys Ile Gly Ser Glu Ile Gly Cys Tyr Gln Gly Phe Ala Phe Ala Trp
          50                  55                  60

 aaa tgt cta ctg cac agt tgc acc act gag aag gac agc aga aag atg      358
 Lys Cys Leu Leu His Ser Cys Thr Thr Glu Lys Asp Ser Arg Lys Met
      65                  70                  75

 aag gtc tta gaa tca ttg att gga atg atc cag aaa ttc cct tat gat      406
 Lys Val Leu Glu Ser Leu Ile Gly Met Ile Gln Lys Phe Pro Tyr Asp
  80                  85                  90                  95

 gac cct act tac gat aaa ctc cat gaa gac tta gac aag atc aga gga      454
 Asp Pro Thr Tyr Asp Lys Leu His Glu Asp Leu Asp Lys Ile Arg Gly
                 100                 105                 110

 aaa ttt aaa cag ttt tgt tcg tta ctc aat gtt cag cca gac ttt aaa      502
 Lys Phe Lys Gln Phe Cys Ser Leu Leu Asn Val Gln Pro Asp Phe Lys
             115                 120                 125

 att agt gca gaa ggt tcc gga ctt tca ttt tga ggaggatg gatgaacaga      553
 Ile Ser Ala Glu Gly Ser Gly Leu Ser Phe 
         130                 135

 gaccgaacgt cgaggaacag atgtgtgtgt gacgtgttta gaaatgcggt gaagggccag    613

 acggtgctgg gaaggcagtt gttcattggg agggtgaggg ttccggttcg gccgtgggag    673

 ggcttccttc cctggggttt tctgcctgtg tcaccttggt gcccgtcttg gggcctctcc    733

 acacatgccc tttgttgggc tgaagccgtc cctggcagag ccctcgtgca ttgacttgac    793

 agcctctccg gcagcacagg cctagctggt tctgggttgg agttggctct ggatagggtt    853

 agtcaccag                                                            862




      <210> 224
      <211> 1237
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (379)..(867)

      <400> 224
 atgaataact tttcacataa tttcagcagg ttcatcgcct cctgagttca catggacccc     60

 cttgggaatt tatggacacc cccgcccagg ttaggaaaac ctgctcttgt gtgggttgct    120

 tcaaacaagt ttaaatttgc cttctcctag ttgtccatag atctaagctt tttctaaaag    180

 tcccatggaa cttgtaatga gacctctaaa tgtcccatat cccaaaatgc tgttgtaggc    240

 ttcttagatt ttggaagacc agatcagcaa aagacagcat gcactcaggt ggaatattgc    300

 aaaggtagac atcagctcaa ggctagcttc tctgggcagc tggtgcaagc aggcttccgg    360

 ccctgcgcac agacccaa  atg gcg cgg gag gag gaa gaa ggg gtc agc ttc     411
                      Met Ala Arg Glu Glu Glu Glu Gly Val Ser Phe
                        1               5                  10

 aag cct gac gtt cta ggg ggg agc cgc ttc tta agg tct gct gac cct      459
 Lys Pro Asp Val Leu Gly Gly Ser Arg Phe Leu Arg Ser Ala Asp Pro
              15                  20                  25

 gcc cac atc tgt ccc cag gac ccg cac agc atc atc ttc ctc tgt gac      507
 Ala His Ile Cys Pro Gln Asp Pro His Ser Ile Ile Phe Leu Cys Asp
          30                  35                  40

 ctc cac atc cac ttc cca gct gga gtc atc gat gcc att cgg aag cac      555
 Leu His Ile His Phe Pro Ala Gly Val Ile Asp Ala Ile Arg Lys His
      45                  50                  55

 tgt gtg gag gga aag atg gcc ttt gcc ccc atg gtg atg agg ctg cat      603
 Cys Val Glu Gly Lys Met Ala Phe Ala Pro Met Val Met Arg Leu His
  60                  65                  70                  75

 tgt ggg gcc acc ccc cag tgg cct gag ggc tac tgg gag gtg aat ggg      651
 Cys Gly Ala Thr Pro Gln Trp Pro Glu Gly Tyr Trp Glu Val Asn Gly
                  80                  85                  90

 ttc ggg ctg ctt ggc atc tac aag tct gac ctg gac agg att ggg ggc      699
 Phe Gly Leu Leu Gly Ile Tyr Lys Ser Asp Leu Asp Arg Ile Gly Gly
              95                 100                 105

 atg aac acc aag gag ttc cga gac cgc tgg ggc ggg gaa gac tgg gag      747
 Met Asn Thr Lys Glu Phe Arg Asp Arg Trp Gly Gly Glu Asp Trp Glu
         110                 115                 120

 ctg ctg gac agg ata ctc caa gcg ggc ctg gac gtg gag cgt ctc tcc      795
 Leu Leu Asp Arg Ile Leu Gln Ala Gly Leu Asp Val Glu Arg Leu Ser
     125                 130                 135

 ctc agg aat ttc ttc cat cat ttc cat tcc aag cga ggc atg tgg agc      843
 Leu Arg Asn Phe Phe His His Phe His Ser Lys Arg Gly Met Trp Ser
 140                 145                 150                 155

 cgt cgc cag atg aag acg ctg tag ccggagggtg tccgcggggc ccagcactcc     897
 Arg Arg Gln Met Lys Thr Leu 
                 160

 ccgctctgga ctagcagtgg ctccccaggg ccctgctact gttcagggat ggggagtggg    957

 gtgacggctg gaccccaaga ggcctcgaag ctgacggccc actccacctg gagctgtccc   1017

 ctcacagagg caggttccgg ggctcctgtc tctgcctcct gggccttcag aagggaggac   1077

 tttgagagag aggccaggag ggaccacttg ctctctcgac gtctgtaaag cgctggtcag   1137

 atagatctgg gtctggaagg cgctatatga gtgatcggcc cccgcctcct ccagtacgta   1197

 tgccctgtgg cgcctggata gccccgggaa ttcggaccgg                         1237




      <210> 225
      <211> 818
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(511)

      <400> 225
 tttcgtcggg gagggggaag cctcgcctgg ggggcggcag tggcctgggc ggctctccgg     60

 ctgctgttgt   atg gct gca cgt tgg cgc tac cgg acg gga tgc tgt atc     109
              Met Ala Ala Arg Trp Arg Tyr Arg Thr Gly Cys Cys Ile
                1               5                  10

 ccc gag aga gcc cgt cgt ggc agc gca agc agc tgg acg gcc tct gaa      157
 Pro Glu Arg Ala Arg Arg Gly Ser Ala Ser Ser Trp Thr Ala Ser Glu
      15                  20                  25

 gct tcc gcg ccg act tct ccg aca acc gac gcc ggg gct tcg agg agc      205
 Ala Ser Ala Pro Thr Ser Pro Thr Thr Asp Ala Gly Ala Ser Arg Ser
  30                  35                  40                  45

 aga ggt acc ggc gac cgc tgt cgg agg cgc gga ctc ggg gca ggg cca      253
 Arg Gly Thr Gly Asp Arg Cys Arg Arg Arg Gly Leu Gly Ala Gly Pro
                  50                  55                  60

 gga gtc gcc cgg aag ccc ggc ggt ggg aat ggg tca ggc ccc acc gtg      301
 Gly Val Ala Arg Lys Pro Gly Gly Gly Asn Gly Ser Gly Pro Thr Val
              65                  70                  75

 gac atg ccg gtt ccc tcc agc ttc aac gac atc ggc cag ggc tgg cgg      349
 Asp Met Pro Val Pro Ser Ser Phe Asn Asp Ile Gly Gln Gly Trp Arg
          80                  85                  90

 ctg cgg cat ttt gtc agc tgg ttg tgg tat gaa cgg gag gtg acc ctg      397
 Leu Arg His Phe Val Ser Trp Leu Trp Tyr Glu Arg Glu Val Thr Leu
      95                 100                 105

 ctg gag cga tgg atc cag gac ctg tgc aca aga gtg gtg ctg agg att      445
 Leu Glu Arg Trp Ile Gln Asp Leu Cys Thr Arg Val Val Leu Arg Ile
 110                 115                 120                 125

 ggc agt gcc cac ttc tat gcc atc gtg gta tcc caa ggg tta ctt tgt      493
 Gly Ser Ala His Phe Tyr Ala Ile Val Val Ser Gln Gly Leu Leu Cys
                 130                 135                 140

 cca gaa cac aga ctt tga cttctt cagctacgca ggactgctgt ggtctctgct      547
 Pro Glu His Arg Leu 
             145

 tctatacacg acacccccca cctacatcga tgacgtcacc gtcaccaccg gcgtgaagcg    607

 agacagtggt gagggcttct ggactggatg gaggacctga agacgtgagg tggaggcaca    667

 ggtagaagag aagattctca ccatcgctga ttcacacaaa agcatttctc caagtggttg    727

 cagatgacat gatttcccaa agtgttagag ctgaagtgtg tttccttgtg tatatatact    787

 gtggttcctt tatcccttca tctgtggata g                                   818




      <210> 226
      <211> 4097
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1725)..(3068)

      <400> 226
 atggcccccg cggctgggcg gggcgcggcc gcccaaaggc gctgcctttc tggaagcttt     60

 gttcccattt tagcgtctga gagcttgcag ccggctggga aggccccctt ggtccgtctg    120

 gccctttcgg ggaagaggcc aacactcggc acacgcgatc cacggcagag gggagccttg    180

 ggcgcgcaga attggctgcg ccccgccgag agcctcctgt gggtggggag agcccctcca    240

 cccctctgct cgcttgagcg ctcagagccc agggccgccg accgcagcac tttccgattt    300

 gctgcaccga gggcccgcgg tccctgtgtg cggtttccac cgttgttgga ggcggccgca    360

 ggcgaaccgt cgggtcgtca gccacgaccc gagtcaggca tctccccgct cctgggaccg    420

 gggccgaagg ccaatcacac tgcagctagg tcttgcgatt ggacggcagt gagagccgat    480

 tggccgccgc cgcgagtttc gggctccctc cctctccctt ttgccccaac tccagcgcct    540

 aagcttcagg ccaatgagac agcgctttat agacgccctc ccttcgcttt cttctcccca    600

 ccttggagag ggaggggaag tcctgactgg ccagactgtc ctcggaagcc cccttctctt    660

 caccaatcac cgaaggaggt acgctcccag cggagttttc cagccaatca caaagcggcg    720

 gcggcgccca gccgtgcagt ttcaccagcg tctctgggtt tcaccgtcct caactcttca    780

 agcctcttcg taagggccgg cgactctgat tggccactgt tgccattgtc gaatgtctcc    840

 tccagccagc caccgaacaa ggcgaattca ccctttccgt tcggctacct tcggcatttt    900

 ccgctctttg ggcgtggctt cccagcgtca ctttctaatt ggtttctcag gctgatcggc    960

 tttttccggg aggagccgca aacaaacgac gtccgtgatt ggctccgttc gggcttcggc   1020

 tcccagccga agcgggcgag cgtggggctc ggccggcgat tcccagacgc ctgttacgcg   1080

 ggcggcgggg cgctgggcgg tgtaaggctg ggtgggggag gaaggaggtg gaggacgagt   1140

 aggagggggg aggaggagtg gggaagtgca aggcggctgc gcagacagcg ctcctcacac   1200

 agagcagccc ctgacccggg cgaatgcggg cttgtgccgc cgccgccgcc gccgccgccc   1260

 gggccaagtg acaaaggaag gaaggaagcg aggaggagcc ggccccgcag ccgctgacag   1320

 ggctctgggc tggggcaaag cgcggacact tcctcaccat cggcgacgcg aacggcgaga   1380

 tccagcggca cgcggagcag caggcgctgc gcctcgaggt gcgcgccggc ccggactcgg   1440

 cgggcatcgc cctctacagc catgaagatg tgtgtgtctt taagtgctca gtgtcccgag   1500

 agacagagtg cagccgtgtg ggcaagcagt ccttcatcat caccctgggc tgcaacagcg   1560

 tcctcatcca gttcgccaca cccaacgatt tctgttcctt ctacaacatc ctgaaaacct   1620

 gccggggcca caccctggag cggtctgtgt tcagcgagcg gacggaggag tcttctgccg   1680

 tgcagtactt ccagttttat ggctacctgt cccagcagca gaac atg atg cag gac    1736
                                                  Met Met Gln Asp
                                                    1

 tac gtg cgg aca ggc acc tac cag cgc gcc atc ctg caa aac cac acc     1784
 Tyr Val Arg Thr Gly Thr Tyr Gln Arg Ala Ile Leu Gln Asn His Thr
   5                  10                  15                  20

 gac ttc aag gac aag atc gtt ctt gat gtt ggc tgt ggc tct ggg atc     1832
 Asp Phe Lys Asp Lys Ile Val Leu Asp Val Gly Cys Gly Ser Gly Ile
                  25                  30                  35

 ctg tcg ttt ttt gcc gcc caa gct gga gca cgg aaa atc tac gcg gtg     1880
 Leu Ser Phe Phe Ala Ala Gln Ala Gly Ala Arg Lys Ile Tyr Ala Val
              40                  45                  50

 gag gcc agc acc atg gcc cag cac gct gag gtc ttg gtg aag agt aac     1928
 Glu Ala Ser Thr Met Ala Gln His Ala Glu Val Leu Val Lys Ser Asn
          55                  60                  65

 aac ctg acg gac cgc atc gtg gtc atc ccg ggc aag gtg gag gag gtg     1976
 Asn Leu Thr Asp Arg Ile Val Val Ile Pro Gly Lys Val Glu Glu Val
      70                  75                  80

 tca ctc ccc gag cag gtg gac atc atc atc tcg gag ccc atg ggc tac     2024
 Ser Leu Pro Glu Gln Val Asp Ile Ile Ile Ser Glu Pro Met Gly Tyr
  85                  90                  95                 100

 atg ctc ttc aac gag cgc atg ctg gag agc tac ctc cac gcc aag aag     2072
 Met Leu Phe Asn Glu Arg Met Leu Glu Ser Tyr Leu His Ala Lys Lys
                 105                 110                 115

 tac ctg aag ccc agc gga aac atg ttt cct acc att ggt gac gtc cac     2120
 Tyr Leu Lys Pro Ser Gly Asn Met Phe Pro Thr Ile Gly Asp Val His
             120                 125                 130

 ctt gca ccc ttc acg gat gaa cag ctc tac atg gag cag ttc acc aag     2168
 Leu Ala Pro Phe Thr Asp Glu Gln Leu Tyr Met Glu Gln Phe Thr Lys
         135                 140                 145

 gcc aac ttc tgg tac cag cca tct ttc cat gga gtg gac ctg tcg gcc     2216
 Ala Asn Phe Trp Tyr Gln Pro Ser Phe His Gly Val Asp Leu Ser Ala
     150                 155                 160

 ctc cga ggt gcc gcg gtg gat gag tat ttc cgg cag cct gtg gtg gac     2264
 Leu Arg Gly Ala Ala Val Asp Glu Tyr Phe Arg Gln Pro Val Val Asp
 165                 170                 175                 180

 aca ttt gac atc cgg atc ctg atg gcc aag tct gtc aag tac acg gtg     2312
 Thr Phe Asp Ile Arg Ile Leu Met Ala Lys Ser Val Lys Tyr Thr Val
                 185                 190                 195

 aac ttc tta gaa gcc aaa gaa gga gat ttg cac agg ata gaa atc cca     2360
 Asn Phe Leu Glu Ala Lys Glu Gly Asp Leu His Arg Ile Glu Ile Pro
             200                 205                 210

 ttc aaa ttc cac atg ctg cat tca ggg ctg gtc cac ggc ctg gct ttc     2408
 Phe Lys Phe His Met Leu His Ser Gly Leu Val His Gly Leu Ala Phe
         215                 220                 225

 tgg ttt gac gtt gct ttc atc ggc tcc ata atg acc gtg tgg ctg tcc     2456
 Trp Phe Asp Val Ala Phe Ile Gly Ser Ile Met Thr Val Trp Leu Ser
     230                 235                 240

 aca gcc ccg aca gag ccc ctg acc cac tgg tac cag gtg cgg tgc ctg     2504
 Thr Ala Pro Thr Glu Pro Leu Thr His Trp Tyr Gln Val Arg Cys Leu
 245                 250                 255                 260

 ttc cag tca cca ctg ttc gcc aag gca ggg gac acg ctc tca ggg aca     2552
 Phe Gln Ser Pro Leu Phe Ala Lys Ala Gly Asp Thr Leu Ser Gly Thr
                 265                 270                 275

 tgt ctg ctt att gcc aac aaa aga cag agc tac gac atc agt att gtg     2600
 Cys Leu Leu Ile Ala Asn Lys Arg Gln Ser Tyr Asp Ile Ser Ile Val
             280                 285                 290

 gcc cag gtg gac cag acc ggc tcc aag tcc agt aac ctc ctg gat ctg     2648
 Ala Gln Val Asp Gln Thr Gly Ser Lys Ser Ser Asn Leu Leu Asp Leu
         295                 300                 305

 aaa aac ccc ttc ttt aga tac acg ggc aca acg ccc tca ccc cca ccc     2696
 Lys Asn Pro Phe Phe Arg Tyr Thr Gly Thr Thr Pro Ser Pro Pro Pro
     310                 315                 320

 ggc tcc cac tac aca tct ccc tcg gaa aac atg tgg aac acg ggc agc     2744
 Gly Ser His Tyr Thr Ser Pro Ser Glu Asn Met Trp Asn Thr Gly Ser
 325                 330                 335                 340

 acc tac aac ctc agc agc ggg atg gcc gtg gca ggg atg ccg acc gcc     2792
 Thr Tyr Asn Leu Ser Ser Gly Met Ala Val Ala Gly Met Pro Thr Ala
                 345                 350                 355

 tat gac ttg agc agt gtt att gcc agt ggc tcc agc gtg ggc cac aac     2840
 Tyr Asp Leu Ser Ser Val Ile Ala Ser Gly Ser Ser Val Gly His Asn
             360                 365                 370

 aac ctg att cct tta gcc aac acg ggg att gtc aat cac acc cac tcc     2888
 Asn Leu Ile Pro Leu Ala Asn Thr Gly Ile Val Asn His Thr His Ser
         375                 380                 385

 cgg atg ggc tcc ata atg agc acg ggg att gtc caa ggg tcc tcc ggc     2936
 Arg Met Gly Ser Ile Met Ser Thr Gly Ile Val Gln Gly Ser Ser Gly
     390                 395                 400

 gcc cag ggc agt ggt ggt ggc agc acg agt gcc cac tat gca gtc aac     2984
 Ala Gln Gly Ser Gly Gly Gly Ser Thr Ser Ala His Tyr Ala Val Asn
 405                 410                 415                 420

 agc cag ttc acc atg ggc ggc ccc gcc atc tcc atg gcg tcg ccc atg     3032
 Ser Gln Phe Thr Met Gly Gly Pro Ala Ile Ser Met Ala Ser Pro Met
                 425                 430                 435

 tcc atc ccg acc aac acc atg cac tac ggg agc tag gggc ccgccccgcg     3082
 Ser Ile Pro Thr Asn Thr Met His Tyr Gly Ser 
             440                 445

 gactgacagc accaggaaac caaatgatgt ccctgcccgc cgcccccgcc gggcggcttt   3142

 cccccttgta ctggagaagc tcgaacaccc ggtcacagct ctctttgcta tgggaactgg   3202

 gacacttttt taccgatgtg cggggcgttc cccaacctaa cccccacctc ccggccctga   3262

 gcgtgtgtcg ctgccatatt ttacacaaaa tcatgttgtg ggagccctcg tcccccctcc   3322

 tgcccgctct accctgacct gggcttgtca tctgctggaa caggcgccat ggggccctgc   3382

 cagccctgcc tgccaggtcc cttagcacct gtccccctgc ctgtctccag tgggaaggta   3442

 gcctggccag gcggggcctc cccttcgacg accaggcctc ggtcacaacg gacgtgacat   3502

 gctgcttttt ttaattttat ttttttatga aaagaaccag tgtcaatccg cagaccctct   3562

 gtgaagccag gccggccggg ccgagccagc agcccctctc cctagactca gaggcgccgc   3622

 ggggaggggt ggccccgccg aggcttcagg ggccccctcc ccaccaaagg gttcacctca   3682

 cacttgaatg tacaacccac cccactgtcg ggaaggcctc cgtcctcggc ccctgcctct   3742

 tgctgctgtc ctgtccccga gcccctgcag gtcccccccc gcccccccac tcaagagtta   3802

 gagcaggtgg ctgcaggcct tgggcccgga gggaaggcca ctgccggcca cttggggcag   3862

 acacagacac ctcaaggatc tgtcacggaa ggcgtccttt ttccttgtag ctaacgttag   3922

 gcctgagtag ctcccctcca tccttgtaga cgctccagtc cctactactg tgacggcatt   3982

 tccatccctc ccctgcccgg gaagggacct tgcagggacc tctccctcca aaaaaagaaa   4042

 aaaagaaaaa gaaagaaaaa ataaatgagg aaacgtgttg caaaaaaaaa aaaaa        4097




      <210> 227
      <211> 2844
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (426)..(1814)

      <400> 227
 atgaagatgt gtgtgtcttt aagtgctcag tgtcccgaga gacagagtgc agccgtgtgg     60

 gcaagcagtc cttcatcatc accctgggct gcaacagcgt cctcatccag ttcgccacac    120

 ccaacgattt ctgttccttc tacaacatcc tgaaaacctg ccggggccac accctggagc    180

 ggtctgtgtt cagcgagcgg acggaggagt cttctgccgt gcagtacttc caggtccagg    240

 cggcatcagc tgttgccatc ggctgcagtg atagtggcgg tgtcctcctg ggggctgccc    300

 tccggcttcc tgctccctct cctggagctg ctagtggggc ccaggcagag ggtgcacgac    360

 ctcccgaggg agggctggcc agggccttgg ctgcctcgtg ccaccatgtg ccccgtgcca    420

 tcggt    atg tct ctg ttc cag ttt tat ggc tac ctg tcc cag cag cag     467
          Met Ser Leu Phe Gln Phe Tyr Gly Tyr Leu Ser Gln Gln Gln
            1               5                  10

 aac atg atg cag gac tac gtg cgg aca ggc acc tac cag cgc gcc atc      515
 Asn Met Met Gln Asp Tyr Val Arg Thr Gly Thr Tyr Gln Arg Ala Ile
  15                  20                  25                  30

 ctg caa aac cac acc gac ttc aag gac aag atc gtt ctt gat gtt ggc      563
 Leu Gln Asn His Thr Asp Phe Lys Asp Lys Ile Val Leu Asp Val Gly
                  35                  40                  45

 tgt ggc tct ggg atc ctg tcg ttt ttt gcc gcc caa gct gga gca cgg      611
 Cys Gly Ser Gly Ile Leu Ser Phe Phe Ala Ala Gln Ala Gly Ala Arg
              50                  55                  60

 aaa atc tac gcg gtg gag gcc agc acc atg gcc cag cac gct gag gtc      659
 Lys Ile Tyr Ala Val Glu Ala Ser Thr Met Ala Gln His Ala Glu Val
          65                  70                  75

 ttg gtg aag agt aac aac ctg acg gac cgc atc gtg gtc atc ccg ggc      707
 Leu Val Lys Ser Asn Asn Leu Thr Asp Arg Ile Val Val Ile Pro Gly
      80                  85                  90

 aag gtg gag gag gtg tca ctc ccc gag cag gtg gac atc atc atc tcg      755
 Lys Val Glu Glu Val Ser Leu Pro Glu Gln Val Asp Ile Ile Ile Ser
  95                 100                 105                 110

 gag ccc atg ggc tac atg ctc ttc aac gag cgc atg ctg gag agc tac      803
 Glu Pro Met Gly Tyr Met Leu Phe Asn Glu Arg Met Leu Glu Ser Tyr
                 115                 120                 125

 ctc cac gcc aag aag tac ctg aag ccc agc gga aac atg ttt cct acc      851
 Leu His Ala Lys Lys Tyr Leu Lys Pro Ser Gly Asn Met Phe Pro Thr
             130                 135                 140

 att ggt gac gtc cac ctt gca ccc ttc acg gat gaa cag ctc tac atg      899
 Ile Gly Asp Val His Leu Ala Pro Phe Thr Asp Glu Gln Leu Tyr Met
         145                 150                 155

 gag cag ttc acc aag gcc aac ttc tgg tac cag cca tct ttc cat gga      947
 Glu Gln Phe Thr Lys Ala Asn Phe Trp Tyr Gln Pro Ser Phe His Gly
     160                 165                 170

 gtg gac ctg tcg gcc ctc cga ggt gcc gcg gtg gat gag tat ttc cgg      995
 Val Asp Leu Ser Ala Leu Arg Gly Ala Ala Val Asp Glu Tyr Phe Arg
 175                 180                 185                 190

 cag cct gtg gtg gac aca ttt gac atc cgg atc ctg atg gcc aag tct     1043
 Gln Pro Val Val Asp Thr Phe Asp Ile Arg Ile Leu Met Ala Lys Ser
                 195                 200                 205

 gtc aag tac acg gtg aac ttc tta gaa gcc aaa gaa gga gat ttg cac     1091
 Val Lys Tyr Thr Val Asn Phe Leu Glu Ala Lys Glu Gly Asp Leu His
             210                 215                 220

 agg ata gaa atc cca ttc aaa ttc cac atg ctg cat tca ggg ctg gtc     1139
 Arg Ile Glu Ile Pro Phe Lys Phe His Met Leu His Ser Gly Leu Val
         225                 230                 235

 cac ggc ctg gct ttc tgg ttt gac gtt gct ttc atc ggc tcc ata atg     1187
 His Gly Leu Ala Phe Trp Phe Asp Val Ala Phe Ile Gly Ser Ile Met
     240                 245                 250

 acc gtg tgg ctg tcc aca gcc ccg aca gag ccc ctg acc cac tgg tac     1235
 Thr Val Trp Leu Ser Thr Ala Pro Thr Glu Pro Leu Thr His Trp Tyr
 255                 260                 265                 270

 cag gtg cgg tgc ctg ttc cag tca cca ctg ttc gcc aag gca ggg gac     1283
 Gln Val Arg Cys Leu Phe Gln Ser Pro Leu Phe Ala Lys Ala Gly Asp
                 275                 280                 285

 acg ctc tca ggg aca tgt ctg ctt att gcc aac aaa aga cag agc tac     1331
 Thr Leu Ser Gly Thr Cys Leu Leu Ile Ala Asn Lys Arg Gln Ser Tyr
             290                 295                 300

 gac atc agt att gtg gcc cag gtg gac cag acc ggc tcc aag tcc agt     1379
 Asp Ile Ser Ile Val Ala Gln Val Asp Gln Thr Gly Ser Lys Ser Ser
         305                 310                 315

 aac ctc ctg gat ctg aaa aac ccc ttc ttt aga tac acg ggc aca acg     1427
 Asn Leu Leu Asp Leu Lys Asn Pro Phe Phe Arg Tyr Thr Gly Thr Thr
     320                 325                 330

 ccc tca ccc cca ccc ggc tcc cac tac aca tct ccc tcg gaa aac atg     1475
 Pro Ser Pro Pro Pro Gly Ser His Tyr Thr Ser Pro Ser Glu Asn Met
 335                 340                 345                 350

 tgg aac acg ggc agc acc tac aac ctc agc agc ggg atg gcc gtg gca     1523
 Trp Asn Thr Gly Ser Thr Tyr Asn Leu Ser Ser Gly Met Ala Val Ala
                 355                 360                 365

 ggg atg ccg acc gcc tat gac ttg agc agt gtt att gcc agt ggc tcc     1571
 Gly Met Pro Thr Ala Tyr Asp Leu Ser Ser Val Ile Ala Ser Gly Ser
             370                 375                 380

 agc gtg ggc cac aac aac ctg att cct tta gcc aac acg ggg att gtc     1619
 Ser Val Gly His Asn Asn Leu Ile Pro Leu Ala Asn Thr Gly Ile Val
         385                 390                 395

 aat cac acc cac tcc cgg atg ggc tcc ata atg agc acg ggg att gtc     1667
 Asn His Thr His Ser Arg Met Gly Ser Ile Met Ser Thr Gly Ile Val
     400                 405                 410

 caa ggg tcc tcc ggc gcc cag ggc agt ggt ggt ggc agc acg agt gcc     1715
 Gln Gly Ser Ser Gly Ala Gln Gly Ser Gly Gly Gly Ser Thr Ser Ala
 415                 420                 425                 430

 cac tat gca gtc aac agc cag ttc acc atg ggc ggc ccc gcc atc tcc     1763
 His Tyr Ala Val Asn Ser Gln Phe Thr Met Gly Gly Pro Ala Ile Ser
                 435                 440                 445

 atg gcg tcg ccc atg tcc atc ccg acc aac acc atg cac tac ggg agc     1811
 Met Ala Ser Pro Met Ser Ile Pro Thr Asn Thr Met His Tyr Gly Ser
             450                 455                 460

 tag gggc ccgccccgcg gactgacagc accaggaaac caaatgatgt ccctgcccgc     1868
 


 cgcccccgcc gggcggcttt cccccttgta ctggagaagc tcgaacaccc ggtcacagct   1928

 ctctttgcta tgggaactgg gacacttttt taccgatgtg cggggcgttc cccaacctaa   1988

 cccccacctc ccggccctga gcgtgtgtcg ctgccatatt ttacacaaaa tcatgttgtg   2048

 ggagccctcg tcccccctcc tgcccgctct accctgacct gggcttgtca tctgctggaa   2108

 caggcgccat ggggccctgc cagccctgcc tgccaggtcc cttagcacct gtccccctgc   2168

 ctgtctccag tgggaaggta gcctggccag gcggggcctc cccttcgacg accaggcctc   2228

 ggtcacaacg gacgtgacat gctgcttttt ttaattttat ttttttatga aaagaaccag   2288

 tgtcaatccg cagaccctct gtgaagccag gccggccggg ccgagccagc agcccctctc   2348

 cctagactca gaggcgccgc ggggaggggt ggccccgccg aggcttcagg ggccccctcc   2408

 ccaccaaagg gttcacctca cacttgaatg tacaacccac cccactgtcg ggaaggcctc   2468

 cgtcctcggc ccctgcctct tgctgctgtc ctgtccccga gcccctgcag gtcccccccc   2528

 gcccccccac tcaagagtta gagcaggtgg ctgcaggcct tgggcccgga gggaaggcca   2588

 ctgccggcca cttggggcag acacagacac ctcaaggatc tgtcacggaa ggcgtccttt   2648

 ttccttgtag ctaacgttag gcctgagtag ctcccctcca tccttgtaga cgctccagtc   2708

 cctactactg tgacggcatt tccatccctc ccctgcccgg gaagggacct tgcagggacc   2768

 tctccctcca aaaaaagaaa aaaagaaaaa gaaagaaaaa ataaatgagg aaacgtgttg   2828

 caaaaaaaaa aaaaaa                                                   2844




      <210> 228
      <211> 728
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (139)..(399)

      <400> 228
 ccgaagcaaa ccccttttaa aatctaatgt ctgggctttg agtattagct catttagggc     60

 ggacaaatgc attactgttt tcaaactgct cacatttatt cagtatttct ccaagttgct    120

 atctactcag ccttatga  atg ccc ctc gct ttt cta agg cca tgt gaa aat     171
                      Met Pro Leu Ala Phe Leu Arg Pro Cys Glu Asn
                        1               5                  10

 cac ggc act gcc ctt agc ctt gtg tca tct gct ttt tcg ttc tgc gat      219
 His Gly Thr Ala Leu Ser Leu Val Ser Ser Ala Phe Ser Phe Cys Asp
              15                  20                  25

 atg ccc agt tcc caa atc aat tat agg tac ctg ttt agg aga gag gaa      267
 Met Pro Ser Ser Gln Ile Asn Tyr Arg Tyr Leu Phe Arg Arg Glu Glu
          30                  35                  40

 gat ttt acc tct caa agg gtg aga ttt gaa att tac act aaa aag aca      315
 Asp Phe Thr Ser Gln Arg Val Arg Phe Glu Ile Tyr Thr Lys Lys Thr
      45                  50                  55

 act tta cat tta atg ctt cac tta atg aga cat tct ttt ttt tat aag      363
 Thr Leu His Leu Met Leu His Leu Met Arg His Ser Phe Phe Tyr Lys
  60                  65                  70                  75

 tct att ttt cta ctc agt ttc aga aca cta atc tga tttt cactctgatt      413
 Ser Ile Phe Leu Leu Ser Phe Arg Thr Leu Ile 
                  80                  85

 tttaacgttt ctttaaatat ttataatgta gcttctttca aaatattttc atgaaaaatt    473

 acttttatta taccattatg tgcatgttat tggtagcagg catagtttat tatttagtac    533

 tgaaacatgc tcttttacct aacagtaaac aagtatgttt tgatatatat ctgttaatat    593

 gcttatagtg gtaagaaatg gacttgaggt cccaggagat ttcattttat tcaccctggt    653

 cagatacaat aaaggctatg agtataaata cataacttcc taaccaggtg tagggcatgt    713

 tcatgaatat caaat                                                     728




      <210> 229
      <211> 436
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (227)..(385)

      <400> 229
 acgaaatcgt cgacagcgag gagaaggcca gaattgagag accaggagca ctacagagaa     60

 tttccagagg caaattttga attgaggaca ctgtattata cggttactat agtaagtatc    120

 tttcagtttc tttccctatt tggactgcta accaaaatac tgatacgact ccgatgagtg    180

 gagaacccca ggttcttcct cttgggtcga attagaaaaa aatgac   atg gac aca     235
                                                      Met Asp Thr
                                                        1

 cat gga gta gtt tta agg agc agg gag ttt agt agg caa gaa aga agg      283
 His Gly Val Val Leu Arg Ser Arg Glu Phe Ser Arg Gln Glu Arg Arg
       5                  10                  15

 ggg aag aaa gaa ata agc tcc cct gta cag aga cag agg gag ggg agc      331
 Gly Lys Lys Glu Ile Ser Ser Pro Val Gln Arg Gln Arg Glu Gly Ser
  20                  25                  30                  35

 tcc aaa acc aag aga ggg aac ccc acc tgc cac gga tac cag tca ggt      379
 Ser Lys Thr Lys Arg Gly Asn Pro Thr Cys His Gly Tyr Gln Ser Gly
                  40                  45                  50

 ata tga agaggctgaa ggtgccagtg tttgatttgc atagggctcg ggattggttt       435
 Ile 


 g                                                                    436




      <210> 230
      <211> 1658
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (351)..(1424)

      <400> 230
 tcaatacagc aaaaagaaaa tgtacatttc tgaggctgtc gagaaccgtt cacacagcag     60

 cttccgaatc cgctcttgaa agagcggatc agaaagaaca cgcactcctc cgcgcaggga    120

 aatatgccgc acgcactcaa gggaccggcc gcgaaagtta gtgcgtgggc ggggcacagc    180

 gaagggggcc agggccttgc cggggcgggg ctggcgcccg gggcggtcgc gacgtagccc    240

 cgcccccagc gttggcgcga gatccgaacg tcggcggccg cggttctggc gttccctgag    300

 gcgccgggag cctgcgccgg cgtcctgccg gcttcgtctc ctcagcggcc   atg agg     356
                                                          Met Arg
                                                            1

 cgg aca ggc ccc gag gag gag gcc tgc ggc gtg tgg ctg gac gcg gcg      404
 Arg Thr Gly Pro Glu Glu Glu Ala Cys Gly Val Trp Leu Asp Ala Ala
           5                  10                  15

 gcg ctg aag agg cgg aaa gtg cag aca cat tta atc aaa cca ggc acc      452
 Ala Leu Lys Arg Arg Lys Val Gln Thr His Leu Ile Lys Pro Gly Thr
      20                  25                  30

 aaa atg cta aca ctc ctt cct gga gaa aga aag gct aat att tat ttt      500
 Lys Met Leu Thr Leu Leu Pro Gly Glu Arg Lys Ala Asn Ile Tyr Phe
  35                  40                  45                  50

 act caa aga aga gct cca tct aca ggc att cac cag aga agc att gct      548
 Thr Gln Arg Arg Ala Pro Ser Thr Gly Ile His Gln Arg Ser Ile Ala
                  55                  60                  65

 tcc ttc ttc acc ttg cag cca gga aag aca aat ggc agt gac cag aag      596
 Ser Phe Phe Thr Leu Gln Pro Gly Lys Thr Asn Gly Ser Asp Gln Lys
              70                  75                  80

 agt gtt tca tct cat aca gaa agt cag atc aac aaa gag tcc aag aaa      644
 Ser Val Ser Ser His Thr Glu Ser Gln Ile Asn Lys Glu Ser Lys Lys
          85                  90                  95

 aat gcg acc cag cta gac cat ttg atc cca ggc tta gca cac gat tgc      692
 Asn Ala Thr Gln Leu Asp His Leu Ile Pro Gly Leu Ala His Asp Cys
     100                 105                 110

 atg gca tcc cct tta gcc act tca acc act gca gac atc cag gaa gct      740
 Met Ala Ser Pro Leu Ala Thr Ser Thr Thr Ala Asp Ile Gln Glu Ala
 115                 120                 125                 130

 gga ctc tct cct cag tcc ctc cag act tct ggc cac cac aga atg aaa      788
 Gly Leu Ser Pro Gln Ser Leu Gln Thr Ser Gly His His Arg Met Lys
                 135                 140                 145

 acc cca ttt tca act gag cta tct ttg ctc cag cct gat act cca gac      836
 Thr Pro Phe Ser Thr Glu Leu Ser Leu Leu Gln Pro Asp Thr Pro Asp
             150                 155                 160

 tgt gct gga gat agt cat acc cca ctg gct ttt tcc ttc acc gag gac      884
 Cys Ala Gly Asp Ser His Thr Pro Leu Ala Phe Ser Phe Thr Glu Asp
         165                 170                 175

 ttg gaa agt tct tgt ttg cta gac cga aag gaa gaa aaa ggg gat tct      932
 Leu Glu Ser Ser Cys Leu Leu Asp Arg Lys Glu Glu Lys Gly Asp Ser
     180                 185                 190

 gcc agg aaa tgg gaa tgg ctt cat gag tct aag aag aac tat cag agt      980
 Ala Arg Lys Trp Glu Trp Leu His Glu Ser Lys Lys Asn Tyr Gln Ser
 195                 200                 205                 210

 atg gag aaa cac acc aaa cta cct ggg gac aaa tgc tgt cag ccc tta     1028
 Met Glu Lys His Thr Lys Leu Pro Gly Asp Lys Cys Cys Gln Pro Leu
                 215                 220                 225

 ggc aag act aaa ttg gaa aga aag gtg tct gcc aaa gaa aac agg cag     1076
 Gly Lys Thr Lys Leu Glu Arg Lys Val Ser Ala Lys Glu Asn Arg Gln
             230                 235                 240

 gcc cct gtc ctc ctt caa aca tac agg gaa tcc tgg aat gga gaa aac     1124
 Ala Pro Val Leu Leu Gln Thr Tyr Arg Glu Ser Trp Asn Gly Glu Asn
         245                 250                 255

 ata gaa tca gtg aaa caa agc cgt agt cca gtt tct gtg ttt tcc tgg     1172
 Ile Glu Ser Val Lys Gln Ser Arg Ser Pro Val Ser Val Phe Ser Trp
     260                 265                 270

 gac aat gaa aag aat gac aag gac tcc tgg agt caa ctt ttc act gaa     1220
 Asp Asn Glu Lys Asn Asp Lys Asp Ser Trp Ser Gln Leu Phe Thr Glu
 275                 280                 285                 290

 gat tct caa ggc cag cgg gtc att gcc cac aac act aga gct cct ttt     1268
 Asp Ser Gln Gly Gln Arg Val Ile Ala His Asn Thr Arg Ala Pro Phe
                 295                 300                 305

 caa gat gta acc aat aac tgg aat tgg gac tta ggg ccg ttt cct aac     1316
 Gln Asp Val Thr Asn Asn Trp Asn Trp Asp Leu Gly Pro Phe Pro Asn
             310                 315                 320

 agt cct tgg gct cag tgc cag gag gat ggg cca act caa aat ctg aag     1364
 Ser Pro Trp Ala Gln Cys Gln Glu Asp Gly Pro Thr Gln Asn Leu Lys
         325                 330                 335

 cct gat ttg ctc ttt acc cag gac tct gaa ggt aat caa gtt atc aga     1412
 Pro Asp Leu Leu Phe Thr Gln Asp Ser Glu Gly Asn Gln Val Ile Arg
     340                 345                 350

 cac caa ttc taa atg tttgaagctt tgtttctaaa agtaccttga aatgatagag     1467
 His Gln Phe 
 355

 atgtaggaaa atatagttgt gggtggagag aggagtgagt ttgtttaggt gggaaggtgg   1527

 catgggatga agttgtcatt actgagcatc ttctctgtgt aaataaaggg cagtaccatt   1587

 gttaagacag tgattagcaa atctccccac aacccaggtg tggagagaag agaggtagaa   1647

 tggtgctagc t                                                        1658




      <210> 231
      <211> 2785
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (323)..(2116)

      <400> 231
 ggaattcccg ggtcgacgat ttcgtcggag aggctggaga gaatcgtttg ggggcattcg     60

 cattttaaag aggggctggc cctcgacgcg ctcgggctcg attggccgcc ctcccccggc    120

 ggtggtaacg gtcgcggagg cggggcctga cgtagctgat cccagcctaa cctggcccgg    180

 ctggctgctg gtgggaggcc ggcgactgag taagatgaag atccagtttc agacatgaga    240

 ctcgttgggt gatcatttca ttgagatcaa cctgaatgac caggtgtaaa gtgcaagagt    300

 aatatgctat gactgagtaa ct atg ttt ccg gta gcc cct aaa ccc cag gat     352
                          Met Phe Pro Val Ala Pro Lys Pro Gln Asp
                            1               5                  10

 tcc agt caa cca tca gac aga ctc atg act gaa aaa cag cag gaa gaa      400
 Ser Ser Gln Pro Ser Asp Arg Leu Met Thr Glu Lys Gln Gln Glu Glu
                  15                  20                  25

 gca gaa tgg gaa agc ata aat gtg cta ttg atg atg cat ggc tta aaa      448
 Ala Glu Trp Glu Ser Ile Asn Val Leu Leu Met Met His Gly Leu Lys
              30                  35                  40

 cct ttg tct cta gtc aaa aga aca gat ctc aaa gat ctc atc att ttt      496
 Pro Leu Ser Leu Val Lys Arg Thr Asp Leu Lys Asp Leu Ile Ile Phe
          45                  50                  55

 gac aaa cag tca tca caa agg atg aga cag aat ttg aaa ttg ttg gtg      544
 Asp Lys Gln Ser Ser Gln Arg Met Arg Gln Asn Leu Lys Leu Leu Val
      60                  65                  70

 gaa gaa aca tca tgt caa cag aac atg ata cag gag ctt ata gaa act      592
 Glu Glu Thr Ser Cys Gln Gln Asn Met Ile Gln Glu Leu Ile Glu Thr
  75                  80                  85                  90

 aat caa cag ctt aga aat gaa ctt cag cta gag caa agc cga gca gcc      640
 Asn Gln Gln Leu Arg Asn Glu Leu Gln Leu Glu Gln Ser Arg Ala Ala
                  95                 100                 105

 aat caa gaa caa cga gct aat gac ttg gaa caa att atg gaa agt gtg      688
 Asn Gln Glu Gln Arg Ala Asn Asp Leu Glu Gln Ile Met Glu Ser Val
             110                 115                 120

 aaa tcc aaa att ggt gaa ttg gag gat gaa tca cta agt agg gct tgc      736
 Lys Ser Lys Ile Gly Glu Leu Glu Asp Glu Ser Leu Ser Arg Ala Cys
         125                 130                 135

 cac caa cag aat aaa ata aaa gat ctt caa aag gag cag aaa act tta      784
 His Gln Gln Asn Lys Ile Lys Asp Leu Gln Lys Glu Gln Lys Thr Leu
     140                 145                 150

 cag gtg aag tgc cag cat tat aag aaa aaa cga acg gag caa gaa gaa      832
 Gln Val Lys Cys Gln His Tyr Lys Lys Lys Arg Thr Glu Gln Glu Glu
 155                 160                 165                 170

 act att gct tct ttg caa atg gaa gtc tgt aga tta aaa aag gag gaa      880
 Thr Ile Ala Ser Leu Gln Met Glu Val Cys Arg Leu Lys Lys Glu Glu
                 175                 180                 185

 gaa gat cgc att gtc act caa aac aga gtg ttt gcc tat ctg tgc aaa      928
 Glu Asp Arg Ile Val Thr Gln Asn Arg Val Phe Ala Tyr Leu Cys Lys
             190                 195                 200

 aga gtt cct cat acc gtc ttg gat aga cag ttg ctt tgt cta att gat      976
 Arg Val Pro His Thr Val Leu Asp Arg Gln Leu Leu Cys Leu Ile Asp
         205                 210                 215

 tac tat gaa tct aaa att aga aaa att cat aca caa agg caa tat aaa     1024
 Tyr Tyr Glu Ser Lys Ile Arg Lys Ile His Thr Gln Arg Gln Tyr Lys
     220                 225                 230

 gaa gat gaa agt cag tca gaa gaa gaa aac gac tac aga aat ctg gat     1072
 Glu Asp Glu Ser Gln Ser Glu Glu Glu Asn Asp Tyr Arg Asn Leu Asp
 235                 240                 245                 250

 gcc tca cca act tat aaa ggc ctt tta atg tca tta cag aat caa ctc     1120
 Ala Ser Pro Thr Tyr Lys Gly Leu Leu Met Ser Leu Gln Asn Gln Leu
                 255                 260                 265

 aag gaa tca aaa tct aag att gat gca ctt tca agt gaa aag ctg aac     1168
 Lys Glu Ser Lys Ser Lys Ile Asp Ala Leu Ser Ser Glu Lys Leu Asn
             270                 275                 280

 ctc caa aaa gat ttg gaa acc agg cct aca cag cat gaa tta aga ctt     1216
 Leu Gln Lys Asp Leu Glu Thr Arg Pro Thr Gln His Glu Leu Arg Leu
         285                 290                 295

 tat aaa cag cag gtg aag aag ctg gaa aaa gcc ctt aag aaa aac gtc     1264
 Tyr Lys Gln Gln Val Lys Lys Leu Glu Lys Ala Leu Lys Lys Asn Val
     300                 305                 310

 aaa tta cag gag ctt att aat cat aag aag gct gag gac aca gag aag     1312
 Lys Leu Gln Glu Leu Ile Asn His Lys Lys Ala Glu Asp Thr Glu Lys
 315                 320                 325                 330

 aaa gat gag ccc agc aaa tat aat cag caa cag gcc cta att gac cag     1360
 Lys Asp Glu Pro Ser Lys Tyr Asn Gln Gln Gln Ala Leu Ile Asp Gln
                 335                 340                 345

 aga tac ttt cag gtg ctg tgt agc atc aat tca att atc cac aat cca     1408
 Arg Tyr Phe Gln Val Leu Cys Ser Ile Asn Ser Ile Ile His Asn Pro
             350                 355                 360

 aga gct cca gta ata att tat aaa cag acc aaa ggg gga gtc caa aat     1456
 Arg Ala Pro Val Ile Ile Tyr Lys Gln Thr Lys Gly Gly Val Gln Asn
         365                 370                 375

 ttt aat aaa gat ctt gtt caa gat tgt gga ttt gag cat ctt gtt cct     1504
 Phe Asn Lys Asp Leu Val Gln Asp Cys Gly Phe Glu His Leu Val Pro
     380                 385                 390

 gta ata gaa atg tgg gca gat caa ctg aca tcc tta aag gat ttg tat     1552
 Val Ile Glu Met Trp Ala Asp Gln Leu Thr Ser Leu Lys Asp Leu Tyr
 395                 400                 405                 410

 aag tcc ttg aaa aca cta tct gca gaa ctg gta cct tgg ctt aat ttg     1600
 Lys Ser Leu Lys Thr Leu Ser Ala Glu Leu Val Pro Trp Leu Asn Leu
                 415                 420                 425

 aag aag cag gat gaa aat gaa ggt atc aaa gtt gaa gat ttg ttg ttt     1648
 Lys Lys Gln Asp Glu Asn Glu Gly Ile Lys Val Glu Asp Leu Leu Phe
             430                 435                 440

 ata gta gat act atg ctg gaa gaa gtt gaa aat aag gaa aag gac agc     1696
 Ile Val Asp Thr Met Leu Glu Glu Val Glu Asn Lys Glu Lys Asp Ser
         445                 450                 455

 aat atg cca cac ttt caa act ttg caa gct att gtt tct cac ttc caa     1744
 Asn Met Pro His Phe Gln Thr Leu Gln Ala Ile Val Ser His Phe Gln
     460                 465                 470

 aag tta ttt gat gtg cct tct tta aat gga gtc tat ccc cga atg aat     1792
 Lys Leu Phe Asp Val Pro Ser Leu Asn Gly Val Tyr Pro Arg Met Asn
 475                 480                 485                 490

 gaa gtt tat act agg ctt gga gaa atg aac aat gct gtg aga aac ctc     1840
 Glu Val Tyr Thr Arg Leu Gly Glu Met Asn Asn Ala Val Arg Asn Leu
                 495                 500                 505

 caa gaa ctc tta gaa tta gat agt tca tcc tca ttg tgt gtg cta gta     1888
 Gln Glu Leu Leu Glu Leu Asp Ser Ser Ser Ser Leu Cys Val Leu Val
             510                 515                 520

 agc act gtt gga aaa ctc tgt agg ctg att aat gaa gat gtg aat gag     1936
 Ser Thr Val Gly Lys Leu Cys Arg Leu Ile Asn Glu Asp Val Asn Glu
         525                 530                 535

 cag gtt atg cag gta tta gga cct gaa gac ctc cag agc att atc tac     1984
 Gln Val Met Gln Val Leu Gly Pro Glu Asp Leu Gln Ser Ile Ile Tyr
     540                 545                 550

 aaa ttg gaa gaa cac gag gaa ttt ttc cca gca ttt cag gca ttt act     2032
 Lys Leu Glu Glu His Glu Glu Phe Phe Pro Ala Phe Gln Ala Phe Thr
 555                 560                 565                 570

 aat gat cta ctt gaa atc tta gaa att gat gac ttg gat gcc att gta     2080
 Asn Asp Leu Leu Glu Ile Leu Glu Ile Asp Asp Leu Asp Ala Ile Val
                 575                 580                 585

 cct gca gta aag aaa tta aaa gta ctt tca tac tga aaac aaatcaaatc     2130
 Pro Ala Val Lys Lys Leu Lys Val Leu Ser Tyr 
             590                 595

 atttttactg tgtaaattgt attcttaaca ttttgtattt tgtaggattg atcttatttt   2190

 gagacaaggg ttgtaaaatg tatttgctct cagaattcat ccccttctta gtattaggtc   2250

 attcttcatc tgtataattt ttattaactt tgagattctt atacagaaaa tagttgcaag   2310

 ggtaaggtaa ttaactttag atcccttcat ttctaaagca attattgagt gcttaaaatt   2370

 taaggttgtt ttagagtgga gtttgtgagt aaaagaggag cccagggaga cagattgcaa   2430

 gtagtaggtt gcaatctttt agattcagct tgtaataatc tttgagccac accaaaagga   2490

 atgccaaggg ctctctaaat ttagccagta ggaagctact gctctcctgg caaggattaa   2550

 ttggcacatt ctgttaagat atccctcatg acagttgccc tttcaaagca ggaggaagaa   2610

 aaggaagaaa gaaaaactgt ttcatcattt ctgttagggt aggaaatgaa tcatagggta   2670

 aaatggatga atagatagaa gtctctcatt taaaaagtgt cttttgcaat cttgatgtaa   2730

 tgcacttttt ataaggactt gagatctcaa ataaaaattc tgtaaagaat ttcca        2785




      <210> 232
      <211> 884
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(564)

      <400> 232
 gggagctcag ggcaggtacc tgaactctga gagggcttca cagaggagat gaccgaaacg     60

 taagtcctaa atgacaaata tagatgctcc agctggacca gagagtggaa ggcacgccag    120

 gcagaaggcg cacgtgagtt caagggcctg gagcatcctg tctcagagcg ttattttggt    180

 ctg  atg tcc aca cga agc ctc cag tct gtg gtg gtg ccc aga tgc cgg     228
      Met Ser Thr Arg Ser Leu Gln Ser Val Val Val Pro Arg Cys Arg
        1               5                  10                  15

 ggg acg gca gag gca ctt cag atc acg gtg ggc cac atc ctg gga gac      276
 Gly Thr Ala Glu Ala Leu Gln Ile Thr Val Gly His Ile Leu Gly Asp
                  20                  25                  30

 gct ggc agc ccc tat ctc aca gga ctt atc tct agt gtc ctg cgg gcc      324
 Ala Gly Ser Pro Tyr Leu Thr Gly Leu Ile Ser Ser Val Leu Arg Ala
              35                  40                  45

 agg cgc cct gac tcc tat ctg cag cgc ttc cgc agc ctg cag cag agc      372
 Arg Arg Pro Asp Ser Tyr Leu Gln Arg Phe Arg Ser Leu Gln Gln Ser
          50                  55                  60

 ttc ctg tgc tgc gcc ttt gtc atc gcc ctg ggg ggc ggc tgc ttc ctg      420
 Phe Leu Cys Cys Ala Phe Val Ile Ala Leu Gly Gly Gly Cys Phe Leu
      65                  70                  75

 ctg act gcg ctg tac ctg gag aga gac gag acc cgg gcc tgg cag cct      468
 Leu Thr Ala Leu Tyr Leu Glu Arg Asp Glu Thr Arg Ala Trp Gln Pro
  80                  85                  90                  95

 gtc aca ggg acc cca gac agc aat gat gtg gac agc aat gac ctg gag      516
 Val Thr Gly Thr Pro Asp Ser Asn Asp Val Asp Ser Asn Asp Leu Glu
                 100                 105                 110

 aga caa ggc ctg ctt tcg ggc gct ggc gcc tct aca gag gag ccc tga      564
 Arg Gln Gly Leu Leu Ser Gly Ala Gly Ala Ser Thr Glu Glu Pro 
             115                 120                 125

 ggtccctgcc tgcactcgtc ctgcctgcaa gcctcccgtt ggtccccaca gcagcagtgc    624

 ctcggttcct ctttggctgt cctcggggac tccggctgag gcacatctgc cacttttgaa    684

 ttcccggctg gagagctggc aggaccctgt ggctgggctg ggaatggagc tgtcagcact    744

 ctgcgtggga ggcctgggcc tgtgcctgca tcccgctcaa ggctgcccca gcctggggtc    804

 cccagcctgg ctgctgctgg gccctgaata aagagaggcc agtacaaagc ccatggattt    864

 tgggcctgta aaaaaaaaaa                                                884




      <210> 233
      <211> 3318
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (220)..(810)

      <400> 233
 cttatataga gtaaaataag ggtgagtgac cgagaggttg atgcatagct agatcaccag     60

 tttaaatgcc ttcccacaca cccctttcct cctgttccct ccacctacag gttgtagatg    120

 agcatgagag tgtggagcag agttggcgag tgcaagtcga gcccatcaac ctggacagct    180

 gtctccgtgc tttcaccagt gaggaagagc taggggaag   atg aga tat act act     234
                                              Met Arg Tyr Thr Thr
                                                1               5

 gtt cca agt gta aga ccc act gct tta gca aca aag aag ctg gat ctc      282
 Val Pro Ser Val Arg Pro Thr Ala Leu Ala Thr Lys Lys Leu Asp Leu
                  10                  15                  20

 tgg agg ctt cca ccc ttc ctg att att cac ctt aag cga ttt caa ttt      330
 Trp Arg Leu Pro Pro Phe Leu Ile Ile His Leu Lys Arg Phe Gln Phe
              25                  30                  35

 gta aat gat cag tgg ata aaa tca cag aaa att gtc aaa ttt cct cgg      378
 Val Asn Asp Gln Trp Ile Lys Ser Gln Lys Ile Val Lys Phe Pro Arg
          40                  45                  50

 gaa agt ttt gat ccg agt gct ttt ttg gta cca cga gac ccg gct ctc      426
 Glu Ser Phe Asp Pro Ser Ala Phe Leu Val Pro Arg Asp Pro Ala Leu
      55                  60                  65

 tgc cag cat caa cca ctc aca ccc cag ggg gat gag ctc tcc aag ccc      474
 Cys Gln His Gln Pro Leu Thr Pro Gln Gly Asp Glu Leu Ser Lys Pro
  70                  75                  80                  85

 agg att ctg gca aga gag gtg aag aaa gtg gat gtg cag agt ttg gct      522
 Arg Ile Leu Ala Arg Glu Val Lys Lys Val Asp Val Gln Ser Leu Ala
                  90                  95                 100

 ggg gaa gag gac atg ctc ctg agc aaa agc cca tcc tca ctc agc gct      570
 Gly Glu Glu Asp Met Leu Leu Ser Lys Ser Pro Ser Ser Leu Ser Ala
             105                 110                 115

 aac atc agc agc agc cca aaa ggt tct cct tct tca tca aga aaa agt      618
 Asn Ile Ser Ser Ser Pro Lys Gly Ser Pro Ser Ser Ser Arg Lys Ser
         120                 125                 130

 gga acc agc tgt ccc tcc agc aaa aac agc agc cct aat agc tgc cca      666
 Gly Thr Ser Cys Pro Ser Ser Lys Asn Ser Ser Pro Asn Ser Cys Pro
     135                 140                 145

 cgg act ttg ggg agg agc aaa ggg agg ctc cgg ctg ccc cag att ggc      714
 Arg Thr Leu Gly Arg Ser Lys Gly Arg Leu Arg Leu Pro Gln Ile Gly
 150                 155                 160                 165

 agc aaa aat aaa ctg tca agt agt aag aag aac ttg gat gcc agc aaa      762
 Ser Lys Asn Lys Leu Ser Ser Ser Lys Lys Asn Leu Asp Ala Ser Lys
                 170                 175                 180

 gag aat ggg gct ggg cag atc tgt gag ctg gct gat gcc ttg agc tga      810
 Glu Asn Gly Ala Gly Gln Ile Cys Glu Leu Ala Asp Ala Leu Ser 
             185                 190                 195

 gggcatatgc gggggggcag ccaaccagag ctggtcactc ctcaggacca cgaggtagct    870

 ttgggcaatg gattccttta tgagcatgaa gcatatggca atggctacag caatggtcag    930

 cttggaaacc acagtgaaga agacagcact gatgaccaaa gagaagacac tcatattaag    990

 cctatttata atctatatgc aatttcatgc cattcaggaa ttctgagtgg gggccattac   1050

 gtcacttatg ccaaaaaccc aaactgcaag tggtactgct acaatggcag catctgtgag   1110

 gaacatcacc ctgatgaaat tgacaccgac tctgcctaca ttcttttcta tgagcagcag   1170

 aggatagact acgcacaatt tctgccaaag attgatggca aaaagatggc agacacaagc   1230

 agtatggatg aagactttga gtctgattac gaaaagtact gtgtgttaca gtaaagctac   1290

 cactctggct gctagatagc ttggtgggga gggagatgac tccttgtagc tgatacttgg   1350

 caaaagtgtc actgagaggc aagctaaatg tagttatttt atcctgttag aatacaaatt   1410

 ctaattaaaa tagttaactt taagagtagt agtaatttta ttttgaagtc tcatgcaagt   1470

 tgtctgatag agaactttca ggcagatccc accattagcc tgtaaacaaa aagtttggca   1530

 ccagccacct gggaccaaat aagaattcaa ttgtgcttgt ccagatatga acaaatatgt   1590

 agtgagtata gagtttatca ataatcataa caaatattaa agatttcctt ggagtcaaag   1650

 taaaaaacaa aaaattgtaa tgttgtctag ggatgacatg atatgctacc tcctttttcc   1710

 tgaagtttta ttccattctg ttgacaagat ggagaaagca agatcatgaa ggtgtgcaaa   1770

 tgattcttac ggcatgggcg aggatttttc aatttatttt ttaaagtttc catacccttt   1830

 ctttgtcttt cttgcttttt gtttttgccg ttgtgtttat gtttgagata caaccagtca   1890

 ttggtggcag gggcatagag tggtcagtct gaaagggagg ctctcttaag agctatgtgc   1950

 cttccaccca gagggagacc cagtagaaag aaaaacatcc tgggaaatcc agctaccatg   2010

 gccctcccag tggaggcatc ttacatttag gatacttcag gtatcctcag aaatgtattc   2070

 tgcacccccc ggccccgccc atgctgaggg aaggggagca gttgccaata tttgcaccat   2130

 cttcacatgc acatgttgca acaagagctt ctgggaaggt aagcggcatc ggagctagat   2190

 cacgtttcac aattagtggt ggttcttttc catgtttgtt ttgcacttta aaaaagagag   2250

 aacacatgca aatgaacttg cttgtgtgta tttgatggct ccaagggcta taaattacaa   2310

 acaaaacaca tcccagacat taggagttca taagtatatt taatgaaatt ggtggtttta   2370

 ggaagtcaac tttagttttg ctttgtttgc atgtccacta atttttttat tttgatatta   2430

 gtctttttta aaaaatttta cagtagtcat tgaaagttat gtttctttgt ttacttcatt   2490

 ttttcctcta aatattcaag actgggacaa aagtataaat attatttatt tcaggtagaa   2550

 tttttttggt gtagtttttt aatatatact tgaaggaaat gtttcacctt atttttggtc   2610

 tttgtttatt catttagacc ctgcaagttg attctcatta attgtcagat tccactacac   2670

 tttcttcctc ataggtagta attaccagtg taactaagca tttgtgttct gatatctgag   2730

 gccagtaact attaatatct agttctcaga gcatttggaa aggttatctt aaatggctac   2790

 ctaaattgaa atccttttca gaaaaaatat aattgcaaat aggtaggagt ggcctaaatt   2850

 atctaatgta ataaagtcag acaaaatgca tactttatag ttcaagattt tcggtatata   2910

 aaatctgtcc tttcctacct ggacatgtcc cattaaaaag tggaagattt taaataattt   2970

 ctttacagat gttttattta agcaggtagc acaatctact aatgttgttt gatctgtgtt   3030

 tgttatactg gttgtaatta atttttttaa ttcatgaact agcggaaaat ttattaaatt   3090

 aactattaac cacattcacc ttgtaaatga ctgtataaaa cttgttgaca atgcactgac   3150

 tttagaaaga tgttaatgtg cataaataga gtgtaaataa aatagtgttg atgtactgaa   3210

 atatgaactg tataaaaagt attagtaatt gtatatgggg tgtacctgtt tatctgtaac   3270

 tgttatccaa acaaattaaa tactgtggat gcctttaaaa aaaaaaaa                3318




      <210> 234
      <211> 595
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (300)..(548)

      <400> 234
 gcggtgcaat tcatttggtt gaggaatggc gggagaaaga actggaaagg tagattaggt     60

 tggtggtggt gagggctgca ctgggaataa aatccagggg cctcaccatc cagcaggctc    120

 cccatggtcc caccctactg tgtgtcccag cccctgcctg ctggagactc ttactggctt    180

 cttctcctcc gcaggcgaag cccgttctcc cctcagggcc tttgcactta tcccttagcc    240

 tggaagggtc tttctctggc tctgcctggc aggatccttc tcgttctcat ctcagccaa     299                                                                 
 atg ctg ggt tcc cag aca ggc ccc ctc ccg tct ccc tat ccg gag cac      347
 Met Leu Gly Ser Gln Thr Gly Pro Leu Pro Ser Pro Tyr Pro Glu His
   1               5                  10                  15

 cct ccc ctt tct ccc acc acg ctc tgc ctt ggt gtc ctc tgt gat ttt      395
 Pro Pro Leu Ser Pro Thr Thr Leu Cys Leu Gly Val Leu Cys Asp Phe
              20                  25                  30

 ctt caa agc act ctc gcc atg tgg aga tgt tat ctt tgc cta ctt gct      443
 Leu Gln Ser Thr Leu Ala Met Trp Arg Cys Tyr Leu Cys Leu Leu Ala
          35                  40                  45

 ttc tgt cct ttg gta tct ctc cca tcc cac tgg aga gtt gac ttc cct      491
 Phe Cys Pro Leu Val Ser Leu Pro Ser His Trp Arg Val Asp Phe Pro
      50                  55                  60

 cct gcg ggc ccc cac ctc cgc ttc tcc ttg ctc aca tgc tgc ctg gct      539
 Pro Ala Gly Pro His Leu Arg Phe Ser Leu Leu Thr Cys Cys Leu Ala
  65                  70                  75                  80

 ctt ggc tga cgctcag aaactgatgt gggctcaccc tcgcaggccg ggcactgcgc      595
 Leu Gly 






      <210> 235
      <211> 1637
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (806)..(1342)

      <400> 235
 tcattcctct ggtatctctg tcccagaggg acactgacct gctgtctgca ggaacattcc     60

 tgtataaggt gtcttatgac ccctgttggg gggtctcatg tagtcagaag gcatgggatc    120

 tgggacccat ttaacaaagc actctggctg ccccttggca gagaaggtgt gctgcactgg    180

 ggggtgtgct tgttctttct cacaacctaa ttcccagctc tccaaatcca tatcaagtac    240

 tatcttcacc ctgaagtctt tgcttttacc atcttcccct ccagtgctaa actgtctcct    300

 tcctaaccct cctaaaggat tgacagatag tgatattcca tcactgaggc cagaggatcc    360

 actatttgtc aaagggctaa ggaaggagct ggtgagaggg acatcggtgt cattgcgatg    420

 ttcattaatg cttgttagtc tagggctgac aacagaagat gccattccca aactatagct    480

 ctcccaggct ccccaagaac atcgcccctc tggctggagc gcaattggtg attggctact    540

 taacccgtcc gtcctttccc gcccaggggt ccaatccaat ccagcccggc tccgctcgga    600

 gacagttcgc cgagtgggcg gtgtctatga cgttttctga cgtgttacgt cacggtgggc    660

 ggaagtcgcg gccgctgttt tgaaatcggg ccgcgggggg tctctcaagc tggttccaac    720

 gctgaggccc cacagcctcc caattccggg cagacccctg acacctgctg tctggcccct    780

 tccggcctga agctgcagcc gcgcc  atg tcc acc cct ccg ttg gcc gcg tcg     832
                              Met Ser Thr Pro Pro Leu Ala Ala Ser
                                1               5

 ggg atg gcg ccc ggg ccc ttc gcc ggg ccc cag gct cag cag gcc gcc      880
 Gly Met Ala Pro Gly Pro Phe Ala Gly Pro Gln Ala Gln Gln Ala Ala
  10                  15                  20                  25

 cgg gaa gtc aac acg gcg tcg ctg tgc cgc atc ggg cag gag aca gtg      928
 Arg Glu Val Asn Thr Ala Ser Leu Cys Arg Ile Gly Gln Glu Thr Val
                  30                  35                  40

 cag gac atc gtg tac cgc acc atg gag atc ttc cag ctc ctg agg aac      976
 Gln Asp Ile Val Tyr Arg Thr Met Glu Ile Phe Gln Leu Leu Arg Asn
              45                  50                  55

 atg cag ctg cca aat ggt gtc act tac cac act gga aca tat caa gac     1024
 Met Gln Leu Pro Asn Gly Val Thr Tyr His Thr Gly Thr Tyr Gln Asp
          60                  65                  70

 cgg tta aca aag cta cag gat aat ctt cgc caa ctt tca gtt ctc ttc     1072
 Arg Leu Thr Lys Leu Gln Asp Asn Leu Arg Gln Leu Ser Val Leu Phe
      75                  80                  85

 agg aag ctg aga ttg gta tat gac aaa tgc aat gaa aac tgt ggt ggg     1120
 Arg Lys Leu Arg Leu Val Tyr Asp Lys Cys Asn Glu Asn Cys Gly Gly
  90                  95                 100                 105

 atg gat ccc att cca gtc gag caa ctt att cca tat gtg gaa gaa gat     1168
 Met Asp Pro Ile Pro Val Glu Gln Leu Ile Pro Tyr Val Glu Glu Asp
                 110                 115                 120

 ggc tca aag aat gat gat cgg gct ggc cca cct cgt ttt gct agt gaa     1216
 Gly Ser Lys Asn Asp Asp Arg Ala Gly Pro Pro Arg Phe Ala Ser Glu
             125                 130                 135

 gag agg cga gaa att gct gaa gta aat aaa aaa ctc aaa cag aag aat     1264
 Glu Arg Arg Glu Ile Ala Glu Val Asn Lys Lys Leu Lys Gln Lys Asn
         140                 145                 150

 caa cag ctg aaa caa att atg gat caa tta cga aat ctc atc tgg gat     1312
 Gln Gln Leu Lys Gln Ile Met Asp Gln Leu Arg Asn Leu Ile Trp Asp
     155                 160                 165

 ata aat gcc atg ttg gca atg agg aac taa g ctgatattta aatttcctgc     1363
 Ile Asn Ala Met Leu Ala Met Arg Asn 
 170                 175

 tttacacatg ttataccatt gttttttccc tcaagtattt tttccctgtg aagaagatta   1423

 tttatctgct tttattttag tcactaaaac taaagttttt atttttacat tgtgattttt   1483

 acattaaaat attaactttt tttaatgcta ttttatgaaa gattattgta ataaactttg   1543

 atggggtttg tattttggtt aatcttcatg aattgaataa ttgttttttt aaagcaaaat   1603

 aaagtttttt aaataaatgt taaaaaaaaa aaaa                               1637




      <210> 236
      <211> 1820
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(1790)

      <400> 236
 acccccacac c atg gcg agc gtg gtg gtg aag acg atc tgg cag tcc aaa      50
              Met Ala Ser Val Val Val Lys Thr Ile Trp Gln Ser Lys
                1               5                  10

 gag atc cat gag gcc ggg gac acc ccc acg ggg gtg gag agc tgc tcc       98
 Glu Ile His Glu Ala Gly Asp Thr Pro Thr Gly Val Glu Ser Cys Ser
      15                  20                  25

 cag cta gtc cca gag gct ccc cgg agg gtg acc agc cgg gcc aag ggg      146
 Gln Leu Val Pro Glu Ala Pro Arg Arg Val Thr Ser Arg Ala Lys Gly
  30                  35                  40                  45

 atc ccg aag aaa aag aag gcc gtg tcg ttc cac ggg gtg gag ccc cag      194
 Ile Pro Lys Lys Lys Lys Ala Val Ser Phe His Gly Val Glu Pro Gln
                  50                  55                  60

 atg tcc cat cag ccc atg cac tgg tgc ctg aac ctc aaa cgg tcc tcg      242
 Met Ser His Gln Pro Met His Trp Cys Leu Asn Leu Lys Arg Ser Ser
              65                  70                  75

 gcc tgc acc aac gtg tca ctg ctc aac ctg gcc gcc atg gag ccc act      290
 Ala Cys Thr Asn Val Ser Leu Leu Asn Leu Ala Ala Met Glu Pro Thr
          80                  85                  90

 gac tcc acg ggg aca gac tcc aca gtg gaa gac ctc agc ggc caa ctc      338
 Asp Ser Thr Gly Thr Asp Ser Thr Val Glu Asp Leu Ser Gly Gln Leu
      95                 100                 105

 aca ctg gct ggg ccc cct gcc tcc cct acc cta ccc tgg gat ccg gat      386
 Thr Leu Ala Gly Pro Pro Ala Ser Pro Thr Leu Pro Trp Asp Pro Asp
 110                 115                 120                 125

 gac gca gac atc acg gaa atc ctg agt ggg gtc aac agt gga ttg gtc      434
 Asp Ala Asp Ile Thr Glu Ile Leu Ser Gly Val Asn Ser Gly Leu Val
                 130                 135                 140

 cgc gcc aaa gac tcc atc acc agc ttg aag gaa aag acc aac cgg gtt      482
 Arg Ala Lys Asp Ser Ile Thr Ser Leu Lys Glu Lys Thr Asn Arg Val
             145                 150                 155

 aac cag cac gtg cag tct ctg cag agc gag tgt tct gtg ctg agc gag      530
 Asn Gln His Val Gln Ser Leu Gln Ser Glu Cys Ser Val Leu Ser Glu
         160                 165                 170

 aat ctg gag aga agg cgg caa gag gca gaa gag ttg gag ggg tac tgc      578
 Asn Leu Glu Arg Arg Arg Gln Glu Ala Glu Glu Leu Glu Gly Tyr Cys
     175                 180                 185

 att caa ctc aag gag aac tgc tgg aag gtg acc cgg tct gtg gaa gat      626
 Ile Gln Leu Lys Glu Asn Cys Trp Lys Val Thr Arg Ser Val Glu Asp
 190                 195                 200                 205

 gct gaa atc aaa acc aac gtc ttg aag cag aat tct gcc ctg ctg gag      674
 Ala Glu Ile Lys Thr Asn Val Leu Lys Gln Asn Ser Ala Leu Leu Glu
                 210                 215                 220

 gag aag ctg cgc tac ctc cag cag cag ctg cag gat gag acg ccg cga      722
 Glu Lys Leu Arg Tyr Leu Gln Gln Gln Leu Gln Asp Glu Thr Pro Arg
             225                 230                 235

 cgg cag gag gcc gag ctg cag gag ccg gag gag aag cag gag ccg gag      770
 Arg Gln Glu Ala Glu Leu Gln Glu Pro Glu Glu Lys Gln Glu Pro Glu
         240                 245                 250

 gag aag cag gag ccg gag gag aag cag aag ccg gag gct ggc ctc tcc      818
 Glu Lys Gln Glu Pro Glu Glu Lys Gln Lys Pro Glu Ala Gly Leu Ser
     255                 260                 265

 tgg aac agc ctg ggc ccc gcc gcc acg tcc cag ggc tgc ccc ggc ccg      866
 Trp Asn Ser Leu Gly Pro Ala Ala Thr Ser Gln Gly Cys Pro Gly Pro
 270                 275                 280                 285

 cca ggg agt ccc gac aaa ccc tcg cgg cca cac ggc ctg gtc ccc gca      914
 Pro Gly Ser Pro Asp Lys Pro Ser Arg Pro His Gly Leu Val Pro Ala
                 290                 295                 300

 ggc tgg gga atg ggg cct cgg gct ggc gag ggc ccc tac gtg agc gag      962
 Gly Trp Gly Met Gly Pro Arg Ala Gly Glu Gly Pro Tyr Val Ser Glu
             305                 310                 315

 cag gaa ttg cag aag ctg ttc acc ggc atc gaa gag ctg agg aga gag     1010
 Gln Glu Leu Gln Lys Leu Phe Thr Gly Ile Glu Glu Leu Arg Arg Glu
         320                 325                 330

 gtg tcc tca ctg acc gcc cgg tgg cat cag gag gag ggg gcg gtg cag     1058
 Val Ser Ser Leu Thr Ala Arg Trp His Gln Glu Glu Gly Ala Val Gln
     335                 340                 345

 gaa gcc ctg cgg ctg ctc ggg ggc ctg ggc ggc agg gtc gac ggc ttc     1106
 Glu Ala Leu Arg Leu Leu Gly Gly Leu Gly Gly Arg Val Asp Gly Phe
 350                 355                 360                 365

 cta ggc cag tgg gag cgg gca cag cgc gaa cag gca cag acg gcg cgg     1154
 Leu Gly Gln Trp Glu Arg Ala Gln Arg Glu Gln Ala Gln Thr Ala Arg
                 370                 375                 380

 gac ttg cag gag ctg cga ggt cgg gcg gat gag ctg tgc acc atg gtg     1202
 Asp Leu Gln Glu Leu Arg Gly Arg Ala Asp Glu Leu Cys Thr Met Val
             385                 390                 395

 gag cgg tca gca gtg tct gtg gct tca ctg agg agc gaa ctg gag ggg     1250
 Glu Arg Ser Ala Val Ser Val Ala Ser Leu Arg Ser Glu Leu Glu Gly
         400                 405                 410

 ctg ggc cca ctg aaa ccc att ctg gag gag ttc ggg cgg caa ttt cag     1298
 Leu Gly Pro Leu Lys Pro Ile Leu Glu Glu Phe Gly Arg Gln Phe Gln
     415                 420                 425

 aac tct cga aga ggg cct gac ctc tcc atg aac ctg gat cgg tcc cac     1346
 Asn Ser Arg Arg Gly Pro Asp Leu Ser Met Asn Leu Asp Arg Ser His
 430                 435                 440                 445

 caa ggc aac tgt gcc cgc tgt gcc agc cag ggg tcg cag ttg tct acg     1394
 Gln Gly Asn Cys Ala Arg Cys Ala Ser Gln Gly Ser Gln Leu Ser Thr
                 450                 455                 460

 gag tcc ctg cag cag ctg ctg gac cga gca ctg acc tca cta gtg gac     1442
 Glu Ser Leu Gln Gln Leu Leu Asp Arg Ala Leu Thr Ser Leu Val Asp
             465                 470                 475

 gag gtg aag cag agg ggc ctg act cct gcc tgt ccc agc tgt cag agg     1490
 Glu Val Lys Gln Arg Gly Leu Thr Pro Ala Cys Pro Ser Cys Gln Arg
         480                 485                 490

 cta cac aag aag att ctg gag ctg gag cgc cag gcc tta gcc aaa cac     1538
 Leu His Lys Lys Ile Leu Glu Leu Glu Arg Gln Ala Leu Ala Lys His
     495                 500                 505

 gtc agg gca gag gcc ctg agc tcc acc ctt cgg ctg gcc caa gac gag     1586
 Val Arg Ala Glu Ala Leu Ser Ser Thr Leu Arg Leu Ala Gln Asp Glu
 510                 515                 520                 525

 gcc ctg cgg gcc aag aac cta ctg ctg aca gac aag atg aag cca gag     1634
 Ala Leu Arg Ala Lys Asn Leu Leu Leu Thr Asp Lys Met Lys Pro Glu
                 530                 535                 540

 gag aag atg gcc act ctg gac cat cta cac ttg aag atg tgc tcc ctc     1682
 Glu Lys Met Ala Thr Leu Asp His Leu His Leu Lys Met Cys Ser Leu
             545                 550                 555

 cac gat cat ctc agc aac ctg cca ctt gag ggg tcc acg gga aca atg     1730
 His Asp His Leu Ser Asn Leu Pro Leu Glu Gly Ser Thr Gly Thr Met
         560                 565                 570

 ggg gga ggc agc agt gca gga acc ccc cca aaa cag ggg ggc tca gcc     1778
 Gly Gly Gly Ser Ser Ala Gly Thr Pro Pro Lys Gln Gly Gly Ser Ala
     575                 580                 585

 cct gaa caa taa atggcctctc atgctagcaa aaaaaaaaaa                    1820
 Pro Glu Gln 
 590





      <210> 237
      <211> 1697
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (15)..(1364)

      <400> 237
 aaagaacctc gaca  atg gac aga gtt tat gaa att cct gag gag cca aat      50
                  Met Asp Arg Val Tyr Glu Ile Pro Glu Glu Pro Asn
                    1               5                  10

 gtg gat ccg gtt tca tct ctg gag gaa gat gtc atc cgt gga gcc aac       98
 Val Asp Pro Val Ser Ser Leu Glu Glu Asp Val Ile Arg Gly Ala Asn
          15                  20                  25

 ccc cga ttt act ttt cca ttt agc atc ctt ttc tcc acc ttt ttg tac      146
 Pro Arg Phe Thr Phe Pro Phe Ser Ile Leu Phe Ser Thr Phe Leu Tyr
      30                  35                  40

 tgt ggg gag gct gca tct gct ttg tac atg gtt aga atc tat cga aag      194
 Cys Gly Glu Ala Ala Ser Ala Leu Tyr Met Val Arg Ile Tyr Arg Lys
  45                  50                  55                  60

 aat agt gaa act tac tgg atg aca tac acc ttt tct ttc ttt atg ttt      242
 Asn Ser Glu Thr Tyr Trp Met Thr Tyr Thr Phe Ser Phe Phe Met Phe
                  65                  70                  75

 tca tcc att atg gtc cag ttg acc ctc att ttt gtc cac aga gat cta      290
 Ser Ser Ile Met Val Gln Leu Thr Leu Ile Phe Val His Arg Asp Leu
              80                  85                  90

 gcc aaa gat aaa ccg cta tca tta ttt atg cat cta atc ctc ttg gga      338
 Ala Lys Asp Lys Pro Leu Ser Leu Phe Met His Leu Ile Leu Leu Gly
          95                 100                 105

 cct gtt atc aga tgt ttg gag gcc atg att aag tac ctc aca ctg tgg      386
 Pro Val Ile Arg Cys Leu Glu Ala Met Ile Lys Tyr Leu Thr Leu Trp
     110                 115                 120

 aag aaa gag gag cag gag gag ccc tat gtc agc ctc acc cga aag aag      434
 Lys Lys Glu Glu Gln Glu Glu Pro Tyr Val Ser Leu Thr Arg Lys Lys
 125                 130                 135                 140

 atg cta ata gat ggc gag gag gtg ctg ata gaa tgg gag gtg ggc cac      482
 Met Leu Ile Asp Gly Glu Glu Val Leu Ile Glu Trp Glu Val Gly His
                 145                 150                 155

 tcc atc cgg acc ctg gct atg cac cgc aat gcc tac aaa cgt atg tca      530
 Ser Ile Arg Thr Leu Ala Met His Arg Asn Ala Tyr Lys Arg Met Ser
             160                 165                 170

 cag atc caa gcc ttc ctg ggc tca gtg ccc cag ctg acc tat cag ctc      578
 Gln Ile Gln Ala Phe Leu Gly Ser Val Pro Gln Leu Thr Tyr Gln Leu
         175                 180                 185

 tat gtg agc ctg atc tct gca gag gtt ccc ctg ggt aga gtt gtg cta      626
 Tyr Val Ser Leu Ile Ser Ala Glu Val Pro Leu Gly Arg Val Val Leu
     190                 195                 200

 atg gta ttt tcc ctg gta tct gtc acc tat ggg gcc acc ctt tgc aat      674
 Met Val Phe Ser Leu Val Ser Val Thr Tyr Gly Ala Thr Leu Cys Asn
 205                 210                 215                 220

 atg ttg gct atc cag atc aag tac gat gac tac aag att cgc ctt ggg      722
 Met Leu Ala Ile Gln Ile Lys Tyr Asp Asp Tyr Lys Ile Arg Leu Gly
                 225                 230                 235

 cca cta gaa gtc ctc tgc atc acc atc tgg cgg aca ttg gag atc act      770
 Pro Leu Glu Val Leu Cys Ile Thr Ile Trp Arg Thr Leu Glu Ile Thr
             240                 245                 250

 tcc cgc ctc ctg att ctg gtg ctc ttc tca gcc act ttg aaa ttg aag      818
 Ser Arg Leu Leu Ile Leu Val Leu Phe Ser Ala Thr Leu Lys Leu Lys
         255                 260                 265

 gct gtg ccc ttc cta gtg ctc aac ttc ctg atc atc ctc ttt gag ccc      866
 Ala Val Pro Phe Leu Val Leu Asn Phe Leu Ile Ile Leu Phe Glu Pro
     270                 275                 280

 tgg att aag ttc tgg aga agt ggt gcc cag atg ccc aat aac att gag      914
 Trp Ile Lys Phe Trp Arg Ser Gly Ala Gln Met Pro Asn Asn Ile Glu
 285                 290                 295                 300

 aaa aac ttc agc cgg gtc ggc act ctg gtg gtc ctg att tca gtc acc      962
 Lys Asn Phe Ser Arg Val Gly Thr Leu Val Val Leu Ile Ser Val Thr
                 305                 310                 315

 atc ctc tat gct ggc atc aac ttc tct tgc tgg tca gct ttg cag ttg     1010
 Ile Leu Tyr Ala Gly Ile Asn Phe Ser Cys Trp Ser Ala Leu Gln Leu
             320                 325                 330

 agg ttg gca gac aga gat ctc gtc gac aaa ggg cag aac tgg gga cat     1058
 Arg Leu Ala Asp Arg Asp Leu Val Asp Lys Gly Gln Asn Trp Gly His
         335                 340                 345

 atg ggc ctg cac tat agt gtg agg ttg gta gag aat gtg atc atg gtc     1106
 Met Gly Leu His Tyr Ser Val Arg Leu Val Glu Asn Val Ile Met Val
     350                 355                 360

 ttg gtt ttt aag ttc ttt gga gtg aaa gtg tta ctg aat tac tgt cat     1154
 Leu Val Phe Lys Phe Phe Gly Val Lys Val Leu Leu Asn Tyr Cys His
 365                 370                 375                 380

 tcc ttg att gcc ttg cag ctc att att gct tat ctg att tcc att ggc     1202
 Ser Leu Ile Ala Leu Gln Leu Ile Ile Ala Tyr Leu Ile Ser Ile Gly
                 385                 390                 395

 ttc atg ctc ctt ttc ttc cag tac ttg cat cca ttg cgc tca ctc ttc     1250
 Phe Met Leu Leu Phe Phe Gln Tyr Leu His Pro Leu Arg Ser Leu Phe
             400                 405                 410

 acc cat aat gta gta gac tac ctc cat tgt gtc tgc tgt cac cag cac     1298
 Thr His Asn Val Val Asp Tyr Leu His Cys Val Cys Cys His Gln His
         415                 420                 425

 cct cgg acc agg gtt gag aac tca gag cca ccc ttt gag act gaa gca     1346
 Pro Arg Thr Arg Val Glu Asn Ser Glu Pro Pro Phe Glu Thr Glu Ala
     430                 435                 440

 agg caa agt gtt gtc tga ttctat tttctgggta ttttaggaag agttgggagt     1400
 Arg Gln Ser Val Val 
 445

 tgccaagagt aaccatgaaa ttgaacgaaa ggatgaggtt catgggtgag atacccatca   1460

 gtacattttc ttgacttttc tgttaagcct atcagaagaa agagcaactc ccaaataggt   1520

 tttattttct taagagttac cactatgttt ggaaacaggg ggtatcgact atatagttga   1580

 aagggtcaga aataccattc acaccctgtc ttacccaagt caattggaat aaatggtatt   1640

 tcaaacactt gagggtctct aaagtgacct ctaagctctg ttcatttgtc tgagtgg      1697




      <210> 238
      <211> 3546
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3447)

      <400> 238
  atg ccc ttg ttc aag aac acc agt gtc agc tct ctg tac tct ggt tgc      48
  Met Pro Leu Phe Lys Asn Thr Ser Val Ser Ser Leu Tyr Ser Gly Cys
    1               5                  10                  15

 aga ctg acc ttg ctc agg cct gag aag gat ggg gca gcc acc aga gtg       96
 Arg Leu Thr Leu Leu Arg Pro Glu Lys Asp Gly Ala Ala Thr Arg Val
              20                  25                  30

 gat gct gtc tgc acc cat cgt cct gac ccc aaa agc cct gga ctg gac      144
 Asp Ala Val Cys Thr His Arg Pro Asp Pro Lys Ser Pro Gly Leu Asp
          35                  40                  45

 aga gag cgg ctg tac tgg aag ctg agc cag ctg acc cac ggc atc act      192
 Arg Glu Arg Leu Tyr Trp Lys Leu Ser Gln Leu Thr His Gly Ile Thr
      50                  55                  60

 gag ctg ggc ccc tac acc ctg gac agg cac agt ctc tat gtc aat ggt      240
 Glu Leu Gly Pro Tyr Thr Leu Asp Arg His Ser Leu Tyr Val Asn Gly
  65                  70                  75                  80

 ttc acc cat cag agc tct atg acg acc acc aga act cct gat acc tcc      288
 Phe Thr His Gln Ser Ser Met Thr Thr Thr Arg Thr Pro Asp Thr Ser
                  85                  90                  95

 aca atg cac ctg gca acc tcg aga act cca gcc tcc ctg tct gga cct      336
 Thr Met His Leu Ala Thr Ser Arg Thr Pro Ala Ser Leu Ser Gly Pro
             100                 105                 110

 acg acc gcc agc cct ctc ctg gtg cta ttc aca att aac ttc acc atc      384
 Thr Thr Ala Ser Pro Leu Leu Val Leu Phe Thr Ile Asn Phe Thr Ile
         115                 120                 125

 act aac ctg cgg tat gag gag aac atg cat cac cct ggc tct aga aag      432
 Thr Asn Leu Arg Tyr Glu Glu Asn Met His His Pro Gly Ser Arg Lys
     130                 135                 140

 ttt aac acc acg gag aga gtc ctt cag ggt ctg ctc agg cct gtg ttc      480
 Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Arg Pro Val Phe
 145                 150                 155                 160

 aag aac acc agt gtt ggc cct ctg tac tct ggc tgc aga ctg acc ttg      528
 Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu
                 165                 170                 175

 ctc agg ccc aag aag gat ggg gca gcc acc aaa gtg gat gcc atc tgc      576
 Leu Arg Pro Lys Lys Asp Gly Ala Ala Thr Lys Val Asp Ala Ile Cys
             180                 185                 190

 acc tac cgc cct gat ccc aaa agc cct gga ctg gac aga gag cag cta      624
 Thr Tyr Arg Pro Asp Pro Lys Ser Pro Gly Leu Asp Arg Glu Gln Leu
         195                 200                 205

 tac tgg gag ctg agc cag cta acc cac agc atc act gag ctg ggc ccc      672
 Tyr Trp Glu Leu Ser Gln Leu Thr His Ser Ile Thr Glu Leu Gly Pro
     210                 215                 220

 tac acc ctg gac agg gac agt ctc tat gtc aat ggt ttc aca cag cgg      720
 Tyr Thr Leu Asp Arg Asp Ser Leu Tyr Val Asn Gly Phe Thr Gln Arg
 225                 230                 235                 240

 agc tct gtg ccc acc act agc att cct ggg acc ccc aca gtg gac ctg      768
 Ser Ser Val Pro Thr Thr Ser Ile Pro Gly Thr Pro Thr Val Asp Leu
                 245                 250                 255

 gga aca tct ggg act cca gtt tct aaa cct ggt ccc tcg gct gcc agc      816
 Gly Thr Ser Gly Thr Pro Val Ser Lys Pro Gly Pro Ser Ala Ala Ser
             260                 265                 270

 cct ctc ctg gtg cta ttc act ctc aac ttc acc atc acc aac ctg cgg      864
 Pro Leu Leu Val Leu Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Arg
         275                 280                 285

 tat gag gag aac atg cag cac cct ggc tcc agg aag ttc aac acc acg      912
 Tyr Glu Glu Asn Met Gln His Pro Gly Ser Arg Lys Phe Asn Thr Thr
     290                 295                 300

 gag agg gtc ctt cag ggc ctg ctc agg tcc ctg ttc aag agc acc agt      960
 Glu Arg Val Leu Gln Gly Leu Leu Arg Ser Leu Phe Lys Ser Thr Ser
 305                 310                 315                 320

 gtt ggc cct ctg tac tct ggc tgc aga ctg act ttg ctc agg cct gaa     1008
 Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu
                 325                 330                 335

 aag gat ggg aca gcc act gga gtg gat gcc atc tgc acc cac cac cct     1056
 Lys Asp Gly Thr Ala Thr Gly Val Asp Ala Ile Cys Thr His His Pro
             340                 345                 350

 gac ccc aaa agc cct agg ctg gac aga gag cag ctg tat tgg gag ctg     1104
 Asp Pro Lys Ser Pro Arg Leu Asp Arg Glu Gln Leu Tyr Trp Glu Leu
         355                 360                 365

 agc cag ctg acc cac aat atc act gag ctg ggc ccc tat gcc ctg gac     1152
 Ser Gln Leu Thr His Asn Ile Thr Glu Leu Gly Pro Tyr Ala Leu Asp
     370                 375                 380

 aac gac agc ctc ttt gtc aat ggt ttc act cat cgg agc tct gtg tcc     1200
 Asn Asp Ser Leu Phe Val Asn Gly Phe Thr His Arg Ser Ser Val Ser
 385                 390                 395                 400

 acc acc agc act cct ggg acc ccc aca gtg tat ctg gga gca tct aag     1248
 Thr Thr Ser Thr Pro Gly Thr Pro Thr Val Tyr Leu Gly Ala Ser Lys
                 405                 410                 415

 act cca gcc tcg ata ttt ggc cct tca gct gcc agc cat ctc ctg ata     1296
 Thr Pro Ala Ser Ile Phe Gly Pro Ser Ala Ala Ser His Leu Leu Ile
             420                 425                 430

 cta ttc acc ctc aac ttc acc atc act aac ctg cgg tat gag gag aac     1344
 Leu Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Arg Tyr Glu Glu Asn
         435                 440                 445

 atg tgg cct ggc tcc agg aag ttc aac act aca gag agg gtc ctt cag     1392
 Met Trp Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln
     450                 455                 460

 ggc ctg cta agg ccc ttg ttc aag aac acc agt gtt ggc cct ctg tac     1440
 Gly Leu Leu Arg Pro Leu Phe Lys Asn Thr Ser Val Gly Pro Leu Tyr
 465                 470                 475                 480

 tct ggc tcc agg ctg acc ttg ctc agg cca gag aaa gat ggg gaa gcc     1488
 Ser Gly Ser Arg Leu Thr Leu Leu Arg Pro Glu Lys Asp Gly Glu Ala
                 485                 490                 495

 acc gga gtg gat gcc atc tgc acc cac cgc cct gac ccc aca ggc cct     1536
 Thr Gly Val Asp Ala Ile Cys Thr His Arg Pro Asp Pro Thr Gly Pro
             500                 505                 510

 ggg ctg gac aga gag cag ctg tat ttg gag ctg agc cag ctg acc cac     1584
 Gly Leu Asp Arg Glu Gln Leu Tyr Leu Glu Leu Ser Gln Leu Thr His
         515                 520                 525

 agc atc act gag ctg ggc ccc tac aca ctg gac agg gac agt ctc tat     1632
 Ser Ile Thr Glu Leu Gly Pro Tyr Thr Leu Asp Arg Asp Ser Leu Tyr
     530                 535                 540

 gtc aat ggt ttc acc cat cgg agc tct gta ccc acc acc agc acc ggg     1680
 Val Asn Gly Phe Thr His Arg Ser Ser Val Pro Thr Thr Ser Thr Gly
 545                 550                 555                 560

 gtg gtc agc gag gag cca ttc aca ctg aac ttc acc atc aac aac ctg     1728
 Val Val Ser Glu Glu Pro Phe Thr Leu Asn Phe Thr Ile Asn Asn Leu
                 565                 570                 575

 cgc tac atg gcg gac atg ggc caa ccc ggc tcc ctc aag ttc aac atc     1776
 Arg Tyr Met Ala Asp Met Gly Gln Pro Gly Ser Leu Lys Phe Asn Ile
             580                 585                 590

 aca gac aac gtc atg aag cac ctg ctc agt cct ttg ttc cag agg agc     1824
 Thr Asp Asn Val Met Lys His Leu Leu Ser Pro Leu Phe Gln Arg Ser
         595                 600                 605

 agc ctg ggt gca cgg tac aca ggc tgc agg gtc atc gca cta agg tct     1872
 Ser Leu Gly Ala Arg Tyr Thr Gly Cys Arg Val Ile Ala Leu Arg Ser
     610                 615                 620

 gtg aag aac ggt tct gag aca cgg gtg gac ctc ctc tgc acc tac ctg     1920
 Val Lys Asn Gly Ser Glu Thr Arg Val Asp Leu Leu Cys Thr Tyr Leu
 625                 630                 635                 640

 cag ccc ctc agc ggc cca ggt ctg cct atc aag cag gtg ttc cat gag     1968
 Gln Pro Leu Ser Gly Pro Gly Leu Pro Ile Lys Gln Val Phe His Glu
                 645                 650                 655

 ctg agc cag cag acc cat ggc atc acc cgg ctg ggc ccc tac tct ctg     2016
 Leu Ser Gln Gln Thr His Gly Ile Thr Arg Leu Gly Pro Tyr Ser Leu
             660                 665                 670

 gac aaa gac agc ctc tac ctt aac ggt tac aat gaa cct ggt cta gat     2064
 Asp Lys Asp Ser Leu Tyr Leu Asn Gly Tyr Asn Glu Pro Gly Leu Asp
         675                 680                 685

 gag cct cct aca act ccc aag cca gcc acc aca ttc ctg cct cct ctg     2112
 Glu Pro Pro Thr Thr Pro Lys Pro Ala Thr Thr Phe Leu Pro Pro Leu
     690                 695                 700

 tca gaa gcc aca aca gcc atg ggg tac cac ctg aag acc ctc aca ctc     2160
 Ser Glu Ala Thr Thr Ala Met Gly Tyr His Leu Lys Thr Leu Thr Leu
 705                 710                 715                 720

 aac ttc acc atc tcc aat ctc cag tat tca cca gat atg ggc aag ggc     2208
 Asn Phe Thr Ile Ser Asn Leu Gln Tyr Ser Pro Asp Met Gly Lys Gly
                 725                 730                 735

 tca gct aca ttc aac tcc acc gag ggg gtc ctt cag cac ctg ctc aga     2256
 Ser Ala Thr Phe Asn Ser Thr Glu Gly Val Leu Gln His Leu Leu Arg
             740                 745                 750

 ccc ttg ttc cag aag agc agc atg ggc ccc ttc tac ttg ggt tgc caa     2304
 Pro Leu Phe Gln Lys Ser Ser Met Gly Pro Phe Tyr Leu Gly Cys Gln
         755                 760                 765

 ctg atc tcc ctc agg cct gag aag gat ggg gca gcc act ggt gtg gac     2352
 Leu Ile Ser Leu Arg Pro Glu Lys Asp Gly Ala Ala Thr Gly Val Asp
     770                 775                 780

 acc acc tgc acc tac cac cct gac cct gtg ggc ccc ggg ctg gac ata     2400
 Thr Thr Cys Thr Tyr His Pro Asp Pro Val Gly Pro Gly Leu Asp Ile
 785                 790                 795                 800

 cag cag ctt tac tgg gag ctg agt cag ctg acc cat ggt gtc acc caa     2448
 Gln Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His Gly Val Thr Gln
                 805                 810                 815

 ctg ggc ttc tat gtc ctg gac agg gat agc ctc ttc atc aat ggc tat     2496
 Leu Gly Phe Tyr Val Leu Asp Arg Asp Ser Leu Phe Ile Asn Gly Tyr
             820                 825                 830

 gca ccc cag aat tta tca atc cgg ggc gag tac cag ata aat ttc cac     2544
 Ala Pro Gln Asn Leu Ser Ile Arg Gly Glu Tyr Gln Ile Asn Phe His
         835                 840                 845

 att gtc aac tgg aac ctc agt aat cca gac ccc aca tcc tca gag tac     2592
 Ile Val Asn Trp Asn Leu Ser Asn Pro Asp Pro Thr Ser Ser Glu Tyr
     850                 855                 860

 atc acc ctg ctg agg gac atc cag gac aag gtc acc aca ctc tac aaa     2640
 Ile Thr Leu Leu Arg Asp Ile Gln Asp Lys Val Thr Thr Leu Tyr Lys
 865                 870                 875                 880

 ggc agt caa cta cat gac aca ttc cgc ttc tgc ctg gtc acc aac ttg     2688
 Gly Ser Gln Leu His Asp Thr Phe Arg Phe Cys Leu Val Thr Asn Leu
                 885                 890                 895

 acg atg gac tcc gtg ttg gtc act gtc aag gca ttg ttc tcc tcc aat     2736
 Thr Met Asp Ser Val Leu Val Thr Val Lys Ala Leu Phe Ser Ser Asn
             900                 905                 910

 ttg gac ccc agc ctg gtg gag caa gtc ttt cta gat aag acc ctg aat     2784
 Leu Asp Pro Ser Leu Val Glu Gln Val Phe Leu Asp Lys Thr Leu Asn
         915                 920                 925

 gcc tca ttc cat tgg ctg ggc tcc acc tac cag ttg gtg gac atc cat     2832
 Ala Ser Phe His Trp Leu Gly Ser Thr Tyr Gln Leu Val Asp Ile His
     930                 935                 940

 gtg aca gaa atg gag tca tca gtt tat caa cca aca agc agc tcc agc     2880
 Val Thr Glu Met Glu Ser Ser Val Tyr Gln Pro Thr Ser Ser Ser Ser
 945                 950                 955                 960

 acc cag cac ttc tac ctg aat ttc acc atc acc aac cta cca tat tcc     2928
 Thr Gln His Phe Tyr Leu Asn Phe Thr Ile Thr Asn Leu Pro Tyr Ser
                 965                 970                 975

 cag gac aaa gcc cag cca ggc acc acc aat tac cag agg aac aaa agg     2976
 Gln Asp Lys Ala Gln Pro Gly Thr Thr Asn Tyr Gln Arg Asn Lys Arg
             980                 985                 990

 aat att gag gat gcg ctc aac caa ctc ttc cga aac agc agc atc aag     3024
 Asn Ile Glu Asp Ala Leu Asn Gln Leu Phe Arg Asn Ser Ser Ile Lys
         995                1000                1005

 agt tat ttt tct gac tgt caa gtt tca aca ttc agg tct gtc ccc aac     3072
 Ser Tyr Phe Ser Asp Cys Gln Val Ser Thr Phe Arg Ser Val Pro Asn
    1010                1015                1020

 agg cac cac acc ggg gtg gac tcc ctg tgt aac ttc tcg cca ctg gct     3120
 Arg His His Thr Gly Val Asp Ser Leu Cys Asn Phe Ser Pro Leu Ala
1025                1030                1035                1040

 cgg aga gta gac aga gtt gcc atc tat gag gaa ttt ctg cgg atg acc     3168
 Arg Arg Val Asp Arg Val Ala Ile Tyr Glu Glu Phe Leu Arg Met Thr
                1045                1050                1055

 cgg aat ggt acc cag ctg cag aac ttc acc ctg gac agg agc agt gtc     3216
 Arg Asn Gly Thr Gln Leu Gln Asn Phe Thr Leu Asp Arg Ser Ser Val
            1060                1065                1070

 ctt gtg gat ggg tat tct ccc aac aga aat gag ccc tta act ggg aat     3264
 Leu Val Asp Gly Tyr Ser Pro Asn Arg Asn Glu Pro Leu Thr Gly Asn
        1075                1080                1085

 tct gac ctt ccc ttc tgg gct gtc atc ctc atc ggc ttg gca gga ctc     3312
 Ser Asp Leu Pro Phe Trp Ala Val Ile Leu Ile Gly Leu Ala Gly Leu
    1090                1095                1100

 ctg gga ctc atc aca tgc ctg atc tgc ggt gtc ctg gtg acc acc cgc     3360
 Leu Gly Leu Ile Thr Cys Leu Ile Cys Gly Val Leu Val Thr Thr Arg
1105                1110                1115                1120

 cgg cgg aag aag gaa gga gaa tac aac gtc cag caa cag tgc cca ggc     3408
 Arg Arg Lys Lys Glu Gly Glu Tyr Asn Val Gln Gln Gln Cys Pro Gly
                1125                1130                1135

 tac tac cag tca cac cta gac ctg gag gat ctg caa tga ctggaacttg      3457
 Tyr Tyr Gln Ser His Leu Asp Leu Glu Asp Leu Gln 
            1140                1145

 ccggtgcctg gggtgccttt cccccagcca gggtccaaag aagcttggct ggggcagaaa   3517

 taaaccatat tggtcggaaa aaaaaaaaa                                     3546




      <210> 239
      <211> 919
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (262)..(819)

      <400> 239
 tgggtttctg ggtcccagag gggaagttct cttcaaggta cagaaaccac gactccgcag     60

 agaaccgcag agaaccgcag agatggcagc atgaccagac cacggacagt gtccagaaga    120

 agaccaagga cagaacagag actaggtttg gtgagatggg acagattttg ggaaagatca    180

 tgatgagcca tcaaccgcag ccccaggaag agcggagccc ccagcggagc acctcagggt    240

 accccctcca ggaggtggtg g  atg atg aag tgt cgg gac cat cag ccc ctg     291
                          Met Met Lys Cys Arg Asp His Gln Pro Leu
                            1               5                  10

 ggg gta gat ccc agc ccc cca cgt agg tcc ctt ggc tgg aaa agg aag      339
 Gly Val Asp Pro Ser Pro Pro Arg Arg Ser Leu Gly Trp Lys Arg Lys
                  15                  20                  25

 agg gaa tgt ttg gat gaa tct gat gat gag cca gag aag gag ctc gcc      387
 Arg Glu Cys Leu Asp Glu Ser Asp Asp Glu Pro Glu Lys Glu Leu Ala
              30                  35                  40

 cct gag cct gag gag acc tgg gtg gcg gag acg ctg tgt ggc ctc aag      435
 Pro Glu Pro Glu Glu Thr Trp Val Ala Glu Thr Leu Cys Gly Leu Lys
          45                  50                  55

 atg aag gcg aag cga cgg cga gtg tcg ctc gtg ctc cct gag tac tac      483
 Met Lys Ala Lys Arg Arg Arg Val Ser Leu Val Leu Pro Glu Tyr Tyr
      60                  65                  70

 gag gcc ttc aac agg ctg ctt ggt agg agg aca ccc cag aga gca cct      531
 Glu Ala Phe Asn Arg Leu Leu Gly Arg Arg Thr Pro Gln Arg Ala Pro
  75                  80                  85                  90

 cca atc ctg ttc ttt cta aag agg aaa ctt cca ata acc aca ctt ttc      579
 Pro Ile Leu Phe Phe Leu Lys Arg Lys Leu Pro Ile Thr Thr Leu Phe
                  95                 100                 105

 caa tgg gaa aaa tat gcc cca gtg ggt gag ctc tcc atg cgg gag gac      627
 Gln Trp Glu Lys Tyr Ala Pro Val Gly Glu Leu Ser Met Arg Glu Asp
             110                 115                 120

 tct gaa gtg atc act cat gag gga cac tta gga gac aac aga gga tta      675
 Ser Glu Val Ile Thr His Glu Gly His Leu Gly Asp Asn Arg Gly Leu
         125                 130                 135

 ggt aga ctt gat aaa ggg aaa ccc tgt cct gct tct cac act gac atc      723
 Gly Arg Leu Asp Lys Gly Lys Pro Cys Pro Ala Ser His Thr Asp Ile
     140                 145                 150

 tgc tct cta atc aca gag gat cct gtc att aaa aga ttc ctg gcc tgg      771
 Cys Ser Leu Ile Thr Glu Asp Pro Val Ile Lys Arg Phe Leu Ala Trp
 155                 160                 165                 170

 gac aaa gat ctg agg gtg tcg gac aag gta agg atg atc tcc atg taa      819
 Asp Lys Asp Leu Arg Val Ser Asp Lys Val Arg Met Ile Ser Met 
                 175                 180                 185

 ctgctcctgt tccaacgcat ggctgggggg agggcgcagc ttccaaaccc acagttctcc    879

 ctccaccacc tcccaccaga tgctcctaca gtcttttttt                          919




      <210> 240
      <211> 2567
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (652)..(993)

      <400> 240
 tcgcgcgcgc cgccgccccg cgctgctgaa gctggcgtcg ctgccgccct cgtgccacgc     60

 accgccgcac gcgctggagc aggaggagac gccgctgtga cgccgccggc gggaagggtc    120

 cgcgcgccat ggctggccgc tcgcgccctt tcccaccgct gccgggaaac cgaggctcgc    180

 cccaaacgga tttgcgtgaa accagcccaa ggttccgggc ccccccaacc gagccccgcg    240

 cccggggact gactcgggga ccgactcagg gacctcccga gcgccaggac tcagggcccg    300

 acctgcagcg gctgcaggcc cagcgcccgc aagcggcctg ggccgagcgc cgtttccagg    360

 ccctcgccag gtctttgaac tgcaggtaaa gtggcaggaa cgtcttccgt ctgctcagcg    420

 tttggggatt tagactccta aagccagtac ctgccccgtt tcccccccag gttccgtcct    480

 gcccgcgccc ggtctcaggg tggcggcccc ggacacggcc cgtccccaca gacgaggtct    540

 ccggcctgag ctgtcgcacc tggcgcggag gtcgcccggg gtgccctggc tgggtgagag    600

 gtggcctggc gggccggagc ttgccaagaa tcacggccag tccttaagtg g atg gtg     657
                                                          Met Val
                                                            1

 ggg ccc agc agc tgc tct gtc ccc ctt aac aaa cca ggg ggc atg gag      705
 Gly Pro Ser Ser Cys Ser Val Pro Leu Asn Lys Pro Gly Gly Met Glu
           5                  10                  15

 ggg ccc agg gca ccg ccc ccc tac cag gct cag gcc ctc caa gga gaa      753
 Gly Pro Arg Ala Pro Pro Pro Tyr Gln Ala Gln Ala Leu Gln Gly Glu
      20                  25                  30

 cct gct gag acc cct gag cct gtc cta gac ccc gga ccc ctg acc ctt      801
 Pro Ala Glu Thr Pro Glu Pro Val Leu Asp Pro Gly Pro Leu Thr Leu
  35                  40                  45                  50

 ccc acc cct tcc agc gtc cca ggg cga ggc ctt gga cag agc tcc tgg      849
 Pro Thr Pro Ser Ser Val Pro Gly Arg Gly Leu Gly Gln Ser Ser Trp
                  55                  60                  65

 tcc tct gca ggg aga cca tcc agc cca agc tct ggg agg cac agt cca      897
 Ser Ser Ala Gly Arg Pro Ser Ser Pro Ser Ser Gly Arg His Ser Pro
              70                  75                  80

 ttg agt ggg cgg agg ccg cgg gtg ctg agc cgg gga ggg tgc tcg gag      945
 Leu Ser Gly Arg Arg Pro Arg Val Leu Ser Arg Gly Gly Cys Ser Glu
          85                  90                  95

 tcc atc cat ccc tca gac ggc aag tcc cac agg gtc caa ccc acc tga      993
 Ser Ile His Pro Ser Asp Gly Lys Ser His Arg Val Gln Pro Thr 
     100                 105                 110

 aacctgcctg cacggtggaa gtggtggagg tggacactcc taggggcttt tctaaagcta   1053

 gactcgcagc tccttgctca ggaaaattaa actattcacg tttcagatca agtgttgaca   1113

 gtcaccagtc aggaggagtt cttaaagagt tttatgttga ctgaatattg cacattgagt   1173

 ccccattgag tccctggtgg gaaaagtcca caatttccca ttgatagctt tttactgttg   1233

 tgaaaaaggg aagcgtcagc cacacaaaag cctgcatgac cgctgcttcg gagaagctct   1293

 cgaccctaac tgcagtcact gttacttgga tcagatcaag cgcagtgact ttttgggatt   1353

 cagtggttat tctccacact tcgtagccat ttcaaccaac tctgagcaca aaatgcagcc   1413

 atcctctatg cagcaagccc tgcccagtca gtgaccctac tggacagatc caaggccagc   1473

 cctggttccc tgctgcagcc accgtcctga cgttcatcgg agcaggccgg ggcctggcct   1533

 tcccggcaca agtggctgtt ctgacaggcc cccagtttgt cccatctgaa ctgctgggag   1593

 gtttccgggt ggccagagga gcaaagctgc cttccaagtg cctgtctgtg cctgggagaa   1653

 cagagcagga gcgtcgtgcg gtccaccgcg cagtgcatgg cgattccagg cgctgaacaa   1713

 ctcccctgga cccttgggcc tgcatctgac tcccagctgc agagtcagaa gctgagtcca   1773

 ggcaactgct tggccactcc cgatcgctcc tccctggaca cccggttacc aaagtcagca   1833

 aagaagatgc ggtaatcgcc gcctgatctc cacatggtga acacaacact cccaccaaca   1893

 cctccttgac tggtcggtct tcagcaccgg gggtgggcag gcaggtgttc tgtgttgacg   1953

 agaattgcac aggctaaaca caaacacgga accagagtga gaacacctca ctcacggcag   2013

 cccaggctgc tccctaccag gtgacggagc gagccggggc tgtgggtgcc aggggctgag   2073

 tgctagggac tcgtcatgag tggggatccc cacgttcctg tcactgctgt caaacagaag   2133

 gtaaacagtc ttatgaatgt atttccttag gaaaacttgt aaaaactttt attaggatat   2193

 ctatttaata ctgaactttg gcctactttg tgatagacta taaacaaatt gaggaaatca   2253

 ctatttctca cttctgtatt ttctcaaaaa taattttgtt acagagttca atatactgtg   2313

 taccattgat cttctattgt gaaagcaaag aatttcatca aaatatttta aattatgagt   2373

 gaaaattgtg tatgttaatt ttgcagctat aatattaatc aaattttgtg taattctaat   2433

 cacaaaatga cgtgccttaa gtgcccctcc agctgtgggt tggcagtgtc cagacaggga   2493

 gggcccatca ccgaaatcct gaacgattac tagaccaatt ctattaaaaa catttcaagg   2553

 caaaaaaaaa aaaa                                                     2567




      <210> 241
      <211> 1504
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(950)

      <400> 241
 accagccttc cgagcctgag gcccttggct gggtaatgga cttactcggt tctcaa         56                                                                 
 atg ggc aac tta cac gat agg tac aac cgc ctt gaa agg ctg cga agc      104
 Met Gly Asn Leu His Asp Arg Tyr Asn Arg Leu Glu Arg Leu Arg Ser
   1               5                  10                  15

 ctt ctc cct cat aca gcc cac gaa cct ttt ccc ctt cat agc tac aaa      152
 Leu Leu Pro His Thr Ala His Glu Pro Phe Pro Leu His Ser Tyr Lys
              20                  25                  30

 gaa ata aag gta att caa gcc aat aat gac ata cca gtt gaa gaa atc      200
 Glu Ile Lys Val Ile Gln Ala Asn Asn Asp Ile Pro Val Glu Glu Ile
          35                  40                  45

 cat tct cca ttt aca aca ata ctt ttg aga aca ttt ttg aat tac ctc      248
 His Ser Pro Phe Thr Thr Ile Leu Leu Arg Thr Phe Leu Asn Tyr Leu
      50                  55                  60

 ctg cat ttg gcg tac cac att tat cat gaa gaa ttc caa aag aga agc      296
 Leu His Leu Ala Tyr His Ile Tyr His Glu Glu Phe Gln Lys Arg Ser
  65                  70                  75                  80

 cca tcc ctc ttc ttg tgt ttt aca aaa ctg atg acc gag aac att cgt      344
 Pro Ser Leu Phe Leu Cys Phe Thr Lys Leu Met Thr Glu Asn Ile Arg
                  85                  90                  95

 cca aat gcc tgc cag ata aaa ggc aat tta ttc cgt gag caa cag cgg      392
 Pro Asn Ala Cys Gln Ile Lys Gly Asn Leu Phe Arg Glu Gln Gln Arg
             100                 105                 110

 acg ctc tac tct atg agt tac atg aat aag tgc tgg gag att tat ctc      440
 Thr Leu Tyr Ser Met Ser Tyr Met Asn Lys Cys Trp Glu Ile Tyr Leu
         115                 120                 125

 gct tac tgc aga ccc agt gca gcg cct ccc cac gag cct acg atg aag      488
 Ala Tyr Cys Arg Pro Ser Ala Ala Pro Pro His Glu Pro Thr Met Lys
     130                 135                 140

 atg aga cac ttc ctc tgg atg ctg aaa gac ttt aaa atg ata aat aaa      536
 Met Arg His Phe Leu Trp Met Leu Lys Asp Phe Lys Met Ile Asn Lys
 145                 150                 155                 160

 gaa tta aca gca gct aca ttt atg gag gtc ata gca gag gat aat cgt      584
 Glu Leu Thr Ala Ala Thr Phe Met Glu Val Ile Ala Glu Asp Asn Arg
                 165                 170                 175

 ttc ata tat gat gga att gac agc aac ttt gaa cct gag ctg gtt ttc      632
 Phe Ile Tyr Asp Gly Ile Asp Ser Asn Phe Glu Pro Glu Leu Val Phe
             180                 185                 190

 ctg gaa ttc ttt gaa gct ctc tta agc ttt gca ttc atc tgt gtt act      680
 Leu Glu Phe Phe Glu Ala Leu Leu Ser Phe Ala Phe Ile Cys Val Thr
         195                 200                 205

 gac caa atg act aaa tcc tat aca aat gtt cca gct gat gat gtg tct      728
 Asp Gln Met Thr Lys Ser Tyr Thr Asn Val Pro Ala Asp Asp Val Ser
     210                 215                 220

 gga aat aaa cat gaa act att tat aca ata cta aat cag gac gcc cag      776
 Gly Asn Lys His Glu Thr Ile Tyr Thr Ile Leu Asn Gln Asp Ala Gln
 225                 230                 235                 240

 aac aag agt ccc agc gcg gtc atg agc cac gaa tcg gat gct gct cac      824
 Asn Lys Ser Pro Ser Ala Val Met Ser His Glu Ser Asp Ala Ala His
                 245                 250                 255

 tct gac agt gcc agg tca tct tcc agc aag tta gaa ctc tcg cct gat      872
 Ser Asp Ser Ala Arg Ser Ser Ser Ser Lys Leu Glu Leu Ser Pro Asp
             260                 265                 270

 gtt aac aaa ata agg aaa tca gag ccc aag atc aag aag tct gta agt      920
 Val Asn Lys Ile Arg Lys Ser Glu Pro Lys Ile Lys Lys Ser Val Ser
         275                 280                 285

 cat gaa aga gtc tcc aaa atg aat ttt taa t tgactggaaa agggatcacc      971
 His Glu Arg Val Ser Lys Met Asn Phe 
     290                 295

 tttttctcat ctgagagcaa gaaatatgag agacccaagg atgatcgaga ggaagagttc   1031

 aacacgtggg tcaataatat gtacgtcttc tttgtgaaca cgctctttca tgcgtataaa   1091

 cgtgaagaag ctatcaagga gaaaataagg gcagacaggt tacgtagcac agcacaggcc   1151

 cagcagcgga agatggaaga tgacgaactg gaagcaaggc tgaacatctt catcttgaga   1211

 gaggaagagg ccaagagaca tgactatgag gtggacatca cagtgctcaa ggagccggca   1271

 gacgtgtcat cctctcacct catactggac cctcccaagg aggatgtgac cgtgtcccca   1331

 tccagcaaga ccatcaccag caagaagaag aaaaagtaga gagacacgag gacacacaca   1391

 caggcttagg atggcacgtg ctgtaagatt tcctgagcat tacagttctt agcactgaac   1451

 tcgtcacagt gttttaacat accccttggc ccactgcatc tcaggtttcc tac          1504




      <210> 242
      <211> 733
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (343)..(501)

      <400> 242
 tcaccacaag ctgattgaaa aacctttgtg ccttaagtga accgtggcag tagcctggaa     60

 gtactcccct gggcctgtgg tggtgaaggc cagggggcga ggctctcctg ccctgaaacc    120

 tattttgtca agcaggggtc tcagagggag accctggaga tggtgggcac aggacaggag    180

 cagcagaacc ttcaccagga ggatcccccc tggtcctgtg acccatgcgt ccagctcggg    240

 gccctcaggt gggggctgca aagaagctgg ttgtcccttg aaagctggag caagtgagca    300

 ggtacacttg gacctgaggc tgtggttttt ccccaggctg ag   atg gat ctt gag     354
                                                  Met Asp Leu Glu
                                                    1

 gcg gca aag aac gga aca gcc tgg cgc ccc acg agc gcg gag ggc gac      402
 Ala Ala Lys Asn Gly Thr Ala Trp Arg Pro Thr Ser Ala Glu Gly Asp
   5                  10                  15                  20

 ttt gaa ctg ggc atc agc agg tac atc ccc agc agc cac tgg ctt ttc      450
 Phe Glu Leu Gly Ile Ser Arg Tyr Ile Pro Ser Ser His Trp Leu Phe
                  25                  30                  35

 cgt tac acg cca atc agc agg act aag ttc acc ctt gga aag aag ttg      498
 Arg Tyr Thr Pro Ile Ser Arg Thr Lys Phe Thr Leu Gly Lys Lys Leu
              40                  45                  50

 taa aaat cggttgatgc ctttgaagac ctttgttttg gaggcttctt tgaagggtct      555
 


 tgcatccggt tctgaccttg gagcaaacgt gttgtgtggc ctcaaagaat gtcactgagg    615

 ctccttttgg aacagattca ggaagaaaag gctgtcttga aaagagctcc cttccctttg    675

 tgcagggggg attcaatgaa tatctgcatt ggataacatt cattgtatta cgtaactc      733




      <210> 243
      <211> 1579
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (241)..(1284)

      <400> 243
 cccgggtcga cgatttcgtc tgcctggacg tccctgcggg ccttgttggt tatcacccaa     60

 cttctcccgc ctcggttttt agcagaaacg tgacggggct ggactttgat cgccgagggc    120

 tctctgctct tcagagtctg cttggaacgg gataagtgga accaaaatta caagggccat    180

 ggattgtcaa agggaaaaga gcgagagcag agagcatcga tccggttcaa gaccaccctc    240
                                                                 
 atg aac aca ctc atg gac gtc ctt cgc cac agg cca gga tgg gtg gaa      288
 Met Asn Thr Leu Met Asp Val Leu Arg His Arg Pro Gly Trp Val Glu
   1               5                  10                  15

 gtg aag gac gaa ggg gag tgg gat ttc tac tgg cgt gac gtc agc tgg      336
 Val Lys Asp Glu Gly Glu Trp Asp Phe Tyr Trp Arg Asp Val Ser Trp
              20                  25                  30

 ctc cgg gag aac ttc gac cac acc tac atg gat gaa cat gtg cgg atc      384
 Leu Arg Glu Asn Phe Asp His Thr Tyr Met Asp Glu His Val Arg Ile
          35                  40                  45

 agt cac ttc cgg aac cac tat gag ctg acc cgg aag aac tac atg gtg      432
 Ser His Phe Arg Asn His Tyr Glu Leu Thr Arg Lys Asn Tyr Met Val
      50                  55                  60

 aag aac ctg aag cgg ttc cgg aag cag ctg gag cgt gag gca gga aag      480
 Lys Asn Leu Lys Arg Phe Arg Lys Gln Leu Glu Arg Glu Ala Gly Lys
  65                  70                  75                  80

 ctg gag gca gcc aag tgt gac ttc ttc ccc aaa acc ttt gag atg cct      528
 Leu Glu Ala Ala Lys Cys Asp Phe Phe Pro Lys Thr Phe Glu Met Pro
                  85                  90                  95

 tgc gag tac cac ctg ttt gta gag gag ttt cgc aaa aac cca gga atc      576
 Cys Glu Tyr His Leu Phe Val Glu Glu Phe Arg Lys Asn Pro Gly Ile
             100                 105                 110

 acc tgg atc atg aag cct gta gcc cgg tct caa ggg aaa ggc atc ttc      624
 Thr Trp Ile Met Lys Pro Val Ala Arg Ser Gln Gly Lys Gly Ile Phe
         115                 120                 125

 ctc ttc tgt agg ctg aag gac atc gtg gac tgg agg aag gac aca aga      672
 Leu Phe Cys Arg Leu Lys Asp Ile Val Asp Trp Arg Lys Asp Thr Arg
     130                 135                 140

 agc tct gac gac cag aaa gat gat att ccc gtg gag aac tat gtg gct      720
 Ser Ser Asp Asp Gln Lys Asp Asp Ile Pro Val Glu Asn Tyr Val Ala
 145                 150                 155                 160

 cag cgt tac att gaa aat cct tac ctg ata gga ggc cgc aag ttt gac      768
 Gln Arg Tyr Ile Glu Asn Pro Tyr Leu Ile Gly Gly Arg Lys Phe Asp
                 165                 170                 175

 ctg cgt gtc tat gtg ctg gtg atg tcg tac atc ccg ctg cgg gcc tgg      816
 Leu Arg Val Tyr Val Leu Val Met Ser Tyr Ile Pro Leu Arg Ala Trp
             180                 185                 190

 ctc tac cgg gat ggc ttt gcc cga ttc tcc aac acc cgc ttc aca ctg      864
 Leu Tyr Arg Asp Gly Phe Ala Arg Phe Ser Asn Thr Arg Phe Thr Leu
         195                 200                 205

 aac agc att gat gac cag tat gtt cac ccc acc aac gtg gct gtg caa      912
 Asn Ser Ile Asp Asp Gln Tyr Val His Pro Thr Asn Val Ala Val Gln
     210                 215                 220

 aaa aca tct ccc gac tac cac cca aag aag ggc tgc aag tgg acg ctg      960
 Lys Thr Ser Pro Asp Tyr His Pro Lys Lys Gly Cys Lys Trp Thr Leu
 225                 230                 235                 240

 cag cgc ttc cgg cag tac ctg gcg tcc aaa cac ggg ccc gag gca gtg     1008
 Gln Arg Phe Arg Gln Tyr Leu Ala Ser Lys His Gly Pro Glu Ala Val
                 245                 250                 255

 gag aca ctc ttc agg gac atc gac aac atc ttt gtc aaa agc ctg cag     1056
 Glu Thr Leu Phe Arg Asp Ile Asp Asn Ile Phe Val Lys Ser Leu Gln
             260                 265                 270

 agt gtg cag aag gtg atc atc agt gac aag cac tgc ttc gag ctg tac     1104
 Ser Val Gln Lys Val Ile Ile Ser Asp Lys His Cys Phe Glu Leu Tyr
         275                 280                 285

 ggc tat gac atc ctc atc gac cag gac ctc aag ccg tgg ctc ctg gag     1152
 Gly Tyr Asp Ile Leu Ile Asp Gln Asp Leu Lys Pro Trp Leu Leu Glu
     290                 295                 300

 gtc aat gcg tcc cca tca ctg aca gcc agc agc cag gaa gac tat gag     1200
 Val Asn Ala Ser Pro Ser Leu Thr Ala Ser Ser Gln Glu Asp Tyr Glu
 305                 310                 315                 320

 ctc aag acc tgc ctc ctg gaa gac acc ctg cat gtt gtg gac atg gaa     1248
 Leu Lys Thr Cys Leu Leu Glu Asp Thr Leu His Val Val Asp Met Glu
                 325                 330                 335

 gcg agc ttt tcc ccg att att cca gca gaa gtt tga gggc tgattctcct     1298
 Ala Ser Phe Ser Pro Ile Ile Pro Ala Glu Val 
             340                 345

 tgctggtaac tgggacacat tcccattcct aaaccactca ctgtgactct gcttgaccag   1358

 gctcacggaa agggagaaac gagtcggcgg ctttgacctc atgtggaatg atggccctgt   1418

 taacagagag gagggggctc ctgacctggc gagaatggta gactatgcga ccaacacaca   1478

 cgctaggatg taaggccagg cggcgagtgt cacaagggat ggtgccatgg gagacaccgt   1538

 ttaacctagg tggcatctgg ctaagacttt caatgatcca c                       1579




      <210> 244
      <211> 2427
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (661)..(1383)

      <400> 244
 ttcctgggag aagccgggct gcctcacgag gcactaggaa ctacatttcc cggaaagtac     60

 taaatttaag aatgtttgga caactcattc caggtcacct atagcctatg agagaggaag    120

 aatatatttt gacaattatc ggcgctgtgt cagcagtgtt gcatctgagc caagaaaact    180

 ttatgaaatg ccaaaatgtt ccaaatcaga aaaaatagag gatgctttat tatgggaatg    240

 cccagtggga gatatacttc ccaattcatc agattataag tcctcactca tagcactgac    300

 tgctcataat tggctacttc gtatatcagc aactacggga aaaatccttg agaaaatata    360

 tcttgcacct tattgcaaat tcagatactt gagctgggac actcctcaag aagtcattgc    420

 agttaagtca gctcagaaca gaggctcagc agtggcccgg caggcaggca ttcaacaaca    480

 tgttttgctg taccttgcag tgttccgagt tctacctttt tcacttgtag ggattctaga    540

 gatcaacaaa aagatttttg ggaacgttac agatgctacc ttgtctcatg gaatactgat    600

 tgtgatgtac agctcaggac tggtcagact ctatagcttc caaaccatcg ctgaacagac    660
                                                                 
 atg cca cca ctg ctc ttt gag gtg tca tcc ctg gag aat gct ttt cag      708
 Met Pro Pro Leu Leu Phe Glu Val Ser Ser Leu Glu Asn Ala Phe Gln
   1               5                  10                  15

 att gga ggc cat cct tgg cac tac atc gtc aca cct aat aag aag aaa      756
 Ile Gly Gly His Pro Trp His Tyr Ile Val Thr Pro Asn Lys Lys Lys
              20                  25                  30

 cag aaa gga gtt ttc cat att tgt gcc cta aaa gac aat tcc ctg gca      804
 Gln Lys Gly Val Phe His Ile Cys Ala Leu Lys Asp Asn Ser Leu Ala
          35                  40                  45

 aaa aat ggg atc cag gaa atg gat tgt tgt tct cta gaa tct gac tgg      852
 Lys Asn Gly Ile Gln Glu Met Asp Cys Cys Ser Leu Glu Ser Asp Trp
      50                  55                  60

 atc tat ttc cat cct gat gct tct ggt aga ata ata cat gtt ggt cca      900
 Ile Tyr Phe His Pro Asp Ala Ser Gly Arg Ile Ile His Val Gly Pro
  65                  70                  75                  80

 aat caa gtc aaa gtt ttg aag cta act gaa ata gaa aat aat agt tct      948
 Asn Gln Val Lys Val Leu Lys Leu Thr Glu Ile Glu Asn Asn Ser Ser
                  85                  90                  95

 cag cat cag atc tct gaa gat ttt gtc att ttg gcc aac agg gag aac      996
 Gln His Gln Ile Ser Glu Asp Phe Val Ile Leu Ala Asn Arg Glu Asn
             100                 105                 110

 cat aaa aat gaa aat gta ctc act gtt aca gct tct gga cgg gtg gta     1044
 His Lys Asn Glu Asn Val Leu Thr Val Thr Ala Ser Gly Arg Val Val
         115                 120                 125

 aaa aaa agt ttt aac ctt ctg gat gat gac cca gaa caa gag act ttc     1092
 Lys Lys Ser Phe Asn Leu Leu Asp Asp Asp Pro Glu Gln Glu Thr Phe
     130                 135                 140

 aaa att gtg gac tat gaa gat gag tta gat ttg ctt tct gtg gta gct     1140
 Lys Ile Val Asp Tyr Glu Asp Glu Leu Asp Leu Leu Ser Val Val Ala
 145                 150                 155                 160

 gtt act caa ata gat gct gaa gga aaa gct cac ctg gat ttc cac tgt     1188
 Val Thr Gln Ile Asp Ala Glu Gly Lys Ala His Leu Asp Phe His Cys
                 165                 170                 175

 aat gaa tat gga act tta ctt aaa agc att cca cta gtg gag tca tgg     1236
 Asn Glu Tyr Gly Thr Leu Leu Lys Ser Ile Pro Leu Val Glu Ser Trp
             180                 185                 190

 gat gtg aca tat agc cat gaa gtc tac ttt gac aga gac ttg gtg cta     1284
 Asp Val Thr Tyr Ser His Glu Val Tyr Phe Asp Arg Asp Leu Val Leu
         195                 200                 205

 cac ata gag cag aaa ccc aac aga gtc ttc agc tgc tat gtt tac cat     1332
 His Ile Glu Gln Lys Pro Asn Arg Val Phe Ser Cys Tyr Val Tyr His
     210                 215                 220

 atg ata tgt gac act ggg gaa gaa gaa gaa acc ata aac aga agc tgt     1380
 Met Ile Cys Asp Thr Gly Glu Glu Glu Glu Thr Ile Asn Arg Ser Cys
 225                 230                 235                 240

 taa aaag agtgagataa ttgtaaccta agagactttt agccaaacac cccagcagct     1437
 


 gcgtccaatc cattttatta tctgcatggc acattctcca gtattttcca aaaaagtctt   1497

 gtgttgactt cagatgacta tgacttcttt tttaaactct tgctgtaaaa gatggtgagg   1557

 acttcatttt ttttaaaggt tttttagaat actgttccaa gaagtttagt gttttgcagc   1617

 tttgagctag gtggtaatgc aaatataaaa tgctgggaac agaaaaggac aggttaattc   1677

 caattgttga ggagttaagt cattgatggg gtgggtcatt gatgagttct taaaggatgg   1737

 tatggaattt tgtttgttaa ggctaggaaa gacagggaga gacaaaagta aacatgcaga   1797

 aagaaatctt atatcctcta taccaaactt tgcttaagga tgagaaatga gatgtgttat   1857

 gtgagaacat tattttgagc ccaaaatgtg tcatcacagt ttttaaaaat cttatatatg   1917

 tatttatatg tgtttcgtat ttgtatatag tatcaagaat tggttctagt tcccaaatta   1977

 tcttttcttc cttggttttg ttctcttggc ttgatgttca cattggatat ttgtgtttct   2037

 atataggcta atgtaaaaga tgccaagcaa accttaagtg aaattgtttt ctgatttgca   2097

 tcctgtttag ctcttaatgt atctaaggat gttctcatct caccattcta ctcatttagt   2157

 gagttttctg atcttgttta ggcaatattt gcatacttat gcaataagat aaaggtaccc   2217

 ttgcctgcag tagttctgtt tcctgtagaa aagtggataa agagtcccag aagaagttct   2277

 tactagcttg ggagttacct gattaaccag agaaaatttt tggcttactt atggaacaag   2337

 cattatttct tctttgttag gaaagatcta aatatggtcc ttgactttta ataatcattc   2397

 tttagaatgt taaataaagg caacccaagt                                    2427




      <210> 245
      <211> 1224
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (278)..(847)

      <400> 245
 tttcgtgacg aatggaggtc actgttggaa tttagactgt gggggtagac tcagtccgat     60

 agccctactt cccgcgggtg ttgaccccta ctgtcgcggg ctcggcggtg cttttcgggg    120

 actcgttctg catgccttac cgggtagggc aggttagtgg ttccgctccg agagtcagga    180

 aaaaagctcc aaacaagcga gactgagaga ccagtagctg gctttagacc agttttagcc    240

 gggggattcg tggttttgta tttccttagc gtgctgg atg tat gga aac cgt agt     295
                                          Met Tyr Gly Asn Arg Ser
                                            1               5

 aaa cag cat gaa tcg tgt ttt gtt ttt gaa cag acc act ggc ctt gtg      343
 Lys Gln His Glu Ser Cys Phe Val Phe Glu Gln Thr Thr Gly Leu Val
              10                  15                  20

 gga ttg gct gtg tgc aat act cct cac gag gta tgt acc ttt gtt ctt      391
 Gly Leu Ala Val Cys Asn Thr Pro His Glu Val Cys Thr Phe Val Leu
          25                  30                  35

 tct tcg ttc ttg aat tcc caa gga aga cta aat tcc tgt cac ttt gct      439
 Ser Ser Phe Leu Asn Ser Gln Gly Arg Leu Asn Ser Cys His Phe Ala
      40                  45                  50

 tat tgc agg gtt aac ggg ata cag atg ttt caa gcc ctt aat tac aag      487
 Tyr Cys Arg Val Asn Gly Ile Gln Met Phe Gln Ala Leu Asn Tyr Lys
  55                  60                  65                  70

 ccg cgt gag ctc ttg aga cac ggg cgc tgt cca cct act tcg ttg atc      535
 Pro Arg Glu Leu Leu Arg His Gly Arg Cys Pro Pro Thr Ser Leu Ile
                  75                  80                  85

 cga tgt cac att ttt att tat ttt tgc cat gac ctc ttt att aag cca      583
 Arg Cys His Ile Phe Ile Tyr Phe Cys His Asp Leu Phe Ile Lys Pro
              90                  95                 100

 gtt ttc ttg ttg act ttt tcc ttg aca ttt tca tgg ctt cac ttg tgc      631
 Val Phe Leu Leu Thr Phe Ser Leu Thr Phe Ser Trp Leu His Leu Cys
         105                 110                 115

 ttg ctt ctg tca gcg cca tct caa att tat atc tcc gtt ttc cat ctt      679
 Leu Leu Leu Ser Ala Pro Ser Gln Ile Tyr Ile Ser Val Phe His Leu
     120                 125                 130

 ttc tcc ttg cct tac cgt ttc tgc tta ggt gcg ttg gat tac ata tat      727
 Phe Ser Leu Pro Tyr Arg Phe Cys Leu Gly Ala Leu Asp Tyr Ile Tyr
 135                 140                 145                 150

 tta ggc tta cta aag gta ctg ccc cct ttt cct tct gtt agg tct ttt      775
 Leu Gly Leu Leu Lys Val Leu Pro Pro Phe Pro Ser Val Arg Ser Phe
                 155                 160                 165

 cca tct gta ttc acg aat gtt ttc atc aaa aaa acc cac aaa att ttt      823
 Pro Ser Val Phe Thr Asn Val Phe Ile Lys Lys Thr His Lys Ile Phe
             170                 175                 180

 tta ttc ttc ttg tcc ctt cta taa tcacaccatt tctttgcttc actttacaga     877
 Leu Phe Phe Leu Ser Leu Leu 
         185

 taactcaaaa gagttatctc tattttctcc aatttctttc ttattcaccc ttgaatgcac    937

 tcagtcaccc ttggcgtttt tcaagttcac caattatctc catgctgcca aatccaatgg    997

 tcagctcata tttctcacct tcattgacct aatagcagcg tttttttgac acatttgaca   1057

 ctttttccat cacgctcttt tcaagttcac cagttatctc catgttgcca aatccaatgg   1117

 tcagcttatg tttctcacct tcattgacct aatagcagcg tttttttttt tttttgacac   1177

 attggaaact ttttccatca ggcccttttt ttactgggct tcaggag                 1224




      <210> 246
      <211> 1178
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (203)..(655)

      <400> 246
 gagaaacaat aggacggaaa cgccgaggaa cccggctgag gcggcagcag agcatcctgg     60

 ccagaacaag ccaaggagcc aagacgagag ggacacacgg acaaacaaca gacagaagac    120

 gtactggccg ctggactccg ctgcctcccc catctccccg ccatctgcgc ccggaggatg    180

 agcccagcct tcagggccat gg atg tgg agc ccc gcg cca aag gcg tcc ttc     232
                          Met Trp Ser Pro Ala Pro Lys Ala Ser Phe
                            1               5                  10

 tgg agc cct ttg tcc acc agg tcg ggg ggc act cat gcg tgc tcc gct      280
 Trp Ser Pro Leu Ser Thr Arg Ser Gly Gly Thr His Ala Cys Ser Ala
                  15                  20                  25

 tca atg aga caa ccc tgt gca agc ccc tgg tcc caa ggg aac atc agt      328
 Ser Met Arg Gln Pro Cys Ala Ser Pro Trp Ser Gln Gly Asn Ile Ser
              30                  35                  40

 tct acg aga ccc tcc ctg ctg aga tgc gca aat tca ctc ccc agt aca      376
 Ser Thr Arg Pro Ser Leu Leu Arg Cys Ala Asn Ser Leu Pro Ser Thr
          45                  50                  55

 aag gac aaa gcc aaa ggc ccc ttg tta gct ggc cat ccc tgc ccc att      424
 Lys Asp Lys Ala Lys Gly Pro Leu Leu Ala Gly His Pro Cys Pro Ile
      60                  65                  70

 ttt tcc cct ggt cct ttc ccc tgt ggc cac agg gaa gtg tgg cct gaa      472
 Phe Ser Pro Gly Pro Phe Pro Cys Gly His Arg Glu Val Trp Pro Glu
  75                  80                  85                  90

 tac ccc acc ccg gct cct ctg cac cca gag ctg ggg gcc acc tca gaa      520
 Tyr Pro Thr Pro Ala Pro Leu His Pro Glu Leu Gly Ala Thr Ser Glu
                  95                 100                 105

 gtg tca tct ctc tct gag cac gca ttc ccc tgc agc agt cga gga ctg      568
 Val Ser Ser Leu Ser Glu His Ala Phe Pro Cys Ser Ser Arg Gly Leu
             110                 115                 120

 agc aga ttg agt gat gct ggg gca gag agg cct ggg agg aaa ggt gtt      616
 Ser Arg Leu Ser Asp Ala Gly Ala Glu Arg Pro Gly Arg Lys Gly Val
         125                 130                 135

 cag cca gtc gtt tgt aag gcg ctc gtc ggc acc tgc tga aacgccccca       665
 Gln Pro Val Val Cys Lys Ala Leu Val Gly Thr Cys 
     140                 145                 150

 cctgacagcc ccatcctcaa agactgtctt aattactcat ggcaggttct agagacttaa    725

 ggggaaaagc tgctttcaag gccaccacat gtctgtgctc cccaaccagc tctatctgcc    785

 ttgtgttcat tttgttattt tgtgacgtga gactgcaaag accaataaaa acatatttta    845

 taagaacaaa aggcctgggt gcctacccgt gtgggggcac tgtgggaagc ctttgctagg    905

 gtgtcttgtg ctgtgtggtt tgttttgttt gcccctttat tttgctttgc ttacccagtc    965

 ttcccttact cttggatgct tcttaaccct caggcaaacc tgtgttcccc ctgtattcag   1025

 gctctgcttt aaagcaagcc atgaggctgt tggagtttct gtttagggca ttaaaaattc   1085

 ccgcaaacta taaagagcaa tgttttcagt cttttaggat tagaagaatt acataaaaat   1145

 taataaacat tttcaatgat ggaaaaaaaa aaa                                1178




      <210> 247
      <211> 1075
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(625)

      <400> 247
 cttcaac  atg gcc gaa gca agt agc gcc aat cta ggc agc ggc tgt gag      49
          Met Ala Glu Ala Ser Ser Ala Asn Leu Gly Ser Gly Cys Glu
            1               5                  10

 gaa aaa agg cat gag ggg tcg tct tcg gaa tct gtg cca ccc ggc act       97
 Glu Lys Arg His Glu Gly Ser Ser Ser Glu Ser Val Pro Pro Gly Thr
  15                  20                  25                  30

 acc att tcg agg gtg aag ctc ctc gac acc atg gtg gac act ttt ctt      145
 Thr Ile Ser Arg Val Lys Leu Leu Asp Thr Met Val Asp Thr Phe Leu
                  35                  40                  45

 cag aag ctg gtc gcc gcc ggc agc tac cag aga ttc act gac tgc tat      193
 Gln Lys Leu Val Ala Ala Gly Ser Tyr Gln Arg Phe Thr Asp Cys Tyr
              50                  55                  60

 aag tgc ttc tac cag ttg cag cct gcg atg aca cag caa atc tat gac      241
 Lys Cys Phe Tyr Gln Leu Gln Pro Ala Met Thr Gln Gln Ile Tyr Asp
          65                  70                  75

 aag ttt ata gct cag ttg cag aca tct atc cgg gag gaa atc tct gac      289
 Lys Phe Ile Ala Gln Leu Gln Thr Ser Ile Arg Glu Glu Ile Ser Asp
      80                  85                  90

 atc aaa gag gag ggg aac cta gaa gct gtc ttg aat gcc ttg gat aaa      337
 Ile Lys Glu Glu Gly Asn Leu Glu Ala Val Leu Asn Ala Leu Asp Lys
  95                 100                 105                 110

 att gtg gaa gaa ggc aaa gtc cgc aaa gag cca gcc tgg cgc ccc agc      385
 Ile Val Glu Glu Gly Lys Val Arg Lys Glu Pro Ala Trp Arg Pro Ser
                 115                 120                 125

 ggg atc cca gag aag gat ctg cac agt gtt atg gca ccc tac ttc ctg      433
 Gly Ile Pro Glu Lys Asp Leu His Ser Val Met Ala Pro Tyr Phe Leu
             130                 135                 140

 cag caa cgg gac acc ctg cgg cgc cat gtg cag aaa cag gag gcc gag      481
 Gln Gln Arg Asp Thr Leu Arg Arg His Val Gln Lys Gln Glu Ala Glu
         145                 150                 155

 aac cag cag ctg gca gat gcc gtc ctg gca ggg cgg agg cag gtg gag      529
 Asn Gln Gln Leu Ala Asp Ala Val Leu Ala Gly Arg Arg Gln Val Glu
     160                 165                 170

 gag ctg cag cta cag gtc cag gcc cag cag cag gcc tgg cag gct cta      577
 Glu Leu Gln Leu Gln Val Gln Ala Gln Gln Gln Ala Trp Gln Ala Leu
 175                 180                 185                 190

 cac aga gaa cag agg gag ctg gtt gct gtg ctg agg gag cct gag tga      625
 His Arg Glu Gln Arg Glu Leu Val Ala Val Leu Arg Glu Pro Glu 
                 195                 200                 205

 ggagaccgcc agccccagaa gcagagggca gtcaaggtca agagcctgtg gtccagcatg    685

 cctggcctgg gcgggctacc tctgagaacg gctgaaatgg tgcccagtcc atcagcagtg    745

 atggaatttg ctggaggact aggccagagc aagcctcact gccactgtgc ctttggggca    805

 cccttggggt tggacataca ccccctttag attcctctgt ttcttctacc tggataattc    865

 ttggccatgt tctctcttct ctaggttcag gtcagctctg cccctccgcc cccctcctgc    925

 tggttcccca gcccttttcc ctggccctgg cttggagaat ctgttttcaa tctccactga    985

 ttgccccctt gctggccagc ccaggggcct ttaccatgtt ctctccacat ccgtaaataa   1045

 acttccttca ctacactgta aaaaaaaaaa                                    1075




      <210> 248
      <211> 1145
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (121)..(513)

      <400> 248
 ttgagtagac ttcagtgacc acactgtgga aaataccttt gcagacgtgg cacccgagtg     60

 cacacaccga ccgccacatg tgcttttctg ccgggaatcc ctggggtgaa cgcatgtttt    120
                                                                 
 atg ggc gtt tcc agg agc gcg cgt gca cct cca gac ggg gag ctg gcg      168
 Met Gly Val Ser Arg Ser Ala Arg Ala Pro Pro Asp Gly Glu Leu Ala
   1               5                  10                  15

 ggc ggg ggt ggc agc agc agc tct agc ctt ggg ggg aca agc ctc tct      216
 Gly Gly Gly Gly Ser Ser Ser Ser Ser Leu Gly Gly Thr Ser Leu Ser
              20                  25                  30

 cag cta cgc cag ggg aaa aga gag tta agg aca ctc acc ccc acc cac      264
 Gln Leu Arg Gln Gly Lys Arg Glu Leu Arg Thr Leu Thr Pro Thr His
          35                  40                  45

 gca cac aca caa ggc agc gtc ggg tgg gag aga gaa ggc cgt ttc tcc      312
 Ala His Thr Gln Gly Ser Val Gly Trp Glu Arg Glu Gly Arg Phe Ser
      50                  55                  60

 ttc tgt agc ctg ggt ctc cca cgg gcc ttc ccc gct gct gag cga gac      360
 Phe Cys Ser Leu Gly Leu Pro Arg Ala Phe Pro Ala Ala Glu Arg Asp
  65                  70                  75                  80

 acc agt agc cag gtg aag ggc cac agc ggg cca ggc ccc gac cct gtt      408
 Thr Ser Ser Gln Val Lys Gly His Ser Gly Pro Gly Pro Asp Pro Val
                  85                  90                  95

 gtg acc cac ctg ggc acc ttc ccg gac cag ctc cgc ctc ccc tgc cct      456
 Val Thr His Leu Gly Thr Phe Pro Asp Gln Leu Arg Leu Pro Cys Pro
             100                 105                 110

 cct ctc tcc agg aag gag cca gaa ccc tca ccc ctc tcc cac cct ccc      504
 Pro Leu Ser Arg Lys Glu Pro Glu Pro Ser Pro Leu Ser His Pro Pro
         115                 120                 125

 cag ggg taa ccccagg ccaagcacag atagctcagc tgcgacctct ggcctctggg      560
 Gln Gly 
     130

 gacataaacg gggcggctgg gccagggcgg aaggtgctcc tgtttccctc cttctgcgtg    620

 gtccctttga cgggccggcc accgtgtccg aggcgcaacg ctaggcctcc aggccacgca    680

 tccatctcca agttaacagc ccgtcctgcc caagttctgg ggcaggtagg agagggccgt    740

 cacacacctg tccgcccgtg agtgacccgg gggggcttcc gggtggaggt ggagccacca    800

 cgcccttcct caaggggtca cttattaaaa agtccacggc ctgaggccag gccctctgca    860

 cagaagccat atgccggcca gccgcgcctc ctcctctgtc cacggaaccg ctgcccatct    920

 aaccttcgta aagacctgtc tcctgtttcc agccgccgcc tgtggttcta gcaggttcta    980

 tgccatctgc attgggatgt ctggttgttt ttatttctga cttttttaaa attccaggtg   1040

 tgccgcaccc actttctcgc agtgttttaa tattgtgtgg agttgtcgat accacgtgaa   1100

 ttcatacaca ataaaaagcc tcactctccc tttaaaaaaa aaaaa                   1145




      <210> 249
      <211> 1691
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (543)..(1223)

      <400> 249
 attcagccct ggaggtgcca tcccgggccg cgactccgct ccaggcagga cccccaaccc     60

 gcccagcccg ctccgccttg cgccccggac ccgcggccga ccccagaccc gctgcccgct    120

 tcgcgcccga ggcctgcgcc ccgacggacg cccgtgccca gcttgccacg cccacgcccg    180

 gcgccccgac cgcggaggac tccccgaggt gccggcggag ggggtggctc gcggctcagg    240

 ctgcccccga cgtgcccggc tcaccgcccc ctcccctgca gccccgcccg ccatggcccg    300

 gatcccgacg gccgccctgg gttgcatcag cctcctctgc ctgcagctcc ctggctcgct    360

 gtcccgcagc ctgggcgggg acccgcgacc cgtcaaaccc agggagcccc cagcccggag    420

 cccttccagc agcctgcagc ccaggcaccc cgcaccccga cctgtggtct ggaagcttca    480

 ccgggccctc caggcacaga ggggtgccgg cctggcccct gttatgggtc agcctctccg    540

 gg   atg gtg gcc gcc aac act cgg gcc ccc gca gga ccc aag ccc agc     587
      Met Val Ala Ala Asn Thr Arg Ala Pro Ala Gly Pro Lys Pro Ser
        1               5                  10                  15

 tcc tgc gag tgg gct gcg tgc tgg gca cct gcc agg tgc aga atc tca      635
 Ser Cys Glu Trp Ala Ala Cys Trp Ala Pro Ala Arg Cys Arg Ile Ser
                  20                  25                  30

 gcc acc gcc tgt ggc aac tca tgg gac cgg ccg gcc ggc agg act cag      683
 Ala Thr Ala Cys Gly Asn Ser Trp Asp Arg Pro Ala Gly Arg Thr Gln
              35                  40                  45

 ctc ctg tgg acc cca gca gcc ccc aca gct atg gct gag gtg ggg ccg      731
 Leu Leu Trp Thr Pro Ala Ala Pro Thr Ala Met Ala Glu Val Gly Pro
          50                  55                  60

 ggc cac acc cct gcc cat ccc agc cag ggt gct gtg ccc ccg tcc aga      779
 Gly His Thr Pro Ala His Pro Ser Gln Gly Ala Val Pro Pro Ser Arg
      65                  70                  75

 gct gca gct gag ccc cat ctg aag ccc agt ccc tcg gag ctg cag aca      827
 Ala Ala Ala Glu Pro His Leu Lys Pro Ser Pro Ser Glu Leu Gln Thr
  80                  85                  90                  95

 gca ggt cct gca gca aca ata cct gca cgg ctt tgc aca cgt aaa cct      875
 Ala Gly Pro Ala Ala Thr Ile Pro Ala Arg Leu Cys Thr Arg Lys Pro
                 100                 105                 110

 agg ctg gtc tac acg cag tgc tgg tac gtc aag gag cct aaa cac cct      923
 Arg Leu Val Tyr Thr Gln Cys Trp Tyr Val Lys Glu Pro Lys His Pro
             115                 120                 125

 gaa att gtg acc ccc tgg ggg aca gct gcc aga cac agc tgg cgg cag      971
 Glu Ile Val Thr Pro Trp Gly Thr Ala Ala Arg His Ser Trp Arg Gln
         130                 135                 140

 cac cag atg cta agc gct tca gag agg agg tgt ctg ccc aga gat gtg     1019
 His Gln Met Leu Ser Ala Ser Glu Arg Arg Cys Leu Pro Arg Asp Val
     145                 150                 155

 gag cag aag ctg ggc cct gaa cac acg ggg cca tgt ctg gac gag cag     1067
 Glu Gln Lys Leu Gly Pro Glu His Thr Gly Pro Cys Leu Asp Glu Gln
 160                 165                 170                 175

 ggg aga gag gct gaa ctg gcc aga agt ggc ccc tcc gct gct ggt cca     1115
 Gly Arg Glu Ala Glu Leu Ala Arg Ser Gly Pro Ser Ala Ala Gly Pro
                 180                 185                 190

 gtc aga ctg aag ccc ggc ctt gtg cct ggg ctg ttc ctg ctc tca tgc     1163
 Val Arg Leu Lys Pro Gly Leu Val Pro Gly Leu Phe Leu Leu Ser Cys
             195                 200                 205

 aca acc agc cct tcc acg tgc ctg cct gtg gga cag gag ggg gag cgt     1211
 Thr Thr Ser Pro Ser Thr Cys Leu Pro Val Gly Gln Glu Gly Glu Arg
         210                 215                 220

 ggg atg ctg tag ccc ccggggttgg gcaagggaag gatggtggcc ctccagaggt     1266
 Gly Met Leu 
     225

 catgaaggga cctctgtggc tccagctgcc aaccctggag cccagaccga ggtggccatg   1326

 gagactccac ctggatcccc tgtaggaggc cagggagggg aactcagcag ttcaggagcc   1386

 accccaaacc attctgggac agggacaccc ctttctaccc cagggcaggg cagggctggg   1446

 tggggcaaga tcccccagcc cgactagacc cacctcacct gaagggggtg agacccttgt   1506

 tggcagccag acaagggtgg ggctccacag gcagcacagg cgccccacca ccacccagtt   1566

 tggggaccca gtgggaccag gtgcgggggc agagggtgac ttaccaagag ccagggaggg   1626

 cagcccaggc ccaagtgaca gcaagaacaa gaaccactgc cggcgtgcac agaaaaaaaa   1686

 aaaaa                                                               1691




      <210> 250
      <211> 934
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(649)

      <400> 250
 aaatgaccca ctgtggtcat cttggaagcc tcggccatcc ctgctggctg tgctccattc     60

 ttgtgcctcg ccattggaac gctctagtga gccggaatga agttcaggcc catggctgtg    120

 atgtcacaga acatgtgaag tcagaggtcc t   atg gaa ggt gag ggg aga aaa     172
                                      Met Glu Gly Glu Gly Arg Lys
                                        1               5

 tgc ccc tgg aaa ggg tta agg gcc agg aca gga atg ggg cag gag gtg      220
 Cys Pro Trp Lys Gly Leu Arg Ala Arg Thr Gly Met Gly Gln Glu Val
          10                  15                  20

 cac gga tcc tgc tgg gca ctg gga gca ggg ggc ggc caa agg cag tgg      268
 His Gly Ser Cys Trp Ala Leu Gly Ala Gly Gly Gly Gln Arg Gln Trp
      25                  30                  35

 gtg ggc agg tcc atg cct ccc ctg gcc ccc cag ctc tgc agg gca gtg      316
 Val Gly Arg Ser Met Pro Pro Leu Ala Pro Gln Leu Cys Arg Ala Val
  40                  45                  50                  55

 ttc ctg gtt cct atc ttg ctg ctg ctg cag gtg aag cct ctg aac ggg      364
 Phe Leu Val Pro Ile Leu Leu Leu Leu Gln Val Lys Pro Leu Asn Gly
                  60                  65                  70

 agc cca ggc ccc aaa gat ggg agc cag aca gag aaa acg ccc tct gca      412
 Ser Pro Gly Pro Lys Asp Gly Ser Gln Thr Glu Lys Thr Pro Ser Ala
              75                  80                  85

 gac cag aat caa gaa cag ttc gaa gag cac ttt gtg gcc tcc tca gtg      460
 Asp Gln Asn Gln Glu Gln Phe Glu Glu His Phe Val Ala Ser Ser Val
          90                  95                 100

 ggt gag atg tgg cag gtg gtg gac atg gcc cag cag gaa gaa gac cag      508
 Gly Glu Met Trp Gln Val Val Asp Met Ala Gln Gln Glu Glu Asp Gln
     105                 110                 115

 tcg tcc aag acg gca gct gtt cac aag cac tct ttc cac ctc agc ttc      556
 Ser Ser Lys Thr Ala Ala Val His Lys His Ser Phe His Leu Ser Phe
 120                 125                 130                 135

 tgc ttt agt ctg gcc agt gtc atg gtt ttc tca gga ggg cca ttg agg      604
 Cys Phe Ser Leu Ala Ser Val Met Val Phe Ser Gly Gly Pro Leu Arg
                 140                 145                 150

 cgg aca ttc cca aat atc caa ctc tgc ttc atg ctc act cac tga ccc      652
 Arg Thr Phe Pro Asn Ile Gln Leu Cys Phe Met Leu Thr His 
             155                 160                 165

 tccctccctc ctgggctcca ggtcacaact cccaaaggag atgcaggcat ggctctctgc    712

 ctctgatcac catcactgta tctcaaggtt cagcagcaga gataccagtt gccatcagtg    772

 ctaactgact gcctctccag gttcggagtt tcatctccca gggccagaga cagcagaccc    832

 acatccttct ctcccacacc tctcctggtt ttgttcagga cagcagatta gaggcaggag    892

 gcaatgacaa taaaataacg ataaaatcct gaaaaaaaaa aa                       934




      <210> 251
      <211> 695
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (168)..(425)

      <400> 251
 cggacgcgtg gggaaggttg gctgcagttc cggctacctg tgtagtccga gtttccacag     60

 ccaggtacta ctccgccagt gaccctggac agtaacaaaa catataaagc ccgagcccaa    120

 accccgccac catcataggt ctgtagttac tgtggaatca ataagcc  atg gca tct     176
                                                      Met Ala Ser
                                                        1

 aag aaa ttt gct gtt aaa tgt ggg aat ttt gct gtc ctc gtg gat ctt      224
 Lys Lys Phe Ala Val Lys Cys Gly Asn Phe Ala Val Leu Val Asp Leu
       5                  10                  15

 cat atc ttg cca caa ggt tca aac aaa gat aca agc tgg ttt tct gaa      272
 His Ile Leu Pro Gln Gly Ser Asn Lys Asp Thr Ser Trp Phe Ser Glu
  20                  25                  30                  35

 cag aag aaa gag gaa gtc tgt tta ctg tta aaa gaa acc att gat tca      320
 Gln Lys Lys Glu Glu Val Cys Leu Leu Leu Lys Glu Thr Ile Asp Ser
                  40                  45                  50

 aga gtt cag gag tac ttg gaa gtt cgc aaa cag cac agg cca tca aat      368
 Arg Val Gln Glu Tyr Leu Glu Val Arg Lys Gln His Arg Pro Ser Asn
              55                  60                  65

 gca gaa ttc aca aga tcc aat ccc ttg tcc tta aaa ggt agg cac aga      416
 Ala Glu Phe Thr Arg Ser Asn Pro Leu Ser Leu Lys Gly Arg His Arg
          70                  75                  80

 gca ctt tga ttttgga caaaaaataa atagaatttc tgctccgtag agatggcaat      472
 Ala Leu 
      85

 tatgtttgac tctgactgtc atgttagtat agtgatacat tttaaaaata tgtcctaatg    532

 aagatacttt gtttgggtaa agaaaattaa ctgaagagcc ctcaggactt ttaatggtag    592

 gcaaaatgta taaaaatagc aaataaaaca ttcctaagga aactgtaaat tgtttaaagg    652

 attgtttttt atttttaagg tttttttatt tttagtagac tta                      695




      <210> 252
      <211> 567
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (120)..(314)

      <400> 252
 aacaagccac ctgccttccc tgagactgtc tcttctcctg tgaaattagg gcattagaat     60

 acatgaagac ccctttatgt ccttaataac ctgtaagttt aagaacctag ggaatctcc     119                                                                 
 atg ctg gtg gct gcg gtt ata tcc cct tat cct caa ctc gtg aag aaa      167
 Met Leu Val Ala Ala Val Ile Ser Pro Tyr Pro Gln Leu Val Lys Lys
   1               5                  10                  15

 gag tca aaa atg gca gca ggg ttg tgt caa ctg ctc tcc tca gca gct      215
 Glu Ser Lys Met Ala Ala Gly Leu Cys Gln Leu Leu Ser Ser Ala Ala
              20                  25                  30

 atc ata agg gaa ttg cct ttg tca ttt tcc cca gcc atc acc aca ctc      263
 Ile Ile Arg Glu Leu Pro Leu Ser Phe Ser Pro Ala Ile Thr Thr Leu
          35                  40                  45

 cca cac ggc cac cat cac cta aac cat ctg gca ggg ggg gtt acc tcc      311
 Pro His Gly His His His Leu Asn His Leu Ala Gly Gly Val Thr Ser
      50                  55                  60

 taa atct aagacgcaga gacccaccgc aggcctttct ttctggctgc cctccactcc      368
 


 cacccagagg ctcagttttg ctgggctgca cacctccgag gactcagttc tttgtgtttc    428

 atggtgttcc atatccacta gagttacaga aactgctgca aaccaaggac caaaagtcca    488

 taggttctaa ttctagctgt gacactagcg agatgagtga ctgctggcaa ggtactttat    548

 ctattctgac ctcacctcg                                                 567




      <210> 253
      <211> 420
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (90)..(230)

      <400> 253
 aacgaaagac cctgaactag agtcccaggt caacctctct gtctcggaag acctaggctg     60

 tagacgtggg gatttcagta ggaaacatt  atg gat ctg tgg agc tgc tta ttt     113
                                  Met Asp Leu Trp Ser Cys Leu Phe
                                    1               5

 cca gtg atg ctg atg gag cca tcc aaa ggg ctg gaa gat tca gag tgg      161
 Pro Val Met Leu Met Glu Pro Ser Lys Gly Leu Glu Asp Ser Glu Trp
      10                  15                  20

 aaa atg gct ctt cag atg aga atg caa ctg ccc tgc ctg gta ctt ggc      209
 Lys Met Ala Leu Gln Met Arg Met Gln Leu Pro Cys Leu Val Leu Gly
  25                  30                  35                  40

 gaa gaa cag acg tgc act tag ag aacccagaat accacaccag atggtatttc      262
 Glu Glu Gln Thr Cys Thr 
                  45

 aaatattttt taggacaagt ccatcagaac tacattggaa acgatgccga gaagagccct    322

 ttcttcttgt ccgtgaccct ttctgaccaa aacaatcaac gtgtccctca ataccgtgca    382

 attctttgga gaaaaacagg tacccagaaa atatgccg                            420




      <210> 254
      <211> 3317
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (187)..(3078)

      <400> 254
 aaatcagtcc gtacagtggc gaggcagtcg agcaacagga agcggtcgct ctttccccaa     60

 atcccactgc cttgtgggat ctcggcaagt catccaccca ccccccgcgc ctacgcaagt    120

 tttccggatc cgtccacccc cgcctccctc ctagtgtacg gaagctgaga gggcccgcgg    180

 gtaggc   atg gcg gcg cac ctt aag aag cgg gtt tat gag gaa ttc acg     228
          Met Ala Ala His Leu Lys Lys Arg Val Tyr Glu Glu Phe Thr
            1               5                  10

 aaa gtg gtt cag cca cag gag gaa att gct act aag aaa ctc cga cta      276
 Lys Val Val Gln Pro Gln Glu Glu Ile Ala Thr Lys Lys Leu Arg Leu
  15                  20                  25                  30

 aca aaa cca agt aaa tct gca gca ctc cac ata gat ctg tgt aaa gct      324
 Thr Lys Pro Ser Lys Ser Ala Ala Leu His Ile Asp Leu Cys Lys Ala
                  35                  40                  45

 acc tcc cca gca gat gct ttg caa tac ttg ctc cag ttt gcc agg aag      372
 Thr Ser Pro Ala Asp Ala Leu Gln Tyr Leu Leu Gln Phe Ala Arg Lys
              50                  55                  60

 cct gtc gag gcg gaa agc gta gag gga gta gtc agg att ctc ttg gaa      420
 Pro Val Glu Ala Glu Ser Val Glu Gly Val Val Arg Ile Leu Leu Glu
          65                  70                  75

 cat tat tac aag gag aat gat cca tct gtg aga ctg aaa att gca tca      468
 His Tyr Tyr Lys Glu Asn Asp Pro Ser Val Arg Leu Lys Ile Ala Ser
      80                  85                  90

 ttg ttg ggt tta tta tca aag aca gca gga ttt tca cca gac tgc att      516
 Leu Leu Gly Leu Leu Ser Lys Thr Ala Gly Phe Ser Pro Asp Cys Ile
  95                 100                 105                 110

 atg gat gat gcc atc aac atc ctg cag aat gaa aag tct cat caa gtc      564
 Met Asp Asp Ala Ile Asn Ile Leu Gln Asn Glu Lys Ser His Gln Val
                 115                 120                 125

 cta gct caa ctg ctg gat act ttg ctt gca att ggc act aag cta cca      612
 Leu Ala Gln Leu Leu Asp Thr Leu Leu Ala Ile Gly Thr Lys Leu Pro
             130                 135                 140

 gag aat caa gct atc caa atg cga tta gtt gat gtg gcc tgc aag cat      660
 Glu Asn Gln Ala Ile Gln Met Arg Leu Val Asp Val Ala Cys Lys His
         145                 150                 155

 ctg aca gat acg tct cat ggt gta aga aat aag tgc ctg cag tta ctt      708
 Leu Thr Asp Thr Ser His Gly Val Arg Asn Lys Cys Leu Gln Leu Leu
     160                 165                 170

 ggc aat ctt ggc tct ttg gag aaa agt gtc aca aaa gat gca gaa ggc      756
 Gly Asn Leu Gly Ser Leu Glu Lys Ser Val Thr Lys Asp Ala Glu Gly
 175                 180                 185                 190

 cta gct gcc aga gat gtc cag aag att ata ggg gat tac ttc agt gac      804
 Leu Ala Ala Arg Asp Val Gln Lys Ile Ile Gly Asp Tyr Phe Ser Asp
                 195                 200                 205

 caa gac cca cgt gtc aga aca gca gct ata aaa gcc atg ttg cag ctc      852
 Gln Asp Pro Arg Val Arg Thr Ala Ala Ile Lys Ala Met Leu Gln Leu
             210                 215                 220

 cat gaa aga gga ctg aaa tta cac caa aca att tat aat cag gcc tgt      900
 His Glu Arg Gly Leu Lys Leu His Gln Thr Ile Tyr Asn Gln Ala Cys
         225                 230                 235

 aaa tta ctc tct gat gac tat gaa caa gtg cgc agt gct gca gtc cag      948
 Lys Leu Leu Ser Asp Asp Tyr Glu Gln Val Arg Ser Ala Ala Val Gln
     240                 245                 250

 ctt atc tgg gtc gtc agt cag ctc tat cct gaa agc att gtc cca att      996
 Leu Ile Trp Val Val Ser Gln Leu Tyr Pro Glu Ser Ile Val Pro Ile
 255                 260                 265                 270

 cct tct tct aat gaa gaa ata cgc tta gtt gat gat gcg ttt ggc aaa     1044
 Pro Ser Ser Asn Glu Glu Ile Arg Leu Val Asp Asp Ala Phe Gly Lys
                 275                 280                 285

 att tgt cac atg gtc agt gat ggc tct tgg gtg gtt cgt gtt cag gca     1092
 Ile Cys His Met Val Ser Asp Gly Ser Trp Val Val Arg Val Gln Ala
             290                 295                 300

 gca aaa ctg ttg ggc tct atg gag caa gtc agt tct cat ttc ttg gag     1140
 Ala Lys Leu Leu Gly Ser Met Glu Gln Val Ser Ser His Phe Leu Glu
         305                 310                 315

 cag acc ctt gac aag aag ctg atg tca gat ctg agg agg aaa cgt act     1188
 Gln Thr Leu Asp Lys Lys Leu Met Ser Asp Leu Arg Arg Lys Arg Thr
     320                 325                 330

 gca cat gag cgt gcc aag gaa ctt tac agt tcg ggg gag ttt tcc agt     1236
 Ala His Glu Arg Ala Lys Glu Leu Tyr Ser Ser Gly Glu Phe Ser Ser
 335                 340                 345                 350

 ggc aga aag tgg gga gat gat gct ccc aag gaa gaa gta gat acc ggg     1284
 Gly Arg Lys Trp Gly Asp Asp Ala Pro Lys Glu Glu Val Asp Thr Gly
                 355                 360                 365

 gct gtg aac ttg att gag tca gga gct tgt gga gct ttt gtt cat ggg     1332
 Ala Val Asn Leu Ile Glu Ser Gly Ala Cys Gly Ala Phe Val His Gly
             370                 375                 380

 ttg gaa gat gag atg tat gag gtt cgt att gct gct gtg gag gcc ctc     1380
 Leu Glu Asp Glu Met Tyr Glu Val Arg Ile Ala Ala Val Glu Ala Leu
         385                 390                 395

 tgc atg ttg gcc cag tct tca ccc tct ttt gct gag aag tgc ctt gat     1428
 Cys Met Leu Ala Gln Ser Ser Pro Ser Phe Ala Glu Lys Cys Leu Asp
     400                 405                 410

 ttc cta gtt gac atg ttc aac gat gaa att gag gaa gta cgt ctg cag     1476
 Phe Leu Val Asp Met Phe Asn Asp Glu Ile Glu Glu Val Arg Leu Gln
 415                 420                 425                 430

 tct ata cat acc atg aga aaa atc tct aac aac atc acc ctc cga gaa     1524
 Ser Ile His Thr Met Arg Lys Ile Ser Asn Asn Ile Thr Leu Arg Glu
                 435                 440                 445

 gat cag ctt gac act gtc ctg gct gtg cta gag gat tca tcc aga gat     1572
 Asp Gln Leu Asp Thr Val Leu Ala Val Leu Glu Asp Ser Ser Arg Asp
             450                 455                 460

 att cga gag gct ctt cat gaa ctc tta tgc tgt act aat gtt tca acc     1620
 Ile Arg Glu Ala Leu His Glu Leu Leu Cys Cys Thr Asn Val Ser Thr
         465                 470                 475

 aaa gaa ggg att cat ctt gca ttg gtg gag ctg ctg aaa aat tta acc     1668
 Lys Glu Gly Ile His Leu Ala Leu Val Glu Leu Leu Lys Asn Leu Thr
     480                 485                 490

 aag tac cct act gat agg gac tcc ata tgg aag tgc ttg aag ttt ctg     1716
 Lys Tyr Pro Thr Asp Arg Asp Ser Ile Trp Lys Cys Leu Lys Phe Leu
 495                 500                 505                 510

 gga agt cgg cat cca acc ctg gtg ctt ccc ttg gtg cca gag ctt ctg     1764
 Gly Ser Arg His Pro Thr Leu Val Leu Pro Leu Val Pro Glu Leu Leu
                 515                 520                 525

 agc acc cac cca ttt ttt gac aca gct gaa cca gac atg gat gat cca     1812
 Ser Thr His Pro Phe Phe Asp Thr Ala Glu Pro Asp Met Asp Asp Pro
             530                 535                 540

 gct tat att gca gtt ttg gta ctt att ttc aat gct gct aaa acc tgt     1860
 Ala Tyr Ile Ala Val Leu Val Leu Ile Phe Asn Ala Ala Lys Thr Cys
         545                 550                 555

 cca aca atg cca gca ttg ttc tca gat cac acc ttc agg cac tat gcc     1908
 Pro Thr Met Pro Ala Leu Phe Ser Asp His Thr Phe Arg His Tyr Ala
     560                 565                 570

 tac ctc cga gac agt ctt tct cat ctt gtt cct gcc ttg agg tta cca     1956
 Tyr Leu Arg Asp Ser Leu Ser His Leu Val Pro Ala Leu Arg Leu Pro
 575                 580                 585                 590

 ggt aga aaa ctg gtg tca tca gct gtt tct ccc agc atc ata cct caa     2004
 Gly Arg Lys Leu Val Ser Ser Ala Val Ser Pro Ser Ile Ile Pro Gln
                 595                 600                 605

 gag gat cct tcc cag cag ttc ctg cag cag agc ctt gaa aga gtg tat     2052
 Glu Asp Pro Ser Gln Gln Phe Leu Gln Gln Ser Leu Glu Arg Val Tyr
             610                 615                 620

 agt ctt cag cac ttg gac cct cag gga gcc cag gag ctg ctg gaa ttc     2100
 Ser Leu Gln His Leu Asp Pro Gln Gly Ala Gln Glu Leu Leu Glu Phe
         625                 630                 635

 acc atc agg gat ctg caa aga ctt gga gaa ctt caa tct gaa ttg gca     2148
 Thr Ile Arg Asp Leu Gln Arg Leu Gly Glu Leu Gln Ser Glu Leu Ala
     640                 645                 650

 gga gta gct gat ttc tct gcc acc tat ctt cgc tgt caa cta ctt ctc     2196
 Gly Val Ala Asp Phe Ser Ala Thr Tyr Leu Arg Cys Gln Leu Leu Leu
 655                 660                 665                 670

 atc aag gcc ttg cag gaa aag ttg tgg aat gta gct gcc cct ttg tat     2244
 Ile Lys Ala Leu Gln Glu Lys Leu Trp Asn Val Ala Ala Pro Leu Tyr
                 675                 680                 685

 ttg aag cag agt gat ttg gcc tca gca gca gcg aaa cag att atg gaa     2292
 Leu Lys Gln Ser Asp Leu Ala Ser Ala Ala Ala Lys Gln Ile Met Glu
             690                 695                 700

 gag acc tac aaa atg gaa ttc atg tac agt ggt gtg gag aat aag cag     2340
 Glu Thr Tyr Lys Met Glu Phe Met Tyr Ser Gly Val Glu Asn Lys Gln
         705                 710                 715

 gtg gtg att ata cat cac atg agg ctg cag gcc aaa gct ttg caa ctt     2388
 Val Val Ile Ile His His Met Arg Leu Gln Ala Lys Ala Leu Gln Leu
     720                 725                 730

 ata gta aca gca cga act aca cga gga ctt gac ccc tta ttt ggg atg     2436
 Ile Val Thr Ala Arg Thr Thr Arg Gly Leu Asp Pro Leu Phe Gly Met
 735                 740                 745                 750

 tgt gaa aaa ttt tta cag gaa gta gac ttt ttt cag agg tat ttc atc     2484
 Cys Glu Lys Phe Leu Gln Glu Val Asp Phe Phe Gln Arg Tyr Phe Ile
                 755                 760                 765

 gct gat ttg ccc cac ttg cag gac agc ttt gtg gac aaa ctc ctt gac     2532
 Ala Asp Leu Pro His Leu Gln Asp Ser Phe Val Asp Lys Leu Leu Asp
             770                 775                 780

 ctt atg ccc cga ctc atg aca tcc aaa cct gca gaa gtg gtc aaa att     2580
 Leu Met Pro Arg Leu Met Thr Ser Lys Pro Ala Glu Val Val Lys Ile
         785                 790                 795

 cta cag acc atg ctg cga cag agt gcc ttt ctg cat ctc ccg ctt cca     2628
 Leu Gln Thr Met Leu Arg Gln Ser Ala Phe Leu His Leu Pro Leu Pro
     800                 805                 810

 gag cag atc cac aaa gcc tca gcc acc atc atc gag cca gcg ggc gag     2676
 Glu Gln Ile His Lys Ala Ser Ala Thr Ile Ile Glu Pro Ala Gly Glu
 815                 820                 825                 830

 tca gac aac cct ttg cgg ttt acc tct ggg ttg gtg gtt gcc ctg gat     2724
 Ser Asp Asn Pro Leu Arg Phe Thr Ser Gly Leu Val Val Ala Leu Asp
                 835                 840                 845

 gtt gat gca acc ctg gag cat gtg cag gat cct cag aac act gtt aag     2772
 Val Asp Ala Thr Leu Glu His Val Gln Asp Pro Gln Asn Thr Val Lys
             850                 855                 860

 gtc cag gtc tta tat cca gat ggc cag gct cag atg att cac ccc aag     2820
 Val Gln Val Leu Tyr Pro Asp Gly Gln Ala Gln Met Ile His Pro Lys
         865                 870                 875

 cct gca gac ttc cgg aat cct ggc cca ggg cgg cac cgg ctc atc act     2868
 Pro Ala Asp Phe Arg Asn Pro Gly Pro Gly Arg His Arg Leu Ile Thr
     880                 885                 890

 cag gtt tat ctc tcc cac acc gct tgg aca gag gca tgc cag gtg gaa     2916
 Gln Val Tyr Leu Ser His Thr Ala Trp Thr Glu Ala Cys Gln Val Glu
 895                 900                 905                 910

 gtg agg ctg ctg ctg gcc tac aac tcc agt gct cgc att cca aaa tgc     2964
 Val Arg Leu Leu Leu Ala Tyr Asn Ser Ser Ala Arg Ile Pro Lys Cys
                 915                 920                 925

 ccc tgg atg gag ggt ggt gag atg tca cca cag gtg gaa acc agc atc     3012
 Pro Trp Met Glu Gly Gly Glu Met Ser Pro Gln Val Glu Thr Ser Ile
             930                 935                 940

 gag ggc acc att ccc ttc agc aag cct gta aaa gtt tat ata atg ccc     3060
 Glu Gly Thr Ile Pro Phe Ser Lys Pro Val Lys Val Tyr Ile Met Pro
         945                 950                 955

 aaa cct gca cgg cgc taa ggcaaa aacagtcttc ccaaccgtgg cctagagggc     3114
 Lys Pro Ala Arg Arg 
     960

 ccttcttagg tgtcagaatg agccaagcct gaagcacttc acctggaatt gatgtgtagg   3174

 cttaaggagt atgtgaccct tacagtctca tctggtatca aacacaggat aaattgtttc   3234

 ttcattaaaa aataaaaaac cttcaagtct acttaccctt ctcctgtcca caataaagtt   3294

 gagaaaacac caaaaaaaaa aaa                                           3317




      <210> 255
      <211> 611
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (135)..(560)

      <400> 255
 agcaataaag aagttgtaat ttttacctag acaaacagag aactggtttt gacagtgttt     60

 ctagagggct ttttattatt ttcctgacag ttgtgttcca ccatgattac tttctccttc    120

 agcgaatagg ctaa  atg aat atg aaa cag aaa agc gtg tat cag caa acc     170
                  Met Asn Met Lys Gln Lys Ser Val Tyr Gln Gln Thr
                    1               5                  10

 aaa gca ctt ctg tgc aag aat ttt ctt aag aaa tgg agg atg aaa aga      218
 Lys Ala Leu Leu Cys Lys Asn Phe Leu Lys Lys Trp Arg Met Lys Arg
          15                  20                  25

 gag agc tta ttg gaa tgg ggc ctc tca ata ctt cta gga ctg tgt att      266
 Glu Ser Leu Leu Glu Trp Gly Leu Ser Ile Leu Leu Gly Leu Cys Ile
      30                  35                  40

 gct ctg ttt tcc agt tcc atg aga aat gtc cag ttt cct gga atg gct      314
 Ala Leu Phe Ser Ser Ser Met Arg Asn Val Gln Phe Pro Gly Met Ala
  45                  50                  55                  60

 cct cag aat ctg gga agg gta gat aaa ttt aat agc tct tct tta atg      362
 Pro Gln Asn Leu Gly Arg Val Asp Lys Phe Asn Ser Ser Ser Leu Met
                  65                  70                  75

 gtt gtg tat aca cca ata tct aat tta acc cag cag ata atg aat aaa      410
 Val Val Tyr Thr Pro Ile Ser Asn Leu Thr Gln Gln Ile Met Asn Lys
              80                  85                  90

 aca gca ctt gct cct ctt ttg aaa gga aca agt gtc att ggg gca cca      458
 Thr Ala Leu Ala Pro Leu Leu Lys Gly Thr Ser Val Ile Gly Ala Pro
          95                 100                 105

 aat aaa aca cac atg gac gaa ata ctt ctg gaa aat tta cca tat gct      506
 Asn Lys Thr His Met Asp Glu Ile Leu Leu Glu Asn Leu Pro Tyr Ala
     110                 115                 120

 atg gga atc atc ttt aat gaa act ttc tct tat aag tta ata ttt ttc      554
 Met Gly Ile Ile Phe Asn Glu Thr Phe Ser Tyr Lys Leu Ile Phe Phe
 125                 130                 135                 140

 cag tga tataacagtc cactttggaa agaagatttc tcaggtgact ttccatatca       610
 Gln 


 a                                                                    611




      <210> 256
      <211> 831
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (154)..(831)

      <400> 256
 attgttagag acctgtcatt gatagcagtt gctagttgct gccttttaag agctcgttga     60

 ttcctctgca aggtggtgca gcatcctctg tcccttcatt catttcagat ctactcaggt    120

 ctccctgtaa acagatctct cggatcaata agc atg aat gac gaa gac tac agc     174
                                      Met Asn Asp Glu Asp Tyr Ser
                                        1               5

 acc atc tat gac aca atc caa aat gag agg acg tat gag gtt cca gac      222
 Thr Ile Tyr Asp Thr Ile Gln Asn Glu Arg Thr Tyr Glu Val Pro Asp
          10                  15                  20

 cag cca gaa gaa aat gaa agt ccc cat tat gat gat gtc cat gag tac      270
 Gln Pro Glu Glu Asn Glu Ser Pro His Tyr Asp Asp Val His Glu Tyr
      25                  30                  35

 tta agg cca gaa aat gat tta tat gcc act cag ctg aat acc cat gag      318
 Leu Arg Pro Glu Asn Asp Leu Tyr Ala Thr Gln Leu Asn Thr His Glu
  40                  45                  50                  55

 tat gat ttt gtg tca gtc tat acc att aag ggt gaa gag acc agc ttg      366
 Tyr Asp Phe Val Ser Val Tyr Thr Ile Lys Gly Glu Glu Thr Ser Leu
                  60                  65                  70

 gcc tct gtc cag tca gaa gac aga ggc tac ctc ctg cct gat gag ata      414
 Ala Ser Val Gln Ser Glu Asp Arg Gly Tyr Leu Leu Pro Asp Glu Ile
              75                  80                  85

 tac tct gaa ctc cag gag gct cat cca ggt gag ccc cag gag gac agg      462
 Tyr Ser Glu Leu Gln Glu Ala His Pro Gly Glu Pro Gln Glu Asp Arg
          90                  95                 100

 ggc atc tca atg gaa ggg tta tat tca tca acc cag gac cag caa ctc      510
 Gly Ile Ser Met Glu Gly Leu Tyr Ser Ser Thr Gln Asp Gln Gln Leu
     105                 110                 115

 tgc gca gca gaa ctc cag gag aat ggg agt gtg atg aag gaa gat ctg      558
 Cys Ala Ala Glu Leu Gln Glu Asn Gly Ser Val Met Lys Glu Asp Leu
 120                 125                 130                 135

 cct tct cct tca agc ttc acc att cag cac agt aag gcc ttc tct acc      606
 Pro Ser Pro Ser Ser Phe Thr Ile Gln His Ser Lys Ala Phe Ser Thr
                 140                 145                 150

 acc aag tat tcc tgc tat tct gat gct gaa ggt ttg gaa gaa aag gag      654
 Thr Lys Tyr Ser Cys Tyr Ser Asp Ala Glu Gly Leu Glu Glu Lys Glu
             155                 160                 165

 gga gct cac atg aac cct gag att tac ctc ttt gtg aag gga aag ccc      702
 Gly Ala His Met Asn Pro Glu Ile Tyr Leu Phe Val Lys Gly Lys Pro
         170                 175                 180

 aag cat ttt gct gaa gaa ttt gat gtg ggt gaa aag aaa aat aaa gag      750
 Lys His Phe Ala Glu Glu Phe Asp Val Gly Glu Lys Lys Asn Lys Glu
     185                 190                 195

 cca tgg ttg act cta gag att ata gtg agc tat gga ccc ctt ctc aga      798
 Pro Trp Leu Thr Leu Glu Ile Ile Val Ser Tyr Gly Pro Leu Leu Arg
 200                 205                 210                 215

 aaa tgt gcg aat gag aaa gct gat att cgc taa                          831
 Lys Cys Ala Asn Glu Lys Ala Asp Ile Arg 
                 220                 225





      <210> 257
      <211> 2457
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (153)..(650)

      <400> 257
 cccacgcgtc cgcccacgcg tccgcgagat cttctctgtg gcggagacag ccaggttggc     60

 agctgacggg acagccgggg tctattttgt tgcgggtttt cagcaaatcc agggctggtc    120

 tggaggcgcg aaaacttaag gcatacagaa cg  atg gag tat atg gca gaa tcc     173
                                      Met Glu Tyr Met Ala Glu Ser
                                        1               5

 acc gac cgc agc cct gga cac atc ttg tgc tgt gag tgt ggt gtt ccg      221
 Thr Asp Arg Ser Pro Gly His Ile Leu Cys Cys Glu Cys Gly Val Pro
          10                  15                  20

 ata agt cca aat cct gcc aat att tgt gtg gcc tgt ttg cga agt aaa      269
 Ile Ser Pro Asn Pro Ala Asn Ile Cys Val Ala Cys Leu Arg Ser Lys
      25                  30                  35

 gtg gac atc agc caa ggt att ccg aaa caa gtc tcg att tcg ttc tgc      317
 Val Asp Ile Ser Gln Gly Ile Pro Lys Gln Val Ser Ile Ser Phe Cys
  40                  45                  50                  55

 aaa caa tgt caa agg tat ttt caa cca cca gga act tgg ata cag tgt      365
 Lys Gln Cys Gln Arg Tyr Phe Gln Pro Pro Gly Thr Trp Ile Gln Cys
                  60                  65                  70

 gct tta gaa tcc agg gaa ctt ctt gct ttg tgc ttg aaa aaa atc aaa      413
 Ala Leu Glu Ser Arg Glu Leu Leu Ala Leu Cys Leu Lys Lys Ile Lys
              75                  80                  85

 gcc cct ctg agt aag gta cgg ctt gta gat gca ggc ttt gtt tgg act      461
 Ala Pro Leu Ser Lys Val Arg Leu Val Asp Ala Gly Phe Val Trp Thr
          90                  95                 100

 gag cct cat tct aag aga ctt aaa gtt aaa ctg act att cag aaa gag      509
 Glu Pro His Ser Lys Arg Leu Lys Val Lys Leu Thr Ile Gln Lys Glu
     105                 110                 115

 gtg atg aat ggt gct atc ctt caa caa gtg ttt gtg gtg gat tat gtt      557
 Val Met Asn Gly Ala Ile Leu Gln Gln Val Phe Val Val Asp Tyr Val
 120                 125                 130                 135

 gtt cag tcc caa atg tgt gga gat tgc cat aga gta gaa gct aag gat      605
 Val Gln Ser Gln Met Cys Gly Asp Cys His Arg Val Glu Ala Lys Asp
                 140                 145                 150

 ttc tgg aaa ggc tgt gat tca agt gag gca aaa gac ttt gca taa aaa      653
 Phe Trp Lys Gly Cys Asp Ser Ser Glu Ala Lys Asp Phe Ala 
             155                 160                 165

 aactttctac tatctggaac agttaattct gaaatatgga atgcatcaga atacacttcg    713

 tatcaaagag attcatgatg gtctggattt ttattattcc tcaaaacaac atgctcagaa    773

 gatggtcgaa tttcttcagt gtacagttcc ctgtagatac aaagcatcac aaagactgat    833

 ctctcaagat atccatagta acacatacaa ttacaaaagc actttttctg tggaaattgt    893

 tccaatatgc aaggataatg ttgtctgtct gtctccaaaa ctggcacaaa gcctgggaaa    953

 tatgaaccag atttgtgtgt gtattcgagt aaccagtgcc attcacctca ttgatccaaa   1013

 caccctacaa gtggcagata ttgatgggag cactttctgg agtcaccctt tcaatagttt   1073

 atgtcatccc aaacagctag aggagtttat tgtgatggaa tgcagcatag tccaagatat   1133

 aaaacgtgct gcaggtgctg gaatgatatc aaaaaagcat accctcgggg aagtctgggt   1193

 acagaagaca tctgaaatga atacagataa acagtatttt tgtcgtactc atttgggaca   1253

 tcttctaaat cccggagacc tggtgttagg gtttgatttg gccaactgta acttaaatga   1313

 tgagcatgtc aacaaaatga actcagatag agttccagat gtggtattaa tcaagaagag   1373

 ctatgaccgg accaaacgtc agcgtcgtag aaactggaaa ttgaaagagc ttgcaagaga   1433

 gagagaaaac atggatacag atgatgaaag gcaataccaa gattttcttg aagatcttga   1493

 agaagatgag gcaattcgaa aaaatgtcaa catttacaga gattcagcca tccctgtgga   1553

 aagtgacacc gatgatgaag gagcacctcg aattagtctg gctgagatgc ttgaagacct   1613

 tcatatttcc caagatgcca ctggtgaaga aggtgcatca atgctgacat aatgagatgt   1673

 tgtagactgt ttccatacat gggcttaaga agttggacag agttacctta agtgtctcta   1733

 ctatctttgc ctccagattt caagaggaga aatttagttt taaacctgaa taaacatgtt   1793

 tgttttcagt gctcactcaa accactaaaa cagatggata gctttgaggt tttagataag   1853

 gaaagattat ggagaatgta gttgttactg atttttgggc aattttacat ttgggaattt   1913

 tatccactgt ggctttttta tatgaggcac tgtagtattt tccacatagt atagtactct   1973

 gggatgttaa aagctcaaaa attgtgattc cttgaacgtt cactaaatct tcaagcaaaa   2033

 acacattttt acattatttt tacgttgatt attttagtga aagaccatat gaagaagcat   2093

 ttttaatatt aacttgttac atactttgat ccactttaca tcatttttat gttgttgagg   2153

 tagggaaatt agggttcagt ttattgaaca gatcaccatt aaaaagaata ttagaatcca   2213

 gcatgaagat aatggctaat aaaaatgagg tacatacttt ataaaaccat taatcagatt   2273

 tgaatgagga atgcttccca catccttgaa agaaaaactg tggcttacgt tttgaagtat   2333

 tctgagaatg aagtattaag atccaatttc tataagcaag atcagacttg ttaagtatgc   2393

 cgcaagtaag agctaattca ttcattccat gtgtgccact aaataaagag attgagcaag   2453

 tgcc                                                                2457




      <210> 258
      <211> 1202
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (81)..(1202)

      <400> 258
 gccggtgcgc gggcgaaacc gcactacctg tctgcgggaa agcgggatcc accccaggac     60

 gtcgggtcgc tgccgacata    atg tca agt gga aac tat cag cag tca gag     110
                          Met Ser Ser Gly Asn Tyr Gln Gln Ser Glu
                            1               5                  10

 gct ctt agc aaa ccc act ttc agt gag gaa caa gcc tct gcg tta gtg      158
 Ala Leu Ser Lys Pro Thr Phe Ser Glu Glu Gln Ala Ser Ala Leu Val
                  15                  20                  25

 gag tca gtg ttt ggg ttg aaa gtt tcc aag gtc cgg cca ctt cct agc      206
 Glu Ser Val Phe Gly Leu Lys Val Ser Lys Val Arg Pro Leu Pro Ser
              30                  35                  40

 tat gat gac caa aac ttt cat gtc tac gtt tca aaa acc aaa gat ggc      254
 Tyr Asp Asp Gln Asn Phe His Val Tyr Val Ser Lys Thr Lys Asp Gly
          45                  50                  55

 cca act gaa tat gtc ctc aaa ata agc aac acc aag gct agc aaa aat      302
 Pro Thr Glu Tyr Val Leu Lys Ile Ser Asn Thr Lys Ala Ser Lys Asn
      60                  65                  70

 cca gac ctg att gaa gtg cag aat cac atc atc atg ttt ctg aaa gcc      350
 Pro Asp Leu Ile Glu Val Gln Asn His Ile Ile Met Phe Leu Lys Ala
  75                  80                  85                  90

 gct gga ttt cca aca gcc tct gtg tgt cac act aaa gga gac aac aca      398
 Ala Gly Phe Pro Thr Ala Ser Val Cys His Thr Lys Gly Asp Asn Thr
                  95                 100                 105

 gct tct ctc gtg tct gta gat agt ggc tct gaa atc aaa agc tac ttg      446
 Ala Ser Leu Val Ser Val Asp Ser Gly Ser Glu Ile Lys Ser Tyr Leu
             110                 115                 120

 gtg agg ctg ctg act tac ctc cca gga aga ccc atc gct gag ctt ccc      494
 Val Arg Leu Leu Thr Tyr Leu Pro Gly Arg Pro Ile Ala Glu Leu Pro
         125                 130                 135

 gtc agc ccc cag cta ttg tat gaa att gga aaa cta gct gcc aaa ttg      542
 Val Ser Pro Gln Leu Leu Tyr Glu Ile Gly Lys Leu Ala Ala Lys Leu
     140                 145                 150

 gat aag aca ctg cag aga ttc cat cac cca aag tta agt agt ctt cat      590
 Asp Lys Thr Leu Gln Arg Phe His His Pro Lys Leu Ser Ser Leu His
 155                 160                 165                 170

 cgg gag aac ttc atc tgg aat ctg aaa aat gtt cct ctt ctg gag aaa      638
 Arg Glu Asn Phe Ile Trp Asn Leu Lys Asn Val Pro Leu Leu Glu Lys
                 175                 180                 185

 tac ctg tat gcc ctg ggc cag aat cga aac cga gag att gtt gag cat      686
 Tyr Leu Tyr Ala Leu Gly Gln Asn Arg Asn Arg Glu Ile Val Glu His
             190                 195                 200

 gtc att cat ctg ttc aag gag gaa gta atg acc aaa tta agt cat ttt      734
 Val Ile His Leu Phe Lys Glu Glu Val Met Thr Lys Leu Ser His Phe
         205                 210                 215

 cga gaa tgt atc aat cac gga gat ctt aat gac cat aat att tta ata      782
 Arg Glu Cys Ile Asn His Gly Asp Leu Asn Asp His Asn Ile Leu Ile
     220                 225                 230

 gag tcc agc aag tca gcc tct gga aat gct gaa tat caa gtg tct ggg      830
 Glu Ser Ser Lys Ser Ala Ser Gly Asn Ala Glu Tyr Gln Val Ser Gly
 235                 240                 245                 250

 att tta gac ttt ggt gac atg agc tat ggc tac tat gtg ttt gaa gtg      878
 Ile Leu Asp Phe Gly Asp Met Ser Tyr Gly Tyr Tyr Val Phe Glu Val
                 255                 260                 265

 gca att acc atc atg tac atg atg att gag agc aag agt cct ata caa      926
 Ala Ile Thr Ile Met Tyr Met Met Ile Glu Ser Lys Ser Pro Ile Gln
             270                 275                 280

 gta gga ggc cat gtc ctt gca ggg ttt gaa agc atc acc cca ctg aca      974
 Val Gly Gly His Val Leu Ala Gly Phe Glu Ser Ile Thr Pro Leu Thr
         285                 290                 295

 gct gta gag aag ggt gct ttg ttt tta ctt gta tgc agt cgt ttt tgt     1022
 Ala Val Glu Lys Gly Ala Leu Phe Leu Leu Val Cys Ser Arg Phe Cys
     300                 305                 310

 cag tca ctt gtc atg gct gca tac tct tgc cag cta tac cca gag aac     1070
 Gln Ser Leu Val Met Ala Ala Tyr Ser Cys Gln Leu Tyr Pro Glu Asn
 315                 320                 325                 330

 aaa gac tat ctc atg gtt act gca aaa acc ggg tgg aaa cac tta cag     1118
 Lys Asp Tyr Leu Met Val Thr Ala Lys Thr Gly Trp Lys His Leu Gln
                 335                 340                 345

 caa atg ttt gac atg ggt cag aaa gct gta gaa gaa atc tgg ttt gaa     1166
 Gln Met Phe Asp Met Gly Gln Lys Ala Val Glu Glu Ile Trp Phe Glu
             350                 355                 360

 act gcc aaa tcc tat gaa tct ggg atc tcc atg tga                     1202
 Thr Ala Lys Ser Tyr Glu Ser Gly Ile Ser Met 
         365                 370





      <210> 259
      <211> 1851
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (39)..(1454)

      <400> 259
 tttcgtggga ccagcgcctg aggtgccccg gagaggcc    atg gag ctg agc agc      53
                                              Met Glu Leu Ser Ser
                                                1               5

 aag aag aag ctt cac gcc ctg tcc ctg gcc gag aag atc cag gtg ctg      101
 Lys Lys Lys Leu His Ala Leu Ser Leu Ala Glu Lys Ile Gln Val Leu
                  10                  15                  20

 gaa ctc ctg gat gag tcc aag atg tcc cag tcg gag gtg gcc cgg cgc      149
 Glu Leu Leu Asp Glu Ser Lys Met Ser Gln Ser Glu Val Ala Arg Arg
              25                  30                  35

 ttc cag gtt tcc cag ccc cag atc tcg cgc atc tgc aag aat aag gag      197
 Phe Gln Val Ser Gln Pro Gln Ile Ser Arg Ile Cys Lys Asn Lys Glu
          40                  45                  50

 aag ctg ctg gcg gac tgg tgc agc ggc aca gcc aac cga gag cgc aag      245
 Lys Leu Leu Ala Asp Trp Cys Ser Gly Thr Ala Asn Arg Glu Arg Lys
      55                  60                  65

 cgc aag cgg gag tcc aag tac agc ggg atc gac gag gct ctg ctc tgc      293
 Arg Lys Arg Glu Ser Lys Tyr Ser Gly Ile Asp Glu Ala Leu Leu Cys
  70                  75                  80                  85

 tgg tac cac att gcc cgg gcc aag gcc tgg gac gtg acg ggg ccc atg      341
 Trp Tyr His Ile Ala Arg Ala Lys Ala Trp Asp Val Thr Gly Pro Met
                  90                  95                 100

 ctg ctc cac aaa gcc aag gag ctg gcc gat atc atg ggc cag gac ttc      389
 Leu Leu His Lys Ala Lys Glu Leu Ala Asp Ile Met Gly Gln Asp Phe
             105                 110                 115

 gtg ccc agc atc ggc tgg ctg gtc cgc tgg aaa cgc cga aac aac gtc      437
 Val Pro Ser Ile Gly Trp Leu Val Arg Trp Lys Arg Arg Asn Asn Val
         120                 125                 130

 ggc ttt ggg gcc cgc cat gtt ctt gcg cct tca ttc ccc cct gag cca      485
 Gly Phe Gly Ala Arg His Val Leu Ala Pro Ser Phe Pro Pro Glu Pro
     135                 140                 145

 cct ccc ccg ggg ctc aca tcc cag gct cag ctg cct ctt tcc cta aaa      533
 Pro Pro Pro Gly Leu Thr Ser Gln Ala Gln Leu Pro Leu Ser Leu Lys
 150                 155                 160                 165

 gac ttc tct cca gag gac gtg ttt ggc tgt gct gaa ttg ccc ttg ctg      581
 Asp Phe Ser Pro Glu Asp Val Phe Gly Cys Ala Glu Leu Pro Leu Leu
                 170                 175                 180

 tat cgg gca gtg ccc ggc agc ttt ggt gca tgt gat caa gta cag gtg      629
 Tyr Arg Ala Val Pro Gly Ser Phe Gly Ala Cys Asp Gln Val Gln Val
             185                 190                 195

 ctg ctg tgt gcc aac agc agg ggc acc gag aag cgg cgg gta ctg ctg      677
 Leu Leu Cys Ala Asn Ser Arg Gly Thr Glu Lys Arg Arg Val Leu Leu
         200                 205                 210

 ggt ggg ctc cag gct gcc ccg aga tgc ttc ttt ggg atc cgc agt gag      725
 Gly Gly Leu Gln Ala Ala Pro Arg Cys Phe Phe Gly Ile Arg Ser Glu
     215                 220                 225

 gct ctg cct gcc tcc tac cac ccg gac ctg ggc atc ccc tgg tta gag      773
 Ala Leu Pro Ala Ser Tyr His Pro Asp Leu Gly Ile Pro Trp Leu Glu
 230                 235                 240                 245

 tgg ttg gca cag ttt gac cgg gac atg gga cag cag ggc cga cag gtg      821
 Trp Leu Ala Gln Phe Asp Arg Asp Met Gly Gln Gln Gly Arg Gln Val
                 250                 255                 260

 gct ttg ctg ctg gct gcc cga gtg gtg gag gag ctg gca ggc ctg cct      869
 Ala Leu Leu Leu Ala Ala Arg Val Val Glu Glu Leu Ala Gly Leu Pro
             265                 270                 275

 ggg ctc tac cac gtg aag ctc ttg cct ctg gcc gcc tct agc acc acg      917
 Gly Leu Tyr His Val Lys Leu Leu Pro Leu Ala Ala Ser Ser Thr Thr
         280                 285                 290

 cct ccc ctg ccc agc tca gtg gtc cgg gcc ttt aag gcc cat tac cga      965
 Pro Pro Leu Pro Ser Ser Val Val Arg Ala Phe Lys Ala His Tyr Arg
     295                 300                 305

 cac cgg ctg ttg ggc aaa ctg gct gcc atc caa agc gag agg gat ggc     1013
 His Arg Leu Leu Gly Lys Leu Ala Ala Ile Gln Ser Glu Arg Asp Gly
 310                 315                 320                 325

 acc tcg ctg gcc gag gcc ggg gca ggc atc acc gtg ctg gac gcc ctg     1061
 Thr Ser Leu Ala Glu Ala Gly Ala Gly Ile Thr Val Leu Asp Ala Leu
                 330                 335                 340

 cac gtg gcg tct gcc gcc tgg gcc aag gtg cct cct cag ctc att ttc     1109
 His Val Ala Ser Ala Ala Trp Ala Lys Val Pro Pro Gln Leu Ile Phe
             345                 350                 355

 agc agc ttc att caa gaa ggg ctg gct ccc ggc aaa acg ccc ccg tcc     1157
 Ser Ser Phe Ile Gln Glu Gly Leu Ala Pro Gly Lys Thr Pro Pro Ser
         360                 365                 370

 tcg cac aaa acc tct gag atg cca cca gtc ccc ggc ggg ctg agc ctg     1205
 Ser His Lys Thr Ser Glu Met Pro Pro Val Pro Gly Gly Leu Ser Leu
     375                 380                 385

 gag gag ttt tcc cgc ttt gtg gac ctg gag ggt gag gag cca agg tct     1253
 Glu Glu Phe Ser Arg Phe Val Asp Leu Glu Gly Glu Glu Pro Arg Ser
 390                 395                 400                 405

 gga gta tgt aag gag gag ata ggc act gaa gac gag aag ggg gac aga     1301
 Gly Val Cys Lys Glu Glu Ile Gly Thr Glu Asp Glu Lys Gly Asp Arg
                 410                 415                 420

 gag ggt gcc ttt gag ccc ctg ccc acc aaa gct gat gcc ctc cgg gcc     1349
 Glu Gly Ala Phe Glu Pro Leu Pro Thr Lys Ala Asp Ala Leu Arg Ala
             425                 430                 435

 ctg ggc acc ttg agg agg tgg ttt gaa tgc aac agc act tct cct gag     1397
 Leu Gly Thr Leu Arg Arg Trp Phe Glu Cys Asn Ser Thr Ser Pro Glu
         440                 445                 450

 cta ttc gaa aaa ttc tac gac tgt gag gag gag gtg gag cgg ctt tgc     1445
 Leu Phe Glu Lys Phe Tyr Asp Cys Glu Glu Glu Val Glu Arg Leu Cys
     455                 460                 465

 tgc cta tga aggcgcc ttcactgctt gccagagccc cttcctctct tgtttcccat     1501
 Cys Leu 
 470

 ggaaacggcc tcttcagaag gcagatcggg ctgtctcttt cctgtggaaa tagaactgtc   1561

 gtaaaggtgt agaagggaga gaagttggga caccaagtct gagcttggag tggcagtcgt   1621

 ccaaacccca ggaagagagc tctaaagatg gggcttcggg ggtaggaatc caggatgctt   1681

 agtttctaga ccctgcttga aagttctaga gcctttgaaa gggagttagt ctagaggcag   1741

 ccacttagaa aggtggaatt tgggcttttt ggacagactg cttccttgaa ctttgtgtta   1801

 aaaacagttc tgcttctgaa aataaagttt ttaatcagaa aaaaaaaaaa              1851




      <210> 260
      <211> 814
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (480)..(593)

      <400> 260
 cgctcggaaa aagaaacgtt agcgccgcgg gcgatcgacc aaatatcttg aacgctgccc     60

 ttcgcgagac aggatccgat acacaaagct gggttctcag gcaaggccga ctcagggttc    120

 tgcctagaaa cgcagagggc cctggcctgg attttaccag ggggcccgcc tctagtgaca    180

 cagtcaccta cggagggcct tctgctcatt cccacgaatt cccaccgtcc agattgggcc    240

 acttctttct cagctctaat gactttcctc agttccgtgg gttactcctg ccaactcgac    300

 gccggccgcc atgacactcg ctcggaaagc ggcagcggat catagaaaag cgccgcggtg    360

 gcgtagacag gccccgcgaa gccgccggac gtgtccttgg cgcaagggag gctgggatcg    420

 cggaggaccg agcgcgggct ggattaaccg cagccagtgc ctagcgcaag gttaggtgc     479                                                                 
 atg cag gcg gcc agc ttc ggc cgg gga agg aat ggc ctg gat aac tgg      527
 Met Gln Ala Ala Ser Phe Gly Arg Gly Arg Asn Gly Leu Asp Asn Trp
   1               5                  10                  15

 ggc atc gcg gcg ctc ctc ggc ctc ctg cag ctg cgt ttc aaa gca gag      575
 Gly Ile Ala Ala Leu Leu Gly Leu Leu Gln Leu Arg Phe Lys Ala Glu
              20                  25                  30

 ccg acc ctt ggt ggg tag tccggg gaccctgcgg accctccttg tgttgttgaa      629
 Pro Thr Leu Gly Gly 
          35

 acctagtgtt ttaattggga ctacacccag cagtgccggg agacttggcg gggacgttcc    689

 actgcgcagg aagtggcttc aaataactta cacgcgtcac tgtgtcgatt agctgctccg    749

 tgacaggcac tatggtagga gctgaggcta caaagataga acggatgggt tgcaaaaaaa    809

 aaaaa                                                                814




      <210> 261
      <211> 691
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (389)..(574)

      <400> 261
 aattagtcct gtatcttcat atgaaaagac attataaaca gcaaaactca ctttactaca     60

 gttttatttt tatcattccc tagcaatata ttactgatca ttgctagcat gtaaaatctt    120

 ttcatatttt tgcttaagag ccatatataa gtaatttatt aaataaaact tttctgattt    180

 gattcttcca ctttgtttca aatagtacct actgacagag gtttcccata cttttaacac    240

 acattgttag aagtatttta ttatatacac ttttaatggc tctattaacc ttaaaaaaaa    300

 agttaatgat atccacctaa atcactatcc ctgctaggaa gagaatcttg gtggtataaa    360

 aatgtaggcc tcttaatctg cattgtgg   atg gct ttg gcc aac cag ttg gca     412
                                  Met Ala Leu Ala Asn Gln Leu Ala
                                    1               5

 ttc ttg gac gcc ctg cca cag cat atg gat tcc gcc ctg atg aac ctt      460
 Phe Leu Asp Ala Leu Pro Gln His Met Asp Ser Ala Leu Met Asn Leu
      10                  15                  20

 act act atg gct atg gat ctt gat aaa gta tct gtt tcc atg tgt aat      508
 Thr Thr Met Ala Met Asp Leu Asp Lys Val Ser Val Ser Met Cys Asn
  25                  30                  35                  40

 ctc agc tta gaa gaa atc tgt gtg ggt tgg gtt aat ttt gga tct ttg      556
 Leu Ser Leu Glu Glu Ile Cys Val Gly Trp Val Asn Phe Gly Ser Leu
                  45                  50                  55

 cct aat aat gca tgt tga tgttat tgtgggtctg tgtttggttt tatttttata      610
 Pro Asn Asn Ala Cys 
              60

 tgttggtagc tgcagattaa ccccagcccc tctgtcttct gttaagtaca gttgatactg    670

 acattgttca ctcatcaaac c                                              691




      <210> 262
      <211> 1224
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(1008)

      <220>
      <221> misc_feature
      <222> (1)...(1224)
      <223> n = a,t,c or g

      <400> 262
 gaatacccgg ggcggggggc gcggccncgg ggcatgcgcg ctgcattgtt ttgactgaaa     60
                                                                 
 atg ccg tcg gtt tcg aaa gcg gcg gca gcg gcg ctg agc ggg tcc ccc      108
 Met Pro Ser Val Ser Lys Ala Ala Ala Ala Ala Leu Ser Gly Ser Pro
   1               5                  10                  15

 ccg cag acg gag aag ccg acc cac tac agg tac ctg aag gag ttc agg      156
 Pro Gln Thr Glu Lys Pro Thr His Tyr Arg Tyr Leu Lys Glu Phe Arg
              20                  25                  30

 acg gag cag tgc ccc ctg ttt tca cag cac aag tgc gcg cag cac cgg      204
 Thr Glu Gln Cys Pro Leu Phe Ser Gln His Lys Cys Ala Gln His Arg
          35                  40                  45

 ccg ttc acc tgc ttc cac tgg cac ttc ctc aac cag cgg cgc cgc agg      252
 Pro Phe Thr Cys Phe His Trp His Phe Leu Asn Gln Arg Arg Arg Arg
      50                  55                  60

 ccc ctc cgc agg cgc gac ggc acc ttc aac tac agc ccc gac gtg tac      300
 Pro Leu Arg Arg Arg Asp Gly Thr Phe Asn Tyr Ser Pro Asp Val Tyr
  65                  70                  75                  80

 tgc tcc aag tac aac gaa gcc acc ggc gtg tgc ccc gac ggc gac gag      348
 Cys Ser Lys Tyr Asn Glu Ala Thr Gly Val Cys Pro Asp Gly Asp Glu
                  85                  90                  95

 tgt ccc tac ctg cac cgg acg acg ggg gac aca gaa cgc aag tac cac      396
 Cys Pro Tyr Leu His Arg Thr Thr Gly Asp Thr Glu Arg Lys Tyr His
             100                 105                 110

 ctg cgt tac tac aaa aca gga acc tgc atc cac gag aca gac gca cgt      444
 Leu Arg Tyr Tyr Lys Thr Gly Thr Cys Ile His Glu Thr Asp Ala Arg
         115                 120                 125

 ggc cac tgc gtg aag aat ggg ctg cac tgt gcc ttc gcg cac ggc ccc      492
 Gly His Cys Val Lys Asn Gly Leu His Cys Ala Phe Ala His Gly Pro
     130                 135                 140

 ctg gac ctg cgg ccg ccc gtg tgt gac gtc agg gag ctg cag gcc cag      540
 Leu Asp Leu Arg Pro Pro Val Cys Asp Val Arg Glu Leu Gln Ala Gln
 145                 150                 155                 160

 gaa gcc ttg cag aac ggc cag ctg ggc ggc ggg gaa ggg gtc ccg gat      588
 Glu Ala Leu Gln Asn Gly Gln Leu Gly Gly Gly Glu Gly Val Pro Asp
                 165                 170                 175

 ctg cag cct ggg gtc ttg gcc agc cag gcc atg att gag aag atc ctg      636
 Leu Gln Pro Gly Val Leu Ala Ser Gln Ala Met Ile Glu Lys Ile Leu
             180                 185                 190

 agc gag gac ccc cgg tgg caa gat gcc aac ttc gtg ctg ggc agc tac      684
 Ser Glu Asp Pro Arg Trp Gln Asp Ala Asn Phe Val Leu Gly Ser Tyr
         195                 200                 205

 aag acg gag cag tgc ccg aag ccg cca cgc ctg tgc cgc cag ggc tat      732
 Lys Thr Glu Gln Cys Pro Lys Pro Pro Arg Leu Cys Arg Gln Gly Tyr
     210                 215                 220

 gcg tgc cca cac tac cac aat agc cgg gac agg cgg cgc aac ccc cgg      780
 Ala Cys Pro His Tyr His Asn Ser Arg Asp Arg Arg Arg Asn Pro Arg
 225                 230                 235                 240

 cgg ttc cag tac agg tcc acg ccc tgc ccc agt gtg aag cac ggg gat      828
 Arg Phe Gln Tyr Arg Ser Thr Pro Cys Pro Ser Val Lys His Gly Asp
                 245                 250                 255

 gag tgg ggg gaa ccc tca cgc tgc gat ggc ggc gac ggc tgc cag tat      876
 Glu Trp Gly Glu Pro Ser Arg Cys Asp Gly Gly Asp Gly Cys Gln Tyr
             260                 265                 270

 tgc cac tcc cgc acg gag cag cag ttc cat ccc gag gta cgt ccc tcc      924
 Cys His Ser Arg Thr Glu Gln Gln Phe His Pro Glu Val Arg Pro Ser
         275                 280                 285

 aac ccc cca ggc gta ggg gtc gct gga agg tcc cag aga agc tgt ggg      972
 Asn Pro Pro Gly Val Gly Val Ala Gly Arg Ser Gln Arg Ser Cys Gly
     290                 295                 300

 gtt cac agc gtg gtt atc aca cag aag gaa cag tga ttaa ctttggccga     1022
 Val His Ser Val Val Ile Thr Gln Lys Glu Gln 
 305                 310                 315

 gggctggcac aggtcgggaa gcctgggggt ggaggcatga gggcttgtac tggttgattt   1082

 gcttgctagg tggccttctg gctgtcctca gccagcgagt cttttctctt gtccttgtac   1142

 ttataatgag ttatgtgtta ctatgcttat agtatatgtc attaatacct ccatattcag   1202

 gccttgaatt aatgcgtgaa ct                                            1224




      <210> 263
      <211> 541
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(316)

      <400> 263
 cgggcaattc cttccctggg ccagccgagg gtctcagcct gggcccaagg acctctat       58                                                                 
 atg aag aga gct tac tca ccc cca gga att tcc tac ttc act cct tgt      106
 Met Lys Arg Ala Tyr Ser Pro Pro Gly Ile Ser Tyr Phe Thr Pro Cys
   1               5                  10                  15

 tcc ctc tcc tgc aca cac aca cac aca cac aca ccc cag gag act cta      154
 Ser Leu Ser Cys Thr His Thr His Thr His Thr Pro Gln Glu Thr Leu
              20                  25                  30

 ccc caa ctc agc cct aac cca gcc gaa caa cct tca gtg gct ccc cag      202
 Pro Gln Leu Ser Pro Asn Pro Ala Glu Gln Pro Ser Val Ala Pro Gln
          35                  40                  45

 tgc ctg aag aat atg atc caa act ttc cct gcc tac ctc tgt ctt ccc      250
 Cys Leu Lys Asn Met Ile Gln Thr Phe Pro Ala Tyr Leu Cys Leu Pro
      50                  55                  60

 ctt ttt tac gtg ctg gac ctg gcc ctt gct tct gct cct gta ctt tct      298
 Leu Phe Tyr Val Leu Asp Leu Ala Leu Ala Ser Ala Pro Val Leu Ser
  65                  70                  75                  80

 cat tca gct ctc ctc tga catgtt ttcttccttc cccacaaggc cagcaaaaat      352
 His Ser Ala Leu Leu 
                  85

 atcacctcct ccaggaagtc ctccatgacc acatgagctc accaggaact tccgcttttg    412

 agcccccaga aagagccatg ctgcagaagt ctccccatgc tgcttgtacc ccaaataaag    472

 tataggaggg gaataaaagg aaaaagccta gagccaggca cagcagtaca cgcccgcacg    532

 cgtggctcg                                                            541




      <210> 264
      <211> 1327
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(955)

      <400> 264
 aaggatcctt aattaaatta atccctcccc ccccccccga gctcagggcc ggtggcagta     60

 tgccgggaac   atg gcg ggg cag ccc gcg gcc acc ggc tcg ccg tct gcc     109
              Met Ala Gly Gln Pro Ala Ala Thr Gly Ser Pro Ser Ala
                1               5                  10

 gac aag gac gga atg gag ccc aac gtc gtg gct cgg atc tcg cag tgg      157
 Asp Lys Asp Gly Met Glu Pro Asn Val Val Ala Arg Ile Ser Gln Trp
      15                  20                  25

 gca gac gac cac ctg cgc cta gtc cgg aac atc agc act gga atg gcc      205
 Ala Asp Asp His Leu Arg Leu Val Arg Asn Ile Ser Thr Gly Met Ala
  30                  35                  40                  45

 ata gct gga ata atg tta ctt ttg aga agc att cga ctg aca tca aaa      253
 Ile Ala Gly Ile Met Leu Leu Leu Arg Ser Ile Arg Leu Thr Ser Lys
                  50                  55                  60

 ttt aca agc tct tcg gat att cca gta gaa ttt ata aga aga aat gtt      301
 Phe Thr Ser Ser Ser Asp Ile Pro Val Glu Phe Ile Arg Arg Asn Val
              65                  70                  75

 aaa cta cgt gga cga tta cgc cga ata act gag aat ggt tta gaa att      349
 Lys Leu Arg Gly Arg Leu Arg Arg Ile Thr Glu Asn Gly Leu Glu Ile
          80                  85                  90

 gaa cat ata cct att act tta cct att ata gct tca ttg aga aaa gag      397
 Glu His Ile Pro Ile Thr Leu Pro Ile Ile Ala Ser Leu Arg Lys Glu
      95                 100                 105

 cca cgt ggt gct ttg ctg gtt aag ttg gct gga gta gaa ctc gct gaa      445
 Pro Arg Gly Ala Leu Leu Val Lys Leu Ala Gly Val Glu Leu Ala Glu
 110                 115                 120                 125

 act ggg aag gca tgg tta caa aaa gag cta aaa cct tcc caa tta cta      493
 Thr Gly Lys Ala Trp Leu Gln Lys Glu Leu Lys Pro Ser Gln Leu Leu
                 130                 135                 140

 tgg ttc caa ctt ctt gga aag gag aat tca gca ctc ttt tgc tat ctt      541
 Trp Phe Gln Leu Leu Gly Lys Glu Asn Ser Ala Leu Phe Cys Tyr Leu
             145                 150                 155

 ctg gtg aat aag ggt gga tat ttc agc gtg aat ctg aat gaa gaa att      589
 Leu Val Asn Lys Gly Gly Tyr Phe Ser Val Asn Leu Asn Glu Glu Ile
         160                 165                 170

 ttg aga aga ggc ctt ggc aaa act gtt ctt gtt aaa ggg ctt aaa tat      637
 Leu Arg Arg Gly Leu Gly Lys Thr Val Leu Val Lys Gly Leu Lys Tyr
     175                 180                 185

 gat tct aaa atc tat tgg aca gtt cac aga aac tta ctt aaa gct gaa      685
 Asp Ser Lys Ile Tyr Trp Thr Val His Arg Asn Leu Leu Lys Ala Glu
 190                 195                 200                 205

 tta aca gcc tta aaa aaa gga gaa gga ata tgg aag gaa gac tct gaa      733
 Leu Thr Ala Leu Lys Lys Gly Glu Gly Ile Trp Lys Glu Asp Ser Glu
                 210                 215                 220

 aaa gaa agt tac tta gaa aaa ttc aaa gat tcc tgg aga gaa ata tgg      781
 Lys Glu Ser Tyr Leu Glu Lys Phe Lys Asp Ser Trp Arg Glu Ile Trp
             225                 230                 235

 aaa aag gac agt ttt tta aaa aca aca gga tca gat ttc agc ttg aaa      829
 Lys Lys Asp Ser Phe Leu Lys Thr Thr Gly Ser Asp Phe Ser Leu Lys
         240                 245                 250

 aaa gaa agt tat tat gaa aaa ctt aaa agg act tat gaa ata tgg aaa      877
 Lys Glu Ser Tyr Tyr Glu Lys Leu Lys Arg Thr Tyr Glu Ile Trp Lys
     255                 260                 265

 gac aac atg aac aac tgc tcc tta ata ctg aag ttc aga gaa ctt ata      925
 Asp Asn Met Asn Asn Cys Ser Leu Ile Leu Lys Phe Arg Glu Leu Ile
 270                 275                 280                 285

 agt cgc ata aac ttt cgt aga aaa ggg tga a acggtcaaga aatctagagg      976
 Ser Arg Ile Asn Phe Arg Arg Lys Gly 
                 290

 taaccttctc caaagagtga aatatgtaaa tatatggacg tttttcattg aatcaaaatg   1036

 gaagttttgc caaatgatca aagtgttagt ccaatggtat ttaaatatta aaaagagatg   1096

 attattataa gcataatgtc agaattaatt taaacaaatt ataattaatg taatatgatt   1156

 ttaggaagga tgaaacactt tatgagaagt taccaggctg aatgatttac atatatagtg   1216

 ctaatgtgtg aagagaaagt ttaactcttc acccactatg ttgtttttag ttattttggg   1276

 ctgccatatt gaattttttg tttgtttgtt ttgagaaggc gtttcgctct t            1327




      <210> 265
      <211> 483
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(483)

      <400> 265
  atg gtg cca gca tct gct tct ggt gag ggc ttc agg aag cta cca ctc      48
  Met Val Pro Ala Ser Ala Ser Gly Glu Gly Phe Arg Lys Leu Pro Leu
    1               5                  10                  15

 aag gca gaa gag gaa ggg gag cag gca tca tca cat ggc aag aga gga       96
 Lys Ala Glu Glu Glu Gly Glu Gln Ala Ser Ser His Gly Lys Arg Gly
              20                  25                  30

 gga aag aga gag ggt agg gag gtg aag aac tgt acg gtc tat atc cac      144
 Gly Lys Arg Glu Gly Arg Glu Val Lys Asn Cys Thr Val Tyr Ile His
          35                  40                  45

 gat gac tcc atg ttt gag cca gag gaa cag ttc agg gtc tac ctc ggc      192
 Asp Asp Ser Met Phe Glu Pro Glu Glu Gln Phe Arg Val Tyr Leu Gly
      50                  55                  60

 ctt cct ctt gga aac cac tgg agt gga gct aga att gga aag aat aac      240
 Leu Pro Leu Gly Asn His Trp Ser Gly Ala Arg Ile Gly Lys Asn Asn
  65                  70                  75                  80

 atg gcc acc atc acc ata tcc aat gat gaa gat gcc ccc acc att gag      288
 Met Ala Thr Ile Thr Ile Ser Asn Asp Glu Asp Ala Pro Thr Ile Glu
                  85                  90                  95

 ttt gaa gaa gct gca tac caa gtc cgg gaa ccc gca ggc cca gat gcc      336
 Phe Glu Glu Ala Ala Tyr Gln Val Arg Glu Pro Ala Gly Pro Asp Ala
             100                 105                 110

 att gcg att ctg aac atc aag gtg atc cgc aga ggg gat cag aac agg      384
 Ile Ala Ile Leu Asn Ile Lys Val Ile Arg Arg Gly Asp Gln Asn Arg
         115                 120                 125

 acc tcc aag gtt cgc tgc agc acg cgg gat ggc tct gcc cag tct ggt      432
 Thr Ser Lys Val Arg Cys Ser Thr Arg Asp Gly Ser Ala Gln Ser Gly
     130                 135                 140

 gtg gat tat tac cca aag agc cga gtc ttg aag ttc agt ccc ggt aat      480
 Val Asp Tyr Tyr Pro Lys Ser Arg Val Leu Lys Phe Ser Pro Gly Asn
 145                 150                 155                 160

 tga                                                                  483
 






      <210> 266
      <211> 1800
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1239)

      <400> 266
  atg acc gtg gtt tgt cac ctg gag ggc agt ggc cag tgg cca cag gac      48
  Met Thr Val Val Cys His Leu Glu Gly Ser Gly Gln Trp Pro Gln Asp
    1               5                  10                  15

 gct gag gcc gtg cag cgg gtc cga gct gcc ttc cag ctg cgc ctg gca       96
 Ala Glu Ala Val Gln Arg Val Arg Ala Ala Phe Gln Leu Arg Leu Ala
              20                  25                  30

 gag ctg ttg aca caa cag cat ggt ctg cag tgc cgt gcc act gcc acg      144
 Glu Leu Leu Thr Gln Gln His Gly Leu Gln Cys Arg Ala Thr Ala Thr
          35                  40                  45

 cac acg gat gtc ctt aag gat gga ttt gtg ttt cgg att cgc gtg gcc      192
 His Thr Asp Val Leu Lys Asp Gly Phe Val Phe Arg Ile Arg Val Ala
      50                  55                  60

 tat cag cgg gag ccc cag atc ctg aag gag gtg cag agc cca gag ggg      240
 Tyr Gln Arg Glu Pro Gln Ile Leu Lys Glu Val Gln Ser Pro Glu Gly
  65                  70                  75                  80

 atg atc tcg ctg agg gac aca gct gcc tcc ctc cgc ctt gag aga gac      288
 Met Ile Ser Leu Arg Asp Thr Ala Ala Ser Leu Arg Leu Glu Arg Asp
                  85                  90                  95

 aca agg cag ttg cca ctg ctc acc agt gcc ctg cac gga ctg cag cag      336
 Thr Arg Gln Leu Pro Leu Leu Thr Ser Ala Leu His Gly Leu Gln Gln
             100                 105                 110

 cag cac cca gcc ttc tct ggt gtg gca cgg ctg gcc aag cgg tgg gtg      384
 Gln His Pro Ala Phe Ser Gly Val Ala Arg Leu Ala Lys Arg Trp Val
         115                 120                 125

 cgt gcc cag ctt ctt ggt gag ggt ttc gct gat gag agc ctg gat ctg      432
 Arg Ala Gln Leu Leu Gly Glu Gly Phe Ala Asp Glu Ser Leu Asp Leu
     130                 135                 140

 gtg gcc gct gcc ctt ttc ctg cac cct gag ccc ttc acc cct ccg agt      480
 Val Ala Ala Ala Leu Phe Leu His Pro Glu Pro Phe Thr Pro Pro Ser
 145                 150                 155                 160

 tcc ccc cag gtt ggc ttc ctt cga ttc ctt ttc ttg gta tca acg ttt      528
 Ser Pro Gln Val Gly Phe Leu Arg Phe Leu Phe Leu Val Ser Thr Phe
                 165                 170                 175

 gat tgg aag aac aac ccc ctc ttt gtc aac ctc aat aat gag ctc act      576
 Asp Trp Lys Asn Asn Pro Leu Phe Val Asn Leu Asn Asn Glu Leu Thr
             180                 185                 190

 gtg gag gag cag gtg gag atc cgc agt ggc ttc ctg gca gct cgg gca      624
 Val Glu Glu Gln Val Glu Ile Arg Ser Gly Phe Leu Ala Ala Arg Ala
         195                 200                 205

 cag ctc ccc gtc atg gtc att gtt acc ccc caa gac cgc aaa aac tct      672
 Gln Leu Pro Val Met Val Ile Val Thr Pro Gln Asp Arg Lys Asn Ser
     210                 215                 220

 gtg tgg aca cag gat gga ccc tca gcc cag atc ctg cag cag ctt gtg      720
 Val Trp Thr Gln Asp Gly Pro Ser Ala Gln Ile Leu Gln Gln Leu Val
 225                 230                 235                 240

 gtc ctg gca gct gaa gcc ctg ccc atg tta gag aag cag ctc atg gat      768
 Val Leu Ala Ala Glu Ala Leu Pro Met Leu Glu Lys Gln Leu Met Asp
                 245                 250                 255

 ccc cgg gga cct ggg gac atc agg aca gtg ttc cgg ccg ccc ttg gac      816
 Pro Arg Gly Pro Gly Asp Ile Arg Thr Val Phe Arg Pro Pro Leu Asp
             260                 265                 270

 att tac gac gtg ctg att cgc ctg tct cct cgc cat atc ccg cgg cac      864
 Ile Tyr Asp Val Leu Ile Arg Leu Ser Pro Arg His Ile Pro Arg His
         275                 280                 285

 cgc cag gct gtg gac tcg cca gct gcc tcc ttc tgc cgg ggc ctg ctc      912
 Arg Gln Ala Val Asp Ser Pro Ala Ala Ser Phe Cys Arg Gly Leu Leu
     290                 295                 300

 agc cag ccg ggg ccc tca tcc ctg atg ccc gtg ctg ggc tat gat cct      960
 Ser Gln Pro Gly Pro Ser Ser Leu Met Pro Val Leu Gly Tyr Asp Pro
 305                 310                 315                 320

 cct cag ctc tat ctg acg cag ctc agg gag gcc ttt ggg gat ctg gcc     1008
 Pro Gln Leu Tyr Leu Thr Gln Leu Arg Glu Ala Phe Gly Asp Leu Ala
                 325                 330                 335

 ctt ttc ttc tat gac cag cat ggt gga gag gtg att ggt gtc ctc tgg     1056
 Leu Phe Phe Tyr Asp Gln His Gly Gly Glu Val Ile Gly Val Leu Trp
             340                 345                 350

 aag ccc acc agc ttc cag ccg cag ccc ttc aag gcc tcc agc aca aag     1104
 Lys Pro Thr Ser Phe Gln Pro Gln Pro Phe Lys Ala Ser Ser Thr Lys
         355                 360                 365

 ggg cgc atg gtg atg tct cga ggt ggg gag cta gta atg gtg ccc aat     1152
 Gly Arg Met Val Met Ser Arg Gly Gly Glu Leu Val Met Val Pro Asn
     370                 375                 380

 gtt gaa gca atc ctg gag gac ttt gct gtg ctg ggt gaa ggc ctg gtg     1200
 Val Glu Ala Ile Leu Glu Asp Phe Ala Val Leu Gly Glu Gly Leu Val
 385                 390                 395                 400

 cag act gtg gag gcc cga agt gag agg tgg act gtg tga tcccagctct      1249
 Gln Thr Val Glu Ala Arg Ser Glu Arg Trp Thr Val 
                 405                 410

 ggagcaagct gtagacggac agcaggacat tggacctcta gagcaagatg tcagtaggat   1309

 gacctccacc ctccttggac atgaatcctc catggagggc ctgctggctg aacatgctga   1369

 atcatctcca acaaaaccca gccccaactt tctctctgat gctccagcat tggggcaggg   1429

 gcatggtggc ccatgtagtc tcctgggcct caccatccca gaagaggagt gggagccagc   1489

 tcagagaagg aactgaaccc aggagatcca tccacctatt agccctgggc ctggacctcc   1549

 ctgcgatttc ccactccttt cttagtcttc ttccagaaac agagaagggg atgtgtgcct   1609

 gggagaggct ctgtctcctt cctgctgcca ggacctgtgc ctagacttag catgcccttc   1669

 actgcagtgt caggccttta gatgggaccc agcgaaaatg tggcccttct gagtcacatc   1729

 accgacactg agcagtggaa aggggctata tgtgtatgaa tagaccacat tgaaggagca   1789

 aaaaaaaaaa a                                                        1800




      <210> 267
      <211> 651
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (134)..(409)

      <400> 267
 ccgaaggaaa ccaggaggac tttctgccac tggaacatct agtcacagtc ctagtgagtg     60

 tcaggagcct tcctcgtcca ggccttccag gatagaccct caagagccca ctcactctaa    120

 accactagcc cca   atg gag ctg gag cca atg tac agc aat gta aat cct     169
                  Met Glu Leu Glu Pro Met Tyr Ser Asn Val Asn Pro
                    1               5                  10

 gga gat agc aac ccg att tat tcc cag atc tgg agc atc cag cat aca      217
 Gly Asp Ser Asn Pro Ile Tyr Ser Gln Ile Trp Ser Ile Gln His Thr
          15                  20                  25

 aaa gaa aac tca gct aat tgt cca atg atg cat caa gag cat gag gaa      265
 Lys Glu Asn Ser Ala Asn Cys Pro Met Met His Gln Glu His Glu Glu
      30                  35                  40

 ctt aca gtc ctc tat tca gaa ctg aag aag aca cac cca gac gac tct      313
 Leu Thr Val Leu Tyr Ser Glu Leu Lys Lys Thr His Pro Asp Asp Ser
  45                  50                  55                  60

 gca ggg gag gct agc agc aga ggc agg gcc cat gaa gaa gat gat gaa      361
 Ala Gly Glu Ala Ser Ser Arg Gly Arg Ala His Glu Glu Asp Asp Glu
                  65                  70                  75

 gaa aac tat gag aat gta cca cgt gta tta ctg gcc tca gac cac tag      409
 Glu Asn Tyr Glu Asn Val Pro Arg Val Leu Leu Ala Ser Asp His 
              80                  85                  90

 ccccttaccc agagtggccc acaggaaaca gcctgcacca tttttttttc tgttctctcc    469

 aaccacacat gatccatctc tccagactct gcctcctacg aagctgggct gcagggtatg    529

 tgaggctgag cataagggct gcaaatctcc cctgtgcctg atctgagtgt ccccaggaag    589

 agagcaggca gcctctgagc aagcactggg gtattttcac agtggagaca cgtggctagg    649

 ca                                                                   651




      <210> 268
      <211> 490
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (11)..(439)

      <400> 268
 agtaggcaag   atg gcg tcg agc ggc ggg gag cta ggg agt tta ttt gat      49
              Met Ala Ser Ser Gly Gly Glu Leu Gly Ser Leu Phe Asp
                1               5                  10

 cac cac gtc cag agg gcg gta tgc gac aca cgg gcc aaa tat cga gag       97
 His His Val Gln Arg Ala Val Cys Asp Thr Arg Ala Lys Tyr Arg Glu
      15                  20                  25

 gga cga cgg cct cgt gct gtg aag gta tat aca atc aat ttg gaa tct      145
 Gly Arg Arg Pro Arg Ala Val Lys Val Tyr Thr Ile Asn Leu Glu Ser
  30                  35                  40                  45

 cag tac tta tta ata caa gga gtt cct gct gtg gga gtc atg aag gaa      193
 Gln Tyr Leu Leu Ile Gln Gly Val Pro Ala Val Gly Val Met Lys Glu
                  50                  55                  60

 tta gtt gag cga ttc gct tta tat ggt gca att gaa cag tac aat gct      241
 Leu Val Glu Arg Phe Ala Leu Tyr Gly Ala Ile Glu Gln Tyr Asn Ala
              65                  70                  75

 cta gat gaa tac cca gca gaa gac ttt act gaa gtt tat ctt att aaa      289
 Leu Asp Glu Tyr Pro Ala Glu Asp Phe Thr Glu Val Tyr Leu Ile Lys
          80                  85                  90

 ttt atg aac tta caa agt gca agg aca gcc aag aga aaa atg gat gaa      337
 Phe Met Asn Leu Gln Ser Ala Arg Thr Ala Lys Arg Lys Met Asp Glu
      95                 100                 105

 cag agt ttc ttc ggt gga ttg ctt cat gtg tgc tat gct cca gaa ttt      385
 Gln Ser Phe Phe Gly Gly Leu Leu His Val Cys Tyr Ala Pro Glu Phe
 110                 115                 120                 125

 gaa aca gtt gaa gaa act aga aaa aaa cta caa atg cgg caa ggc ata      433
 Glu Thr Val Glu Glu Thr Arg Lys Lys Leu Gln Met Arg Gln Gly Ile
                 130                 135                 140

 tgc tag taaaaactac tgaaaataaa gaccattacg tgacaaagaa gaaattggtt       489
 Cys 


 a                                                                    490




      <210> 269
      <211> 859
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (180)..(695)

      <400> 269
 agggctctga ctgccagcga ctgctctggg ggtgtctgcg atcaaggacg atcctgggta     60

 tgggggaggg ccaggcacca tgaagccagt gtgggtcgcc acccttctgt ggatgctact    120

 gctggtgccc aggctggggg ccgcccggaa ggggtcccca gaagaggcct ccttctact     179                                                                 
 atg gaa cct tcc ctc ttg gag gac atc att ctg ctg agg gaa ctg cac      227
 Met Glu Pro Ser Leu Leu Glu Asp Ile Ile Leu Leu Arg Glu Leu His
   1               5                  10                  15

 gtc aac cac tac cga ttc tcc ctg tct tgg ccc cgg ctc ctg ccc aca      275
 Val Asn His Tyr Arg Phe Ser Leu Ser Trp Pro Arg Leu Leu Pro Thr
              20                  25                  30

 ggc atc cga gcc gag cag gtg aac aag aag gga atc gaa ttc tac agt      323
 Gly Ile Arg Ala Glu Gln Val Asn Lys Lys Gly Ile Glu Phe Tyr Ser
          35                  40                  45

 gat ctt atc gat gcc ctt ctg agc agc aac atc act ccc atc gtg acc      371
 Asp Leu Ile Asp Ala Leu Leu Ser Ser Asn Ile Thr Pro Ile Val Thr
      50                  55                  60

 ttg cac cac tgg gat ctg cca cag ctg ctc cag gtc aaa tac ggt ggg      419
 Leu His His Trp Asp Leu Pro Gln Leu Leu Gln Val Lys Tyr Gly Gly
  65                  70                  75                  80

 tgg cag aat gtg agc atg gcc aac tac ttc aga gac tac gcc aac ctg      467
 Trp Gln Asn Val Ser Met Ala Asn Tyr Phe Arg Asp Tyr Ala Asn Leu
                  85                  90                  95

 tgc ttt gag gcc ttt ggg gac cgt gtg aag cac tgg atc acg ttc agt      515
 Cys Phe Glu Ala Phe Gly Asp Arg Val Lys His Trp Ile Thr Phe Ser
             100                 105                 110

 gat cct cgg gca atg gca gaa aaa ggc tat gag acg ggc cac cat gcg      563
 Asp Pro Arg Ala Met Ala Glu Lys Gly Tyr Glu Thr Gly His His Ala
         115                 120                 125

 ccg ggc ctg aag ctc cgc ggc acc ggc ctg tac aaa gca gca cac cac      611
 Pro Gly Leu Lys Leu Arg Gly Thr Gly Leu Tyr Lys Ala Ala His His
     130                 135                 140

 atc att aag gcc cac gcc aaa gcc tgg cat tct tat aac acc acg tgg      659
 Ile Ile Lys Ala His Ala Lys Ala Trp His Ser Tyr Asn Thr Thr Trp
 145                 150                 155                 160

 cgc aac aag caa caa ggg ctg ggg gaa ttt cat tga actg tgactggggg      709
 Arg Asn Lys Gln Gln Gly Leu Gly Glu Phe His 
                 165                 170

 aaaccgcgga cattagtaac cccaggacct aaaggtgcga aagaaactca agtctgcttg    769

 gctggtggcc acccattgat gctggggcta ccccaggatg aggaatactt ggaaaaaaag    829

 ccaacccatc cggatagtgc ggtatcaggc                                     859




      <210> 270
      <211> 398
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (160)..(318)

      <400> 270
 actacgccaa cctgtgcttt gaggcctttg gggaccgtgt gaagcactgg atcacgttca     60

 gtgatcctcg ggtaagcagg gcccctccag gtgggagaat gtgacactcc ctgccacttc    120

 ttatggatcc tgtggtcctg cttgctgtcc ctataggca   atg gca gaa aaa ggc     174
                                              Met Ala Glu Lys Gly
                                                1               5

 tat gag acg ggc cac cat gcg ccg ggc ctg aag ctc cgc ggc acc ggc      222
 Tyr Glu Thr Gly His His Ala Pro Gly Leu Lys Leu Arg Gly Thr Gly
                  10                  15                  20

 ctg tac aag gca gca cac cac atc att aag gtg agg tgg gtc ctt ctg      270
 Leu Tyr Lys Ala Ala His His Ile Ile Lys Val Arg Trp Val Leu Leu
              25                  30                  35

 gtg gag gaa cag cct cag ggt cag ctc agc ctg ccc cag ggg ctc tag      318
 Val Glu Glu Gln Pro Gln Gly Gln Leu Ser Leu Pro Gln Gly Leu 
          40                  45                  50

 cctgagcttg gtccaaaacc gctccacctc cgagtcagca tactccatag cacacgaaat    378

 cgtcgacccg cgaattccgg                                                398




      <210> 271
      <211> 395
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (146)..(301)

      <400> 271
 acgtcattcg tgtatgacaa ccacaagagt tgcttgttaa gaagcaagta tgctagtcat     60

 ttgatgactt aatcttttat cttggccgcc cggggccttc agttcagggt gttgatttca    120

 tcagaactaa cctagaaaga atgat  atg aaa ctt cgt gag tgc ccg gcc ctc     172
                              Met Lys Leu Arg Glu Cys Pro Ala Leu
                                1               5

 cga tgg tcc cag ctg tcc cag cac aag ctg gag tgt cta ttg ctt tac      220
 Arg Trp Ser Gln Leu Ser Gln His Lys Leu Glu Cys Leu Leu Leu Tyr
  10                  15                  20                  25

 ctg gca gag agc tcc ggg ctc aga aca gga aat gtg gga gtt ctc cac      268
 Leu Ala Glu Ser Ser Gly Leu Arg Thr Gly Asn Val Gly Val Leu His
                  30                  35                  40

 cca act ttg aca gac ggg agt gga aag gag tga agcgagcg gaagtctgac      319
 Pro Thr Leu Thr Asp Gly Ser Gly Lys Glu 
              45                  50

 ttcatttttg gttttcagac tgtcagactg gaagggtaac tttaagtggg ggctcgcttc    379

 cccccccccc cttagt                                                    395




      <210> 272
      <211> 1361
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (198)..(1262)

      <400> 272
 cgacccgaaa ttcggcacga ggctgttttg ggcggacgct gtgacgagag gaggaattac     60

 tctagggtac aaggcctcgc ccaggagtgg ggggttgctt ccgggtcgcg ctcccggaaa    120

 caggaagttg cccatcctcc tcgcccggcg gcagctgtcc ccgaggcggg aggagcccga    180

 gggggcgcga gccccgc   atg gat ttt ata ttg gaa gac atg gat ctt gct     230
                      Met Asp Phe Ile Leu Glu Asp Met Asp Leu Ala
                        1               5                  10

 gcc aac gag atc agc att tat gac aaa ctt tca gag act gtt gat ttg      278
 Ala Asn Glu Ile Ser Ile Tyr Asp Lys Leu Ser Glu Thr Val Asp Leu
              15                  20                  25

 gtg aga cag acc ggc cat cag tgt ggc atg tca gag aag gca att gaa      326
 Val Arg Gln Thr Gly His Gln Cys Gly Met Ser Glu Lys Ala Ile Glu
          30                  35                  40

 aaa ttt atc aga cag ctg ctg gaa aag aat gaa cct cag aga ccc ccc      374
 Lys Phe Ile Arg Gln Leu Leu Glu Lys Asn Glu Pro Gln Arg Pro Pro
      45                  50                  55

 ccg cag tat cct ctc ctt ata gtt gtg tat aag gtt ctc gca acc ttg      422
 Pro Gln Tyr Pro Leu Leu Ile Val Val Tyr Lys Val Leu Ala Thr Leu
  60                  65                  70                  75

 gga tta atc ttg ctc act gcc tac ttt gtg att caa cct ttc agc cca      470
 Gly Leu Ile Leu Leu Thr Ala Tyr Phe Val Ile Gln Pro Phe Ser Pro
                  80                  85                  90

 tta gca cct gag cca gtg ctt tct gga gct cac acc tgg cgc tca ctc      518
 Leu Ala Pro Glu Pro Val Leu Ser Gly Ala His Thr Trp Arg Ser Leu
              95                 100                 105

 atc cat cac att agg ctg atg tcc ttg ccc att gcc aag aag tac atg      566
 Ile His His Ile Arg Leu Met Ser Leu Pro Ile Ala Lys Lys Tyr Met
         110                 115                 120

 tca gaa aat aag gga gtt cct ctg cat ggg ggt gat gaa gac aga ccc      614
 Ser Glu Asn Lys Gly Val Pro Leu His Gly Gly Asp Glu Asp Arg Pro
     125                 130                 135

 ttt cca gac ttt gac ccc tgg tgg aca aac gac tgt gag cag aat gag      662
 Phe Pro Asp Phe Asp Pro Trp Trp Thr Asn Asp Cys Glu Gln Asn Glu
 140                 145                 150                 155

 tca gag ccc att cct gcc aac tgc act ggc tgt gcc cag aaa cac ctg      710
 Ser Glu Pro Ile Pro Ala Asn Cys Thr Gly Cys Ala Gln Lys His Leu
                 160                 165                 170

 aag gtg atg ctc ctg gaa gac gcc cca agg aaa ttt gag agg ctc cat      758
 Lys Val Met Leu Leu Glu Asp Ala Pro Arg Lys Phe Glu Arg Leu His
             175                 180                 185

 cca ctg gtg atc aag acg gga aag ccc ctg ttg gag gaa gag att cag      806
 Pro Leu Val Ile Lys Thr Gly Lys Pro Leu Leu Glu Glu Glu Ile Gln
         190                 195                 200

 cat ttt ttg tgc cag tac cct gag gcg aca gaa ggc ttc tct gaa ggg      854
 His Phe Leu Cys Gln Tyr Pro Glu Ala Thr Glu Gly Phe Ser Glu Gly
     205                 210                 215

 ttt ttc gcc aag tgg tgg cgc tgc ttt cct gag cgg tgg ttc cca ttt      902
 Phe Phe Ala Lys Trp Trp Arg Cys Phe Pro Glu Arg Trp Phe Pro Phe
 220                 225                 230                 235

 cct tat cca tgg agg aga cct ctg aac aga tca caa atg tta cgt gag      950
 Pro Tyr Pro Trp Arg Arg Pro Leu Asn Arg Ser Gln Met Leu Arg Glu
                 240                 245                 250

 ctt ttt cct gtt ttc act cac ctg cca ttt cca aaa gat gcc tct tta      998
 Leu Phe Pro Val Phe Thr His Leu Pro Phe Pro Lys Asp Ala Ser Leu
             255                 260                 265

 aac aag tgc tcc ttt ctt cac cca gaa cct gtt gtg ggg agt aag atg     1046
 Asn Lys Cys Ser Phe Leu His Pro Glu Pro Val Val Gly Ser Lys Met
         270                 275                 280

 cat aag atg cct gac cta ttt atc att ggc agc ggt gag gcc atg ttg     1094
 His Lys Met Pro Asp Leu Phe Ile Ile Gly Ser Gly Glu Ala Met Leu
     285                 290                 295

 cag ctc atc cct ccc ttc cag tgc cga aga cat tgt cag tct gtg gcc     1142
 Gln Leu Ile Pro Pro Phe Gln Cys Arg Arg His Cys Gln Ser Val Ala
 300                 305                 310                 315

 atg cca ata gag cca ggg gat atc ggc tat gtc gac acc acc cac tgg     1190
 Met Pro Ile Glu Pro Gly Asp Ile Gly Tyr Val Asp Thr Thr His Trp
                 320                 325                 330

 aag gtc tac gtt ata gcc aga ggg gtc cag cct ttg gtc atc tgc gat     1238
 Lys Val Tyr Val Ile Ala Arg Gly Val Gln Pro Leu Val Ile Cys Asp
             335                 340                 345

 gga acc gct ttc tca gaa ctg tag gaaatagaac tgtgcacagg aacagcttcc    1292
 Gly Thr Ala Phe Ser Glu Leu 
         350

 agagccgaaa accaggttga aaggggaaaa ataaaaacaa aaacgatgaa actgcaaaaa   1352

 aaaaaaaaa                                                           1361




      <210> 273
      <211> 2532
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1170)..(1682)

      <400> 273
 aagcaacgaa acataaaaca cacaagcgcc ccgtgccccc agtgactctg ggcctcacag     60

 agcccccgcc agccagcatg gggccccgcc ctgcagccag tcacgcgccc ccacaccgca    120

 gccccccgtg gctgtccttc caaccccacg tgctttttct ttctcctgcc cgcttctttt    180

 cttcatcaca aaaggcgtgg agactcggag acggacgttt ttcccctttt ttaagttatt    240

 gacgcccagc gcgcctcgcc tcttcaccca tcaacgctgt gctttgccca ctggactcct    300

 gaagaggggg tggggggctc cctcggtcgc ccaccctggg aagtgcctaa ccttttattt    360

 tattttattt ttttgaggaa aaagaacgcc tgactcacag gttgaagaaa caccctgggc    420

 cctctctcat ggccgggttc cccgtccctc tgcagaggct gggaagggtc cccgggctgg    480

 agccacgggg gcttctctgg gctgtgcctc cggggccaac actggctgct tggggctgcc    540

 cggggactcc agagggctgc acggccaccc tgccctggct agagcgcacc ccaccggagc    600

 ccacgtgggc tgggcggctg gagggatggt cccccggtga cactgggaga aaggccactt    660

 ggatgggggc gtttctgttt tgttccgctt tgtgatgtca ccaatttgga aacagcgagg    720

 gtgggtgggg acttttacag aatattctca ggtgtgtacc cgagaggcag agagagggac    780

 gtggccggca gctctgtgcg tggccttgtc ccaagcactt gcgcccgccc ccgagcgccg    840

 cccccgggga gcgggaagcc agcactcgca ctttggccag gggcgcgtgg aaggtggtgg    900

 caggcaccgg cctgggcagc ttccaggcct ggctggccac gaccacggcc cgagggggag    960

 cccgccaggc cacgccgcac tgagccacag ccccgggggc cgcctcccgg gggccccttg   1020

 aggcactgag gcaccgagac tggttctccc cgagagactc ggaaggtggg gaacgagggg   1080

 actgtgtttg gggaggtggc tttttcgtct gctgttgact gaacactaca gcgccctgtg   1140

 gttccgggct tcgcacagct gtcccaggg  atg gat cgc ctg tgc tgc ctt cgc    1193
                                  Met Asp Arg Leu Cys Cys Leu Arg
                                    1               5

 ccg ccg cca cac cgg gac cct gca cgg ctg ctt ctg gcc tcg aca gat     1241
 Pro Pro Pro His Arg Asp Pro Ala Arg Leu Leu Leu Ala Ser Thr Asp
      10                  15                  20

 gac aaa aga aac agc ccc aaa ata cga cca ctc caa cca gca gtt ccc     1289
 Asp Lys Arg Asn Ser Pro Lys Ile Arg Pro Leu Gln Pro Ala Val Pro
  25                  30                  35                  40

 gcc tgc ctg ccc gcc act gtc agg cct gcc ctg gcc tcc tcg tcc gca     1337
 Ala Cys Leu Pro Ala Thr Val Arg Pro Ala Leu Ala Ser Ser Ser Ala
                  45                  50                  55

 ggg ctg tct gct ggc ttc tgg ggg cag aag agc ggg gag ccc cgt gga     1385
 Gly Leu Ser Ala Gly Phe Trp Gly Gln Lys Ser Gly Glu Pro Arg Gly
              60                  65                  70

 agg gtc agg gga gac cag gtc agg gca gct aca ttt ctg gtg atc agc     1433
 Arg Val Arg Gly Asp Gln Val Arg Ala Ala Thr Phe Leu Val Ile Ser
          75                  80                  85

 ccc atg ggg aga cgg ggc tgg cgg gat acc gcc ccc ccg gct tcc cca     1481
 Pro Met Gly Arg Arg Gly Trp Arg Asp Thr Ala Pro Pro Ala Ser Pro
      90                  95                 100

 cac cac ttc tgt ctc acc cgg aag cgt cct ttt ttt gtg cca ggt gtc     1529
 His His Phe Cys Leu Thr Arg Lys Arg Pro Phe Phe Val Pro Gly Val
 105                 110                 115                 120

 tac cta aga ggg ttg gtg cca gaa gcc ccc cat ggc gag tgc tgg ggc     1577
 Tyr Leu Arg Gly Leu Val Pro Glu Ala Pro His Gly Glu Cys Trp Gly
                 125                 130                 135

 ccg gcg gtg ccc tgg ggg agc aga tgg ggc cac ccc tgg cag ggc cgc     1625
 Pro Ala Val Pro Trp Gly Ser Arg Trp Gly His Pro Trp Gln Gly Arg
             140                 145                 150

 tac aac ttt ttc cag cag cgg agc cct ctg ggg ggc ctg tgc ttg tgg     1673
 Tyr Asn Phe Phe Gln Gln Arg Ser Pro Leu Gly Gly Leu Cys Leu Trp
         155                 160                 165

 cat ctc tga gggccca gattgcacaa ggtgacctgg ccgtggcctg agggtggagt     1729
 His Leu 
     170

 cgcccagcac gcaggccggg gcgctgcggg gctaagtatt aggccttccc agggaggggg   1789

 cgtgccaagc atcccagagc cgggctggga ccgccaaaac gtcgtggcct ggatcctctg   1849

 ggtctgagtg cctgatcccc tgccccccaa aaaagcagag gtaggtgttg caggcccagg   1909

 gcaggggtgc ctgccccagg agagtcccag gcagtggttc tcgtgccagt ggcacccagg   1969

 ggcaaggaca gccaaccccc acccttgcca cgtgtggggc cacgtgggca tgtggggtgt   2029

 gtgtttttac cttggtgaat ctcacctgcc aacgatttct cgtgagtgcc gaccaccttc   2089

 tccgaccatg ttacgcccgg gcggcagcag cccccggcca ctgcaaaccc atgccctggg   2149

 tccctcggct cccccaggga ggcatccccg tgccaatgtc ccccagtggt ggcagcagat   2209

 cctgtggccg gcctggcgga cgggacccag tgatacttgt atattacaca gtcctgattt   2269

 cagacaattt caaccttaat ctatttaaaa aagaatattc tatacaagct gtttttaagc   2329

 cttttaccat ttgaaatgca tgtgttgtgc gcgttgggga tgggaggagg ggctgaggag   2389

 cggctcagtg tcacctccca cagccaccgg ccctgaccct taatccagac accgatggaa   2449

 gtcgactttt catatctttc tcctgaaatg aactctgttt taaattggaa taaattttgt   2509

 tcctaaatgc aaaaaaaaaa aaa                                           2532




      <210> 274
      <211> 910
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (676)..(870)

      <400> 274
 cccattcata ttaactccat cttttaaaaa tgtcatgatt acaaagtgaa aagatttggc     60

 tttcttagag gctcaatcac agaggtgaaa gtgaccttgg aaatcatata ctctatcccc    120

 atgttacaca gattagaaaa actgaggtta tggcactgac ttaggcaccc ccagcaaggc    180

 aacccaggga ctacaactgg caatcccaac tcctgggcta gggctttttc tacctttttt    240

 tgcattggcc tcttaaagag gcaatgaata ctaattcctg gcatcagaaa aaaaaaaagg    300

 catgaggtgg gaggattctt ttttccctga tgggaaacag tgaataagaa aaatctcatc    360

 attcgatgga agaggtgact taataatttt attaatgaat ttgatgtccc atgttttgta    420

 gttttgttat cattgaacca ttggggctgg aatctgccta aataatttta tcttggtagc    480

 cagcaattat gttggtattt tatgtgggcc ttcccagatt ttcatattaa tgaaatgact    540

 aatagtcgta cttaagaggt aactctacta aagcagaatg agatctaata tgttgtggaa    600

 ataaaagagt ttgcagtgga atgatactct cactccgtgc ttgtaaaatt gagttctatt    660

 caagacggaa ctgct atg act ggc cta ttc aag gct tca tat ttt tat aca     711
                  Met Thr Gly Leu Phe Lys Ala Ser Tyr Phe Tyr Thr
                    1               5                  10

 gac tat ttc aca gac cat aga ttt att tta aaa ggg aaa atc tca cac      759
 Asp Tyr Phe Thr Asp His Arg Phe Ile Leu Lys Gly Lys Ile Ser His
          15                  20                  25

 ata att aag cag tgg aaa atg tgc tca atg cta tgg tgc gtc agg ccc      807
 Ile Ile Lys Gln Trp Lys Met Cys Ser Met Leu Trp Cys Val Arg Pro
      30                  35                  40

 tct gtc tac cag gtt tct ccc ctt tct gca gag ctg tgg acc ctg tac      855
 Ser Val Tyr Gln Val Ser Pro Leu Ser Ala Glu Leu Trp Thr Leu Tyr
  45                  50                  55                  60

 gta cca aac agg tga acttggtcca tctttccttc ttcctttttt tgcacatttg      910
 Val Pro Asn Arg 






      <210> 275
      <211> 744
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (355)..(537)

      <400> 275
 cggacgcgtg ggaatctatg ggcactcttg gctctgggct cggacggctg gcttctgcct     60

 acccgagcct taacctttca aggaccagaa ggattccaga gctcttgccc taggtcctgg    120

 ggcagcgatg actcactgca gcaccccctc ccacttcgcc aagctgccgt ctccgcccac    180

 ccccaaacaa tctcgacagc gcatttcggg agccacggct ccgggcgctt tgctgggggc    240

 taaaggggtt tatccctttc cttgaatccc agcaggctag aactaccccc tcccagtctt    300

 caggcttgcc acgctctcca cccgatcctt ccattgaaag gcagagaagg aagg  atg     357
                                                              Met
                                                                1

 tgc ttg gga act tta aga ccc acg aac gac agc gca ctg atg gag cag      405
 Cys Leu Gly Thr Leu Arg Pro Thr Asn Asp Ser Ala Leu Met Glu Gln
               5                  10                  15

 ccc agt gtc tgg ggc aaa gtc ctc gag gtt cat tca ttc agg aag cct      453
 Pro Ser Val Trp Gly Lys Val Leu Glu Val His Ser Phe Arg Lys Pro
          20                  25                  30

 ctg acc agc ctt tac cat gcg ctg agt gag aag ctg agg ata agg aaa      501
 Leu Thr Ser Leu Tyr His Ala Leu Ser Glu Lys Leu Arg Ile Arg Lys
      35                  40                  45

 gag caa gac ccc caa gaa acc ctg atg tct ggc tga aagc cgaagcatga      551
 Glu Gln Asp Pro Gln Glu Thr Leu Met Ser Gly 
  50                  55                  60

 cgcaactttg ctatatttct ctccaacaag gatttgtata ttttcgcttt ctcctcaagt    611

 aacacctgga cctgctcctt tcccttcaaa cgctgagggc tcagtctcca agttccttta    671

 tgaaacaggg tgtaccatca gagacgcagg tatttattga aacctgcttt gtgctgggca    731

 atgtgccaga tgg                                                       744




      <210> 276
      <211> 1427
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (328)..(567)

      <400> 276
 agtgggcgtt tcaaggcgtg cttgccccag gtggtgcagc tctcagaccc tcccacttgt     60

 ttacttcgtg gcgagagggc gaacactgcg cctgcgcact ctccgtagcc ggatccacct    120

 tcagcgtctg cgccacgtga ctccgatcca ccctcgaggt tccagtggaa taaccccctt    180

 ctgaaaaatg gtttcacccg ctccttctct agaacgggtc gggccgctac cactgtccgg    240

 cccggagggg aactgttttc tccggaagtg acaacacgct gactaggaaa aggaggaggc    300

 ggggcagtgg ggccttcggc ggcgact    atg gaa gga gcc ggc tac agg gtg     351
                                  Met Glu Gly Ala Gly Tyr Arg Val
                                    1               5

 gtg ttt gag aag ggc gga gtg tac ctg cac acc agc gct aag aag tat      399
 Val Phe Glu Lys Gly Gly Val Tyr Leu His Thr Ser Ala Lys Lys Tyr
      10                  15                  20

 cag gac cga gac tct ctc atc gct ggt gtc atc cgt gtc gtg gaa aag      447
 Gln Asp Arg Asp Ser Leu Ile Ala Gly Val Ile Arg Val Val Glu Lys
  25                  30                  35                  40

 gac aat gac gtc ctc ctg cac tgg gct cct gta gag gag gct gga gat      495
 Asp Asn Asp Val Leu Leu His Trp Ala Pro Val Glu Glu Ala Gly Asp
                  45                  50                  55

 tcc acc caa atc ctc ttc tcc aag aag gta ggc tcc acc cgc ttt gcc      543
 Ser Thr Gln Ile Leu Phe Ser Lys Lys Val Gly Ser Thr Arg Phe Ala
              60                  65                  70

 ctt ctc cac tcg ctt ttt ttc tag gtccgtgctg ttgtaagtca tttgagggac     597
 Leu Leu His Ser Leu Phe Phe 
          75

 ctgcgtacaa tcccagacct actcgtgggg catgtgtgac cctgtttagg cttgggtact    657

 ctgcctctcc ttttgctcct ctctgtgaaa tgggcagagg atgcccattc aaggaaaaag    717

 agcagggagc ataagacgca cggtcgtggg gacggctgac ccctctctcc ctttgcttct    777

 tgggagatcc ctgccagggt gcaagatgtg gattcgagtt gcttgaaggg aaatggcatt    837

 tcctctggtg ccagaggaca gggcctgaca gcctactcac ccacttcgtc actgctcccg    897

 gctttccctt cgttatgtct cctgggactt cccatggctg gaccccgtcc tgggcaattc    957

 tgagacccag agataagtca gatccagacc cacctaagcc ctgaccctta ctcacttttt   1017

 gagaaactga tagatgaggt cgaaaacgct aggaagtgtt ggaacttttt gcacccagac   1077

 agtctgattc cagatcccca acgcttcctg ggagagcaga catttgagct gggactccca   1137

 ggatatgaaa ggacaagaag gtatttcagg gacagcagaa caaccttcga ggcacacgga   1197

 gatagttgga tgcctctgta aggggggttc tttagtgggg aatgagaact ccattggagc   1257

 tgatgagttc cgcccagggg ccggaagtca gtcggcaccc acagagctag tgactagaca   1317

 cctgggaagg ctgagcttac cacatgcggt tgaccaagca ggagggatga agacgaggat   1377

 gaaggtcgct cataagcttt gctccatggg cagaaacctt aaagggaatt              1427




      <210> 277
      <211> 1184
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (171)..(1184)

      <400> 277
 ccccaattct gcccgggagg ccctctgagg ggctgggccc cagtccccac cttgtccccc     60

 accccggggg tcctgaggct gaagtctggg aggagacaga tgtcaaccgg aacaaactcc    120

 ggatcaacat cggcaaaagc ccctgtgtgg aggaggaaca gagccgaggc   atg ggg     176
                                                          Met Gly
                                                            1

 gtc ccc agc tcc cca gtg cgt gcc ccc cca gac tcc ccc aca acc cca      224
 Val Pro Ser Ser Pro Val Arg Ala Pro Pro Asp Ser Pro Thr Thr Pro
           5                  10                  15

 gtc cgt tct ttg cgc tac cgg agg gtg aac agc cct gag tca gaa agg      272
 Val Arg Ser Leu Arg Tyr Arg Arg Val Asn Ser Pro Glu Ser Glu Arg
      20                  25                  30

 ctg tcc acg gcg gac ggg cga gtg gag cta cct gag agg agg tca cgg      320
 Leu Ser Thr Ala Asp Gly Arg Val Glu Leu Pro Glu Arg Arg Ser Arg
  35                  40                  45                  50

 atg gat ctg cct ggc tcg ccc tcg cgc cag gcc tgc tcc tct cag cca      368
 Met Asp Leu Pro Gly Ser Pro Ser Arg Gln Ala Cys Ser Ser Gln Pro
                  55                  60                  65

 gcc cag atg ctg tca gtg gac aca ggc cac gct gac cga cag gcc agt      416
 Ala Gln Met Leu Ser Val Asp Thr Gly His Ala Asp Arg Gln Ala Ser
              70                  75                  80

 ggc cgc atg gac gtg tca gcc tct gtg gag cag gag gcc ctg agc aac      464
 Gly Arg Met Asp Val Ser Ala Ser Val Glu Gln Glu Ala Leu Ser Asn
          85                  90                  95

 gcc ttc cgc tcg gtg ccg ctg gct gag gag gag gat ttc gac agc aaa      512
 Ala Phe Arg Ser Val Pro Leu Ala Glu Glu Glu Asp Phe Asp Ser Lys
     100                 105                 110

 gag tgg gtc atc atc gac aag gag acg gag ctc aag gac ttc cct cca      560
 Glu Trp Val Ile Ile Asp Lys Glu Thr Glu Leu Lys Asp Phe Pro Pro
 115                 120                 125                 130

 ggg gct gag ccc agc aca tcg ggc acc acg gat gag gag ctc gag gag      608
 Gly Ala Glu Pro Ser Thr Ser Gly Thr Thr Asp Glu Glu Leu Glu Glu
                 135                 140                 145

 ctg cgg cca ctg ccc gag gag ggc gaa gag cgg cgg cgg ctg ggg gca      656
 Leu Arg Pro Leu Pro Glu Glu Gly Glu Glu Arg Arg Arg Leu Gly Ala
             150                 155                 160

 gag ccc acc gtc cgg ccc cgg gga cgc agc atg cag gcg ctg gcg gag      704
 Glu Pro Thr Val Arg Pro Arg Gly Arg Ser Met Gln Ala Leu Ala Glu
         165                 170                 175

 gag gac ctg cag cat ttg ccg ccc cag ccc ctg cca ccc cag ctg agc      752
 Glu Asp Leu Gln His Leu Pro Pro Gln Pro Leu Pro Pro Gln Leu Ser
     180                 185                 190

 cag gcc gat ggc cgt tcc gag acg tca cag ccc ccc acg cct ggc agc      800
 Gln Ala Asp Gly Arg Ser Glu Thr Ser Gln Pro Pro Thr Pro Gly Ser
 195                 200                 205                 210

 cct tcc cac tca ccc ctg cac tcg gga ccc cgc cct cga cgg aga gag      848
 Pro Ser His Ser Pro Leu His Ser Gly Pro Arg Pro Arg Arg Arg Glu
                 215                 220                 225

 tcg gac ccc aca ggc cca cag aga cag ttg gag gag gac aga ctc tcg      896
 Ser Asp Pro Thr Gly Pro Gln Arg Gln Leu Glu Glu Asp Arg Leu Ser
             230                 235                 240

 ggg cac tcc ctc ccg cgg tac agc ccc ctg cga cga ctg gcg tcc tcc      944
 Gly His Ser Leu Pro Arg Tyr Ser Pro Leu Arg Arg Leu Ala Ser Ser
         245                 250                 255

 gtg ttc tcc tcc tcc acg ctg gag acg gag cat tac cct cac ccc ggc      992
 Val Phe Ser Ser Ser Thr Leu Glu Thr Glu His Tyr Pro His Pro Gly
     260                 265                 270

 ggc ggc ggc tcc tcg ggc tcc tcc ggt tcc ctc att cag cgc agc cgc     1040
 Gly Gly Gly Ser Ser Gly Ser Ser Gly Ser Leu Ile Gln Arg Ser Arg
 275                 280                 285                 290

 tcg gct gag agc agc cct gtg cgg gcg ccc cac cgg cgc cac gcg ccc     1088
 Ser Ala Glu Ser Ser Pro Val Arg Ala Pro His Arg Arg His Ala Pro
                 295                 300                 305

 ctc gct gct ggc aac cac aga ctc atg ccc tcg gtg ctc cgc atc tcg     1136
 Leu Ala Ala Gly Asn His Arg Leu Met Pro Ser Val Leu Arg Ile Ser
             310                 315                 320

 cgg tcc cag ctg cag cag gtg tgg gcc cgg ttc acc cac aag acc tag     1184
 Arg Ser Gln Leu Gln Gln Val Trp Ala Arg Phe Thr His Lys Thr 
         325                 330                 335





      <210> 278
      <211> 643
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (63)..(599)

      <400> 278
 atcagctgag cgcgcggcgc gtgtcacgtg gtgtgcgtgt cgaaggtcac ggcgcgctca     60

 ca   atg gag ctc tcg gag tct gtg cag aaa ggc ttc cag atg ctg gcg     107
      Met Glu Leu Ser Glu Ser Val Gln Lys Gly Phe Gln Met Leu Ala
        1               5                  10                  15

 gat ccc cgc tcc ttc gac tcc aac gcc ttc acg ctt ctc ctc cgg gcg      155
 Asp Pro Arg Ser Phe Asp Ser Asn Ala Phe Thr Leu Leu Leu Arg Ala
                  20                  25                  30

 gca ttc cag agt ctg ctg gac gcc cag gcg gac gag gcc gtg tta ggt      203
 Ala Phe Gln Ser Leu Leu Asp Ala Gln Ala Asp Glu Ala Val Leu Gly
              35                  40                  45

 aag ccg ctc ggc tcg gct cgg agc tgg atc cgc cgg ggt gga ggg gcg      251
 Lys Pro Leu Gly Ser Ala Arg Ser Trp Ile Arg Arg Gly Gly Gly Ala
          50                  55                  60

 ctc gga gaa gag gag ccg gcg gag cga gaa ggg gaa agc ccc ggg aag      299
 Leu Gly Glu Glu Glu Pro Ala Glu Arg Glu Gly Glu Ser Pro Gly Lys
      65                  70                  75

 agg aag tct ccg ggc ttt gcc ctt cgc tcc gga cgg agt gtt ggg gac      347
 Arg Lys Ser Pro Gly Phe Ala Leu Arg Ser Gly Arg Ser Val Gly Asp
  80                  85                  90                  95

 gtg gct ctg cca gga ctc gga gca gac tct gag cat tgt ttt ggc ccc      395
 Val Ala Leu Pro Gly Leu Gly Ala Asp Ser Glu His Cys Phe Gly Pro
                 100                 105                 110

 act tgg cac ctg cat aga gcc aac tcc acg ttc ctg gcc cgg ttt ccc      443
 Thr Trp His Leu His Arg Ala Asn Ser Thr Phe Leu Ala Arg Phe Pro
             115                 120                 125

 tcc cag tct ctt tgt tct ttt gta aag ccg gtg ttc aag tct tgt ttg      491
 Ser Gln Ser Leu Cys Ser Phe Val Lys Pro Val Phe Lys Ser Cys Leu
         130                 135                 140

 tgg cct aaa cat cta agg tgt tta gcc ttg tct gag gct gcg gct gtt      539
 Trp Pro Lys His Leu Arg Cys Leu Ala Leu Ser Glu Ala Ala Ala Val
     145                 150                 155

 ttg aca gtt gga ctt cat ctg ggg agc tcc ctg caa ttc aag ctt cca      587
 Leu Thr Val Gly Leu His Leu Gly Ser Ser Leu Gln Phe Lys Leu Pro
 160                 165                 170                 175

 ggg cta ggc tag caa aggtttaagg gtctgtttcc gaagtaatta ctaggtcaga      642
 Gly Leu Gly 


 c                                                                    643




      <210> 279
      <211> 742
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (161)..(673)

      <400> 279
 tggcgaattc ggcacgaggc taggacccag cagcggttgt cgggtttggg gctggaggtg     60

 aagccctgtg tgaatggggt tgattgtccg gcgccacttc cccgcgctgc ccggcagccg    120

 tcttccccag ccgagggact gaactagcca tgatcgcctc  atg tgg agg gca aag     175
                                              Met Trp Arg Ala Lys
                                                1               5

 ttg cgc cgg gga act tgt gag cct gcg gtg aaa ggg tcc cct tct gct      223
 Leu Arg Arg Gly Thr Cys Glu Pro Ala Val Lys Gly Ser Pro Ser Ala
                  10                  15                  20

 tgt tat agc ccc agt agt cct gtc cag gtt cta gaa gac tcc acc tac      271
 Cys Tyr Ser Pro Ser Ser Pro Val Gln Val Leu Glu Asp Ser Thr Tyr
              25                  30                  35

 ttt tcc cca gac ttt cag ctc tat tct ggg agg cat gaa aca tct gct      319
 Phe Ser Pro Asp Phe Gln Leu Tyr Ser Gly Arg His Glu Thr Ser Ala
          40                  45                  50

 ttg acg gtg gag gca acc agt agc atc agg gaa aaa gtt gtt gaa gat      367
 Leu Thr Val Glu Ala Thr Ser Ser Ile Arg Glu Lys Val Val Glu Asp
      55                  60                  65

 cct ctt tgt aac ttc cac tcc cca aac ttc ctg agg atc tca gag gtg      415
 Pro Leu Cys Asn Phe His Ser Pro Asn Phe Leu Arg Ile Ser Glu Val
  70                  75                  80                  85

 gaa atg aga ggt tcc gag gat gcg gca gct gga aca gta ttg cag cgg      463
 Glu Met Arg Gly Ser Glu Asp Ala Ala Ala Gly Thr Val Leu Gln Arg
                  90                  95                 100

 ctg atc cag gaa caa ctg cgg tat ggc acc cca acc gag aac atg aac      511
 Leu Ile Gln Glu Gln Leu Arg Tyr Gly Thr Pro Thr Glu Asn Met Asn
             105                 110                 115

 ttg ctg gcc att cag cac cag gcc aca ggg agt gca gga cca gcc cat      559
 Leu Leu Ala Ile Gln His Gln Ala Thr Gly Ser Ala Gly Pro Ala His
         120                 125                 130

 cct aca aac aac ttt tct tcc acg gaa aac ctc act caa gaa gac cca      607
 Pro Thr Asn Asn Phe Ser Ser Thr Glu Asn Leu Thr Gln Glu Asp Pro
     135                 140                 145

 caa atg gtc tac cag tca gca cgc caa gaa ccg cag ggt caa gaa cac      655
 Gln Met Val Tyr Gln Ser Ala Arg Gln Glu Pro Gln Gly Gln Glu His
 150                 155                 160                 165

 cgg ttg gca ata cgg tga tgggga aaccggcccg gcccagcagc tcaggagaac      709
 Arg Leu Ala Ile Arg 
                 170

 acgaggaact gccccttacg aagaggcaaa gcc                                 742




      <210> 280
      <211> 616
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (26)..(235)

      <400> 280
 tttcgtccta cacatcgcct cttgc  atg caa ctc aca gag agg gag agg caa      52
                              Met Gln Leu Thr Glu Arg Glu Arg Gln
                                1               5

 cct gtc ctc ccc tct ctc agc ctc ggc atc tcc agc cac caa gga cct      100
 Pro Val Leu Pro Ser Leu Ser Leu Gly Ile Ser Ser His Gln Gly Pro
  10                  15                  20                  25

 gct ttt cgc acc tcc aac aac ccc tcc ctt cta ccc tgc cac tcc ctc      148
 Ala Phe Arg Thr Ser Asn Asn Pro Ser Leu Leu Pro Cys His Ser Leu
                  30                  35                  40

 cca gag aga aag gaa aag gag aga gaa aga ttc tgg aat ttg aac cta      196
 Pro Glu Arg Lys Glu Lys Glu Arg Glu Arg Phe Trp Asn Leu Asn Leu
              45                  50                  55

 ccc aaa gag gaa aca tac cca gca aac tca gtt gat taa acatcaaaca       245
 Pro Lys Glu Glu Thr Tyr Pro Ala Asn Ser Val Asp 
          60                  65

 gacatacaga cagatcccaa atcttctgtt caactggaaa ggtcttttct ctggagtcct    305

 gggaggcaag ttatgggcag cactgcttct ggccgcacca tgaagcctga gtctgcttgc    365

 gctctgccca gggccctgct ctgtctgagc attgggcttc tagctgcccc cctccccaca    425

 gcctgccgct gctaggaggt agaactttag gagtggtcct tggcctgttt ctacctgtca    485

 cctggctcac ctcaccactc actcctcctc catcacagca ccccggccct ccctgtccct    545

 ggcctccctg gctggggcat ttgggggtcc gctgggagga gtgcatcgct gaaggcttct    605

 tcctactctc c                                                         616




      <210> 281
      <211> 2816
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (243)..(2537)

      <400> 281
 tttcgtgccg gcggctattt ctattcccag gaaatccccg ggccatctgt gaccaacaaa     60

 ggcccgagcc cccccacccc cgcgagccca acaacagggc ccaacggccc ctggctccgg    120

 ggtgggggga tcgggcctgg atcggctgcc ggtgcctgcc agtgggggtt aggcttgctg    180

 aggggcaggc acaggagtcc tggctgagct catggcctga ggctgcctag cggccacggg    240

 ga   atg gtt gca atg gcg gag gca gag gca ggg gtg gca gtg gag gtc     287
      Met Val Ala Met Ala Glu Ala Glu Ala Gly Val Ala Val Glu Val
        1               5                  10                  15

 cgt gga ctg ccc cct gcc gtg ccc gac gag ctg ctc act ctc tac ttt      335
 Arg Gly Leu Pro Pro Ala Val Pro Asp Glu Leu Leu Thr Leu Tyr Phe
                  20                  25                  30

 gaa aac cgc cga cgc tct gga ggg gga cct gtg ttg agc tgg cag aga      383
 Glu Asn Arg Arg Arg Ser Gly Gly Gly Pro Val Leu Ser Trp Gln Arg
              35                  40                  45

 ctg ggc tgt ggg ggc gtc ctc acc ttc aga gag cct gca gac gcc gag      431
 Leu Gly Cys Gly Gly Val Leu Thr Phe Arg Glu Pro Ala Asp Ala Glu
          50                  55                  60

 agg gtc ttg gcc cag gca gat cac gaa cta cat ggt gcc cag ctg agc      479
 Arg Val Leu Ala Gln Ala Asp His Glu Leu His Gly Ala Gln Leu Ser
      65                  70                  75

 ctg cgg cca gct cca cca cga gcc cct gca cgc ctg ctg ctc caa gga      527
 Leu Arg Pro Ala Pro Pro Arg Ala Pro Ala Arg Leu Leu Leu Gln Gly
  80                  85                  90                  95

 ctg ccc cct ggc acc acg ccc cag cgc ttg gag cag cat gtc cag gcc      575
 Leu Pro Pro Gly Thr Thr Pro Gln Arg Leu Glu Gln His Val Gln Ala
                 100                 105                 110

 ttg ctg cgg gcc tcg ggg ctc cca gta cag cct tgc tgt gcc ttg gcc      623
 Leu Leu Arg Ala Ser Gly Leu Pro Val Gln Pro Cys Cys Ala Leu Ala
             115                 120                 125

 agc ccc cgg cca gac cgg gct ctg gtc cag ttg ccc aag ccc ctt tct      671
 Ser Pro Arg Pro Asp Arg Ala Leu Val Gln Leu Pro Lys Pro Leu Ser
         130                 135                 140

 gag gca gat gtc cgt gtc ctg gag gag cag gcc cag aat ctg ggc ctg      719
 Glu Ala Asp Val Arg Val Leu Glu Glu Gln Ala Gln Asn Leu Gly Leu
     145                 150                 155

 gag ggg acc ttg gtg tcc ctg gcc cgg gtt ccc cag gcc cga gcg gtg      767
 Glu Gly Thr Leu Val Ser Leu Ala Arg Val Pro Gln Ala Arg Ala Val
 160                 165                 170                 175

 cgt gtg gtg ggg gat ggt gcc tct gtg gac ctg ctg ttg ctg gag ttg      815
 Arg Val Val Gly Asp Gly Ala Ser Val Asp Leu Leu Leu Leu Glu Leu
                 180                 185                 190

 tac ctg gag aat gag cgc cgc agt ggt ggg ggg ccc ctg gag gac ctg      863
 Tyr Leu Glu Asn Glu Arg Arg Ser Gly Gly Gly Pro Leu Glu Asp Leu
             195                 200                 205

 caa cgc cta ccc ggg ccc ctg ggc act gtt gcc tcc ttc cag cag tgg      911
 Gln Arg Leu Pro Gly Pro Leu Gly Thr Val Ala Ser Phe Gln Gln Trp
         210                 215                 220

 caa gtg gca gaa cga gtg ttg cag cag gag cac cgg ttg cag ggc tca      959
 Gln Val Ala Glu Arg Val Leu Gln Gln Glu His Arg Leu Gln Gly Ser
     225                 230                 235

 gag ctg agc ctt gtc ccc cac tac gac atc ctg gag ccc gag gag ctg     1007
 Glu Leu Ser Leu Val Pro His Tyr Asp Ile Leu Glu Pro Glu Glu Leu
 240                 245                 250                 255

 gct gag aac acc agt gga ggg gac cac ccg tcc acc cag ggg cct agg     1055
 Ala Glu Asn Thr Ser Gly Gly Asp His Pro Ser Thr Gln Gly Pro Arg
                 260                 265                 270

 gct acc aag cat gct ctc ctg agg acc gga ggg ttg gtg acg gct ctg     1103
 Ala Thr Lys His Ala Leu Leu Arg Thr Gly Gly Leu Val Thr Ala Leu
             275                 280                 285

 cag ggt gca ggg act gtg aca atg ggc tct ggc gag gaa cca ggg cag     1151
 Gln Gly Ala Gly Thr Val Thr Met Gly Ser Gly Glu Glu Pro Gly Gln
         290                 295                 300

 tca ggg gcc tct ctg agg aca ggt ccc atg gtg cag ggt aga ggg att     1199
 Ser Gly Ala Ser Leu Arg Thr Gly Pro Met Val Gln Gly Arg Gly Ile
     305                 310                 315

 atg aca aca ggc tct ggc cag gaa cca ggg cag tca ggg acc tct ctg     1247
 Met Thr Thr Gly Ser Gly Gln Glu Pro Gly Gln Ser Gly Thr Ser Leu
 320                 325                 330                 335

 agg aca ggt ccc atg ggg tct ctg gga cag gca gag caa gtc agc tcg     1295
 Arg Thr Gly Pro Met Gly Ser Leu Gly Gln Ala Glu Gln Val Ser Ser
                 340                 345                 350

 atg ccc atg ggg tct ctg gaa cat gag ggg ctg gta agc ctg agg cct     1343
 Met Pro Met Gly Ser Leu Glu His Glu Gly Leu Val Ser Leu Arg Pro
             355                 360                 365

 gtg ggg ttg cag gaa cag gag ggg ccc atg agc ctg ggg cct gtg ggg     1391
 Val Gly Leu Gln Glu Gln Glu Gly Pro Met Ser Leu Gly Pro Val Gly
         370                 375                 380

 tct gca ggc cca gtg gag acc tct aag ggg ttg ctg ggg cag gag ggc     1439
 Ser Ala Gly Pro Val Glu Thr Ser Lys Gly Leu Leu Gly Gln Glu Gly
     385                 390                 395

 ctg gtg gaa att gcc atg gac tca cca gag caa gag ggg ctg gtg ggt     1487
 Leu Val Glu Ile Ala Met Asp Ser Pro Glu Gln Glu Gly Leu Val Gly
 400                 405                 410                 415

 ccc atg gag atc acc atg ggg tct ctg gag aag gca ggg cct gtg agc     1535
 Pro Met Glu Ile Thr Met Gly Ser Leu Glu Lys Ala Gly Pro Val Ser
                 420                 425                 430

 cca gga tgt gtg aag ctg gca ggg cag gag ggc ctg gtg gag atg gtg     1583
 Pro Gly Cys Val Lys Leu Ala Gly Gln Glu Gly Leu Val Glu Met Val
             435                 440                 445

 cta ttg atg gag cca ggg gcg atg cgc ttc ctg cag ctc tac cat gag     1631
 Leu Leu Met Glu Pro Gly Ala Met Arg Phe Leu Gln Leu Tyr His Glu
         450                 455                 460

 gac ctt ctt gcg ggc ctg gga gac gtc gct ctc ttg cca ctt gaa gga     1679
 Asp Leu Leu Ala Gly Leu Gly Asp Val Ala Leu Leu Pro Leu Glu Gly
     465                 470                 475

 ccg gat atg act ggc ttt cgg ctc tgt gga gcc cag gct tcc tgc cag     1727
 Pro Asp Met Thr Gly Phe Arg Leu Cys Gly Ala Gln Ala Ser Cys Gln
 480                 485                 490                 495

 gcg gct gag gag ttt ctg cgg agc ctg ctg ggc agc att agc tgc cat     1775
 Ala Ala Glu Glu Phe Leu Arg Ser Leu Leu Gly Ser Ile Ser Cys His
                 500                 505                 510

 gtg ttg tgc ctg gag cac ccg ggc agc gcc agg ttt ctc ctg ggc cca     1823
 Val Leu Cys Leu Glu His Pro Gly Ser Ala Arg Phe Leu Leu Gly Pro
             515                 520                 525

 gaa ggg cag cac ctt ctc cag ggg ctg gag gct cag ttc cag tgt gtc     1871
 Glu Gly Gln His Leu Leu Gln Gly Leu Glu Ala Gln Phe Gln Cys Val
         530                 535                 540

 ttt ggg aca gag cgc ctg gcc aca gcc acg ttg gac aca ggc ctt gaa     1919
 Phe Gly Thr Glu Arg Leu Ala Thr Ala Thr Leu Asp Thr Gly Leu Glu
     545                 550                 555

 gag gtg gac cct acc gag gcc ctc cca gtg ctc cct ggc aac gcc cac     1967
 Glu Val Asp Pro Thr Glu Ala Leu Pro Val Leu Pro Gly Asn Ala His
 560                 565                 570                 575

 acc ctg tgg acc cca gac agt aca ggt ggt gac cag gag gac gtg agc     2015
 Thr Leu Trp Thr Pro Asp Ser Thr Gly Gly Asp Gln Glu Asp Val Ser
                 580                 585                 590

 ctg gag gag gtc cga gaa ctg ctg gcc acc ctg gag ggc cta gac cta     2063
 Leu Glu Glu Val Arg Glu Leu Leu Ala Thr Leu Glu Gly Leu Asp Leu
             595                 600                 605

 gac ggg gag gac tgg ctg cct cgg gag ctg gag gag gaa ggg cct cag     2111
 Asp Gly Glu Asp Trp Leu Pro Arg Glu Leu Glu Glu Glu Gly Pro Gln
         610                 615                 620

 gag cag cca gag gag gag gtg acc cca ggg cat gag gag gag gag cct     2159
 Glu Gln Pro Glu Glu Glu Val Thr Pro Gly His Glu Glu Glu Glu Pro
     625                 630                 635

 gtg gcc ccc agc act gtg gca ccc agg tgg ctg gag gag gag gcc gct     2207
 Val Ala Pro Ser Thr Val Ala Pro Arg Trp Leu Glu Glu Glu Ala Ala
 640                 645                 650                 655

 ctg cag ctg gcc ctc cac cgg tca ctg gag cct caa ggt cag gtg gct     2255
 Leu Gln Leu Ala Leu His Arg Ser Leu Glu Pro Gln Gly Gln Val Ala
                 660                 665                 670

 gag cag gag gag gct gct gcc ctg cgg caa gcc cta acc ctc tcc ctg     2303
 Glu Gln Glu Glu Ala Ala Ala Leu Arg Gln Ala Leu Thr Leu Ser Leu
             675                 680                 685

 ctg gag cag ccc ccg ttg gag gca gaa gag ccc cca gat ggg ggg act     2351
 Leu Glu Gln Pro Pro Leu Glu Ala Glu Glu Pro Pro Asp Gly Gly Thr
         690                 695                 700

 gat ggc aag gcc cag ctg gtg gtg cac tcg gcc ttt gag cag gat gtg     2399
 Asp Gly Lys Ala Gln Leu Val Val His Ser Ala Phe Glu Gln Asp Val
     705                 710                 715

 gag gag ctg gac cgg gcg ctc agg gct gcc ttg gag gtc cac gtc cag     2447
 Glu Glu Leu Asp Arg Ala Leu Arg Ala Ala Leu Glu Val His Val Gln
 720                 725                 730                 735

 gag gag acg gtg ggg ccc tgg cgc cgc aca ctg cct gca gag ctg cgt     2495
 Glu Glu Thr Val Gly Pro Trp Arg Arg Thr Leu Pro Ala Glu Leu Arg
                 740                 745                 750

 gct cgc ctg gag cgg tgc cat ggt tgg cgg ggc aga cgc tga aggggcc     2544
 Ala Arg Leu Glu Arg Cys His Gly Trp Arg Gly Arg Arg 
             755                 760

 ctggaacaac ctggagcgtc tggcagagaa caccggggag ttccaggagg tggtgcgggc   2604

 cttctacgac accctggacg ctgcccgcag cagcatccgc gtcgttcgtg tggagcgcgt   2664

 gtcgcacccg ctgctgcagc agcagtatga gctgtaccgg gagcgcctgc tgcagcgatg   2724

 cgagcggcgc ccggtggagc aggtgctgta ccacggcacg acggcaccgg cagtgcctga   2784

 catctgcgcc cacggcttca accgcagctt ct                                 2816




      <210> 282
      <211> 1076
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (36)..(383)

      <400> 282
 ggtatttaaa aggatactcg tccgagggca ggact   atg gga ggc tgc cct gta      53
                                          Met Gly Gly Cys Pro Val
                                            1               5

 cgg aaa aga aga aga aat ggc agt aaa gag ggc aac cat cat tcc acc      101
 Arg Lys Arg Arg Arg Asn Gly Ser Lys Glu Gly Asn His His Ser Thr
              10                  15                  20

 cag ccc aaa agg aat aag aga aac cct atc ttt cag gat tct caa gat      149
 Gln Pro Lys Arg Asn Lys Arg Asn Pro Ile Phe Gln Asp Ser Gln Asp
          25                  30                  35

 aca gag ttt tca tgg agt gat aat gaa agg agc agc agc cgc att aat      197
 Thr Glu Phe Ser Trp Ser Asp Asn Glu Arg Ser Ser Ser Arg Ile Asn
      40                  45                  50

 atc cca gag aga gca agt gga cca gaa ggc aac tta aac cag att gtt      245
 Ile Pro Glu Arg Ala Ser Gly Pro Glu Gly Asn Leu Asn Gln Ile Val
  55                  60                  65                  70

 act gaa ccc gat gca aac ttt ccc cag ttc ttg cat gag gga ttg tct      293
 Thr Glu Pro Asp Ala Asn Phe Pro Gln Phe Leu His Glu Gly Leu Ser
                  75                  80                  85

 aaa cct gtt tat gtc ata aac tgg ttt atg tcc ttt ggt cct gaa ata      341
 Lys Pro Val Tyr Val Ile Asn Trp Phe Met Ser Phe Gly Pro Glu Ile
              90                  95                 100

 aaa ctc aat act tca cag cag gga agg aac caa gct gtt taa aactact      390
 Lys Leu Asn Thr Ser Gln Gln Gly Arg Asn Gln Ala Val 
         105                 110                 115

 tatctccgct atgaaggaga agtattttca aggaatatca gaagaaagta gaaagtgaga    450

 ggaggttcca agtgggcttt ccctgggtcc aagaggggcc tcaaaaactt gtgaaactca    510

 ctcatttcct gcagcgggac ttacttttgg tcctggatga ataatattga agatatgtgc    570

 ttaaaacatt cctaacatca gaatttgcgc ctgtgttttc ttccccaaga aagctataaa    630

 cagcgaaaat tttgttgtaa gcttccctgt gtcctctctc cctctctccc ttccccctcc    690

 cctgaaacta aaaggaatgt taaaagccca cttttctgtg accagcagac cttatctatg    750

 gtcccaattc caattccttg taaacacaat ttgtaaaatc ccgtgagatc ctgtctcctt    810

 tgccatcccg ctgcaaggtt ataagtagag aaaacttaag ttacaattcc agttttcctc    870

 aagatctgag acatgttaat tgtctttgtt tctccctctg gtaacatctt cccaccacac    930

 atatttcctg ccttagagag tttaaaaggt gataaaaaaa tctaacactg gctaccccgc    990

 tcgggacccc ttccacgctg tgaaagcttt gtactgtcac tctgcttaat aaagcctaca   1050

 gcttttttac tctcaaaaaa aaaaaa                                        1076




      <210> 283
      <211> 964
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (131)..(679)

      <400> 283
 gcacaagcaa gggctgccct gaaggaagct ccaaagagaa aggagggcag gaagcccacg     60

 gcccacaggg gtgtagcccg agacccacct gcagccccca gcccttgcca ggaaagcagc    120

 agccgcagcc   atg gcg ggg atg aag aca gcc tcc ggg gac tac atc gac     169
              Met Ala Gly Met Lys Thr Ala Ser Gly Asp Tyr Ile Asp
                1               5                  10

 tcg tca tgg gag ctg cgg gtg ttt gtg gga gag gag gac cca gag gcc      217
 Ser Ser Trp Glu Leu Arg Val Phe Val Gly Glu Glu Asp Pro Glu Ala
      15                  20                  25

 gag tcg gtc acc ctg cgg gtc act ggg gag tcg cac atc ggc ggg gtg      265
 Glu Ser Val Thr Leu Arg Val Thr Gly Glu Ser His Ile Gly Gly Val
  30                  35                  40                  45

 ctc ctg aag att gtg gag cag atc aat cgc aag cag gac tgg tca gac      313
 Leu Leu Lys Ile Val Glu Gln Ile Asn Arg Lys Gln Asp Trp Ser Asp
                  50                  55                  60

 cat gct att tgg tgg gaa cag aag agg cag tgg ctg ctg cag acc cac      361
 His Ala Ile Trp Trp Glu Gln Lys Arg Gln Trp Leu Leu Gln Thr His
              65                  70                  75

 tgg aca ctg gac aag tac ggg atc ctg gcc gac gca cgc ctc ttc ttt      409
 Trp Thr Leu Asp Lys Tyr Gly Ile Leu Ala Asp Ala Arg Leu Phe Phe
          80                  85                  90

 ggg ccc cag cac cgg ccc gtc atc ctt cgg ttg ccc aac cgc cgc gca      457
 Gly Pro Gln His Arg Pro Val Ile Leu Arg Leu Pro Asn Arg Arg Ala
      95                 100                 105

 ctg cgc ctc cgt gcc agc ttc tcc cag ccc ctc ttc cag gct gtg gct      505
 Leu Arg Leu Arg Ala Ser Phe Ser Gln Pro Leu Phe Gln Ala Val Ala
 110                 115                 120                 125

 gcc atc tgc cgc ctc ctc agc atc cgg cac ccc gag gag ctg tcc ctg      553
 Ala Ile Cys Arg Leu Leu Ser Ile Arg His Pro Glu Glu Leu Ser Leu
                 130                 135                 140

 ctc cgg gct cct gag aag aag gag aag aag aag aaa gag aag gag cca      601
 Leu Arg Ala Pro Glu Lys Lys Glu Lys Lys Lys Lys Glu Lys Glu Pro
             145                 150                 155

 gag gaa gag ctc tat gac ttg agc aag gtt gtc ttg gct ggg ggc gtg      649
 Glu Glu Glu Leu Tyr Asp Leu Ser Lys Val Val Leu Ala Gly Gly Val
         160                 165                 170

 gca cct gca ctg ttc cgg ggg atg tcc tag c tcacttctcg gacagcgcca      700
 Ala Pro Ala Leu Phe Arg Gly Met Ser 
     175                 180

 gactgaggcc tgttaccaca tgctgagccg gcccaagacg gcaccgaacc ctactgctcc    760

 agcgctggca gggccagtcc ctgtcagaag acccagtcca agcagtggcg ggccgaccga    820

 gcacagacac ggcaaggggg gcacccgggc ggtcaactca tgtcaccacc cgcgcgcatt    880

 aacagactag aagaccatat ctcctccccg tcgccggcgc cgccgcctcc tcccctcaca    940

 acaaaaacac aacacaaaca cgac                                           964




      <210> 284
      <211> 713
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (174)..(662)

      <400> 284
 tttcgtaaca ggagcagaga cttcccaagc agcccctgtc tcagggccag ggaagcacac     60

 ccagacgaca aggacacaga gcagggagac acagggtccc cctgcctgtg ccccgggtga    120

 ccctgccatg ggctgaagtc tccactgtgg tgtggtccat tgtctcaggc tcc   atg     176
                                                              Met
                                                                1

 gat act gga att acc cag aca cca aaa tac ctg gtc aca gca atg ggg      224
 Asp Thr Gly Ile Thr Gln Thr Pro Lys Tyr Leu Val Thr Ala Met Gly
               5                  10                  15

 agt aaa agg aca atg aaa cgt gag cat ctg gga cat gat tct atg tat      272
 Ser Lys Arg Thr Met Lys Arg Glu His Leu Gly His Asp Ser Met Tyr
          20                  25                  30

 tgg tac aga cag aaa gct aag aaa tcc ctg gag ttc atg ttt tac tac      320
 Trp Tyr Arg Gln Lys Ala Lys Lys Ser Leu Glu Phe Met Phe Tyr Tyr
      35                  40                  45

 aac tgt aag gaa ttc att gaa aac aag act gtg cca aat cac ttc aca      368
 Asn Cys Lys Glu Phe Ile Glu Asn Lys Thr Val Pro Asn His Phe Thr
  50                  55                  60                  65

 cct gaa tgc cct gac agc tct cgc tta tac ctt cat gtg gtc gca ctg      416
 Pro Glu Cys Pro Asp Ser Ser Arg Leu Tyr Leu His Val Val Ala Leu
                  70                  75                  80

 cag caa gaa gac tca gct gcg tat ctc tgc acc agc agc caa gac aca      464
 Gln Gln Glu Asp Ser Ala Ala Tyr Leu Cys Thr Ser Ser Gln Asp Thr
              85                  90                  95

 gcc ctg cag agt cac cgc ctc cct gtg cac aaa cct cct gga tct aat      512
 Ala Leu Gln Ser His Arg Leu Pro Val His Lys Pro Pro Gly Ser Asn
         100                 105                 110

 cag aaa acc gtg ggg gca acg cat cca gct gag cct cag cac tcg gtt      560
 Gln Lys Thr Val Gly Ala Thr His Pro Ala Glu Pro Gln His Ser Val
     115                 120                 125

 cag cat tct gta aga cct cag cag aca tct cag atc ata ata ctg tca      608
 Gln His Ser Val Arg Pro Gln Gln Thr Ser Gln Ile Ile Ile Leu Ser
 130                 135                 140                 145

 ttt att gga tgt ggc aat gct aaa ttg ccc aga ctc ctg cag cct gtg      656
 Phe Ile Gly Cys Gly Asn Ala Lys Leu Pro Arg Leu Leu Gln Pro Val
                 150                 155                 160

 gcc tga gtttgtcttg aatgagactg tgcctgaact tgaatgtagg acagatgccg       712
 Ala 


 t                                                                    713




      <210> 285
      <211> 729
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (141)..(584)

      <400> 285
 gttttttcac tgctttctca acagttcctg tgaataaatg aaacatttcg gagctccctg     60

 agagcaagag ccttcacttc ttcttgcggt gccgggacca tgtgttggtg aagctggtgc    120

 tgtgggggcc actcactcga    atg aca cct gga ggc ctg ttc ctc cct tac     170
                          Met Thr Pro Gly Gly Leu Phe Leu Pro Tyr
                            1               5                  10

 cac tcc ctt ccc cag ccc gac ttc ttg gcc tcc tgc cca acc aga cac      218
 His Ser Leu Pro Gln Pro Asp Phe Leu Ala Ser Cys Pro Thr Arg His
                  15                  20                  25

 ctc aaa ctc tgt cag cgc cct ggc att ctg gca gag aat cct cac cag      266
 Leu Lys Leu Cys Gln Arg Pro Gly Ile Leu Ala Glu Asn Pro His Gln
              30                  35                  40

 ttc tca cca acc ttc ccc cca ggc aag ggc agc tgc cag cat ggt gct      314
 Phe Ser Pro Thr Phe Pro Pro Gly Lys Gly Ser Cys Gln His Gly Ala
          45                  50                  55

 ctg cca gga cag gtt tcc ctg aag gaa gct gct cac act gag atg agc      362
 Leu Pro Gly Gln Val Ser Leu Lys Glu Ala Ala His Thr Glu Met Ser
      60                  65                  70

 ctc tca ggg cag gac ctc ttc cca agc cct gca cac cca ccc ctg cag      410
 Leu Ser Gly Gln Asp Leu Phe Pro Ser Pro Ala His Pro Pro Leu Gln
  75                  80                  85                  90

 ccc ttt tgg ctc ccc ttt tcc ctg tgc ctc agc act cct ttc ctg gtt      458
 Pro Phe Trp Leu Pro Phe Ser Leu Cys Leu Ser Thr Pro Phe Leu Val
                  95                 100                 105

 gca gat aac gaa cta agg ttg cct aaa ggg cag atc tgc cct ctc cat      506
 Ala Asp Asn Glu Leu Arg Leu Pro Lys Gly Gln Ile Cys Pro Leu His
             110                 115                 120

 gtc ttc gtc ctg gca aac agg gtc gtc tta aaa tta tgc gct aat tct      554
 Val Phe Val Leu Ala Asn Arg Val Val Leu Lys Leu Cys Ala Asn Ser
         125                 130                 135

 gta tgg gag cac tca aaa ggc att act tag a gattgaaatt tcaaactatc      605
 Val Trp Glu His Ser Lys Gly Ile Thr 
     140                 145

 tctagttttt caatggaaat atatcagcta gggaaaaacc atcaagctca ttattatttt    665

 ttgatcttca gttgtatttt tgtgaatatt ttaatacatc tttttcaatt tcaaaaaaaa    725

 aaaa                                                                 729




      <210> 286
      <211> 655
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(570)

      <400> 286
 gacaattttc gtttttctac tgccctttcg ggccaggggt tattttatga gcatctccga     60

 tgttgcacac gtggcgtgtg aaccgagaga aagaag  atg gag aga tca ccc tcc     114
                                          Met Glu Arg Ser Pro Ser
                                            1               5

 aga cgt cgt cgc ctg gaa gag gcc cca aaa ttg cca tat aag aac cca      162
 Arg Arg Arg Arg Leu Glu Glu Ala Pro Lys Leu Pro Tyr Lys Asn Pro
              10                  15                  20

 aca cac ctt gct cag cag cag gaa ccc tgg agt cgg ctc aac tca acc      210
 Thr His Leu Ala Gln Gln Gln Glu Pro Trp Ser Arg Leu Asn Ser Thr
          25                  30                  35

 ccc aca att act tcc atg agg cgg gat gcc tac tat ttt gat ccc gag      258
 Pro Thr Ile Thr Ser Met Arg Arg Asp Ala Tyr Tyr Phe Asp Pro Glu
      40                  45                  50

 ata cca aag gat gac ctg gac ttc cgc tta gca gcc ttg tac aac cac      306
 Ile Pro Lys Asp Asp Leu Asp Phe Arg Leu Ala Ala Leu Tyr Asn His
  55                  60                  65                  70

 cac act ggg aca ttc aag aac aaa agt gag ata ctg tta aac cag aaa      354
 His Thr Gly Thr Phe Lys Asn Lys Ser Glu Ile Leu Leu Asn Gln Lys
                  75                  80                  85

 acc acg cag gat acc tat aga acc aag atc caa ttc cct gga gaa ttt      402
 Thr Thr Gln Asp Thr Tyr Arg Thr Lys Ile Gln Phe Pro Gly Glu Phe
              90                  95                 100

 tta acc cct ccc act cca ccc atc act ttc ctg gct aac atc aga cac      450
 Leu Thr Pro Pro Thr Pro Pro Ile Thr Phe Leu Ala Asn Ile Arg His
         105                 110                 115

 tgg atc aac cct aaa aag gag tcc atc cac agc atc caa gga tcc ata      498
 Trp Ile Asn Pro Lys Lys Glu Ser Ile His Ser Ile Gln Gly Ser Ile
     120                 125                 130

 gtg tcc cct cac act gca gcc acc aat gga ggc tac tcc cga aag aaa      546
 Val Ser Pro His Thr Ala Ala Thr Asn Gly Gly Tyr Ser Arg Lys Lys
 135                 140                 145                 150

 gat ggt ggc ttc ttc tcc acc tag tgttgacaga tccctgaact aattatagtg     600
 Asp Gly Gly Phe Phe Ser Thr 
                 155

 aaacatactg cggcccactt ccattaaata gatttgtgca agaaaaaaaa aaaaa         655




      <210> 287
      <211> 998
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (153)..(947)

      <400> 287
 ttctgcccgg atggaagctc cggccgcgga gtgatggtgg cctcagcgaa gatgggccgg     60

 gcagggacca tggcggtggc agcagaggtg gcaggggcgg ggcggctggc ggtagaggag    120

 gctgtggtcc tcagggggct gtaggtggag gt  atg gct cgg gcc agc agc ggg     173
                                      Met Ala Arg Ala Ser Ser Gly
                                        1               5

 aac ggc agc gag gag gcc tgg ggg gca ctt cgg gcg ccg caa cag cag      221
 Asn Gly Ser Glu Glu Ala Trp Gly Ala Leu Arg Ala Pro Gln Gln Gln
          10                  15                  20

 ctt cga gag ctg tgc cca gga gtg aac aac cag ccc tac ctc tgt gag      269
 Leu Arg Glu Leu Cys Pro Gly Val Asn Asn Gln Pro Tyr Leu Cys Glu
      25                  30                  35

 agt ggt cac tgc tgc ggg gag act ggc tgc tgc acc tac tac tat gag      317
 Ser Gly His Cys Cys Gly Glu Thr Gly Cys Cys Thr Tyr Tyr Tyr Glu
  40                  45                  50                  55

 ctc tgg tgg ttc tgg ctg ctc tgg act gtc ctc atc ctc ttt agc tgc      365
 Leu Trp Trp Phe Trp Leu Leu Trp Thr Val Leu Ile Leu Phe Ser Cys
                  60                  65                  70

 tgt tgc gcc ttc cgc cac cga cga gct aaa ctc agg ctg caa caa cag      413
 Cys Cys Ala Phe Arg His Arg Arg Ala Lys Leu Arg Leu Gln Gln Gln
              75                  80                  85

 cag cgg cag cgt gaa atc aac ttg ttg gcc tat cat ggg gca tgc cat      461
 Gln Arg Gln Arg Glu Ile Asn Leu Leu Ala Tyr His Gly Ala Cys His
          90                  95                 100

 ggg gct ggt cct ttc cct acc ggt tca ctg ctt gac ctt cgc ttc ctc      509
 Gly Ala Gly Pro Phe Pro Thr Gly Ser Leu Leu Asp Leu Arg Phe Leu
     105                 110                 115

 agc acc ttc aag ccc cca gcc tac gag gat gtg gtt cac cgc cca ggc      557
 Ser Thr Phe Lys Pro Pro Ala Tyr Glu Asp Val Val His Arg Pro Gly
 120                 125                 130                 135

 aca cca ccc ccc cct tat act gtg gcc cca ggc cgc ccc ttg act gct      605
 Thr Pro Pro Pro Pro Tyr Thr Val Ala Pro Gly Arg Pro Leu Thr Ala
                 140                 145                 150

 tcc agt gaa caa acc tgc tgt tcc tcc tca tcc agc tgc cct gcc cac      653
 Ser Ser Glu Gln Thr Cys Cys Ser Ser Ser Ser Ser Cys Pro Ala His
             155                 160                 165

 ttt gaa gga aca aat gtg gaa ggt gtt tcc tcc cac cag agt gcc ccc      701
 Phe Glu Gly Thr Asn Val Glu Gly Val Ser Ser His Gln Ser Ala Pro
         170                 175                 180

 ccc cat cag gag ggt gag ccc ggg gca ggg gtg acc cct gcc tcc aca      749
 Pro His Gln Glu Gly Glu Pro Gly Ala Gly Val Thr Pro Ala Ser Thr
     185                 190                 195

 ccc ccc tcc tgc cgc tat cgc cgt tta act ggc gac tcc ggt att gag      797
 Pro Pro Ser Cys Arg Tyr Arg Arg Leu Thr Gly Asp Ser Gly Ile Glu
 200                 205                 210                 215

 ctc tgc cct tgt cct gcc tcc ggt gag ggt gag cca gtc aag gag gtg      845
 Leu Cys Pro Cys Pro Ala Ser Gly Glu Gly Glu Pro Val Lys Glu Val
                 220                 225                 230

 agg gtt agt gcc acc ctg cca gat ctg gag gac tac tcc ccc gtg tgc      893
 Arg Val Ser Ala Thr Leu Pro Asp Leu Glu Asp Tyr Ser Pro Val Cys
             235                 240                 245

 act acc ccc aga gtc tgt acc gca gat ctt tcc cat ggg gct gtc ttc      941
 Thr Thr Pro Arg Val Cys Thr Ala Asp Leu Ser His Gly Ala Val Phe
         250                 255                 260

 cag tga aggggacatc ccataagtag ttttgagagg gtggatgggt tacttgccca       997
 Gln 


 c                                                                    998




      <210> 288
      <211> 1305
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (29)..(1111)

      <400> 288
 agactggacc tactgattca acttggag   atg agc ggg tct gtc ctc ttc acg      52
                                  Met Ser Gly Ser Val Leu Phe Thr
                                    1               5

 gcg gga gag agg tgg aga tgc ttt ctg acc ccg tcg agg tca tcc ctg      100
 Ala Gly Glu Arg Trp Arg Cys Phe Leu Thr Pro Ser Arg Ser Ser Leu
      10                  15                  20

 tac tgg gcc tta cat aat ttc tgc tgt cgg aaa aaa tcc act aca cct      148
 Tyr Trp Ala Leu His Asn Phe Cys Cys Arg Lys Lys Ser Thr Thr Pro
  25                  30                  35                  40

 aag aaa att act ccc aat gtt act ttt tgt gat gaa aat gca aag gag      196
 Lys Lys Ile Thr Pro Asn Val Thr Phe Cys Asp Glu Asn Ala Lys Glu
                  45                  50                  55

 ccc gaa aat gca ctt gac aag ctc ttc tct tca gaa cag cag gct tcc      244
 Pro Glu Asn Ala Leu Asp Lys Leu Phe Ser Ser Glu Gln Gln Ala Ser
              60                  65                  70

 atc ttg cat gtg ttg aat aca gca tct act aaa gaa ctt gaa gct ttc      292
 Ile Leu His Val Leu Asn Thr Ala Ser Thr Lys Glu Leu Glu Ala Phe
          75                  80                  85

 cga ttg ctt cgt gga aga agg tcc atc aat atc gta gag cac aga gaa      340
 Arg Leu Leu Arg Gly Arg Arg Ser Ile Asn Ile Val Glu His Arg Glu
      90                  95                 100

 aac ttt ggg cca ttt cag aat tta gag agt tta atg aat gtg ccc ttg      388
 Asn Phe Gly Pro Phe Gln Asn Leu Glu Ser Leu Met Asn Val Pro Leu
 105                 110                 115                 120

 ttt aag tat aaa agt aca gtt caa gtt tgt aac tcc ata ctt tgt cca      436
 Phe Lys Tyr Lys Ser Thr Val Gln Val Cys Asn Ser Ile Leu Cys Pro
                 125                 130                 135

 aag act gga cgg gaa aaa aga aag tca ccg gaa aac cgg ttc ctg aga      484
 Lys Thr Gly Arg Glu Lys Arg Lys Ser Pro Glu Asn Arg Phe Leu Arg
             140                 145                 150

 aag ctc ctc aaa cca gac ata gaa aga gaa aga ctt aag gca gtt aat      532
 Lys Leu Leu Lys Pro Asp Ile Glu Arg Glu Arg Leu Lys Ala Val Asn
         155                 160                 165

 agt atc ata tct atc gtt ttt ggt act cga aga att gcc tgg gct cac      580
 Ser Ile Ile Ser Ile Val Phe Gly Thr Arg Arg Ile Ala Trp Ala His
     170                 175                 180

 ctt gat cgt aag ttg aca gtg ctg gac tgg cag caa agt gac cgt tgg      628
 Leu Asp Arg Lys Leu Thr Val Leu Asp Trp Gln Gln Ser Asp Arg Trp
 185                 190                 195                 200

 agt tta atg aga gga ata tac tca tca tca gtc tat tta gaa gag att      676
 Ser Leu Met Arg Gly Ile Tyr Ser Ser Ser Val Tyr Leu Glu Glu Ile
                 205                 210                 215

 tcc tcg atc att tca aag atg cct aaa gca gat ttc tat gtt ctg gaa      724
 Ser Ser Ile Ile Ser Lys Met Pro Lys Ala Asp Phe Tyr Val Leu Glu
             220                 225                 230

 aaa aca gga ctt tcc att cag aac tca tct ctg ttt cca ata ctg tta      772
 Lys Thr Gly Leu Ser Ile Gln Asn Ser Ser Leu Phe Pro Ile Leu Leu
         235                 240                 245

 cat ttt cat atc atg gaa gcc atg ctg tat gcc tta tta aat aaa act      820
 His Phe His Ile Met Glu Ala Met Leu Tyr Ala Leu Leu Asn Lys Thr
     250                 255                 260

 ttt gcc cag gat ggg cag cat cag gtg ctg agc atg aat cga aat gca      868
 Phe Ala Gln Asp Gly Gln His Gln Val Leu Ser Met Asn Arg Asn Ala
 265                 270                 275                 280

 gtg ggg aag cat ttt gaa ctg atg att ggt gac tcc cgg act agt gga      916
 Val Gly Lys His Phe Glu Leu Met Ile Gly Asp Ser Arg Thr Ser Gly
                 285                 290                 295

 aaa gag cta gtg aag cag ttt ctc ttc gat tct ata ctg aag gcg gat      964
 Lys Glu Leu Val Lys Gln Phe Leu Phe Asp Ser Ile Leu Lys Ala Asp
             300                 305                 310

 cct cgg gtg ttc ttc cca tca gat aaa ata gtt cac tac aga cag atg     1012
 Pro Arg Val Phe Phe Pro Ser Asp Lys Ile Val His Tyr Arg Gln Met
         315                 320                 325

 ttt tta tct act gaa cta caa aga gta gaa gag ctt tat gat tca tta     1060
 Phe Leu Ser Thr Glu Leu Gln Arg Val Glu Glu Leu Tyr Asp Ser Leu
     330                 335                 340

 tta caa gct att gcc ttc tat gaa tta gca gtg ttt gac tct cag cct     1108
 Leu Gln Ala Ile Ala Phe Tyr Glu Leu Ala Val Phe Asp Ser Gln Pro
 345                 350                 355                 360

 tag aatt ctgaggttaa cgtgctaaag tataattatt agctctaacg taacaccaac     1165
 


 tgttgtgaac atccatgtta ttggaaaaga acacattttc agtgtatttt agatgtttaa   1225

 attctgactt ttggctatta aatggtttac acaataagcc aagaccaaat caataaacat   1285

 tttatgagaa aaaaaaaaaa                                               1305




      <210> 289
      <211> 1419
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (219)..(458)

      <400> 289
 tttcgtacga aatcaggccg cgccaagggc ggtggtggct gctgctctgg ctgccgcccc     60

 tggccacact gcccgtgcgc ggggaggcgg cggcggcagc gttatcagtt cgtaggtgta    120

 aagctttgaa ggaaaaagat ttaattagaa cgtctgagtc agactgttac tgctacaatc    180

 aaaattccca agtggagtgg aaatacatat ggtcaact    atg cag gtg aaa att     233
                                              Met Gln Val Lys Ile
                                                1               5

 acc agt cca ggc ctg ttc aga att gta tat atc gca gaa aga cat aat      281
 Thr Ser Pro Gly Leu Phe Arg Ile Val Tyr Ile Ala Glu Arg His Asn
                  10                  15                  20

 tgc caa tat cca gaa aac att cta tct ttt atc aaa tgt gtg att cat      329
 Cys Gln Tyr Pro Glu Asn Ile Leu Ser Phe Ile Lys Cys Val Ile His
              25                  30                  35

 aac ttt tgg ata cca aag gaa tct aac gaa ata acc ata atc atc aat      377
 Asn Phe Trp Ile Pro Lys Glu Ser Asn Glu Ile Thr Ile Ile Ile Asn
          40                  45                  50

 cca tac agg gag act gtg tgc ttc tct gtg gag cct gtc aag aag act      425
 Pro Tyr Arg Glu Thr Val Cys Phe Ser Val Glu Pro Val Lys Lys Thr
      55                  60                  65

 ctg caa tac tct tcc tat agt tcg tca gta taa gtccttaa agagacctga      476
 Leu Gln Tyr Ser Ser Tyr Ser Ser Ser Val 
  70                  75

 gacatgctgg accagtgttt tccaaagtac agctcacagg ctactaccaa gtgttggtca    536

 ataaaggtat tctgaggtca actaagattg atataaagtt aaactaatgt atttcagtat    596

 ctctcagagg cattcataat gctcgtgtgc actgtgaatc tcccaaaggg gagaaattgt    656

 gtgctgcagt ttcttgctta atttgaccac agaactcttt ttcatgagat taatattcct    716

 tggaacacat gtttggaaaa tgctaatggt ggtggaactg agctcatgag aggttaaata    776

 acttgtgcaa gaccacactg agatgcagca ctggtagaaa tccagccctg atgtatcctt    836

 tgactcaggt agacaagatc ttcaggtgca agcttaggag ccatctccct acagccatgg    896

 gcctcacaat gttggtggct ttacttttta tttttcaata atggccaact tgctatttaa    956

 ctgtgataaa gggaaatgtt tctgaagaca ttttaaagtt ttttatacat acgtaagatt   1016

 tttatataca tacgtaagga ttagatacta tgattacttt ttttgtattt tgaaattgaa   1076

 ggcacttaag ctcttgtgat attttgaatt gactgatcca tttaaaaaat tgtttagcta   1136

 taggtgtttg taacaatttc ttataaaatg attttttttc ttgattcatg atattaaact   1196

 ccagattgaa atgaggggct atgagctttg accctgagga aagaaggcca aaacatagat   1256

 ctgaggaaag atttgaacat ggcaagacaa tctcagggtt aagatgttgc taagttgatt   1316

 ctgagaatca aaatcaggct ttttttcctg tgatgggatc ataaaaataa tctttttatc   1376

 aggacaaagg ttatgggcaa ggatagacag attttggcac tga                     1419




      <210> 290
      <211> 1152
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (460)..(873)

      <400> 290
 cggaggagct cactaacagc agagagcaag ccggcgcgtg gcccggccgg ggtgcccaag     60

 acgctgggcc actgggaccc gagcgcgcga ccccagccgg aattcggagc taaggctgcc    120

 gcgctccggc aaaacgcgct tgatgaggtc gttaaagatt tccccctctg gaaaatcgcc    180

 agggaaaagt ggtgaaaaac gaagccggga gggccctagt ctcgggagtc taggaggagc    240

 ccaacccccg gacctaatgc cgcagggaga aaagacagag cagcgagcgc aaataccatc    300

 ctagctccaa taaaagggaa cgacttttac cgcaggaaga acctaggcct ggaagccacg    360

 cgagatctgg gggtcgggat cacgttgcgt tgcctagcga cagcagggac gctcgtggga    420

 ccccaggcta aaccccgctg tagccttaaa tctcctacc   atg gag gaa gaa ggc     474
                                              Met Glu Glu Glu Gly
                                                1               5

 ggc ggc cgc agc tgt ggg acc act agg gag ctg cag aag ctg aag cag      522
 Gly Gly Arg Ser Cys Gly Thr Thr Arg Glu Leu Gln Lys Leu Lys Gln
                  10                  15                  20

 cag gcg atg gag tac tac cgg gag aac gac gtt ccg cgc agg ctg gaa      570
 Gln Ala Met Glu Tyr Tyr Arg Glu Asn Asp Val Pro Arg Arg Leu Glu
              25                  30                  35

 gag ctg ctc aac tcc acc ttc tac ctc cag cct gcc gac gtc tac ggg      618
 Glu Leu Leu Asn Ser Thr Phe Tyr Leu Gln Pro Ala Asp Val Tyr Gly
          40                  45                  50

 cac ctg gta ggg acc tgg gac aag cgc tct cct ccc gcc aac ccc tct      666
 His Leu Val Gly Thr Trp Asp Lys Arg Ser Pro Pro Ala Asn Pro Ser
      55                  60                  65

 ccc ccc gcc ccg cgc tgc ggc aac gcc ttg cgc ctg cgc ctg cgc ctc      714
 Pro Pro Ala Pro Arg Cys Gly Asn Ala Leu Arg Leu Arg Leu Arg Leu
  70                  75                  80                  85

 aga atc tcg cat gcc agc cgc ccg ggc cct ggg cct gcg tgt gcg gag      762
 Arg Ile Ser His Ala Ser Arg Pro Gly Pro Gly Pro Ala Cys Ala Glu
                  90                  95                 100

 gag act tct gga ggg aag gag cgg gaa gga cac cca ggg gtg aag gga      810
 Glu Thr Ser Gly Gly Lys Glu Arg Glu Gly His Pro Gly Val Lys Gly
             105                 110                 115

 tct ccc cag aga aag tgg cag aaa gga ggc agc tgg agg aaa gag ggc      858
 Ser Pro Gln Arg Lys Trp Gln Lys Gly Gly Ser Trp Arg Lys Glu Gly
         120                 125                 130

 gct agg cgt att tga cctgcagcgg cagcccaggg gctggcaggc ttcctcgctg      913
 Ala Arg Arg Ile 
     135

 cctaagaggc ctctccgttt gtgggccggc ccaccgccca tgcttgccaa ttgtcatttt    973

 taacacatac cttaatgccc tcagctcagc tcaccgacct taagcagctc ctctttgatc   1033

 acaggatgaa cacccttgcg tttgctacaa cttggcttca gcctattctg gggcctcatc   1093

 ctactggctc ctctgccggg atgccagtaa tatctgacca gcccgcccta acttccaac    1152




      <210> 291
      <211> 344
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(252)

      <400> 291
 aggagggggc agggacggga cgtgggaaaa tgactacgcg tcactcgtga tgtcgcgcat     60

 ccgataggcc cttttcag  atg gca aaa ggc ctg agg gtg aat ctg ggc gag     111
                      Met Ala Lys Gly Leu Arg Val Asn Leu Gly Glu
                        1               5                  10

 ctg gtt gag tcc atg cgt ttg tgc ttc ctc tca gtc cac ttt cgc tta      159
 Leu Val Glu Ser Met Arg Leu Cys Phe Leu Ser Val His Phe Arg Leu
              15                  20                  25

 cga tgg ggc gac tct tgt cca tcg tca cct cac cgg gaa act ttt cct      207
 Arg Trp Gly Asp Ser Cys Pro Ser Ser Pro His Arg Glu Thr Phe Pro
          30                  35                  40

 gcc ggg cca gtt aat ggt ccc ctg tac cat ccc cat cct gag tga cta      255
 Ala Gly Pro Val Asn Gly Pro Leu Tyr His Pro His Pro Glu 
      45                  50                  55

 ctaagcagcc gcagcgactc ggggttgctc cgtgaccacg ttactcagtt aaccttcttg    315

 ttccctggag aggcggagct gaatggccc                                      344




      <210> 292
      <211> 589
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (35)..(268)

      <400> 292
 ggctgctggc agcgctggaa actgggtgga cggc    atg ggt tgg tct cag gat      52
                                          Met Gly Trp Ser Gln Asp
                                            1               5

 ttg ttc cgc gcc ttg tgg aga tcg ctg tca agg gaa gtg aag gag cac      100
 Leu Phe Arg Ala Leu Trp Arg Ser Leu Ser Arg Glu Val Lys Glu His
              10                  15                  20

 gtg ggc acg gac caa ttc ggg aac aaa tac tac tac atc ccg cag tac      148
 Val Gly Thr Asp Gln Phe Gly Asn Lys Tyr Tyr Tyr Ile Pro Gln Tyr
          25                  30                  35

 aag aac tgg aga gga caa act att cga gag aaa aga att gta gaa gca      196
 Lys Asn Trp Arg Gly Gln Thr Ile Arg Glu Lys Arg Ile Val Glu Ala
      40                  45                  50

 gca aat aaa aaa gaa gta gac tat gaa gca ggg gat att cca aca gaa      244
 Ala Asn Lys Lys Glu Val Asp Tyr Glu Ala Gly Asp Ile Pro Thr Glu
  55                  60                  65                  70

 tgg gaa gga aat act aaa gaa tga aaaacacaga gaagaaatca aaataaaaag     298
 Trp Glu Gly Asn Thr Lys Glu 
                  75

 ccaagatttt tatgaaaaag aaaaactcct tagtaaagag accagtgagg aactcctgcc    358

 tccaccagtt caaactcaaa ttaaaggcca tgcctctgct ccatactttg gaaaggaaga    418

 accctcagtg gctcccagca gcactggtaa aacctttcag ccaggatcct ggatgccacg    478

 agatggcaag agccacaatc aatgaatgca ttatggtcaa atcttttcat gtatatggat    538

 gtgactattt taacaaataa aagaagtgaa aagttaaaaa aaaaaaaaaa a             589




      <210> 293
      <211> 619
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(597)

      <400> 293
  atg gaa tcc tat ttt ttc aaa gag aca tcc cat gag tct gtg gat agc      48
  Met Glu Ser Tyr Phe Phe Lys Glu Thr Ser His Glu Ser Val Asp Ser
    1               5                  10                  15

 agc aaa gag gaa ccc cag acc ctt cca gag acc cag gat ggg gac ctc       96
 Ser Lys Glu Glu Pro Gln Thr Leu Pro Glu Thr Gln Asp Gly Asp Leu
              20                  25                  30

 cac ctg caa gaa caa ggc tca gga att gat tgg tgt ctt tcc cct gcc      144
 His Leu Gln Glu Gln Gly Ser Gly Ile Asp Trp Cys Leu Ser Pro Ala
          35                  40                  45

 gat gtg gaa gca cag acc aca aat gac caa aag ggt aat atc ccc gat      192
 Asp Val Glu Ala Gln Thr Thr Asn Asp Gln Lys Gly Asn Ile Pro Asp
      50                  55                  60

 gaa agc caa gtg gag aaa ctg aac gtt ttc ctt tct cct cct gat gtc      240
 Glu Ser Gln Val Glu Lys Leu Asn Val Phe Leu Ser Pro Pro Asp Val
  65                  70                  75                  80

 atc aac tat ctt gcc ctc aca gaa gcc aca gga cgg ata tgt gtg tct      288
 Ile Asn Tyr Leu Ala Leu Thr Glu Ala Thr Gly Arg Ile Cys Val Ser
                  85                  90                  95

 cag tgg gaa ggc ccc cca cgt ttg gga tgc ata ttt tgc cac gga gat      336
 Gln Trp Glu Gly Pro Pro Arg Leu Gly Cys Ile Phe Cys His Gly Asp
             100                 105                 110

 cat ctt ctg gca gtg aat gac ctg aaa ccc cag agc ctg gag gag gtc      384
 His Leu Leu Ala Val Asn Asp Leu Lys Pro Gln Ser Leu Glu Glu Val
         115                 120                 125

 tcc ctg ttt ctt acc cgg tcc atc cag aag gag aaa tta aag ctt acc      432
 Ser Leu Phe Leu Thr Arg Ser Ile Gln Lys Glu Lys Leu Lys Leu Thr
     130                 135                 140

 atc ggc agg atc cca aat tca gag aca ttc cat gcc gca tcc tgt atg      480
 Ile Gly Arg Ile Pro Asn Ser Glu Thr Phe His Ala Ala Ser Cys Met
 145                 150                 155                 160

 tgt ccc tca aaa tgc caa agt gct gca cct tct cag ctg gat aag cct      528
 Cys Pro Ser Lys Cys Gln Ser Ala Ala Pro Ser Gln Leu Asp Lys Pro
                 165                 170                 175

 aga ctg aac aga gct ccc aag agg agt ccg gcc att aaa aag agc cag      576
 Arg Leu Asn Arg Ala Pro Lys Arg Ser Pro Ala Ile Lys Lys Ser Gln
             180                 185                 190

 cag aaa gga gcc agg gag taa cgcaccccag acccatggca gc                 619
 Gln Lys Gly Ala Arg Glu 
         195





      <210> 294
      <211> 1954
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (428)..(1429)

      <400> 294
 cagggacaga gggtgaggct cagtgggaga gaaaggggag acagggtatg ggggtaacca     60

 ggaggcagag aaagtggaga agagcggagg gagttgaggg ggaggcagga accaaggtgt    120

 agccaagcgg caggtgaggg aggagggact ctgagcctgg gccaggggag tcagaaggcc    180

 ggagccctga agggccccac agccctcccc ggccctgctg tctccataca attctgtggc    240

 caaggagtga accttgcatg atttcagcca ccccacccag acacccccca ccctggaaca    300

 aaggggaagt ggccccatgg gcctgcctgc ttccagctca gggctgggct tggtcaccag    360

 gcaggcactt gttgtagcaa cagtccctgg ggacccatcc tggggaacag gactgctagc    420

 agtaaag  atg ggg gag cca ggg ccc cca tcc cct cca gcc ccc aag gct     469
          Met Gly Glu Pro Gly Pro Pro Ser Pro Pro Ala Pro Lys Ala
            1               5                  10

 gcc cca ggc ctc att gac agc ttc tct gag atg aac aac tac cgg cgg      517
 Ala Pro Gly Leu Ile Asp Ser Phe Ser Glu Met Asn Asn Tyr Arg Arg
  15                  20                  25                  30

 gcc atg cag aag atg gca gag gac atc ctg tct ctg cgg aga cag gcc      565
 Ala Met Gln Lys Met Ala Glu Asp Ile Leu Ser Leu Arg Arg Gln Ala
                  35                  40                  45

 agc atc ctg gaa gga gag aac cgc ata ctg agg agc cgc ctg gcc cag      613
 Ser Ile Leu Glu Gly Glu Asn Arg Ile Leu Arg Ser Arg Leu Ala Gln
              50                  55                  60

 cag gag gag gaa gag ggg cag ggc aaa gcc agt gag gcc cag aac acg      661
 Gln Glu Glu Glu Glu Gly Gln Gly Lys Ala Ser Glu Ala Gln Asn Thr
          65                  70                  75

 gtg tcc atg aag cag aaa ctg ctg ctg agt gag ctg gat atg aag aaa      709
 Val Ser Met Lys Gln Lys Leu Leu Leu Ser Glu Leu Asp Met Lys Lys
      80                  85                  90

 ctg agg gac agg gtg cag cat ttg cag aat gag ctg att cga aag aat      757
 Leu Arg Asp Arg Val Gln His Leu Gln Asn Glu Leu Ile Arg Lys Asn
  95                 100                 105                 110

 gat cga gag aag gag ctg ctc ctt ctg tat cag gcc cag cag cca cag      805
 Asp Arg Glu Lys Glu Leu Leu Leu Leu Tyr Gln Ala Gln Gln Pro Gln
                 115                 120                 125

 gcc gct ctg ctg aag cag tac cag ggc aag ctg cag aag atg aag gcg      853
 Ala Ala Leu Leu Lys Gln Tyr Gln Gly Lys Leu Gln Lys Met Lys Ala
             130                 135                 140

 ctg gag gag act gtg cgg cac caa gag aag gtg atc gag aag atg gag      901
 Leu Glu Glu Thr Val Arg His Gln Glu Lys Val Ile Glu Lys Met Glu
         145                 150                 155

 cgg gtg ctg gag gac agg ctg cag gac agg agc aag ccc cct cct ctg      949
 Arg Val Leu Glu Asp Arg Leu Gln Asp Arg Ser Lys Pro Pro Pro Leu
     160                 165                 170

 aac agg cag cag gga aag ccc tac acg ggc ttc cct atg ctc tca gcc      997
 Asn Arg Gln Gln Gly Lys Pro Tyr Thr Gly Phe Pro Met Leu Ser Ala
 175                 180                 185                 190

 tct ggc ctt ccc ttg ggt tct atg gga gag aac ctg ccg gtt gaa ctt     1045
 Ser Gly Leu Pro Leu Gly Ser Met Gly Glu Asn Leu Pro Val Glu Leu
                 195                 200                 205

 tac tcg gtg ctg ctg gca gaa aac gcg aag ctg cgg acg gag ctg gat     1093
 Tyr Ser Val Leu Leu Ala Glu Asn Ala Lys Leu Arg Thr Glu Leu Asp
             210                 215                 220

 aag aac cgc cac cag cag gcc ccc atc att ctg cag caa cag gcc ctg     1141
 Lys Asn Arg His Gln Gln Ala Pro Ile Ile Leu Gln Gln Gln Ala Leu
         225                 230                 235

 ccg gat ctc ctc tct ggt act tca gac aag ttc aac ctc ctg gcc aag     1189
 Pro Asp Leu Leu Ser Gly Thr Ser Asp Lys Phe Asn Leu Leu Ala Lys
     240                 245                 250

 ctg gaa cac gct cag agc cgg atc ctg tcc ctg gaa agc cag tta gag     1237
 Leu Glu His Ala Gln Ser Arg Ile Leu Ser Leu Glu Ser Gln Leu Glu
 255                 260                 265                 270

 gac tca gct cga cgc tgg gga cga gag aag cag gat ctg gcc aca cgg     1285
 Asp Ser Ala Arg Arg Trp Gly Arg Glu Lys Gln Asp Leu Ala Thr Arg
                 275                 280                 285

 ctg cag gag caa gaa aaa ggt ttc agg cac ccc tcg aac tcc atc atc     1333
 Leu Gln Glu Gln Glu Lys Gly Phe Arg His Pro Ser Asn Ser Ile Ile
             290                 295                 300

 ata gaa cag cct gtg agt gac ccc cct gga gta gct ccc agg ggt tca     1381
 Ile Glu Gln Pro Val Ser Asp Pro Pro Gly Val Ala Pro Arg Gly Ser
         305                 310                 315

 ggt ggt gga gca gga agc cac cgc acc ccc aaa gtc act ggg ccc tga     1429
 Gly Gly Gly Ala Gly Ser His Arg Thr Pro Lys Val Thr Gly Pro 
     320                 325                 330

 gaaaagccat tgtggagcca actccaggct gggggtcagg agtcctaggc tcccattcct   1489

 gctccattac caaccgaagg ctcggtctta attcccccac ctgtctaagg ggaacagaaa   1549

 acccctgcca aaactaccct ttcccccatg gggtgctatg aaactcaagg agatgactgt   1609

 ggatgagggg tccatgcagg catctccagg atgccctgac actgtgcttt aggactggct   1669

 gcgctcatgg gcagagtagc ttgtggccct acccccctga atccatagag cctaagattc   1729

 tcaaatttag cacacccttc tcagatggcc acgatgtagg ctccactttg caacttcccg   1789

 agaacaaaca ggctgtcaaa atggccctca agttcaaccc cgggacgcca gcccgaagaa   1849

 gaccttgatt tcctgtcttg agcaggtgtg tttggccgtg gcagaagctc agagcggtct   1909

 gggaaggctg gaagggtggg gacacgcagg aacaaggaac tttga                   1954




      <210> 295
      <211> 1286
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(873)

      <400> 295
  atg tgg atg cac gtg gcc aag gtg cac cct aag ggg gga gaa atg gtg      48
  Met Trp Met His Val Ala Lys Val His Pro Lys Gly Gly Glu Met Val
    1               5                  10                  15

 ggc gcc atc agg aac gcc gcc ttc ttg gca aag cct tca ata ccc cag       96
 Gly Ala Ile Arg Asn Ala Ala Phe Leu Ala Lys Pro Ser Ile Pro Gln
              20                  25                  30

 gtc cca aac tac agg ctg tcg atg acg atc cca gac tgg ctc cag gcg      144
 Val Pro Asn Tyr Arg Leu Ser Met Thr Ile Pro Asp Trp Leu Gln Ala
          35                  40                  45

 atc cag aat tac atg aag acc cta caa tat aat cac aca ggg acc cag      192
 Ile Gln Asn Tyr Met Lys Thr Leu Gln Tyr Asn His Thr Gly Thr Gln
      50                  55                  60

 ttc ttt gaa att agg aaa atg aga ccg ctg agt ggg tta atg gaa aca      240
 Phe Phe Glu Ile Arg Lys Met Arg Pro Leu Ser Gly Leu Met Glu Thr
  65                  70                  75                  80

 gca aaa gaa atg acc cga gag tcc ttg cct atc aaa tgc ctt gaa gct      288
 Ala Lys Glu Met Thr Arg Glu Ser Leu Pro Ile Lys Cys Leu Glu Ala
                  85                  90                  95

 gtc atc ctg ggc atc tac tta acc aat ggg cag cct tcc att gag cgg      336
 Val Ile Leu Gly Ile Tyr Leu Thr Asn Gly Gln Pro Ser Ile Glu Arg
             100                 105                 110

 ttc ccc atc agc ttt aaa acc tac ttc tca gga aac tac ttt cac cac      384
 Phe Pro Ile Ser Phe Lys Thr Tyr Phe Ser Gly Asn Tyr Phe His His
         115                 120                 125

 gtt gtg ctg ggg att tac tgc aat ggc cgc tat ggc tca ttg ggc atg      432
 Val Val Leu Gly Ile Tyr Cys Asn Gly Arg Tyr Gly Ser Leu Gly Met
     130                 135                 140

 agc cgc agg gct gag ctg atg gac aag cca ttg act ttt cgg act ctg      480
 Ser Arg Arg Ala Glu Leu Met Asp Lys Pro Leu Thr Phe Arg Thr Leu
 145                 150                 155                 160

 agt gac ctc atc ttt gac ttt gag gac tct tac aag aaa tac ctg cac      528
 Ser Asp Leu Ile Phe Asp Phe Glu Asp Ser Tyr Lys Lys Tyr Leu His
                 165                 170                 175

 aca gtc aag aag gtc aag att ggg ctg tac gtc ccc cat gag cct cat      576
 Thr Val Lys Lys Val Lys Ile Gly Leu Tyr Val Pro His Glu Pro His
             180                 185                 190

 agc ttc cag ccc att gag tgg aag cag ctg gtc ctc aac gtc tca aag      624
 Ser Phe Gln Pro Ile Glu Trp Lys Gln Leu Val Leu Asn Val Ser Lys
         195                 200                 205

 atg ctg agg gct gac ata agg aag gag ctg gag aaa tat gcc agg gac      672
 Met Leu Arg Ala Asp Ile Arg Lys Glu Leu Glu Lys Tyr Ala Arg Asp
     210                 215                 220

 atg aga atg aag atc ctg aaa cct gca agt gcc cac tct ccg acc caa      720
 Met Arg Met Lys Ile Leu Lys Pro Ala Ser Ala His Ser Pro Thr Gln
 225                 230                 235                 240

 gtg aga agc cgg gga aaa tcc ctg tcc ccc aga agg aga cag gca agc      768
 Val Arg Ser Arg Gly Lys Ser Leu Ser Pro Arg Arg Arg Gln Ala Ser
                 245                 250                 255

 ccc ccg agg agg ctc ggc cgg cga gag aag tcg cct gca ctg cct gaa      816
 Pro Pro Arg Arg Leu Gly Arg Arg Glu Lys Ser Pro Ala Leu Pro Glu
             260                 265                 270

 aag aag gtg gct gat ctg agc act ctg aat gaa gtg ggc tat caa atc      864
 Lys Lys Val Ala Asp Leu Ser Thr Leu Asn Glu Val Gly Tyr Gln Ile
         275                 280                 285

 cga att tag ccaagcc ataccggcca gcaagagggt ttctgtggtg cttctctctg      920
 Arg Ile 
     290

 cactttaccc agcatcttca ggaggaactg caactattta ttaagaactt gtgaatttta    980

 tttttaagga ttcacctgga aatagaatct gagtgggtgg taaccattag ctttaaaaaa   1040

 ttcactaaaa ggcaccatga aaaggctgaa gtaataagcc ccactggggt tggactatgt   1100

 ccctcaatca agatcttaag gataaccgta actcaacttt tacctttttc catttcccca   1160

 ttttctttca cttgctttcc acattatgcc tcaccaatag tcactgttca tccaacacaa   1220

 acaaaaaaac aaaaaaacat tggcggccgc cagctcttcc ccttagtagg gtaaatcctc   1280

 aaccct                                                              1286




      <210> 296
      <211> 1178
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (342)..(869)

      <400> 296
 tcgggatttt aactcgggcc ggctggctcc ggaatgcacc gtcttaacca tttttaggtt     60

 ctgctgcctc aaagacgtaa gaatagcaca ctctccttgt tgtaaggaag ggcttggttg    120

 gttttggagt ccaggttcta actcgccctg tgaccttggg caaggcattt tccctctctg    180

 gccgacgtta acttagctgt agaatgagga tgttggtgct ggggcagaac ccaacacttg    240

 actctattga taggtctggg gtgaggtcca agtgccgcat ttttaacaaa ctcagagaat    300

 ctttccacta taactcagct gaactcacat ctcccgtcaa c    atg tcc tac aac     353
                                                  Met Ser Tyr Asn
                                                    1

 tgc tgc tct gga aac ttc tcc tcc cgc tcc tgt ggt gac tac ctg cgc      401
 Cys Cys Ser Gly Asn Phe Ser Ser Arg Ser Cys Gly Asp Tyr Leu Arg
   5                  10                  15                  20

 tac cca gca tcc tca cgt ggc ttt tcc tac ccc agc aat ctg gtc tac      449
 Tyr Pro Ala Ser Ser Arg Gly Phe Ser Tyr Pro Ser Asn Leu Val Tyr
                  25                  30                  35

 agc act gac ctc tgc tct ccc agc acc tgc cag ctg ggt tcc tct ctc      497
 Ser Thr Asp Leu Cys Ser Pro Ser Thr Cys Gln Leu Gly Ser Ser Leu
              40                  45                  50

 tat agg ggc tgt cag gag atc tgc tgg gag ccc acc agc tgc cag acg      545
 Tyr Arg Gly Cys Gln Glu Ile Cys Trp Glu Pro Thr Ser Cys Gln Thr
          55                  60                  65

 tcc tat gtg gag tcc agc ccc tgc cag acc tcc tgc tac cgc ccc aga      593
 Ser Tyr Val Glu Ser Ser Pro Cys Gln Thr Ser Cys Tyr Arg Pro Arg
      70                  75                  80

 acc tcc ttg ctc tgc agt cct tgc aag acg act tac tct ggg tct cta      641
 Thr Ser Leu Leu Cys Ser Pro Cys Lys Thr Thr Tyr Ser Gly Ser Leu
  85                  90                  95                 100

 ggc ttt gga tcc agc agc tgc cgc tcc ctg ggc tat gga tcg agg agc      689
 Gly Phe Gly Ser Ser Ser Cys Arg Ser Leu Gly Tyr Gly Ser Arg Ser
                 105                 110                 115

 tgc tac tca gtg ggc tgt ggg tcc agt ggt gtc aga tcc ctg ggt tat      737
 Cys Tyr Ser Val Gly Cys Gly Ser Ser Gly Val Arg Ser Leu Gly Tyr
             120                 125                 130

 gga agc tgt ggc ttc cct tcc ctc ggc tat gga tct gga ttc tgc cgc      785
 Gly Ser Cys Gly Phe Pro Ser Leu Gly Tyr Gly Ser Gly Phe Cys Arg
         135                 140                 145

 cca acc tac ttg gct tct agg agc tgc cag tct cct tgt tac aga cca      833
 Pro Thr Tyr Leu Ala Ser Arg Ser Cys Gln Ser Pro Cys Tyr Arg Pro
     150                 155                 160

 gcc tat gga tca acc ttc tgc aga tca act tgc tga attt ccagaccttt      883
 Ala Tyr Gly Ser Thr Phe Cys Arg Ser Thr Cys 
 165                 170                 175

 taagcaaagt gtctcagtct ctacgtagag ctgttatcat aggcatttcc agcaatgtga    943

 gctaacccct cttactacta gctcttcatc ctttctctgg catcaagtac tggctggaca   1003

 ggctagttct ttcagactgt gaaattaatg aatgagcaaa atatagagtc aaatgtctat   1063

 aattttgaaa caagtgattc gttatcacgt aagttcatct tataaagtat atggaagttc   1123

 agttttgttt cacgtaataa attcatttac tgttgattcc aaaaaaaaaa aaaaa        1178




      <210> 297
      <211> 550
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (72)..(503)

      <400> 297
 gcaatttagc acccacatta ctgatgatta gacagaacta gcgtcttaag tctagtttcc     60

 ccatctgaac a atg tgg ata atg aca cgt acc tgg ggt ggg cag gct aga     110
              Met Trp Ile Met Thr Arg Thr Trp Gly Gly Gln Ala Arg
                1               5                  10

 gta aat ggg aaa atc aaa gcg cca gcc aga gcg ggt cgc act gtt agt      158
 Val Asn Gly Lys Ile Lys Ala Pro Ala Arg Ala Gly Arg Thr Val Ser
      15                  20                  25

 tcc tgt att ttc tcc tcc tgc ctc tgg ttt ctt ccg ttc cgt tct agc      206
 Ser Cys Ile Phe Ser Ser Cys Leu Trp Phe Leu Pro Phe Arg Ser Ser
  30                  35                  40                  45

 tgc ctg aag acc cag ccc gac agc gat gcc tgt cag ccc gcg tcg ccc      254
 Cys Leu Lys Thr Gln Pro Asp Ser Asp Ala Cys Gln Pro Ala Ser Pro
                  50                  55                  60

 acc agg gca gct gct ctc cca act cgc atg ggg ggc acc acc ccg cct      302
 Thr Arg Ala Ala Ala Leu Pro Thr Arg Met Gly Gly Thr Thr Pro Pro
              65                  70                  75

 cgg tgc cct aga gct gag cgc agc cgc ggc tcc acg ggg atc gcc agg      350
 Arg Cys Pro Arg Ala Glu Arg Ser Arg Gly Ser Thr Gly Ile Ala Arg
          80                  85                  90

 gcc tca gcc ctc gcg gcc ggc ggc gcg gga gtg ttg cgg ggc agg gac      398
 Ala Ser Ala Leu Ala Ala Gly Gly Ala Gly Val Leu Arg Gly Arg Asp
      95                 100                 105

 cag agc gcg atc aga gcg gcc acc ccc gat tta ggt cgc cag ctt tcc      446
 Gln Ser Ala Ile Arg Ala Ala Thr Pro Asp Leu Gly Arg Gln Leu Ser
 110                 115                 120                 125

 agt cac tgc gat ggc cac tgg ggc gcc cct tcc atc ctg gtt aaa ttc      494
 Ser His Cys Asp Gly His Trp Gly Ala Pro Ser Ile Leu Val Lys Phe
                 130                 135                 140

 tca ttg tga tccccag ccctcttcgt cggttcccca cacccaggag gccggttctc      550
 Ser Leu 






      <210> 298
      <211> 1493
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (161)..(1072)

      <400> 298
 aatttataat cttattaaag tgtttgtacc atgtcttatc tctttaaacc tactgtgctt     60

 tgacccttct ttctgcctct ctcctggtca ggctcctcct gctggaccct ccagccccgg    120

 gcctcaggag cccgagaagg aggagaggag ggtctggact  atg cct ccc atg gcc     175
                                              Met Pro Pro Met Ala
                                                1               5

 gtg gcc ctg aag cct gta ttg cag cag agc cgg gaa gca agg gac gag      223
 Val Ala Leu Lys Pro Val Leu Gln Gln Ser Arg Glu Ala Arg Asp Glu
                  10                  15                  20

 cta cct gga gcg cct cct gtt ctt tgc agt tcc tcc tca gat ctt agc      271
 Leu Pro Gly Ala Pro Pro Val Leu Cys Ser Ser Ser Ser Asp Leu Ser
              25                  30                  35

 ctc ctg ttg ggc ccc tct ttt cag agc cag cat tct ttc cag ccc ctg      319
 Leu Leu Leu Gly Pro Ser Phe Gln Ser Gln His Ser Phe Gln Pro Leu
          40                  45                  50

 gag ccc aaa cca gac ctc act tca tcc aca gct ggg gcc ttc tct gca      367
 Glu Pro Lys Pro Asp Leu Thr Ser Ser Thr Ala Gly Ala Phe Ser Ala
      55                  60                  65

 ctt ggg gcc ttc cat ccc gat cat agg gca gaa agg cca ttc cct gag      415
 Leu Gly Ala Phe His Pro Asp His Arg Ala Glu Arg Pro Phe Pro Glu
  70                  75                  80                  85

 gaa gat cct gga cct gac ggg gag ggc ctc cta aag caa ggg ctg ccg      463
 Glu Asp Pro Gly Pro Asp Gly Glu Gly Leu Leu Lys Gln Gly Leu Pro
                  90                  95                 100

 cct gct cag ctg gag ggc ctc aag aat ttt ttg cac cag ttg ctg gag      511
 Pro Ala Gln Leu Glu Gly Leu Lys Asn Phe Leu His Gln Leu Leu Glu
             105                 110                 115

 aca gtg ccc cag aac aat gag aac cct tct gtc gac ctg ttg ccc cct      559
 Thr Val Pro Gln Asn Asn Glu Asn Pro Ser Val Asp Leu Leu Pro Pro
         120                 125                 130

 aag tct ggt cct ctg act gtc cca tct tgg gag gaa gcc cct caa gtg      607
 Lys Ser Gly Pro Leu Thr Val Pro Ser Trp Glu Glu Ala Pro Gln Val
     135                 140                 145

 cca cgt att cca ccg cct gtc cac aaa acc aaa gtt ccc tta gcc atg      655
 Pro Arg Ile Pro Pro Pro Val His Lys Thr Lys Val Pro Leu Ala Met
 150                 155                 160                 165

 gca tcc agt ctt ttc cgg gtc cct gag cct ccc tcc tcc cat tca caa      703
 Ala Ser Ser Leu Phe Arg Val Pro Glu Pro Pro Ser Ser His Ser Gln
                 170                 175                 180

 ggc agt ggt ccc agc agt ggt tcc cca gag aga ggt gga gat ggg ctt      751
 Gly Ser Gly Pro Ser Ser Gly Ser Pro Glu Arg Gly Gly Asp Gly Leu
             185                 190                 195

 aca ttc cca agg cag ctg atg gag gtg tct caa ctg ttg cga ctc tac      799
 Thr Phe Pro Arg Gln Leu Met Glu Val Ser Gln Leu Leu Arg Leu Tyr
         200                 205                 210

 cag gct cgg ggc tgg ggg gct ctg cct gct gag gat ctc ctg ctc tac      847
 Gln Ala Arg Gly Trp Gly Ala Leu Pro Ala Glu Asp Leu Leu Leu Tyr
     215                 220                 225

 ctg aag agg ctg gaa cac agc ggc agg act gat ggc cga ggg gat aat      895
 Leu Lys Arg Leu Glu His Ser Gly Arg Thr Asp Gly Arg Gly Asp Asn
 230                 235                 240                 245

 gtc ccc aga agg aac aca gac tcc cgc ttg ggt gag atc ccc cgg aaa      943
 Val Pro Arg Arg Asn Thr Asp Ser Arg Leu Gly Glu Ile Pro Arg Lys
                 250                 255                 260

 gag att ccc tcc cag gct gtc cct cgc cgc ctt gct aca gcc ccc aag      991
 Glu Ile Pro Ser Gln Ala Val Pro Arg Arg Leu Ala Thr Ala Pro Lys
             265                 270                 275

 act gaa aaa cct ccc gca cgg aag aaa agt ggg cac cct gcc ccg agt     1039
 Thr Glu Lys Pro Pro Ala Arg Lys Lys Ser Gly His Pro Ala Pro Ser
         280                 285                 290

 agc atg agg agc cgg ggg gga gtc tgg aga tga gcccccct accctctctc     1090
 Ser Met Arg Ser Arg Gly Gly Val Trp Arg 
     295                 300

 ctctttgttc tctcattgtt gttattttaa taaatgctca ttagtctgta tcagagtctc   1150

 tggctcatag gaatttggaa aatagaggtt ttgtagggaa tcacttcgta aagaaaccac   1210

 atttggttga gtactttttt tatatgttac atgtttatat gtcatttcct gtgggaaaag   1270

 acatgaatgc tttggaagac ggtctatgac aagatttgga aagttggggc ggctaagatt   1330

 cagtggacaa agctaaaacc tgcagagcaa tgaactctgg gtggtagtgg aattatgggt   1390

 gattcttagt tttttaatac gtttctgtat tttccaaatt ttctaaaaca agtatatgtt   1450

 actttaataa tcagaaaaga cccaaacttt aaaaaaaaaa aaa                     1493




      <210> 299
      <211> 1554
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (295)..(1179)

      <400> 299
 tgctcaatac ggaacatatt ctcagtcctc ctctggtcta caaagcctgt gatttcttgt     60

 ctatggacag aacgtctggt ttaatctaca ggaacccata acttcctgaa gctttatgct    120

 taacagtgac aacgtgagtc agttgaattt tattgtgttt cagtccgtag agtattagct    180

 acagaaacct ttccattgcc atactgagaa actgcagcag gcagtgtgcc tacaggtcta    240

 caaagaaact tcagatcatc ttcttgaggg aaagaagctg aagtgctaca taag  atg     297
                                                              Met
                                                                1

 ctt gtg ctt cat aac tct cag aag ctg cag att ctg tat aaa tcc tta      345
 Leu Val Leu His Asn Ser Gln Lys Leu Gln Ile Leu Tyr Lys Ser Leu
               5                  10                  15

 gaa aag agc atc cct gaa tcc ata aag gta tat ggc gcc att ttc aac      393
 Glu Lys Ser Ile Pro Glu Ser Ile Lys Val Tyr Gly Ala Ile Phe Asn
          20                  25                  30

 ata aaa gat aaa aac cct ttc aac atg gag gtg ctg gta gat gcc tgg      441
 Ile Lys Asp Lys Asn Pro Phe Asn Met Glu Val Leu Val Asp Ala Trp
      35                  40                  45

 cca gat tac cag atc gtc att acc cgg cct cag aaa cag gag atg aaa      489
 Pro Asp Tyr Gln Ile Val Ile Thr Arg Pro Gln Lys Gln Glu Met Lys
  50                  55                  60                  65

 gat gac cag gat cat tat acc aac act tac cac atc ttc acc aaa gct      537
 Asp Asp Gln Asp His Tyr Thr Asn Thr Tyr His Ile Phe Thr Lys Ala
                  70                  75                  80

 cct gac aaa tta gag gaa gtc ctg tca tac tcc aat gta atc agc tgg      585
 Pro Asp Lys Leu Glu Glu Val Leu Ser Tyr Ser Asn Val Ile Ser Trp
              85                  90                  95

 gag caa act ttg cag atc caa ggt tgc caa gag ggc ttg gat gaa gca      633
 Glu Gln Thr Leu Gln Ile Gln Gly Cys Gln Glu Gly Leu Asp Glu Ala
         100                 105                 110

 ata aga aag gtt gca act tca aaa tca gtg cag gta gat tac atg aaa      681
 Ile Arg Lys Val Ala Thr Ser Lys Ser Val Gln Val Asp Tyr Met Lys
     115                 120                 125

 acc atc ctc ttt ata ccg gaa tta cca aag aaa cac aag acc tca agt      729
 Thr Ile Leu Phe Ile Pro Glu Leu Pro Lys Lys His Lys Thr Ser Ser
 130                 135                 140                 145

 aat gac aag atg gag tta ttt gaa gtg gat gat gat aac aag gaa gga      777
 Asn Asp Lys Met Glu Leu Phe Glu Val Asp Asp Asp Asn Lys Glu Gly
                 150                 155                 160

 aac ttt tca aac atg ttc tta gat gct tca cat gca ggt ctt gtg aat      825
 Asn Phe Ser Asn Met Phe Leu Asp Ala Ser His Ala Gly Leu Val Asn
             165                 170                 175

 gaa cac tgg gcc ttt ggg aaa aat gag agg agc ttg aaa tat att gaa      873
 Glu His Trp Ala Phe Gly Lys Asn Glu Arg Ser Leu Lys Tyr Ile Glu
         180                 185                 190

 cgc tgc ctc cag gat ttt cta gga ttt ggt gtg ctg ggt cca gag ggc      921
 Arg Cys Leu Gln Asp Phe Leu Gly Phe Gly Val Leu Gly Pro Glu Gly
     195                 200                 205

 cag ctt gtc tct tgg att gtg atg gaa cag tcc tgt gag ttg aga atg      969
 Gln Leu Val Ser Trp Ile Val Met Glu Gln Ser Cys Glu Leu Arg Met
 210                 215                 220                 225

 ggt tat act gtc ccc aaa tac aga cac caa ggc aac atg ttg caa att     1017
 Gly Tyr Thr Val Pro Lys Tyr Arg His Gln Gly Asn Met Leu Gln Ile
                 230                 235                 240

 ggt tat cat ctt gaa aag tat ctt tct cag aaa gaa atc cca ttt tat     1065
 Gly Tyr His Leu Glu Lys Tyr Leu Ser Gln Lys Glu Ile Pro Phe Tyr
             245                 250                 255

 ttc cat gtg gca gat aat aat gag aaa agc cta cag gca ctg aac aat     1113
 Phe His Val Ala Asp Asn Asn Glu Lys Ser Leu Gln Ala Leu Asn Asn
         260                 265                 270

 ttg ggg ttt aag att tgt cct tgt ggc tgg cat cag tgg aaa tgc acc     1161
 Leu Gly Phe Lys Ile Cys Pro Cys Gly Trp His Gln Trp Lys Cys Thr
     275                 280                 285

 ccc aag aaa tat tgt tga ttgatt ccactgtcca tttcaaatct ttcttatcag     1215
 Pro Lys Lys Tyr Cys 
 290

 taaaaaaaca ttaattcaaa cacaagcatt gtgatctaca ttagcacaaa atgcaactga   1275

 ttatctagga tctgtgtatt acttaagctc acccttaaca gttttacctt ccttctcctc   1335

 tgtattctta cagaaaatta gaagctcaat tttatggtct cataatttcc tttatgacag   1395

 acatctcaga attaaaatca cccaaagcca atcattagtg ccaagataac cctttaacgg   1455

 caacactttc ttaaatgaag actatttctt tcatgaaaaa attcactttt atgactttct   1515

 tgttaaaata aaaagtctgc ttttaaaaaa aaaaaaaaa                          1554




      <210> 300
      <211> 919
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (50)..(559)

      <400> 300
 taggacagct cctcttttgc cagagctagg caggcgccga agtagccgc    atg gcc      55
                                                          Met Ala
                                                            1

 ccg tca gaa gac ccc agg gac tgg aga gcc aac ctc aaa ggc acc atc      103
 Pro Ser Glu Asp Pro Arg Asp Trp Arg Ala Asn Leu Lys Gly Thr Ile
           5                  10                  15

 cgt gag aca ggc ctg gag acc agc tcc ggt ggg aag ctg gct ggc cat      151
 Arg Glu Thr Gly Leu Glu Thr Ser Ser Gly Gly Lys Leu Ala Gly His
      20                  25                  30

 cag aag acc gtc ccc acg gct cac ctg act ttt gtt att gac tgc acc      199
 Gln Lys Thr Val Pro Thr Ala His Leu Thr Phe Val Ile Asp Cys Thr
  35                  40                  45                  50

 cac ggg aag cag ctc tcc ctg gca gca acc gca tca cca ccc caa gcc      247
 His Gly Lys Gln Leu Ser Leu Ala Ala Thr Ala Ser Pro Pro Gln Ala
                  55                  60                  65

 ccc agt ccc aat cga ggg ctt gtc acc cca cca atg aag acc tac atc      295
 Pro Ser Pro Asn Arg Gly Leu Val Thr Pro Pro Met Lys Thr Tyr Ile
              70                  75                  80

 gtg ttc tgt ggg gaa aac tgg ccc cat ctg act cgg gtg acc ccc atg      343
 Val Phe Cys Gly Glu Asn Trp Pro His Leu Thr Arg Val Thr Pro Met
          85                  90                  95

 ggt ggg gga tgc ctt gcc cag gcc agg gcc acc ctg ccg ctc tgc aga      391
 Gly Gly Gly Cys Leu Ala Gln Ala Arg Ala Thr Leu Pro Leu Cys Arg
     100                 105                 110

 ggg tct gtg gcc tca gct tcc ttc cca gtc agc ccg ctc tgc ccc cag      439
 Gly Ser Val Ala Ser Ala Ser Phe Pro Val Ser Pro Leu Cys Pro Gln
 115                 120                 125                 130

 gag gtt ccc gag gct aag ggg aaa ccc gtg aag gct gcg cct gtg agg      487
 Glu Val Pro Glu Ala Lys Gly Lys Pro Val Lys Ala Ala Pro Val Arg
                 135                 140                 145

 tct tca act tgg gga aca gtc aag gac tca ctg aaa gcc ctc tcc tct      535
 Ser Ser Thr Trp Gly Thr Val Lys Asp Ser Leu Lys Ala Leu Ser Ser
             150                 155                 160

 tgt gtc tgt ggg cag gcc gat tag ctggaagggc cgggctctga tgcccagagg     589
 Cys Val Cys Gly Gln Ala Asp 
         165

 ctgcaattcc cagggcctgg ccctgcttcc ccagctaagc aggagtcttt tgtgcttgag    649

 ccaaggaaac atcattagat ccgctaaggg gcatctgaaa catccgtcga gtggcagagg    709

 caggataagt cacctgcaca tgaagagact cattcattca tacagcaaat attactggta    769

 catcttccac atgccaggcc ctgcaaagtg ctggggagat accatggttt tcctggagct    829

 ggtatttttg gggtggaggg aacccaccct gaataaataa agtaacccaa taaataaaga    889

 agatgatttt gaacagcgaa aaaaaaaaaa                                     919




      <210> 301
      <211> 915
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (452)..(901)

      <400> 301
 tcacgtcttt actcatagca tcttggaagc cagagcgaga ggctcctggg ttcacagact     60

 cgtaggaaat aagagggaag gacttcccca aggtcacacg gccagcgcgt ctgtggcaga    120

 gaggagtgtg cggatgggtt ggagagctgt ggggattgcc tggtcccccg tcagagtcct    180

 cttccttggc tcatgtccaa gtgtcccagc cccaggtagc gggacaggaa aggggcgtgg    240

 ctggcccccc gcttagaccc aggaaggcgg gagggacccc ttgggcactg gagctcctgg    300

 gtggccctgc agccggcact cccccgtctt ccagatgaca atttgtcggg cacgagcggt    360

 atggaagtgg acgaccgcga tgtacggcgc tggagcagcg gctgcagtta caggaagact    420

 gagctggcgg tcctaaaggc ggcgctggcg g   atg ctc tgc gct cgc cct ctt     472
                                      Met Leu Cys Ala Arg Pro Leu
                                        1               5

 ctg tcc cct aac ccc atc cct cca gtg tgt cag ctc ttg aaa ggc ctt      520
 Leu Ser Pro Asn Pro Ile Pro Pro Val Cys Gln Leu Leu Lys Gly Leu
          10                  15                  20

 ccc acc aga cgc ccc tta atg gct cgg gac ccc cgc ggc gcg tgg gtg      568
 Pro Thr Arg Arg Pro Leu Met Ala Arg Asp Pro Arg Gly Ala Trp Val
      25                  30                  35

 gct atg cca cgt ccc cat cct ctc cca aga agg agg cga cct ccg ggc      616
 Ala Met Pro Arg Pro His Pro Leu Pro Arg Arg Arg Arg Pro Pro Gly
  40                  45                  50                  55

 gca ggt aag gca caa ggc cgg gac ccc cag cct ctt cca aga cct cgt      664
 Ala Gly Lys Ala Gln Gly Arg Asp Pro Gln Pro Leu Pro Arg Pro Arg
                  60                  65                  70

 ggg aga cag agg tgg ttt gtt tgc ctg agc tcc agc agc aga ggg tgc      712
 Gly Arg Gln Arg Trp Phe Val Cys Leu Ser Ser Ser Ser Arg Gly Cys
              75                  80                  85

 agg gag aat ctc gct tgc tca cgg cac tcg cct gct ggc cta gaa ggc      760
 Arg Glu Asn Leu Ala Cys Ser Arg His Ser Pro Ala Gly Leu Glu Gly
          90                  95                 100

 tct gcc ccc acc tgt gtg ctc tct ttt agc agt gtc cgc cgc tac ttg      808
 Ser Ala Pro Thr Cys Val Leu Ser Phe Ser Ser Val Arg Arg Tyr Leu
     105                 110                 115

 tca cca gag cgc ctc gcc tcg gtg cgc cgt gag gac ccc cgc agc cgg      856
 Ser Pro Glu Arg Leu Ala Ser Val Arg Arg Glu Asp Pro Arg Ser Arg
 120                 125                 130                 135

 acc aca tcc tcc agc agc aac tgt agc gcc aaa aag gaa ggg taa gga      904
 Thr Thr Ser Ser Ser Ser Asn Cys Ser Ala Lys Lys Glu Gly 
                 140                 145

 ctggggcggc g                                                         915




      <210> 302
      <211> 1037
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (121)..(1005)

      <400> 302
 gcgacccggc ccagtgcgca gggggtgaaa gttgaactaa taaagtttgt acgagttcag     60

 tggaggagac cgcaagttga gtggaggagg cggcggtggg gccccggacc aggtgcctcc    120
                                                                 
 atg gca ggc tct gaa gag ctg ggg ctc cgg gaa gac acg ctg agg gtc      168
 Met Ala Gly Ser Glu Glu Leu Gly Leu Arg Glu Asp Thr Leu Arg Val
   1               5                  10                  15

 cta gct gcc ttc ctt agg cgt ggt gag gct gcc ggg tct cct gtt cca      216
 Leu Ala Ala Phe Leu Arg Arg Gly Glu Ala Ala Gly Ser Pro Val Pro
              20                  25                  30

 act cca cct aga agc cct gcc caa gaa gag cca aca gac ttc ctg agc      264
 Thr Pro Pro Arg Ser Pro Ala Gln Glu Glu Pro Thr Asp Phe Leu Ser
          35                  40                  45

 cgc ctt cga aga tgt ctt ccc tgc tcc ctg ggg cga gga gca gcc ccc      312
 Arg Leu Arg Arg Cys Leu Pro Cys Ser Leu Gly Arg Gly Ala Ala Pro
      50                  55                  60

 tct gag tcc cct cgg cct tgc tct ctg ccc atc cgc ccc tgc tat ggt      360
 Ser Glu Ser Pro Arg Pro Cys Ser Leu Pro Ile Arg Pro Cys Tyr Gly
  65                  70                  75                  80

 tta gag cct ggc cca gct act cca gac ttc tat gct ttg gtg gcc cag      408
 Leu Glu Pro Gly Pro Ala Thr Pro Asp Phe Tyr Ala Leu Val Ala Gln
                  85                  90                  95

 cgg ctg gaa cag ctg gtc caa gag cag ctg aaa tct ccg ccc agc cca      456
 Arg Leu Glu Gln Leu Val Gln Glu Gln Leu Lys Ser Pro Pro Ser Pro
             100                 105                 110

 gaa tta cag ggt ccc cca tcg aca gag aag gaa gcc ata ctg cgg agg      504
 Glu Leu Gln Gly Pro Pro Ser Thr Glu Lys Glu Ala Ile Leu Arg Arg
         115                 120                 125

 ctg gtg gcc ctg ctg gag gag gag gca gaa gtc att aac cag aag ctg      552
 Leu Val Ala Leu Leu Glu Glu Glu Ala Glu Val Ile Asn Gln Lys Leu
     130                 135                 140

 gcc tcg gac ccc gcc ctg cgc agc aag ctg gtc cgc ctg tcc tcc gac      600
 Ala Ser Asp Pro Ala Leu Arg Ser Lys Leu Val Arg Leu Ser Ser Asp
 145                 150                 155                 160

 tct ttc gcc cgc ctg gtg gag ctg ttc tgt agc cgg gat gac agc tct      648
 Ser Phe Ala Arg Leu Val Glu Leu Phe Cys Ser Arg Asp Asp Ser Ser
                 165                 170                 175

 cgc cca agc cga gca tgc ccc ggg ccc ccg cct cct tcc ccg gag ccc      696
 Arg Pro Ser Arg Ala Cys Pro Gly Pro Pro Pro Pro Ser Pro Glu Pro
             180                 185                 190

 ctg gcc cgc ctg gcc cta gcc atg gag ctg agc cgg cgc gtg gcc ggg      744
 Leu Ala Arg Leu Ala Leu Ala Met Glu Leu Ser Arg Arg Val Ala Gly
         195                 200                 205

 ctg ggg ggc acc ctg gcg gga ctc agc gtg gag cac gtg cac agc ttc      792
 Leu Gly Gly Thr Leu Ala Gly Leu Ser Val Glu His Val His Ser Phe
     210                 215                 220

 acg ccc ctg gat cca ggc cca cgg ggg ctg gga ggg cat cct ggt tgt      840
 Thr Pro Leu Asp Pro Gly Pro Arg Gly Leu Gly Gly His Pro Gly Cys
 225                 230                 235                 240

 ttc acc cgt gga ctt gaa ctt ggc act ggc gct gag cgc tct tct cac      888
 Phe Thr Arg Gly Leu Glu Leu Gly Thr Gly Ala Glu Arg Ser Ser His
                 245                 250                 255

 aaa gct ggt aca ccg att gac ctt cat gtc ctg gcc tct tcc ggt ggt      936
 Lys Ala Gly Thr Pro Ile Asp Leu His Val Leu Ala Ser Ser Gly Gly
             260                 265                 270

 tat caa gtt gta cta tac act cag ggt ggg ggt ggg ggt agg cta acg      984
 Tyr Gln Val Val Leu Tyr Thr Gln Gly Gly Gly Gly Gly Arg Leu Thr
         275                 280                 285

 gtt tgc caa agt att ggt taa ac ttttataaaa cgttaagtga aaaaaaaaaa     1037
 Val Cys Gln Ser Ile Gly 
     290





      <210> 303
      <211> 410
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(349)

      <400> 303
 cttcctgttt ttatgcccca aaagttgcct tttggcccgc catgcctcct gtcctgcacc     60

 catataagcc   atg aat ccc agg ctc cag gga cag acc agc aag cca gca     109
              Met Asn Pro Arg Leu Gln Gly Gln Thr Ser Lys Pro Ala
                1               5                  10

 gac cag atg atg gat ggt gga aca acg tgg cag aga aaa aga gaa gag      157
 Asp Gln Met Met Asp Gly Gly Thr Thr Trp Gln Arg Lys Arg Glu Glu
      15                  20                  25

 gag gaa cat ctg aat gcc aag aga agt ttg gct ggg ggc agt cag aaa      205
 Glu Glu His Leu Asn Ala Lys Arg Ser Leu Ala Gly Gly Ser Gln Lys
  30                  35                  40                  45

 gga gtc cag ctg ctg ggt ggc cca act cca gag gaa gat cac ctt ccc      253
 Gly Val Gln Leu Leu Gly Gly Pro Thr Pro Glu Glu Asp His Leu Pro
                  50                  55                  60

 att cca tcc cct tct tcc agg tcc cca tcc atc tca ctg cca cct cca      301
 Ile Pro Ser Pro Ser Ser Arg Ser Pro Ser Ile Ser Leu Pro Pro Pro
              65                  70                  75

 cca ctc aat aaa atc ttg cat tta tcc tca agc ttg cgt gtg acc tga      349
 Pro Leu Asn Lys Ile Leu His Leu Ser Ser Ser Leu Arg Val Thr 
          80                  85                  90

 ttcttccagg acactgggca agagcatagg aataaagaag gctgtcacac tggccctctg    409

 c                                                                    410




      <210> 304
      <211> 691
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (164)..(691)

      <400> 304
 tttcgtgcta cctggagatc cctctacttg ttgatgggca gcttcccggg ccactcctct     60

 caggaagttc ttctaaatca ggaatggatt gaaatctaat gaaccgaaac tttgggtaat    120

 tgatcaccct agacccaggg acacccaatt catcgtaatc atc  atg aat aat caa     175
                                                  Met Asn Asn Gln
                                                    1

 aaa gtg gta gct gtg cta ctg caa gag tgc aag caa gtg ctg gat cag      223
 Lys Val Val Ala Val Leu Leu Gln Glu Cys Lys Gln Val Leu Asp Gln
   5                  10                  15                  20

 ctc ttg ttg gaa gcg cca gat gtg tcg gaa gag gac aag agc gag gac      271
 Leu Leu Leu Glu Ala Pro Asp Val Ser Glu Glu Asp Lys Ser Glu Asp
                  25                  30                  35

 cag cgc tgc aga gct tta ctc ccc agc gag tta agg acc ctg atc cag      319
 Gln Arg Cys Arg Ala Leu Leu Pro Ser Glu Leu Arg Thr Leu Ile Gln
              40                  45                  50

 gag gca aag gaa atg aag tgg ccc ttc gtg cct gaa aag tgg cag tac      367
 Glu Ala Lys Glu Met Lys Trp Pro Phe Val Pro Glu Lys Trp Gln Tyr
          55                  60                  65

 aaa caa gcc gtg ggc cca gag gac aaa aca aac ctg aag gat gtg att      415
 Lys Gln Ala Val Gly Pro Glu Asp Lys Thr Asn Leu Lys Asp Val Ile
      70                  75                  80

 ggc gcc ggg ttg cag cag tta ctg gta gga aga gcc aca cca cct gtt      463
 Gly Ala Gly Leu Gln Gln Leu Leu Val Gly Arg Ala Thr Pro Pro Val
  85                  90                  95                 100

 cct ctg ata tcc cca agt ttg ggg gtc ctg atg ctg gag gga gac tgg      511
 Pro Leu Ile Ser Pro Ser Leu Gly Val Leu Met Leu Glu Gly Asp Trp
                 105                 110                 115

 ctt att tct gtg gag gga ggg gcc tgc tgt cag tca gcc ctg gat tta      559
 Leu Ile Ser Val Glu Gly Gly Ala Cys Cys Gln Ser Ala Leu Asp Leu
             120                 125                 130

 ctg tgg tgc cca ctc acg gag ata caa gat cat ttt tat agg ttg gca      607
 Leu Trp Cys Pro Leu Thr Glu Ile Gln Asp His Phe Tyr Arg Leu Ala
         135                 140                 145

 cta aaa gca cag tct gag gac atg aag cag gct cag aag gag gat att      655
 Leu Lys Ala Gln Ser Glu Asp Met Lys Gln Ala Gln Lys Glu Asp Ile
     150                 155                 160

 ctt ttt ccc atg tcc ttt tca act cta caa cca tga                      691
 Leu Phe Pro Met Ser Phe Ser Thr Leu Gln Pro 
 165                 170                 175





      <210> 305
      <211> 2145
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (335)..(1924)

      <400> 305
 caggaaactt cagtgtgact ctcaggcacc taacaatcac ttacttgctt tagatcactc     60

 aaatagagat ctcagcagca tatatacttc tgacagcact tctgattttt tcaagtcctg    120

 cagcaaggat actttttcaa aattctggca gccatcactt gaattcactt gcattgtttc    180

 acaactaaca gataatgatg atttttcagc ttcagaacaa agtaaggcct ttggtactct    240

 tcagcagaac agaaagtcca tctccattgc agaggccact ggttccagta gctgccatga    300

 tcccattcag gattcatgga gccttgtttc atat    atg gat aaa aag agt aca     352
                                          Met Asp Lys Lys Ser Thr
                                            1               5

 gca gaa aag ttg ggt aaa gaa ctt ggc tta caa gct aag gag ctg agt      400
 Ala Glu Lys Leu Gly Lys Glu Leu Gly Leu Gln Ala Lys Glu Leu Ser
              10                  15                  20

 gca gtt cac agc agt cat cat gaa att gga gtt aat gac tct aat tta      448
 Ala Val His Ser Ser His His Glu Ile Gly Val Asn Asp Ser Asn Leu
          25                  30                  35

 ttc tct ttg gaa atg cga gag ccc ctt gag tca agt aat aca aaa tcc      496
 Phe Ser Leu Glu Met Arg Glu Pro Leu Glu Ser Ser Asn Thr Lys Ser
      40                  45                  50

 ttc cac agt gca gtg gaa att aaa aat agg tcc cag cat gag cta cca      544
 Phe His Ser Ala Val Glu Ile Lys Asn Arg Ser Gln His Glu Leu Pro
  55                  60                  65                  70

 tgt ttt cag cat cat ggt ata gat acc cca act agc ctt cag aag aga      592
 Cys Phe Gln His His Gly Ile Asp Thr Pro Thr Ser Leu Gln Lys Arg
                  75                  80                  85

 tct gca tgt tgt cca cct tcg tta ctc aga ctt gaa gag aca gcc agc      640
 Ser Ala Cys Cys Pro Pro Ser Leu Leu Arg Leu Glu Glu Thr Ala Ser
              90                  95                 100

 agt tcc cag gat ggt gac cct caa att tgg gat gat ctg cca ttc tct      688
 Ser Ser Gln Asp Gly Asp Pro Gln Ile Trp Asp Asp Leu Pro Phe Ser
         105                 110                 115

 gaa agc ctg aac aag ttt ctg gca gtt ctt gaa agt gag att gct gta      736
 Glu Ser Leu Asn Lys Phe Leu Ala Val Leu Glu Ser Glu Ile Ala Val
     120                 125                 130

 acc cag gca gat gtc agt agt agg aaa cat cat gta gat aat gac att      784
 Thr Gln Ala Asp Val Ser Ser Arg Lys His His Val Asp Asn Asp Ile
 135                 140                 145                 150

 gat aaa ttt cat gca gac cac agc agt tta tct gtg act ccc cag aga      832
 Asp Lys Phe His Ala Asp His Ser Ser Leu Ser Val Thr Pro Gln Arg
                 155                 160                 165

 act act gga gcc ctg cat aca cca cct ata gct tta aga tca tca caa      880
 Thr Thr Gly Ala Leu His Thr Pro Pro Ile Ala Leu Arg Ser Ser Gln
             170                 175                 180

 gta ata gtc aaa gca aac tgt agc aaa gat gac ttc ctt ttc aac tgt      928
 Val Ile Val Lys Ala Asn Cys Ser Lys Asp Asp Phe Leu Phe Asn Cys
         185                 190                 195

 aaa gga aat cta agt cct agt gtt gaa aag gag tca caa cca gat aac      976
 Lys Gly Asn Leu Ser Pro Ser Val Glu Lys Glu Ser Gln Pro Asp Asn
     200                 205                 210

 aaa gta gag gct gtc tct gta aat cat aat gga aga gat atg tca gaa     1024
 Lys Val Glu Ala Val Ser Val Asn His Asn Gly Arg Asp Met Ser Glu
 215                 220                 225                 230

 tat ttt tta ccg aat cct tat ctg tca gct ctg tct tca tct tca aaa     1072
 Tyr Phe Leu Pro Asn Pro Tyr Leu Ser Ala Leu Ser Ser Ser Ser Lys
                 235                 240                 245

 gat tta gaa aca ata gtt act ctt aag aag act atc aga atc tca cca     1120
 Asp Leu Glu Thr Ile Val Thr Leu Lys Lys Thr Ile Arg Ile Ser Pro
             250                 255                 260

 cac agg gag agt gac cat tct agt cta aat aac aaa tat ttg aat gga     1168
 His Arg Glu Ser Asp His Ser Ser Leu Asn Asn Lys Tyr Leu Asn Gly
         265                 270                 275

 tgt gga gaa ata tca gtt tca gaa atg aat gaa aag ttg aca act ctg     1216
 Cys Gly Glu Ile Ser Val Ser Glu Met Asn Glu Lys Leu Thr Thr Leu
     280                 285                 290

 tgt tat agg aag tat aat gat gtc tct gat ctt tgc aaa tta gaa aat     1264
 Cys Tyr Arg Lys Tyr Asn Asp Val Ser Asp Leu Cys Lys Leu Glu Asn
 295                 300                 305                 310

 aaa caa tat tgt agg tgg tcc aag aac caa gat gac agt ttt aca att     1312
 Lys Gln Tyr Cys Arg Trp Ser Lys Asn Gln Asp Asp Ser Phe Thr Ile
                 315                 320                 325

 tgc agg aaa ctt aca tat cct tta gaa act ctt tgc aat agt cca aat     1360
 Cys Arg Lys Leu Thr Tyr Pro Leu Glu Thr Leu Cys Asn Ser Pro Asn
             330                 335                 340

 aga agt aca aat aca ttg aaa gaa atg cct tgg gga cat atc aat aac     1408
 Arg Ser Thr Asn Thr Leu Lys Glu Met Pro Trp Gly His Ile Asn Asn
         345                 350                 355

 aac gta aca cag agc tat tct att ggt tat gaa ggt agc tat gat gcc     1456
 Asn Val Thr Gln Ser Tyr Ser Ile Gly Tyr Glu Gly Ser Tyr Asp Ala
     360                 365                 370

 tct gct gat ctc ttt gat gat att gct aaa gaa atg gac att gca act     1504
 Ser Ala Asp Leu Phe Asp Asp Ile Ala Lys Glu Met Asp Ile Ala Thr
 375                 380                 385                 390

 gag att acc aaa aaa tca cag gat att ttg tta aaa tgg gga aca tct     1552
 Glu Ile Thr Lys Lys Ser Gln Asp Ile Leu Leu Lys Trp Gly Thr Ser
                 395                 400                 405

 ttg gca gaa agt cac cct tca gag tct gat ttt tca ctg aga tca ctt     1600
 Leu Ala Glu Ser His Pro Ser Glu Ser Asp Phe Ser Leu Arg Ser Leu
             410                 415                 420

 tct gaa gac ttc atc cag cct tca caa aaa tta tcc ttg caa agc cta     1648
 Ser Glu Asp Phe Ile Gln Pro Ser Gln Lys Leu Ser Leu Gln Ser Leu
         425                 430                 435

 tct gac tct agg cat tca aga aca tgc tct cca aca cct cat ttt caa     1696
 Ser Asp Ser Arg His Ser Arg Thr Cys Ser Pro Thr Pro His Phe Gln
     440                 445                 450

 tca gat tca gaa tat aat ttt gaa aat agt caa gac ttt gtt cca tgt     1744
 Ser Asp Ser Glu Tyr Asn Phe Glu Asn Ser Gln Asp Phe Val Pro Cys
 455                 460                 465                 470

 tca cag tca act cca att tca ggg ttc cac caa aca aga att cat ggg     1792
 Ser Gln Ser Thr Pro Ile Ser Gly Phe His Gln Thr Arg Ile His Gly
                 475                 480                 485

 ata aac aga gct ttc aaa aaa cct gta ttt tat tca gat ctt gat ggt     1840
 Ile Asn Arg Ala Phe Lys Lys Pro Val Phe Tyr Ser Asp Leu Asp Gly
             490                 495                 500

 aac tat gaa aaa ata agg att ttc cct gaa aat gac aaa cag caa gcc     1888
 Asn Tyr Glu Lys Ile Arg Ile Phe Pro Glu Asn Asp Lys Gln Gln Ala
         505                 510                 515

 agc cca agc tgt cca aaa aaa tat aaa aac acc tag ccag aaaatcagaa     1938
 Ser Pro Ser Cys Pro Lys Lys Tyr Lys Asn Thr 
     520                 525

 gccctattgt atgtggtgtt tcacaaccag acgttttcaa tccctaccct tttgctgagt   1998

 gccatgaaac tgatagtgat gaatgggtcc ctcctaccac acaaaaaata tttccttcag   2058

 atatgcttgg attccaaggc ataggtctag ggaaatgcct tggtgcctat catttccctg   2118

 atcaacaaga gttaccaaga aagaaac                                       2145




      <210> 306
      <211> 1339
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (570)..(1193)

      <400> 306
 ccttcgcccg cccctgcgtt ttgatccgcg tgcgtgaatt ctgcacgatc aatgattgat     60

 aatttgtgac actgtaaatc ctgaggttta tagaaaggat tcatgacttt gtaatggagt    120

 taggatccat cagagaagca gaactacttt gtgagctaaa gacctatgga attgtgggag    180

 gtggcagagc ggtctgcaga cttgcctctg agtctcttgt tcagcctgaa gttgctgcag    240

 atctactaga ctggcagtca gacagggata ctggatgtgg atgagagaaa agacaaactg    300

 aaacccttgg gaacaaaacg gaacctgcat cagcctctca ccaaccctag ttttgatgct    360

 tgagtaacct gcaggagagg atgacacttt cgatgtcaga gctgcacttg tgggcccagg    420

 atttggagaa gtggagagaa ggtctgatgg gagttgaagg agctgcaggt ccagcttctt    480

 ccccatgcca gcaagggtgc tggaaatgta aacaagaata gactgttcat tcctgatggc    540

 ttttagtcta tactaacata ttgtttgtc  atg gca tcc gag act gaa aag acc     593
                                  Met Ala Ser Glu Thr Glu Lys Thr
                                    1               5

 cat gct tta ctg cag act tgt agc act gaa tct ctt att tcc agc ctt      641
 His Ala Leu Leu Gln Thr Cys Ser Thr Glu Ser Leu Ile Ser Ser Leu
      10                  15                  20

 ggt ctg ggg gca ttt tgc ctc gta gct gac aga ctt ctt cag ttt tcc      689
 Gly Leu Gly Ala Phe Cys Leu Val Ala Asp Arg Leu Leu Gln Phe Ser
  25                  30                  35                  40

 aca att cag caa aat gac tgg ctt cgt gct ctc tca gat aat gca gta      737
 Thr Ile Gln Gln Asn Asp Trp Leu Arg Ala Leu Ser Asp Asn Ala Val
                  45                  50                  55

 cat tgt gta att ggc atg tgg tca tgg gcg gta gtc act gga atc aag      785
 His Cys Val Ile Gly Met Trp Ser Trp Ala Val Val Thr Gly Ile Lys
              60                  65                  70

 aag aag act gac ttt gga gaa atc att tta gct gga ttt tta gcc tct      833
 Lys Lys Thr Asp Phe Gly Glu Ile Ile Leu Ala Gly Phe Leu Ala Ser
          75                  80                  85

 gtt att gat gta gac cac ttt ttt cta gct gga tcc atg tct tta aag      881
 Val Ile Asp Val Asp His Phe Phe Leu Ala Gly Ser Met Ser Leu Lys
      90                  95                 100

 gct gct ttg act ctc ccg cga aga cct ttc ctt cac tgt tct act gtg      929
 Ala Ala Leu Thr Leu Pro Arg Arg Pro Phe Leu His Cys Ser Thr Val
 105                 110                 115                 120

 att ccc gtt gtg gtt ctg acc ctg aaa ttt act atg cac ctt ttc aag      977
 Ile Pro Val Val Val Leu Thr Leu Lys Phe Thr Met His Leu Phe Lys
                 125                 130                 135

 ctc aaa gac tca tgg tgc ttt ctt ccc tgg atg tta ttt ata tcc tgg     1025
 Leu Lys Asp Ser Trp Cys Phe Leu Pro Trp Met Leu Phe Ile Ser Trp
             140                 145                 150

 act tca cat cat atc cga gat ggg att cgt cat ggt ttg tgg ata tgc     1073
 Thr Ser His His Ile Arg Asp Gly Ile Arg His Gly Leu Trp Ile Cys
         155                 160                 165

 cca ttt gga aaa act tct cct ttg cca ttc tgg ctt tat gta ata atc     1121
 Pro Phe Gly Lys Thr Ser Pro Leu Pro Phe Trp Leu Tyr Val Ile Ile
     170                 175                 180

 aca tca tct tta cct cac att ctg tgc ctt cgg tct gta ttc acc gga     1169
 Thr Ser Ser Leu Pro His Ile Leu Cys Leu Arg Ser Val Phe Thr Gly
 185                 190                 195                 200

 ccg aca atg gtg ttt tca acc tga gtccgtcgag tcgagccggc agttaaaagg    1223
 Pro Thr Met Val Phe Ser Thr 
                 205

 aagcaagatg taataaaggg ccatagattc aaaaaggggg taattaggat aacgaccctg   1283

 ccgacgtact tcaactggtt tacttcagca gaagtcacca acatcgcttg gccaaa       1339




      <210> 307
      <211> 912
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (564)..(851)

      <400> 307
 caacttttat taaaccaaat ccagtaactt ttacaatgcc ttactagagg gttgcctcat     60

 aactgaacct tcatttctgg cagggaagaa accatggctt caggatcatg actgaagttt    120

 ggccatgttc catcattaat gttccaacat caccagggac acaaagctca gcatgagggc    180

 ttctacccaa atctccctac gacaggtact tcttcaactc ttccaccacc tcttgaggct    240

 cagggaattt gagtttgcgt gggggcccct tcttaatccc agtccagagc tccgcactgc    300

 tgccgtccgg gcgcagcagc gtcacctcga agctgcccct ccggggcttc gtcgggttca    360

 cctttactgg aagctctggg gcctccaggc gcagcgcctg gctcagggcc gcggcgttgc    420

 gcccatagac gcgtcagcta gtgcaatgct cgataacaac ggtcgcctcc tccattccct    480

 ccccgccgtt cgccagcttc tctcgcttct cggctacggc gaccaccgcg gcctcagcct    540

 tacgcttcct cccgcgggga gcc    atg gcg cct aga gcc cgg ccg aga atg     590
                              Met Ala Pro Arg Ala Arg Pro Arg Met
                                1               5

 cag cgg gac tgg tgg gtg ggg ggc gga gac gcg acc act gag cgg aaa      638
 Gln Arg Asp Trp Trp Val Gly Gly Gly Asp Ala Thr Thr Glu Arg Lys
  10                  15                  20                  25

 ctg ggc aac gaa gag cgc agc ccg gaa gct ctg ctc cta cag cgg aaa      686
 Leu Gly Asn Glu Glu Arg Ser Pro Glu Ala Leu Leu Leu Gln Arg Lys
                  30                  35                  40

 cct ctc tca aag gaa ggg aaa gct tgg ccc gca gca ccc acg tgg cct      734
 Pro Leu Ser Lys Glu Gly Lys Ala Trp Pro Ala Ala Pro Thr Trp Pro
              45                  50                  55

 gga ggc gga cct tgg ggc aca acc act ttg caa gca ggg agc ggg aag      782
 Gly Gly Gly Pro Trp Gly Thr Thr Thr Leu Gln Ala Gly Ser Gly Lys
          60                  65                  70

 gtg cgg gaa gcg cct gac gga acc acc cat cgc ttc ggg tgg agg gga      830
 Val Arg Glu Ala Pro Asp Gly Thr Thr His Arg Phe Gly Trp Arg Gly
      75                  80                  85

 cag ggg acg ctg gga tgg tga ac acagcaggaa ggggcggaga ctaggtccga      883
 Gln Gly Thr Leu Gly Trp 
  90                  95

 ctgctagcct cgcttcgcgc aatcttttc                                      912




      <210> 308
      <211> 1077
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (551)..(1030)

      <400> 308
 agcggggggc tcgcgcgggg gaccgcgccc ggggatcctg caggggcggg aagggggctc     60

 gggctccttg cttccgccgc agtggggcgc tgccgggctc cccggcacta gcgctgctgg    120

 cggccccggc ggccgggcgt gctgcctgca agatgtccgt gcgccgcggc cggcggccgg    180

 cgcggccggg gacccgcctc tcctggctgc tgtgctgcag cgccctgctg tccccggccg    240

 cgggctacgt gatcgtgagc tccgttgtct tgggccgtca ccaacgaggt ggacgaggag    300

 ctggacagcg cctccactga ggaggctatg cccgcgctgc tagaggattc gggcagcatc    360

 tggcacgcaa agcttccccg cctctgccca caaggaggac gcgcacctgc ggccccgggc    420

 gggcgcctgc ccgggccagg cagccccccg cgccacccgg gatgttctcc tacacggcgc    480

 agagggccgg cagacggcca gtgcgccccc gggccctaga ctgcgcgccg caccgaccgc    540

 tccctggacc   atg cca gac gtc tgg ggc tgc ctg gcc acc gtg tcc acc     589
              Met Pro Asp Val Trp Gly Cys Leu Ala Thr Val Ser Thr
                1               5                  10

 cac aag aag atc caa gga ctg cca ttt ggg aac tgc ctg ccc gtc agt      637
 His Lys Lys Ile Gln Gly Leu Pro Phe Gly Asn Cys Leu Pro Val Ser
      15                  20                  25

 gat ggc ccc ttc aac aat agc act ggg att cct ttc ttc tac atg aca      685
 Asp Gly Pro Phe Asn Asn Ser Thr Gly Ile Pro Phe Phe Tyr Met Thr
  30                  35                  40                  45

 gcc aag gac ccc gtg gtg gct gat ctg atg aag aac ccc atg gcc tcg      733
 Ala Lys Asp Pro Val Val Ala Asp Leu Met Lys Asn Pro Met Ala Ser
                  50                  55                  60

 ctg atg ctg cca gaa tca gaa ggg gag ttc tgc aga aaa aac atc gtt      781
 Leu Met Leu Pro Glu Ser Glu Gly Glu Phe Cys Arg Lys Asn Ile Val
              65                  70                  75

 gat ccg gaa gat ccc cga tgt gtc cag tta acg ctc act ggc cag atg      829
 Asp Pro Glu Asp Pro Arg Cys Val Gln Leu Thr Leu Thr Gly Gln Met
          80                  85                  90

 atc gca gtg tct cca gaa gaa gta gaa ttt gcc aag caa gcc atg ttt      877
 Ile Ala Val Ser Pro Glu Glu Val Glu Phe Ala Lys Gln Ala Met Phe
      95                 100                 105

 tca agg cac cca ggg atg agg aag tgg cct cgt caa tat gaa tgg ttc      925
 Ser Arg His Pro Gly Met Arg Lys Trp Pro Arg Gln Tyr Glu Trp Phe
 110                 115                 120                 125

 ttt atg aag atg agg ata gaa cat atc tgg ctt cag aaa tgg tat gga      973
 Phe Met Lys Met Arg Ile Glu His Ile Trp Leu Gln Lys Trp Tyr Gly
                 130                 135                 140

 ggc gca tcc agt att tca agg gag gaa tat ttc aaa gca gtt ccc aga     1021
 Gly Ala Ser Ser Ile Ser Arg Glu Glu Tyr Phe Lys Ala Val Pro Arg
             145                 150                 155

 aag gcc tga tggagtg agaagaaagt ccttggtgtt tgcacttaaa taaaaacctt     1077
 Lys Ala 






      <210> 309
      <211> 1355
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(853)

      <400> 309
 aaaa atg gca gcc gcc gct ccg gac tca cgt gtg agt gag gaa gaa aac      49
      Met Ala Ala Ala Ala Pro Asp Ser Arg Val Ser Glu Glu Glu Asn
        1               5                  10                  15

 ctg aaa aag acc cca aag aag aag atg aaa atg gta act gga gcc gta       97
 Leu Lys Lys Thr Pro Lys Lys Lys Met Lys Met Val Thr Gly Ala Val
                  20                  25                  30

 gcg tcg gtg ctg gaa gac gag gcc aca gac act tct gat agt gaa gga      145
 Ala Ser Val Leu Glu Asp Glu Ala Thr Asp Thr Ser Asp Ser Glu Gly
              35                  40                  45

 agc tgt gga tcg gaa aag gac cac ttt tat tct gat gat gac gca ata      193
 Ser Cys Gly Ser Glu Lys Asp His Phe Tyr Ser Asp Asp Asp Ala Ile
          50                  55                  60

 gaa gct gac agt gag ggt gat gct gag ccc tgt gac aaa gaa aat gaa      241
 Glu Ala Asp Ser Glu Gly Asp Ala Glu Pro Cys Asp Lys Glu Asn Glu
      65                  70                  75

 aat gat gga gaa tca agt gtt ggg act aat atg ggc tgg gca gat gct      289
 Asn Asp Gly Glu Ser Ser Val Gly Thr Asn Met Gly Trp Ala Asp Ala
  80                  85                  90                  95

 atg gct aaa gtc ctc aac aag aaa act cct gaa agt aaa cct act att      337
 Met Ala Lys Val Leu Asn Lys Lys Thr Pro Glu Ser Lys Pro Thr Ile
                 100                 105                 110

 ctg gtc aaa aat aag aag ctg gaa aag gaa aaa gaa aag tta aag caa      385
 Leu Val Lys Asn Lys Lys Leu Glu Lys Glu Lys Glu Lys Leu Lys Gln
             115                 120                 125

 gaa aga cta gag aaa ata aaa cag cgt gat aag agg ctg gag tgg gaa      433
 Glu Arg Leu Glu Lys Ile Lys Gln Arg Asp Lys Arg Leu Glu Trp Glu
         130                 135                 140

 atg atg tgc aga gta aag cca gat gtt gtc caa gac aaa gag aca gag      481
 Met Met Cys Arg Val Lys Pro Asp Val Val Gln Asp Lys Glu Thr Glu
     145                 150                 155

 aga aat ctt cag aga att gca aca agg ggt gtg gtg caa tta ttt aat      529
 Arg Asn Leu Gln Arg Ile Ala Thr Arg Gly Val Val Gln Leu Phe Asn
 160                 165                 170                 175

 gct gtt cag aaa cat caa aag aat gtt gat gaa aag gtt aag gaa gct      577
 Ala Val Gln Lys His Gln Lys Asn Val Asp Glu Lys Val Lys Glu Ala
                 180                 185                 190

 gga agt tct atg aga aag cgt gct aag ttg ata tca act gtt tcc aag      625
 Gly Ser Ser Met Arg Lys Arg Ala Lys Leu Ile Ser Thr Val Ser Lys
             195                 200                 205

 aaa gat ttc atc agt gtt ttg aga ggg atg gat gga agt aca aat gag      673
 Lys Asp Phe Ile Ser Val Leu Arg Gly Met Asp Gly Ser Thr Asn Glu
         210                 215                 220

 act gct tca agc agg aag aaa cca aaa gcc aaa cag act gaa gtg aaa      721
 Thr Ala Ser Ser Arg Lys Lys Pro Lys Ala Lys Gln Thr Glu Val Lys
     225                 230                 235

 tca gaa gaa ggc cca ggt tgg acg atc cta cgt gat gat ttc atg atg      769
 Ser Glu Glu Gly Pro Gly Trp Thr Ile Leu Arg Asp Asp Phe Met Met
 240                 245                 250                 255

 gga gca tct atg aaa gac tgg gac aag gaa agt gat ggg cca gat gac      817
 Gly Ala Ser Met Lys Asp Trp Asp Lys Glu Ser Asp Gly Pro Asp Asp
                 260                 265                 270

 agc aga cca gaa tct gca agt gac tct gat aca taa agca tcataggaaa      867
 Ser Arg Pro Glu Ser Ala Ser Asp Ser Asp Thr 
             275                 280

 tacaattgca gtcgttttat tttttctaga aaaatatgtc atcctctgat agttggggaa    927

 ttataaggat accatttgta agaaagccaa aagacttttg ccagatttca tatttcccct    987

 tttcatgtac actttatata tacttcatta aaattatatt ttaaaccctt gtataatttt   1047

 aagcattgtt cctcagaaca tttgtaaaag gatatatttc tgcttgacca gcgagatgtg   1107

 cattttgcca ggatcatatt ggtcatgtct attggtgtat tatttcagta tcaccaatgt   1167

 tttcagaaat acagtactaa ttcatcatta aactctttga agttaatatt tttctgcctt   1227

 ctaacttata gactcaacta tgtatctgta gtttttggga atggttggtg ttttttgctt   1287

 tgtgttggga agttattgag aaaacctata taataaaatt taaaattata gtttttcaaa   1347

 aaaaaaaa                                                            1355




      <210> 310
      <211> 427
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (177)..(395)

      <400> 310
 tttcgtgcac ctgtgaggtg gaaggggatg cttttatgat cacttcctga aagagaggct     60

 cacagaactg aactgatgtg cttgtcatca cacagtggag gactgtctaa caccaagtct    120

 ctcattccct tggtggccag cccctctcag acctcagcaa gtccctctgg gccttc        176                                                                 
 atg gga gag cag tgt cca agg aat gcg gtg tca cgc ttg cgg ctc tgc      224
 Met Gly Glu Gln Cys Pro Arg Asn Ala Val Ser Arg Leu Arg Leu Cys
   1               5                  10                  15

 caa ggg ctt ctt ctt cgg gct ctg cct cta gct gct tct gac aga ggc      272
 Gln Gly Leu Leu Leu Arg Ala Leu Pro Leu Ala Ala Ser Asp Arg Gly
              20                  25                  30

 gga ttc atc atg aag caa acg cgg ctg aac ccc cca gtg gtc ttc att      320
 Gly Phe Ile Met Lys Gln Thr Arg Leu Asn Pro Pro Val Val Phe Ile
          35                  40                  45

 ctt ctc caa ccc ctt tca aga ccc agg gat ggg ctc agc aat tct gtt      368
 Leu Leu Gln Pro Leu Ser Arg Pro Arg Asp Gly Leu Ser Asn Ser Val
      50                  55                  60

 tta ata att ttg cat tct gtc cct taa atcat aaagagagcc cccaatctgt      420
 Leu Ile Ile Leu His Ser Val Pro 
  65                  70

 aacgaaa                                                              427




      <210> 311
      <211> 912
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (139)..(444)

      <400> 311
 tttcgtctgc ttccctcctc caggggttca ggtgctatgc atatttctct tctgtcccag     60

 gagtttagat aagcactcag cctgtgcttg cacttggggc cggtcggggg gagcctcagg    120

 gaggtgaagg ccaggcag  atg tgc act tcc tgg gca gcc tcc cca gac agc     171
                      Met Cys Thr Ser Trp Ala Ala Ser Pro Asp Ser
                        1               5                  10

 ggg agg cct ggg aat ttg ggc cta gaa caa agc ctc tct gct ggg agc      219
 Gly Arg Pro Gly Asn Leu Gly Leu Glu Gln Ser Leu Ser Ala Gly Ser
              15                  20                  25

 aca aac agg ctg cca aga atg tcg ctc cac tgg ttc ctg cgc ctg ccc      267
 Thr Asn Arg Leu Pro Arg Met Ser Leu His Trp Phe Leu Arg Leu Pro
          30                  35                  40

 ctc aga gcc ctg ccc tgg gca atg tgg aag agc atc aac aga agg aga      315
 Leu Arg Ala Leu Pro Trp Ala Met Trp Lys Ser Ile Asn Arg Arg Arg
      45                  50                  55

 aaa tca atc aag ccc tgg aaa gcc aac ccc act ggc aca cgc agc cct      363
 Lys Ser Ile Lys Pro Trp Lys Ala Asn Pro Thr Gly Thr Arg Ser Pro
  60                  65                  70                  75

 cgt cct ctc cac tcc ttc aca gct cct cag ata atc tgc ccc att ggt      411
 Arg Pro Leu His Ser Phe Thr Ala Pro Gln Ile Ile Cys Pro Ile Gly
                  80                  85                  90

 ttc agg cct tta tgc att ttg ttt ggt ttc tag aggctggc ctgggcttgt      462
 Phe Arg Pro Leu Cys Ile Leu Phe Gly Phe 
              95                 100

 ttcatggtaa ccaggcagct ttttttgcaa agcagaagtg tgcagggcct ctcaaggcct    522

 tctctgagaa tgggcacagt gttccttcca ctgtgaccac acggccagcc cagagtcaag    582

 gaatatacag acagttgcca cctaccaggt gcccccgaac aaggggtcac actgatgatt    642

 gttactgcaa gttgtggcct agaacctggg tcccctggtt cctagttcag tcctcttccc    702

 gcttcatcaa tggccactca ataagcttcc agatccagat caactcatac ccaaaacagg    762

 aaggaatgtc aggtctggag aagcgagctg ggataagtga acaccaccga acgtctgtgg    822

 atgtccacgc ggtgacctgc tgggtgctag aaagagccag tgaaacacac cgggcatctt    882

 ctctatggaa gccagtttta actgctgtgt                                     912




      <210> 312
      <211> 533
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(509)

      <400> 312
 gagggagtgg catttgtgga aaccag atg tgc tgg cag ctt agg ggg aag tgg      53
                              Met Cys Trp Gln Leu Arg Gly Lys Trp
                                1               5

 cag tgt ggg gtg ggg gat ttt gca ttg ggg ttg gtt cca ttt cgg cca      101
 Gln Cys Gly Val Gly Asp Phe Ala Leu Gly Leu Val Pro Phe Arg Pro
  10                  15                  20                  25

 cca gga ctg ccc ctc ccc cac tcc tcc caa ttc cta tgg agc ctc tct      149
 Pro Gly Leu Pro Leu Pro His Ser Ser Gln Phe Leu Trp Ser Leu Ser
                  30                  35                  40

 att tta cct ctt tcc gtg cat ccc tgc acc cgc cac acc ccc ttc agc      197
 Ile Leu Pro Leu Ser Val His Pro Cys Thr Arg His Thr Pro Phe Ser
              45                  50                  55

 tat gct ttt gga gtc ctg gat ggg aat ctg ggg gga gag agg aag gac      245
 Tyr Ala Phe Gly Val Leu Asp Gly Asn Leu Gly Gly Glu Arg Lys Asp
          60                  65                  70

 agg tca ggt ctc ccc cag ccc ctt ctg ctc ctg tct cct cgt gtc cgc      293
 Arg Ser Gly Leu Pro Gln Pro Leu Leu Leu Leu Ser Pro Arg Val Arg
      75                  80                  85

 att gct gga gct cca cct ccc tct tgg ttt ctc cgc acc cgc cca ttt      341
 Ile Ala Gly Ala Pro Pro Pro Ser Trp Phe Leu Arg Thr Arg Pro Phe
  90                  95                 100                 105

 tcc ttc tgt ctt tac ctg ctt cgt atc ctt tcc ctg ctg atg tgg ctg      389
 Ser Phe Cys Leu Tyr Leu Leu Arg Ile Leu Ser Leu Leu Met Trp Leu
                 110                 115                 120

 acc cct ctc cca ccc ctc cct gca ggc ggc tgg cca ggt ggg cag gtg      437
 Thr Pro Leu Pro Pro Leu Pro Ala Gly Gly Trp Pro Gly Gly Gln Val
             125                 130                 135

 cca gcc gga gct gta aat aga gcg ctg cgc ttt tgt gct ggt ttg tgc      485
 Pro Ala Gly Ala Val Asn Arg Ala Leu Arg Phe Cys Ala Gly Leu Cys
         140                 145                 150

 gtg tgc tgt att tct gtg ttt tga tagaagtcac acaaaaaaaa aaaa           533
 Val Cys Cys Ile Ser Val Phe 
     155                 160





      <210> 313
      <211> 843
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(483)

      <400> 313
 cagatactat agggcctgag gacagattct tggtcgcaga agcgagattg gctttatatc     60

 agccctcacc atgtttacca acgtcacttc tgtgctcccc tc   atg ggt ctc cca     114
                                                  Met Gly Leu Pro
                                                    1

 tct ccc att ctc cat gcc acc tcc acg ctg aga cca gac cag ttt tcc      162
 Ser Pro Ile Leu His Ala Thr Ser Thr Leu Arg Pro Asp Gln Phe Ser
   5                  10                  15                  20

 cca cac aca aat cca agc ctg tca ctc ccc tgc ttg aaa tcc ttc cct      210
 Pro His Thr Asn Pro Ser Leu Ser Leu Pro Cys Leu Lys Ser Phe Pro
                  25                  30                  35

 gtc tcc ctg tgg cct tgg ggt agg gcc tct ctg ctc tgc cac ctc tcc      258
 Val Ser Leu Trp Pro Trp Gly Arg Ala Ser Leu Leu Cys His Leu Ser
              40                  45                  50

 aga ctt ttt gtg tgc cac cgc cca ctc aca ccc acc tct cag gct cca      306
 Arg Leu Phe Val Cys His Arg Pro Leu Thr Pro Thr Ser Gln Ala Pro
          55                  60                  65

 aac atg ttc tct tgc gtc agc tca tcc ctt aca ctc gct gct tcc tct      354
 Asn Met Phe Ser Cys Val Ser Ser Ser Leu Thr Leu Ala Ala Ser Ser
      70                  75                  80

 gcc tgg cca gcc tcc cac ctt ccg atc tcc cac tca cct ttt ttg cct      402
 Ala Trp Pro Ala Ser His Leu Pro Ile Ser His Ser Pro Phe Leu Pro
  85                  90                  95                 100

 cct cat ctt ttg agg tct cag ctc agt gtc act tcc tcc cgg gag cct      450
 Pro His Leu Leu Arg Ser Gln Leu Ser Val Thr Ser Ser Arg Glu Pro
                 105                 110                 115

 cgc ctg tct ctt cca ctc cag ctt ggt cag tga gcagagag gcttgtgtgc      501
 Arg Leu Ser Leu Pro Leu Gln Leu Gly Gln 
             120                 125

 ttttctgtcg ctgtacccat aagtgtcatc tgcatgtgag catgagggcc ggcccattgt    561

 acccctaaca ggggaggatg ctcagcactt cctggatgtc gaatacctga gcgataaaca    621

 actaatgttc aggaagtgct ttccaggtgg caaaaggtgt ttcctctact ttgaagcaag    681

 aatcttcacc aatatacatg ctattttatt accccaattt actgatgagg aaactaagct    741

 tctgagactt caagcgattt tccaaggtca tgtagggata cacaagttcc agcatgtgat    801

 tgtggtaaag gttgtgtgtg acacatgagt gcaaccagag at                       843




      <210> 314
      <211> 1320
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1320)

      <400> 314
  atg aaa ctt gtt acc aag cac ttt cca ggt gaa ttt ggg agt gaa atc      48
  Met Lys Leu Val Thr Lys His Phe Pro Gly Glu Phe Gly Ser Glu Ile
    1               5                  10                  15

 cta gtt cag aaa gtt gtc cac act ata ttg cat cag act gcc aaa aag       96
 Leu Val Gln Lys Val Val His Thr Ile Leu His Gln Thr Ala Lys Lys
              20                  25                  30

 aat ccc gat gat tat act cct gta aat ata gat ggt gct cac gcc caa      144
 Asn Pro Asp Asp Tyr Thr Pro Val Asn Ile Asp Gly Ala His Ala Gln
          35                  40                  45

 aga gtt gga gat gtt caa gga caa gaa tca gag tct cag ctc cca act      192
 Arg Val Gly Asp Val Gln Gly Gln Glu Ser Glu Ser Gln Leu Pro Thr
      50                  55                  60

 aaa att att ctt act gga cag aaa aca aaa act ttg cac aag gag gag      240
 Lys Ile Ile Leu Thr Gly Gln Lys Thr Lys Thr Leu His Lys Glu Glu
  65                  70                  75                  80

 tta aac atg agt aaa act gaa aga act att caa cag aat att acg gaa      288
 Leu Asn Met Ser Lys Thr Glu Arg Thr Ile Gln Gln Asn Ile Thr Glu
                  85                  90                  95

 cag gct tct gta atg cag aaa cgg aaa aca gag aag tta aaa caa gaa      336
 Gln Ala Ser Val Met Gln Lys Arg Lys Thr Glu Lys Leu Lys Gln Glu
             100                 105                 110

 caa aaa ggg caa ccc agg act gtt tct ccc agt acc att cgt gat ggt      384
 Gln Lys Gly Gln Pro Arg Thr Val Ser Pro Ser Thr Ile Arg Asp Gly
         115                 120                 125

 cca tcc tct gca cct gct aca cct acc aag gct ccc tat tca ccg aca      432
 Pro Ser Ser Ala Pro Ala Thr Pro Thr Lys Ala Pro Tyr Ser Pro Thr
     130                 135                 140

 act tct aag gag aag aag atc cga atc aca act aat gat gga cga cag      480
 Thr Ser Lys Glu Lys Lys Ile Arg Ile Thr Thr Asn Asp Gly Arg Gln
 145                 150                 155                 160

 tcc atg gtt acc ctt aag tct tca aca acc ttt ttt gaa ctt cag gaa      528
 Ser Met Val Thr Leu Lys Ser Ser Thr Thr Phe Phe Glu Leu Gln Glu
                 165                 170                 175

 agt ata gcc aga gaa ttc aac att ttt cca tat tta cag tgt att cga      576
 Ser Ile Ala Arg Glu Phe Asn Ile Phe Pro Tyr Leu Gln Cys Ile Arg
             180                 185                 190

 tac ggg ttt cct cct aaa gag tta atg cca cca cag gca gga atg gaa      624
 Tyr Gly Phe Pro Pro Lys Glu Leu Met Pro Pro Gln Ala Gly Met Glu
         195                 200                 205

 aag gaa cca gtt cct tta cag cat ggc gac aga att aca ata gaa att      672
 Lys Glu Pro Val Pro Leu Gln His Gly Asp Arg Ile Thr Ile Glu Ile
     210                 215                 220

 cta aaa agt aaa gct gaa ggt ggt cag tct gct gca gca cac tca gcc      720
 Leu Lys Ser Lys Ala Glu Gly Gly Gln Ser Ala Ala Ala His Ser Ala
 225                 230                 235                 240

 cac act gtg aaa caa gaa gat att gct gtt act ggt aaa ctg tca tct      768
 His Thr Val Lys Gln Glu Asp Ile Ala Val Thr Gly Lys Leu Ser Ser
                 245                 250                 255

 aag gaa ctt cag gag caa gct gaa aaa gaa atg tac tcc ttg tgt ctt      816
 Lys Glu Leu Gln Glu Gln Ala Glu Lys Glu Met Tyr Ser Leu Cys Leu
             260                 265                 270

 tta gca aca tta atg gga gaa gat gta tgg tct tat gca aag gga ctt      864
 Leu Ala Thr Leu Met Gly Glu Asp Val Trp Ser Tyr Ala Lys Gly Leu
         275                 280                 285

 cct cac atg ttt cag cag ggt ggt gta ttc tac agt att atg aag aaa      912
 Pro His Met Phe Gln Gln Gly Gly Val Phe Tyr Ser Ile Met Lys Lys
     290                 295                 300

 acc atg ggt atg gct gat ggc aag cat tgt act ttt cca cat ctg cct      960
 Thr Met Gly Met Ala Asp Gly Lys His Cys Thr Phe Pro His Leu Pro
 305                 310                 315                 320

 ggc aaa acc ttt gtc tat aat gct tct gaa gat aga ctg gaa ttg tgt     1008
 Gly Lys Thr Phe Val Tyr Asn Ala Ser Glu Asp Arg Leu Glu Leu Cys
                 325                 330                 335

 gtg gat gct gca gga cat ttc ccc att ggt cct gat gtt gaa gat tta     1056
 Val Asp Ala Ala Gly His Phe Pro Ile Gly Pro Asp Val Glu Asp Leu
             340                 345                 350

 gtt aaa gag gct gta agt cag gtt cga tca gag gct act aca aga agt     1104
 Val Lys Glu Ala Val Ser Gln Val Arg Ser Glu Ala Thr Thr Arg Ser
         355                 360                 365

 agg gaa tca agt ccc tca cat ggg cta tta aaa cta ggt agt ggt gga     1152
 Arg Glu Ser Ser Pro Ser His Gly Leu Leu Lys Leu Gly Ser Gly Gly
     370                 375                 380

 gta gtg aaa aag aaa tct gag caa ctt cat aac gta act gcc ttt cag     1200
 Val Val Lys Lys Lys Ser Glu Gln Leu His Asn Val Thr Ala Phe Gln
 385                 390                 395                 400

 gga aaa ggg cat tct tta gga act gca tct ggt aac cca cac ctt gat     1248
 Gly Lys Gly His Ser Leu Gly Thr Ala Ser Gly Asn Pro His Leu Asp
                 405                 410                 415

 cca aga gct agg gaa act tca gtt gta aga aag cat aat aca ggg aca     1296
 Pro Arg Ala Arg Glu Thr Ser Val Val Arg Lys His Asn Thr Gly Thr
             420                 425                 430

 gac ttt agt aat agt tcc acc taa                                     1320
 Asp Phe Ser Asn Ser Ser Thr 
         435





      <210> 315
      <211> 1157
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (513)..(770)

      <220>
      <221> misc_feature
      <222> (1)...(1157)
      <223> n = a,t,c or g

      <400> 315
 acagtcaaag tgctaggaaa cctgatagga tacttccctt tggcacaaaa acaccctggt     60

 gctacataca ggagtatgac cttgggtgaa tatgtggcac taattttttt taccttaatc    120

 atattcttgt caagtaggca acccattgcc cctgtggaga ccacaccagc cctgtaagtt    180

 ctcaccagca gcatggagat taggaagagg ggctgctgtg accaggagat acacacggct    240

 ttaagtaact gagagcctaa agaaaagtaa cccaggagtc cggtccagtt ttaatatttg    300

 tggatttgtt gtcacacaca ttgtttagtc ctgaaactaa aacctatttt ataaatagta    360

 gggttaattc ctcgaaacaa tttctttatt aataaatgtc ctgtgggttt agaaatatca    420

 ggtaacatat ttgaatacag aatgatgatt gcaattactg ttacaagcgt gaaacacaaa    480

 cttcagatca aatctagagt gtgcttcatt ta  atg cat gct agc aac agc ctt     533
                                      Met His Ala Ser Asn Ser Leu
                                        1               5

 aac ttt gga ttc agt tat ttg aaa cac ttt tcc ggc atc ttt ccc ttt      581
 Asn Phe Gly Phe Ser Tyr Leu Lys His Phe Ser Gly Ile Phe Pro Phe
          10                  15                  20

 cta atg ttg tgg ggt gga aac cgg atg gca aat cac tgt gag ccg gat      629
 Leu Met Leu Trp Gly Gly Asn Arg Met Ala Asn His Cys Glu Pro Asp
      25                  30                  35

 acc tca gca cag tcc acc ttg tgt gtg act tca caa atg ggg gac ttc      677
 Thr Ser Ala Gln Ser Thr Leu Cys Val Thr Ser Gln Met Gly Asp Phe
  40                  45                  50                  55

 aca aat ggg gta act gaa tgt tat tac ttt caa att ttg aca tgg agc      725
 Thr Asn Gly Val Thr Glu Cys Tyr Tyr Phe Gln Ile Leu Thr Trp Ser
                  60                  65                  70

 att atg atc aag gaa atg gag ctg cct tat aca tta aac ccg tga ttt      773
 Ile Met Ile Lys Glu Met Glu Leu Pro Tyr Thr Leu Asn Pro 
              75                  80                  85

 aatcctattg acattttcat agccatgcct ccagatttta tctttttggc aaaattctga    833

 ttccacagtt tggtctgatt gaaataaata ttccctggac gtctggctaa aaattttgct    893

 aacaatccca gaggtgccat tttcttatta ataaatttca ttggagcctt atttcttact    953

 atattcaatt tcgtttcaaa cctgcaagtc cctgggatgg tcccacgact agggcctgca   1013

 cattttttac aatggcanag cattttttaa aaattatggt caggtntgng acagaaggag   1073

 tagttaccac aatttgagcc agtattgatg caacgatgta aatttgaaat ttgccccttt   1133

 agtaangaag acccgcaaat ccat                                          1157




      <210> 316
      <211> 1437
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (216)..(1025)

      <400> 316
 cgcgcagaag tccggggctg gcaagcgctt cctgcgcagc gcctaggcga cctggagttt     60

 gtgacgctgt gatggtctag aggctggaga ttcaagatct gggtgccatc attttctggt    120

 tctgttgatg accctcttcc aggttacata cagcttacat cttgcatcct caagcgtttt    180

 tcttataagg ctaaaaattc acaaagcata tatca   atg aat cag gag gat cta     233
                                          Met Asn Gln Glu Asp Leu
                                            1               5

 gat ccg gat agt act aca gat gtg gga gat gtt aca aat act gaa gaa      281
 Asp Pro Asp Ser Thr Thr Asp Val Gly Asp Val Thr Asn Thr Glu Glu
              10                  15                  20

 gaa ctt att aga gaa tgt gaa gaa atg tgg aaa gat atg gaa gaa tgt      329
 Glu Leu Ile Arg Glu Cys Glu Glu Met Trp Lys Asp Met Glu Glu Cys
          25                  30                  35

 cag aat aaa tta tca ctt att gga act gaa aca ctc acc gat tca aat      377
 Gln Asn Lys Leu Ser Leu Ile Gly Thr Glu Thr Leu Thr Asp Ser Asn
      40                  45                  50

 gct cag cta tca ttg tta att atg caa gta aaa tgt tta acc gct gaa      425
 Ala Gln Leu Ser Leu Leu Ile Met Gln Val Lys Cys Leu Thr Ala Glu
  55                  60                  65                  70

 ctc agt caa tgg cag aaa aaa aca cct gaa aca att ccc ttg act gaa      473
 Leu Ser Gln Trp Gln Lys Lys Thr Pro Glu Thr Ile Pro Leu Thr Glu
                  75                  80                  85

 gac gtt ctc ata aca tta gga aaa gaa gag ttc caa aag ctg aga caa      521
 Asp Val Leu Ile Thr Leu Gly Lys Glu Glu Phe Gln Lys Leu Arg Gln
              90                  95                 100

 gat ctt gaa atg gta ctg tcc act aag gag tca aag aat gaa aag tta      569
 Asp Leu Glu Met Val Leu Ser Thr Lys Glu Ser Lys Asn Glu Lys Leu
         105                 110                 115

 aag gaa gac tta gaa agg gaa caa cgg tgg ttg gat gaa cag caa cag      617
 Lys Glu Asp Leu Glu Arg Glu Gln Arg Trp Leu Asp Glu Gln Gln Gln
     120                 125                 130

 ata atg gaa tct ctt aat gta cta cac agt gaa ttg aaa aat aag gtt      665
 Ile Met Glu Ser Leu Asn Val Leu His Ser Glu Leu Lys Asn Lys Val
 135                 140                 145                 150

 gaa aca ttt tct gaa tca aga atc ttt aat gaa ctg aaa act aaa atg      713
 Glu Thr Phe Ser Glu Ser Arg Ile Phe Asn Glu Leu Lys Thr Lys Met
                 155                 160                 165

 ctt aat ata aaa gaa tat aag gag aaa ctc ttg agt acc ttg ggc gag      761
 Leu Asn Ile Lys Glu Tyr Lys Glu Lys Leu Leu Ser Thr Leu Gly Glu
             170                 175                 180

 ttt cta gaa gac cat ttt cct ctg cct gat aga agt gtt aaa aag aaa      809
 Phe Leu Glu Asp His Phe Pro Leu Pro Asp Arg Ser Val Lys Lys Lys
         185                 190                 195

 aag aaa aac att caa gaa tca tct gta aac ctg ata aca ctg cat gta      857
 Lys Lys Asn Ile Gln Glu Ser Ser Val Asn Leu Ile Thr Leu His Val
     200                 205                 210

 atg tta gag att ctt ata aat aga tta ttt gat gtt cca cat gat cca      905
 Met Leu Glu Ile Leu Ile Asn Arg Leu Phe Asp Val Pro His Asp Pro
 215                 220                 225                 230

 tat gtc aaa att agt gat tcc ttt ggc cac ctt atg ttg agc tgc tgc      953
 Tyr Val Lys Ile Ser Asp Ser Phe Gly His Leu Met Leu Ser Cys Cys
                 235                 240                 245

 tgc gta atg gaa tgt gcc ttg aga cat cca gaa gat cca acc cga ata     1001
 Cys Val Met Glu Cys Ala Leu Arg His Pro Glu Asp Pro Thr Arg Ile
             250                 255                 260

 aga tta gaa gct ttc cat cag taa aaggatgttt tctttttttc acaccagtaa    1055
 Arg Leu Glu Ala Phe His Gln 
         265

 aaaattcttt atcattcaag gatatgggaa ccacaaggac tattgtggat aaaaaacatt   1115

 atttgcaaat taatgccgca ttaggccatt cttactttta tgcaaaatgg atgtgctggc   1175

 atcctaatat tcattttcaa atggtcattc ttatcaggag tgcttagtgt ttactatatg   1235

 gatagaatgc ggtggtaata ttctaggcta aagcattgat gttctactca tgaatattgg   1295

 gattcttgtg gatatgatat gttttaattt ataaaattac aattttatgc ttgggtcagt   1355

 gtgcttttta tgcattatgg ggggatacta cagggtaaga gaatcaggga ttaacatatg   1415

 gttactgttc agtgtaggat ac                                            1437




      <210> 317
      <211> 1514
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(968)

      <400> 317
 tgataacctt tttaaagtat agctcaattg tc  atg cag gac acc aaa gat gaa      53
                                      Met Gln Asp Thr Lys Asp Glu
                                        1               5

 cac agg ctt cac agt ggc aaa ctc tgt ctg att atc ctt aca tgt att      101
 His Arg Leu His Ser Gly Lys Leu Cys Leu Ile Ile Leu Thr Cys Ile
          10                  15                  20

 gca gag gat caa tat gcc aat gca ttt ttg cat gat gac aac atg aat      149
 Ala Glu Asp Gln Tyr Ala Asn Ala Phe Leu His Asp Asp Asn Met Asn
      25                  30                  35

 ttt cga gta aac tta cat aga atg cct atg aga cac agg aag aag gca      197
 Phe Arg Val Asn Leu His Arg Met Pro Met Arg His Arg Lys Lys Ala
  40                  45                  50                  55

 gca gac aag aat ctt ccc tgc cgt cct tta gta tgt gca gta ctg gac      245
 Ala Asp Lys Asn Leu Pro Cys Arg Pro Leu Val Cys Ala Val Leu Asp
                  60                  65                  70

 ctg atg gta gag ttt att gta aca cac atg atg aag gag ttt cct atg      293
 Leu Met Val Glu Phe Ile Val Thr His Met Met Lys Glu Phe Pro Met
              75                  80                  85

 gat ctc tat ata cgc tgc atc cag gta gta cac aaa ctg ctc tgc tac      341
 Asp Leu Tyr Ile Arg Cys Ile Gln Val Val His Lys Leu Leu Cys Tyr
          90                  95                 100

 cag aag aag tgt cgg gta cgc ctg cat tac acc tgg cgg gag ctc tgg      389
 Gln Lys Lys Cys Arg Val Arg Leu His Tyr Thr Trp Arg Glu Leu Trp
     105                 110                 115

 tca gcc ttg ata aat ttg ctg aag ttc ctt atg tca aat gag act gta      437
 Ser Ala Leu Ile Asn Leu Leu Lys Phe Leu Met Ser Asn Glu Thr Val
 120                 125                 130                 135

 ctt ttg gcc aaa cac aac att ttt aca tta gcc ctt atg att gtg aac      485
 Leu Leu Ala Lys His Asn Ile Phe Thr Leu Ala Leu Met Ile Val Asn
                 140                 145                 150

 cta ttt aat atg ttt atc aca tat ggc gac aca ttt ctg cca acc ccc      533
 Leu Phe Asn Met Phe Ile Thr Tyr Gly Asp Thr Phe Leu Pro Thr Pro
             155                 160                 165

 agc agc tat gat gaa ctt tac tat gag att atc cgc atg cac cag agc      581
 Ser Ser Tyr Asp Glu Leu Tyr Tyr Glu Ile Ile Arg Met His Gln Ser
         170                 175                 180

 ttt gac aac ctc tac tcc atg gtc ctg agg ctt tct acc aat gca ggc      629
 Phe Asp Asn Leu Tyr Ser Met Val Leu Arg Leu Ser Thr Asn Ala Gly
     185                 190                 195

 cag tgg aag gaa gca gct agc aag gtg acc cat gca ttg gtt aat atc      677
 Gln Trp Lys Glu Ala Ala Ser Lys Val Thr His Ala Leu Val Asn Ile
 200                 205                 210                 215

 aga gcc atc atc aac cac ttt aac ccc aaa att gag tcc tac gct gct      725
 Arg Ala Ile Ile Asn His Phe Asn Pro Lys Ile Glu Ser Tyr Ala Ala
                 220                 225                 230

 gtg aat cac ata tcc caa ctg tca gag gag cag gtg ctg gag gtg gtg      773
 Val Asn His Ile Ser Gln Leu Ser Glu Glu Gln Val Leu Glu Val Val
             235                 240                 245

 aga gcc aac tat gac acg ctc acg ctg aag ctg cag gat ggc ctg gac      821
 Arg Ala Asn Tyr Asp Thr Leu Thr Leu Lys Leu Gln Asp Gly Leu Asp
         250                 255                 260

 cag tat gag cgc tac tca gag cag cac aag gaa gct gcc ttc ttc aaa      869
 Gln Tyr Glu Arg Tyr Ser Glu Gln His Lys Glu Ala Ala Phe Phe Lys
     265                 270                 275

 gag ctg gtt cga tcc att agc acc aac gtc cgg aga aac ctg gcc ttc      917
 Glu Leu Val Arg Ser Ile Ser Thr Asn Val Arg Arg Asn Leu Ala Phe
 280                 285                 290                 295

 cac aca ctc agc caa gaa gtc ctg ctc aag gag ttc tcc act atc tcc      965
 His Thr Leu Ser Gln Glu Val Leu Leu Lys Glu Phe Ser Thr Ile Ser
                 300                 305                 310

 tga ggcc acgcctacct gagcagcctc tgactgccct tacccatgag gatcatgggc     1022
 


 tggaggggga gcgaggggag agggggctgc ccccgaggtt ggagagaaac acagatacca   1082

 agttctcttg gtgaagaccg cacttcaatg gagcttgggc agcaggggca ggagggtcaa   1142

 gccagggata atcttatttg gggaggaatg ggtgggcaca gtggggagag gcctccagga   1202

 atgtggggac ttccagagtg ggctccctaa acagcccctc acatttccaa tcttgaggtt   1262

 acaagctgta gctactgact aattttcggg agctggtgag gcaagcctca gggtaatgcc   1322

 agcaccctga aagtcagtgg ctctgctcgg cttctgaaaa cagatcaact ctcagatata   1382

 gctggagcta catcctgctt cctttgggcc tggggctgtg cttggcttga aatctgtgtc   1442

 ccctgcctgc actggcactt tgtccagtca tcgggacctt tggctcagat ttagggtaag   1502

 ataggaatag gg                                                       1514




      <210> 318
      <211> 810
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (38)..(613)

      <400> 318
 caacgcagta cacaagtgct agccctagca gctcgcg atg tgc ttc agc aga gca      55
                                          Met Cys Phe Ser Arg Ala
                                            1               5

 gac gct gcg gat aac tac cct ttt gga aca tgt caa cag agg aaa ctt      103
 Asp Ala Ala Asp Asn Tyr Pro Phe Gly Thr Cys Gln Gln Arg Lys Leu
              10                  15                  20

 ttt cct cac ttc cat ccc ccg aat ttg att ggg aac aag ttt gtc cct      151
 Phe Pro His Phe His Pro Pro Asn Leu Ile Gly Asn Lys Phe Val Pro
          25                  30                  35

 ctt agg gga tca ccc cac aga ggg cct ggg tgt tat ttt tca gat gga      199
 Leu Arg Gly Ser Pro His Arg Gly Pro Gly Cys Tyr Phe Ser Asp Gly
      40                  45                  50

 tat ggc ttg gca tac gac tta tct aag atc cca acc agt ata aaa gga      247
 Tyr Gly Leu Ala Tyr Asp Leu Ser Lys Ile Pro Thr Ser Ile Lys Gly
  55                  60                  65                  70

 tat act ttg gga gcc aga aca gct gtg agg ttt aag cca ata cag aag      295
 Tyr Thr Leu Gly Ala Arg Thr Ala Val Arg Phe Lys Pro Ile Gln Lys
                  75                  80                  85

 gaa atg aca cct cat gca ggc agg tac cag aaa gta agt cct cag cag      343
 Glu Met Thr Pro His Ala Gly Arg Tyr Gln Lys Val Ser Pro Gln Gln
              90                  95                 100

 gaa aaa cac aaa caa aat ttt gct cca ttt aat gtc ttg gtg cct cga      391
 Glu Lys His Lys Gln Asn Phe Ala Pro Phe Asn Val Leu Val Pro Arg
         105                 110                 115

 ttt aag aac tac cca aag gac act tac tat ccc agc cct ggt gca tac      439
 Phe Lys Asn Tyr Pro Lys Asp Thr Tyr Tyr Pro Ser Pro Gly Ala Tyr
     120                 125                 130

 aac cca gag aag aag cca ccg cca aaa att gcc tgg cca atg aaa ttt      487
 Asn Pro Glu Lys Lys Pro Pro Pro Lys Ile Ala Trp Pro Met Lys Phe
 135                 140                 145                 150

 gga tct cca gac tgg gct cag gtt cca tgt cta cag aaa aga acc cta      535
 Gly Ser Pro Asp Trp Ala Gln Val Pro Cys Leu Gln Lys Arg Thr Leu
                 155                 160                 165

 aaa gct gag ctg tcc aca gac aaa gac ttt aga aag cat cgg aac cgt      583
 Lys Ala Glu Leu Ser Thr Asp Lys Asp Phe Arg Lys His Arg Asn Arg
             170                 175                 180

 gtg gcc tac cta agc ctg tat tat aat tga g cggctgtaac taccttcacg      634
 Val Ala Tyr Leu Ser Leu Tyr Tyr Asn 
         185                 190

 tgctcctctt atacacagac tctccaggac tgaggacaga gctgctcttc ttcttctacg    694

 ttactgtggc cctcttgtct ggcagcctgg agcccaggga gggacagggg cttatagctg    754

 ctgtatgaga acataaagac tagtgcacag tgctatctcc atctaaaaaa aaaaaa        810




      <210> 319
      <211> 1208
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (124)..(450)

      <220>
      <221> misc_feature
      <222> (1)...(1208)
      <223> n = a,t,c or g

      <400> 319
 agcaaggcgc caccacgctt ctggttcata gcctgggggt gggaggtccc ctaggagctg     60

 gcccctacca tcaaatgagg agaagccaag ttctctgctt tctgcagaca gggcctcccc    120

 tgg  atg gga tct tcc tct gag gcg agc ttc aga tct gct caa gct tcc     168
      Met Gly Ser Ser Ser Glu Ala Ser Phe Arg Ser Ala Gln Ala Ser
        1               5                  10                  15

 tgc agt ggg gcc agg agg cag ggc ctg ggc agg gga gac cag aac ctc      216
 Cys Ser Gly Ala Arg Arg Gln Gly Leu Gly Arg Gly Asp Gln Asn Leu
                  20                  25                  30

 tcg gtg atg cct ccg aat ggc agg gct cag aca cac aca cct ggc tgg      264
 Ser Val Met Pro Pro Asn Gly Arg Ala Gln Thr His Thr Pro Gly Trp
              35                  40                  45

 gta agt ccc tgc agt gaa aac cga gac ggt ctt ttg cct gcc aca gcc      312
 Val Ser Pro Cys Ser Glu Asn Arg Asp Gly Leu Leu Pro Ala Thr Ala
          50                  55                  60

 ccg ggc aga ctc tgc tct cac cgt ggt gcc gac atc cca agt ttt cag      360
 Pro Gly Arg Leu Cys Ser His Arg Gly Ala Asp Ile Pro Ser Phe Gln
      65                  70                  75

 act cac cag gac cca gtg aca gca tct ggg tcc tca gag ctg cat gcg      408
 Thr His Gln Asp Pro Val Thr Ala Ser Gly Ser Ser Glu Leu His Ala
  80                  85                  90                  95

 gac tgt ccc cag ttc aga gca ttg gac aga gct ggg aac tga cagccct      457
 Asp Cys Pro Gln Phe Arg Ala Leu Asp Arg Ala Gly Asn 
                 100                 105

 gatcaatagt cccaagagga aggccagccc tcctcctcct cggaatcctg ggtttctagg    517

 aggcagaaag gttttctgag aaacaaggct tttggaagga aggtggtgcc tggctgcatc    577

 cacaaagtga gagctaaatg gagaggctga acaaaggacg catgtggagc gcatggggag    637

 ggaaggctgg ggtgcagggc tccgggcctg ctcttctgcg tccaccccgg atcctgcttt    697

 tgtccagatg ggcctcggag caccagtcac ttactccaag aagtcgtttc ctgtggccaa    757

 taatgaagat gacgcactcg gaagcttgtg ggctctgagg agggggtaag gatgcagggg    817

 ccatgcattc atcccagcac aggcagcgca tggctccgga agcagacaca ggccaggcct    877

 gggccaggag tctgccagga gccaggagcg cctacacctc cctggaggcc cacacttctc    937

 tccccagaag ctcacacgca gcgtctgagg tgcagggccc aggtgtgctg gggtgacaaa    997

 gccccgagct gtggtgatgg gagggaggaa gcgccggttt atgtctgttc tttgggctga   1057

 tttgctgtct ctgtctttgt ctctaatgtc ctttgcacca ctgaccttga ggagcctttt   1117

 gttcctcctg tcccagtttg ggttccatgg gaacctgagt ggcagcgtca tcactttgct   1177

 gaggtgaaat gcccntggat gccatgaata c                                  1208




      <210> 320
      <211> 815
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (238)..(594)

      <220>
      <221> misc_feature
      <222> (1)...(815)
      <223> n = a,t,c or g

      <400> 320
 atttgccctc gagnccagga ttccgcacga gcttgccatg ctgcgccatc tgcctnncca     60

 gggctgccag tcaaagatgt ggggcangga cttggagaaa acagagacaa gcagagggca    120

 gcagaggccc atggaaaggc ccggctctaa agccatggag ggccctgtgc tcagtcatgg    180

 agggacagca gtcagacccc tcccccatgt cttatccgta gacttgacca catcgtg       237                                                                 
 atg acg gtg aag agc atc aaa gac acc acc atg ttt tat tcc aag atc      285
 Met Thr Val Lys Ser Ile Lys Asp Thr Thr Met Phe Tyr Ser Lys Ile
   1               5                  10                  15

 ctg ggc atg gag gtc atg act ttt aag gaa gac cgg aaa gca ctg tgt      333
 Leu Gly Met Glu Val Met Thr Phe Lys Glu Asp Arg Lys Ala Leu Cys
              20                  25                  30

 ttt gga gac cag aaa ttt aac ctc cac gag gtg gga aag gaa ttt gaa      381
 Phe Gly Asp Gln Lys Phe Asn Leu His Glu Val Gly Lys Glu Phe Glu
          35                  40                  45

 ccc aaa gcc gct cac cca gtt cct ggc tcc ctg gac ata tgt ctg atc      429
 Pro Lys Ala Ala His Pro Val Pro Gly Ser Leu Asp Ile Cys Leu Ile
      50                  55                  60

 aca gag gtg cct ttg gag gaa atg atc cag cac ctc aag gct tgt gat      477
 Thr Glu Val Pro Leu Glu Glu Met Ile Gln His Leu Lys Ala Cys Asp
  65                  70                  75                  80

 gtc cct att gag gag ggg cca gtc ccc aga aca ggg gca aaa ggg cct      525
 Val Pro Ile Glu Glu Gly Pro Val Pro Arg Thr Gly Ala Lys Gly Pro
                  85                  90                  95

 atc atg tcc atc tac ttc cga gac ccc gac aga aat ctg att gag gtg      573
 Ile Met Ser Ile Tyr Phe Arg Asp Pro Asp Arg Asn Leu Ile Glu Val
             100                 105                 110

 tcc aac tac atc tcc tcg tga tg gaggctggac ctcctccatt ctgtccccct      626
 Ser Asn Tyr Ile Ser Ser 
         115

 tgatgtcgcc ctctcctttc cttcctgcaa acccccaccc aggcccagag atctccaaag    686

 actgaggact taggcacttc acacatcctg ctgagggggg acccaagaca ggtttgggac    746

 caaacctaca tgtctgtatg tcatcaaagt tggcctaata aatgcataac ctctcaatga    806

 aaaaaaaaa                                                            815




      <210> 321
      <211> 2439
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (414)..(1520)

      <400> 321
 gagccacgcg tccgccgcgg gcgaagcgtt tgttgactcg cgctggatag gaactgaggc     60

 tggacggtac cccttctgag ggcagagctg ggggaggagg gagggacgga gggagggaga    120

 gccgggcaga tcgcgacggg gagaaccatc caggtcgctc atttctctcc ggtgagaaaa    180

 cttcctcggg aagaccggaa actttttcct atgcgcgcgg agtctggggc ggaggcgagc    240

 ggcgggtgtg cgcgactcgg ggtgattcac gccggggacc ccaaggaggt gttggctacg    300

 tttgtggttt taagaaagcc tgagggcctg aaggcagccc ctggagaagc cctttccgag    360

 ggcattcgga accttctggt cctagaggtg aagctgaact gtcaccagga ctt   atg     416
                                                              Met
                                                                1

 acc cgc ggc ttc gct ccc att ctg ccc gtc gag ttc cac aag atg ggc      464
 Thr Arg Gly Phe Ala Pro Ile Leu Pro Val Glu Phe His Lys Met Gly
               5                  10                  15

 tcc ttc cgc agg cct aga ccg cgc ttc atg agc tcc ccc gtg ctc agc      512
 Ser Phe Arg Arg Pro Arg Pro Arg Phe Met Ser Ser Pro Val Leu Ser
          20                  25                  30

 gac ctt ccc cga ttc caa gca act cgg cag gct ctg cag ctg agc tcc      560
 Asp Leu Pro Arg Phe Gln Ala Thr Arg Gln Ala Leu Gln Leu Ser Ser
      35                  40                  45

 agc tca gcc tgg aac agc gtt cag act gct gtg atc aac gtt ttc aaa      608
 Ser Ser Ala Trp Asn Ser Val Gln Thr Ala Val Ile Asn Val Phe Lys
  50                  55                  60                  65

 ggg ggt ggc ttg caa agc aac gag ctc tat gcc ctg aac gaa aac atc      656
 Gly Gly Gly Leu Gln Ser Asn Glu Leu Tyr Ala Leu Asn Glu Asn Ile
                  70                  75                  80

 agg cgg ctg ttg aag agt gaa ctt gga tca ttc att aca gac tat ttt      704
 Arg Arg Leu Leu Lys Ser Glu Leu Gly Ser Phe Ile Thr Asp Tyr Phe
              85                  90                  95

 cag aac cag ctt ctt gca aaa gga ctg ttc ttt gtg gag gag aag atc      752
 Gln Asn Gln Leu Leu Ala Lys Gly Leu Phe Phe Val Glu Glu Lys Ile
         100                 105                 110

 aag ctg tgt gaa ggt gaa aat cgc att gag gtt ctg gct gaa gtc tgg      800
 Lys Leu Cys Glu Gly Glu Asn Arg Ile Glu Val Leu Ala Glu Val Trp
     115                 120                 125

 gac cac ttc ttc act gag act ctc cct acc ctg cag gca ata ttt tat      848
 Asp His Phe Phe Thr Glu Thr Leu Pro Thr Leu Gln Ala Ile Phe Tyr
 130                 135                 140                 145

 cca gtt cag ggc cag gag ctg act atc cgc cag atc tcc ctg ctg ggc      896
 Pro Val Gln Gly Gln Glu Leu Thr Ile Arg Gln Ile Ser Leu Leu Gly
                 150                 155                 160

 ttc cga gac cta gtc ttg ctg aag gtg aag ctg ggt gac ctg ctg ctg      944
 Phe Arg Asp Leu Val Leu Leu Lys Val Lys Leu Gly Asp Leu Leu Leu
             165                 170                 175

 ctg gcc cag tcc aag ctg ccc tcg tcc att gtc cag atg ttg ctc atc      992
 Leu Ala Gln Ser Lys Leu Pro Ser Ser Ile Val Gln Met Leu Leu Ile
         180                 185                 190

 ctg cag agt gtt cac gag ccc aca ggc cca agt gag agt tat ttg caa     1040
 Leu Gln Ser Val His Glu Pro Thr Gly Pro Ser Glu Ser Tyr Leu Gln
     195                 200                 205

 ctg gag gag ctg gtg aag caa gtg gtt tct cct ttc ctc ggc atc agc     1088
 Leu Glu Glu Leu Val Lys Gln Val Val Ser Pro Phe Leu Gly Ile Ser
 210                 215                 220                 225

 ggg gac cgt agc ttc tca ggc ccc acg tac acg ctg gcc agg cgg cac     1136
 Gly Asp Arg Ser Phe Ser Gly Pro Thr Tyr Thr Leu Ala Arg Arg His
                 230                 235                 240

 tcc agg gtc cgg ccc aag gtg act gtc ctg aac tat gcc tcc ccg ata     1184
 Ser Arg Val Arg Pro Lys Val Thr Val Leu Asn Tyr Ala Ser Pro Ile
             245                 250                 255

 acc gca gtc agc cgg cca ctg aat gag atg gtc ttg acc cca ctg aca     1232
 Thr Ala Val Ser Arg Pro Leu Asn Glu Met Val Leu Thr Pro Leu Thr
         260                 265                 270

 gag cag gag ggg gaa gcc tac ctg gag aag tgt ggc agc gtg cgg cgg     1280
 Glu Gln Glu Gly Glu Ala Tyr Leu Glu Lys Cys Gly Ser Val Arg Arg
     275                 280                 285

 cac acg gtg gcc aat gcc cac tcg gac atc cag ctg ctg gcc atg gcc     1328
 His Thr Val Ala Asn Ala His Ser Asp Ile Gln Leu Leu Ala Met Ala
 290                 295                 300                 305

 acc atg atg cac tcg ggc ctg ggg gag gag gcc agc agt gag aac aag     1376
 Thr Met Met His Ser Gly Leu Gly Glu Glu Ala Ser Ser Glu Asn Lys
                 310                 315                 320

 tgc ctg ctc ctg cca ccc agc ttc ccc ccg ccc cac cgg cag tgc tcc     1424
 Cys Leu Leu Leu Pro Pro Ser Phe Pro Pro Pro His Arg Gln Cys Ser
             325                 330                 335

 agt gag ccc aac atc acc gac aac cct gac gga ctg gag gag ggg gcc     1472
 Ser Glu Pro Asn Ile Thr Asp Asn Pro Asp Gly Leu Glu Glu Gly Ala
         340                 345                 350

 agg ggc agc cag gag ggc tcg gag ctg aac tgt gct tcc ctc agc tga     1520
 Arg Gly Ser Gln Glu Gly Ser Glu Leu Asn Cys Ala Ser Leu Ser 
     355                 360                 365

 gtcgccaccc ctgggccttt ccatctcctg ttttgcaacc aggatgagga cccctccatc   1580

 tccgtggatt actgaggggg gctcttgctt tatgcgatgc tgccttattt cctttagggt   1640

 actgtcctgg tcaaaatgac ctaaggggaa accgttgttg taaacctctt tattttggtg   1700

 actgtgacca cttctttgta gccaccaatt gtagtgacca gttgcctaat ggtcactttc   1760

 tgactccagc cttgccagcc tgactcagat cctcatctct gggcctttct ccctccgatg   1820

 ttggactgcc tgatgctccc aatgacatat ccaatgctcc tggcatttct ggagcaggag   1880

 gttgtcagga caacacatat aaccaccaag gatgtgttgg cctttggagt tcccctttag   1940

 gttcctagtg atgtggaggt ttatgggtga aaaattagtg gagagggaac tcctctcccc   2000

 cattttgtgt agagtgaaaa tagcctgaag cccctactca gcagggctct gggaatgtgc   2060

 cttccttatt ttagtttcag aattgctggg aaagttaccc cactggtggg tgaggatcta   2120

 tcctcaacct acatccagat cctatgtgct gcttgcacag aggcctttgg cttttgaccc   2180

 aggagggccg cgaggctgga gctgccctgt ctttcattga gccttagcat ttccctctca   2240

 ggcttcctct caagctcaag gaactcaccc ccagataaga agctggtgcc tcttgtctct   2300

 ctcatttcag aaacggactt tctcatcatg ctttcctatg gtgggtatga ggggccagct   2360

 gataccaacc aactggcctg tatctatcta tctggatttg acttgaattt ttaaaatgtg   2420

 tatcgtttaa aaaaaaaaa                                                2439




      <210> 322
      <211> 2129
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (186)..(1691)

      <400> 322
 tgtcgttgtt ctgagacgaa atcgtcgaca ggaaggccac cctgagccgc gtgcgggagc     60

 tcaagcagac gctgttcact ccctcctacg gcgtggtgcc ctgctgcacc agcctagaga    120

 agctgctgct ctacttcgag attctggacc gcacgcgcga gggcgccatc ctctcgggcc    180

 agctt    atg gtg ggc cag agc aac gtg ccg cac tac cag cac ctg cgg     227
          Met Val Gly Gln Ser Asn Val Pro His Tyr Gln His Leu Arg
            1               5                  10

 gtc ttc tat gcg cgc ctg gcc ccc ggc tac atc aac cag gag gtg gtg      275
 Val Phe Tyr Ala Arg Leu Ala Pro Gly Tyr Ile Asn Gln Glu Val Val
  15                  20                  25                  30

 cgg ctc tac ctg gct gcg ctt agc gac cgc act cct cag aac ctc cac      323
 Arg Leu Tyr Leu Ala Ala Leu Ser Asp Arg Thr Pro Gln Asn Leu His
                  35                  40                  45

 gcc ttc ctc atc tcc gtc cct ggc agc ttc gcg gag agc ggc gcc acc      371
 Ala Phe Leu Ile Ser Val Pro Gly Ser Phe Ala Glu Ser Gly Ala Thr
              50                  55                  60

 aag aac ctc ctg gac tcc atg gcg cgc aat gtc gtg ctg gat gcc ctg      419
 Lys Asn Leu Leu Asp Ser Met Ala Arg Asn Val Val Leu Asp Ala Leu
          65                  70                  75

 cag ctg ccc aag tcc tgg ctg aac ggc tct tcc ctc ctg cag cac atg      467
 Gln Leu Pro Lys Ser Trp Leu Asn Gly Ser Ser Leu Leu Gln His Met
      80                  85                  90

 aaa ttc aac aac ccg ttc tac ttc agt ttc agc cgc tgt acc ctg tca      515
 Lys Phe Asn Asn Pro Phe Tyr Phe Ser Phe Ser Arg Cys Thr Leu Ser
  95                 100                 105                 110

 ggc ggc cat ctg atc cag cag gtc atc atc ggc ggg aag gac ctg cgg      563
 Gly Gly His Leu Ile Gln Gln Val Ile Ile Gly Gly Lys Asp Leu Arg
                 115                 120                 125

 agc ctg gcc agc ttg aac ctc agc ggc tgc gtc cac tgc ctg tcc cca      611
 Ser Leu Ala Ser Leu Asn Leu Ser Gly Cys Val His Cys Leu Ser Pro
             130                 135                 140

 gac tcg ctg ctc cgc aag gcg gag gac gac atc gtc agc agc atc ctg      659
 Asp Ser Leu Leu Arg Lys Ala Glu Asp Asp Ile Val Ser Ser Ile Leu
         145                 150                 155

 gag acg ctg gtg gcg tcc tgc tgc aac ctg cgc cac ctg aac ctc tcg      707
 Glu Thr Leu Val Ala Ser Cys Cys Asn Leu Arg His Leu Asn Leu Ser
     160                 165                 170

 gcc gcc cac cac cac agc tcg gag ggc ctg ggc cgc cac ctc tgc cag      755
 Ala Ala His His His Ser Ser Glu Gly Leu Gly Arg His Leu Cys Gln
 175                 180                 185                 190

 ctc ctg gcc cgg ctg cgt cac ctg cgc tcc ctc tcc ctg cct gtc tgc      803
 Leu Leu Ala Arg Leu Arg His Leu Arg Ser Leu Ser Leu Pro Val Cys
                 195                 200                 205

 tct gtc gct gac tcc gcg ccg cgc gcc gac cgc gcg ccc gcc cag ccg      851
 Ser Val Ala Asp Ser Ala Pro Arg Ala Asp Arg Ala Pro Ala Gln Pro
             210                 215                 220

 gcc atg cac gca gtg ccg cgc ggc ttt ggc aag aaa gtg cgt gtg ggc      899
 Ala Met His Ala Val Pro Arg Gly Phe Gly Lys Lys Val Arg Val Gly
         225                 230                 235

 gtg cag tcc tgt ccc agc ccc ttc tcg ggc cag gcg tgc ccc cag ccc      947
 Val Gln Ser Cys Pro Ser Pro Phe Ser Gly Gln Ala Cys Pro Gln Pro
     240                 245                 250

 tcc tcc gtg ttc tgg tct ctg ctg aag aac ctg ccc ttc ctg gaa cac      995
 Ser Ser Val Phe Trp Ser Leu Leu Lys Asn Leu Pro Phe Leu Glu His
 255                 260                 265                 270

 ctc gag ctg att ggg tcc aac ttc tcc tcc gcc atg ccc cgc aac gag     1043
 Leu Glu Leu Ile Gly Ser Asn Phe Ser Ser Ala Met Pro Arg Asn Glu
                 275                 280                 285

 ccc gcc atc cgc aac tcg ctc cca ccc tgc agc cgc gca cag agt gtc     1091
 Pro Ala Ile Arg Asn Ser Leu Pro Pro Cys Ser Arg Ala Gln Ser Val
             290                 295                 300

 ggg gac tcg gag gtg gcc gcc atc ggc cag ctg gcc ttc ctg cgg cac     1139
 Gly Asp Ser Glu Val Ala Ala Ile Gly Gln Leu Ala Phe Leu Arg His
         305                 310                 315

 ctg acg ctc gca cag ctg ccc agc gtc ctt acg ggc tcc ggg ctg gtc     1187
 Leu Thr Leu Ala Gln Leu Pro Ser Val Leu Thr Gly Ser Gly Leu Val
     320                 325                 330

 aat atc ggc ctg cag tgc cag cag ttg cgg tcc ctg tcg ctg gcc aac     1235
 Asn Ile Gly Leu Gln Cys Gln Gln Leu Arg Ser Leu Ser Leu Ala Asn
 335                 340                 345                 350

 ctg ggc atg atg ggg aag gtg gtg tac atg ccc gcg ctc tca gac atg     1283
 Leu Gly Met Met Gly Lys Val Val Tyr Met Pro Ala Leu Ser Asp Met
                 355                 360                 365

 ttg aag cac tgc aag cgg ctg agg gac ctc agg ctg gag cag ccc tac     1331
 Leu Lys His Cys Lys Arg Leu Arg Asp Leu Arg Leu Glu Gln Pro Tyr
             370                 375                 380

 ttc agc gcc aac gcc cag ttc ttc cag gcg ctg agc cag tgc ccc tcg     1379
 Phe Ser Ala Asn Ala Gln Phe Phe Gln Ala Leu Ser Gln Cys Pro Ser
         385                 390                 395

 ctg cag cgc ctg tgc ctg gtc tct cgc agc ggc acc ctc cag ccc gat     1427
 Leu Gln Arg Leu Cys Leu Val Ser Arg Ser Gly Thr Leu Gln Pro Asp
     400                 405                 410

 gcc gtg ctg gcc ttc atg gct cgc tgc ctg cag gtt gtc atg tgc cac     1475
 Ala Val Leu Ala Phe Met Ala Arg Cys Leu Gln Val Val Met Cys His
 415                 420                 425                 430

 ctg ttc acc ggg gag tcc ctc gcc acc tgc aag agc ctg cag cag tcg     1523
 Leu Phe Thr Gly Glu Ser Leu Ala Thr Cys Lys Ser Leu Gln Gln Ser
                 435                 440                 445

 ctt ctc cgc agc ttc cag gcc gag cgg ccc gcg tta aac gtc gtc atc     1571
 Leu Leu Arg Ser Phe Gln Ala Glu Arg Pro Ala Leu Asn Val Val Ile
             450                 455                 460

 ttc cct ctg ctc cac gag ggc ctg acc gac gtc atc cgg gac gtc ccc     1619
 Phe Pro Leu Leu His Glu Gly Leu Thr Asp Val Ile Arg Asp Val Pro
         465                 470                 475

 ctg gtg cac ctg gat gag atc acc tta ttt aag agc aga gtg gcc gag     1667
 Leu Val His Leu Asp Glu Ile Thr Leu Phe Lys Ser Arg Val Ala Glu
     480                 485                 490

 gaa ccg ccg aac ctg tgg tgg tga gaggcggagc cgccgcccat cggtctcagt    1721
 Glu Pro Pro Asn Leu Trp Trp 
 495                 500

 cacctcgaga agctgcagga gcctgggacg ccagggaccc ttggtttgtc acaagaggaa   1781

 gggggcctct ctcccggcca gccacgcccc acctggctcc tggggctccc ggcgtctcca   1841

 cggctctctc atggggactg ttgctctgtg aagtttgggt cgaggggatg cgttctgggt   1901

 gacatgaggg ggctcggggg acggtcgatg tggggggctg gctgaaccag gctgaccctt   1961

 ggggcctggc tggggggttt gtatactgag ccgcaatccc tgggggccct gtccacgggc   2021

 ctggagggcc cgaaccccct gccacttccg accgggaagc gtgtcccttg gctgttgtgt   2081

 ttgtggtcac ctgccaccgg ggccccgtgg atgggcggcc acatgctg                2129




      <210> 323
      <211> 895
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (546)..(719)

      <400> 323
 taatcacttc cccagccctt ccatagcctt ttttgaggat aagaaaccca aagttcccag     60

 agattaactt gcccaagatc acttggcctg gatttgagcc tgaggctcag actccaaaac    120

 ccacactcaa tttgctacat ctcccagggg tggggccaag gcagctgtga gcaaaaggag    180

 aagtatcagc ttctcaaggg cctagggttt gttggaaggg caaggcaagg gcaaaggggg    240

 atacagaaca agggggcaag taccagtgcc tgggatggac ccatccattc aggcaggggg    300

 tgtggggtgt cccctgtgct tagaaaccac ctagcatcat agctgcaaca gcactttatt    360

 gggatctgag tctacagttc acatagggag gtgaagccgt gggagaagca ggggtaaaaa    420

 aaaaaaaggg gggggacttc accccctagg gacagctgct tccaaaccta acaaaacccc    480

 agggtaagtc ctcgtgctgg gcctcgagcc agcaactcta gtcaaatccc aaggcaccgg    540

 tcagc    atg tgg gtc aag ggg ccc act atg ggg aca tac act caa gag     587
          Met Trp Val Lys Gly Pro Thr Met Gly Thr Tyr Thr Gln Glu
            1               5                  10

 gat gaa agc tct tta gct tca gaa tca gat tgc ctt ccc cag acc cca      635
 Asp Glu Ser Ser Leu Ala Ser Glu Ser Asp Cys Leu Pro Gln Thr Pro
  15                  20                  25                  30

 ccc caa aac agg ctc ctc tcc cat ctc ccc ctt cac agt gac aaa aca      683
 Pro Gln Asn Arg Leu Leu Ser His Leu Pro Leu His Ser Asp Lys Thr
                  35                  40                  45

 caa gcc cac atc cca ggg cct gtc tac ata aag tga catc agtgcagggc      733
 Gln Ala His Ile Pro Gly Pro Val Tyr Ile Lys 
              50                  55

 tggtgatttt gctctactgt gtgaaagata tctgaggaca ccaaacaagc caggacagag    793

 tccaccctcc aggagttaga taacgctggg atcttgggct gggccaggcc aaggccattc    853

 cctgtggggc agggtgtcag ccccggtggt ggtggtggtg gc                       895




      <210> 324
      <211> 1305
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (52)..(1305)

      <400> 324
 cactgcccgc gtccgtgccc ctgcggggag cgcgccgggg ctgccccccg a atg acg      57
                                                          Met Thr
                                                            1

 ggc gga agg ttc gac ttc gac gat ggc ggc acc tac tgc ggc ggc tgg      105
 Gly Gly Arg Phe Asp Phe Asp Asp Gly Gly Thr Tyr Cys Gly Gly Trp
           5                  10                  15

 gag gag ggc aag gcg cac ggg cat ggc atc tgc acg ggg ccc aag ggc      153
 Glu Glu Gly Lys Ala His Gly His Gly Ile Cys Thr Gly Pro Lys Gly
      20                  25                  30

 cag ggc gag tac tcg ggc tcc tgg tcg cac ggc ttc gag gtg gtc gga      201
 Gln Gly Glu Tyr Ser Gly Ser Trp Ser His Gly Phe Glu Val Val Gly
  35                  40                  45                  50

 ggc tac acc tgg ccc agc ggc aac acc tac cag ggc tac tgg gcg cag      249
 Gly Tyr Thr Trp Pro Ser Gly Asn Thr Tyr Gln Gly Tyr Trp Ala Gln
                  55                  60                  65

 ggc aag cgg cac ggg ctg ggg gtg gag acg aag ggc aag tgg atg tac      297
 Gly Lys Arg His Gly Leu Gly Val Glu Thr Lys Gly Lys Trp Met Tyr
              70                  75                  80

 cgg ggg gag tgg tca cat ggt ttc aag ggg cgc tac ggg gtc cgg cag      345
 Arg Gly Glu Trp Ser His Gly Phe Lys Gly Arg Tyr Gly Val Arg Gln
          85                  90                  95

 agc ctg tgc acc ccc gct cgc tac gag ggt acc tgg agt aac ggg ctg      393
 Ser Leu Cys Thr Pro Ala Arg Tyr Glu Gly Thr Trp Ser Asn Gly Leu
     100                 105                 110

 caa gac ggg tac ggc gtg gag acc tac ggg gac gga ggc ctg cgc cag      441
 Gln Asp Gly Tyr Gly Val Glu Thr Tyr Gly Asp Gly Gly Leu Arg Gln
 115                 120                 125                 130

 tgt gcg ctg gat ggt gca ggt gac ggt gca gct ctg ccc ccg act cac      489
 Cys Ala Leu Asp Gly Ala Gly Asp Gly Ala Ala Leu Pro Pro Thr His
                 135                 140                 145

 ggt gct ttc ttg cgg tct ctc caa ggt acc tac cag ggc cag tgg gcc      537
 Gly Ala Phe Leu Arg Ser Leu Gln Gly Thr Tyr Gln Gly Gln Trp Ala
             150                 155                 160

 gga ggc atg cgg cat ggc tac ggc gtg cgc cag agc gtg ccc tac ggc      585
 Gly Gly Met Arg His Gly Tyr Gly Val Arg Gln Ser Val Pro Tyr Gly
         165                 170                 175

 atg gcc acg gtg atc cgc tca ccg ctg cgt acc tcg ctg gcc tcg ctg      633
 Met Ala Thr Val Ile Arg Ser Pro Leu Arg Thr Ser Leu Ala Ser Leu
     180                 185                 190

 cgc agc gag cag agc aat ggc agc gtg ctc cac gac gcc gca gcc gcc      681
 Arg Ser Glu Gln Ser Asn Gly Ser Val Leu His Asp Ala Ala Ala Ala
 195                 200                 205                 210

 gcc gac agc ccg gcc ggc acc cgc ggc ggt ttc gtg ctc aac ttc cac      729
 Ala Asp Ser Pro Ala Gly Thr Arg Gly Gly Phe Val Leu Asn Phe His
                 215                 220                 225

 gca gac gct gag cta gcg ggc aag aag aag ggc ggc ctc ttc cgg agg      777
 Ala Asp Ala Glu Leu Ala Gly Lys Lys Lys Gly Gly Leu Phe Arg Arg
             230                 235                 240

 ggc tcc ctt ctt gga agc atg aaa ctt cgc aag tcc gaa tcc aag tct      825
 Gly Ser Leu Leu Gly Ser Met Lys Leu Arg Lys Ser Glu Ser Lys Ser
         245                 250                 255

 tcc atc tcg agc aag cgc agc tct gtc cgc agc gac gcg gcc atg agc      873
 Ser Ile Ser Ser Lys Arg Ser Ser Val Arg Ser Asp Ala Ala Met Ser
     260                 265                 270

 aga att agt tcc agc gat gcc aac tcc acg atc agc ttt ggc gat gta      921
 Arg Ile Ser Ser Ser Asp Ala Asn Ser Thr Ile Ser Phe Gly Asp Val
 275                 280                 285                 290

 gat tgt gat ttt tgc ccg gtg gaa gac cac gtg gac gcc acc acc acg      969
 Asp Cys Asp Phe Cys Pro Val Glu Asp His Val Asp Ala Thr Thr Thr
                 295                 300                 305

 gaa acc tac atg ggc gag tgg aag aac gac aag cgc aac ggc ttc ggc     1017
 Glu Thr Tyr Met Gly Glu Trp Lys Asn Asp Lys Arg Asn Gly Phe Gly
             310                 315                 320

 gtt agc gag cgc tcc aat ggc atg aag tat gaa ggg gag tgg gca aat     1065
 Val Ser Glu Arg Ser Asn Gly Met Lys Tyr Glu Gly Glu Trp Ala Asn
         325                 330                 335

 aac aag agg cat gga tat ggc tgt acc gtg ttt cct gac ggc tcc aaa     1113
 Asn Lys Arg His Gly Tyr Gly Cys Thr Val Phe Pro Asp Gly Ser Lys
     340                 345                 350

 gaa gag gga aaa tac aaa aat aat att ctg gtc cgt ggg ata agg aag     1161
 Glu Glu Gly Lys Tyr Lys Asn Asn Ile Leu Val Arg Gly Ile Arg Lys
 355                 360                 365                 370

 cag ctt ata cca ata aga cat aca aaa act agg gag aag gtg gac aga     1209
 Gln Leu Ile Pro Ile Arg His Thr Lys Thr Arg Glu Lys Val Asp Arg
                 375                 380                 385

 gca att gaa ggc gcc caa agg gca gct gcc atg gcc aga acc aaa gtg     1257
 Ala Ile Glu Gly Ala Gln Arg Ala Ala Ala Met Ala Arg Thr Lys Val
             390                 395                 400

 gaa ata gca aat tca aga aat gtt caa aag gtg gaa gag caa ctc taa     1305
 Glu Ile Ala Asn Ser Arg Asn Val Gln Lys Val Glu Glu Gln Leu 
         405                 410                 415





      <210> 325
      <211> 1611
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1611)

      <400> 325
  atg gcg aca ccg gac gcg ggg ctc cct ggg gct gag ggc gtg gag ccg      48
  Met Ala Thr Pro Asp Ala Gly Leu Pro Gly Ala Glu Gly Val Glu Pro
    1               5                  10                  15

 gcg ccc tgg gcg cag ctg gag gcc ccc gcc cgc ctc ctg ctg cag gcg       96
 Ala Pro Trp Ala Gln Leu Glu Ala Pro Ala Arg Leu Leu Leu Gln Ala
              20                  25                  30

 ctg cag gcg ggg cct gag ggg gcg cgg cgc ggc ctg ggg gtg ctc cgg      144
 Leu Gln Ala Gly Pro Glu Gly Ala Arg Arg Gly Leu Gly Val Leu Arg
          35                  40                  45

 gcg ctg ggc agc cgc ggc tgg gag ccc ttc gac tgg ggt cgc ttg ctc      192
 Ala Leu Gly Ser Arg Gly Trp Glu Pro Phe Asp Trp Gly Arg Leu Leu
      50                  55                  60

 gag gcc ctg tgc cgg gag gag ccg gtc gtg cag ggg cct gac ggc cgt      240
 Glu Ala Leu Cys Arg Glu Glu Pro Val Val Gln Gly Pro Asp Gly Arg
  65                  70                  75                  80

 ctg gag ctg aaa cca ctg ttg ctg cga ttg ccc cgg ata tgc cag agg      288
 Leu Glu Leu Lys Pro Leu Leu Leu Arg Leu Pro Arg Ile Cys Gln Arg
                  85                  90                  95

 aac ctg atg tcc ctg ctg atg gcc gtt cgg cca tcg ctg ccg gaa agt      336
 Asn Leu Met Ser Leu Leu Met Ala Val Arg Pro Ser Leu Pro Glu Ser
             100                 105                 110

 ggg ctc ctc tct gtg ctg cag att gcc cag cag gac cta gcc cct gac      384
 Gly Leu Leu Ser Val Leu Gln Ile Ala Gln Gln Asp Leu Ala Pro Asp
         115                 120                 125

 ccc gat gcc tgg ctc cgt gcc ctg ggg gaa ttg ctg cga agg gat ttg      432
 Pro Asp Ala Trp Leu Arg Ala Leu Gly Glu Leu Leu Arg Arg Asp Leu
     130                 135                 140

 ggg gtg ggg acc tcc atg gag gga gct tct cca ctg tct gaa aga tgc      480
 Gly Val Gly Thr Ser Met Glu Gly Ala Ser Pro Leu Ser Glu Arg Cys
 145                 150                 155                 160

 cag aga cag ctc caa agt cta tgt agg ggg ctg ggc ctg ggg ggc agg      528
 Gln Arg Gln Leu Gln Ser Leu Cys Arg Gly Leu Gly Leu Gly Gly Arg
                 165                 170                 175

 agg ttg aaa tcc ccc cag gct cca gac cct gaa gaa gag gag aac agg      576
 Arg Leu Lys Ser Pro Gln Ala Pro Asp Pro Glu Glu Glu Glu Asn Arg
             180                 185                 190

 gac tcc cag cag cct ggg aaa cgc aga aag gac tca gag gaa gag gct      624
 Asp Ser Gln Gln Pro Gly Lys Arg Arg Lys Asp Ser Glu Glu Glu Ala
         195                 200                 205

 gcc agt cct gag ggg aag agg gtc ccc aaa aga tta cgg tgt tgg gaa      672
 Ala Ser Pro Glu Gly Lys Arg Val Pro Lys Arg Leu Arg Cys Trp Glu
     210                 215                 220

 gag gaa gaa gat cat gag aag gag aga ccc gaa cat aag tca ctg gaa      720
 Glu Glu Glu Asp His Glu Lys Glu Arg Pro Glu His Lys Ser Leu Glu
 225                 230                 235                 240

 tcc ctg gca gat gga gga agt gca tct cct att aag gac cag cct gtc      768
 Ser Leu Ala Asp Gly Gly Ser Ala Ser Pro Ile Lys Asp Gln Pro Val
                 245                 250                 255

 atg gca gtt aag act ggc gag gac ggt tcg aat ctg gat gat gct aaa      816
 Met Ala Val Lys Thr Gly Glu Asp Gly Ser Asn Leu Asp Asp Ala Lys
             260                 265                 270

 ggt ctg gct gag agt ttg gag ttg ccc aaa gct atc cag gac cag ctt      864
 Gly Leu Ala Glu Ser Leu Glu Leu Pro Lys Ala Ile Gln Asp Gln Leu
         275                 280                 285

 ccc agg ctg cag cag ctg ctg aag acc ttg gag gag ggg tta gag gga      912
 Pro Arg Leu Gln Gln Leu Leu Lys Thr Leu Glu Glu Gly Leu Glu Gly
     290                 295                 300

 ttg gag gat gcc ccc cca gtt gag cta cag ctt ctt cac gaa tgt agt      960
 Leu Glu Asp Ala Pro Pro Val Glu Leu Gln Leu Leu His Glu Cys Ser
 305                 310                 315                 320

 ccc agc cag atg gac ttg ctg tgt gcc cag ctg cag ctc cct cag ctc     1008
 Pro Ser Gln Met Asp Leu Leu Cys Ala Gln Leu Gln Leu Pro Gln Leu
                 325                 330                 335

 tca gac ctc ggt ctc ctg cgg ctc tgc acc tgg ctg ctg gcc ctt tca     1056
 Ser Asp Leu Gly Leu Leu Arg Leu Cys Thr Trp Leu Leu Ala Leu Ser
             340                 345                 350

 cct gat ctc agc ctc agc aat gct act gtg ctg acc aga agc ctc ttt     1104
 Pro Asp Leu Ser Leu Ser Asn Ala Thr Val Leu Thr Arg Ser Leu Phe
         355                 360                 365

 ctt gga cgg atc ctc tcc ttg act tcc tca gcc tcc cgc ctg ctt aca     1152
 Leu Gly Arg Ile Leu Ser Leu Thr Ser Ser Ala Ser Arg Leu Leu Thr
     370                 375                 380

 act gcc ctg acc tcc ttc tgt gcc aaa tat aca tac cct gtc tgc agc     1200
 Thr Ala Leu Thr Ser Phe Cys Ala Lys Tyr Thr Tyr Pro Val Cys Ser
 385                 390                 395                 400

 gcc ctc ctt gac cct gtg ctc cag gcc cca ggc aca ggt cct gct caa     1248
 Ala Leu Leu Asp Pro Val Leu Gln Ala Pro Gly Thr Gly Pro Ala Gln
                 405                 410                 415

 aca gag tta ctg tgt tgc ctt gtg aag atg gag tcc ctg gag cca gat     1296
 Thr Glu Leu Leu Cys Cys Leu Val Lys Met Glu Ser Leu Glu Pro Asp
             420                 425                 430

 gca cag gtt cta atg ctg gga cag atc ttg gag ctg ccc tgg aag gag     1344
 Ala Gln Val Leu Met Leu Gly Gln Ile Leu Glu Leu Pro Trp Lys Glu
         435                 440                 445

 gaa act ttc ttg gtg ttg cag tca ctc cta gag cgg cag gtg gag atg     1392
 Glu Thr Phe Leu Val Leu Gln Ser Leu Leu Glu Arg Gln Val Glu Met
     450                 455                 460

 acc cct gag aag ttc agt gtc tta atg gag aag ctc tgt aaa aag ggg     1440
 Thr Pro Glu Lys Phe Ser Val Leu Met Glu Lys Leu Cys Lys Lys Gly
 465                 470                 475                 480

 ctg gca gcc acc acc tcc atg gcc tat gcc aag ctc atg ctg aca gtg     1488
 Leu Ala Ala Thr Thr Ser Met Ala Tyr Ala Lys Leu Met Leu Thr Val
                 485                 490                 495

 atg acc aag tat cag gct aac atc act gag acc cag agg ctg ggc ctg     1536
 Met Thr Lys Tyr Gln Ala Asn Ile Thr Glu Thr Gln Arg Leu Gly Leu
             500                 505                 510

 gct atg gcc cta gaa cct aac acc acc ttc ctg agg aag tcc ctg aag     1584
 Ala Met Ala Leu Glu Pro Asn Thr Thr Phe Leu Arg Lys Ser Leu Lys
         515                 520                 525

 gcc gcc ttg aaa cat ttg ggc ccc tga                                 1611
 Ala Ala Leu Lys His Leu Gly Pro 
     530                 535





      <210> 326
      <211> 2131
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (969)..(1232)

      <400> 326
 gttcttctgt ctgcggtgct gtcctcgggt gtcgctccgt gcccctctgc ctcgtgctct     60

 tccgggcccg catcctgatt cctggtgtcg tctgggtgtt ttgctttgtt ccctgtgtgt    120

 cgggcctcct cctgcccgtg cggctctcgg tggctccttc ttgttgtcgt tctctcgttc    180

 tggttgcttc tgtggtgtgc tctcttgctt cttgctgtgt gttttgtctt ctgttttcgt    240

 ccgctctgtg ttgtgacccc gttgactgtc gctttttgtg cttttgctct cgtttgtgct    300

 ttggtagcct ttgctgggtg gatgtttgca cagtttgcgg ttgtcatatt ttttgccccc    360

 tatcatgtgc ccttgtttgt gtcgttgtag ttcgactgtt tacgggtttt tgaccgtttg    420

 ttttggcgca tttgtggcac tggtcgagtt gtcacactgg tgcgcgtgtg cctctttgga    480

 gttcttggtg cctggggtcc actattgtgg ccacggggtc cctgttgtcc ctgcctgtgg    540

 ccacgtgtgg gagtcgcgtt gtcggccgtg gtcgagtgtt aggcccggtg ttctcgtgag    600

 ctgtagtgcc cacgctaacc agaggtggga ggcattgcct taggcctggg ttattgagga    660

 agccatgagc gtgcgatttg gccacccaca gctccagcct gggccattcc gccaggctgt    720

 ttccaagaaa aaaaaaaaaa aaacccaaaa aaactcaaaa atgtaatgaa tgatacccaa    780

 tgtgcctttt ctagaaaaag ttgccaaata tatctcttgg atctgctgag catgtcctct    840

 gatacataag gcaagcatgt ttctacaccc agtgttgatg ccagttagtt ttcagaatcc    900

 aaactgatgg cagctactgg tccttgggac tgacatcctc tgggaatata accttctctt    960

 gggctgag atg ctg ctg cca gct cta aaa cag cac tct gtt ctc aaa acc    1010
          Met Leu Leu Pro Ala Leu Lys Gln His Ser Val Leu Lys Thr
            1               5                  10

 tca tgg cag gct cct ggc tcc aat act cag ctg cca aac atg atg ctg     1058
 Ser Trp Gln Ala Pro Gly Ser Asn Thr Gln Leu Pro Asn Met Met Leu
  15                  20                  25                  30

 att ctt cac gaa ttt gca acc cag ttc tct cgg gtt tgc aca ccc cca     1106
 Ile Leu His Glu Phe Ala Thr Gln Phe Ser Arg Val Cys Thr Pro Pro
                  35                  40                  45

 ctg tgg gcc ggg gaa ccg ggt ccc ggc ctt cgc aga ctc cag gct ctg     1154
 Leu Trp Ala Gly Glu Pro Gly Pro Gly Leu Arg Arg Leu Gln Ala Leu
              50                  55                  60

 gca gat gtg gcc ctc cat aac aac ggg aat gaa aaa cca act aaa agg     1202
 Ala Asp Val Ala Leu His Asn Asn Gly Asn Glu Lys Pro Thr Lys Arg
          65                  70                  75

 ggc tat ggt ctg ggg ggc aga agg cgc tag g agtcgtaatc ttcttcgtcc     1253
 Gly Tyr Gly Leu Gly Gly Arg Arg Arg 
      80                  85

 tcttcatcag gtgctgaggg gcccgggggc gctgggggca aaggcagagt agaggcgaag   1313

 ggcaggaagg gtgtcggggg gctctgaaag tgggcagagg ggtggctggc ctggggtggg   1373

 ggttgtgatg tctcctcttc cccatcagta tctgtgtcct cagattcatc ctcctgctcc   1433

 gagtctgtcc cggacagctt cttgtccttg cttttcgttc ccatcccacc gttcttccgg   1493

 ccgccgctgc ctggcttccg gcccctgcgg gcgcccttgt ccccatccat gtggttgtct   1553

 tccccgtccc cctgcatgtc gggaacagat gccaccaggt ccttcaagaa gtcaaactgc   1613

 tgctccagct cgatgcactg cttcaggtgg gatgtggtca tggtcttcgc gttccgcgac   1673

 tgggtcacct ggcaggcctt cttcaacagc gactctagga agagctcgag cgcccgggag   1733

 atgatgacag gcaccgccgc cgccaccttc ccaatctctt cgtccgtctg catgatcttc   1793

 ttgatccgga attccatctc cagttacagc ccgaacactg gaaactctga ttcgactggc   1853

 cacagcccat gcgaaggccc gcatgagcaa gactgtggac ctgcaggatc gaaggaagct   1913

 gtggagttgg tccagtatgc ttactttaag aaggttctgg agaaggagaa gaaacgtaag   1973

 aagcgaagtg aggatgaatc agagacagaa gatgaagagg agaaaagcca agaggaccag   2033

 gagcagaaga ggaagagaag gaagactcgc cagccagatg ccaagatggg gattcataca   2093

 cccctatgac ttcagtgaca cagaggagga agtccttc                           2131




      <210> 327
      <211> 471
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (188)..(397)

      <400> 327
 aaagtacata aatttattat gatcctgtgc tttgctcctg gatagaagag aacttgagat     60

 gatggaaaat ctcacagaag ggtgaagggt tccccagcca gccttggggt ggtgccgggt    120

 tgatgttggc cataggggtc atcaggaggg ttcagagtcc ctgggccccc atcagcacac    180

 gcatctc  atg ctg tcc aga att cta gaa ggg gac ctg tgg gcc tcc tca     229
          Met Leu Ser Arg Ile Leu Glu Gly Asp Leu Trp Ala Ser Ser
            1               5                  10

 ggg cag cgg cag ggt ggg cct cag aca ggt cac aga atg aag tgg gca      277
 Gly Gln Arg Gln Gly Gly Pro Gln Thr Gly His Arg Met Lys Trp Ala
  15                  20                  25                  30

 gtt gag tgt gtg ttt ctc tgg ccc cca aac agc cac tca gca tcc cag      325
 Val Glu Cys Val Phe Leu Trp Pro Pro Asn Ser His Ser Ala Ser Gln
                  35                  40                  45

 atc tca ggt aac acc agc ctc ttt ctc cag gcc cac cca gga agg aga      373
 Ile Ser Gly Asn Thr Ser Leu Phe Leu Gln Ala His Pro Gly Arg Arg
              50                  55                  60

 atc cag gag tca tcg ttc ccc tga tgttccatta gctgacactg cgacaaagcc     427
 Ile Gln Glu Ser Ser Phe Pro 
          65

 tgtcatccga ggtcccggct gagtcgcagt tctggtttat cagc                     471




      <210> 328
      <211> 3194
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (96)..(1016)

      <400> 328
 aaatattttg ctgcttcctc tgtagctgcc agacctgctc ttgctgctgc tcaggtagaa     60

 catctgggag gtcccttgct gaccactgga agaag   atg agc tcg agc tat tgg     113
                                          Met Ser Ser Ser Tyr Trp
                                            1               5

 agt gag acg agc agc agc agc tgt gga acc cag cag ctc cca gag gtg      161
 Ser Glu Thr Ser Ser Ser Ser Cys Gly Thr Gln Gln Leu Pro Glu Val
              10                  15                  20

 ctg cag tgc cag ccc cag cat tac cac tgc tac cat cag tca agc caa      209
 Leu Gln Cys Gln Pro Gln His Tyr His Cys Tyr His Gln Ser Ser Gln
          25                  30                  35

 gcc cag cag cct cca gaa aaa aat gta gtg tat gag cga gtg agg acc      257
 Ala Gln Gln Pro Pro Glu Lys Asn Val Val Tyr Glu Arg Val Arg Thr
      40                  45                  50

 tac agt ggg ccc atg aac aag gtg gtg cag gcc ttg gac ccc ttc aac      305
 Tyr Ser Gly Pro Met Asn Lys Val Val Gln Ala Leu Asp Pro Phe Asn
  55                  60                  65                  70

 tca cgg gaa gtg ctc tcc cct ctc aaa acc acc tcc tcc tac caa aat      353
 Ser Arg Glu Val Leu Ser Pro Leu Lys Thr Thr Ser Ser Tyr Gln Asn
                  75                  80                  85

 ttg gtt tgg agc gac cat tct cag gaa ctc cat tct cca act tta aaa      401
 Leu Val Trp Ser Asp His Ser Gln Glu Leu His Ser Pro Thr Leu Lys
              90                  95                 100

 ata tct aca tgt gcc cca agt act cta cat ata acc caa aat act gaa      449
 Ile Ser Thr Cys Ala Pro Ser Thr Leu His Ile Thr Gln Asn Thr Glu
         105                 110                 115

 cag gaa ctt cat tct cca aca gtg aaa ctt act aca tat cca cag acc      497
 Gln Glu Leu His Ser Pro Thr Val Lys Leu Thr Thr Tyr Pro Gln Thr
     120                 125                 130

 act att agg aaa tat gta gta caa aat cct gaa cag gaa cca ctg tct      545
 Thr Ile Arg Lys Tyr Val Val Gln Asn Pro Glu Gln Glu Pro Leu Ser
 135                 140                 145                 150

 caa ttc cta aga gga agc cat ttc ttc cca gga aac aat gtt att tat      593
 Gln Phe Leu Arg Gly Ser His Phe Phe Pro Gly Asn Asn Val Ile Tyr
                 155                 160                 165

 gaa aaa aca ata aga aaa gtg gag aag cta aat act gat cag ggg tgc      641
 Glu Lys Thr Ile Arg Lys Val Glu Lys Leu Asn Thr Asp Gln Gly Cys
             170                 175                 180

 cat cct cag gct caa tgc cat cat cac att atc caa cag ccc cag gtc      689
 His Pro Gln Ala Gln Cys His His His Ile Ile Gln Gln Pro Gln Val
         185                 190                 195

 atc cac tct gca cac tgg caa caa cct gat tct agc cag caa atc caa      737
 Ile His Ser Ala His Trp Gln Gln Pro Asp Ser Ser Gln Gln Ile Gln
     200                 205                 210

 gcc atc aca gga aat aat cca att tct aca cat att gga aat gaa ctg      785
 Ala Ile Thr Gly Asn Asn Pro Ile Ser Thr His Ile Gly Asn Glu Leu
 215                 220                 225                 230

 tgc cat agt gga tca agc cag att tgt gag cag gtg ata att cag gat      833
 Cys His Ser Gly Ser Ser Gln Ile Cys Glu Gln Val Ile Ile Gln Asp
                 235                 240                 245

 gat ggc cct gaa aaa ttg gac ccc aga tat ttt gga gag ttg ctt gct      881
 Asp Gly Pro Glu Lys Leu Asp Pro Arg Tyr Phe Gly Glu Leu Leu Ala
             250                 255                 260

 gat ctg agc cgt aag aat acg gat cta tat cac tgc tta tta gaa cat      929
 Asp Leu Ser Arg Lys Asn Thr Asp Leu Tyr His Cys Leu Leu Glu His
         265                 270                 275

 ttg cag aga att gga aga aaa caa tct ctc tct tcg aca tac act atc      977
 Leu Gln Arg Ile Gly Arg Lys Gln Ser Leu Ser Ser Thr Tyr Thr Ile
     280                 285                 290

 aga cat gga ata cag act aaa aga act gga ata ttg taa acgtaattta      1026
 Arg His Gly Ile Gln Thr Lys Arg Thr Gly Ile Leu 
 295                 300                 305

 gagcaagaga atcaaaacct tagaatgcag gtttctgaga cttgcacagg cccaatgttg   1086

 caggctaaaa tggatgagat tggcaaccac tacacggaga tggtaaaaaa cttgagaatg   1146

 gagaaagata gagagatctg cagactgagg tcccaattaa accagtacca taaagatgtt   1206

 tcaaagagag aaggaagttg tagtgacttc caatttaagc ttcatgaact gacaagcttg   1266

 ctggaagaga aggattccct cataaagcgt cagtcagagg aactctccaa gttgcggcaa   1326

 gaaatatatt cctctcataa ccaaccctcc actgttggaa ggactactat taccactaaa   1386

 aagtacagga cacaatatcc aatcctaggc ctcctatatg atgactacga atatatacca   1446

 ccaggtagtg aaacacagac tattgtgatt gagaaaacag aagacaaata cacttgtcca   1506

 tgaatggatc cactttaaag tattacaact caaagccgtt ttttttgtgt gtgtgtgtct   1566

 ctgcattagt actttgttat ttttccatca ctaaaggcca atcagaattt ggaaccatgc   1626

 tgctacccaa gaaatctaat ggaatgaatt agttctgtag atgacattct tcacccattt   1686

 atgagaccta aatcttttcc ataacactca tgtattcagt ataacaacat actaactgaa   1746

 agagggacct gattgtttaa agtttgattg cagacactgt agaacataac tcattatgtt   1806

 tcagataagg taactcctag atatcaaact aatttgttgg ggtagagatt ttacaagtca   1866

 tgccattata agattttctc tgatattata tgtgcagttc agttacaaga tgaaatcatt   1926

 tttttttaac aaaagagata aaatacaatt gaagcaaaaa ataacagcta gtatataata   1986

 tatacagtct gtatttgctt ttcacagtag gcctgatgac taaaagatat gctttattac   2046

 acgctatttt cacctcttga aagtcaaagg tgatgattaa tttcatttag cagggaagtg   2106

 gaataatatc ttttgaaata actaagtcca ctaaattata cagtatgcta ttctggttct   2166

 aagtacatat tagtcccttg gcaaatctgt tctttcaaag cataccttcc ccaaatgagc   2226

 ctacctactt cttaaaaaac atataacaca atgtggtagt agtaggtgta aggaaggtaa   2286

 gttttttcat agtggtatgc aaacatatca ttgaaatatt acatagatat aaagacttag   2346

 ggaataaaaa tagcagcaac aaatacttga tagatttatc ctacttggga gaaatatttt   2406

 gtagcagagt atttagtata cttagaagtt gatttagcaa ttaggcttta atgaccttac   2466

 aaagtgaaca taactgaaca caagtatttt ttcaatgcaa gatgaggatg aaaattttac   2526

 atttcaaccc atctggctaa agttaagact tagcaaaaat taaaatgttg cctttgtcca   2586

 agtatagatt aaggcaacaa acatatttgg gtgtgtaatt tgaagttttg gactgaaata   2646

 tctttgcaag tatccacata aaattctgta atgccttata attatattct aataattatg   2706

 cattatacta agacaccatt aagaacagtt gaggcactac actaaatcaa accataaatg   2766

 aggaaaaaac ttttaatgtt cttttctaga agtgttcaaa taggtcttga tatgaagcta   2826

 aaagccttat ttatattatc ttaatatttc ggctaaaatg ttaagctcca taacatgaat   2886

 tgatacaatt ccaattttat caatattttg tgatagaaaa atgttaatat tattcatgag   2946

 ctatacagtc cttacatttt ttcccttggt gtaggaacaa cggaggagtt tctcctctgc   3006

 taactattca tatatgtaac tgtaacaaaa gtgtactatg ttatgcacac attacaaata   3066

 atataagggg aagttttatt agcttagtag gaaattgtta ttattaaggt ttaaaaatga   3126

 gaacaggtgt gagttttcca aaatacttaa aaataatagt gtcaaaaatt caggggcagt   3186

 taaggagt                                                            3194




      <210> 329
      <211> 730
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(679)

      <400> 329
 cgcc atg tcg tcc gac ttc gaa ggt tac gag cag gac ttc gcg gtg ctc      49
      Met Ser Ser Asp Phe Glu Gly Tyr Glu Gln Asp Phe Ala Val Leu
        1               5                  10                  15

 act gca gag atc acc agc aag att gcg agg gtc cca cga ctc ccg cct       97
 Thr Ala Glu Ile Thr Ser Lys Ile Ala Arg Val Pro Arg Leu Pro Pro
                  20                  25                  30

 gat gaa aag aaa cag atg gtt gca aat gtg gag aaa cag ctt gaa gaa      145
 Asp Glu Lys Lys Gln Met Val Ala Asn Val Glu Lys Gln Leu Glu Glu
              35                  40                  45

 gcg aaa gaa ctg ctt gaa cag atg gat ttg gaa gtc cga gag ata cca      193
 Ala Lys Glu Leu Leu Glu Gln Met Asp Leu Glu Val Arg Glu Ile Pro
          50                  55                  60

 ccc caa agt cga ggg atg tac agc aac aga atg aga agc tac aaa caa      241
 Pro Gln Ser Arg Gly Met Tyr Ser Asn Arg Met Arg Ser Tyr Lys Gln
      65                  70                  75

 gaa atg gga aaa ctc gaa aca gat ttt aaa agg tca cgg atc gcc tac      289
 Glu Met Gly Lys Leu Glu Thr Asp Phe Lys Arg Ser Arg Ile Ala Tyr
  80                  85                  90                  95

 agt gac gaa gta cgg aat gag ctc ctg ggg gat gat ggg aat tcc tca      337
 Ser Asp Glu Val Arg Asn Glu Leu Leu Gly Asp Asp Gly Asn Ser Ser
                 100                 105                 110

 gag aac cag ttg ata aaa tta cgt gaa gag agg gca cat ctg ctc gat      385
 Glu Asn Gln Leu Ile Lys Leu Arg Glu Glu Arg Ala His Leu Leu Asp
             115                 120                 125

 aac aca gag agg ctg gaa agg tca tct cgg aga cta gag gct gga tac      433
 Asn Thr Glu Arg Leu Glu Arg Ser Ser Arg Arg Leu Glu Ala Gly Tyr
         130                 135                 140

 caa ata gca gtg gaa acc gag caa att ggt cag gag atg ttg gaa aac      481
 Gln Ile Ala Val Glu Thr Glu Gln Ile Gly Gln Glu Met Leu Glu Asn
     145                 150                 155

 ctt agt cat gac aga gaa aag ata cag cga gca cgt gaa aga ctt cgg      529
 Leu Ser His Asp Arg Glu Lys Ile Gln Arg Ala Arg Glu Arg Leu Arg
 160                 165                 170                 175

 gaa aca gat gct aat ttg gga aaa agc tcc agg att ctg aca ggg atg      577
 Glu Thr Asp Ala Asn Leu Gly Lys Ser Ser Arg Ile Leu Thr Gly Met
                 180                 185                 190

 ttg cga aga atc atc cag aac cgc atc ctg ctc gtc atc cta ggg atc      625
 Leu Arg Arg Ile Ile Gln Asn Arg Ile Leu Leu Val Ile Leu Gly Ile
             195                 200                 205

 atc gtg gtc atc acc atc ctg atg gcg atc act ttt tct gtc aga aga      673
 Ile Val Val Ile Thr Ile Leu Met Ala Ile Thr Phe Ser Val Arg Arg
         210                 215                 220

 cac tga tgtatctgct ctcccttgat aaacagcaac aacagcttgt tctgagtaat       729
 His 


 t                                                                    730




      <210> 330
      <211> 647
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (323)..(607)

      <400> 330
 ggaattcgtg taagggaggc agggcccagc tctcccacgg cgaggtgagc tgagactttc     60

 tgataacagt tagagtgggt gcgtgtctga aatgggtact cctagcagct attgtgtacg    120

 caaagcctga gtacagcctg ctggtgtcat ggccacgtgt gagcaggcca gcgtcacacg    180

 gctcgctgtg acccgtcccg gagactgaaa tgggcctggg tcttctcctt gtcctgtgat    240

 taaagtcctc tcttgaaagt ggagagcaaa ggcacacaga ggtgcgcgct cacaagaatt    300

 cctcccggtg actgggtaat ca atg tta ctg ctg ttt cct ttg cag gaa aga     352
                          Met Leu Leu Leu Phe Pro Leu Gln Glu Arg
                            1               5                  10

 cca cag caa gat tct ttc att cgt ctc ctc cta gcc tgg ggg acc agg      400
 Pro Gln Gln Asp Ser Phe Ile Arg Leu Leu Leu Ala Trp Gly Thr Arg
                  15                  20                  25

 ctc gaa ctg acc ctg gac atc aaa gga ggg att atg tgg ctg cta aag      448
 Leu Glu Leu Thr Leu Asp Ile Lys Gly Gly Ile Met Trp Leu Leu Lys
              30                  35                  40

 cca tcg gcc cac agc cct gtt cac atc ttg gtg ctt ctc ttt ccc aga      496
 Pro Ser Ala His Ser Pro Val His Ile Leu Val Leu Leu Phe Pro Arg
          45                  50                  55

 ggc tgg tcc cag cca ggc aca cac aaa agg cag att ctc gta aac gca      544
 Gly Trp Ser Gln Pro Gly Thr His Lys Arg Gln Ile Leu Val Asn Ala
      60                  65                  70

 gcc tcc ctc cct gga ggc tgc ctc ctg ccc tgg atc tgg agt gga gct      592
 Ala Ser Leu Pro Gly Gly Cys Leu Leu Pro Trp Ile Trp Ser Gly Ala
  75                  80                  85                  90

 gct ctg aga ttt tga gttcttctgc agagatgatt aaatatatcc aagagacatt      647
 Ala Leu Arg Phe 






      <210> 331
      <211> 1847
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (105)..(329)

      <400> 331
 ggcgcagcga acgagcagtg accgtgctcc tacccagctc tgcttcacag cgcccacctg     60

 tctccgcccc tcggcccctc gcccggcttt gcctaaccgc cacg atg atg ttc tcg     116
                                                  Met Met Phe Ser
                                                    1

 ggc ttc aac gca gac tac gag gcg tca tcc tcc cgc tgc agc agc gcg      164
 Gly Phe Asn Ala Asp Tyr Glu Ala Ser Ser Ser Arg Cys Ser Ser Ala
   5                  10                  15                  20

 tcc ccg gcc ggg gat agc ctc tct tac tac cac tca ccc gca gac tcc      212
 Ser Pro Ala Gly Asp Ser Leu Ser Tyr Tyr His Ser Pro Ala Asp Ser
                  25                  30                  35

 ttc tcc agc atg ggc tcg cct gtc aac gcg cag gta agg ctg gct tcc      260
 Phe Ser Ser Met Gly Ser Pro Val Asn Ala Gln Val Arg Leu Ala Ser
              40                  45                  50

 cgt cgc cgc ggg gcc ggg ggc ttg ggg tcg cgg agg agg aga cac cgg      308
 Arg Arg Arg Gly Ala Gly Gly Leu Gly Ser Arg Arg Arg Arg His Arg
          55                  60                  65

 gcg gga cgc tcc agt aga tga gt agggggctcc cttgtgcctg gagggaggct      361
 Ala Gly Arg Ser Ser Arg 
      70

 gccgtggccg gagcggtgcc ggctcggggg ctcgggactt gctctgagcg cacgcacgct    421

 tgccatagta agaattggtt cccccttcgg gaggcaggtt cgttctgagc aacctctggt    481

 ctgcactcca ggacggatct ctgacattag ctggagcaga cgtgtcccaa gcacaaactc    541

 gctaactaga gcctggcttc tccggggagg tggcagaaag cggcaatccc ccctcccccg    601

 gcagcctgga gcacggagga gggatgaggg aggagggtgc agcgggcggg tgtgtaaggc    661

 agtttcattg ataaaaagcg agttcattct ggagactccg gagcggcgcc tgcgtcagcg    721

 cacacgtcag ggatatttat aacaaacccc ctttcaagca agtgatgctg aagggataac    781

 gggaacgcag cggcaggatg gaagagacag gcactgcgct gcggaatgcc tgggaggaaa    841

 agggggagac ctttcatcca ggatgaggga catttaagat gaaatgtccg tggcaggatc    901

 gtttctcttc actgctgcat gcggcactgg gaactcgccc cacctgtgtc cggaacctgc    961

 tcgctcacgt cggctttccc cttctgtttt gttctaggac ttctgcacgg acctggccgt   1021

 ctccagtgcc aacttcattc ccacggtcac tgccatctcg accagtccgg acctgcagtg   1081

 gctggtgcag cccgccctcg tctcctctgt ggccccatcg cagaccagag cccctcaccc   1141

 tttcggagtc cccgccccct ccgctggggc ttactccagg gctggcgttg tgaagaccat   1201

 gacaggaggc cgagcgcaga gcattggcag gaggggcaag gtggaacagg tgaggaactc   1261

 tagcgtactc ttcctgggaa tgtgggggct gggtgggaag cagccccgga gatgcaggag   1321

 cccagtacag aggatgaagc cactgatggg gctggctgca catccgtaac tgggagccct   1381

 ggctccaagc ccattccatc ccaactcaga ctctgagtct caccctaaga agtactctca   1441

 tagtttcttc cctaagtttc ttaccgcatg ctttcagact gggctcttct ttgttctctt   1501

 gctgaggatc ttattttaaa tgcaagtcac acctattctg caactgcagg tcagaaatgg   1561

 tttcacagtg gggtgccagg aagcagggaa gctgcaggag ccagttctac tggggtgggt   1621

 gaatggaggt gatggcagac acttttactg aatgtcggtc tttttttgtg attattctag   1681

 ttatctccag aagaagaaaa aaaaaggaga atccgaaggg aaaggaataa gatggctgca   1741

 gccaaatgcc gcaaccggag gagggagctg actgatacac tccaagcggt aggtactctg   1801

 tgggttgctc ctttttaaaa cttaagggaa agttggagat tgagca                  1847




      <210> 332
      <211> 787
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (211)..(471)

      <400> 332
 ccctgagagg ccgtgctcgg gctcgcctgc tcagctcact ccgaaagcct ctgctcagac     60

 ctgcacccag tcacagcagc acagatgtgc aggaggagac catttccacg gaccctccga    120

 ctcctaggag gcagtccctt agggactggc cctaacaaca aatgaggaga agccaagttc    180

 tctgctttct gcagacaggg cctcccctgg     atg gga tct tcc tct gag gcg     231
                                      Met Gly Ser Ser Ser Glu Ala
                                        1               5

 agc ttc aga tct gct caa gct tcc tgc agt ggg gcc agg agg cag ggc      279
 Ser Phe Arg Ser Ala Gln Ala Ser Cys Ser Gly Ala Arg Arg Gln Gly
          10                  15                  20

 ctg ggc agg gga gac cag aac ctc tcg gtg atg cct ccg aat ggc agg      327
 Leu Gly Arg Gly Asp Gln Asn Leu Ser Val Met Pro Pro Asn Gly Arg
      25                  30                  35

 gct cag aca cac aca cct ggc tgg gtt tca gat ccc tta gtt ttg ggt      375
 Ala Gln Thr His Thr Pro Gly Trp Val Ser Asp Pro Leu Val Leu Gly
  40                  45                  50                  55

 gcc caa gtt cac gga ggg tgc cgg gga ata gaa gct ctg tca gtc tcg      423
 Ala Gln Val His Gly Gly Cys Arg Gly Ile Glu Ala Leu Ser Val Ser
                  60                  65                  70

 tct gga tct tgg tcc tca gca act gtc tgg atc ctg aca gtg cag taa      471
 Ser Gly Ser Trp Ser Ser Ala Thr Val Trp Ile Leu Thr Val Gln 
              75                  80                  85

 gagcttgcct ggcctgtgtg cagagctgcc tcatcctgaa attctgggag ttgaaagccc    531

 cagggcaacc cttaaccaat gggggaaaag cattggtgtg taaatccccc agcttccctg    591

 ggtgggctgc agctgagcca tattctacat gacacttccg aggatcccca gtgggcatga    651

 cctcaatcgc ccacattgga tgccacaacc tgcactggct tttctccctt ccctgtgggt    711

 ctctctctgc acttcctccc ttgtgcattc taggttcacc ttccaaataa atgatgtgca    771

 ctcagaaaaa aaaaaa                                                    787




      <210> 333
      <211> 1625
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (419)..(937)

      <400> 333
 aggaagtagg aaccacagca agattggttt agacttgaca gtacaaagga cttcctgggg     60

 acaaaaggtg actctgtaac atctgctctg tgaagaccct acggggctgg ggacagggtg    120

 tccaggtggg gcggtgtcca tctctgactc aaggattgtt ccagcaatcg agctgctgag    180

 gaaggaggag ccaggggctt ttgtcataag ggacagctct tcataccgag gctccttcgg    240

 cctggccctg aaggtgcagg aggttcccgc gtctgctcag aatcgaccag gtgaggacag    300

 caatgacctc atccgacact tcctcatcga gtcgtctgcc aaaggagtgc atctcaaagg    360

 agcagatgag gagccctact ttgggagcct ctctgccttc gtgtgccagc attccatc      418                                                                 
 atg gcc ctg gcc ctg ccc tgc aaa ctc acc atc cca cag aga gaa ctg      466
 Met Ala Leu Ala Leu Pro Cys Lys Leu Thr Ile Pro Gln Arg Glu Leu
   1               5                  10                  15

 gga ggt gca gat ggg gcc tcg gac tct aca gac agc cca gcc tcc tgc      514
 Gly Gly Ala Asp Gly Ala Ser Asp Ser Thr Asp Ser Pro Ala Ser Cys
              20                  25                  30

 cag aag aaa tct gcg ggc tgc cac acc ctg tac ctg agc tca gtg agc      562
 Gln Lys Lys Ser Ala Gly Cys His Thr Leu Tyr Leu Ser Ser Val Ser
          35                  40                  45

 gtg gag acc ctg act gga gcc ctg gcc gtg cag aaa gcc atc tcc acc      610
 Val Glu Thr Leu Thr Gly Ala Leu Ala Val Gln Lys Ala Ile Ser Thr
      50                  55                  60

 acc ttt gag agg gac atc ctc ccc acg ccc acc gtg gtc cac ttc aaa      658
 Thr Phe Glu Arg Asp Ile Leu Pro Thr Pro Thr Val Val His Phe Lys
  65                  70                  75                  80

 gtc aca gag cag ggc atc act ctg act gat gtc cag agg aag gtg ttt      706
 Val Thr Glu Gln Gly Ile Thr Leu Thr Asp Val Gln Arg Lys Val Phe
                  85                  90                  95

 ttc cgg cgc cat tac cca ctc acc acc ctc cgc ttc tgt ggt atg gac      754
 Phe Arg Arg His Tyr Pro Leu Thr Thr Leu Arg Phe Cys Gly Met Asp
             100                 105                 110

 cct gag caa cgg aag tgg cag aag tac tgc aaa ccc tcc tgg atc ttt      802
 Pro Glu Gln Arg Lys Trp Gln Lys Tyr Cys Lys Pro Ser Trp Ile Phe
         115                 120                 125

 ggg ttt gtg gcc aag agc cag aca gag cct cag gag aac gta tgc cac      850
 Gly Phe Val Ala Lys Ser Gln Thr Glu Pro Gln Glu Asn Val Cys His
     130                 135                 140

 ctc ttt gcg gag tat gac atg gtc cag cca gcc tcg cag gtc atc ggc      898
 Leu Phe Ala Glu Tyr Asp Met Val Gln Pro Ala Ser Gln Val Ile Gly
 145                 150                 155                 160

 ctg gtg act gct ctg ctg cag gac gca gaa agg atg tag gggagagact       947
 Leu Val Thr Ala Leu Leu Gln Asp Ala Glu Arg Met 
                 165                 170

 gcctgtgcac ctaaccaaca cctccagggg ctcgctaagg agcccccctc caccccctga   1007

 atgggtgtgg cttgtggcca tattgacaga ccaatctatg ggactagggg gattggcatc   1067

 aagttgacac ccttgaacct gctatggcct tcagcagtca ccatcatcca gaccccccgg   1127

 gcctcagttt cctcaatcat agaagaagac caatagacaa gatcagctgt tcttagatgc   1187

 tggtgggcat ttgaacatgc tcctccatga ttctgaagca tgcacacctc tgaagacccc   1247

 tgcatgaaaa taacctccaa ggaccctctg accccatcga cctgggccct gcccacacaa   1307

 cagtctgagc aagagacctg cagcccctgt ttcgtggcag acagcaggtg cctggcggtg   1367

 acccacgggg ctcctggctt gcagctggtg atggtcaaga actgactaca aaacaggaat   1427

 ggatagactc tatttccttc catatctgtt cctctgttcc ttttcccact ttctgggtgg   1487

 ctttttgggt ccacccagcc aggatgctgc aggccaagct gggtgtggta tttagggcag   1547

 ctcagcaggg ggaacttgtc cccatggtca gaggagaccc agctgtcctg cacccccttg   1607

 cagatgagta tcacccca                                                 1625




      <210> 334
      <211> 2127
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (877)..(1068)

      <400> 334
 cttggtcccg ccactcgggt cctctggctt cttcccaaac acctcctctt tctctcggtg     60

 attggccaag aggcagttcc catagtaact gacaccgcgc tcccacttcc cagcctggag    120

 gacagcaccg gccctcgtat tagcaacctg gaagagaggg cgcccaggtg ggcactcgca    180

 acttctcacg tatctgcgcg ttctcttcgc tcccactggc gtgagcctgc gctttccgcc    240

 ttccttccct cacaagcccc cttggcaacc gtcgccgttg agacggaggg agacgccccc    300

 acggattcgc cccgccgcgc ctctccgcgc gtagattggc cggagcgagg cgaacgggcc    360

 cggccttggt agccgccgac cgagcgctgg ctgtcctgga acctaggcgg cgggagcccg    420

 gggcgcctcg cggcacggaa gagcggcgag atgctcaacc gcaagaccag ccactttttg    480

 ggaatgaggg tgcagtcgga gcttgaacat ctctccgagc tgcggcggga agcggggaag    540

 gatcgcagct cagtgcatgg gtcggccgcg cggacgcgtg cgagtgtgcg gactcagtgg    600

 acgacggcgg cggcggcgaa agcggatgaa gaccccggag ccaacttgtt tccggtgagg    660

 gcgggacagt ctggtctgct cgtgaatatt tataaaccgg ctcccccgca ggcgccacct    720

 gtcattatgc ttactaacgt tcgggacgtc tcccgggctg cttgggcgag gagaggcagg    780

 ggtgtgtgac cccggtggtt actgtgctcg cgtagagcac ctagggcctg ctgaagccct    840

 ccctcgcccg cgcctctcct tagtccttga gatgag  atg gca agt tac agc ggc     894
                                          Met Ala Ser Tyr Ser Gly
                                            1               5

 ttc tcc ggc ctg ctg gag att cgc tac ggg cca gga cac cgc agc tgc      942
 Phe Ser Gly Leu Leu Glu Ile Arg Tyr Gly Pro Gly His Arg Ser Cys
              10                  15                  20

 ctt ccc caa ttc gct ttc ttt ccg cag ccg ccg ctg ccc cga ccc cgg      990
 Leu Pro Gln Phe Ala Phe Phe Pro Gln Pro Pro Leu Pro Arg Pro Arg
          25                  30                  35

 atc tgc atg tgg aag tac ctg gac gtc cat tcc atg cac cag ctg gag     1038
 Ile Cys Met Trp Lys Tyr Leu Asp Val His Ser Met His Gln Leu Glu
      40                  45                  50

 aag acc acc aat gct gag atg agg gag tag g gactgagggg ggcgtgggaa     1089
 Lys Thr Thr Asn Ala Glu Met Arg Glu 
  55                  60

 gagctcttgg caaaggctga ggggtcaggt tgggaaaaca tgaggaatgg ctgactccaa   1149

 agcatgtggt gggtgtaggg tgatgaaagg aggcccagtt gtcactcact cctctctccc   1209

 tcccaagggt gctggctgag ctgctggagc tagggtgtcc tgagcagagc ctgagggacg   1269

 ccatcaccct ggacctcttc tgccacgcgc tcattttctg ccgccagcag ggcttctcac   1329

 tggagcagac gtcagcggct tgtgccctgc tccaggatct tcacaaggct tgtattgctc   1389

 atggtcataa acagctgttg agtgaagtga atgaatggat accagagagg gcctcactgc   1449

 tgcatcttgc tttccctacc agcaaccccc ttgggcaacg tggaggagtg ctaccgctac   1509

 ttcaccagtg tccttttttg ccatggagtc aggcggcctc ctttcagcat cgacctcttc   1569

 aaagaggaac agctgctggc cttggaagac tacgtggtca acacttactt ccgccacttc   1629

 aagctctata aatacgtctt cacaccccag gtgcggctgg atctgtcttt gacttacatg   1689

 gggctacagc cacccaaact gtggccagag agtgagacgg gtaagggaga gtgccagggc   1749

 agggctgggc tgggccaggc ctggggccac agtctcttcc tgcttctggt ttgcagagaa   1809

 agaagaaagc aaggagatgg aggagcaggc agttaccccg cagaaagagg aactagagac   1869

 agtggcccca ccagagccag agccaagcca catccacgtc ctccgagcct acatcaagac   1929

 ccaagtgaac aaagagctgg agcagctcca ggggctggtg gaggagcggc tcaaggccag   1989

 cgaggaaagg ctcagcagca agttgactgc actagagcgg cccttccagc tacctccggg   2049

 taaaggcaag agcaagacca agtgaccccc aacattttcc ccaataaagg tctgggccag   2109

 aatggcaaaa aaaaaaaa                                                 2127




      <210> 335
      <211> 845
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (289)..(525)

      <400> 335
 catcttgaat tagaattaat acatgaattt aatgaatgtc ctcatctatc ttaactctgc     60

 aaactggaat gtggcgctca cgtaaaactt tttctctgtt ttctctctta ggattttctt    120

 atgtcacagc cattactcat gttttcgttc ttttggctgg gattatcatg ggactcctct    180

 ggcagaagtt ggttctggga agatggctct gttccctctc catccttgta cgtctctaac    240

 tattgagggt aaacacaagc tttccatgga atcctgggaa aattaata atg att gtg     297
                                                      Met Ile Val
                                                        1

 aga att ata aat aca gac ata aaa aga gga gta caa cat act gag aaa      345
 Arg Ile Ile Asn Thr Asp Ile Lys Arg Gly Val Gln His Thr Glu Lys
       5                  10                  15

 aga gct cca gta aca aat att gaa agg aga ttt agt act aaa gaa ctt      393
 Arg Ala Pro Val Thr Asn Ile Glu Arg Arg Phe Ser Thr Lys Glu Leu
  20                  25                  30                  35

 gac cag atc aat gga tcc aaa gga tgt gct tat ttt caa aaa gga aat      441
 Asp Gln Ile Asn Gly Ser Lys Gly Cys Ala Tyr Phe Gln Lys Gly Asn
                  40                  45                  50

 att tat att tct cgc tgt agt gct gaa att ttt tgg att tgc gag aag      489
 Ile Tyr Ile Ser Arg Cys Ser Ala Glu Ile Phe Trp Ile Cys Glu Lys
              55                  60                  65

 aca gct gcc cca gtg aag act gag gat ttg gat tag tatg cttcttccaa      539
 Thr Ala Ala Pro Val Lys Thr Glu Asp Leu Asp 
          70                  75

 attctccaag aagtaagaga cttgtgagta agctcatatg aggaaagagg aaactacggt    599

 accagagcca aaccagcttt taaaatgact gtgtatttac attatcagac aaatgaactt    659

 gtttaacaga acattctcca gttccttgtc tgacgtcttc tgatttgatg ttattattcg    719

 gtcttaaaat tatacctggg gacaaagggg aatagccata ctatggccct atgattgtct    779

 cagaatcatt tcactgaatt tctttgcttt ctcaaataaa gactcctttc tttcaaaaaa    839

 aaaaaa                                                               845




      <210> 336
      <211> 927
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (366)..(746)

      <400> 336
 gatccccaga atggttgctg ctgataatca ggacaccagt aatttacctc agttagctgt     60

 accagcacct cgagtttctc atcgaatgca gcccagaggt tctttttact ccatggtacc    120

 aaatgcaact attcaccagg atccccagtc tatttttgtt acgaatccag ttactttaac    180

 accacctcaa ggcccaccag ctgcagtgca gctttcttca gctgtgaaca ttatgaatgg    240

 ttctcagatg cacataaacc cagcaaataa gtctttgcca cctacatttg gcccagccac    300

 acttttcaat cacttcagca gtctttttga tagtagtcag gtgccagcta accagggctg    360

 gggag    atg gtc cac tgt cct cac gag ttg cta cag atg cct ctt tca     407
          Met Val His Cys Pro His Glu Leu Leu Gln Met Pro Leu Ser
            1               5                  10

 ctg ttc agt cag cgt tcc tgg gta act cag tgc ttg gac act tgg aaa      455
 Leu Phe Ser Gln Arg Ser Trp Val Thr Gln Cys Leu Asp Thr Trp Lys
  15                  20                  25                  30

 aca tgc acc ctg ata act caa agg cac ctg gct tca gac cac ctt ccc      503
 Thr Cys Thr Leu Ile Thr Gln Arg His Leu Ala Ser Asp His Leu Pro
                  35                  40                  45

 agc gag ttt cta cta gtc cag ttg ggt tac cat cca ttg acc cat cag      551
 Ser Glu Phe Leu Leu Val Gln Leu Gly Tyr His Pro Leu Thr His Gln
              50                  55                  60

 gca gct ccc cat ctt cct ctt ctg ctc ctc tgg caa gtt ttt ccg gca      599
 Ala Ala Pro His Leu Pro Leu Leu Leu Leu Trp Gln Val Phe Pro Ala
          65                  70                  75

 tac cag gaa caa ggg ttt tcc tgc aag ggc cag ctc ctg ttg gga ctc      647
 Tyr Gln Glu Gln Gly Phe Ser Cys Lys Gly Gln Leu Leu Leu Gly Leu
      80                  85                  90

 cta gtt tca aca gac aac att ttt ctc ccc atc ctt gga caa gcg cct      695
 Leu Val Ser Thr Asp Asn Ile Phe Leu Pro Ile Leu Gly Gln Ala Pro
  95                 100                 105                 110

 caa act cat gta gga atc ctg gag gaa ctc ttc cca aag agt ttt gaa      743
 Gln Thr His Val Gly Ile Leu Glu Glu Leu Phe Pro Lys Ser Phe Glu
                 115                 120                 125

 taa gtta ttaaatcatt tatttcagtt acaacaccat gttgtaactt tagtaaacta      800
 


 agtggtatac agatgcccaa ggtttgttct gtggtcatgt gaaaaaattg tcagtcattt    860

 ttagcataga aaacttgaga attattcttt caagccaaaa atgttttaca gtagaacttg    920

 gatcaag                                                              927




      <210> 337
      <211> 2650
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (337)..(1122)

      <400> 337
 cgcctagccg cgccggtccc agaagtggcg aaagccgcag ccgagtccag gtcacgccga     60

 agccgttgcc cttttaaggg ggagccttga aacggcgcct gggttccatg tttgcatccg    120

 cctcgcggga aggaaactcc atgttgtaac aaagtttcct ccgcgccccc tccctccccc    180

 tcccccctag aacctggctc ccctcccctc cggagctcgc ggggatccct ccctcccacc    240

 cctcccctcc cccccgcgcc ccgattccgg ccccagccgg gggggaggcc gggcgcccgg    300

 gccagagtcc ggccggagcg gagcgcgccc ggcccc  atg gac agc tcg gcc gtc     354
                                          Met Asp Ser Ser Ala Val
                                            1               5

 att act cag atc agc aag gag gag gct cgg ggc ccg ctg cgg ggc aaa      402
 Ile Thr Gln Ile Ser Lys Glu Glu Ala Arg Gly Pro Leu Arg Gly Lys
              10                  15                  20

 ggt gac cag aag tca gca gct tcc cag aag ccc cga agc cgg ggc atc      450
 Gly Asp Gln Lys Ser Ala Ala Ser Gln Lys Pro Arg Ser Arg Gly Ile
          25                  30                  35

 ctc cac tca ctc ttc tgc tgt gtc tgc cgg gat gat ggg gag gcc ctg      498
 Leu His Ser Leu Phe Cys Cys Val Cys Arg Asp Asp Gly Glu Ala Leu
      40                  45                  50

 cct gct cac agc ggg gcg ccc ctg ctt gtg gag gag aat ggc gcc atc      546
 Pro Ala His Ser Gly Ala Pro Leu Leu Val Glu Glu Asn Gly Ala Ile
  55                  60                  65                  70

 cct aag cag acc cca gtc caa tac ccg ctc cct gag gcc aag gcc cag      594
 Pro Lys Gln Thr Pro Val Gln Tyr Pro Leu Pro Glu Ala Lys Ala Gln
                  75                  80                  85

 gac tca gac aag atc tgc gtg gtc atc gac ctg gac gag acc ctg gtg      642
 Asp Ser Asp Lys Ile Cys Val Val Ile Asp Leu Asp Glu Thr Leu Val
              90                  95                 100

 cac agc tcc ttc aag cca gtg aac aac gcg gac ttc atc atc cct gtg      690
 His Ser Ser Phe Lys Pro Val Asn Asn Ala Asp Phe Ile Ile Pro Val
         105                 110                 115

 gag att gat ggg gtg gtc cac cag gtc tac gtg ttg aag cgt cct cac      738
 Glu Ile Asp Gly Val Val His Gln Val Tyr Val Leu Lys Arg Pro His
     120                 125                 130

 gtg gat gag ttc ctg cag cga atg ggc gag ctc ttt gaa tgt gtg ctg      786
 Val Asp Glu Phe Leu Gln Arg Met Gly Glu Leu Phe Glu Cys Val Leu
 135                 140                 145                 150

 ttc act gct agc ctc gcc aag tac gca gac cca gta gct gac ctg ctg      834
 Phe Thr Ala Ser Leu Ala Lys Tyr Ala Asp Pro Val Ala Asp Leu Leu
                 155                 160                 165

 gac aaa tgg ggg gcc ttc cgg gcc cgg ctg ttt cga gag tcc tgc gtc      882
 Asp Lys Trp Gly Ala Phe Arg Ala Arg Leu Phe Arg Glu Ser Cys Val
             170                 175                 180

 ttc cac cgg ggg aac tac gtg aag gac ctg agc cgg ttg ggt cga gac      930
 Phe His Arg Gly Asn Tyr Val Lys Asp Leu Ser Arg Leu Gly Arg Asp
         185                 190                 195

 ctg cgg cgg gtg ctc atc ctg gac aat tca cct gcc tcc tat gtc ttc      978
 Leu Arg Arg Val Leu Ile Leu Asp Asn Ser Pro Ala Ser Tyr Val Phe
     200                 205                 210

 cat cca gac aat gct gta ccg gtg gcc tcg tgg ttt gac aac atg agt     1026
 His Pro Asp Asn Ala Val Pro Val Ala Ser Trp Phe Asp Asn Met Ser
 215                 220                 225                 230

 gac aca gag ctc cac gac ctc ctc ccc ttc ttc gag caa ctc agc cgt     1074
 Asp Thr Glu Leu His Asp Leu Leu Pro Phe Phe Glu Gln Leu Ser Arg
                 235                 240                 245

 gtg gac gac gtg tac tca gtg ctc agg cag cca cgg cca ggg agc tag     1122
 Val Asp Asp Val Tyr Ser Val Leu Arg Gln Pro Arg Pro Gly Ser 
             250                 255                 260

 tgagggtgat ggggccagga cctgcccctg accaatgata cccacacctc ctcccaggaa   1182

 gactgcccag gcctttgtta ggaaaaccca tgggccgccg ccacactcag tgccatgggg   1242

 aagcgggcgt ctcccccacc agccccacca ggcggtgtag gggcagcagg ctgcactgag   1302

 gaccgtgagc tccaggcccc gtgtcagtgc cttcaaacct cctcccctat tctcagggga   1362

 cctggggggc cctgcctgct gctccctttt tctgtctctg tccatgctgc catgtttctc   1422

 tgctgccaaa ttgggcccct tggccccttc cggttctgct tcctgggggc agggttcctg   1482

 ccttggaccc ccagtctggg aacggtggac atcaagtgcc ttgcatagag ccccctcttc   1542

 cccgcccagc tttcccaggg gcacagctct aggctgggag gggagaacca gcccctcccc   1602

 ctgccccacc tcctcccttg ggactgagag ggcccctacc aacctttgcc tctgccttgg   1662

 agggagggga ggtctgttac cactggggaa ggcagcagga gtctgtcctt caggccccac   1722

 agtgcagctt ctccagggcc gacagctgag ggctgctccc tgcatcatcc aagcaatgac   1782

 ctcagacttc tgccttaacc agccccgggg cttggctccc ccagctctga gcgtgggggc   1842

 ataggcagga ccccccttgt ggtgccatat aaatatgtac atgtgtatat agatttttag   1902

 gggaaggaga gagggaaggg tcagggtaga gacacccctc ccttgcccct ttcctgggcc   1962

 cagaagttgg ggggagggag ggaaaggatt tttacatttt ttaaactgct attttctgaa   2022

 tggaacaagc tgggccaagg ggcccaggcc ctgtcctctg tccctcacac ccctttgctc   2082

 cgttcattca ttcaaaaaaa catttcttga gcaccttctg tgcccagcat atgctaggcc   2142

 caccagctaa gtgtgtgtgg ggggtctcta cgccagctca tcagtgcctc cttgcccatc   2202

 cttcaccggt gcctttgggg gatctgtagg aggtgggacc ttctgtgggg tttggggatc   2262

 tccaggaagc ccgaccaagc tgtccccttc ccctgtgcca acccatctcc tacagccccc   2322

 tgcctgatcc cctgctggct gggggcagct cccaggatat cctgccttcc aactgtttct   2382

 gaagcccctc ctcctaacat ggcgattccg gaggtcaagg ccttgggctc tccccagggt   2442

 ctaacggtta aggggaccca cataccagtg ccaaggggga tgtcaagtgg tgatgtcgtt   2502

 gtgctcccct cccccagagc gggtgggcgg ggggtgaata tggttggcct gcatcaggtg   2562

 gccttcccat ttaagtgcct tctctgtgac tgagagccct agtgtgatga gaactaaaga   2622

 gaaagccaga cccctaaaaa aaaaaaaa                                      2650




      <210> 338
      <211> 966
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (271)..(600)

      <400> 338
 tttcgtttgg aaaactgtct ttgttgctct gggagagggg actcctggaa tgtgtctgtg     60

 aataaagact agccgaaggt gcgaagtgac tagacgggag caaaggagga aaactaggga    120

 atgggaggtg agagtggctg acaccgaccc aacgtccggg ttgccggaag gctgcagcgc    180

 ccggagcggt gtcgggcaaa ccgctaccct ggtattgctg gagcctctcc tggggacttt    240

 tgaacagata ctgtggcctc atgaatagga     atg tct gcc cat atg tca gga     291
                                      Met Ser Ala His Met Ser Gly
                                        1               5

 ttg gaa ata atg gat gaa gat caa tta atc aaa gac gtc ttg gat aaa      339
 Leu Glu Ile Met Asp Glu Asp Gln Leu Ile Lys Asp Val Leu Asp Lys
          10                  15                  20

 ttc ctt aat tgt cat gag caa aca tat gat gaa gaa ttt ctg aac act      387
 Phe Leu Asn Cys His Glu Gln Thr Tyr Asp Glu Glu Phe Leu Asn Thr
      25                  30                  35

 ttt act cat ctt tca caa gag gat cat gtg tcc aaa agg gga gtg ttt      435
 Phe Thr His Leu Ser Gln Glu Asp His Val Ser Lys Arg Gly Val Phe
  40                  45                  50                  55

 gga act gat tct tca gaa aac att ttt acc tca gca aaa gtt act cat      483
 Gly Thr Asp Ser Ser Glu Asn Ile Phe Thr Ser Ala Lys Val Thr His
                  60                  65                  70

 aaa aat gaa gca gat gac tac cat ctt aga aat aaa acc atc ttt ctt      531
 Lys Asn Glu Ala Asp Asp Tyr His Leu Arg Asn Lys Thr Ile Phe Leu
              75                  80                  85

 cgt act tca tca caa tgt ttg gaa gaa cag att tgc tgc tgc ttc cag      579
 Arg Thr Ser Ser Gln Cys Leu Glu Glu Gln Ile Cys Cys Cys Phe Gln
          90                  95                 100

 gag aag tgg agc agg atg taa gc accagcattc cttcctgtat cccttttgtg      632
 Glu Lys Trp Ser Arg Met 
     105

 gcccagcctc ctacctgtga agtgaagcca aagcccagtg ttaaaagaat ggacaaacag    692

 acggaagaga tacttggaga tgaagttcaa cttttttcac ttgatgaaga atttgattat    752

 gacaatgtga tgctaacctc caagtttagt cctgcagaga tagagaacat caaagagcta    812

 tgcaagcagc agaagagaaa ggacaccagc ccagacttag agaaatcctg tgactgattc    872

 acagaggcat tttgtgtgtg tgtgcttatt ttaattttgt tcttattcta gcaacattag    932

 aataaaagat aaacctacta taaaaaaaaa aaaa                                966




      <210> 339
      <211> 743
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (72)..(431)

      <400> 339
 gagctgtcag aaggaacaat agcactaggt aaggaaatga ttaagcccat ttcctctttg     60

 cccttcccaa a atg ctt aaa cat ctg aag gga ttc tta ggc att att gaa     110
              Met Leu Lys His Leu Lys Gly Phe Leu Gly Ile Ile Glu
                1               5                  10

 ttt tgc aaa cta gga ata ccc agg tac agt gag ata act cgc cct tta      158
 Phe Cys Lys Leu Gly Ile Pro Arg Tyr Ser Glu Ile Thr Arg Pro Leu
      15                  20                  25

 tac cac ctc ata aaa gaa atg caa gca gct aaa act cag tcc ctg act      206
 Tyr His Leu Ile Lys Glu Met Gln Ala Ala Lys Thr Gln Ser Leu Thr
  30                  35                  40                  45

 tgg gaa cct ggg gct caa aaa ggc ttt aac cag tta aaa caa gcc ttg      254
 Trp Glu Pro Gly Ala Gln Lys Gly Phe Asn Gln Leu Lys Gln Ala Leu
                  50                  55                  60

 ctt aaa gca cca gcc ctt agt ctt ccc ata gga aag aca ttc agt ctc      302
 Leu Lys Ala Pro Ala Leu Ser Leu Pro Ile Gly Lys Thr Phe Ser Leu
              65                  70                  75

 tat gta gca aaa agg aag aga atg gcc ctg gga gtt tta act cag gct      350
 Tyr Val Ala Lys Arg Lys Arg Met Ala Leu Gly Val Leu Thr Gln Ala
          80                  85                  90

 caa ggt cca gct caa cag cca gta ggt tac cta agc aag gag ctt gag      398
 Gln Gly Pro Ala Gln Gln Pro Val Gly Tyr Leu Ser Lys Glu Leu Glu
      95                 100                 105

 ttg atg gct aaa gta cgg cca gct tgc ctc tga gcagttac agcagtggct      449
 Leu Met Ala Lys Val Arg Pro Ala Cys Leu 
 110                 115

 ttactggtgt cagtggccca ccaagttaac catgaggaac gacttaactg tatataaccc    509

 acataatgcg gcagaactgc tgtcttctaa gagaagtccc tggccaacag ataatcacct    569

 cctcaaagat tcaggctctg ctgttagagg aatctacagt ccagttaaaa aaacctgtcc    629

 ttgcctgaac ccagacactt tcctcccaga ggaaactgaa gaacctgaat atggctttga    689

 acagtcatgc aaacctatgc agccaaggag gacctcaaag aaactcccct agaa          743




      <210> 340
      <211> 2810
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (437)..(1861)

      <220>
      <221> misc_feature
      <222> (1)...(2810)
      <223> n = a,t,c or g

      <400> 340
 ctcggtgcaa atatccatgt cttacctaat taagcaacat catagtgcca taactcaagg     60

 aagttgaatg aggtgaacat agatacagct ctttcccctt cccccccttt ttaaatgtaa    120

 caaatacttt ttatgttccc cttcccccct tccccttttc ccctttcccc ttttggaaac    180

 gtgtcaggaa ccaaatagtt taagatgagc agttgagggg actgagagag tgatcgacac    240

 agaacctggc ttcttcgtgc ttcatcataa gtcgtgctgc cggccaggtt acttaagcac    300

 ccttttaaca aggaaacctt gtgggagatc cagctggccg actcgagttc agaaacagga    360

 ccacagaggt tacactctgg gatcctggcc atgaggttgg atgcctcacc ttactgaaag    420

 gagacactgg acctaa    atg gcg cag cat gat ttt gtt cct gct tgg cta     469
                      Met Ala Gln His Asp Phe Val Pro Ala Trp Leu
                        1               5                  10

 aat ttc tca aca cca cag tca gct aag tca cct act gcc acc ttc gaa      517
 Asn Phe Ser Thr Pro Gln Ser Ala Lys Ser Pro Thr Ala Thr Phe Glu
              15                  20                  25

 aaa cac gga gag cac cta ccc aga gga gaa ggt aga ttt gga gta agc      565
 Lys His Gly Glu His Leu Pro Arg Gly Glu Gly Arg Phe Gly Val Ser
          30                  35                  40

 cgc cgt cga cat aat tcc tct gat ggt ttt ttt aac aat ggt ccc cta      613
 Arg Arg Arg His Asn Ser Ser Asp Gly Phe Phe Asn Asn Gly Pro Leu
      45                  50                  55

 cga act gca gga gat tct tgg cac cag ccc tcc ctg ttc cgc cat gat      661
 Arg Thr Ala Gly Asp Ser Trp His Gln Pro Ser Leu Phe Arg His Asp
  60                  65                  70                  75

 tct gtg gac tct ggt gtc tct aag gga gca tat gct gga atc aca ggg      709
 Ser Val Asp Ser Gly Val Ser Lys Gly Ala Tyr Ala Gly Ile Thr Gly
                  80                  85                  90

 aac cca tct ggt tgg cat agc tct tcc cga ggt cat gat ggc atg agc      757
 Asn Pro Ser Gly Trp His Ser Ser Ser Arg Gly His Asp Gly Met Ser
              95                 100                 105

 caa cgt agt gga ggt ggc aca ggg aac cat cgc cat tgg aat ggc agc      805
 Gln Arg Ser Gly Gly Gly Thr Gly Asn His Arg His Trp Asn Gly Ser
         110                 115                 120

 ttc cac tcc cgg aaa ggg tgt gct ttt cag gaa aag cca cct atg gag      853
 Phe His Ser Arg Lys Gly Cys Ala Phe Gln Glu Lys Pro Pro Met Glu
     125                 130                 135

 att agg gaa gaa aag aaa gaa gac aag gtg gaa aag ttg cag ttt gaa      901
 Ile Arg Glu Glu Lys Lys Glu Asp Lys Val Glu Lys Leu Gln Phe Glu
 140                 145                 150                 155

 gag gag gac ttt cct tcc ttg aat cca gaa gct ggc aaa cag cat cag      949
 Glu Glu Asp Phe Pro Ser Leu Asn Pro Glu Ala Gly Lys Gln His Gln
                 160                 165                 170

 cca tgc aga cct att ggg aca cct tct gga gta tgg gaa aac ccg cct      997
 Pro Cys Arg Pro Ile Gly Thr Pro Ser Gly Val Trp Glu Asn Pro Pro
             175                 180                 185

 agt gcc aag caa ccc tcc aag atg cta gtt atc aaa aaa gtt tcc aaa     1045
 Ser Ala Lys Gln Pro Ser Lys Met Leu Val Ile Lys Lys Val Ser Lys
         190                 195                 200

 gag gat cct gct gct gcc ttc tct gct gca ttc acc tca cca gga tct     1093
 Glu Asp Pro Ala Ala Ala Phe Ser Ala Ala Phe Thr Ser Pro Gly Ser
     205                 210                 215

 cac cat gca aat ggg aac aaa ttg tca tcc gtg gtt cca agt gtc tat     1141
 His His Ala Asn Gly Asn Lys Leu Ser Ser Val Val Pro Ser Val Tyr
 220                 225                 230                 235

 aag aac ctg gtt cct aag cct gta cca cct cct tcc aag cct aat gca     1189
 Lys Asn Leu Val Pro Lys Pro Val Pro Pro Pro Ser Lys Pro Asn Ala
                 240                 245                 250

 tgg aaa gct aac agg atg gag cac aag tca gga tcc ctt tcc tct agc     1237
 Trp Lys Ala Asn Arg Met Glu His Lys Ser Gly Ser Leu Ser Ser Ser
             255                 260                 265

 cgg gag tct gct ttt acc agt cca atc tct gtt acc aaa cca gtg gta     1285
 Arg Glu Ser Ala Phe Thr Ser Pro Ile Ser Val Thr Lys Pro Val Val
         270                 275                 280

 ctg gct agt ggt gca gct ctg agt tct ccc aaa gag agt ccc tcc agc     1333
 Leu Ala Ser Gly Ala Ala Leu Ser Ser Pro Lys Glu Ser Pro Ser Ser
     285                 290                 295

 acc acc cct cca att gag atc agc tcc tct cgt ctg acc aag ttg acc     1381
 Thr Thr Pro Pro Ile Glu Ile Ser Ser Ser Arg Leu Thr Lys Leu Thr
 300                 305                 310                 315

 cgc cga acc acc gac agg aag agt gag ttc ctg aaa act ctg aag gat     1429
 Arg Arg Thr Thr Asp Arg Lys Ser Glu Phe Leu Lys Thr Leu Lys Asp
                 320                 325                 330

 gac cgg aat gga gac ttc tca gag aat aga gac tgt gac aag ctg gaa     1477
 Asp Arg Asn Gly Asp Phe Ser Glu Asn Arg Asp Cys Asp Lys Leu Glu
             335                 340                 345

 gat ttg gag gac aac agc aca cct gaa cca aag gaa aat ggg gag gaa     1525
 Asp Leu Glu Asp Asn Ser Thr Pro Glu Pro Lys Glu Asn Gly Glu Glu
         350                 355                 360

 ggc tgt cat caa aat ggt ctt gcc ctc cct gta gtg gaa gaa ggg gag     1573
 Gly Cys His Gln Asn Gly Leu Ala Leu Pro Val Val Glu Glu Gly Glu
     365                 370                 375

 gtt ctc tca cac tct cta gaa gca gag cac agg tta ttg aaa gct atg     1621
 Val Leu Ser His Ser Leu Glu Ala Glu His Arg Leu Leu Lys Ala Met
 380                 385                 390                 395

 ggt tgg cag gaa tat cct gaa aat gat gag aat tgc ctt ccc ctc aca     1669
 Gly Trp Gln Glu Tyr Pro Glu Asn Asp Glu Asn Cys Leu Pro Leu Thr
                 400                 405                 410

 gag gat gag ctc aaa gag ttc cac atg aag aca gag cag ctg aga aga     1717
 Glu Asp Glu Leu Lys Glu Phe His Met Lys Thr Glu Gln Leu Arg Arg
             415                 420                 425

 aat ggc ttt gga aag aat ggc ttc ttg cag agc cgc agt tcc agt ctg     1765
 Asn Gly Phe Gly Lys Asn Gly Phe Leu Gln Ser Arg Ser Ser Ser Leu
         430                 435                 440

 ttc tcc cct tgg aga agc act tgc aaa gca gag ttt gag gac tca gac     1813
 Phe Ser Pro Trp Arg Ser Thr Cys Lys Ala Glu Phe Glu Asp Ser Asp
     445                 450                 455

 acc gaa acc agt agc agt gaa aca tca gat gac gat gcc tgg aag tag     1861
 Thr Glu Thr Ser Ser Ser Glu Thr Ser Asp Asp Asp Ala Trp Lys 
 460                 465                 470

 gcatataaat gctcacagtt aaatctgacc cagtaaactc tgtgtgttta gggagtatac   1921

 aaaagaaatc gttcttttcc ttttcttatg ttgttgaata cttcattcac aagggaaata   1981

 atcatatccc aaagagagag caattggctt gttttgcttt tgttattgtt cttccctgtt   2041

 atctgcttta tagagagaag tttgtgtggt gggacagatt ttttaaacac actcacacac   2101

 acacacacat acacacccag tatatatggg gcgatgcaca ggtaggagct ggcagtgcag   2161

 ggaagaggag acactggtct gcagcaacag cttctactac cagcccttgg ggcactcacc   2221

 cctgtgatca agcaatcatt gtcaatgaca aagtgactat tgaagttata attgtattaa   2281

 attaatgcta ataatttgga tattttattt tatttttggc tgctcgggta actttagccc   2341

 ttaaccaagc atatgtgggt ttttttggtt gttttttttt gttttttttt tctttttcct   2401

 ttttgggtac agctgtaaaa tatttggata taggaaatgt tgtgttattc ttgcagcctt   2461

 gatattcagg gtggattgta aaatataaat ttttgtgaga tttcaaagat taagattatt   2521

 ttgataacat tatttacaga tttaaaagat gtggttatca caagtctcga gggggaaact   2581

 actgcataaa ataactaact tggaataaat attttgcatc agtttggatt gtcttgtgta   2641

 agaagtatat tttctttana attagatgag tggattcttt tttaggggaa atatttttag   2701

 aagttggggg gaaatgtgaa ttcagacaca actgtttctc tattttagca gatacttttt   2761

 tgatgcagaa aaacctgtgc aataaattac cagtaataaa aaaaaaaaa               2810




      <210> 341
      <211> 1961
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (363)..(1067)

      <400> 341
 ggagatgacc aggacagtta agagttgaaa ttgctgaaga gatccaggta caagggcaag     60

 gaaataagaa tgacggtgga gttgaggatg ttgcagaact ccaggatata ggaagccaga    120

 gaaagtgcac agatgaggat gttggagagc ctcgagcacc aaggggagga aacaaggatc    180

 tggtcagagg agaggatgct gtgagggaca gtctccaagt cgactgttct gggagtgaga    240

 ggcccacagg caggaagcac agcctaccat ggcctccagc cttcactggc tatggatgtg    300

 ggacccggga acaggaacag gcagtggctg tgaatggttt catctctgcc ccctgtcctg    360

 ag   atg aat cct gtc ccc cac tgg ggt gaa gtc ttc ctg ctg gtg ggt     407
      Met Asn Pro Val Pro His Trp Gly Glu Val Phe Leu Leu Val Gly
        1               5                  10                  15

 ggg gag gga gag cat ctg gcc agc cag ggc aca acc cct gcc agg gat      455
 Gly Glu Gly Glu His Leu Ala Ser Gln Gly Thr Thr Pro Ala Arg Asp
                  20                  25                  30

 cat aga gtg ggg atc agt cca gcc tcc cag cag gcc caa cct gaa tcc      503
 His Arg Val Gly Ile Ser Pro Ala Ser Gln Gln Ala Gln Pro Glu Ser
              35                  40                  45

 tgg aga aga cga caa agg gac aaa ggg gtg gat cca gag aag gcc ccc      551
 Trp Arg Arg Arg Gln Arg Asp Lys Gly Val Asp Pro Glu Lys Ala Pro
          50                  55                  60

 agc ctg act cgg cag tcc caa aac cct ccg tct ctg aca gct ccc ttg      599
 Ser Leu Thr Arg Gln Ser Gln Asn Pro Pro Ser Leu Thr Ala Pro Leu
      65                  70                  75

 ggc atg ccc tct gcc tgc tcc tgt ctc ccg tgt ggc cca gcc ccg gaa      647
 Gly Met Pro Ser Ala Cys Ser Cys Leu Pro Cys Gly Pro Ala Pro Glu
  80                  85                  90                  95

 gct gcc atc att cta gcg ggt cct ccc acc gcc ctc act gtc ctg ccc      695
 Ala Ala Ile Ile Leu Ala Gly Pro Pro Thr Ala Leu Thr Val Leu Pro
                 100                 105                 110

 aag ggg aca ggc ctc aag aag agc aaa cga ctg ctc ctg gag tcc ctc      743
 Lys Gly Thr Gly Leu Lys Lys Ser Lys Arg Leu Leu Leu Glu Ser Leu
             115                 120                 125

 atg cgg agg agg att gca cac ctg aag tgg ggt ctt ccc cgg cgg atc      791
 Met Arg Arg Arg Ile Ala His Leu Lys Trp Gly Leu Pro Arg Arg Ile
         130                 135                 140

 ctg gag tcc tat ttc ctg ttt aac ttc tta gga tct tgc tca ttg acc      839
 Leu Glu Ser Tyr Phe Leu Phe Asn Phe Leu Gly Ser Cys Ser Leu Thr
     145                 150                 155

 ctt gct ggg gcg agg ctc tct gga ctg aac aca ggc cag gag ctc caa      887
 Leu Ala Gly Ala Arg Leu Ser Gly Leu Asn Thr Gly Gln Glu Leu Gln
 160                 165                 170                 175

 gcc cag cag gaa agg tat tgt gag gcc caa ggc tcc cca cca ggc ctt      935
 Ala Gln Gln Glu Arg Tyr Cys Glu Ala Gln Gly Ser Pro Pro Gly Leu
                 180                 185                 190

 aag tcc cca gag agg ttc cag agg gtt cag cgc cca gac aga aaa agc      983
 Lys Ser Pro Glu Arg Phe Gln Arg Val Gln Arg Pro Asp Arg Lys Ser
             195                 200                 205

 tcg aaa ctt cct ata caa gcc aga gct ctg gag agg aac aga ccg cac     1031
 Ser Lys Leu Pro Ile Gln Ala Arg Ala Leu Glu Arg Asn Arg Pro His
         210                 215                 220

 atg tca gag ccc att aag cat ttc cat cca gcc tga aaag gccaggagag     1081
 Met Ser Glu Pro Ile Lys His Phe His Pro Ala 
     225                 230

 tcaggccacc agggggcgcc agagaaccac aggagatcca ggaagcgctt gctaggacca   1141

 agctcccagc tcccaggacc cccaggccgg cagcggagtc caggagctgg tgtggcccac   1201

 aaagggtcgg agagcctccc agtgagaaca gtaggggcag gaaaatgatc aggtcaaggg   1261

 tctcccagct ggcagagagg gctcccagca gagtgaggac ttcattctct agggcagacc   1321

 acgcccactg gaggaaggaa tgtacatcct gggaggcctc taagctcccc agactcaaat   1381

 gccagcagct cacatactgg agaagaggaa gcctggaatt tacagggtgc agaggggctg   1441

 ggcagcagcc ttcctgccat tctgcagaac ctgtcagctt caaagggagg ctccactctg   1501

 cggtggcaaa gctgggcctg acccttctgg ccaagatgtc ctggtcccca cagctcgcca   1561

 agcgcaagca cttggcccct aacctgagcc tgagggaacc tgattctact ctgcctccca   1621

 aagtgggtga tcctcgtgca ggggaggaca gcatcggaga tcacactgct tcacagaggg   1681

 atcttcagct gcaaggtcac tgctgtactg gggccaccct tcctaagaca gagagtcccc   1741

 agggccagga ggcacctggg aacccaaatg gggctccaca gaatacacga gcctccaaaa   1801

 agtttagtat tatgaagcat ctgaattttt ttctcttcca gaatggcttt aaaaagtaga   1861

 ctcaggccca gagtcctcag gacatatcag aaaagctttg agagtgtcct gatccctgca   1921

 aagcctctaa taaattggtc atttgggaaa aaaaaaaaaa                         1961




      <210> 342
      <211> 2541
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (454)..(924)

      <400> 342
 gcggtagagg tgtatatttt tcatactgtg gggcaaagta tttgtgctgc tttttggaga     60

 tggactggaa cgtctggttt ctgtccccgg gcccggcagc tacgtctatt ttctgtagaa    120

 ggtgccacag tgagacctgg agccacccct tcctgccctg gcgccgttta gagctgggag    180

 cccgtggact cccggcctgt ttctaccttc tattcaacca ctctgacgtg gggagacaag    240

 aagaaataga actttttgat agtgtggtaa aaacattgat ttgaactatt ttagtaaaag    300

 gagtaacaaa caagattgtg atagtgtcta ctttgagcta gataaataaa ggcctctttg    360

 tgagcctcct ggctgggtgc tcagtgcttg tttctgtcgt gggtggcagg gtcagcaggc    420

 agagacaggg ccaaggcccc tcaagcaccg cag atg ggg gct cag tcg ggg ccc     474
                                      Met Gly Ala Gln Ser Gly Pro
                                        1               5

 ctt cca cag aca gag ccg tgg ccc ctc aag gtg gac agt gag gcc gct      522
 Leu Pro Gln Thr Glu Pro Trp Pro Leu Lys Val Asp Ser Glu Ala Ala
          10                  15                  20

 gct cct cca gct gcc tct gtc tca tca cag gcc aga agt gga aag ggt      570
 Ala Pro Pro Ala Ala Ser Val Ser Ser Gln Ala Arg Ser Gly Lys Gly
      25                  30                  35

 ttc aaa tcc aag ccc ccg ggt tcc tgt gtg cgt tct acg cag caa ggc      618
 Phe Lys Ser Lys Pro Pro Gly Ser Cys Val Arg Ser Thr Gln Gln Gly
  40                  45                  50                  55

 ttc aaa gtt tca aac tgg ttt gga act caa cca ggt cct cca aag gaa      666
 Phe Lys Val Ser Asn Trp Phe Gly Thr Gln Pro Gly Pro Pro Lys Glu
                  60                  65                  70

 acc aag gca ggc aca gga tgg ggg cag gct ggc ttg gca ggc agc tgt      714
 Thr Lys Ala Gly Thr Gly Trp Gly Gln Ala Gly Leu Ala Gly Ser Cys
              75                  80                  85

 gcg gat cca ccc aga gtg cct tgg gag gca gtg ggg ttg gct gtg gct      762
 Ala Asp Pro Pro Arg Val Pro Trp Glu Ala Val Gly Leu Ala Val Ala
          90                  95                 100

 gct gtg agc tgc agc cag gcc tct ccc gcg tcc cca ggg tct gga agg      810
 Ala Val Ser Cys Ser Gln Ala Ser Pro Ala Ser Pro Gly Ser Gly Arg
     105                 110                 115

 agg gcc tct gca cat ttt ata agc cac aga ctg cga agg cct gga gcc      858
 Arg Ala Ser Ala His Phe Ile Ser His Arg Leu Arg Arg Pro Gly Ala
 120                 125                 130                 135

 cca cct tcc acc cat aac aaa gaa agg gat agt ttc aga act gct ttt      906
 Pro Pro Ser Thr His Asn Lys Glu Arg Asp Ser Phe Arg Thr Ala Phe
                 140                 145                 150

 att tgg ata act gac tga aggagt ctcatttgta accaagatgg aattcacagt      960
 Ile Trp Ile Thr Asp 
             155

 atgttgttac attcacactt aaaaaatata tctctatgta caggaatttg caaagagatg   1020

 taaacataca ttaatttcca agtacatttt tccccttctc cctggaggaa aaaaaaaaaa   1080

 gccatccaat gaggcaaccc cttcaaaata attttaatac aaaggatgca aacatctata   1140

 aatgaaaaat gtggttcttc tgccccttct gggtgtcatg ggagagaatg tcaccgaatg   1200

 aaaatgacaa cagcttggct tcagatggaa ttggactatt taaaattgag tttccaggaa   1260

 aaataggcac tgatttctag aaggaaatta actccttacc gaagctattt attgagccaa   1320

 tatggctggt taacgtcctc actagtataa agtaacccag tgcaggactc tcagacatta   1380

 gctgaaccaa gtgtacacag tcagactgca agggcactga tgaggctact ctgaaagctg   1440

 gttgtccccg tcctctaggt gtgaggacca ctctgatttt atcccagggg cccggtccat   1500

 tcttcccata ctgcaactgt cgtgcattat acaaggtacc ctgctgctta cccacttcaa   1560

 ctactctgca agtcgattag aaaatcttgt taaaaaaaca aagagggaaa aaaggctcac   1620

 gttatctcat ccaggctgcc cgccccagcc ccccaactgg aggcatgccg ggtgggggaa   1680

 tgggcggggg cacaggaggc tgtcctccag gggggacggc aggaggtggg tagctggctg   1740

 gcggcaggcc caaccctgga ggaggatgag gggggactgc gtgggtaggc gggaggcgtg   1800

 ggggtggggg tgggaagttg gggttgtagg tgggtggggg tggggggtag ccaggagtag   1860

 ggggtgggat ggcaggtggg ggccaggagg ctgggggagg aggcacaggt ggcgggggcg   1920

 ggttgggcgg gtagacatgg gggtggtagg gcaggtgtgc aggtgggccg taggcggggg   1980

 gcagggcacc gtagggaggg tccctcggtc ttcatcatgg actgcaggct ctggtagccc   2040

 tctccagaca tgtaggagct ggtggtggac atcccggtca tgtagctgga ggggggtggg   2100

 ggcgggggcc ggtgtggcag cggcggtggc tggtgcacag gggccgggtg ggccggaggg   2160

 ggaatctgga ctttggggag gtcagtggca tccacagggc ccggcggctc agcctcacct   2220

 aaggcagcag cgaggggagg cttccggtct ggaggtgggt gggctggagg caacggtgga   2280

 tgagtggtct caattttggg gattttaggt ggtggtggtt ctgctgcttt gttctcttct   2340

 ttgggagaaa caaccacggc tcgcttaacc tgtcggggag aactgggctg cggagagggt   2400

 ttcttgggct gttgggctgc ctgctgctgc tgggctggtt gctgggggtc cttccgctgg   2460

 ggctggccag caaagattcc catgcttggc tcctcgtgcc aagctggcgt agcaggtccg   2520

 acggtatcag ggtttcaaaa g                                             2541




      <210> 343
      <211> 1053
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (274)..(993)

      <400> 343
 ctctaaacag gttagctcct ccatgacata tagttttggc atgaaaggtg gatctaaggc     60

 taccagagag aaagagttag aaatgagtgt agacttcctc tagcatcttt tcatacttaa    120

 ttaagaaaga gaaggaactt agcctttatc atggtataga tttgattgac ttaggcccac    180

 atatctgcaa gggtcagcca aatttaaatt gtaaacatgt ttttagaaaa tctgaattcc    240

 ccagcacgat tggcttgagc gattggaaac aag atg cag gac ccc aac aca gac     294
                                      Met Gln Asp Pro Asn Thr Asp
                                        1               5

 act gag tgg aat gac atc tta gac aag aag ggc atc tta ccc acc aag      342
 Thr Glu Trp Asn Asp Ile Leu Asp Lys Lys Gly Ile Leu Pro Thr Lys
          10                  15                  20

 gaa agt ata aaa gaa tca gaa gag aag gca gaa gag gag cag cac atc      390
 Glu Ser Ile Lys Glu Ser Glu Glu Lys Ala Glu Glu Glu Gln His Ile
      25                  30                  35

 ctt cag cag tca gtg gtg aca aca tac gaa gat atg act ttg gaa gag      438
 Leu Gln Gln Ser Val Val Thr Thr Tyr Glu Asp Met Thr Leu Glu Glu
  40                  45                  50                  55

 ctg gag gat cat gaa gac gag ttt aat gag gag gat gaa cat gct att      486
 Leu Glu Asp His Glu Asp Glu Phe Asn Glu Glu Asp Glu His Ala Ile
                  60                  65                  70

 gaa atg tac aga tgg cag aga ctc gct gag ggg aaa gca att aaa ctg      534
 Glu Met Tyr Arg Trp Gln Arg Leu Ala Glu Gly Lys Ala Ile Lys Leu
              75                  80                  85

 aag aat aaa ttt gga gaa gtt ttg gag att tca ggg aag tat tat gtt      582
 Lys Asn Lys Phe Gly Glu Val Leu Glu Ile Ser Gly Lys Tyr Tyr Val
          90                  95                 100

 caa gaa gtt acc aaa gcc agt gag ggc ttg tgg gtc atc ttg cac ctt      630
 Gln Glu Val Thr Lys Ala Ser Glu Gly Leu Trp Val Ile Leu His Leu
     105                 110                 115

 tgc aaa cga gga att ccc ctc tgt gcc ctg ata aat cag cac ctc agt      678
 Cys Lys Arg Gly Ile Pro Leu Cys Ala Leu Ile Asn Gln His Leu Ser
 120                 125                 130                 135

 gga ctt gcc agg agg ttt cct gat gtc aaa ttt atc aaa gcc aat tca      726
 Gly Leu Ala Arg Arg Phe Pro Asp Val Lys Phe Ile Lys Ala Asn Ser
                 140                 145                 150

 acc acc cgc ata ccc aat tat cct gat agg aat ctg ccc atg gta ttt      774
 Thr Thr Arg Ile Pro Asn Tyr Pro Asp Arg Asn Leu Pro Met Val Phe
             155                 160                 165

 gtt tac ttg gaa gga gac atc aag gct cag ttg atc ggt cct ctg gtg      822
 Val Tyr Leu Glu Gly Asp Ile Lys Ala Gln Leu Ile Gly Pro Leu Val
         170                 175                 180

 ttt ggc ggc atg aac ctg acc aga gat gag ttg ggg tgg aaa ctg tct      870
 Phe Gly Gly Met Asn Leu Thr Arg Asp Glu Leu Gly Trp Lys Leu Ser
     185                 190                 195

 gaa tct aga gca gtt aag acg gac ttg gag gaa aac cct aag aag ccg      918
 Glu Ser Arg Ala Val Lys Thr Asp Leu Glu Glu Asn Pro Lys Lys Pro
 200                 205                 210                 215

 att gaa ggt gta ttg ctg tct tca gtg cag agc tct gtc ccc atg agg      966
 Ile Glu Gly Val Leu Leu Ser Ser Val Gln Ser Ser Val Pro Met Arg
                 220                 225                 230

 agg gac agc gat tcc aag ggt gac tga ggctg cagctgctat cacatgctga     1018
 Arg Asp Ser Asp Ser Lys Gly Asp 
             235

 actttcttgt gacaaattgt ctggatttct ttaag                              1053




      <210> 344
      <211> 1446
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1329)

      <400> 344
  atg cca tgt ggc aaa caa gga aat ttg caa gtt ccc ggt tcc aag gtg      48
  Met Pro Cys Gly Lys Gln Gly Asn Leu Gln Val Pro Gly Ser Lys Val
    1               5                  10                  15

 tta cct ggc ttg gga gaa ggt tgt aaa gaa atg tgg ctt cga aag gta       96
 Leu Pro Gly Leu Gly Glu Gly Cys Lys Glu Met Trp Leu Arg Lys Val
              20                  25                  30

 atc tac gga ggt gag gtc tgg ggg aag tcc cca gaa cct gag ttc ccc      144
 Ile Tyr Gly Gly Glu Val Trp Gly Lys Ser Pro Glu Pro Glu Phe Pro
          35                  40                  45

 tca ctc gtg aac ctg tgc cag agt tgg aaa att aac aat ttg atg tca      192
 Ser Leu Val Asn Leu Cys Gln Ser Trp Lys Ile Asn Asn Leu Met Ser
      50                  55                  60

 act gtc cac agt gat gag gct ggt atg ctg tcc tac ttt ctg ttt gaa      240
 Thr Val His Ser Asp Glu Ala Gly Met Leu Ser Tyr Phe Leu Phe Glu
  65                  70                  75                  80

 gag ctg atg cga tgt gac aaa gat tcc atg cca gat gga aat ctg tca      288
 Glu Leu Met Arg Cys Asp Lys Asp Ser Met Pro Asp Gly Asn Leu Ser
                  85                  90                  95

 gag gag gaa aaa ttg ttt ctc tca tat ttt cct ttg cac aag ttt gag      336
 Glu Glu Glu Lys Leu Phe Leu Ser Tyr Phe Pro Leu His Lys Phe Glu
             100                 105                 110

 cta gaa cag aac atc aaa gaa ctt aac acc ctt gcg gac caa gtt gac      384
 Leu Glu Gln Asn Ile Lys Glu Leu Asn Thr Leu Ala Asp Gln Val Asp
         115                 120                 125

 acc act cac gag ttg ctt acc aag acc agc ctg gtg gcc agc tct tcc      432
 Thr Thr His Glu Leu Leu Thr Lys Thr Ser Leu Val Ala Ser Ser Ser
     130                 135                 140

 ggg gct gtt tct ggg gtc atg aac atc ctg ggt ttg gcc cta gca cct      480
 Gly Ala Val Ser Gly Val Met Asn Ile Leu Gly Leu Ala Leu Ala Pro
 145                 150                 155                 160

 gtg aca gca gga ggc agt ctc atg ctc tca gca act ggg aca ggg ttg      528
 Val Thr Ala Gly Gly Ser Leu Met Leu Ser Ala Thr Gly Thr Gly Leu
                 165                 170                 175

 ggg gca gca gct gcc atc acc aac ata gta aca aat gtc tta gaa aat      576
 Gly Ala Ala Ala Ala Ile Thr Asn Ile Val Thr Asn Val Leu Glu Asn
             180                 185                 190

 aga agc aat tca gca gca aga gac aaa gcc agc cga ctg ggg cct ctg      624
 Arg Ser Asn Ser Ala Ala Arg Asp Lys Ala Ser Arg Leu Gly Pro Leu
         195                 200                 205

 aca aca tca cat gag gct ttc gga gga ata aat tgg tct gaa atc gag      672
 Thr Thr Ser His Glu Ala Phe Gly Gly Ile Asn Trp Ser Glu Ile Glu
     210                 215                 220

 gct gct ggc ttt tgt gtt aat aag tgt gta aaa gct atc cag ggc atc      720
 Ala Ala Gly Phe Cys Val Asn Lys Cys Val Lys Ala Ile Gln Gly Ile
 225                 230                 235                 240

 aag gat ctt cat gcc tac cag atg gcc aaa tcc aac tct ggc ttc atg      768
 Lys Asp Leu His Ala Tyr Gln Met Ala Lys Ser Asn Ser Gly Phe Met
                 245                 250                 255

 gct atg gtc aag aat ttt gtg gcc aag aga cac atc cct ttc tgg acg      816
 Ala Met Val Lys Asn Phe Val Ala Lys Arg His Ile Pro Phe Trp Thr
             260                 265                 270

 gct aga ggg gtg cag aga gcc ttt gag ggc aca act ctg gcc atg acc      864
 Ala Arg Gly Val Gln Arg Ala Phe Glu Gly Thr Thr Leu Ala Met Thr
         275                 280                 285

 aat ggt gcc tgg gtg atg ggt gct gct ggg gct ggc ttc tta ctt atg      912
 Asn Gly Ala Trp Val Met Gly Ala Ala Gly Ala Gly Phe Leu Leu Met
     290                 295                 300

 aaa gac atg agc agc ttc ctg cag agc tgg aag cac ctg gag gat ggg      960
 Lys Asp Met Ser Ser Phe Leu Gln Ser Trp Lys His Leu Glu Asp Gly
 305                 310                 315                 320

 gca agg acg gag aca gca gag gaa ctg aga gca ctt gct aag aag ctg     1008
 Ala Arg Thr Glu Thr Ala Glu Glu Leu Arg Ala Leu Ala Lys Lys Leu
                 325                 330                 335

 gag cag gag ctg gac cgg ctc acc cag cac cac cgg cac ctg ccg cag     1056
 Glu Gln Glu Leu Asp Arg Leu Thr Gln His His Arg His Leu Pro Gln
             340                 345                 350

 aag gcg agc cag acc tgt tcc agc tcc cgg ggc agg gct gtt cga gga     1104
 Lys Ala Ser Gln Thr Cys Ser Ser Ser Arg Gly Arg Ala Val Arg Gly
         355                 360                 365

 tcc cgt gtg gtt aaa cca gaa ggg tct cgc tca cct ctc ccc tgg cct     1152
 Ser Arg Val Val Lys Pro Glu Gly Ser Arg Ser Pro Leu Pro Trp Pro
     370                 375                 380

 gtt gtg gag cac cag cct agg ctg ggc cct ggc gtg gca ctg agg aca     1200
 Val Val Glu His Gln Pro Arg Leu Gly Pro Gly Val Ala Leu Arg Thr
 385                 390                 395                 400

 cca aag agg aca gtc tct gcc cca agg atg ctt ggc cac cag cca gcc     1248
 Pro Lys Arg Thr Val Ser Ala Pro Arg Met Leu Gly His Gln Pro Ala
                 405                 410                 415

 cac cag cac cag caa gaa agg gga gac agg ccc cgg gaa gac acc gac     1296
 His Gln His Gln Gln Glu Arg Gly Asp Arg Pro Arg Glu Asp Thr Asp
             420                 425                 430

 aat gag aag agt tgg tca ccc tgt cac cac tga accttgat ttaacagagg     1347
 Asn Glu Lys Ser Trp Ser Pro Cys His His 
         435                 440

 caaaatgcaa gtcttccctg aagaatactg ggggtaggga aacttctagt ggcaatgata   1407

 aaaccagcag caatgataat agaaggcaaa aaaaaaaaa                          1446




      <210> 345
      <211> 836
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (506)..(811)

      <220>
      <221> misc_feature
      <222> (1)...(836)
      <223> n = a,t,c or g

      <400> 345
 aggaaccntc cccggacacg gggtcacggg gtcatagcca aaggcaactg ccaccggccc     60

 cttgtcgagg ccggagccct ccggtgggga gcggccaaga agttctgaca tggtggggag    120

 acttgccccc ctgtcctagg tcgggggcca cttctcaagc ttgtgcacca cacgctgaag    180

 gtgcaccaga cgctgcgaga ggagctggca agggtgagga ccctggaggg catcgctgct    240

 gtgagccagg agctgaagct gcggtgtcag gaggagatat ccaggcagga gggagcgaag    300

 cccaccggcg acttgccctt ccactggatn tgccagccnt acatccggcc ggggcccagg    360

 gaggggagca aggagaaggc aggtgcgcgc agcaagcggg ccctggagga agagaagggt    420

 ggcacggagg tcctgtccaa gaacaagcaa aagaagcagc tgaggaaccc ccacaagacc    480

 ttcgacccct ctctgaagcc aaaat  atg caa agt gtg acc agt gtg gaa acc     532
                              Met Gln Ser Val Thr Ser Val Glu Thr
                                1               5

 caa agg gca aca gat gtg tgt tca gcc tgt gcc gcg gct gct gca aga      580
 Gln Arg Ala Thr Asp Val Cys Ser Ala Cys Ala Ala Ala Ala Ala Arg
  10                  15                  20                  25

 agc gag cct cca aag gag act gca gac tgc cca gga ctg ctg ctg gag      628
 Ser Glu Pro Pro Lys Glu Thr Ala Asp Cys Pro Gly Leu Leu Leu Glu
                  30                  35                  40

 cct gga cac gtc cta ctt aag aaa atg cct ttt act cag gga atc tcc      676
 Pro Gly His Val Leu Leu Lys Lys Met Pro Phe Thr Gln Gly Ile Ser
              45                  50                  55

 tgc tac tta atg tgg aaa gac acg ccc atg tcc ccc ttc ggc cca ctc      724
 Cys Tyr Leu Met Trp Lys Asp Thr Pro Met Ser Pro Phe Gly Pro Leu
          60                  65                  70

 tgg ggg cct gga aat gct gca gtg ggg agc agg ccc cag gct gga cct      772
 Trp Gly Pro Gly Asn Ala Ala Val Gly Ser Arg Pro Gln Ala Gly Pro
      75                  80                  85

 gcc ctg tcc tca gca cgc gtg tgc aaa agt gaa caa taa atcatttcaa       821
 Ala Leu Ser Ser Ala Arg Val Cys Lys Ser Glu Gln 
  90                  95                 100

 agatgaaaaa aaaaa                                                     836




      <210> 346
      <211> 3912
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (490)..(3531)

      <400> 346
 tttcgtggtt cgtggccttc cgtgcagccg cgggaggcac cgcgggaagc aatccctgag     60

 cgaggcaatg ggtttcgcct cttgtctgcc aggctctgcg ccctgcgccc ggatgacagc    120

 agctccgccc gcaccgagat ccacctgctc ttcgatcagc tcatctccga gaactacagc    180

 gagggcagtg gcgtggcccc ggaggacgtt agtgctcttc ttgtccaggc ttgccgactg    240

 gtacctctta atcagaatca tcttgtcagc aaagtgagcc agcttatcca ccatttactt    300

 aacagattac aggtaattgt tgatgaacag cacttggatt tcctgttggc atatactatt    360

 tcggctattc atcagtgtag ttcctggaca cacagggaaa ttcttcaagc cctggcagct    420

 ctggtgtact gcaatggctc caaatgtcaa aagtacctcc cagagctgct aggcaacacc    480

 ggactctta    atg aag ttg agt gac ttg gct cag tct gat cct gaa gtc     528
              Met Lys Leu Ser Asp Leu Ala Gln Ser Asp Pro Glu Val
                1               5                  10

 agg aga gct gca gta cat tgt atg gca aac tta tgt ctc agt gtg cca      576
 Arg Arg Ala Ala Val His Cys Met Ala Asn Leu Cys Leu Ser Val Pro
      15                  20                  25

 gga cag ccg tat ttg gag gag ccc tac caa aat gtc tgt ttc caa gct      624
 Gly Gln Pro Tyr Leu Glu Glu Pro Tyr Gln Asn Val Cys Phe Gln Ala
  30                  35                  40                  45

 ttt ctg act att tta cag tct cca aaa tca tct gat atg gat gat atc      672
 Phe Leu Thr Ile Leu Gln Ser Pro Lys Ser Ser Asp Met Asp Asp Ile
                  50                  55                  60

 aca ttt tgc atg tta ttg caa aat gca tta aaa ggt ata cag tca ctt      720
 Thr Phe Cys Met Leu Leu Gln Asn Ala Leu Lys Gly Ile Gln Ser Leu
              65                  70                  75

 cta aat ggt ggg aga atg aaa cta aca cag act gat gaa ctt gga gca      768
 Leu Asn Gly Gly Arg Met Lys Leu Thr Gln Thr Asp Glu Leu Gly Ala
          80                  85                  90

 ctt tta gct gtg cta aag aaa ttc atg ttt cac gga ctc cct gga cta      816
 Leu Leu Ala Val Leu Lys Lys Phe Met Phe His Gly Leu Pro Gly Leu
      95                 100                 105

 aac ata gag atg ccc acg gtg tta tac cca act ccg ctt cct cag tat      864
 Asn Ile Glu Met Pro Thr Val Leu Tyr Pro Thr Pro Leu Pro Gln Tyr
 110                 115                 120                 125

 gat ggg cga aca cct atc aaa cca cag caa tca gaa tcc agt gct tct      912
 Asp Gly Arg Thr Pro Ile Lys Pro Gln Gln Ser Glu Ser Ser Ala Ser
                 130                 135                 140

 cga cca act ttg aat aaa aag aaa aaa tcc gaa gta aaa cca aag aaa      960
 Arg Pro Thr Leu Asn Lys Lys Lys Lys Ser Glu Val Lys Pro Lys Lys
             145                 150                 155

 atc cag caa gga gag gag gag gaa aag gaa tcc agt ggt gaa ata gag     1008
 Ile Gln Gln Gly Glu Glu Glu Glu Lys Glu Ser Ser Gly Glu Ile Glu
         160                 165                 170

 gca gcc cca gtc act ggc aca ggc aga gtg aac ctg cat gaa ggg aac     1056
 Ala Ala Pro Val Thr Gly Thr Gly Arg Val Asn Leu His Glu Gly Asn
     175                 180                 185

 act tgg tgt ccc tcc tcc ctg ggt gtc cag agt ttg cct tta gat gga     1104
 Thr Trp Cys Pro Ser Ser Leu Gly Val Gln Ser Leu Pro Leu Asp Gly
 190                 195                 200                 205

 agt gga gct gca gaa aaa gat gga gtc tcc tca tcc ttc agt tct tcc     1152
 Ser Gly Ala Ala Glu Lys Asp Gly Val Ser Ser Ser Phe Ser Ser Ser
                 210                 215                 220

 agt tgg aaa agg gtc agc agt agt gag tca gac ttt tct gat gct gaa     1200
 Ser Trp Lys Arg Val Ser Ser Ser Glu Ser Asp Phe Ser Asp Ala Glu
             225                 230                 235

 gga ggc atg cag agt aaa atg agg tct tac caa gct aaa gtt cgc caa     1248
 Gly Gly Met Gln Ser Lys Met Arg Ser Tyr Gln Ala Lys Val Arg Gln
         240                 245                 250

 gga gcc tta gtt tgt ttt ctt tct act ata aaa tcg ata gaa aaa aaa     1296
 Gly Ala Leu Val Cys Phe Leu Ser Thr Ile Lys Ser Ile Glu Lys Lys
     255                 260                 265

 gtt ctt tat ggc tac tgg tca gct ttt att cct gat acg cct gaa ctt     1344
 Val Leu Tyr Gly Tyr Trp Ser Ala Phe Ile Pro Asp Thr Pro Glu Leu
 270                 275                 280                 285

 ggc agc cca cag tca gtg tcc ttg atg act ctt aca ttg aaa gac cct     1392
 Gly Ser Pro Gln Ser Val Ser Leu Met Thr Leu Thr Leu Lys Asp Pro
                 290                 295                 300

 tct cca aag aca cgt gcc tgt gct ctg caa gtt tta tct gcc atc ttg     1440
 Ser Pro Lys Thr Arg Ala Cys Ala Leu Gln Val Leu Ser Ala Ile Leu
             305                 310                 315

 gaa ggc tca aag cag ttt ctt tct gtt gct gaa gat acc agt gac cac     1488
 Glu Gly Ser Lys Gln Phe Leu Ser Val Ala Glu Asp Thr Ser Asp His
         320                 325                 330

 aga agg gct ttt acc ccc ttc tcc gta atg atc gct tgc agc att aga     1536
 Arg Arg Ala Phe Thr Pro Phe Ser Val Met Ile Ala Cys Ser Ile Arg
     335                 340                 345

 gag ttg cac aga tgt ctt ttg tta gct ttg gtg gcg gag tca tcc tca     1584
 Glu Leu His Arg Cys Leu Leu Leu Ala Leu Val Ala Glu Ser Ser Ser
 350                 355                 360                 365

 cag acc gtt act cag ata att aag tgc ctt gca aat tta gta tca aat     1632
 Gln Thr Val Thr Gln Ile Ile Lys Cys Leu Ala Asn Leu Val Ser Asn
                 370                 375                 380

 gca cct tat gat cgt cta aaa ctc agc ctg ctg acc aaa gtc tgg aac     1680
 Ala Pro Tyr Asp Arg Leu Lys Leu Ser Leu Leu Thr Lys Val Trp Asn
             385                 390                 395

 cag ata aag cct tat att cgc cac aaa gat gtt aat gtt cgt gtg tca     1728
 Gln Ile Lys Pro Tyr Ile Arg His Lys Asp Val Asn Val Arg Val Ser
         400                 405                 410

 agt ctc aca ctc ttg gga gct ata gtg tcc acc cac gca cct tta cct     1776
 Ser Leu Thr Leu Leu Gly Ala Ile Val Ser Thr His Ala Pro Leu Pro
     415                 420                 425

 gaa gtc caa cta ctt ctg caa cag cca tgt tct tct gga ctc ggt aat     1824
 Glu Val Gln Leu Leu Leu Gln Gln Pro Cys Ser Ser Gly Leu Gly Asn
 430                 435                 440                 445

 agc aat tca gca acc cct cac ctc agc cct cct gat tgg tgg aag aaa     1872
 Ser Asn Ser Ala Thr Pro His Leu Ser Pro Pro Asp Trp Trp Lys Lys
                 450                 455                 460

 acc cct gca gga ccc tct ctg gaa gaa acg tca gtt agc tca cct aag     1920
 Thr Pro Ala Gly Pro Ser Leu Glu Glu Thr Ser Val Ser Ser Pro Lys
             465                 470                 475

 ggg tct tca gag ccc tgc tgg ctc att cga ctt tgc att tcc att gtc     1968
 Gly Ser Ser Glu Pro Cys Trp Leu Ile Arg Leu Cys Ile Ser Ile Val
         480                 485                 490

 gta ctg ccc aag gag gat tcc tgt tca ggt agc gat gct ggc tct gca     2016
 Val Leu Pro Lys Glu Asp Ser Cys Ser Gly Ser Asp Ala Gly Ser Ala
     495                 500                 505

 gca gga agc acc tac gaa cca tcc ccc atg cga ctg gag gcc tta cag     2064
 Ala Gly Ser Thr Tyr Glu Pro Ser Pro Met Arg Leu Glu Ala Leu Gln
 510                 515                 520                 525

 gta ttg act ctt ctg gca agg ggc tac ttt tca atg act caa gcc tac     2112
 Val Leu Thr Leu Leu Ala Arg Gly Tyr Phe Ser Met Thr Gln Ala Tyr
                 530                 535                 540

 ttg atg gag ctt gga gag gtg att tgc aag tgc atg ggg gaa gca gat     2160
 Leu Met Glu Leu Gly Glu Val Ile Cys Lys Cys Met Gly Glu Ala Asp
             545                 550                 555

 cca tcc att cag ctt cat gga gca aag ctt ctg gaa gaa ctg ggc aca     2208
 Pro Ser Ile Gln Leu His Gly Ala Lys Leu Leu Glu Glu Leu Gly Thr
         560                 565                 570

 ggc tta ata cag cag tat aaa cca gac tcc act gca gca cct gat cag     2256
 Gly Leu Ile Gln Gln Tyr Lys Pro Asp Ser Thr Ala Ala Pro Asp Gln
     575                 580                 585

 aga gca cca gtc ttc ttg gtg gtg atg ttc tgg act atg atg ctg aac     2304
 Arg Ala Pro Val Phe Leu Val Val Met Phe Trp Thr Met Met Leu Asn
 590                 595                 600                 605

 ggt cct tta ccc aga gcc ctg cag aat tca gaa cac cca act ctc cag     2352
 Gly Pro Leu Pro Arg Ala Leu Gln Asn Ser Glu His Pro Thr Leu Gln
                 610                 615                 620

 gcg agc gcc tgt gat gcc ctg tct tcc atc ttg cca gag gcc ttc agc     2400
 Ala Ser Ala Cys Asp Ala Leu Ser Ser Ile Leu Pro Glu Ala Phe Ser
             625                 630                 635

 aat ctg ccg aat gac agg cag atg ctg tgc atc aca gtg ctg ctc ggg     2448
 Asn Leu Pro Asn Asp Arg Gln Met Leu Cys Ile Thr Val Leu Leu Gly
         640                 645                 650

 ctg aat gac agc aag aat cgc tta gtg aaa gct gca act tca cgg gcc     2496
 Leu Asn Asp Ser Lys Asn Arg Leu Val Lys Ala Ala Thr Ser Arg Ala
     655                 660                 665

 ctg gga gtc tat gtg ctt ttt ccc tgt ctc aga cag gat gtc ata ttt     2544
 Leu Gly Val Tyr Val Leu Phe Pro Cys Leu Arg Gln Asp Val Ile Phe
 670                 675                 680                 685

 gtt gca gac gca gca aat gca ata ttg atg tca ctt gaa gac aag tct     2592
 Val Ala Asp Ala Ala Asn Ala Ile Leu Met Ser Leu Glu Asp Lys Ser
                 690                 695                 700

 ctg aat gtt cga gcc aaa gca gcc tgg tcc ctg ggc aac ctg aca gac     2640
 Leu Asn Val Arg Ala Lys Ala Ala Trp Ser Leu Gly Asn Leu Thr Asp
             705                 710                 715

 act ctg att gtc aac atg gaa aca cca gac cca agt ttc cag gaa gag     2688
 Thr Leu Ile Val Asn Met Glu Thr Pro Asp Pro Ser Phe Gln Glu Glu
         720                 725                 730

 ttc tct ggt ctc ctg ctc ttg aaa atg tta cga tca gct ata gaa gca     2736
 Phe Ser Gly Leu Leu Leu Leu Lys Met Leu Arg Ser Ala Ile Glu Ala
     735                 740                 745

 tcc aag gat aaa gac aag gta aaa agc aat gca gtc cgg gcc ctt gga     2784
 Ser Lys Asp Lys Asp Lys Val Lys Ser Asn Ala Val Arg Ala Leu Gly
 750                 755                 760                 765

 aat ttg ctt cat ttt ctg caa ccc tct cat ata gaa aaa ccc aca ttt     2832
 Asn Leu Leu His Phe Leu Gln Pro Ser His Ile Glu Lys Pro Thr Phe
                 770                 775                 780

 gca gaa atc att gag gag tct atc cag gcc cta att tct act gtt cta     2880
 Ala Glu Ile Ile Glu Glu Ser Ile Gln Ala Leu Ile Ser Thr Val Leu
             785                 790                 795

 aca gaa gct gcc atg aaa gtc cga tgg aat gct tgt tat gca atg gga     2928
 Thr Glu Ala Ala Met Lys Val Arg Trp Asn Ala Cys Tyr Ala Met Gly
         800                 805                 810

 aat gta ttt aaa aat cct gcc ctt cct tta ggg aca gcc cca tgg acc     2976
 Asn Val Phe Lys Asn Pro Ala Leu Pro Leu Gly Thr Ala Pro Trp Thr
     815                 820                 825

 tcc cag gcc tac aat gcc ctg aca tcg gtc gtg aca tca tgc aag aac     3024
 Ser Gln Ala Tyr Asn Ala Leu Thr Ser Val Val Thr Ser Cys Lys Asn
 830                 835                 840                 845

 ttc aaa gtg cgc atc aga tct gca gct gcc ctt tcc gtc ccg ggg aag     3072
 Phe Lys Val Arg Ile Arg Ser Ala Ala Ala Leu Ser Val Pro Gly Lys
                 850                 855                 860

 aga gag cag tac ggg tct gtt gac cag tat gct cgg atc tgg aat gca     3120
 Arg Glu Gln Tyr Gly Ser Val Asp Gln Tyr Ala Arg Ile Trp Asn Ala
             865                 870                 875

 ttg gtc acc gct tta cag aag agt gaa gac acc ata gac ttt ttg gaa     3168
 Leu Val Thr Ala Leu Gln Lys Ser Glu Asp Thr Ile Asp Phe Leu Glu
         880                 885                 890

 ttc aag tac tgt gtc agc cta cgg acc caa atc tgc cag gca ctg att     3216
 Phe Lys Tyr Cys Val Ser Leu Arg Thr Gln Ile Cys Gln Ala Leu Ile
     895                 900                 905

 cac ctc ttg agc ttg gcc agt gcc tcg gac ctc cct tgt atg aaa gaa     3264
 His Leu Leu Ser Leu Ala Ser Ala Ser Asp Leu Pro Cys Met Lys Glu
 910                 915                 920                 925

 acc ctt gaa ctg agt ggg aat atg gtc cag tcc tat att cta cag ttt     3312
 Thr Leu Glu Leu Ser Gly Asn Met Val Gln Ser Tyr Ile Leu Gln Phe
                 930                 935                 940

 tta aaa tca gga gca gag gga gat gac act gga gca ccc cac agc cca     3360
 Leu Lys Ser Gly Ala Glu Gly Asp Asp Thr Gly Ala Pro His Ser Pro
             945                 950                 955

 cag gaa aga gac cag atg gtc aga atg gcc ctt aaa cac atg ggc agc     3408
 Gln Glu Arg Asp Gln Met Val Arg Met Ala Leu Lys His Met Gly Ser
         960                 965                 970

 atc cag gca cca act gga gac aca gcc aga agg gcc atc atg ggc ttt     3456
 Ile Gln Ala Pro Thr Gly Asp Thr Ala Arg Arg Ala Ile Met Gly Phe
     975                 980                 985

 tta gaa gag atc ctg gcc gtt tgt ttt gac tca tct gga tca caa ggg     3504
 Leu Glu Glu Ile Leu Ala Val Cys Phe Asp Ser Ser Gly Ser Gln Gly
 990                 995                1000                1005

 gca ctc cca ggg tta aca aat cag tga agatc ccaccatact ttctagatgt     3556
 Ala Leu Pro Gly Leu Thr Asn Gln 
                1010

 cgaaggcggc agtaggaaga cctgagcttg agcataagat ctgtgggatt tcatcttagg   3616

 ggcagaaaca atccgttcac tatttattta gaatgactta gcagccattt aaattttcac   3676

 agagggctca accacctttg gagtgactcc atagcactgg ccatggtcag ggttgttgga   3736

 acatctgacc tgtgcatcca ggagccgagg agtcaggttg taatacaggc caagcagacg   3796

 ggctttgagg gcatttagtc tcagaaaaaa aaaatgtaga aggatttcgg aattagaatt   3856

 ttgtgtattg tatctgtagt tttgtaataa actaacgaaa aataaaaaaa aaaaaa       3912




      <210> 347
      <211> 1340
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (706)..(1179)

      <400> 347
 tttcgtctgc tcagcacaca gcccctcagt gccttccctc ctcccccagg gctggggtgg     60

 gctggcgggg ccacccctgc tgatccatcc cttggcttct gggcccagct cccctgactg    120

 cacagagggg actgtggagc tgtgggctgg ggcctcatgg aggcatgtcc tccttcccag    180

 ccaaggtgct gggatcctga ctgtcacctg ccccaaatcc agcctgggcc ctgtgcaccc    240

 tgggatgggt cacaggaggc ctgagaacca ggtccaggct gcggtttggg tgaaggacaa    300

 agggacgtcc tcttctgctc gctttgcctg ttctgcttct tctgtttctt catctcgcct    360

 tcttttcagc tccccctggg cccagctccc tgtccagcac tgaagacctg aaatggacct    420

 tactcagccc tgcacagagc aggaaacttc agccgcagtc gctgcacagg gctggggtgc    480

 gtgatctcca gtggcagggt cgtgcaggag cagagctcac ggcagcctgc ggccggcgcc    540

 ccctcgcccg gagacagctg tcctcttgca gggtctgccg tgccggaggg aaggctgctg    600

 ttggagtctc ttaatggctt tgctctggtc gtgagtgcag aagggacgat attttatgca    660

 tcagcaacga tcgtggacta tctgggcttc catcagacgg atgta    atg cac cag     714
                                                      Met His Gln
                                                        1

 aac att tat gac tac atc cac gtg gac gac cgc cag gac ttc tgc cgg      762
 Asn Ile Tyr Asp Tyr Ile His Val Asp Asp Arg Gln Asp Phe Cys Arg
       5                  10                  15

 cag ctc cac tgg gcc atg gac cct ccc cag gtg gtg ttt ggg cag ccc      810
 Gln Leu His Trp Ala Met Asp Pro Pro Gln Val Val Phe Gly Gln Pro
  20                  25                  30                  35

 ccg ccc ttg gag aca gga gat gat gct atc ctg ggg agg ctg ctc agg      858
 Pro Pro Leu Glu Thr Gly Asp Asp Ala Ile Leu Gly Arg Leu Leu Arg
                  40                  45                  50

 gcc cag gag tgg ggc aca ggc acg ccc acc gag tac tcg gcc ttc ctg      906
 Ala Gln Glu Trp Gly Thr Gly Thr Pro Thr Glu Tyr Ser Ala Phe Leu
              55                  60                  65

 acc cgc tgc ttc atc tgc cgt gtg cgc tgc ctg ctg gac agc acc tcg      954
 Thr Arg Cys Phe Ile Cys Arg Val Arg Cys Leu Leu Asp Ser Thr Ser
          70                  75                  80

 ggc ttc ctg acg atg cag ttt caa gga aaa cta aaa ttc ctg ttt gga     1002
 Gly Phe Leu Thr Met Gln Phe Gln Gly Lys Leu Lys Phe Leu Phe Gly
      85                  90                  95

 cag aag aag aag gcg ccg tca gga gcc atg ctc ccg ccg cgg ctg tcg     1050
 Gln Lys Lys Lys Ala Pro Ser Gly Ala Met Leu Pro Pro Arg Leu Ser
 100                 105                 110                 115

 ctg ttc tgc att gcg gca ccc gtt ctc ctc ccc tcc gca gcg gag atg     1098
 Leu Phe Cys Ile Ala Ala Pro Val Leu Leu Pro Ser Ala Ala Glu Met
                 120                 125                 130

 aaa atg agg agc gcg ctc ctg agg gca aaa ccc aga gca gac acc gca     1146
 Lys Met Arg Ser Ala Leu Leu Arg Ala Lys Pro Arg Ala Asp Thr Ala
             135                 140                 145

 gcc acc gcg gat gca aaa tgc ggt ctt gac tga ccttgtca gagtccaggc     1197
 Ala Thr Ala Asp Ala Lys Cys Gly Leu Asp 
         150                 155

 tcccgaacta gtttgagatc tgggactcag cagcacccgg cacgctgccg tccctcccgt   1257

 tctttggcgc ctttgacggg cagcacatct tctgtattca cacccgtgcc ctccgtggga   1317

 gcaccaggac ccgccaatgt att                                           1340




      <210> 348
      <211> 1144
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (287)..(676)

      <400> 348
 ctagctccag ctaggttcat gagctggccc tactgctctc tcctttcccc ttttcctctt     60

 atcccattgc attagtctgg attcttgctt acagataacc aaaaccttag tcaatctgat    120

 ttaagcaaaa accagaattg ataggctcac ataactgaaa ttccagggta gaccctaagg    180

 ccgggctgga tgcagggact cagtcatctc actcgggcta ggtctctctc aatgcctagt    240

 ccctatttca tctgagttgg cttccctctc aggtgggctt tttctc   atg gag atc     295
                                                      Met Glu Ile
                                                        1

 ctc agc agc cca tgg aag gag agt ctg ttt ttc cca tca tct tgt aca      343
 Leu Ser Ser Pro Trp Lys Glu Ser Leu Phe Phe Pro Ser Ser Cys Thr
       5                  10                  15

 agt ccc cag gtt gag tct cat tgg cct gct ggc ccc atg ccc atc cct      391
 Ser Pro Gln Val Glu Ser His Trp Pro Ala Gly Pro Met Pro Ile Pro
  20                  25                  30                  35

 gaa caa tac tgc aat tgg tca cct gca gtc aca tgc cct gtg act gca      439
 Glu Gln Tyr Cys Asn Trp Ser Pro Ala Val Thr Cys Pro Val Thr Ala
                  40                  45                  50

 gga agg tgg gga tgg gct agt tac cca aag gaa agt cca ggt gct gtg      487
 Gly Arg Trp Gly Trp Ala Ser Tyr Pro Lys Glu Ser Pro Gly Ala Val
              55                  60                  65

 ccc aga agg gag aat gga tgt ggg gca gag caa acc gta gat gtc tac      535
 Pro Arg Arg Glu Asn Gly Cys Gly Ala Glu Gln Thr Val Asp Val Tyr
          70                  75                  80

 ctt acc cag cca gac aag act gca tgt aag aac cag gct tac ggg cca      583
 Leu Thr Gln Pro Asp Lys Thr Ala Cys Lys Asn Gln Ala Tyr Gly Pro
      85                  90                  95

 gcc cct ctc tgc agg ccc aca ctg tac act cct gaa atg cca ttc ctt      631
 Ala Pro Leu Cys Arg Pro Thr Leu Tyr Thr Pro Glu Met Pro Phe Leu
 100                 105                 110                 115

 agt ctg gcc aac cct cat tca ccc ttc caa tct cag ctt ata tag atg      679
 Ser Leu Ala Asn Pro His Ser Pro Phe Gln Ser Gln Leu Ile 
                 120                 125

 gctccccatg ctgcctagga actaccccac attgcactcc catctctgca tgctccctgg    739

 aggcagggag gaggttttgt ccacctctat atccccagtc tctggcccac atcagtgttt    799

 tcagtaagtg ttagtgtgtt agtggcatca cttccaactg atatacctcc ttggtactac    859

 ccttcccaga cttaggaggc catcttttgg acaatggtgt atggtgggaa agtgctccag    919

 caaggaggct ctccttccat cctaggaccc tgggccagtt gtttcaactc cggccctcat    979

 accccagact gtgctgatac gggtttcctt cctagcccac gagataggat caaattagat   1039

 gctgttgtga aaggcctttg acatgtacgg gtttgggggg gtgtttggat tagggttgaa   1099

 gcagcggatt agcattagga acttacagtt gtccagtggc atgat                   1144




      <210> 349
      <211> 933
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(781)

      <400> 349
 gcgtatcagt cggaattttg gggagccaac cgcgccgtct gtccctggca agccagcggc     60

 ggtttaaagg aggtggcggg aagcctgtgt gtgcttcaaa tcgtcaccct catggtcgct    120

 ccggtttttc acgactgaaa acaacatagc aaaataagcc aagatgtctg tggatcca      178                                                                 
 atg acc tac gag gcc cag ttc ttt ggc ttc acg cca caa acg tgc atg      226
 Met Thr Tyr Glu Ala Gln Phe Phe Gly Phe Thr Pro Gln Thr Cys Met
   1               5                  10                  15

 ctt cgg atc tac att gca ttt caa gac tac cta ttt gaa gtg atg cag      274
 Leu Arg Ile Tyr Ile Ala Phe Gln Asp Tyr Leu Phe Glu Val Met Gln
              20                  25                  30

 gcc gtt gaa cag gtt att ctg aag aag ctg gat ggc atc cca gac tgt      322
 Ala Val Glu Gln Val Ile Leu Lys Lys Leu Asp Gly Ile Pro Asp Cys
          35                  40                  45

 gac att agc cca gtg cag att cgc aaa tgc aca gag aag ttt ctt tgc      370
 Asp Ile Ser Pro Val Gln Ile Arg Lys Cys Thr Glu Lys Phe Leu Cys
      50                  55                  60

 ttc atg aaa gga cat ttt gat aac ctt ttt agc aaa atg gag caa ctg      418
 Phe Met Lys Gly His Phe Asp Asn Leu Phe Ser Lys Met Glu Gln Leu
  65                  70                  75                  80

 ttt ttg cag ctg att tta cgt att ccc tca aac atc ttg ctt cct gaa      466
 Phe Leu Gln Leu Ile Leu Arg Ile Pro Ser Asn Ile Leu Leu Pro Glu
                  85                  90                  95

 gat aaa tgt aag gag aca cct tat agt gag gaa gat ttt cag cat ctc      514
 Asp Lys Cys Lys Glu Thr Pro Tyr Ser Glu Glu Asp Phe Gln His Leu
             100                 105                 110

 cag aaa gaa att gaa cag tta cag gag aag tac aag act gaa tta tgt      562
 Gln Lys Glu Ile Glu Gln Leu Gln Glu Lys Tyr Lys Thr Glu Leu Cys
         115                 120                 125

 act aag cag gcc ctt ctt gca gaa tta gaa gag caa aaa att gtt cag      610
 Thr Lys Gln Ala Leu Leu Ala Glu Leu Glu Glu Gln Lys Ile Val Gln
     130                 135                 140

 gcc aaa ctc aaa cag acg ttg act ttc ttt gat gag ctt cat aat gtt      658
 Ala Lys Leu Lys Gln Thr Leu Thr Phe Phe Asp Glu Leu His Asn Val
 145                 150                 155                 160

 ggc aga gat cat ggg act agt gat ttt agg gag agt tta gta tcc ctg      706
 Gly Arg Asp His Gly Thr Ser Asp Phe Arg Glu Ser Leu Val Ser Leu
                 165                 170                 175

 gtt cag aac tcc aga aaa cta cag aac att aga gac aat gtg gaa aag      754
 Val Gln Asn Ser Arg Lys Leu Gln Asn Ile Arg Asp Asn Val Glu Lys
             180                 185                 190

 gaa tcg aaa cga ctg aaa ata tct taa ttgct cagtagtcaa aaggaggagc      806
 Glu Ser Lys Arg Leu Lys Ile Ser 
         195                 200

 ctgtcaaaaa gtagaatcat aaggactgtt caaaccataa ggactgttca aatcatacca    866

 gtgactgttc aaaccaacca tactttttat tagatttgct ttgtcaactc tttaaaaaaa    926

 aaaaaaa                                                              933




      <210> 350
      <211> 500
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(362)

      <400> 350
 gggacttgaa gactaggagg gaagaaacag cgaggtgagg agtaagg  atg act ttt      56
                                                      Met Thr Phe
                                                        1

 cgg gcc aca gat agt gaa ttt gac ctg aca aat att gaa gag tat gcc      104
 Arg Ala Thr Asp Ser Glu Phe Asp Leu Thr Asn Ile Glu Glu Tyr Ala
       5                  10                  15

 gaa aat tct gca ctt tca aga ctg aat aat ata aaa gcc aaa caa aga      152
 Glu Asn Ser Ala Leu Ser Arg Leu Asn Asn Ile Lys Ala Lys Gln Arg
  20                  25                  30                  35

 gtg agt tat gtg aca tcc aca gaa aat gaa tct gat aca caa atc cta      200
 Val Ser Tyr Val Thr Ser Thr Glu Asn Glu Ser Asp Thr Gln Ile Leu
                  40                  45                  50

 acg ttt agg cac att aca aaa gct cag gag aag aca aga aaa cga cag      248
 Thr Phe Arg His Ile Thr Lys Ala Gln Glu Lys Thr Arg Lys Arg Gln
              55                  60                  65

 cag cct ata aaa cta gag cct ttg gta agt tca aaa acc att gtt tta      296
 Gln Pro Ile Lys Leu Glu Pro Leu Val Ser Ser Lys Thr Ile Val Leu
          70                  75                  80

 gcc tct gta gcc aca gag gaa gtt gta aaa ttg ctt tgg agg ata gaa      344
 Ala Ser Val Ala Thr Glu Glu Val Val Lys Leu Leu Trp Arg Ile Glu
      85                  90                  95

 gtc atg tcc aga ctc tga actgac aaagaaggaa tgaaaagcta aaagataata      398
 Val Met Ser Arg Leu 
 100

 actgcttatg tagttgtaaa tacggtaaat atttattaaa caaatattaa gttctaggca    458

 ctggttaagt tgaaggatac agtggtgaac aaagttttca gg                       500




      <210> 351
      <211> 1111
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (408)..(593)

      <220>
      <221> misc_feature
      <222> (1)...(1111)
      <223> n = a,t,c or g

      <400> 351
 aaaaaccaag aagaaaaatt gaagagggcg ttaatttctc aagtaaatcg ttgaacgtca     60

 aatcagtcag gggagaaagt gctgattttg ttaaagcatc tttttaactt acagtgcgta    120

 ttgtaattgt caatcttaat gtaagaggac aggatctgtt tcttgagtgt gtattgaaaa    180

 ccaagaataa aattggatca caattgggct tataattatc aataaccagg cagaattaga    240

 aggtagacca atttggagct ccccacggtc atcctttatg gaaaacttta gaactatatt    300

 gtctgaaaag ttgtctcaat ttttcaagcc ttttgttagc attaatgctt ggttttccat    360

 agtaatgatg ggttcgttcc tctgcatatc ttctctttta tagacag  atg cat tcc     416
                                                      Met His Ser
                                                        1

 aga agc ccg ttc cat tgg aac agc acc ctg act atg cgg aat aca tct      464
 Arg Ser Pro Phe His Trp Asn Ser Thr Leu Thr Met Arg Asn Thr Ser
       5                  10                  15

 tcc atc caa tgg acc ttt gta cat tgg aaa agg ttg gcc tcc gtc aaa      512
 Ser Ile Gln Trp Thr Phe Val His Trp Lys Arg Leu Ala Ser Val Lys
  20                  25                  30                  35

 gaa cct cac cat tct agc cca cag ttg aga tgc cta agg ctc ttc cct      560
 Glu Pro His His Ser Ser Pro Gln Leu Arg Cys Leu Arg Leu Phe Pro
                  40                  45                  50

 cac tgc cta tgc tct atc aca agt tgg aca taa caatctta aattgtttct      611
 His Cys Leu Cys Ser Ile Thr Ser Trp Thr 
              55                  60

 ctatattttc attgctcctt tatttggata gaagaactct tgattctcta acgtctttcc    671

 tttgtaacat tcttccaaga ttgcagtgga atgttgaaat tctttggtaa tacttttgcg    731

 atgattctag ctttttacct gcaaaagcca tagcttctaa gagttagtga tttgattgac    791

 ttgagcgtta cctcctcttt ctttcggagg tgctaatgag agcagcagga aggaagaaga    851

 gaaaattaag tgtctgggaa gcctccagat tagcaataaa gatgtggctt cttagaattt    911

 gacttactct actgattagg ttttttcttg aatgcctgaa ggttttaaaa gntcatgcta    971

 aaattccacg ctgaaaatta cacttggaac actgtagatt gtgcacatta ttctgatgct   1031

 gattttccaa ctatttgcag caaaaccctg ggcagtgaaa tgcatccacg aggaagaaac   1091

 attacttcat attgtcttcc                                               1111




      <210> 352
      <211> 554
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (310)..(513)

      <400> 352
 ctccttgtat tcaatatgaa aataaattct agctgtgaaa tcagccattt gatgaacagg     60

 ccctcattcc tttggggaga agagatagtt agggatccca atctgggtcg ctaagggtgc    120

 tcattcctac tggattggta attatttcaa gaaatttttt aaggaatact ttttttattt    180

 tactttaagt tctggtgtca ggagaatagc aatgcctggg agtccaccac caccataatc    240

 tcctgtgatc ccacggagct gcagtcagaa gggagcaatg acaagaaata agtgctgagc    300

 agttgtcat    atg gtg ctg gaa gac atg cta ctt ttc cct gag ggc gga     348
              Met Val Leu Glu Asp Met Leu Leu Phe Pro Glu Gly Gly
                1               5                  10

 aga cag cct gat gac gga ggt aca atc aat gac atc tct gtg ctg gga      396
 Arg Gln Pro Asp Asp Gly Gly Thr Ile Asn Asp Ile Ser Val Leu Gly
      15                  20                  25

 gtg acc tgc ttg ggg gcc cag gct gat cat ttc aca cag aca ccc ctg      444
 Val Thr Cys Leu Gly Ala Gln Ala Asp His Phe Thr Gln Thr Pro Leu
  30                  35                  40                  45

 gat cct gga agc caa gtc ctg gtc tgg gta gac tgg gag tgg agg ttt      492
 Asp Pro Gly Ser Gln Val Leu Val Trp Val Asp Trp Glu Trp Arg Phe
                  50                  55                  60

 gac cac atg cag cag cat taa ag gcagcatctc atcacagcag ttgctgatta      545
 Asp His Met Gln Gln His 
              65

 tctgtttga                                                            554




      <210> 353
      <211> 811
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(643)

      <400> 353
 cttcaac  atg gcc gaa gca agt agc gcc aat cta ggc agc ggc tgt gag      49
          Met Ala Glu Ala Ser Ser Ala Asn Leu Gly Ser Gly Cys Glu
            1               5                  10

 gaa aaa agg cat gag ggg tcg tct tcg gaa tct gtg cca ccc ggc act       97
 Glu Lys Arg His Glu Gly Ser Ser Ser Glu Ser Val Pro Pro Gly Thr
  15                  20                  25                  30

 acc att tcg agg gtg aag ctc ctc gac acc atg gtg gac act ttt ctt      145
 Thr Ile Ser Arg Val Lys Leu Leu Asp Thr Met Val Asp Thr Phe Leu
                  35                  40                  45

 cag aag ctg gtc gcc gcc ggc agc tac cag aga ttc act gac tgc tat      193
 Gln Lys Leu Val Ala Ala Gly Ser Tyr Gln Arg Phe Thr Asp Cys Tyr
              50                  55                  60

 aag tgc ttc tac cag ttg cag cct gcg atg aca cag caa atc tat gac      241
 Lys Cys Phe Tyr Gln Leu Gln Pro Ala Met Thr Gln Gln Ile Tyr Asp
          65                  70                  75

 aag ttt ata gct cag ttg cag aca tct atc cgg gag gaa atc tct gac      289
 Lys Phe Ile Ala Gln Leu Gln Thr Ser Ile Arg Glu Glu Ile Ser Asp
      80                  85                  90

 atc aaa gag gag ggg aac cta gaa gct gtc ttg aat gcc ttg gat aaa      337
 Ile Lys Glu Glu Gly Asn Leu Glu Ala Val Leu Asn Ala Leu Asp Lys
  95                 100                 105                 110

 att gtg gaa gaa ggc aaa gtc cgc aaa gag cca gcc tgg cgc ccc agc      385
 Ile Val Glu Glu Gly Lys Val Arg Lys Glu Pro Ala Trp Arg Pro Ser
                 115                 120                 125

 ggg atc cca gag aag gat ctg cac agt gtt atg gca ccc tac ttc ctg      433
 Gly Ile Pro Glu Lys Asp Leu His Ser Val Met Ala Pro Tyr Phe Leu
             130                 135                 140

 cag caa cgg gac acc ctg cgg cgc cat gtg cag aaa cag gag gcc gag      481
 Gln Gln Arg Asp Thr Leu Arg Arg His Val Gln Lys Gln Glu Ala Glu
         145                 150                 155

 aac cag cag ctg gca gat gcc gtc ctg gca ggg cgg agg cag gtg gag      529
 Asn Gln Gln Leu Ala Asp Ala Val Leu Ala Gly Arg Arg Gln Val Glu
     160                 165                 170

 gag ctg cag cta cag gtc cag gcc cag cag cag gcc tgg cag gtg cga      577
 Glu Leu Gln Leu Gln Val Gln Ala Gln Gln Gln Ala Trp Gln Val Arg
 175                 180                 185                 190

 agc cca gcg gtg cag agt cca gca aag gtg cag cct ttg tgt cca agc      625
 Ser Pro Ala Val Gln Ser Pro Ala Lys Val Gln Pro Leu Cys Pro Ser
                 195                 200                 205

 agg agg gca gcg agg tag tgaaga gacccaggcg ctacctgtat caatggtggg      679
 Arg Arg Ala Ala Arg 
             210

 agccccagtc ccctacccgg atccctggag ccaggagggg aggtgtgtga gctcaatccg    739

 gactgtgacg gagttgggtg acacaatcgg gtttccagga ggctatcggg gctctaaggc    799

 cggctaaggt gc                                                        811




      <210> 354
      <211> 360
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(309)

      <400> 354
 ctaggtagga ggctgtttga gccaggcaga agactgtggg agcagatttg ggatgtgttt     60

 ggggagtcgg gtcgacagga cttgttt    atg gat tgg atg tgg aga gtg acg     111
                                  Met Asp Trp Met Trp Arg Val Thr
                                    1               5

 agg aga gga gag tta act tca tgt ctg tct gga gcc acg tac cag ttt      159
 Arg Arg Gly Glu Leu Thr Ser Cys Leu Ser Gly Ala Thr Tyr Gln Phe
      10                  15                  20

 ttt tat ggt gtc tca aca ccc cat gca ctt gcc acc tac ttg aga aaa      207
 Phe Tyr Gly Val Ser Thr Pro His Ala Leu Ala Thr Tyr Leu Arg Lys
  25                  30                  35                  40

 cta cta gac ctt aaa agt gag agt ttt aaa caa atg aat gtt tgt ttt      255
 Leu Leu Asp Leu Lys Ser Glu Ser Phe Lys Gln Met Asn Val Cys Phe
                  45                  50                  55

 gtt tta cat tta ccg tgg gaa att tta aat ata tac aga aat aga gta      303
 Val Leu His Leu Pro Trp Glu Ile Leu Asn Ile Tyr Arg Asn Arg Val
              60                  65                  70

 tca tag caagcctgca ttcatctgtc acccagctcc aaaaattata aactcatagc       359
 Ser 


 t                                                                    360




      <210> 355
      <211> 2369
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (109)..(2088)

      <400> 355
 tttcgtcttt gtgctccagt cgctcctaac gctccctggc ccggctgggg ccgcgcagtt     60

 agggcatctg aggcggggag aagcggcggg gagacgccgg ctgccagc atg tcg ctg     117
                                                      Met Ser Leu
                                                        1

 cct ccg gag aaa gcc tcc gag ctg aag cag ctc atc cac cag cag ctg      165
 Pro Pro Glu Lys Ala Ser Glu Leu Lys Gln Leu Ile His Gln Gln Leu
       5                  10                  15

 agc aag atg gat gtc cat ggt aga ata aga gaa atc ctt gct gag act      213
 Ser Lys Met Asp Val His Gly Arg Ile Arg Glu Ile Leu Ala Glu Thr
  20                  25                  30                  35

 ata cgg gaa gaa ttg gca cct gat caa cag cat tta tca aca gaa gat      261
 Ile Arg Glu Glu Leu Ala Pro Asp Gln Gln His Leu Ser Thr Glu Asp
                  40                  45                  50

 ttg atc aaa gcc ctt aga cgt cga gga atc att gac gat gtg atg aaa      309
 Leu Ile Lys Ala Leu Arg Arg Arg Gly Ile Ile Asp Asp Val Met Lys
              55                  60                  65

 gaa ctt aat ttt gtt act gac agt gtt gag caa gaa ctc cct tcc tct      357
 Glu Leu Asn Phe Val Thr Asp Ser Val Glu Gln Glu Leu Pro Ser Ser
          70                  75                  80

 cca aaa caa cct att tgt ttt gat aga caa tcg aca tta aaa aaa act      405
 Pro Lys Gln Pro Ile Cys Phe Asp Arg Gln Ser Thr Leu Lys Lys Thr
      85                  90                  95

 aat att gat cca aca cgg agg tat ctt tac ctt cag gtt ttg ggt gga      453
 Asn Ile Asp Pro Thr Arg Arg Tyr Leu Tyr Leu Gln Val Leu Gly Gly
 100                 105                 110                 115

 aaa gct ttc ttg gaa cat ctg caa gaa cct gag cct tta cct gga caa      501
 Lys Ala Phe Leu Glu His Leu Gln Glu Pro Glu Pro Leu Pro Gly Gln
                 120                 125                 130

 gtt tgt tca acg ttt act tta tgt tta cat tat cga aac caa cgt ttt      549
 Val Cys Ser Thr Phe Thr Leu Cys Leu His Tyr Arg Asn Gln Arg Phe
             135                 140                 145

 cgt tct aaa cct gtt cca tgt gcc tgt gaa cca gat ttt cat gat ggc      597
 Arg Ser Lys Pro Val Pro Cys Ala Cys Glu Pro Asp Phe His Asp Gly
         150                 155                 160

 ttt tta ctt gaa gta cac aga gaa agc ttg ggt gat gga act aga atg      645
 Phe Leu Leu Glu Val His Arg Glu Ser Leu Gly Asp Gly Thr Arg Met
     165                 170                 175

 gct gat tca aca aca atg tta tca ata agt gat cca att cat atg gtg      693
 Ala Asp Ser Thr Thr Met Leu Ser Ile Ser Asp Pro Ile His Met Val
 180                 185                 190                 195

 cta atc aaa aca gac ata ttt ggt gag acg act tta gta gca tca tat      741
 Leu Ile Lys Thr Asp Ile Phe Gly Glu Thr Thr Leu Val Ala Ser Tyr
                 200                 205                 210

 ttt ctg gaa tgg cga tcg gtt ttg ggc tca gaa aat gga gtg acc agt      789
 Phe Leu Glu Trp Arg Ser Val Leu Gly Ser Glu Asn Gly Val Thr Ser
             215                 220                 225

 ctg act gtg gaa ctt atg ggt gta ggc aca gaa tca aaa gtt tct gtg      837
 Leu Thr Val Glu Leu Met Gly Val Gly Thr Glu Ser Lys Val Ser Val
         230                 235                 240

 gga att tta aat ata aaa ctt gaa atg tat cca cca ctc aat caa acg      885
 Gly Ile Leu Asn Ile Lys Leu Glu Met Tyr Pro Pro Leu Asn Gln Thr
     245                 250                 255

 tta tct caa gaa gta gtg aac aca cag ctt gct ttg gaa cgt cag aaa      933
 Leu Ser Gln Glu Val Val Asn Thr Gln Leu Ala Leu Glu Arg Gln Lys
 260                 265                 270                 275

 act gca gag aaa gag cga tta ttt ctt gta tat gct aag cag tgg tgg      981
 Thr Ala Glu Lys Glu Arg Leu Phe Leu Val Tyr Ala Lys Gln Trp Trp
                 280                 285                 290

 aga gaa tat ttg caa att cga ccc tca cac aac tca cga ctg gtt aag     1029
 Arg Glu Tyr Leu Gln Ile Arg Pro Ser His Asn Ser Arg Leu Val Lys
             295                 300                 305

 att ttt gca cag gat gaa aat ggg ata aat aga cca gtc tgt tcc tat     1077
 Ile Phe Ala Gln Asp Glu Asn Gly Ile Asn Arg Pro Val Cys Ser Tyr
         310                 315                 320

 gtt aaa cca ctt cga gct gga cgg ctt ctt gat act cca agg caa gca     1125
 Val Lys Pro Leu Arg Ala Gly Arg Leu Leu Asp Thr Pro Arg Gln Ala
     325                 330                 335

 gca aga ttt gtt aat gtc ctt ggt tat gaa cga gcc cct gtt att gga     1173
 Ala Arg Phe Val Asn Val Leu Gly Tyr Glu Arg Ala Pro Val Ile Gly
 340                 345                 350                 355

 gga gga ggt aaa cag gag cag tgg tgc act ctg ctg gcc ttt ctc tgt     1221
 Gly Gly Gly Lys Gln Glu Gln Trp Cys Thr Leu Leu Ala Phe Leu Cys
                 360                 365                 370

 aga aac aag ggt gac tgt gaa gat cac gct aac ctt ctg tgc agc ctt     1269
 Arg Asn Lys Gly Asp Cys Glu Asp His Ala Asn Leu Leu Cys Ser Leu
             375                 380                 385

 ctt ctt gga tat gga tta gaa gcc ttt gtt tgt gtt ggg acc aag gca     1317
 Leu Leu Gly Tyr Gly Leu Glu Ala Phe Val Cys Val Gly Thr Lys Ala
         390                 395                 400

 aaa gga gta cct cat gca tgg gtt atg act tgt gga act gat ggg gcc     1365
 Lys Gly Val Pro His Ala Trp Val Met Thr Cys Gly Thr Asp Gly Ala
     405                 410                 415

 atc act ttt tgg gag agt tta aca gga cac agg tac atc cat aaa cct     1413
 Ile Thr Phe Trp Glu Ser Leu Thr Gly His Arg Tyr Ile His Lys Pro
 420                 425                 430                 435

 acc aat cct gat gaa cct cca gtt gct gaa cag ccc aaa cca ctg tac     1461
 Thr Asn Pro Asp Glu Pro Pro Val Ala Glu Gln Pro Lys Pro Leu Tyr
                 440                 445                 450

 cca tat cga aca att ggt tgt gtt ttc aac cat cag atg ttc ctg gga     1509
 Pro Tyr Arg Thr Ile Gly Cys Val Phe Asn His Gln Met Phe Leu Gly
             455                 460                 465

 aat tgt caa ccc tct gat gca gta gaa acc tgt gta ttt gat ttg aac     1557
 Asn Cys Gln Pro Ser Asp Ala Val Glu Thr Cys Val Phe Asp Leu Asn
         470                 475                 480

 gat gaa tcc aaa tgg aaa ccc atg agt gag gaa gca att aaa tct gtg     1605
 Asp Glu Ser Lys Trp Lys Pro Met Ser Glu Glu Ala Ile Lys Ser Val
     485                 490                 495

 tgt gct cct gga gct aca aca tcc ctt cct ccc ttt cca cct ctg tgt     1653
 Cys Ala Pro Gly Ala Thr Thr Ser Leu Pro Pro Phe Pro Pro Leu Cys
 500                 505                 510                 515

 gca tcc aca att gac gcg tca gta aca agt aat gaa att gaa atg cag     1701
 Ala Ser Thr Ile Asp Ala Ser Val Thr Ser Asn Glu Ile Glu Met Gln
                 520                 525                 530

 ctg agg ctc ctg gtg tca gaa cac agg aag gat ctt ggc ctc act act     1749
 Leu Arg Leu Leu Val Ser Glu His Arg Lys Asp Leu Gly Leu Thr Thr
             535                 540                 545

 gtt tgg gaa gac cag ctc tcc tac ctt tta tca cca gct ttg gct tct     1797
 Val Trp Glu Asp Gln Leu Ser Tyr Leu Leu Ser Pro Ala Leu Ala Ser
         550                 555                 560

 tat gaa ttt gag cgt aca aca agt ata tca gca ggc aat gaa gaa ttt     1845
 Tyr Glu Phe Glu Arg Thr Thr Ser Ile Ser Ala Gly Asn Glu Glu Phe
     565                 570                 575

 caa gat gcc ata aga agg gct gta cct gat ggt cac aca ttt aaa ggg     1893
 Gln Asp Ala Ile Arg Arg Ala Val Pro Asp Gly His Thr Phe Lys Gly
 580                 585                 590                 595

 ttc cca ata cat ttt gtg tat aga aat gca aga cgt gca ttt gcc aca     1941
 Phe Pro Ile His Phe Val Tyr Arg Asn Ala Arg Arg Ala Phe Ala Thr
                 600                 605                 610

 tgt ctt cga tct cct ttc tgt gaa gaa ata atc tgt tgc cgt gga gac     1989
 Cys Leu Arg Ser Pro Phe Cys Glu Glu Ile Ile Cys Cys Arg Gly Asp
             615                 620                 625

 caa gtg cga ctg gca gtt cgt gtc cga gta ttt act tac cct gaa tct     2037
 Gln Val Arg Leu Ala Val Arg Val Arg Val Phe Thr Tyr Pro Glu Ser
         630                 635                 640

 gca tgt gct gtt tgg atc atg ttt gct tgt aaa tat cgc tcg gta tta     2085
 Ala Cys Ala Val Trp Ile Met Phe Ala Cys Lys Tyr Arg Ser Val Leu
     645                 650                 655

 tag ggcc aatatttata taagatttat acctgtgttt aattggaatt ttacacattg     2142
 


 tacattactt agctatttag aggtttgtta ttttaaaatc acaatctggc ttgaatggca   2202

 tacttcaatt ttgtatatac ttgactggta atgtttaaaa aaaatcatgc attcctttaa   2262

 aaattaaggc tgaaaaactt gtataaatct ccctggaatt tagtataaat taagtgtata   2322

 ttctatttta ataaatgcta ctttgtttac agttaaaaaa aaaaaaa                 2369




      <210> 356
      <211> 1385
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (176)..(742)

      <400> 356
 ttgcccacgt cggccggacc actattcccg tggtgccccg cgggaggccg cgcaggcgca     60

 gtgagtcagt gccggtcggt cttgtgggct gaggggcagc ggcttaggct ccggcgtctg    120

 caggggtcgc cgagctaacc cgtggctagg cgagtggggc ggggcggccg gcacc atg     178
                                                              Met
                                                                1

 tcg agg cag gcg aac cgt ggc acc gag agc aag aaa atg agc tct gag      226
 Ser Arg Gln Ala Asn Arg Gly Thr Glu Ser Lys Lys Met Ser Ser Glu
               5                  10                  15

 ctc ttc acc ctg acc tat ggt gcc ctg gtc acc cag cta tgt aag gac      274
 Leu Phe Thr Leu Thr Tyr Gly Ala Leu Val Thr Gln Leu Cys Lys Asp
          20                  25                  30

 tat gaa aat gat gaa gat gtg aat aaa cag ctg gac aaa att ctc ttc      322
 Tyr Glu Asn Asp Glu Asp Val Asn Lys Gln Leu Asp Lys Ile Leu Phe
      35                  40                  45

 tct aac ttc ctt ccc agg ggc ttt aac att gga gtc cgg ctg att gaa      370
 Ser Asn Phe Leu Pro Arg Gly Phe Asn Ile Gly Val Arg Leu Ile Glu
  50                  55                  60                  65

 gat ttc ttg gct cgg tca aat gtt ggg agg tgc cat gac ttt cgg gaa      418
 Asp Phe Leu Ala Arg Ser Asn Val Gly Arg Cys His Asp Phe Arg Glu
                  70                  75                  80

 act gcg gat gtc att gcc aag gtg gcg ttc aag atg tac ttg ggc atc      466
 Thr Ala Asp Val Ile Ala Lys Val Ala Phe Lys Met Tyr Leu Gly Ile
              85                  90                  95

 act cca agc att act aat tgg agc cca gct ggt gat gaa ttc tcc ctc      514
 Thr Pro Ser Ile Thr Asn Trp Ser Pro Ala Gly Asp Glu Phe Ser Leu
         100                 105                 110

 att ttg gaa aat aac ccc ttg gtg gac ttt gtg gaa ctt cct gat aac      562
 Ile Leu Glu Asn Asn Pro Leu Val Asp Phe Val Glu Leu Pro Asp Asn
     115                 120                 125

 cac tca tcc ctt att tat tcc aat ctc ttg tgt ggg gtg ttg cgg gga      610
 His Ser Ser Leu Ile Tyr Ser Asn Leu Leu Cys Gly Val Leu Arg Gly
 130                 135                 140                 145

 gct ttg gag atg gtc cag atg gct gtg gag gcc aag ttt gtc cag gac      658
 Ala Leu Glu Met Val Gln Met Ala Val Glu Ala Lys Phe Val Gln Asp
                 150                 155                 160

 acc ctg aaa gga gac ggt gtg aca gaa atc cgg atg aga ttc atc agg      706
 Thr Leu Lys Gly Asp Gly Val Thr Glu Ile Arg Met Arg Phe Ile Arg
             165                 170                 175

 gcg att gag gac aat ctt cca gct gga gag gaa taa ccat ccctacaact      756
 Ala Ile Glu Asp Asn Leu Pro Ala Gly Glu Glu 
         180                 185

 cgaggatagc catcaggagc actgttggaa tcagcaggcc tctgtgctcc ctctgccctc    816

 cagaactcag tgactcttga acatggatgt tatatattct tataacctgt ttccattctc    876

 cattcaaata aagagcagac tgcgatatag tccatttacc ccatgtgtgc acattcagga    936

 gcgacagtct ctgcccccat tcccttgaga ggggctggat gtaatcacct ttggttggac    996

 tagaaagagc tcaaaccatt ttacattcct gtttgaattt ttccaaagca aaactcactt   1056

 tgaccccatt aagaggcaag cctggcacat ctatccctgg gcctttagaa agccatttgc   1116

 ctcaaatggc tatagggttg tggggtggag ggaggaaggg ctgggaggga gtggggagga   1176

 attgctagct gtagtgtgac acattgtagt gtttgccagg aaaggagcca gtcatgccgg   1236

 aaacactgac ttctgggaag ccacccaggt ctcattcctc cctgctgttg gaggcaacat   1296

 ctcctctttt tacagagggt acatcctttt ttcttacaaa ttcttcaata aagacacatt   1356

 cttgagtgaa atcccaaaaa aaaaaaaaa                                     1385




      <210> 357
      <211> 1027
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (271)..(813)

      <400> 357
 tcctcatctc ggtacccggg gatcaacaaa aaatccaacg ccagcacccc gcttgagaaa     60

 gccattaatg cagtgggcgg ctctcaaaag gtgcttgctg aaaaggtcgg cgtaacgcct    120

 caggccatca atatgcttaa aaagcgaggt ggcagccttc cagtaacaaa aatgcgtaaa    180

 tacgaagaag taaccggact tcctcgcgaa gttctatatc caggtatctt tgccgcctaa    240

 ccggcggctc taaccacgaa atggaaagca     atg cat tca ctt gcg tat caa     291
                                      Met His Ser Leu Ala Tyr Gln
                                        1               5

 cac aat acc gga ata cac ccg gga gcg atg ata aac cgc gct caa cct      339
 His Asn Thr Gly Ile His Pro Gly Ala Met Ile Asn Arg Ala Gln Pro
          10                  15                  20

 aag gcg gag cca ggt cac gac aaa atc cgc gat gcg gtc cgt gca tgg      387
 Lys Ala Glu Pro Gly His Asp Lys Ile Arg Asp Ala Val Arg Ala Trp
      25                  30                  35

 tcg tcg tcc ctg gac aat cag gac gta gtg tca gcg ctg atc atc aac      435
 Ser Ser Ser Leu Asp Asn Gln Asp Val Val Ser Ala Leu Ile Ile Asn
  40                  45                  50                  55

 gaa tac cgg gag cag ggc ggt acc gcc atc agc ttc cca gaa gac atc      483
 Glu Tyr Arg Glu Gln Gly Gly Thr Ala Ile Ser Phe Pro Glu Asp Ile
                  60                  65                  70

 agc agg gcg cgc cag aaa ctt ttt cgc ttt ctg gat aac cgc ttc gac      531
 Ser Arg Ala Arg Gln Lys Leu Phe Arg Phe Leu Asp Asn Arg Phe Asp
              75                  80                  85

 tcc gat cag tac cgc gag aac gtt aga gaa ctg acc ccg gca atc atg      579
 Ser Asp Gln Tyr Arg Glu Asn Val Arg Glu Leu Thr Pro Ala Ile Met
          90                  95                 100

 gct gtt ctt cct gtt gag ttt cgt aca cgc ctg gcg ccg cag aac gac      627
 Ala Val Leu Pro Val Glu Phe Arg Thr Arg Leu Ala Pro Gln Asn Asp
     105                 110                 115

 acc atg tcg ctg atc gca tct gcc atg aag gaa tgt tca gaa gca aag      675
 Thr Met Ser Leu Ile Ala Ser Ala Met Lys Glu Cys Ser Glu Ala Lys
 120                 125                 130                 135

 caa gcc gtt ctc ctg aac gcg cct gag cac cag aaa atg aag gag gta      723
 Gln Ala Val Leu Leu Asn Ala Pro Glu His Gln Lys Met Lys Glu Val
                 140                 145                 150

 agc gag ggc ata gcg tca ttg ttt cgc ctc atg ccg gag cag gta gga      771
 Ser Glu Gly Ile Ala Ser Leu Phe Arg Leu Met Pro Glu Gln Val Gly
             155                 160                 165

 ccg ctg atg acg atg gtt aca tcg atg ctg ggg gtt ata tga gaggcac      820
 Pro Leu Met Thr Met Val Thr Ser Met Leu Gly Val Ile 
         170                 175                 180

 aagaaaagaa aaagcccttg aagcggtaac ttcaaaggcc cttatcacac tgtgttacgg    880

 caagtaacgg gagtaagtat gtcaaacccc gctgaaataa tcaatttccc aaataaaacc    940

 gaacaacctg ggaggtaata agattaagct gggtaacggc atggccatcc cagtcacggc   1000

 gatgtccggg acggacaact gaattca                                       1027




      <210> 358
      <211> 599
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (165)..(431)

      <400> 358
 ctggcactgc tatctccagg gctgggttga ctcaagccag acagggggaa ggaattggtt     60

 ctgcaggaca gtgagagggt ctgtgtcccg gcacccctgg gacaacgctc ggctgcctgt    120

 gctcactgca tgagaaaact cagagggtgc attctccctc tggc atg gct gtg tct     176
                                                  Met Ala Val Ser
                                                    1

 ggg cgc ctt ggg ctg cgg cag ggg gca ggc ccc acg tgg gga agc ctc      224
 Gly Arg Leu Gly Leu Arg Gln Gly Ala Gly Pro Thr Trp Gly Ser Leu
   5                  10                  15                  20

 gtg ctt ggt cag ctt tct gtc tct ccc agg cca gtg aca act ggc ttc      272
 Val Leu Gly Gln Leu Ser Val Ser Pro Arg Pro Val Thr Thr Gly Phe
                  25                  30                  35

 ccg agg aag gag gtg agg tac cag gga ccc tgg gca gga cct ggt gtc      320
 Pro Arg Lys Glu Val Arg Tyr Gln Gly Pro Trp Ala Gly Pro Gly Val
              40                  45                  50

 ggg cag ggc ggt gcc agc act ggg gaa gga cag gga gcc ctc ccg gag      368
 Gly Gln Gly Gly Ala Ser Thr Gly Glu Gly Gln Gly Ala Leu Pro Glu
          55                  60                  65

 ccc cac cct gca cct gcc act ggg gtc agg gag tgt ctc ggg gtg cct      416
 Pro His Pro Ala Pro Ala Thr Gly Val Arg Glu Cys Leu Gly Val Pro
      70                  75                  80

 ttg ggg gca gca tga gctccaccag gggccccggc ccccacctca gcctatggcc      471
 Leu Gly Ala Ala 
  85

 cttccccatg gctaaggtca tgccttttct gaacagcttt ggccttgagt gcacacatct    531

 gtgccaggct cacggcatgt tcccgttgga tgtcagggtc cttgtccaaa ccaaactcac    591

 agctggcc                                                             599




      <210> 359
      <211> 2297
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (174)..(1619)

      <400> 359
 atggtccgag gggggcgggg ctgacgtcgc gctgggaatg ccctggccga gacactgagg     60

 cagggtagag agcgcttgcg ggcgccgggc ggagctgctg cggatcagga cccgggccga    120

 ttcccgatcc cgacccagat cctaacccgc gcccccgccc cgccgccgcc gcc   atg     176
                                                              Met
                                                                1

 tac gac gca gag cgc ggc tgg agc ttg tcc ttc gcg ggc tgc ggc ttc      224
 Tyr Asp Ala Glu Arg Gly Trp Ser Leu Ser Phe Ala Gly Cys Gly Phe
               5                  10                  15

 ctg ggc ttc tac cac gtc ggg gcg acc cgc tgc ctg agc gag cac gcc      272
 Leu Gly Phe Tyr His Val Gly Ala Thr Arg Cys Leu Ser Glu His Ala
          20                  25                  30

 ccg cac ctc ctc cgc gac gcg cgc atg ttg ttc ggc gct tcg gcc ggg      320
 Pro His Leu Leu Arg Asp Ala Arg Met Leu Phe Gly Ala Ser Ala Gly
      35                  40                  45

 gcg ttg cac tgc gtc ggc gtc ctc tcc ggt atc ccg ctg gag cag act      368
 Ala Leu His Cys Val Gly Val Leu Ser Gly Ile Pro Leu Glu Gln Thr
  50                  55                  60                  65

 ctg cag gtc ctc tca gat ctt gtg cgg aag gcc agg agt cgg aac att      416
 Leu Gln Val Leu Ser Asp Leu Val Arg Lys Ala Arg Ser Arg Asn Ile
                  70                  75                  80

 ggc atc ttc cat cca tcc ttc aac tta agc aag ttc ctc cga cag ggt      464
 Gly Ile Phe His Pro Ser Phe Asn Leu Ser Lys Phe Leu Arg Gln Gly
              85                  90                  95

 ctc tgc aaa tgc ctc ccg gcc aat gtc cac cag ctc atc tcc ggc aaa      512
 Leu Cys Lys Cys Leu Pro Ala Asn Val His Gln Leu Ile Ser Gly Lys
         100                 105                 110

 ata ggc atc tct ctt acc aga gtg tct gat ggg gaa aac gtt ctg gtg      560
 Ile Gly Ile Ser Leu Thr Arg Val Ser Asp Gly Glu Asn Val Leu Val
     115                 120                 125

 tct gac ttt cgg tcc aaa gac gaa gtc gtg gat gcc ttg gta tgt tcc      608
 Ser Asp Phe Arg Ser Lys Asp Glu Val Val Asp Ala Leu Val Cys Ser
 130                 135                 140                 145

 tgc ttc atc ccc ttc tac agt ggc ctt atc cct cct tcc ttc aga ggc      656
 Cys Phe Ile Pro Phe Tyr Ser Gly Leu Ile Pro Pro Ser Phe Arg Gly
                 150                 155                 160

 gtg cga tat gtg gat gga gga gtg agt gac aac gta ccc ttc att gat      704
 Val Arg Tyr Val Asp Gly Gly Val Ser Asp Asn Val Pro Phe Ile Asp
             165                 170                 175

 gcc aaa aca acc atc acc gtg tcc ccc ttc tat ggg gag tac gac atc      752
 Ala Lys Thr Thr Ile Thr Val Ser Pro Phe Tyr Gly Glu Tyr Asp Ile
         180                 185                 190

 tgc cct aaa gtc aag tcc acg aac ttt ctt cat gtg gac atc acc aag      800
 Cys Pro Lys Val Lys Ser Thr Asn Phe Leu His Val Asp Ile Thr Lys
     195                 200                 205

 ctc agt cta cgc ctc tgc aca ggg aac ctc tac ctt ctc tcg aga gct      848
 Leu Ser Leu Arg Leu Cys Thr Gly Asn Leu Tyr Leu Leu Ser Arg Ala
 210                 215                 220                 225

 ttt gtc ccc ccg gat ctc aag gtg ctg gga gag ata tgc ctt cga gga      896
 Phe Val Pro Pro Asp Leu Lys Val Leu Gly Glu Ile Cys Leu Arg Gly
                 230                 235                 240

 tat ttg gat gca ttc agg ttc ttg gaa gag aag ggc atc tgc aac agg      944
 Tyr Leu Asp Ala Phe Arg Phe Leu Glu Glu Lys Gly Ile Cys Asn Arg
             245                 250                 255

 ccc cag cca ggc ctg aag tca tcc tca gaa ggg atg gat cct gag gtc      992
 Pro Gln Pro Gly Leu Lys Ser Ser Ser Glu Gly Met Asp Pro Glu Val
         260                 265                 270

 gcc atg ccc agc tgg gca aac atg agt ctg gat tct tcc ccg gag tcg     1040
 Ala Met Pro Ser Trp Ala Asn Met Ser Leu Asp Ser Ser Pro Glu Ser
     275                 280                 285

 gct gcc ttg gct gtg agg ctg gag gga gat gag ctg cta gac cac ctg     1088
 Ala Ala Leu Ala Val Arg Leu Glu Gly Asp Glu Leu Leu Asp His Leu
 290                 295                 300                 305

 cgt ctc agc atc ctg ccc tgg gat gag agc atc ctg gac acc ctc tcg     1136
 Arg Leu Ser Ile Leu Pro Trp Asp Glu Ser Ile Leu Asp Thr Leu Ser
                 310                 315                 320

 ccc agg ctc gct aca gca ctg agt gaa gaa atg aaa gac aaa ggt gga     1184
 Pro Arg Leu Ala Thr Ala Leu Ser Glu Glu Met Lys Asp Lys Gly Gly
             325                 330                 335

 tac atg agc aag att tgc aac ttg cta ccc att agg ata atg tct tat     1232
 Tyr Met Ser Lys Ile Cys Asn Leu Leu Pro Ile Arg Ile Met Ser Tyr
         340                 345                 350

 gta atg ctg ccc tgt acc ctg cct gtg gaa tct gcc att gcg att gtc     1280
 Val Met Leu Pro Cys Thr Leu Pro Val Glu Ser Ala Ile Ala Ile Val
     355                 360                 365

 cag aga ctg gtg aca tgg ctt cca gat atg ccc gac gat gtc ctg tgg     1328
 Gln Arg Leu Val Thr Trp Leu Pro Asp Met Pro Asp Asp Val Leu Trp
 370                 375                 380                 385

 ttg cag tgg gtg acc tca cag gtg ttc act cga gtg ctg atg tgt ctg     1376
 Leu Gln Trp Val Thr Ser Gln Val Phe Thr Arg Val Leu Met Cys Leu
                 390                 395                 400

 ctc ccc gcc tcc agg tcc caa atg cca gtg agc agc caa cag gcc tcc     1424
 Leu Pro Ala Ser Arg Ser Gln Met Pro Val Ser Ser Gln Gln Ala Ser
             405                 410                 415

 cca tgc aca cct gag cag gac tgg ccc tgc tgg act ccc tgc tcc ccc     1472
 Pro Cys Thr Pro Glu Gln Asp Trp Pro Cys Trp Thr Pro Cys Ser Pro
         420                 425                 430

 gag ggc tgt cca gca gag acc aaa gca gag gcc acc ccg cgg tcc atc     1520
 Glu Gly Cys Pro Ala Glu Thr Lys Ala Glu Ala Thr Pro Arg Ser Ile
     435                 440                 445

 ctc agg tcc agc ctg aac ttc ttc ttg ggc aat aaa gta cct gct ggt     1568
 Leu Arg Ser Ser Leu Asn Phe Phe Leu Gly Asn Lys Val Pro Ala Gly
 450                 455                 460                 465

 gct gag ggg ctc tcc acc ttt ccc agt ttt tca cta gag aag agt ctg     1616
 Ala Glu Gly Leu Ser Thr Phe Pro Ser Phe Ser Leu Glu Lys Ser Leu
                 470                 475                 480

 tga gtca cttgaggagg cgagtctagc agattctttc agaggtgcta aagtttccca     1673
 


 tctttgtgca gctacctccg cattgctgtg tagtgacccc tgcctgtgac gtggaggatc   1733

 ccagcctctg agctgagttg gttttatgaa aagctaggaa gcaacctttc gcctgtgcag   1793

 cggtccagca cttaactcta atacatcagc atgcgttaat tcagctggtt gggaaatgac   1853

 accaggaagc ccagtgcaga gggtccctta ctgactgttt cgtggcccta ttaatggtca   1913

 gactgttcca gcatgaggtt cttaaaatga caggtgtttg gatgggtggg ggccttgtga   1973

 tggggggtag gctggcccat gtgtgatctt gtggggtgga gggaagagaa tagcatgatc   2033

 ccacttcccc atgctgtggg aaggggtgca gttcgtcccc aagaacgaca ctgcctgtca   2093

 ggtggtctgc aaagatgata accttgacta ctaaaaacgt ctccatggcg tgggtaacaa   2153

 gatgataatc tacttaattt tagaacacct ttttcaccta actaaaataa tgtttaaaga   2213

 gttttgtata aaaatgtaag gaagcgttgt tacctgttga attttgtatt atgtgaatca   2273

 gtgagatgtt agtagaataa gcct                                          2297




      <210> 360
      <211> 789
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (448)..(567)

      <400> 360
 ggaaaaccct ttttttaatt tcggattttt ttttttccat aaaggaaaac atcacttcct     60

 gaattactga cccaagccaa acagaaacaa taaccctcga gaaaataggt caacaatctg    120

 ttgtggggaa accacctcca tgtaacccac tggatacagt ccccttaatg tttttgctta    180

 taaattgtac cttttgcttc tgatttcttc tcccctgctg tttcctgccc atcagagagg    240

 cctgatacaa gcaagtttgt ttacatccct ggggaatctt ttacatcaaa cttttgggat    300

 ccaaatccat ctccttttaa atttcaatct cagcacctgc cagttatgca aatgccaaaa    360

 tgtgggtcat catatagtat atttgaaacc tttctgaaca tgtacaccac ccaatgctag    420

 aggctgactt ggaaaccggt gggtgca    atg ccc gag gct gtg gaa caa tca     471
                                  Met Pro Glu Ala Val Glu Gln Ser
                                    1               5

 gcc cat ctc ttt gtg acc tgg agc agt cag agg gcc ctc agt cac ccc      519
 Ala His Leu Phe Val Thr Trp Ser Ser Gln Arg Ala Leu Ser His Pro
      10                  15                  20

 gcc cca ttc ctc acc aga gaa aag aat cca ttt cta tgg aag ctc tga      567
 Ala Pro Phe Leu Thr Arg Glu Lys Asn Pro Phe Leu Trp Lys Leu 
  25                  30                  35

 cgtaacttca gtgttttcta caatactcct cctgccccgc cccattaaaa cagttctttt    627

 gttaagaaat agcctaatgg tccaactttg ctgtctgttc ttccaaatgt ttataataca    687

 cattatttat aaatatgtct gtttgggaag ctaagaacaa gctagttttt acaacacaaa    747

 tggaaataaa tgcaattatt ataaaaattc aaaaaaaaaa aa                       789




      <210> 361
      <211> 558
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (123)..(404)

      <400> 361
 cgctgcgtat tccgccgaga caagccgtca agcccaggag cttgagattt atccactccg     60

 gcgcaaaccc cggatgttcc gaggcactcg ctccatcttt ggaacacgcc aggaattgat    120

 tg   atg aca gct atg agg gac cct gcg agt agc cag tac aga tcc ttt     167
      Met Thr Ala Met Arg Asp Pro Ala Ser Ser Gln Tyr Arg Ser Phe
        1               5                  10                  15

 ctt ttc tgg agg atg ccc atc cca gaa ctg gat ctg tcg gag ctg gaa      215
 Leu Phe Trp Arg Met Pro Ile Pro Glu Leu Asp Leu Ser Glu Leu Glu
                  20                  25                  30

 cgc ctg ggt ctg tca cat aca gcc acc tac gag gtc aaa gac agc agc      263
 Arg Leu Gly Leu Ser His Thr Ala Thr Tyr Glu Val Lys Asp Ser Ser
              35                  40                  45

 ggt ggc aaa atg atc ggg caa gca act gca gca gac cag gag aaa aac      311
 Gly Gly Lys Met Ile Gly Gln Ala Thr Ala Ala Asp Gln Glu Lys Asn
          50                  55                  60

 cct gaa ggt gat ggc ctc ctt gag tac agc acc ttc aac ttc tgg aga      359
 Pro Glu Gly Asp Gly Leu Leu Glu Tyr Ser Thr Phe Asn Phe Trp Arg
      65                  70                  75

 gct ccc att gcc agc atc cac tcc ttc gaa ctg gac ttg ctc taa ggc      407
 Ala Pro Ile Ala Ser Ile His Ser Phe Glu Leu Asp Leu Leu 
  80                  85                  90

 caagacttct ctctcccatc accttgccct cattgtcttc cctctcaagc cccttccttt    467

 ccactccttt ccattttaat cttgttcttt ccctactgtg ttggttgtgc tgatgaatct    527

 ccaaagtgag gtctatggat tattatcatc g                                   558




      <210> 362
      <211> 513
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (82)..(255)

      <400> 362
 ggtagacagt ggcctcgaga ccctgcctgc ctgaggaggc ctcggttgga tgcgaaggag     60

 ctgcagcatc caggggacaa g  atg cca act ggc aag cag cta gct gac att     111
                          Met Pro Thr Gly Lys Gln Leu Ala Asp Ile
                            1               5                  10

 ggc tat aag acc ttc tct acc tcc atg atg ctt ctc act gtg tat ggg      159
 Gly Tyr Lys Thr Phe Ser Thr Ser Met Met Leu Leu Thr Val Tyr Gly
                  15                  20                  25

 ggg tac ctt tgc agt gtc cga gtc tac cac tat ttc cag tgg ggc agg      207
 Gly Tyr Leu Cys Ser Val Arg Val Tyr His Tyr Phe Gln Trp Gly Arg
              30                  35                  40

 gcc cag cgc cag gcc gca aaa aaa caa aag acc tca gga atc atg taa      255
 Ala Gln Arg Gln Ala Ala Lys Lys Gln Lys Thr Ser Gly Ile Met 
          45                  50                  55

 aactgggggg ctttttttcc tgaacaaaaa ggcccaaggc atgctgtgga aagacttccc    315

 ctgcccccat tttcaggtca acaggactag agcgttgatg gttttcaaac cctgttggaa    375

 aaaagtgccc atggtttttc tggttttgcc agtttgacag tttatggagg cttttgaatt    435

 gtaatagcaa tgtgagggtg agggacccct acagacatta aataatttgc tgtgtttgtg    495

 aaaaaaaaaa aaaaaaaa                                                  513




      <210> 363
      <211> 693
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(693)

      <400> 363
 cccacgcgtc cggaacctct gtgtctctca ttctttctct ctttctcatt ctctttcaat     60
                                                                 
 atg gaa ctt gaa aag cat gaa aaa aga agc tta tta aac aag aat tta      108
 Met Glu Leu Glu Lys His Glu Lys Arg Ser Leu Leu Asn Lys Asn Leu
   1               5                  10                  15

 gag gag aaa ctg acg gtc tct gct ggt ggt tct gaa gcc aaa cct ctg      156
 Glu Glu Lys Leu Thr Val Ser Ala Gly Gly Ser Glu Ala Lys Pro Leu
              20                  25                  30

 atc ttc aca ttt gtc ccc act gtc aga aga cta cca acc cat act cag      204
 Ile Phe Thr Phe Val Pro Thr Val Arg Arg Leu Pro Thr His Thr Gln
          35                  40                  45

 ttg gct gac acc tct aaa ttc ctt gtt aaa att cca gaa gaa tca agt      252
 Leu Ala Asp Thr Ser Lys Phe Leu Val Lys Ile Pro Glu Glu Ser Ser
      50                  55                  60

 gat aag agt cca gaa act gta aat agg tct aaa tcc aat gac tac ttg      300
 Asp Lys Ser Pro Glu Thr Val Asn Arg Ser Lys Ser Asn Asp Tyr Leu
  65                  70                  75                  80

 acc ttg aat gct ggg agc caa caa gag aga gac caa gcg aaa ttg act      348
 Thr Leu Asn Ala Gly Ser Gln Gln Glu Arg Asp Gln Ala Lys Leu Thr
                  85                  90                  95

 tgt cct tca gag gtc agt gga acg att tta caa gaa agg gaa ttc gaa      396
 Cys Pro Ser Glu Val Ser Gly Thr Ile Leu Gln Glu Arg Glu Phe Glu
             100                 105                 110

 gca aac aaa ctt caa ggg atg cag caa agt gac ctc ttc aaa gct gaa      444
 Ala Asn Lys Leu Gln Gly Met Gln Gln Ser Asp Leu Phe Lys Ala Glu
         115                 120                 125

 tat gtc ctt att gtg gac tcc gaa ggg gaa gat gag gct gca agc aga      492
 Tyr Val Leu Ile Val Asp Ser Glu Gly Glu Asp Glu Ala Ala Ser Arg
     130                 135                 140

 aaa gtt gaa caa ggc ccc cca ggg ggg att ggc acc gca gct gtc cgg      540
 Lys Val Glu Gln Gly Pro Pro Gly Gly Ile Gly Thr Ala Ala Val Arg
 145                 150                 155                 160

 ccc aag tct cta gct atc tcg tcc agt ctg gtc tct gat gta gtg cgt      588
 Pro Lys Ser Leu Ala Ile Ser Ser Ser Leu Val Ser Asp Val Val Arg
                 165                 170                 175

 ccc aaa aca cag ggg act gat ctc aag acc tca tca cat cct gaa atg      636
 Pro Lys Thr Gln Gly Thr Asp Leu Lys Thr Ser Ser His Pro Glu Met
             180                 185                 190

 ctt cat ggg atg gcc cct cag caa aag cat ggg cag ctc ttc tcc att      684
 Leu His Gly Met Ala Pro Gln Gln Lys His Gly Gln Leu Phe Ser Ile
         195                 200                 205

 ttg acc tag                                                          693
 Leu Thr 
     210





      <210> 364
      <211> 845
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(443)

      <400> 364
 acgactgcgt cgtgctatga ccggactttt tcttgaaagg ggatgacagc   atg gga      56
                                                          Met Gly
                                                            1

 ggc aat ggc tcc aca tgt aaa ccc gac act gaa aga caa ggc act ctc      104
 Gly Asn Gly Ser Thr Cys Lys Pro Asp Thr Glu Arg Gln Gly Thr Leu
           5                  10                  15

 tcc aca gca gcc cca aca act agc cct gca ccc tgt ctc tct aac cac      152
 Ser Thr Ala Ala Pro Thr Thr Ser Pro Ala Pro Cys Leu Ser Asn His
      20                  25                  30

 cac aac aaa aaa cat tta atc ctt gcc ttt tgt gct ggg gtt cta ctg      200
 His Asn Lys Lys His Leu Ile Leu Ala Phe Cys Ala Gly Val Leu Leu
  35                  40                  45                  50

 aca ctg ctg ctg ata gcc ttt atc ttc ctc atc ata aag agc tac aga      248
 Thr Leu Leu Leu Ile Ala Phe Ile Phe Leu Ile Ile Lys Ser Tyr Arg
                  55                  60                  65

 aaa tat cac tcc aag ccc cag gcc cca gat cct cac tca gat cct cca      296
 Lys Tyr His Ser Lys Pro Gln Ala Pro Asp Pro His Ser Asp Pro Pro
              70                  75                  80

 gcc aag ctt tca tcc atc cca ggg gaa tca ctt acc tat gcc agc aca      344
 Ala Lys Leu Ser Ser Ile Pro Gly Glu Ser Leu Thr Tyr Ala Ser Thr
          85                  90                  95

 act ttc aaa ctc tca gaa gaa aag agc aat cac ttg gct gag aac cat      392
 Thr Phe Lys Leu Ser Glu Glu Lys Ser Asn His Leu Ala Glu Asn His
     100                 105                 110

 tct gca gac ttt gac ccc att gtc tat gct caa att aaa gta aca aac      440
 Ser Ala Asp Phe Asp Pro Ile Val Tyr Ala Gln Ile Lys Val Thr Asn
 115                 120                 125                 130

 taa ctca gcttttccaa tgaggcttga atccatttcc tctcatctca gccctatctt      497
 


 cacacatcac tttcactttt ttacaaattt tggaccacca cctgtgtgaa actgcagtcg    557

 gagttgttta gatgtgatct ggcaatgcta tccagcatct ttggagacca atggtcagtc    617

 ttttcctggc cagaggaaag attgatggcc ctcccacttg aactgacagc ctgtgagccc    677

 cttgggggca tagactgcct tccttggacc cttccaaagt gtgtggtaca gagctcagtg    737

 cacagagtat tcacccagca tcatgaatca acttgggagg agtcaaccaa atgaacaatc    797

 taccaaaaat ttcaaataaa gtcaaacccc ccacaaaaaa aaaaaaaa                 845




      <210> 365
      <211> 1317
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(804)

      <400> 365
 gaagaattag cagcaaaagt ggttcag    atg ttt tat gtg gct gag cca aag      51
                                  Met Phe Tyr Val Ala Glu Pro Lys
                                    1               5

 caa gtg ccc cat att ctc tgt agt cct tct atg aag aat att aat cct       99
 Gln Val Pro His Ile Leu Cys Ser Pro Ser Met Lys Asn Ile Asn Pro
      10                  15                  20

 tta act gcc atg agc tat cta agg aag ctg gat act tct ggg ttt tca      147
 Leu Thr Ala Met Ser Tyr Leu Arg Lys Leu Asp Thr Ser Gly Phe Ser
  25                  30                  35                  40

 tcg atc tta gtg aca ttg acc aag gca gca gtg gct ctg aaa atg gga      195
 Ser Ile Leu Val Thr Leu Thr Lys Ala Ala Val Ala Leu Lys Met Gly
                  45                  50                  55

 gat ctt gac atg cac aga aat gaa atg aaa agc cat tca gag atg aag      243
 Asp Leu Asp Met His Arg Asn Glu Met Lys Ser His Ser Glu Met Lys
              60                  65                  70

 ttg gta tgt ggc ttc att ctg gaa cct cgg ctg ttg att caa cag aga      291
 Leu Val Cys Gly Phe Ile Leu Glu Pro Arg Leu Leu Ile Gln Gln Arg
          75                  80                  85

 aag gga cag att gtt cca acc gag ctt gca ctt cac ttg aag gaa act      339
 Lys Gly Gln Ile Val Pro Thr Glu Leu Ala Leu His Leu Lys Glu Thr
      90                  95                 100

 cag cct gga ttg ctt gtg gct tca gtt ctg ggc ttg cag aag aac aac      387
 Gln Pro Gly Leu Leu Val Ala Ser Val Leu Gly Leu Gln Lys Asn Asn
 105                 110                 115                 120

 aaa att gga att gaa gaa gca gat tcc ttt ttt aag gtg ctt tgt gct      435
 Lys Ile Gly Ile Glu Glu Ala Asp Ser Phe Phe Lys Val Leu Cys Ala
                 125                 130                 135

 aag gat gaa gat aca att cct cag ctc ttg gta gac ttt tgg gaa gct      483
 Lys Asp Glu Asp Thr Ile Pro Gln Leu Leu Val Asp Phe Trp Glu Ala
             140                 145                 150

 cag cta gtg gca tgt ctc cca gat gtg gta ctt cag gaa ctc ttt ttc      531
 Gln Leu Val Ala Cys Leu Pro Asp Val Val Leu Gln Glu Leu Phe Phe
         155                 160                 165

 aaa ctc aca tca cag tac atc tgg aga ttg tct aag agg cag cct cct      579
 Lys Leu Thr Ser Gln Tyr Ile Trp Arg Leu Ser Lys Arg Gln Pro Pro
     170                 175                 180

 gac acc aca cca ttg cga aca tcg gag gat ctg ata aat gcc tgt agt      627
 Asp Thr Thr Pro Leu Arg Thr Ser Glu Asp Leu Ile Asn Ala Cys Ser
 185                 190                 195                 200

 cat tat ggc tta att tat cca tgg gtt cat gtc gta ata tca tct gat      675
 His Tyr Gly Leu Ile Tyr Pro Trp Val His Val Val Ile Ser Ser Asp
                 205                 210                 215

 tct tta gct gat aaa aat tat aca gaa gat ctt tca aaa tta cag ctt      723
 Ser Leu Ala Asp Lys Asn Tyr Thr Glu Asp Leu Ser Lys Leu Gln Leu
             220                 225                 230

 cca tta ttc cgt tct tgg agc cac ttt cag aag aca cta ttg ccg gcc      771
 Pro Leu Phe Arg Ser Trp Ser His Phe Gln Lys Thr Leu Leu Pro Ala
         235                 240                 245

 tca gtg tcc atg ttc tgt gtc gta cac gct tga aagagtat gaacagtgca      822
 Ser Val Ser Met Phe Cys Val Val His Ala 
     250                 255

 tagacatact gttagagaga tgcccggagg cagtcattcc atatgctaat catgaactga    882

 aagaagagaa ccggatagac tctgtggtgg aaaaaactgt tgcctgaact ttgtcagaga    942

 ataaaatgtg gtggagagaa gtatcaactc tacctgtcat cattaaaagc ttaattttca   1002

 cgggaactgt ggaagctagc agacagtacc actacattat aaatgaggaa cctaggactt   1062

 ggaagattaa gtgactttct taaagccact cgaaacattg tcaattgttg ctgtggaact   1122

 agaactgaag gatttcatga atgttctccc agaagatggt actgcaacat ttttcttgcc   1182

 atatcttctc tattgcagtc gaaagaaacc attgacttaa aggtatcatt tgaaaaatac   1242

 cataatggca tttgagactg aatttctaaa aattgaatgc caaagtacaa gtagaggagt   1302

 tttttatttt atata                                                    1317




      <210> 366
      <211> 2258
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (336)..(1649)

      <400> 366
 gcacgagccg ccccgaggtt tctaaatcca gacattcccg tttggctgag cactctaggc     60

 ctacatccat gaagctagga gagcgacact caaagactgc actattgaga gaagctaacg    120

 ttaaaggcag tgaatatatt cgggagtcca gctccggaac ccgggagctc ttttagtggg    180

 aggggcggcg ctgatggcgc ttctggcctc cgaatgctag ggggcgctgt gatcgccggg    240

 cggcctcttg ggcgctggga gtccaccgcg caagcgcatc ctggcctttc ttcagtcccc    300

 acgtgcgatc cttcccggca actttttcga gaaaa   atg ccc aaa ttc aag gcg     353
                                          Met Pro Lys Phe Lys Ala
                                            1               5

 gcc cgt ggg gtg ggg ggt cag gaa aaa cat gcg ccc ctg gcc gat cag      401
 Ala Arg Gly Val Gly Gly Gln Glu Lys His Ala Pro Leu Ala Asp Gln
              10                  15                  20

 atc ctg gct ggg aat gcg gtg cgg gcg ggg gtc cgg gag aag cgg cgg      449
 Ile Leu Ala Gly Asn Ala Val Arg Ala Gly Val Arg Glu Lys Arg Arg
          25                  30                  35

 ggt cgc ggg aca gga gaa gcg gag gaa gag tat gtg ggg ccc cgg ctg      497
 Gly Arg Gly Thr Gly Glu Ala Glu Glu Glu Tyr Val Gly Pro Arg Leu
      40                  45                  50

 agc cga cgg att ttg cag caa gca cgg cag caa cag gag gaa ctc gag      545
 Ser Arg Arg Ile Leu Gln Gln Ala Arg Gln Gln Gln Glu Glu Leu Glu
  55                  60                  65                  70

 gcc gag cat ggg act ggg gac aag ccc gcg gcg ccg cgg gaa cgc acc      593
 Ala Glu His Gly Thr Gly Asp Lys Pro Ala Ala Pro Arg Glu Arg Thr
                  75                  80                  85

 acg cgg ctg ggt cca aga atg cct cag gat gga tca gat gac gag gac      641
 Thr Arg Leu Gly Pro Arg Met Pro Gln Asp Gly Ser Asp Asp Glu Asp
              90                  95                 100

 gag gag tgg ccc acc ctg gag aag gct gcc aca atg aca gca gcg ggc      689
 Glu Glu Trp Pro Thr Leu Glu Lys Ala Ala Thr Met Thr Ala Ala Gly
         105                 110                 115

 cat cat gca gag gtg gtt gtg gac cct gag gat gag cgt gcc ata gag      737
 His His Ala Glu Val Val Val Asp Pro Glu Asp Glu Arg Ala Ile Glu
     120                 125                 130

 atg ttc atg aac aag aac cct cct gcc agg cgc acc ctg gct gac atc      785
 Met Phe Met Asn Lys Asn Pro Pro Ala Arg Arg Thr Leu Ala Asp Ile
 135                 140                 145                 150

 atc atg gag aag ctg act gag aag cag aca gag gtt gag aca gtc atg      833
 Ile Met Glu Lys Leu Thr Glu Lys Gln Thr Glu Val Glu Thr Val Met
                 155                 160                 165

 tca gag gtg tcg ggc ttc cct atg ccc cag ctg gac ccc cgg gtc cta      881
 Ser Glu Val Ser Gly Phe Pro Met Pro Gln Leu Asp Pro Arg Val Leu
             170                 175                 180

 gaa gtg tac agg ggg gtc cgg gag gta tta tct aag tac cgc agt gga      929
 Glu Val Tyr Arg Gly Val Arg Glu Val Leu Ser Lys Tyr Arg Ser Gly
         185                 190                 195

 aaa ctg ccc aag gca ttt aag atc atc cct gca ctc tcc aac tgg gag      977
 Lys Leu Pro Lys Ala Phe Lys Ile Ile Pro Ala Leu Ser Asn Trp Glu
     200                 205                 210

 caa atc ctc tac gtc aca gag ccg gag gcc tgg act gca gct gcc atg     1025
 Gln Ile Leu Tyr Val Thr Glu Pro Glu Ala Trp Thr Ala Ala Ala Met
 215                 220                 225                 230

 tac cag gcc acc agg att ttt gcc tct aac ctg aag gaa cgc atg gcc     1073
 Tyr Gln Ala Thr Arg Ile Phe Ala Ser Asn Leu Lys Glu Arg Met Ala
                 235                 240                 245

 cag cgc ttc tac aac ctt gtc ctg ctc cct cga gta cga gat gac gtt     1121
 Gln Arg Phe Tyr Asn Leu Val Leu Leu Pro Arg Val Arg Asp Asp Val
             250                 255                 260

 gct gaa tac aaa cga ctc aac ttc cat ctc tac atg gct ctc aag aag     1169
 Ala Glu Tyr Lys Arg Leu Asn Phe His Leu Tyr Met Ala Leu Lys Lys
         265                 270                 275

 gcc ctt ttc aaa cct gga gcc tgg ttc aaa ggg atc ctg att cca ctg     1217
 Ala Leu Phe Lys Pro Gly Ala Trp Phe Lys Gly Ile Leu Ile Pro Leu
     280                 285                 290

 tgc gag tct ggc act tgt acc ctc cgg gaa gcc atc att gtg ggt agc     1265
 Cys Glu Ser Gly Thr Cys Thr Leu Arg Glu Ala Ile Ile Val Gly Ser
 295                 300                 305                 310

 atc atc acc aag tgc tcc atc cct gtg ttg cac tcc agt gcg gcc atg     1313
 Ile Ile Thr Lys Cys Ser Ile Pro Val Leu His Ser Ser Ala Ala Met
                 315                 320                 325

 ctg aaa att gct gag atg gaa tac agc ggt gcc aac agc atc ttc ctg     1361
 Leu Lys Ile Ala Glu Met Glu Tyr Ser Gly Ala Asn Ser Ile Phe Leu
             330                 335                 340

 cga ctg ctg ctg gat aag aag tat gca ctg cct tac cgg gtg ctg gat     1409
 Arg Leu Leu Leu Asp Lys Lys Tyr Ala Leu Pro Tyr Arg Val Leu Asp
         345                 350                 355

 gcc cta gtc ttc cac ttc ctg ggg ttc cgg aca gag aag cgt gaa ctg     1457
 Ala Leu Val Phe His Phe Leu Gly Phe Arg Thr Glu Lys Arg Glu Leu
     360                 365                 370

 cct gtg ctg tgg cac cag tgc ctc ctg act ttg gtc cag cgc tac aag     1505
 Pro Val Leu Trp His Gln Cys Leu Leu Thr Leu Val Gln Arg Tyr Lys
 375                 380                 385                 390

 gcc gac ttg gcc aca gac cag aaa gag gcc ctc tta gaa ctg ctc cgg     1553
 Ala Asp Leu Ala Thr Asp Gln Lys Glu Ala Leu Leu Glu Leu Leu Arg
                 395                 400                 405

 ctg cag ccc cat cca cag cta tcg ccc gaa atc agg cgt gag ctt cag     1601
 Leu Gln Pro His Pro Gln Leu Ser Pro Glu Ile Arg Arg Glu Leu Gln
             410                 415                 420

 agt gca gtc ccc cgc gat gtg gaa gat gtt ccc atc acc gtg gag tga     1649
 Ser Ala Val Pro Arg Asp Val Glu Asp Val Pro Ile Thr Val Glu 
         425                 430                 435

 ggaaaacagt cagctgtcct ggccaaaggg gtttggaagg acaccaagac ccccgttggt   1709

 gactgaagat gacactgagc tttaatggct gaagacccag atcagggcag tgacagatca   1769

 cagggacatc tgtggctccc agtccaggac aggaaggact gagggtctgg ctggttccct   1829

 cttccattct aggcccttat ccacagtgac ctgacacaat agccatagaa aaagtactca   1889

 caccaagccc cagctgggga ctgggaatgc tagcatatgg tatctcaagt tggctctcag   1949

 aactaaacag ggataagggc ctagaatgga agagggaacc agccagaccc tcagtccttc   2009

 ctgtcctgga ctgggagcca cagatgtccc tgtgatctgt cactgccctg atctgggtct   2069

 tcagccatta aagctcagtg tcatcttcag tcaccaacgg gggtcttggt gtccttccaa   2129

 acccctttgg ccaggacagc tgactgtttt cctcactcca cggtgatggg aacatcttcc   2189

 acatcgcggg ggactgcact ctgaagctca agcctgattt cgggcgatag ctgtggatgg   2249

 ggcttgcgc                                                           2258




      <210> 367
      <211> 606
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (271)..(528)

      <400> 367
 atcatgatct tcgagatgat cctgagcatg gtgctgtgct gtggcatccg gaacagctcc     60

 gtgtactgag gccccgcagc tctggccaca gggacctctg cagtgccccc taagtgaccc    120

 ggacacttcc gagggggcca tcaccgcctg tgtatataac gtttccggta ttactctgct    180

 acacgtagcc tttttacttt tggggttttg tttttgttct gaactttcct gttacctttt    240

 cagggctgac gtcacatgta ggtggcgtgt     atg agt gga gac ggg cct ggg     291
                                      Met Ser Gly Asp Gly Pro Gly
                                        1               5

 tct tgg gga ctg gag ggc agg ggt cct tct gcc ctg ggg tcc cag ggt      339
 Ser Trp Gly Leu Glu Gly Arg Gly Pro Ser Ala Leu Gly Ser Gln Gly
          10                  15                  20

 gct ctg cct gct cag cca ggc ctc tcc tgg gag cca ctc gcc cag aga      387
 Ala Leu Pro Ala Gln Pro Gly Leu Ser Trp Glu Pro Leu Ala Gln Arg
      25                  30                  35

 ctc agc ttg gcc aac ttg ggg ggc tgt gta cac cca gcc cgc ccg tcc      435
 Leu Ser Leu Ala Asn Leu Gly Gly Cys Val His Pro Ala Arg Pro Ser
  40                  45                  50                  55

 tgt ggg ctg cac agc tca cct tgt tcc ctc ctg ccc cgg gtc gag agc      483
 Cys Gly Leu His Ser Ser Pro Cys Ser Leu Leu Pro Arg Val Glu Ser
                  60                  65                  70

 cga gtc tgt ggg cac tct ctg gct tca tgc acc tgt tct ttt taa cac      531
 Arg Val Cys Gly His Ser Leu Ala Ser Cys Thr Cys Ser Phe 
              75                  80                  85

 gtcgccttca actgtaatca caacatcctg actccgtcat ttaataaaga aggaacatca    591

 tgcatgctaa aaaaa                                                     606




      <210> 368
      <211> 812
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (109)..(615)

      <400> 368
 ttactactac tactaaattt ccggccgcgt cgacggagag ctgtgtcacc atgtgggtcc     60

 cggttgtctt cctcaccctg tccgtgacgt ggattggtga gaggggcc atg gtt ggg     117
                                                      Met Val Gly
                                                        1

 ggg atg cag gag agg gag cca gcc ctg act gtc aag ctg agg ctc ttt      165
 Gly Met Gln Glu Arg Glu Pro Ala Leu Thr Val Lys Leu Arg Leu Phe
       5                  10                  15

 ccc ccc aaa ccc agc acc cca gcc cag aca ggg agc tgg gct ctt ttc      213
 Pro Pro Lys Pro Ser Thr Pro Ala Gln Thr Gly Ser Trp Ala Leu Phe
  20                  25                  30                  35

 tgt ctc tcc cag ccc cac tcc aag ccc ata ccc cca gcc cct cca tat      261
 Cys Leu Ser Gln Pro His Ser Lys Pro Ile Pro Pro Ala Pro Pro Tyr
                  40                  45                  50

 tgc aac agt cct cac tcc cac acc agg tcc ccg ctc cct ccc act tac      309
 Cys Asn Ser Pro His Ser His Thr Arg Ser Pro Leu Pro Pro Thr Tyr
              55                  60                  65

 ccc aga act ttc tcc cca ttg ccc agc caa ctc cct gct ccc agc tgc      357
 Pro Arg Thr Phe Ser Pro Leu Pro Ser Gln Leu Pro Ala Pro Ser Cys
          70                  75                  80

 ttt act aaa ggg gaa gtt cct ggg cat ctc cgt gtt tct ctt tgt ggg      405
 Phe Thr Lys Gly Glu Val Pro Gly His Leu Arg Val Ser Leu Cys Gly
      85                  90                  95

 gct caa aac ctc caa gga cct ctc tca atg cca ttg gtt cct tgg acc      453
 Ala Gln Asn Leu Gln Gly Pro Leu Ser Met Pro Leu Val Pro Trp Thr
 100                 105                 110                 115

 gta tca ctg gtc cac ctc ctg agc ccc tca atc cta tca cag tct act      501
 Val Ser Leu Val His Leu Leu Ser Pro Ser Ile Leu Ser Gln Ser Thr
                 120                 125                 130

 gac ttt tcc cat tca gct gtg agt gtc caa ccc tat ccc aga gac ctt      549
 Asp Phe Ser His Ser Ala Val Ser Val Gln Pro Tyr Pro Arg Asp Leu
             135                 140                 145

 gat gct tgg cct ccc aat ctt gcc cta gga tac cca gat gcc aac cag      597
 Asp Ala Trp Pro Pro Asn Leu Ala Leu Gly Tyr Pro Asp Ala Asn Gln
         150                 155                 160

 aca cct cct tct tcc tag ccaggc tatctggcct gagacaacaa atgggtccct      651
 Thr Pro Pro Ser Ser 
     165

 cagtctggca atgggactct gagaactcct cattccctga ctcttagccc cagactcttc    711

 attcagtggc ccacattttc cttaggaaaa acatgagcat ccccagccac aactgccagc    771

 tctctgattc cccaaatctg catccttttc aaaacctaaa a                        812




      <210> 369
      <211> 2419
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (518)..(1690)

      <400> 369
 ccgggcacac accttggccg tttatgtata cagaagtggg gtgccgggcg ggaagggcgc     60

 ggggaatgag ggaacctaga gcccgatgac gtcgttcagc tcgaggtccg cgttggggcg    120

 ccagcgggcc tgggggggct gcgtcccggg gcggggttcc gcgtcgggct tggcggcagc    180

 cgcctccggg cgcgccgcgt ccatgacgcc cagcaccgcg tccaggcaga agcggaatca    240

 ccgcccagtc cccaggcaga gagggttttg gcacaggccc ctcccaggct ttcttatccc    300

 ccaaaagttt gcctctagga gttaaaggac tagaaagcag tggtggaaaa gctgaggccc    360

 ctctgggcgg agtcccggtg cgcacggacg tggctcgagt ttcctctgct ctccgctctc    420

 gcccgctagc tctcctccct tccgctcctg cttctctccg ggtctcccgc tccagctcca    480

 gccccacccg gccggtcccg cacggctccg ggtagcc atg gag gac ccc acg ctc     535
                                          Met Glu Asp Pro Thr Leu
                                            1               5

 tat att gtc gag cgg ccg ctt ccc ggg tac ccc gac gcc gag gcc ccg      583
 Tyr Ile Val Glu Arg Pro Leu Pro Gly Tyr Pro Asp Ala Glu Ala Pro
              10                  15                  20

 gag cct tcc tcc gct ggg gct cag gca gcg gag gag ccg tcg ggg gcc      631
 Glu Pro Ser Ser Ala Gly Ala Gln Ala Ala Glu Glu Pro Ser Gly Ala
          25                  30                  35

 ggc tca gaa gag ctg atc aag tcg gac cag gtg aac ggc gtg ctg gtg      679
 Gly Ser Glu Glu Leu Ile Lys Ser Asp Gln Val Asn Gly Val Leu Val
      40                  45                  50

 ctg agc ctc ctg gac aaa atc atc ggg gcc gta gac cag atc cag ctg      727
 Leu Ser Leu Leu Asp Lys Ile Ile Gly Ala Val Asp Gln Ile Gln Leu
  55                  60                  65                  70

 act caa gca cag ctg gag gag cgg cag gcg gag atg gag ggc gca gtg      775
 Thr Gln Ala Gln Leu Glu Glu Arg Gln Ala Glu Met Glu Gly Ala Val
                  75                  80                  85

 cag agc atc cag ggc gag ctg agc aag ctg ggc aag gcg cac gcc acc      823
 Gln Ser Ile Gln Gly Glu Leu Ser Lys Leu Gly Lys Ala His Ala Thr
              90                  95                 100

 acg agc aat acg gtg agc aag ctg ctg gag aag gtg cgc aag gtc agc      871
 Thr Ser Asn Thr Val Ser Lys Leu Leu Glu Lys Val Arg Lys Val Ser
         105                 110                 115

 gtc aac gtg aag acc gtg cgc ggc agc ctg gag cgc cag gcg ggg cag      919
 Val Asn Val Lys Thr Val Arg Gly Ser Leu Glu Arg Gln Ala Gly Gln
     120                 125                 130

 atc aag aag ctg gag gtc aac gag gcc gag ctg ctg cgg cgc cgc aac      967
 Ile Lys Lys Leu Glu Val Asn Glu Ala Glu Leu Leu Arg Arg Arg Asn
 135                 140                 145                 150

 ttt aaa gtc atg atc tac cag gat gaa gtg aag ctg ccg gcc aaa ctg     1015
 Phe Lys Val Met Ile Tyr Gln Asp Glu Val Lys Leu Pro Ala Lys Leu
                 155                 160                 165

 agc atc agc aaa tcg ctg aaa gag tcg gag gcg ctg cca gag aag gag     1063
 Ser Ile Ser Lys Ser Leu Lys Glu Ser Glu Ala Leu Pro Glu Lys Glu
             170                 175                 180

 ggc gag gag ctg ggc gag ggc gag cgg ccc gag gag gac gca gcg gcg     1111
 Gly Glu Glu Leu Gly Glu Gly Glu Arg Pro Glu Glu Asp Ala Ala Ala
         185                 190                 195

 ctg gag ctt tcg tcg gac gag gcg gtg gag gtt gag gag gtt att gag     1159
 Leu Glu Leu Ser Ser Asp Glu Ala Val Glu Val Glu Glu Val Ile Glu
     200                 205                 210

 gag tcc cgc gca gag cgt atc aag cgc agc ggc ctg cgg cgc gtg gac     1207
 Glu Ser Arg Ala Glu Arg Ile Lys Arg Ser Gly Leu Arg Arg Val Asp
 215                 220                 225                 230

 gac ttc aag aag gcc ttc tcc aag gag aag atg gag aag acc aag gtg     1255
 Asp Phe Lys Lys Ala Phe Ser Lys Glu Lys Met Glu Lys Thr Lys Val
                 235                 240                 245

 cgt acc cgc gag aac ctg gag aag acg cgc ctc aag acc aag gaa aac     1303
 Arg Thr Arg Glu Asn Leu Glu Lys Thr Arg Leu Lys Thr Lys Glu Asn
             250                 255                 260

 ctg gag aag acg cgg cac acc ctg gag aag cgc atg aac aag ctg ggc     1351
 Leu Glu Lys Thr Arg His Thr Leu Glu Lys Arg Met Asn Lys Leu Gly
         265                 270                 275

 acg cgc ctg gtg ccc gcc gag cgg cgc gag aaa ctg aag acg tcg cgg     1399
 Thr Arg Leu Val Pro Ala Glu Arg Arg Glu Lys Leu Lys Thr Ser Arg
     280                 285                 290

 gac aag ttg cgc aaa tcc ttc acg ccc gac cac gtg gtg tac gcg cgc     1447
 Asp Lys Leu Arg Lys Ser Phe Thr Pro Asp His Val Val Tyr Ala Arg
 295                 300                 305                 310

 tcc aag acc gcg gtc tac aag gtg cca ccc ttc acc ttc cac gtc aag     1495
 Ser Lys Thr Ala Val Tyr Lys Val Pro Pro Phe Thr Phe His Val Lys
                 315                 320                 325

 aag atc cgc gag ggc cag gtg gaa gtg ctc aag gcc acc gag atg gtg     1543
 Lys Ile Arg Glu Gly Gln Val Glu Val Leu Lys Ala Thr Glu Met Val
             330                 335                 340

 gag gtg ggc gcc gac gac gac gag ggc ggc gcg gag cgc ggg gag gcc     1591
 Glu Val Gly Ala Asp Asp Asp Glu Gly Gly Ala Glu Arg Gly Glu Ala
         345                 350                 355

 ggc gac ctg cgg cgc ggg agc agc ccc gac gtg cac gcg ctg ctg gag     1639
 Gly Asp Leu Arg Arg Gly Ser Ser Pro Asp Val His Ala Leu Leu Glu
     360                 365                 370

 atc acc gag gag tcg gac gcc gtg ctg gtg gac aag agc gac agc gac     1687
 Ile Thr Glu Glu Ser Asp Ala Val Leu Val Asp Lys Ser Asp Ser Asp
 375                 380                 385                 390

 tga gccg cccccgctgc cacccacccc attcctcgct ccttccgaac ttcctctttc     1744
 


 gcattctctc tcggctcgag ctggctgaga tttttctaaa ttgaaaacac gcccccctcc   1804

 ccacacctcc aggaactcca ctcccagtct tagagctgtt aggacccgat ggggaggcag   1864

 cccccgcagt ggacagcccc cgcttggaca cagtccgagt ggaatgggaa gggaatggtc   1924

 aatccctgtc ctggttgtcc aagtcgggat ctcagaggaa attgcagtga ttccacggtt   1984

 aggcccccct gggggggctg ccttcccctc agcctctccc cacaccaccc acccagctgc   2044

 tgtcattccg ctcactgagc tcttcttcat tctcaccctg atccctgggg gactcaaagc   2104

 caaaactgcc caaagaggaa agattgaatc ctaaagggga tccttgcccc catgggaggc   2164

 cccctactag aaggacgtga aagcagcttt tgggggaaac tgaggcagtg gggaagacag   2224

 agcagaatga gccctcaccc tggctggggg tccagcacag gctgtatctg cagagggtcc   2284

 cagaggaacg ctggagccaa gagaagccct gggaaggagg ggtggggaac gacatgcatg   2344

 tgagggatgg cacactgatg tgtttatgca cctgtacaca ggagcgcatg gccatggctt   2404

 tggaaaggag aatgg                                                    2419




      <210> 370
      <211> 2230
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (309)..(1019)

      <400> 370
 caggccttcg ccacgagtca gagcggggca catgtaggca gcgtggtgcc cggacccatc     60

 ctccccgagc agctggctga tggagccacc caggtggtcg tcgtgggggg ctccatggaa    120

 ggccacggca tggatgagtc cctcagtcca ggtggcgctg tgatacaaca ggtgaccaag    180

 caggagattt taaacctctc ggaggctgga gtcgctcccc ccgaggcatc ctcagccctg    240

 gatgcattgc tctgtgcggt cactgaatta ggggaggtag aggcagggct gggctcgatg    300

 agcaaggc atg ccc gtc gcc ata gac gtg ctg atc cat ctg ccc gga cag     350
          Met Pro Val Ala Ile Asp Val Leu Ile His Leu Pro Gly Gln
            1               5                  10

 gag gtc tcc cat gtg gct gcc gac ccc gag gcc ccc gag atc cag atg      398
 Glu Val Ser His Val Ala Ala Asp Pro Glu Ala Pro Glu Ile Gln Met
  15                  20                  25                  30

 ttc cca cag gcc cag gag agc ccg gcc gcc gtg gag gtg ctc acc cag      446
 Phe Pro Gln Ala Gln Glu Ser Pro Ala Ala Val Glu Val Leu Thr Gln
                  35                  40                  45

 gtg gtc cat ccc tca gca gcc atg gcc tct cag gag cgg gca cag gtg      494
 Val Val His Pro Ser Ala Ala Met Ala Ser Gln Glu Arg Ala Gln Val
              50                  55                  60

 gcc ttc aag aag atg gtc cag ggc gtc ctc cag ttt gct gtg tgt gac      542
 Ala Phe Lys Lys Met Val Gln Gly Val Leu Gln Phe Ala Val Cys Asp
          65                  70                  75

 acg gcc gcg gcc ggc cag ttg gtc aag gac ggt gtc acc cag gtg gtg      590
 Thr Ala Ala Ala Gly Gln Leu Val Lys Asp Gly Val Thr Gln Val Val
      80                  85                  90

 gtg agc gaa gag ggt gcc gtc cac atg gtc gcc ggg gag ggt gcc cag      638
 Val Ser Glu Glu Gly Ala Val His Met Val Ala Gly Glu Gly Ala Gln
  95                 100                 105                 110

 atc atc atg cag gag gcg cag ggc gag cac atg gat ctg gtg gag tcc      686
 Ile Ile Met Gln Glu Ala Gln Gly Glu His Met Asp Leu Val Glu Ser
                 115                 120                 125

 gac ggg gag atc tcg cag atc atc gtg aca gag gag ctg gtc cag gcc      734
 Asp Gly Glu Ile Ser Gln Ile Ile Val Thr Glu Glu Leu Val Gln Ala
             130                 135                 140

 atg gtg cag gag tcc agt ggc ggc ttc tcc gag ggc acc acg cac tac      782
 Met Val Gln Glu Ser Ser Gly Gly Phe Ser Glu Gly Thr Thr His Tyr
         145                 150                 155

 atc ctg aca gag ctg ccc cca ggg gtg cag gac gag ccg ggc ctg tac      830
 Ile Leu Thr Glu Leu Pro Pro Gly Val Gln Asp Glu Pro Gly Leu Tyr
     160                 165                 170

 tcc cac acc gtg ctg gag act gcg gac tcg cag gaa ctc ctg cag gcc      878
 Ser His Thr Val Leu Glu Thr Ala Asp Ser Gln Glu Leu Leu Gln Ala
 175                 180                 185                 190

 ggg gcc acg cta ggc aca gag gcc ggg gcc cca agc agg gca gag cag      926
 Gly Ala Thr Leu Gly Thr Glu Ala Gly Ala Pro Ser Arg Ala Glu Gln
                 195                 200                 205

 ctg gcc agc gtg gtc atc tac acc cag gag ggc tcc tcg gcc gcg gcg      974
 Leu Ala Ser Val Val Ile Tyr Thr Gln Glu Gly Ser Ser Ala Ala Ala
             210                 215                 220

 gca att cag agc caa aga gaa agc agc gaa ctc cag gaa gca tga gac     1022
 Ala Ile Gln Ser Gln Arg Glu Ser Ser Glu Leu Gln Glu Ala 
         225                 230                 235

 gcgcggcacc tttactcagc acagggcagg tgtgggaagg tccagcttcg gtgggggacc   1082

 gtgttccctg agcttcatct gaaaccttca aaaccatgag gacaaggctc ccgtgagctc   1142

 tgagcatgcc ctcccagcga gagtcacact ggccaccagc caggcgccca cagagggtac   1202

 cgtgggctgg gcctcgggga gcaggctgcc aagtgcaggg gagggccggg cgcaggccgc   1262

 acagggagct ccggtccact gggggccctt cgatcagtgg cctcccgctt cgtcctggcc   1322

 gctgtgctga agagaagcca agtgttgttg gtgtttttct ctcccaagtg ttttcccatt   1382

 tcagttatca gaaggtcatg gccgtgggga aagtggtgaa gatacccctc gtggcttggg   1442

 gtgcacctgc ttgtgcagtc agcatgtagc tgcctttcca tttcattctc tactgggcta   1502

 aaaattgcag ctacaagtgt taccatcttg aagcagtcca cttccattca attttttttt   1562

 tttaatttta gaataacagt gtccccatac caaaggaagc ctgctagctc atttcatgta   1622

 taaatttccc atcttcaaac agtttaggtg tatttgttgc tctggtcaca ttctgcataa   1682

 aagaaatcct cttaagccta tggttaagaa aagccttgaa gtttatattc agttaaaata   1742

 tatgtcggtg gagatagcca gtgcttctaa ttttgactta gtttcataca gtaaagccta   1802

 aatgtgaaac gcacacgctg gaagatattg ttcctatcaa tattttgctt tttataacaa   1862

 gggtttgttc atattgatgc catttttgca ggatttcttc gtgatttctg tccatatgaa   1922

 aatgctgaca ttaaacatta acacatggag accgtgccct gtggccctgc cgtggctgcc   1982

 agcatggtct gtgtttcctt gtggattcac ctgtggccct gctgtggcca ccagcatggt   2042

 ctgtgtcctc gtggattcac tgcagctgtc ggatgcgagt ttctgtcata atcatttgtt   2102

 tcctgataca attgttctta ttcttttcca aaactgtaaa ataatctcct ccctcaaatg   2162

 caaaggttgt ttttgttctg tttctgtttt ctttgaaata aaattataac gttaaaagaa   2222

 aaaaaaaa                                                            2230




      <210> 371
      <211> 814
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(561)

      <400> 371
 gtgttttctt agcacgcagt gaggaatctt tgtacttaag gccagggcaa caaagtcaag     60

 aggtcaaggt gtagggcc  atg agg cct gga cct atg ctg cag gca agg gtt     111
                      Met Arg Pro Gly Pro Met Leu Gln Ala Arg Val
                        1               5                  10

 tcc atc ccc gct gcc cta ggc act ctc ttc cca agg cca ggt tgg gca      159
 Ser Ile Pro Ala Ala Leu Gly Thr Leu Phe Pro Arg Pro Gly Trp Ala
              15                  20                  25

 cct ggg gag gtc agt tca gaa ata tct agc aga gac ctc tta aac ccc      207
 Pro Gly Glu Val Ser Ser Glu Ile Ser Ser Arg Asp Leu Leu Asn Pro
          30                  35                  40

 cat ccc agc acc cca tcc tgt tgt tcc cag agc tgg tct ccc atg agt      255
 His Pro Ser Thr Pro Ser Cys Cys Ser Gln Ser Trp Ser Pro Met Ser
      45                  50                  55

 gtg cta gag cca gat agc cgt ggc ccc cca ccc atc tca ctc aca cac      303
 Val Leu Glu Pro Asp Ser Arg Gly Pro Pro Pro Ile Ser Leu Thr His
  60                  65                  70                  75

 aca ggc atc cat aca ccc cag aag act tcc caa atg agg cca gac tca      351
 Thr Gly Ile His Thr Pro Gln Lys Thr Ser Gln Met Arg Pro Asp Ser
                  80                  85                  90

 ggg tca cgg gga atg tgc ttc tgc ccc tgt aag ggc ttt ggg gaa ggg      399
 Gly Ser Arg Gly Met Cys Phe Cys Pro Cys Lys Gly Phe Gly Glu Gly
              95                 100                 105

 ggc aac ata gta gag gct gga aag agc ccc caa acc tgt gcc cat gcc      447
 Gly Asn Ile Val Glu Ala Gly Lys Ser Pro Gln Thr Cys Ala His Ala
         110                 115                 120

 cct cca gcc ctg cgt ttc cat tct gcc ttc tca gag tgc cct tgc tgc      495
 Pro Pro Ala Leu Arg Phe His Ser Ala Phe Ser Glu Cys Pro Cys Cys
     125                 130                 135

 acc cag acc acc ggc cag gag aga cct tct ctc cca ctc cag ccc ctc      543
 Thr Gln Thr Thr Gly Gln Glu Arg Pro Ser Leu Pro Leu Gln Pro Leu
 140                 145                 150                 155

 tca ctg ccc ttc aac tag agcttt caccttttta catttccctt ctgaaggaca      597
 Ser Leu Pro Phe Asn 
                 160

 caaatctgct tttctgccca tacactggcc caagggctca cctaacttgg gagggaaggg    657

 gctgttggta caaggatgat tttctgttag actgccattt tgcacggtct cccccttccc    717

 atctgatgtg tcctgcccct cagctctttg ccttatctgt gtcactgtca ctttagcaaa    777

 aatacagcgg ccatttgtat cagcaaaaaa aaaaaaa                             814




      <210> 372
      <211> 429
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (191)..(385)

      <400> 372
 aattatctca ctaaaaaaaa tgctagtact taaagtgatg taacattttg caaaattttc     60

 attttcgcat tcctgctgat ttcaaacctt cccatggttt ataagcataa cctgtaatgt    120

 aatgcaagtc ccctaactcc ctggttgcta acattaactt ccttaagtaa taatcaatga    180

 aagaaattct   atg cat ggc tgt gaa ata ata tcc ttg aaa gag gaa tca     229
              Met His Gly Cys Glu Ile Ile Ser Leu Lys Glu Glu Ser
                1               5                  10

 cca tta gga aag gtg agt cag ggt cct ttg ttt aat gtg act agt ggc      277
 Pro Leu Gly Lys Val Ser Gln Gly Pro Leu Phe Asn Val Thr Ser Gly
      15                  20                  25

 tca tca tca cca gtg acc tgg ttg ggc cta ctc tcc ttc cag aac ctg      325
 Ser Ser Ser Pro Val Thr Trp Leu Gly Leu Leu Ser Phe Gln Asn Leu
  30                  35                  40                  45

 cat tgc ttc cca gac ctc ccc act gag atg cct cta aga gcc aaa gga      373
 His Cys Phe Pro Asp Leu Pro Thr Glu Met Pro Leu Arg Ala Lys Gly
                  50                  55                  60

 gtc aac act tga gcc tagggtgggc tacaacaaaa gattctaatt taccttgctt      428
 Val Asn Thr 


 c                                                                    429




      <210> 373
      <211> 993
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (118)..(435)

      <400> 373
 tttcgtgtct gggaggtagg tttgtgagcg tgagagatcg atctgtaccg cggggatccg     60

 aagtatgctt atccaggtgg gctgcctcaa gcctcgatcc cacccccgcg ctggtag       117                                                                 
 atg gtg tca agg tcc ttg cgt ggg aga agg act tgg gtg aga tgc atg      165
 Met Val Ser Arg Ser Leu Arg Gly Arg Arg Thr Trp Val Arg Cys Met
   1               5                  10                  15

 cgg aga ttg ccc cca att ccg gcc tgg agc caa ggg aaa ggg atg cct      213
 Arg Arg Leu Pro Pro Ile Pro Ala Trp Ser Gln Gly Lys Gly Met Pro
              20                  25                  30

 gga ttt gtg tct cta ttg gtg gtc cac gct gcg gat gcc tgg gta gcc      261
 Gly Phe Val Ser Leu Leu Val Val His Ala Ala Asp Ala Trp Val Ala
          35                  40                  45

 cag agg tta tct acg cca tac ttc tca ctg ttt ttg agc ata cct aga      309
 Gln Arg Leu Ser Thr Pro Tyr Phe Ser Leu Phe Leu Ser Ile Pro Arg
      50                  55                  60

 tgt tcc ttt cct agg cgg agt ata gat cgc acg tgt tct agc ctc tta      357
 Cys Ser Phe Pro Arg Arg Ser Ile Asp Arg Thr Cys Ser Ser Leu Leu
  65                  70                  75                  80

 gac tca gag ggt tcg agc tct ata agc ccc tcc act ccc ttc att tta      405
 Asp Ser Glu Gly Ser Ser Ser Ile Ser Pro Ser Thr Pro Phe Ile Leu
                  85                  90                  95

 caa atg aga ctc aaa cct aga gcg cgg taa t gaccttacta agaccaaatg      456
 Gln Met Arg Leu Lys Pro Arg Ala Arg 
             100                 105

 gctggtgaat tgggcttcac tagaatccag gcttgctggc taacaccaat gctccctcca    516

 tcatttcatg ttatgttttc atttcccctc tgtctgagag attgctctga tgtctttcct    576

 tccataagtc ctacggagat cgagcttacc tcatttttct cccaggccta gcgagctcaa    636

 ttaccaggat cactttcttc cccagggtgt actacagacc tccacatgtt ggacagtagg    696

 attcagcaga gaatgagtcc cacatcctct tttcatccat aagcattctt cccaatatct    756

 tccggcttca tggcctatgt actttacgct cagctggttg gggactctcc caaaggttga    816

 agaaggcagc cgaattgtcg aaagggctca cggagggttg gatagaaacc ctgaggggat    876

 gtccgcacct cagagggacc cggggggtgg gacacttccc aaaaagtccg gggacggaaa    936

 agtgggcgcc caaaggtgga agggggccac cccgctactt tccctcggga ggtttgt       993




      <210> 374
      <211> 434
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (214)..(390)

      <400> 374
 gtgccattcg aaagacttct ttaaaaaagc gtttttgtta aggagtctgg gaatcatgga     60

 atcatagtga ccagtaactg ttatggactg gattgtatcc ccctccaatt cagttatggt    120

 gctgcttcag aaagaaaaga gatagtttcc cttgcaaagt tatcaaagtg ctccccagaa    180

 gacattaggt atttgctttc tagtctacat aca atg aaa agg aaa aaa cgt cag     234
                                      Met Lys Arg Lys Lys Arg Gln
                                        1               5

 ttc ctg aag ctc tct caa aac atc aac aga tgg aaa gac gtg ccc atg      282
 Phe Leu Lys Leu Ser Gln Asn Ile Asn Arg Trp Lys Asp Val Pro Met
          10                  15                  20

 tcc tcc cct ccc tcc act ctg ggg gct tgg aaa tgc tgc agc agg gag      330
 Ser Ser Pro Pro Ser Thr Leu Gly Ala Trp Lys Cys Cys Ser Arg Glu
      25                  30                  35

 cag gcc cca ggc tgg acc tgc cct gtc ctc acg acg agt gtg tgc aaa      378
 Gln Ala Pro Gly Trp Thr Cys Pro Val Leu Thr Thr Ser Val Cys Lys
  40                  45                  50                  55

 agt gaa caa taa atc atttcaaaga tgcaaggaag aaaaaccaaa acatcaacag      433
 Ser Glu Gln 


 a                                                                    434




      <210> 375
      <211> 1882
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(795)

      <400> 375
 aag  atg gcg gcg ccc agt ggc act gtg agc gat tcg gaa agt agt aac      48
      Met Ala Ala Pro Ser Gly Thr Val Ser Asp Ser Glu Ser Ser Asn
        1               5                  10                  15

 agc agt agc gat gcg gag gag ctg gag cgg tgc cgc gag gcg gca atg       96
 Ser Ser Ser Asp Ala Glu Glu Leu Glu Arg Cys Arg Glu Ala Ala Met
                  20                  25                  30

 ccg gct tgg ggc ttg gag caa cgc ccg cac gtg gca ggg aag cca aga      144
 Pro Ala Trp Gly Leu Glu Gln Arg Pro His Val Ala Gly Lys Pro Arg
              35                  40                  45

 gcc ggt gct gca aat agc cag ttg tca acc tcc caa ccg agc ctc agg      192
 Ala Gly Ala Ala Asn Ser Gln Leu Ser Thr Ser Gln Pro Ser Leu Arg
          50                  55                  60

 cat aag gtg aat gag cat gaa caa gat ggc aac gag ctt cag acc acc      240
 His Lys Val Asn Glu His Glu Gln Asp Gly Asn Glu Leu Gln Thr Thr
      65                  70                  75

 cct gaa ttc cga gcc cac gta gcc aag aag ctg gga gcc ctg ctg gac      288
 Pro Glu Phe Arg Ala His Val Ala Lys Lys Leu Gly Ala Leu Leu Asp
  80                  85                  90                  95

 agc ttc att acc atc tca gaa gca gca aag gag cca gca aaa gct aag      336
 Ser Phe Ile Thr Ile Ser Glu Ala Ala Lys Glu Pro Ala Lys Ala Lys
                 100                 105                 110

 gta cag aaa gtc gct ttg gag gat gat ggt ttc cgc ctt ttc ttc aca      384
 Val Gln Lys Val Ala Leu Glu Asp Asp Gly Phe Arg Leu Phe Phe Thr
             115                 120                 125

 tct gtc cct gga ggc cgt gag aag gaa gag tct ccc caa ccc cgc cga      432
 Ser Val Pro Gly Gly Arg Glu Lys Glu Glu Ser Pro Gln Pro Arg Arg
         130                 135                 140

 aag cga cag ccc tcc agc tcc agc agt gag gac agt gac gag gag tgg      480
 Lys Arg Gln Pro Ser Ser Ser Ser Ser Glu Asp Ser Asp Glu Glu Trp
     145                 150                 155

 cgg cgg tgc cgg gag gca gct gtg tcg gcg tcc gac atc cta cag gag      528
 Arg Arg Cys Arg Glu Ala Ala Val Ser Ala Ser Asp Ile Leu Gln Glu
 160                 165                 170                 175

 tca gcc atc cac agc cct gga aca gtg gag aag gag gca aag aag aaa      576
 Ser Ala Ile His Ser Pro Gly Thr Val Glu Lys Glu Ala Lys Lys Lys
                 180                 185                 190

 agg aag ttg aaa aag aaa gcc aag aag gtg gcc agt gtc gac tcg gct      624
 Arg Lys Leu Lys Lys Lys Ala Lys Lys Val Ala Ser Val Asp Ser Ala
             195                 200                 205

 gtc gct gcc acc acc ccc acc agc atg gcc aca gtc cag aag cag aag      672
 Val Ala Ala Thr Thr Pro Thr Ser Met Ala Thr Val Gln Lys Gln Lys
         210                 215                 220

 tca ggt gag ctc aac ggg gac cag gtg tcg ctt ggg acc aaa aag aag      720
 Ser Gly Glu Leu Asn Gly Asp Gln Val Ser Leu Gly Thr Lys Lys Lys
     225                 230                 235

 aaa aag gca aag aag gcc agc gag acc tct cca ttc cca cca gca aag      768
 Lys Lys Ala Lys Lys Ala Ser Glu Thr Ser Pro Phe Pro Pro Ala Lys
 240                 245                 250                 255

 agt gct aca gct ata cct gca aac tga accca gccatgggca cagggctcag      820
 Ser Ala Thr Ala Ile Pro Ala Asn 
                 260

 ccagctccaa ggacaaggtg tcccccccac cctggggaca aggcatttcc aagccccacc    880

 tccctctcca agttcaagga ctgggctggc aaacccagac tgcccatgag accctgatgg    940

 tgatgaaggc ttgctcgaga gttgggccaa aaaagtggct gtagggtgag aagaccaatc   1000

 aaggcctgcc cctctgtgct cccacggagg gctggcgggg gcgctgtggt tccagaacat   1060

 ttcatgacct caggaaaaaa ggaaccttcc agttatttga gactagtggc caagtggtga   1120

 aacctccatc tccctagaac tgtctgaggt gggcagggga agggagacct tccccaccac   1180

 ctccttagcc tggtgtgaga aacagttttt agaaaatgag agaagggatc cccaagaggc   1240

 caaggcccag agaaactttt gttcttctct ccttagccca catagacttc acagaatcgt   1300

 ctgagaaagg agagcttttt cacccctggc tttctagaat tttctttgtc tgcatttgtg   1360

 aatataccac acatgatggt gtctctgagc cgaccagatt atggaaactc aattgtcaga   1420

 ggacccaaaa caaaacttag agtgatttgg atattgcctc tctgtcaatg ctgaacctta   1480

 agacatttta agtaaacatc ctcctcctct ctacaccccc aggatttgtg cgttcacccc   1540

 acccaagact tcaggaagtg tcatacgcac cgcggcgcga caaaggatac ccacggggac   1600

 caaacggcgc cttccgccac cacaagccca gaagccagac ggcccgagat gcagaggccc   1660

 ccaaggccct gcgaagaccc acgcgcatac cccacgcggc ccaagggagg gagcgaacca   1720

 cccgaaggcg cacgacagtc tggcaacaac aggactgtgc accaaaaggg agaagaagcc   1780

 cccaccacgc cccacagcac gccccacccg acacacaaac agcactaaac cacgacgagg   1840

 cccaacaaca cgccgaccca gacgaccatc accaccaccc ac                      1882




      <210> 376
      <211> 1187
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (255)..(956)

      <400> 376
 ttgacggggt cctaagatgg ctgctgggcg accacttcct gacagctcca gttaatggga     60

 ctgccagcag gctagacatc cttcgccgga atgtgcagcg cttagttctg tgcccgggag    120

 gggcttctct ctcttttggg attggagtgt ggcattgccg ccagaaagcc tgcagaattc    180

 cgggttgtgc agccaagcag gaacggtgta cctttctaga cccatcctct tgcaatcttg    240

 gaccctaaga aaag  atg tgg agt ggg ctg cta cct cct ggc cta aat gaa     290
                  Met Trp Ser Gly Leu Leu Pro Pro Gly Leu Asn Glu
                    1               5                  10

 agt gac gct gag tca aac tcg gaa gat gaa gct acg ttg gag aac tct      338
 Ser Asp Ala Glu Ser Asn Ser Glu Asp Glu Ala Thr Leu Glu Asn Ser
          15                  20                  25

 gga ctt aac tta cag gaa gat aaa gag gat gag agc atc aga aaa aca      386
 Gly Leu Asn Leu Gln Glu Asp Lys Glu Asp Glu Ser Ile Arg Lys Thr
      30                  35                  40

 gaa atc ata gat ttc tca aca gat gaa cca aaa act gaa aca gag tca      434
 Glu Ile Ile Asp Phe Ser Thr Asp Glu Pro Lys Thr Glu Thr Glu Ser
  45                  50                  55                  60

 aat gta aat gcc tat gaa gag tgt cct tct gga att ccc ata gat atg      482
 Asn Val Asn Ala Tyr Glu Glu Cys Pro Ser Gly Ile Pro Ile Asp Met
                  65                  70                  75

 tgg aat aaa ttt caa gaa ttg cat aaa aaa cat tct gaa cag aaa agc      530
 Trp Asn Lys Phe Gln Glu Leu His Lys Lys His Ser Glu Gln Lys Ser
              80                  85                  90

 aca acc tca aga ttc aga ggg aaa aga aga aaa cgc tcc aga aaa gat      578
 Thr Thr Ser Arg Phe Arg Gly Lys Arg Arg Lys Arg Ser Arg Lys Asp
          95                 100                 105

 aaa ttg aag aat gaa aaa gaa tta cat agt gaa ccg tcc tca aat gaa      626
 Lys Leu Lys Asn Glu Lys Glu Leu His Ser Glu Pro Ser Ser Asn Glu
     110                 115                 120

 acc cag tgg aaa gag ctt act cag tat ttt gga gtc aat gat aga ttt      674
 Thr Gln Trp Lys Glu Leu Thr Gln Tyr Phe Gly Val Asn Asp Arg Phe
 125                 130                 135                 140

 gac ccg cct gtt aaa agg aaa aaa gtt gag aag tca ggc ctt gaa aag      722
 Asp Pro Pro Val Lys Arg Lys Lys Val Glu Lys Ser Gly Leu Glu Lys
                 145                 150                 155

 agg ata gac cag gct gtg gag gag tgg aat att gag aag gct gag gaa      770
 Arg Ile Asp Gln Ala Val Glu Glu Trp Asn Ile Glu Lys Ala Glu Glu
             160                 165                 170

 ctc agc aac cag cta gct act cga gag ctt ggt gta aaa att gcc aaa      818
 Leu Ser Asn Gln Leu Ala Thr Arg Glu Leu Gly Val Lys Ile Ala Lys
         175                 180                 185

 gca gtt gcc tgc cac aac ttt gta aaa gcc aaa aag gag gtt gaa aat      866
 Ala Val Ala Cys His Asn Phe Val Lys Ala Lys Lys Glu Val Glu Asn
     190                 195                 200

 tca cag gct gcc cga aaa aag aag aaa ctt gca tgg ggg ttt gaa gca      914
 Ser Gln Ala Ala Arg Lys Lys Lys Lys Leu Ala Trp Gly Phe Glu Ala
 205                 210                 215                 220

 aag aag aga tgg gaa acc aaa agc aac atg gga tac atg taa cttgcca      963
 Lys Lys Arg Trp Glu Thr Lys Ser Asn Met Gly Tyr Met 
                 225                 230

 gagtgcttca agacatttgt agactcaaat gctcaattta ctgagaatgt tttcctgcct   1023

 atgttaatat gtcagaaaat tgatagcact aaaacaaaaa taagcataaa atttgggatt   1083

 ttgattatca gctcttttca gtctttcttt aaggactttg tcctattgaa gtgaataaaa   1143

 tgaagcattc tgttatttgt ataagaaatg taagaaaaaa aaaa                    1187




      <210> 377
      <211> 1071
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (338)..(934)

      <400> 377
 gaattccctg gtcgacgatt tcgtcctgaa gtcccgggtg aagcctctgg ttttaccaat     60

 tgcaggtcgg cttggctggg agagatggat ggcgggaaag gggcagcagt cttgaggagc    120

 agggagagga gtctttcctc ctgccagctt cccctgtcag ccccaacccc agcccacaca    180

 ttgtaccatc tcttctgctg tgactgggtt gcctgaattt gtgggagacc cgtgatccca    240

 tcccagagtg tgcgggggac ggaggtctag tgggacaatg tcatattata aatttggaat    300

 gctgaataga aaattataga ttttgatatt gaaggaa atg aag cga agc cta aat     355
                                          Met Lys Arg Ser Leu Asn
                                            1               5

 gaa aat tca gct cga agt aca gca ggc tgt ttg cct gtt ccg ttg ttc      403
 Glu Asn Ser Ala Arg Ser Thr Ala Gly Cys Leu Pro Val Pro Leu Phe
              10                  15                  20

 aat cag aaa aag agg aac aga cag cca tta act tct aat cca ctt aaa      451
 Asn Gln Lys Lys Arg Asn Arg Gln Pro Leu Thr Ser Asn Pro Leu Lys
          25                  30                  35

 gat gat tca ggt atc agt acc cct tct gac aat tat gat ttt cct cct      499
 Asp Asp Ser Gly Ile Ser Thr Pro Ser Asp Asn Tyr Asp Phe Pro Pro
      40                  45                  50

 cta cct aca gat tgg gcc tgg gaa gct gtg aat cca gag ttg gct cct      547
 Leu Pro Thr Asp Trp Ala Trp Glu Ala Val Asn Pro Glu Leu Ala Pro
  55                  60                  65                  70

 gta atg aaa aca gtg gac acc ggg caa ata cca cat tca gtt tct cgt      595
 Val Met Lys Thr Val Asp Thr Gly Gln Ile Pro His Ser Val Ser Arg
                  75                  80                  85

 cct ctg aga agt caa gat tct gtc ttt aac tct att caa tca aat act      643
 Pro Leu Arg Ser Gln Asp Ser Val Phe Asn Ser Ile Gln Ser Asn Thr
              90                  95                 100

 gga aga agc cag ggt ggt tgg agc tac aga gat ggt aac aaa aat acc      691
 Gly Arg Ser Gln Gly Gly Trp Ser Tyr Arg Asp Gly Asn Lys Asn Thr
         105                 110                 115

 agc ttg aaa act tgg aat aaa aat act ctg cct tgt gtc ttt tat gaa      739
 Ser Leu Lys Thr Trp Asn Lys Asn Thr Leu Pro Cys Val Phe Tyr Glu
     120                 125                 130

 atc gat cgt gaa ctt ccg aga ctg att aga ggc cga gtt cat aga tgt      787
 Ile Asp Arg Glu Leu Pro Arg Leu Ile Arg Gly Arg Val His Arg Cys
 135                 140                 145                 150

 gtt ggc aac tat gac cag aaa aag aac att ttc caa tgt gtt tct gtc      835
 Val Gly Asn Tyr Asp Gln Lys Lys Asn Ile Phe Gln Cys Val Ser Val
                 155                 160                 165

 aga ccg gcg tct gtt tct gaa caa aaa act ttc cag gca ttt gtc aaa      883
 Arg Pro Ala Ser Val Ser Glu Gln Lys Thr Phe Gln Ala Phe Val Lys
             170                 175                 180

 att gca gat gtt gag atg cag tat tat att aat gtg atg aat gaa act      931
 Ile Ala Asp Val Glu Met Gln Tyr Tyr Ile Asn Val Met Asn Glu Thr
         185                 190                 195

 taa gtag tgataaaagg aagtttagca taaattatag cagttttctg ttattgctta      988
 


 atttaccatc tccatagttt tatagctact attgtatttc acttgttgaa ttaaagtatt   1048

 tgaattcttt taaaaaaaaa aaa                                           1071




      <210> 378
      <211> 1404
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (675)..(881)

      <400> 378
 acagtgcggt ggaattcgta taaagcataa atacatacat aaaaacatgt tggctgccaa     60

 agttcccaat aagatgcttc ctgtgttttt tggcctttac ttagctgaat gatcaaagtt    120

 cagaaaatgg tctgcaaaag ttactccata tacaacccca aatctactac tttaaatgta    180

 acatcaactc agttgtatga atctggagcg taatatttat attagaatgt atatgtcatt    240

 taaaatattt tgaaagccct cataaatatt tatatttact aaactaatag catagacact    300

 atataaatcc gcagtgatgc ttatatatct taaattagta ataatgggtg ctatataatt    360

 attttcagtt actatccctg acactctgga atcttctcca tttctcccta tcactcaatt    420

 tcattttaat cattggacac ctttgcgttt tgctgctaac agtgtgtgta tgtcaccctc    480

 tttatatctg ggtttcccac ttgtctgaag ctctcctgat cttagaacct ggagctgcag    540

 attcctccat gtcagctccc atcacggccc caaagacaga gtcacttggt tgctgagtca    600

 cttggttgct ggaaaaatct ttggggaaag ctggtataag ctacacactg acctgtcccc    660

 agtgtttcca ggta  atg act tgg cac tcc aga gaa agt ttc atg ctg ttg     710
                  Met Thr Trp His Ser Arg Glu Ser Phe Met Leu Leu
                    1               5                  10

 cgt gtg gtg gct cca agc caa gca cct ggc atg cag gtc agc cct tcc      758
 Arg Val Val Ala Pro Ser Gln Ala Pro Gly Met Gln Val Ser Pro Ser
          15                  20                  25

 cag cgg gcg tgg cgt cgt cct ctt cac aga tgc cac gtt gca gcc cca      806
 Gln Arg Ala Trp Arg Arg Pro Leu His Arg Cys His Val Ala Ala Pro
      30                  35                  40

 agg cct cac cat ttt gcg ttt ttt aga aac cca ttt tct tgg tca ttt      854
 Arg Pro His His Phe Ala Phe Phe Arg Asn Pro Phe Ser Trp Ser Phe
  45                  50                  55                  60

 ata aag ctg ctt tat aga tat ctt tga tcctg gcatgccttg gtttcctctc      906
 Ile Lys Leu Leu Tyr Arg Tyr Leu 
                  65

 ccttccctct ttccaatcct ggtttcctaa cctcctcttg tagtaattct caactcaact    966

 caaagtccca agaatttgga atggtaggat gctgtgcggg gagctcgagg ctgaggcata   1026

 atcactgctt cggttctgct catcagggga cacgctccct tactcatggc agccatgttt   1086

 gattgtcaca gagccccccg aatactctgt ctatagtgac acactgtagg tgtcataaat   1146

 tttaagaaac ctgcttttaa gtactattta taggtttttc tgttatactt gcaacctagt   1206

 tttaaaatac atgaggattt tatgaaagct ttatacagac atttatagga aactcattct   1266

 ttgattttag gtgccattta aattgataac acttacttta taaaaagatg ctttttgtct   1326

 ggatagagcc ttatagttta aaatatcttc atatattgcc atttgatcaa ataaatttct   1386

 tacttagaaa aaaaaaaa                                                 1404




      <210> 379
      <211> 1891
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(1648)

      <400> 379
 ctggcctggc ccccggagct ccctggagtc ggtactgggg gcttcgtttt gtacgcaccg     60

 ttttctctct gtgctatggg agatgtcaag gaatcaaaga tgcaaataac accagaaact    120

 ccaggaagga tccctgtttt aaatcctttt gaaagtccta gtgattattc taatctcc      178                                                                 
 atg aac aaa ctc tcg cca gtc ctt ctg ttt tta aat caa caa aat tac      226
 Met Asn Lys Leu Ser Pro Val Leu Leu Phe Leu Asn Gln Gln Asn Tyr
   1               5                  10                  15

 caa ata gat aaa gat gtg gaa gac aaa aga caa aaa gcc att gaa gag      274
 Gln Ile Asp Lys Asp Val Glu Asp Lys Arg Gln Lys Ala Ile Glu Glu
              20                  25                  30

 ttt ttc act aaa gat gtc atc gta ccc tct cct tgg act gat cat gaa      322
 Phe Phe Thr Lys Asp Val Ile Val Pro Ser Pro Trp Thr Asp His Glu
          35                  40                  45

 ggg aaa cag ctt tca caa tgt cat tcc agt aaa tgc act aac ata aat      370
 Gly Lys Gln Leu Ser Gln Cys His Ser Ser Lys Cys Thr Asn Ile Asn
      50                  55                  60

 agt gac tct cca gtt gga aaa aag ctg acc att cat tct gag aaa agc      418
 Ser Asp Ser Pro Val Gly Lys Lys Leu Thr Ile His Ser Glu Lys Ser
  65                  70                  75                  80

 gat gct gct tgt cag aca ttg ctg tct ctt cct gtg gat ttt aat tta      466
 Asp Ala Ala Cys Gln Thr Leu Leu Ser Leu Pro Val Asp Phe Asn Leu
                  85                  90                  95

 gaa aat ata tta ggt gac tat ttt aga gct gat gaa ttt gca gat caa      514
 Glu Asn Ile Leu Gly Asp Tyr Phe Arg Ala Asp Glu Phe Ala Asp Gln
             100                 105                 110

 tct cct gga aac ctc agt tct tca tcc ctc aga aga aag ctg ttt tta      562
 Ser Pro Gly Asn Leu Ser Ser Ser Ser Leu Arg Arg Lys Leu Phe Leu
         115                 120                 125

 gat ggg aac gga agc atc tcc gac tcc tta cct tcg gct tct ccc gga      610
 Asp Gly Asn Gly Ser Ile Ser Asp Ser Leu Pro Ser Ala Ser Pro Gly
     130                 135                 140

 agt cct cac agt ggt gtt caa aca tca cta gag atg ttt tat tca ata      658
 Ser Pro His Ser Gly Val Gln Thr Ser Leu Glu Met Phe Tyr Ser Ile
 145                 150                 155                 160

 gat ttg tct cct gta aag tgt agg agc ccc ttg cag aca cca agt tcg      706
 Asp Leu Ser Pro Val Lys Cys Arg Ser Pro Leu Gln Thr Pro Ser Ser
                 165                 170                 175

 ggg cag ttt tct tct agc cct att cag gct agt gca aaa aaa tac agc      754
 Gly Gln Phe Ser Ser Ser Pro Ile Gln Ala Ser Ala Lys Lys Tyr Ser
             180                 185                 190

 ttg gga agc ata act agt cct tcg cct att tct tca ccc act ttc tca      802
 Leu Gly Ser Ile Thr Ser Pro Ser Pro Ile Ser Ser Pro Thr Phe Ser
         195                 200                 205

 cca att gaa ttt cag ata gga gag act cca ctc tca gaa caa agg aag      850
 Pro Ile Glu Phe Gln Ile Gly Glu Thr Pro Leu Ser Glu Gln Arg Lys
     210                 215                 220

 ttt act gtt cat tct cct gat gct tca tct gga aca aat tct aat ggg      898
 Phe Thr Val His Ser Pro Asp Ala Ser Ser Gly Thr Asn Ser Asn Gly
 225                 230                 235                 240

 ata act aat ccg tgt atc aga agt cct tat ata gat ggc tgc tcg cca      946
 Ile Thr Asn Pro Cys Ile Arg Ser Pro Tyr Ile Asp Gly Cys Ser Pro
                 245                 250                 255

 att aaa aat tgg tct cct atg aga ctt cag atg tat agt ggt ggt act      994
 Ile Lys Asn Trp Ser Pro Met Arg Leu Gln Met Tyr Ser Gly Gly Thr
             260                 265                 270

 cag tat cgg acc tca gtg att cag ata cct ttt act ctt gag act caa     1042
 Gln Tyr Arg Thr Ser Val Ile Gln Ile Pro Phe Thr Leu Glu Thr Gln
         275                 280                 285

 ggt gaa gat gag gaa gat aaa gag aat att cct tcc aca gat gtc tca     1090
 Gly Glu Asp Glu Glu Asp Lys Glu Asn Ile Pro Ser Thr Asp Val Ser
     290                 295                 300

 tca ccc gcc atg gat gct gct gga ata cac cta cgg cag ttt agt aat     1138
 Ser Pro Ala Met Asp Ala Ala Gly Ile His Leu Arg Gln Phe Ser Asn
 305                 310                 315                 320

 gag gct tct acc cat ggt aca cat ttg gtt gtg act gcc atg tct gtt     1186
 Glu Ala Ser Thr His Gly Thr His Leu Val Val Thr Ala Met Ser Val
                 325                 330                 335

 aca caa aat cag tcc agt gct tct gag aaa gaa tta gca ctg ttg cag     1234
 Thr Gln Asn Gln Ser Ser Ala Ser Glu Lys Glu Leu Ala Leu Leu Gln
             340                 345                 350

 gat gtt gaa agg gag aaa gac aat aac act gtg gat atg gtt gat cct     1282
 Asp Val Glu Arg Glu Lys Asp Asn Asn Thr Val Asp Met Val Asp Pro
         355                 360                 365

 ata gag ata gca gat gag acc act tgg att aag gag ccg gtt gat aat     1330
 Ile Glu Ile Ala Asp Glu Thr Thr Trp Ile Lys Glu Pro Val Asp Asn
     370                 375                 380

 ggc agt tta ccc atg act gat ttt gta agt ggc att gcc ttc agt att     1378
 Gly Ser Leu Pro Met Thr Asp Phe Val Ser Gly Ile Ala Phe Ser Ile
 385                 390                 395                 400

 gaa aac tct cat atg tgc atg tca cct ctt gct gaa agc agt gtc att     1426
 Glu Asn Ser His Met Cys Met Ser Pro Leu Ala Glu Ser Ser Val Ile
                 405                 410                 415

 cct tgt gaa agc agt aac att cag atg gat agt ggc tat aat acg cag     1474
 Pro Cys Glu Ser Ser Asn Ile Gln Met Asp Ser Gly Tyr Asn Thr Gln
             420                 425                 430

 aat tgt gga agc aat att atg gat aca gtt ggg gca gaa agt tac tgc     1522
 Asn Cys Gly Ser Asn Ile Met Asp Thr Val Gly Ala Glu Ser Tyr Cys
         435                 440                 445

 aaa gaa agt gat gca caa aca tgt gaa gtt gag agt aaa tct caa gca     1570
 Lys Glu Ser Asp Ala Gln Thr Cys Glu Val Glu Ser Lys Ser Gln Ala
     450                 455                 460

 ttt aat atg aag caa gac cac aca aca cag agg tgt tgg atg aaa aca     1618
 Phe Asn Met Lys Gln Asp His Thr Thr Gln Arg Cys Trp Met Lys Thr
 465                 470                 475                 480

 gca agc cct ttt caa tgc agc agt cca tag a atacctctgt cagaatcaaa     1669
 Ala Ser Pro Phe Gln Cys Ser Ser Pro 
                 485

 gactaagctt aagagttcct cgcatatatc gttgtgcaca ggatcaacat gatggtgact   1729

 gggaaaaaat tacttcaagt aacatgctta gctttccctc cttaatgtga aaaatcaagg   1789

 gcttactgac ataggaacaa cagaaatgct cctggaactt caagttgctg aattataagt   1849

 ttatttttta tcaataaata tttttatact taaaaaaaaa aa                      1891




      <210> 380
      <211> 510
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(393)

      <400> 380
 gaggggggca aatgcctcct cacgacctgt catgggcctt ctgtttaggg gttg  atg      57
                                                              Met
                                                                1

 gag aca cac cag gtc ttg ggg tct ttt tta atc cgc agg agg cct tgt      105
 Glu Thr His Gln Val Leu Gly Ser Phe Leu Ile Arg Arg Arg Pro Cys
               5                  10                  15

 ccc act tcc tct atg tcc ctt tcc ttg gtg tct gtg tct gtg ggg cca      153
 Pro Thr Ser Ser Met Ser Leu Ser Leu Val Ser Val Ser Val Gly Pro
          20                  25                  30

 tct aca ctg gcc tgt tcc ttc ctg aga cca aag gca aga cct tcc aag      201
 Ser Thr Leu Ala Cys Ser Phe Leu Arg Pro Lys Ala Arg Pro Ser Lys
      35                  40                  45

 aga tct cca agg aat tac aca gac tca act tcc cca ggc ggg ccc agg      249
 Arg Ser Pro Arg Asn Tyr Thr Asp Ser Thr Ser Pro Gly Gly Pro Arg
  50                  55                  60                  65

 gcc cca cgt gga gga gcc tgg agg tta tcc agt caa cag aac tct agt      297
 Ala Pro Arg Gly Gly Ala Trp Arg Leu Ser Ser Gln Gln Asn Ser Ser
                  70                  75                  80

 ccc aaa ggg gtg gcc aga gcc aaa gcc agc tac tgt cct gtc ctc tgc      345
 Pro Lys Gly Val Ala Arg Ala Lys Ala Ser Tyr Cys Pro Val Leu Cys
              85                  90                  95

 ttc ctg cca ggg ccc tgg tcc tca ctc cct cct gca ttc ctc att taa      393
 Phe Leu Pro Gly Pro Trp Ser Ser Leu Pro Pro Ala Phe Leu Ile 
         100                 105                 110

 ggagtgttta ttgagcaccc tttgtgtgca gacatggctc caggtgctta gcaatcaatg    453

 gtcagcgtgg tattccaggc taaaggtaat taactgacag aaaatcagta acaacat       510




      <210> 381
      <211> 653
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(652)

      <400> 381
 tttcgttctt tgacctccca taagagtcac gtgggctgac ccacagccgg ggcggaaagg     60

 ctgcgttagt ttcttccggg tcattgacag aagcgtcaat tcctgggagt agttcgttgg    120

 ttttctttcc cctcatcctt ttgcctgctc ccggcgaggg gtggctttga tttcggcg      178                                                                 
 atg agc tcc cag aaa ggc aac gtg gct cgt tcc aga cct cag aag cac      226
 Met Ser Ser Gln Lys Gly Asn Val Ala Arg Ser Arg Pro Gln Lys His
   1               5                  10                  15

 cag aat acg ttt agc ttc aaa aat gac aag ttc gat aaa agt gtg cag      274
 Gln Asn Thr Phe Ser Phe Lys Asn Asp Lys Phe Asp Lys Ser Val Gln
              20                  25                  30

 acc aag aaa att aat gca aaa ctt cat gat gga gta tgt cag cgc tgt      322
 Thr Lys Lys Ile Asn Ala Lys Leu His Asp Gly Val Cys Gln Arg Cys
          35                  40                  45

 aaa gaa gtt ctt gag tgg cgt gta aaa tac agc aaa tac aaa cca tta      370
 Lys Glu Val Leu Glu Trp Arg Val Lys Tyr Ser Lys Tyr Lys Pro Leu
      50                  55                  60

 tca aaa cct aaa aag tgt gtt aaa tgt tta caa aag aca gtg aag gat      418
 Ser Lys Pro Lys Lys Cys Val Lys Cys Leu Gln Lys Thr Val Lys Asp
  65                  70                  75                  80

 tct tat cac ata atg tgc agg cca tgt gcc tgt gaa ctt gaa gtt tgc      466
 Ser Tyr His Ile Met Cys Arg Pro Cys Ala Cys Glu Leu Glu Val Cys
                  85                  90                  95

 gca aaa tgt gga aag aaa gaa gac att gtt att ccg ttg aat aaa gaa      514
 Ala Lys Cys Gly Lys Lys Glu Asp Ile Val Ile Pro Leu Asn Lys Glu
             100                 105                 110

 aca gaa aaa ata gaa cat act gaa aat aat cta agt tcc aac cat aga      562
 Thr Glu Lys Ile Glu His Thr Glu Asn Asn Leu Ser Ser Asn His Arg
         115                 120                 125

 aga agc tgc aga aga aat gaa gaa agt gat gat gat tta gat ttt gat      610
 Arg Ser Cys Arg Arg Asn Glu Glu Ser Asp Asp Asp Leu Asp Phe Asp
     130                 135                 140

 att gat tta gaa gac aca gga gga gac cat caa atg aat taa t            653
 Ile Asp Leu Glu Asp Thr Gly Gly Asp His Gln Met Asn 
 145                 150                 155





      <210> 382
      <211> 547
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (126)..(449)

      <400> 382
 tcttgtctgc ccgccgctgg cctggccccg tctgtctctc tcagcagctg tctttctcgc     60

 gcccactggc cggtctctcc tcttccccgc agttgcctcc ttctctgcct gcctgggtgg    120

 ccgcc    atg ggc cgg aag cgg ctc atc act gat tcc tac ccg gtt gtg     167
          Met Gly Arg Lys Arg Leu Ile Thr Asp Ser Tyr Pro Val Val
            1               5                  10

 aag agg agg gag ggg ccc gct ggg cac agc aag ggg gag ctg gca ccc      215
 Lys Arg Arg Glu Gly Pro Ala Gly His Ser Lys Gly Glu Leu Ala Pro
  15                  20                  25                  30

 gag cta ggg gag gag ccc cag ccc cgc gac gag gag gaa gcg gag ctg      263
 Glu Leu Gly Glu Glu Pro Gln Pro Arg Asp Glu Glu Glu Ala Glu Leu
                  35                  40                  45

 gag ctg ctg agg cag ttt gac ctg gcc tgg cag tac ggg ccc tgc acc      311
 Glu Leu Leu Arg Gln Phe Asp Leu Ala Trp Gln Tyr Gly Pro Cys Thr
              50                  55                  60

 ggg atc aca cgg ctg cag cgc tgg tgt cgg gcc aag cag atg ggc ttg      359
 Gly Ile Thr Arg Leu Gln Arg Trp Cys Arg Ala Lys Gln Met Gly Leu
          65                  70                  75

 gag cct ccc cca gag gtg tgg cag gtg ctg aag acc cac ccc gga gac      407
 Glu Pro Pro Pro Glu Val Trp Gln Val Leu Lys Thr His Pro Gly Asp
      80                  85                  90

 ccc cgc ttc cag tgc agt ctc tgg cat ctc tat ccc cta tga ggcacca      456
 Pro Arg Phe Gln Cys Ser Leu Trp His Leu Tyr Pro Leu 
  95                 100                 105

 cgtaagacct cctgccctta gctctcttgc tcaccaccca agaacctcag gacagaagcg    516

 agagcccatt ggctcctgct cagctcagcc t                                   547




      <210> 383
      <211> 942
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (570)..(761)

      <400> 383
 tgatatccta ctccagtgcg gtggaattcg ccataatgtg tatggaaagt gtaacacatt     60

 cttactggtt aaagacgact accaggtatc taacttgttt aacattgagt ttgtgtgtgt    120

 gtgtgtatgt ttgtgtgttt tgtatattgt ttacattttg agaggtagca ttctgtttca    180

 aatgcttttt gtttttctga cagtattgtt gactgggtca taacattttg agctgtggtt    240

 tggtggattt tcaatttttt tttttaaagg tcattcgctg ggctatcttc aaaaccttga    300

 gtttggcccc caatttttgg cattcaaatg tttaaaagct atttatcttg gtttatacaa    360

 gtttcctttc tcttcttttt gtcatggtat tctatttggt ctgcagtttg aatgtagaga    420

 aagtggactg atcccccaag cgttgtctgc ccccactctt tcctccttgg gtcccgccat    480

 tcttttactg ggcagtcgag ggcattggag gggaagtgac tgccctcagc ctcactccct    540

 ggggccatga agaaaagcta aacagtctc  atg gca tct cag aat aat gtt ggg     593
                                  Met Ala Ser Gln Asn Asn Val Gly
                                    1               5

 tct ccc aag aag aaa ggt gta aga ata acg aca tgg ctg att agg cga      641
 Ser Pro Lys Lys Lys Gly Val Arg Ile Thr Thr Trp Leu Ile Arg Arg
      10                  15                  20

 ggc cag gat agg gct aag gcc agg att cct ggc tgg cat cca gtc acc      689
 Gly Gln Asp Arg Ala Lys Ala Arg Ile Pro Gly Trp His Pro Val Thr
  25                  30                  35                  40

 cct tct ccc atc ctt ccc cct ctt ctt cca caa gtc cgc agc cga gac      737
 Pro Ser Pro Ile Leu Pro Pro Leu Leu Pro Gln Val Arg Ser Arg Asp
                  45                  50                  55

 act gta gtc tcc cag cca cag tga tgagtgccct ggagactcca ctgacctcta     791
 Thr Val Val Ser Gln Pro Gln 
              60

 gatgaaggcc cctggccctg gttcctgtta attaacctct gggtctttga gtcccccagc    851

 acaaacttct ttcctgtacc ctgcggcttg gggtcacagg gcatgccggg aagccacagc    911

 tgaaggggcg cagactgaag cagtgctcca c                                   942




      <210> 384
      <211> 957
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (334)..(621)

      <400> 384
 cccttcagag attcttagaa gagttgctca ttcacaccca cgcccttgcc caaggctggc     60

 ccacttagag cgaaacttaa cttttgtctg gatgggaaga gaagtaagtc taccccgagg    120

 ttgccatgtt gaagagtgag aggtccaagt gattctgtgc attgaaacca agacacccca    180

 cccagaacac ttcttccctc cctcagccca aaccaaaggc tggggttctc atctccaagt    240

 ggctgttctc caactttccc aagccgcttg cattccccag actggactac tgtggcggtt    300

 aggttagatt tgaagacggg gcccaggctg ggt atg aac ggg tgc agc cct ctt     354
                                      Met Asn Gly Cys Ser Pro Leu
                                        1               5

 ctc ctc ttc ccc ccc aca tct ctc atg aga gag gta gtg gca ttt cct      402
 Leu Leu Phe Pro Pro Thr Ser Leu Met Arg Glu Val Val Ala Phe Pro
          10                  15                  20

 tct cag gga gct tca atg gga aag gtc tcg aaa gct tca gga gga gca      450
 Ser Gln Gly Ala Ser Met Gly Lys Val Ser Lys Ala Ser Gly Gly Ala
      25                  30                  35

 gaa tac caa cgc agg ggg atg gct gta acg atc tca ccg tct cct aac      498
 Glu Tyr Gln Arg Arg Gly Met Ala Val Thr Ile Ser Pro Ser Pro Asn
  40                  45                  50                  55

 ctc agt ccc ttt ttt gag agt gaa tgg tgg agg gtg gga agg gac cca      546
 Leu Ser Pro Phe Phe Glu Ser Glu Trp Trp Arg Val Gly Arg Asp Pro
                  60                  65                  70

 gat tgt aga tct ctt tgt ctg ggg gag ggg aag gat gtg gtt tgc aag      594
 Asp Cys Arg Ser Leu Cys Leu Gly Glu Gly Lys Asp Val Val Cys Lys
              75                  80                  85

 agc gga agc aga gtt gga cac gca tga gagca gagctcggtg ttcccaccct      646
 Ser Gly Ser Arg Val Gly His Ala 
          90                  95

 cagtgagagg tgtacattgg gtgaccatgt gacgtggatt tcccacccta caggaagaag    706

 tgtgagtgga ggtcgatata aggcaggctg gagttgggtc caaatgggga tgccaacgcc    766

 aagagacctg gctaacggtc attcagcagc tcaccacaca atacagtcaa cccgaaggtc    826

 agcagccagc acgccgtagg ggccgctggc cagcaaaaag gaacagcggg ggaccatgtc    886

 agatcatcac acggaacaaa aatacgcgat caaacactgt gtagtcatcg atactagctc    946

 agcaaacatt a                                                         957




      <210> 385
      <211> 1107
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(474)

      <400> 385
 aacactagtc cagggcggtg gaattcgctc aaccaggaac ccggaaatgc acaagcctct     60

 tgatgcataa aaacagctgg gctcccttgg agacagagcg cc   atg gga aac cgg     114
                                                  Met Gly Asn Arg
                                                    1

 gtc tgc tgc gga gga agc tgg agc tgc cca tca act ttc cag aag aaa      162
 Val Cys Cys Gly Gly Ser Trp Ser Cys Pro Ser Thr Phe Gln Lys Lys
   5                  10                  15                  20

 aag aaa aga gga agc caa aca aga cgg aca ctg aag ccg cag cca caa      210
 Lys Lys Arg Gly Ser Gln Thr Arg Arg Thr Leu Lys Pro Gln Pro Gln
                  25                  30                  35

 cag ctg cag cag aat ctc cca aag ggc cat gaa aca aca gga cat acg      258
 Gln Leu Gln Gln Asn Leu Pro Lys Gly His Glu Thr Thr Gly His Thr
              40                  45                  50

 tat gaa cgg gtg tta cag cag caa ggg tct caa gag agg agt cca ggc      306
 Tyr Glu Arg Val Leu Gln Gln Gln Gly Ser Gln Glu Arg Ser Pro Gly
          55                  60                  65

 ctc atg tcg gaa gac agc aac tta cat tat gct gac att caa gtg tgc      354
 Leu Met Ser Glu Asp Ser Asn Leu His Tyr Ala Asp Ile Gln Val Cys
      70                  75                  80

 agc cgt ccc cat gcc cgg gaa gtg aaa cac gtg cat tta gaa aac gct      402
 Ser Arg Pro His Ala Arg Glu Val Lys His Val His Leu Glu Asn Ala
  85                  90                  95                 100

 aca gag tat gcg acc ctt cgc ttc ccc cag gcc aca cct cgc tat gac      450
 Thr Glu Tyr Ala Thr Leu Arg Phe Pro Gln Ala Thr Pro Arg Tyr Asp
                 105                 110                 115

 agc aag aac ggg acc ctg gtg tga gcgcttggga ggaaggccca gtccatcgtt     504
 Ser Lys Asn Gly Thr Leu Val 
             120

 aaccactaca cctgtggggg agaacctact gctttgggga attgggtggc aacccaggga    564

 tgttgtccac gttttaagct taaagaactc caaagcccct ggaattgtgg gcgtcccatt    624

 ttctcccctg gcctcttact tgccactgtt aggttggagt taatagttgg tttagctatg    684

 ggtggatagc taaacttagc tatccacatg aggttaggtg gagtgtgcag ggaggtaggt    744

 cttcgacccc accattgttg ctcctgctct tgcaaagtgc agaaagagca ggtaaaaagt    804

 tagcccataa gcacgtgggc tgatcttgtt ggactttaat taatggtatc ctttttcaca    864

 caccttaaac tccaaagctg acaggggcag gtgtcccggg acaagccatt ctgaagcctt    924

 ctacatgccg acaccaggcg gcgggactga gccaatccac ccagcgcgga gtagcggtca    984

 caacctaacg acacaggggg caacaggccc gcacagtcgg aacacgtgca gcacaccgac   1044

 gtgctaagcc acccacgcgg cgcgaaaacc accggacgag acccctacag cgcgtataca   1104

 aac                                                                 1107




      <210> 386
      <211> 997
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (257)..(469)

      <400> 386
 aattcctttg catttccaaa ataaattaca caaatgtcac ttttcctttt ctattccata     60

 gtactagttt tagccagatc tttgccaaac attctaggac attcagaaaa gtcatccatg    120

 gaattttgga atgccattct ctctgtatct ttgcagatca tgaggaagga aagttgatga    180

 actagtacgg gatggctcag acttgtaaag tgtctaagtc acaacgctgc agagccagct    240

 tccgggtagc aatggc    atg gcc tca gct gtg cca agg cta caa ctg gag     289
                      Met Ala Ser Ala Val Pro Arg Leu Gln Leu Glu
                        1               5                  10

 ctt cct tac tcg cat ctg agg caa aca cag caa ggc tgg ccc agg ccg      337
 Leu Pro Tyr Ser His Leu Arg Gln Thr Gln Gln Gly Trp Pro Arg Pro
              15                  20                  25

 ccc aca gtc aac aga tgt tca cgg gag atg gat cag ccc ctc ttt tgc      385
 Pro Thr Val Asn Arg Cys Ser Arg Glu Met Asp Gln Pro Leu Phe Cys
          30                  35                  40

 ttg ttc tat caa gga aag aga tct aac cat ggg caa ggg tgg aac aca      433
 Leu Phe Tyr Gln Gly Lys Arg Ser Asn His Gly Gln Gly Trp Asn Thr
      45                  50                  55

 ccc ggt tca ggt cag gga atg agt tgc tct aag tga acag tgaattctta      483
 Pro Gly Ser Gly Gln Gly Met Ser Cys Ser Lys 
  60                  65                  70

 cttctcagcc tgtatcaatt gtacccaggg ttcatgatta ctgtgaccca ctaagggacg    543

 atctttgagg aaacagacct ggagggaggt aatttaagga gggaaagtga gtgggtttta    603

 cagactgctt tgtggcgaca ttcaggaaca gaccattcaa tggatgactt ttcagtacat    663

 aaaagcaagc agtaatggcc aggagagagc aaagatgccc taagaatgac atcagactga    723

 ccaaatgtgc cttttcaaat aagttatgag aacgaatgaa ttggaattag agcaaggtat    783

 tggacagaac catgctagtc tttgagagaa cgtgtggatt gggtggatgt ttggaccgaa    843

 tgaatggtaa ctttttaatg tgaaacagag aactgatata tgggctgtca tgtcacccta    903

 gggtactgtc gctctgtcat gtgtagcaat ctttccaaat ttttgttggt gggctgaaca    963

 aagataaaac taataaagta tgtgtggata ccaa                                997




      <210> 387
      <211> 915
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (160)..(651)

      <400> 387
 gattcagccc ccctaaccca ccttgaacat tgaccaccac acactccctg gcacgctctt     60

 ctcaccctca acttctgcca cctctccctg ggcaatactg ccagcctttc cctaatctca    120

 gagctgcagc cctgccctgt cactcacctc aaacctgcc   atg tcc ctg ggg cta     174
                                              Met Ser Leu Gly Leu
                                                1               5

 ctg aaa ttc cag gca gtg ggt gaa gag gac gag gag gat gag gag ggg      222
 Leu Lys Phe Gln Ala Val Gly Glu Glu Asp Glu Glu Asp Glu Glu Gly
                  10                  15                  20

 gag agc ctg gac tct gtg aag gca ctg aca gcc aag ctg cag ctg cag      270
 Glu Ser Leu Asp Ser Val Lys Ala Leu Thr Ala Lys Leu Gln Leu Gln
              25                  30                  35

 act cgg cgg ccc tca tat ctg gag tgg aca gcc cag gtc cag agc cag      318
 Thr Arg Arg Pro Ser Tyr Leu Glu Trp Thr Ala Gln Val Gln Ser Gln
          40                  45                  50

 gcc tgg cgc agg gcc caa gcc aaa cct gga cca ggg gga cct ggg gac      366
 Ala Trp Arg Arg Ala Gln Ala Lys Pro Gly Pro Gly Gly Pro Gly Asp
      55                  60                  65

 atc tgt ggt ttc gac tca atg gac tcc gcc ctt gag tgg ctc cga cgg      414
 Ile Cys Gly Phe Asp Ser Met Asp Ser Ala Leu Glu Trp Leu Arg Arg
  70                  75                  80                  85

 gag ctg cgg gag atg cag gcg cag gac agg cag ctg gca ggg cag ctg      462
 Glu Leu Arg Glu Met Gln Ala Gln Asp Arg Gln Leu Ala Gly Gln Leu
                  90                  95                 100

 ctg cgg ctg cgg gcc cag ctg cac cga ctg aag atg gac caa gcc tgt      510
 Leu Arg Leu Arg Ala Gln Leu His Arg Leu Lys Met Asp Gln Ala Cys
             105                 110                 115

 cac ctg cac cag gag ctg ctg gat gag gcc gag ctg gag ctg gag ctg      558
 His Leu His Gln Glu Leu Leu Asp Glu Ala Glu Leu Glu Leu Glu Leu
         120                 125                 130

 gag ccc ggg gcc ggc cta gcc ctg gcc ccg ctg ctg cgg cac ctg ggc      606
 Glu Pro Gly Ala Gly Leu Ala Leu Ala Pro Leu Leu Arg His Leu Gly
     135                 140                 145

 ctc acg cgc atg aac atc agc gcc cgg cgc ttc acc ctc tgc tga gga      654
 Leu Thr Arg Met Asn Ile Ser Ala Arg Arg Phe Thr Leu Cys 
 150                 155                 160

 acacctgtgc cccccgactc cccgccccct ctcccaatgc cgcttcccct gcctgcctgg    714

 gaagaggaaa gggaggggtg ccccagaggc accagctcct ggcgggggag gaggaacatt    774

 caggtttctg agagctgaat tccaagagtg caaaacccca gcatcctgtt tcctctgctg    834

 acccagctgg gagggggagg aggaggagct cacaccctca aactcctcaa taaacgcttt    894

 ctctggttcc caaaaaaaaa a                                              915




      <210> 388
      <211> 703
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (91)..(519)

      <400> 388
 cgccggctgt gacaagcgct gcggcatttg tccccgcgac agcaccgctg ccgccgtctc     60

 taaggtcgcc cgggtcccac cgccgccacc     atg cct cgg gga agc cgc agc     111
                                      Met Pro Arg Gly Ser Arg Ser
                                        1               5

 gcg gcc tcc cgg cca gcc agc cgc ccc gcc gcg ccc tct gcc cac ccg      159
 Ala Ala Ser Arg Pro Ala Ser Arg Pro Ala Ala Pro Ser Ala His Pro
          10                  15                  20

 ccc gcg cac cca ccg ccc tcg gca gcc gcc cca gcc ccc gcc cct tcg      207
 Pro Ala His Pro Pro Pro Ser Ala Ala Ala Pro Ala Pro Ala Pro Ser
      25                  30                  35

 ggc cag ccg ggg ctc atg gct cag atg gcg acc acg gcc gca ggg gta      255
 Gly Gln Pro Gly Leu Met Ala Gln Met Ala Thr Thr Ala Ala Gly Val
  40                  45                  50                  55

 gcc gtg ggc tcg gct gtg gga cac gtc atg ggc agc gcc ctg acc gga      303
 Ala Val Gly Ser Ala Val Gly His Val Met Gly Ser Ala Leu Thr Gly
                  60                  65                  70

 gcc ttc agc ggg ggg agc tcg gag ccc tcc cag cct gct gtc cag cag      351
 Ala Phe Ser Gly Gly Ser Ser Glu Pro Ser Gln Pro Ala Val Gln Gln
              75                  80                  85

 gcc ccc acc ccc gct gcc ccc cag ccc ctg cag atg ggg ccc tgc gcc      399
 Ala Pro Thr Pro Ala Ala Pro Gln Pro Leu Gln Met Gly Pro Cys Ala
          90                  95                 100

 tat gag atc agg cag ttc ctg gac tgt tcc acc act cag agt gac ctg      447
 Tyr Glu Ile Arg Gln Phe Leu Asp Cys Ser Thr Thr Gln Ser Asp Leu
     105                 110                 115

 tcc ctg tgt gag ggc ttc agc gag gcc ctg aag cag tgc aag tac tac      495
 Ser Leu Cys Glu Gly Phe Ser Glu Ala Leu Lys Gln Cys Lys Tyr Tyr
 120                 125                 130                 135

 cat ggt ctg agc tcc ctg ccc tga agaggtcggt gcagactcgg gggccagtcc     549
 His Gly Leu Ser Ser Leu Pro 
                 140

 tgcacccacc tctacccctc gccgacagcc agaccacaac accagattgt acccagatag    609

 ctgggattgg aagtgaggag gtttctcacc ccacagataa cccaagacac aaatgtgcaa    669

 ttaaaagttt attttagacc acaaaaaaaa aaaa                                703




      <210> 389
      <211> 799
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(483)

      <400> 389
 gcacgagctt ccgtcggtcg gtccttgctt cctgcttcgc ctccgcgcct cgcgctatgg     60

 gacagagccc ccgatccgcc agcaccacct gaggatccag aaaccgcccc agcg  atg     117
                                                              Met
                                                                1

 gaa gag gat cag gag ctg gag agg aaa gca ata gaa gaa ctg ctt aag      165
 Glu Glu Asp Gln Glu Leu Glu Arg Lys Ala Ile Glu Glu Leu Leu Lys
               5                  10                  15

 gag gca aaa cgt ggg aaa act aga gct gaa aca atg gga ccc atg ggt      213
 Glu Ala Lys Arg Gly Lys Thr Arg Ala Glu Thr Met Gly Pro Met Gly
          20                  25                  30

 tgg atg aag tgt cct ctt gct agc acc aat aaa aga ttt cta att aac      261
 Trp Met Lys Cys Pro Leu Ala Ser Thr Asn Lys Arg Phe Leu Ile Asn
      35                  40                  45

 aca att aaa aac aca ttg ccc tct cat aaa gag caa gac cat gaa caa      309
 Thr Ile Lys Asn Thr Leu Pro Ser His Lys Glu Gln Asp His Glu Gln
  50                  55                  60                  65

 aaa gag ggc gat aag gaa cca gcg aag agc cag gcc cag aaa gaa gaa      357
 Lys Glu Gly Asp Lys Glu Pro Ala Lys Ser Gln Ala Gln Lys Glu Glu
                  70                  75                  80

 aac ccg aag aaa cac aga agc cat cct tac aag cac agc ttc cgc gct      405
 Asn Pro Lys Lys His Arg Ser His Pro Tyr Lys His Ser Phe Arg Ala
              85                  90                  95

 cga ggt tcc gcc agt tac tcc ccg cca cga aag cgg agc agc cag gac      453
 Arg Gly Ser Ala Ser Tyr Ser Pro Pro Arg Lys Arg Ser Ser Gln Asp
         100                 105                 110

 aag tac gaa aag cgg tcc aac cgg cgg tga g gctggaacca gggccagcca      504
 Lys Tyr Glu Lys Arg Ser Asn Arg Arg 
     115                 120

 gccctgcggg cctccgtgct ccttcggggt gcggtgtgcg gagaaggcct gagctggcag    564

 ggcaaacacc tgagagtgac tttgacatta ggtcctttgt tgtttttaaa gaggctgctg    624

 gccacaggca aaaaaaatga cctagcaact cttgaggaaa caagtgcaaa ggaggatgtc    684

 ttggcaagtt taagctactt ctgcagtgta gtagacttac atattgttgt ttatcttgtt    744

 tggaagtgtg tttcaaaata aacatgtcta gaatttaaag ttttcaaaaa aaaaa         799




      <210> 390
      <211> 3323
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (300)..(2642)

      <400> 390
 tttcgtggcg cggctggtgc gcttgagaag cgatggcggc ggcctgaact cacctaacac     60

 cgcagcagca accgggcccg gccaggttcg gcgttccgtg agtgaacgat ttagaaatct    120

 ggactggcca gtgacctctg ggcttgccat tccagcctgg tataacctct ggctccatgg    180

 gcagctactg gctcctacag accggatgaa gcagactgga gacacaagtg gagaaaacct    240

 ccagctggca aatcctcaga gtgtaggcct ctggctgcca gtcctgccca gcctgcctc     299                                                                 
 atg gag agg atg aat tgg ctg agc aga ctg gcc tcc cgg ggc cct ggg      347
 Met Glu Arg Met Asn Trp Leu Ser Arg Leu Ala Ser Arg Gly Pro Gly
   1               5                  10                  15

 cac cgt ata cct caa ggg gcc aat ctc caa acc cca gtc atg gct gat      395
 His Arg Ile Pro Gln Gly Ala Asn Leu Gln Thr Pro Val Met Ala Asp
              20                  25                  30

 ccc gag acc tgc ctc atg gtc ttc aag aat cac tgg tcc cag gtg gtg      443
 Pro Glu Thr Cys Leu Met Val Phe Lys Asn His Trp Ser Gln Val Val
          35                  40                  45

 cga atc ctg gag cgg caa ggc cct cgg gca gct cct ggg ggt gca gac      491
 Arg Ile Leu Glu Arg Gln Gly Pro Arg Ala Ala Pro Gly Gly Ala Asp
      50                  55                  60

 gat ctc agt gct gtg cgc aac cac act tac cag atg ttg aca ctg ctg      539
 Asp Leu Ser Ala Val Arg Asn His Thr Tyr Gln Met Leu Thr Leu Leu
  65                  70                  75                  80

 gca gag gac cgt gca gtt ccc tcg gcc ccc aca ggc cct ggg ccc ctg      587
 Ala Glu Asp Arg Ala Val Pro Ser Ala Pro Thr Gly Pro Gly Pro Leu
                  85                  90                  95

 ctg gag ttt gct ctg cac gag gat ctg ctg acc cgt gtg ttg aca tgg      635
 Leu Glu Phe Ala Leu His Glu Asp Leu Leu Thr Arg Val Leu Thr Trp
             100                 105                 110

 cag ctg caa tgg gat gag ctt ggg gat ggg gtc gag gaa cgg cgg gct      683
 Gln Leu Gln Trp Asp Glu Leu Gly Asp Gly Val Glu Glu Arg Arg Ala
         115                 120                 125

 gag caa ctg aaa cta ttt gaa atg cta gtg agc gaa gct cgc cag cca      731
 Glu Gln Leu Lys Leu Phe Glu Met Leu Val Ser Glu Ala Arg Gln Pro
     130                 135                 140

 ctg ttg cgg cat ggt cca gtt cgt gag gct ctg ctc acc ctg ctg gat      779
 Leu Leu Arg His Gly Pro Val Arg Glu Ala Leu Leu Thr Leu Leu Asp
 145                 150                 155                 160

 gcc tgt ggc cgc cct gtg ccc agt agc cca gca ctg gat gaa ggc ttg      827
 Ala Cys Gly Arg Pro Val Pro Ser Ser Pro Ala Leu Asp Glu Gly Leu
                 165                 170                 175

 gtg cta ctt ctc agc cag ctg tgt gtt tgt gtg gcc cag gag cct tca      875
 Val Leu Leu Leu Ser Gln Leu Cys Val Cys Val Ala Gln Glu Pro Ser
             180                 185                 190

 ttg ctc gag ttc ttc ctg cag cca cct cct gag cct gga gcc gct ccc      923
 Leu Leu Glu Phe Phe Leu Gln Pro Pro Pro Glu Pro Gly Ala Ala Pro
         195                 200                 205

 cgt ctt ctt ctc ttt tct cgc ctt gtc cct ttt gtg cat cga gag ggc      971
 Arg Leu Leu Leu Phe Ser Arg Leu Val Pro Phe Val His Arg Glu Gly
     210                 215                 220

 acc ctg ggc cag cag gcc cgt gat gcc cta ctt ctt ctc atg gct ttg     1019
 Thr Leu Gly Gln Gln Ala Arg Asp Ala Leu Leu Leu Leu Met Ala Leu
 225                 230                 235                 240

 tca gct ggg agc ccc act gtg ggc cgc tac atc gcg gat cac tct tac     1067
 Ser Ala Gly Ser Pro Thr Val Gly Arg Tyr Ile Ala Asp His Ser Tyr
                 245                 250                 255

 ttc tgc ccg gtg ctg gcc aca ggg ctc agt gcc ctg tac tca tca ctg     1115
 Phe Cys Pro Val Leu Ala Thr Gly Leu Ser Ala Leu Tyr Ser Ser Leu
             260                 265                 270

 cct cga aag att gag gtt cca ggg gat gat tgg cac tgt ctg cga cgg     1163
 Pro Arg Lys Ile Glu Val Pro Gly Asp Asp Trp His Cys Leu Arg Arg
         275                 280                 285

 gaa gac tgg ctg gga gtg cca gcc ctt gca ctc ttc atg agt tcc ctg     1211
 Glu Asp Trp Leu Gly Val Pro Ala Leu Ala Leu Phe Met Ser Ser Leu
     290                 295                 300

 gag ttc tgc aat gca gta att cag gtg gct cac ccc ctg gtg cag aag     1259
 Glu Phe Cys Asn Ala Val Ile Gln Val Ala His Pro Leu Val Gln Lys
 305                 310                 315                 320

 cag ttg gtt gat tat atc cat aat ggg ttc ctg gtg cct gtc atg ggt     1307
 Gln Leu Val Asp Tyr Ile His Asn Gly Phe Leu Val Pro Val Met Gly
                 325                 330                 335

 cct gcc ttg cac aag acc tct gtg gag gag atg atc gcc agt acc gcc     1355
 Pro Ala Leu His Lys Thr Ser Val Glu Glu Met Ile Ala Ser Thr Ala
             340                 345                 350

 tac ctg gaa ctt ttc cta cgg agt atc tca gag cct gct ttg ctc cgt     1403
 Tyr Leu Glu Leu Phe Leu Arg Ser Ile Ser Glu Pro Ala Leu Leu Arg
         355                 360                 365

 acc ttc ctg cga ttc ctg ttg ttg cac cgg cat gac acc cac acc atc     1451
 Thr Phe Leu Arg Phe Leu Leu Leu His Arg His Asp Thr His Thr Ile
     370                 375                 380

 ctc gac acc ctc gtt gct cgt att ggc agt aac tcc cgg ctc tgc atg     1499
 Leu Asp Thr Leu Val Ala Arg Ile Gly Ser Asn Ser Arg Leu Cys Met
 385                 390                 395                 400

 gtc tct ctg agt ctc ttc agg acc ctc ctg aac ctc agc tgt gag gat     1547
 Val Ser Leu Ser Leu Phe Arg Thr Leu Leu Asn Leu Ser Cys Glu Asp
                 405                 410                 415

 gtc ctg ctg cag ctg gtt ctc agg tat ctt gtt cca tgt aac cac gtt     1595
 Val Leu Leu Gln Leu Val Leu Arg Tyr Leu Val Pro Cys Asn His Val
             420                 425                 430

 atg ctg agc cag aag ccg gct gtt cgt gat gtg gac cta tat gga cga     1643
 Met Leu Ser Gln Lys Pro Ala Val Arg Asp Val Asp Leu Tyr Gly Arg
         435                 440                 445

 gca gct gac aag ttt ctc tcc cta atc cca cgc tgt tgt cgg cac cac     1691
 Ala Ala Asp Lys Phe Leu Ser Leu Ile Pro Arg Cys Cys Arg His His
     450                 455                 460

 gcc ccc agc cca cct cgt cca gag cat gcc tca tgg gca cga ggt cct     1739
 Ala Pro Ser Pro Pro Arg Pro Glu His Ala Ser Trp Ala Arg Gly Pro
 465                 470                 475                 480

 gga agc cca agt gtg gac tcc tct tct gtg acg aca gta ccc cgg ccc     1787
 Gly Ser Pro Ser Val Asp Ser Ser Ser Val Thr Thr Val Pro Arg Pro
                 485                 490                 495

 tcc aca cca tct cgt ctg gct ctc ttc ctg cgg cag cag agc ctg ggt     1835
 Ser Thr Pro Ser Arg Leu Ala Leu Phe Leu Arg Gln Gln Ser Leu Gly
             500                 505                 510

 ggc tct gag tct cca ggc cca gcc cct tgc tca cca ggg ctt tct gca     1883
 Gly Ser Glu Ser Pro Gly Pro Ala Pro Cys Ser Pro Gly Leu Ser Ala
         515                 520                 525

 tcc ccc gcc tcc agc cct ggc cga cgg cct acc cct gca gag gag cct     1931
 Ser Pro Ala Ser Ser Pro Gly Arg Arg Pro Thr Pro Ala Glu Glu Pro
     530                 535                 540

 gga gag ctg gaa gac aat tac ctg gag tat ctg cgt gag gca cgt cgt     1979
 Gly Glu Leu Glu Asp Asn Tyr Leu Glu Tyr Leu Arg Glu Ala Arg Arg
 545                 550                 555                 560

 ggt gtg gac cgc tgt gtc cga gcc tgc cgt acc tgg tct gcc ccc tat     2027
 Gly Val Asp Arg Cys Val Arg Ala Cys Arg Thr Trp Ser Ala Pro Tyr
                 565                 570                 575

 gat ggc gag cgg ccc tct cct gag ccc agt cct ttt ggc tcc cgg act     2075
 Asp Gly Glu Arg Pro Ser Pro Glu Pro Ser Pro Phe Gly Ser Arg Thr
             580                 585                 590

 aag aaa cgc agc cta ctg cct gag gag gac agg aac aac gtg ggg gaa     2123
 Lys Lys Arg Ser Leu Leu Pro Glu Glu Asp Arg Asn Asn Val Gly Glu
         595                 600                 605

 ggg gag gag gaa gag ctg ggg agg agg ggg cgg gct ggg ggt gca ggg     2171
 Gly Glu Glu Glu Glu Leu Gly Arg Arg Gly Arg Ala Gly Gly Ala Gly
     610                 615                 620

 gag ggc cct ggt cac ctg ccc cct ccc cag ctc aat gga gtg cca gga     2219
 Glu Gly Pro Gly His Leu Pro Pro Pro Gln Leu Asn Gly Val Pro Gly
 625                 630                 635                 640

 tca tgg cct gag ggg gcc aag aag gtt cgt ctg gtg cca aag gag gga     2267
 Ser Trp Pro Glu Gly Ala Lys Lys Val Arg Leu Val Pro Lys Glu Gly
                 645                 650                 655

 gct ggg gaa ctg cta gag ggc atc tcc gag ggc atg gca gga cta gag     2315
 Ala Gly Glu Leu Leu Glu Gly Ile Ser Glu Gly Met Ala Gly Leu Glu
             660                 665                 670

 ggc ttt ggg cag gag ctc cgg gag cta gag gtg gca ttg agc aat ggg     2363
 Gly Phe Gly Gln Glu Leu Arg Glu Leu Glu Val Ala Leu Ser Asn Gly
         675                 680                 685

 gga act ggc tca gag tcc ccc tta gaa cct cca ctg ccc ctt gag gag     2411
 Gly Thr Gly Ser Glu Ser Pro Leu Glu Pro Pro Leu Pro Leu Glu Glu
     690                 695                 700

 gag gag gcc tac gag agc ttc acc tgt ccc cct gag ccc cct ggc ccc     2459
 Glu Glu Ala Tyr Glu Ser Phe Thr Cys Pro Pro Glu Pro Pro Gly Pro
 705                 710                 715                 720

 ttc ctc agc agc cct ttg cgg act ctc aac cag ctg cca agc cag ccc     2507
 Phe Leu Ser Ser Pro Leu Arg Thr Leu Asn Gln Leu Pro Ser Gln Pro
                 725                 730                 735

 ttc act ggc ccc ttc atg gct gtg ctc ttt gcc aaa ctc gag aac atg     2555
 Phe Thr Gly Pro Phe Met Ala Val Leu Phe Ala Lys Leu Glu Asn Met
             740                 745                 750

 ctg cag aac tcc gct ctt tcc tgc tca aca cca aca tgg tct tcc agc     2603
 Leu Gln Asn Ser Ala Leu Ser Cys Ser Thr Pro Thr Trp Ser Ser Ser
         755                 760                 765

 cca gtg tca agt ccc tgc tgc agg tgc tgg gct ctg tga agaataagat      2652
 Pro Val Ser Ser Pro Cys Cys Arg Cys Trp Ala Leu 
     770                 775                 780

 tgagaacttt gcggcttccc aggaggactt cccagcactg ctgtccaaag ccaagaagta   2712

 cctcattgcc cgtggcaagt tggactgggc tgagggccct gcagcaggac ctgccccacg   2772

 ccgttctgat cccctagtga agagccggag gccatccttg ggggagttac tcctgcggca   2832

 tgcacacagt ccaaccaggg cccggcaggc ggcacaattg gtccttcagc ctgggcgaga   2892

 cggagcagga cttggcctaa gtgggggctc ccctggggct tcaactccag ttctactcac   2952

 ccggggcggg gcccctgaac gccaaggtga ggctcttcga gtcaagaatg ctgtctactg   3012

 tgcagtcatt ttccctgaat ttctcaagga gttggctgcc atctcccagg ctcatgccgt   3072

 cacctcgcct ttcttgttgg agacttcaga ggaaggatct ggccctctca tctcaggctg   3132

 tgggcccctc aatccttaac tttcttccat ggacaatcag ggccatgggt ggcccgggct   3192

 ggggctaggg cacaggctcc tttttatgtt tggaggcagt ggcaaaagga ctttttaatt   3252

 tatttcagat gaatgtttta tggagaactt gttgcaatat gtataaaagg gaaatctcta   3312

 aaaaaaaaaa a                                                        3323




      <210> 391
      <211> 3365
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (300)..(2684)

      <400> 391
 tttcgtggcg cggctggtgc gcttgagaag cgatggcggc ggcctgaact cacctaacac     60

 cgcagcagca accgggcccg gccaggttcg gcgttccgtg agtgaacgat ttagaaatct    120

 ggactggcca gtgacctctg ggcttgccat tccagcctgg tataacctct ggctccatgg    180

 gcagctactg gctcctacag accggatgaa gcagactgga gacacaagtg gagaaaacct    240

 ccagctggca aatcctcaga gtgtaggcct ctggctgcca gtcctgccca gcctgcctc     299                                                                 
 atg gag agg atg aat tgg ctg agc aga ctg gcc tcc cgg ggc cct ggg      347
 Met Glu Arg Met Asn Trp Leu Ser Arg Leu Ala Ser Arg Gly Pro Gly
   1               5                  10                  15

 cac cgt ata cct caa ggg gcc aat ctc caa acc cca gtc atg gct gat      395
 His Arg Ile Pro Gln Gly Ala Asn Leu Gln Thr Pro Val Met Ala Asp
              20                  25                  30

 ccc gag acc tgc ctc atg gtc ttc aag aat cac tgg tcc cag gtg gtg      443
 Pro Glu Thr Cys Leu Met Val Phe Lys Asn His Trp Ser Gln Val Val
          35                  40                  45

 cga atc ctg gag cgg caa ggc cct cgg gca gct cct ggg ggt gca gac      491
 Arg Ile Leu Glu Arg Gln Gly Pro Arg Ala Ala Pro Gly Gly Ala Asp
      50                  55                  60

 gat ctc agt gct gtg cgc aac cac act tac cag atg ttg aca ctg ctg      539
 Asp Leu Ser Ala Val Arg Asn His Thr Tyr Gln Met Leu Thr Leu Leu
  65                  70                  75                  80

 gca gag gac cgt gca gtt ccc tcg gcc ccc aca ggc cct ggg ccc ctg      587
 Ala Glu Asp Arg Ala Val Pro Ser Ala Pro Thr Gly Pro Gly Pro Leu
                  85                  90                  95

 ctg gag ttt gct ctg cac gag gat ctg ctg acc cgt gtg ttg aca tgg      635
 Leu Glu Phe Ala Leu His Glu Asp Leu Leu Thr Arg Val Leu Thr Trp
             100                 105                 110

 cag ctg caa tgg gat gag ctt ggg gat ggg gtc gag gaa cgg cgg gct      683
 Gln Leu Gln Trp Asp Glu Leu Gly Asp Gly Val Glu Glu Arg Arg Ala
         115                 120                 125

 gag caa ctg aaa cta ttt gaa atg cta gtg agc gaa gct cgc cag cca      731
 Glu Gln Leu Lys Leu Phe Glu Met Leu Val Ser Glu Ala Arg Gln Pro
     130                 135                 140

 ctg ttg cgg cat ggt cca gtt cgt gag gct ctg ctc acc ctg ctg gat      779
 Leu Leu Arg His Gly Pro Val Arg Glu Ala Leu Leu Thr Leu Leu Asp
 145                 150                 155                 160

 gcc tgt ggc cgc cct gtg ccc agt agc cca gca ctg gat gaa ggc ttg      827
 Ala Cys Gly Arg Pro Val Pro Ser Ser Pro Ala Leu Asp Glu Gly Leu
                 165                 170                 175

 gtg cta ctt ctc agc cag ctg tgt gtt tgt gtg gcc cag gag cct tca      875
 Val Leu Leu Leu Ser Gln Leu Cys Val Cys Val Ala Gln Glu Pro Ser
             180                 185                 190

 ttg ctc gag ttc ttc ctg cag cca cct cct gag cct gga gcc gct ccc      923
 Leu Leu Glu Phe Phe Leu Gln Pro Pro Pro Glu Pro Gly Ala Ala Pro
         195                 200                 205

 cgt ctt ctt ctc ttt tct cgc ctt gtc cct ttt gtg cat cga gag ggc      971
 Arg Leu Leu Leu Phe Ser Arg Leu Val Pro Phe Val His Arg Glu Gly
     210                 215                 220

 acc ctg ggc cag cag gcc cgt gat gcc cta ctt ctt ctc atg gct ttg     1019
 Thr Leu Gly Gln Gln Ala Arg Asp Ala Leu Leu Leu Leu Met Ala Leu
 225                 230                 235                 240

 tca gct ggg agc ccc act gtg ggc cgc tac atc gcg gat cac tct tac     1067
 Ser Ala Gly Ser Pro Thr Val Gly Arg Tyr Ile Ala Asp His Ser Tyr
                 245                 250                 255

 ttc tgc ccg gtg ctg gcc aca ggg ctc agt gcc ctg tac tca tca ctg     1115
 Phe Cys Pro Val Leu Ala Thr Gly Leu Ser Ala Leu Tyr Ser Ser Leu
             260                 265                 270

 cct cga aag att gag gtt cca ggg gat gat tgg cac tgt ctg cga cgg     1163
 Pro Arg Lys Ile Glu Val Pro Gly Asp Asp Trp His Cys Leu Arg Arg
         275                 280                 285

 gaa gac tgg ctg gga gtg cca gcc ctt gca ctc ttc atg agt tcc ctg     1211
 Glu Asp Trp Leu Gly Val Pro Ala Leu Ala Leu Phe Met Ser Ser Leu
     290                 295                 300

 gag ttc tgc aat gca gta att cag gtg gct cac ccc ctg gtg cag aag     1259
 Glu Phe Cys Asn Ala Val Ile Gln Val Ala His Pro Leu Val Gln Lys
 305                 310                 315                 320

 cag ttg gtt gat tat atc cat aat ggg ttc ctg gtg cct gtc atg ggt     1307
 Gln Leu Val Asp Tyr Ile His Asn Gly Phe Leu Val Pro Val Met Gly
                 325                 330                 335

 cct gcc ttg cac aag acc tct gtg gag gag atg atc gcc agt acc gcc     1355
 Pro Ala Leu His Lys Thr Ser Val Glu Glu Met Ile Ala Ser Thr Ala
             340                 345                 350

 tac ctg gaa ctt ttc cta cgg agt atc tca gag cct gct ttg ctc cgt     1403
 Tyr Leu Glu Leu Phe Leu Arg Ser Ile Ser Glu Pro Ala Leu Leu Arg
         355                 360                 365

 acc ttc ctg cga ttc ctg ttg ttg cac cgg cat gac acc cac acc atc     1451
 Thr Phe Leu Arg Phe Leu Leu Leu His Arg His Asp Thr His Thr Ile
     370                 375                 380

 ctc gac acc ctc gtt gct cgt att ggc agt aac tcc cgg ctc tgc atg     1499
 Leu Asp Thr Leu Val Ala Arg Ile Gly Ser Asn Ser Arg Leu Cys Met
 385                 390                 395                 400

 gtc tct ctg agt ctc ttc agg acc ctc ctg aac ctc agc tgt gag gat     1547
 Val Ser Leu Ser Leu Phe Arg Thr Leu Leu Asn Leu Ser Cys Glu Asp
                 405                 410                 415

 gtc ctg ctg cag ctg gtt ctc agg tat ctt gtt cca tgt aac cac gtt     1595
 Val Leu Leu Gln Leu Val Leu Arg Tyr Leu Val Pro Cys Asn His Val
             420                 425                 430

 atg ctg agc cag aag ccg gct gtt cgt gat gtg gac cta tat gga cga     1643
 Met Leu Ser Gln Lys Pro Ala Val Arg Asp Val Asp Leu Tyr Gly Arg
         435                 440                 445

 gca gct gac aag ttt ctc tcc cta atc cca cgc tgt tgt cgg cac cac     1691
 Ala Ala Asp Lys Phe Leu Ser Leu Ile Pro Arg Cys Cys Arg His His
     450                 455                 460

 gcc ccc agc cca cct cgt cca gag cat gcc tca tgg gca cga ggt ggg     1739
 Ala Pro Ser Pro Pro Arg Pro Glu His Ala Ser Trp Ala Arg Gly Gly
 465                 470                 475                 480

 cct agc aga gag aca ggg aga agg gag gac atc acg ggt cct gga agc     1787
 Pro Ser Arg Glu Thr Gly Arg Arg Glu Asp Ile Thr Gly Pro Gly Ser
                 485                 490                 495

 cca agt gtg gac tcc tct tct gtg acg aca gta ccc cgg ccc tcc aca     1835
 Pro Ser Val Asp Ser Ser Ser Val Thr Thr Val Pro Arg Pro Ser Thr
             500                 505                 510

 cca tct cgt ctg gct ctc ttc ctg cgg cag cag agc ctg ggt ggc tct     1883
 Pro Ser Arg Leu Ala Leu Phe Leu Arg Gln Gln Ser Leu Gly Gly Ser
         515                 520                 525

 gag tct cca ggc cca gcc cct tgc tca cca ggg ctt tct gca tcc ccc     1931
 Glu Ser Pro Gly Pro Ala Pro Cys Ser Pro Gly Leu Ser Ala Ser Pro
     530                 535                 540

 gcc tcc agc cct ggc cga cgg cct acc cct gca gag gag cct gga gag     1979
 Ala Ser Ser Pro Gly Arg Arg Pro Thr Pro Ala Glu Glu Pro Gly Glu
 545                 550                 555                 560

 ctg gaa gac aat tac ctg gag tat ctg cgt gag gca cgt cgt ggt gtg     2027
 Leu Glu Asp Asn Tyr Leu Glu Tyr Leu Arg Glu Ala Arg Arg Gly Val
                 565                 570                 575

 gac cgc tgt gtc cga gcc tgc cgt acc tgg tct gcc ccc tat gat ggc     2075
 Asp Arg Cys Val Arg Ala Cys Arg Thr Trp Ser Ala Pro Tyr Asp Gly
             580                 585                 590

 gag cgg ccc tct cct gag ccc agt cct ttt ggc tcc cgg act aag aaa     2123
 Glu Arg Pro Ser Pro Glu Pro Ser Pro Phe Gly Ser Arg Thr Lys Lys
         595                 600                 605

 cgc agc cta ctg cct gag gag gac agg aac aac gtg ggg gaa ggg gag     2171
 Arg Ser Leu Leu Pro Glu Glu Asp Arg Asn Asn Val Gly Glu Gly Glu
     610                 615                 620

 gag gaa gag ctg ggg agg agg ggg cgg gct ggg ggt gca ggg gag ggc     2219
 Glu Glu Glu Leu Gly Arg Arg Gly Arg Ala Gly Gly Ala Gly Glu Gly
 625                 630                 635                 640

 cct ggt cac ctg ccc cct ccc cag ctc aat gga gtg cca gga tca tgg     2267
 Pro Gly His Leu Pro Pro Pro Gln Leu Asn Gly Val Pro Gly Ser Trp
                 645                 650                 655

 cct gag ggg gcc aag aag gtt cgt ctg gtg cca aag gag gga gct ggg     2315
 Pro Glu Gly Ala Lys Lys Val Arg Leu Val Pro Lys Glu Gly Ala Gly
             660                 665                 670

 gaa ctg cta gag ggc atc tcc gag ggc atg gca gga cta gag ggc ttt     2363
 Glu Leu Leu Glu Gly Ile Ser Glu Gly Met Ala Gly Leu Glu Gly Phe
         675                 680                 685

 ggg cag gag ctc cgg gag cta gag gtg gca ttg agc aat ggg gga act     2411
 Gly Gln Glu Leu Arg Glu Leu Glu Val Ala Leu Ser Asn Gly Gly Thr
     690                 695                 700

 ggc tca gag tcc ccc tta gaa cct cca ctg ccc ctt gag gag gag gag     2459
 Gly Ser Glu Ser Pro Leu Glu Pro Pro Leu Pro Leu Glu Glu Glu Glu
 705                 710                 715                 720

 gcc tac gag agc ttc acc tgt ccc cct gag ccc cct ggc ccc ttc ctc     2507
 Ala Tyr Glu Ser Phe Thr Cys Pro Pro Glu Pro Pro Gly Pro Phe Leu
                 725                 730                 735

 agc agc cct ttg cgg act ctc aac cag ctg cca agc cag ccc ttc act     2555
 Ser Ser Pro Leu Arg Thr Leu Asn Gln Leu Pro Ser Gln Pro Phe Thr
             740                 745                 750

 ggc ccc ttc atg gct gtg ctc ttt gcc aaa ctc gag aac atg ctg cag     2603
 Gly Pro Phe Met Ala Val Leu Phe Ala Lys Leu Glu Asn Met Leu Gln
         755                 760                 765

 aac tcc gct ctt tcc tgc tca aca cca aca tgg tct tcc agc cca gtg     2651
 Asn Ser Ala Leu Ser Cys Ser Thr Pro Thr Trp Ser Ser Ser Pro Val
     770                 775                 780

 tca agt ccc tgc tgc agg tgc tgg gct ctg tga agaataag attgagaact     2702
 Ser Ser Pro Cys Cys Arg Cys Trp Ala Leu 
 785                 790

 ttgcggcttc ccaggaggac ttcccagcac tgctgtccaa agccaagaag tacctcattg   2762

 cccgtggcaa gttggactgg gctgagggcc ctgcagcagg acctgcccca cgccgttctg   2822

 atcccctagt gaagagccgg aggccatcct tgggggagtt actcctgcgg catgcacaca   2882

 gtccaaccag ggcccggcag gcggcacaat tggtccttca gcctgggcga gacggagcag   2942

 gacttggcct aagtgggggc tcccctgggg cttcaactcc agttctactc acccggggcg   3002

 gggcccctga acgccaaggt gaggctcttc gagtcaagaa tgctgtctac tgtgcagtca   3062

 ttttccctga atttctcaag gagttggctg ccatctccca ggctcatgcc gtcacctcgc   3122

 ctttcttgtt ggagacttca gaggaaggat ctggccctct catctcaggc tgtgggcccc   3182

 tcaatcctta actttcttcc atggacaatc agggccatgg gtggcccggg ctggggctag   3242

 ggcacaggct cctttttatg tttggaggca gtggcaaaag gactttttaa tttatttcag   3302

 atgaatgttt tatggagaac ttgttgcaat atgtataaaa gggaaatctc taaaaaaaaa   3362

 aaa                                                                 3365




      <210> 392
      <211> 461
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (117)..(410)

      <400> 392
 agcacagaga gaatacttcg agctcatgct gagagaaaaa ggccagcttg tcttttctta     60

 cctgacactg ggcctgaagg gagagattca gttcttcatt gacgggagct ttcaag        116                                                                 
 atg tac ctg gga att aca cca agt gtg acc tgt aac aat tca agc aaa      164
 Met Tyr Leu Gly Ile Thr Pro Ser Val Thr Cys Asn Asn Ser Ser Lys
   1               5                  10                  15

 aat gaa ttt tcc ctg att cta gag aag aat ccc ctg gtg gag ttt gtg      212
 Asn Glu Phe Ser Leu Ile Leu Glu Lys Asn Pro Leu Val Glu Phe Val
              20                  25                  30

 gaa gag ctc cct gct ggg cga tct tct ctg tgc tac tgc aac ttg ctc      260
 Glu Glu Leu Pro Ala Gly Arg Ser Ser Leu Cys Tyr Cys Asn Leu Leu
          35                  40                  45

 tgt ggg att atc aga ggt gcc ttg gaa atg gtt cat ttg gcg gct gat      308
 Cys Gly Ile Ile Arg Gly Ala Leu Glu Met Val His Leu Ala Ala Asp
      50                  55                  60

 gtt aca ttc ttg caa gac aga cta aaa ggt gac agt gtg aca gaa ata      356
 Val Thr Phe Leu Gln Asp Arg Leu Lys Gly Asp Ser Val Thr Glu Ile
  65                  70                  75                  80

 gga ata aca ttt cta aaa aag cga gac gag aaa aaa tat aga ggg aaa      404
 Gly Ile Thr Phe Leu Lys Lys Arg Asp Glu Lys Lys Tyr Arg Gly Lys
                  85                  90                  95

 aaa tga agactagcac ggaaaatgcc acggggcggc tagctgagtt aatgttagct       460
 Lys 


 a                                                                    461




      <210> 393
      <211> 625
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (53)..(625)

      <400> 393
 aggctccgtt tcctttctgt gagagaaggc ttttgtcttt cctcctgcta cg    atg      55
                                                              Met
                                                                1

 tca gtg tct ggc aag aaa gag ttt gat gtg aaa cag atc cta agg cta      103
 Ser Val Ser Gly Lys Lys Glu Phe Asp Val Lys Gln Ile Leu Arg Leu
               5                  10                  15

 cgc tgg agg tgg ttt agt cat cct ttt caa ggt tcc acc aac act gga      151
 Arg Trp Arg Trp Phe Ser His Pro Phe Gln Gly Ser Thr Asn Thr Gly
          20                  25                  30

 agc tgt ctt cag cag gaa gga tat gag cat aga ggg acc ccg gtt cag      199
 Ser Cys Leu Gln Gln Glu Gly Tyr Glu His Arg Gly Thr Pro Val Gln
      35                  40                  45

 ggc agg ttg aag agc cac tct cgg gac aga aac gga ctg aag aaa agc      247
 Gly Arg Leu Lys Ser His Ser Arg Asp Arg Asn Gly Leu Lys Lys Ser
  50                  55                  60                  65

 aac agt cct gtc cac cac aat ata ctg gca cca gtg cca gga ccg gcc      295
 Asn Ser Pro Val His His Asn Ile Leu Ala Pro Val Pro Gly Pro Ala
                  70                  75                  80

 cct gcc cat cag aga gcc gtt cag aat ttg cag caa cat aat ctg ata      343
 Pro Ala His Gln Arg Ala Val Gln Asn Leu Gln Gln His Asn Leu Ile
              85                  90                  95

 gta cat ttt caa gca aat gaa gat act cct aaa tca gtt cca gag aag      391
 Val His Phe Gln Ala Asn Glu Asp Thr Pro Lys Ser Val Pro Glu Lys
         100                 105                 110

 aat tta ttc aaa gaa gct tgt gag aaa cgc gca caa gat ttg gag atg      439
 Asn Leu Phe Lys Glu Ala Cys Glu Lys Arg Ala Gln Asp Leu Glu Met
     115                 120                 125

 atg gct gat gac aat ata gaa gat tct aca gca agg aaa aag gta atg      487
 Met Ala Asp Asp Asn Ile Glu Asp Ser Thr Ala Arg Lys Lys Val Met
 130                 135                 140                 145

 aag cag aga agt tta atg tat act cca atg gaa gac ttc agt ttt gtc      535
 Lys Gln Arg Ser Leu Met Tyr Thr Pro Met Glu Asp Phe Ser Phe Val
                 150                 155                 160

 gaa atg aaa gac ata tat tgg aga aga cta caa aat gag gag acc aaa      583
 Glu Met Lys Asp Ile Tyr Trp Arg Arg Leu Gln Asn Glu Glu Thr Lys
             165                 170                 175

 aaa gaa ggt tct caa aaa gtt cca ttt tac aag aaa att taa              625
 Lys Glu Gly Ser Gln Lys Val Pro Phe Tyr Lys Lys Ile 
         180                 185                 190





      <210> 394
      <211> 506
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (9)..(506)

      <400> 394
 tcgccaag atg gac tcc tcg cgg gcc cga cag cag ctc cgg cgg cga ttc      50
          Met Asp Ser Ser Arg Ala Arg Gln Gln Leu Arg Arg Arg Phe
            1               5                  10

 ctc ctc ctg ccg gac gcc gag gcc cag ctg gat cgc gag ggt gac gcc       98
 Leu Leu Leu Pro Asp Ala Glu Ala Gln Leu Asp Arg Glu Gly Asp Ala
  15                  20                  25                  30

 ggg ccg gaa acc tcc aca gct gtt gag aaa aag gag aaa cct ctt cca      146
 Gly Pro Glu Thr Ser Thr Ala Val Glu Lys Lys Glu Lys Pro Leu Pro
                  35                  40                  45

 aga ctt aat atc cat tct gga ttc tgg att ttg gca tcc att gtt gtg      194
 Arg Leu Asn Ile His Ser Gly Phe Trp Ile Leu Ala Ser Ile Val Val
              50                  55                  60

 acc tat tat gtt gac ttc ttt aaa acc ctt aaa gaa aac ttc cac act      242
 Thr Tyr Tyr Val Asp Phe Phe Lys Thr Leu Lys Glu Asn Phe His Thr
          65                  70                  75

 agc agc tgg ttt ctc tgt ggc agt gcc ttg ttg ctt gtc agt tta tca      290
 Ser Ser Trp Phe Leu Cys Gly Ser Ala Leu Leu Leu Val Ser Leu Ser
      80                  85                  90

 att gca ttt tac tgc ata gtc tac ctg gaa tgg tat tgt gga att gga      338
 Ile Ala Phe Tyr Cys Ile Val Tyr Leu Glu Trp Tyr Cys Gly Ile Gly
  95                 100                 105                 110

 gaa tat gat gtc aag tat cca gcc ttg ata ccc att acc act gcc tcc      386
 Glu Tyr Asp Val Lys Tyr Pro Ala Leu Ile Pro Ile Thr Thr Ala Ser
                 115                 120                 125

 ttt att gca gca gga att tgc ttc aac att gct tta tgg cat gtg tgg      434
 Phe Ile Ala Ala Gly Ile Cys Phe Asn Ile Ala Leu Trp His Val Trp
             130                 135                 140

 tcg ttt ttc act cca ttg ttg ttg ttt acc cag ttt atg ggg gtt gtc      482
 Ser Phe Phe Thr Pro Leu Leu Leu Phe Thr Gln Phe Met Gly Val Val
         145                 150                 155

 atg ttt atc aca ctc ctt gga tga                                      506
 Met Phe Ile Thr Leu Leu Gly 
     160                 165





      <210> 395
      <211> 340
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (225)..(293)

      <400> 395
 ccttcatttt tatttttgaa cttacctgcc tcacctcgtt atgtctttat cttattttta     60

 aacttactca gttcacccac tgtggaattg ggagtatatg gaagtattcc cacccccagt    120

 tttatatacc gccccagagc tgaccattct cgctcatttc ccctgggtcc tggccgactc    180

 gagtgtgcct ttccttccga tcctgctcca cacagatctg aggg atg ctg ccc ttt     236
                                                  Met Leu Pro Phe
                                                    1

 cct tct cca cct gcc cct ccc tca cat cca gcc cca cca gcc tac acg      284
 Pro Ser Pro Pro Ala Pro Pro Ser His Pro Ala Pro Pro Ala Tyr Thr
   5                  10                  15                  20

 tta gct taa ataggga gcttttacat tccccatgaa agggaatcca gggacaggct      340
 Leu Ala 






      <210> 396
      <211> 1430
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (318)..(1223)

      <400> 396
 cggacttgaa caaaaacaac tctttttcca tggtaccaat tataaaaaga atggctttgc     60

 actgagcagc tcagtctact ggtctcatca gtgaaaggct tgtgaaaatt tctggaaaga    120

 gcattggctg gcttgttcat ctctctgttt ggtcagttgc tgtgtttctg ccggatcaga    180

 tgagcagatt ggttagtgaa ggtcagtgtg agaagaagat tgtttctgag cttgagaagc    240

 ttctggagga ttgaagagta tttgaagtct gtgtcaaaca tccatatcat aagtggaatt    300

 ttggagatat tcaaaga   atg ctg tca gaa ggg tat ctc agt gga ctt gag     350
                      Met Leu Ser Glu Gly Tyr Leu Ser Gly Leu Glu
                        1               5                  10

 tac tgg aat gac atc cac tgg agt tgt gcc tct tat aat gag cag gtg      398
 Tyr Trp Asn Asp Ile His Trp Ser Cys Ala Ser Tyr Asn Glu Gln Val
              15                  20                  25

 gct ggg gaa aag gaa gag gag aca aat tct gtt gct acc ctt tcc tat      446
 Ala Gly Glu Lys Glu Glu Glu Thr Asn Ser Val Ala Thr Leu Ser Tyr
          30                  35                  40

 tcc tct gtg gat gaa aca caa gtc aga agt ctc tac gtg agc tgc aaa      494
 Ser Ser Val Asp Glu Thr Gln Val Arg Ser Leu Tyr Val Ser Cys Lys
      45                  50                  55

 tca tct ggc aag ttt atc tct tca gtg cat tca aga gag agc caa cat      542
 Ser Ser Gly Lys Phe Ile Ser Ser Val His Ser Arg Glu Ser Gln His
  60                  65                  70                  75

 agc aga agt cag aga gtc aca gtg ctg cag aca aac ccc aat cct gtg      590
 Ser Arg Ser Gln Arg Val Thr Val Leu Gln Thr Asn Pro Asn Pro Val
                  80                  85                  90

 ttt gaa agc cca aac ttg gct gca gtt gaa ata tgt aga gat gcc agc      638
 Phe Glu Ser Pro Asn Leu Ala Ala Val Glu Ile Cys Arg Asp Ala Ser
              95                 100                 105

 aga gag acc tac ttg gtt cca tct tct tgc aaa agt att tgc aag aat      686
 Arg Glu Thr Tyr Leu Val Pro Ser Ser Cys Lys Ser Ile Cys Lys Asn
         110                 115                 120

 tat aat gac tta cag att gca ggg ggc cag gtg atg gcc att aat tca      734
 Tyr Asn Asp Leu Gln Ile Ala Gly Gly Gln Val Met Ala Ile Asn Ser
     125                 130                 135

 gtg aca aca gat ttt ccc tct gag agc agt ttt gaa tat ggc cct ttg      782
 Val Thr Thr Asp Phe Pro Ser Glu Ser Ser Phe Glu Tyr Gly Pro Leu
 140                 145                 150                 155

 ctg aag tca tct gag att cct tta ccc atg gag gat tcc att tct act      830
 Leu Lys Ser Ser Glu Ile Pro Leu Pro Met Glu Asp Ser Ile Ser Thr
                 160                 165                 170

 cag ccc agt gac ttt ccc caa aaa cct atc cag cgg tac tca tcc tat      878
 Gln Pro Ser Asp Phe Pro Gln Lys Pro Ile Gln Arg Tyr Ser Ser Tyr
             175                 180                 185

 tgg aga ata aca agc atc aaa gag aaa agc agc ttg caa atg cag aat      926
 Trp Arg Ile Thr Ser Ile Lys Glu Lys Ser Ser Leu Gln Met Gln Asn
         190                 195                 200

 cct att tct aat gca gtg ctg aat gag tac ctg gag cag aag gtt gtg      974
 Pro Ile Ser Asn Ala Val Leu Asn Glu Tyr Leu Glu Gln Lys Val Val
     205                 210                 215

 gag tta tat aaa cag tac att atg gac acc gtg ttt cat gac agt tct     1022
 Glu Leu Tyr Lys Gln Tyr Ile Met Asp Thr Val Phe His Asp Ser Ser
 220                 225                 230                 235

 cct acc cag att ctg gcg tct gaa ctc atc atg aca agt gta gac caa     1070
 Pro Thr Gln Ile Leu Ala Ser Glu Leu Ile Met Thr Ser Val Asp Gln
                 240                 245                 250

 atc agt ctt caa gtg tct aga gag aag aat ctg gag acc tca aaa gcc     1118
 Ile Ser Leu Gln Val Ser Arg Glu Lys Asn Leu Glu Thr Ser Lys Ala
             255                 260                 265

 aga gat ata gtc ttt agc cgc cta ttg caa ttg atg tca act gaa att     1166
 Arg Asp Ile Val Phe Ser Arg Leu Leu Gln Leu Met Ser Thr Glu Ile
         270                 275                 280

 act gaa att agc act cct agt ctc cat att tct cag tat agc aat gta     1214
 Thr Glu Ile Ser Thr Pro Ser Leu His Ile Ser Gln Tyr Ser Asn Val
     285                 290                 295

 aat cca tag agaggat gcttccatta ctgtctcgca tttacttaaa catgaagcaa     1270
 Asn Pro 
 300

 cactttatcc atttattctg agaatgtgca ggaggggtta gtgaagggga attaagggct   1330

 agagaagtaa agatcagctg gaagtcatgt gtgaatcatg gagaaatctc ataatattac   1390

 acttgatgaa ggaatatggt aagaggagcc ataaggaatg                         1430




      <210> 397
      <211> 1832
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (684)..(1370)

      <400> 397
 ggaatcttgg aatttttata gacagcacct cagtttctga ctccagccgc acacctcctg     60

 cctctgccag caggggttgc cgccagacca gagccagggc caggtccctg cgtccatccc    120

 ccccggtagg atggacgtga gccatccttc taggggactt ttttcagtgt gcgactcgtc    180

 tctgttaggt ggtaggagcc agtttgtgtg gcctgtgcca cgctccacag tgcgtggctg    240

 ggctctgtgt gtggcctgtg tcccctgtcc ctgcaggacc cagcaggcat cgtggcgtga    300

 cagctgtgtc caagccactg cccgggcatc ccatcaccca ccagggtgca cggtctctcc    360

 tgctgggggc tttctgtcgc atgtgtgtct cctgtcgact ctgcagtttg ttctcagagc    420

 agaatgtttc ctgttctcag tgcacaaaga cactggtttt caatcggcgt ctaaaaccac    480

 gttcctgcct ttcattgcaa cacggtgtgt tcatttgttt aaaacagttt aatgagtaag    540

 tttagatgac tggtcaatat cttaaaaatg tatattagta agaagttctt cctggaattt    600

 ttctttcgat tctggcagaa taaacaggtg tttttagttt tcccactgtc tgagccaagc    660

 aggaccctgt cccagagcaa gag    atg tcc cct tcc atc tct gac cct tgc     710
                              Met Ser Pro Ser Ile Ser Asp Pro Cys
                                1               5

 ctg gga caa gct ttg atg ggg ggc ccc agc ttc aag gct gtg gtg gga      758
 Leu Gly Gln Ala Leu Met Gly Gly Pro Ser Phe Lys Ala Val Val Gly
  10                  15                  20                  25

 aca gca ccc cca aat gcc agc ctc tcc ttt ctt ccc atc cac cag tat      806
 Thr Ala Pro Pro Asn Ala Ser Leu Ser Phe Leu Pro Ile His Gln Tyr
                  30                  35                  40

 act gcg ggg cca ttt ctg gtc ttt gtc caa cag gaa acc cat ttc tgg      854
 Thr Ala Gly Pro Phe Leu Val Phe Val Gln Gln Glu Thr His Phe Trp
              45                  50                  55

 tgg gat atg cct tcc agt gcc aca ggg cca ctc acc cca tgc atc tct      902
 Trp Asp Met Pro Ser Ser Ala Thr Gly Pro Leu Thr Pro Cys Ile Ser
          60                  65                  70

 gtc ctg ccc gtc agt gct ggg acg gac agc aag ggc aag ccc agt gtc      950
 Val Leu Pro Val Ser Ala Gly Thr Asp Ser Lys Gly Lys Pro Ser Val
      75                  80                  85

 tgg cgg ata ggt ggg tgg gaa cag aga ggg gag aat gcc gtc cta agc      998
 Trp Arg Ile Gly Gly Trp Glu Gln Arg Gly Glu Asn Ala Val Leu Ser
  90                  95                 100                 105

 ttc tgc ttg ggg atc ccc cac acg acc tgg gta ctg cct ggg aaa cct     1046
 Phe Cys Leu Gly Ile Pro His Thr Thr Trp Val Leu Pro Gly Lys Pro
                 110                 115                 120

 gtc cta agt aaa act atg gac ctc gcc tcg ccc acc ggc ctg caa agc     1094
 Val Leu Ser Lys Thr Met Asp Leu Ala Ser Pro Thr Gly Leu Gln Ser
             125                 130                 135

 cag cat ctc cgt gaa ggt gga tgg aag cgc ctt tgt cct cat ttt gag     1142
 Gln His Leu Arg Glu Gly Gly Trp Lys Arg Leu Cys Pro His Phe Glu
         140                 145                 150

 ctg caa gct ggg tca gcg gct ctg aag ccc tcg agt gac ttt cta acc     1190
 Leu Gln Ala Gly Ser Ala Ala Leu Lys Pro Ser Ser Asp Phe Leu Thr
     155                 160                 165

 caa gac cca gcc cct ggc agg agg agg gtg ggt gca ggg ctg gtg gga     1238
 Gln Asp Pro Ala Pro Gly Arg Arg Arg Val Gly Ala Gly Leu Val Gly
 170                 175                 180                 185

 caa aaa gag gcc tca gca ggc ctg gaa gac cct tcc agt aca tcc cac     1286
 Gln Lys Glu Ala Ser Ala Gly Leu Glu Asp Pro Ser Ser Thr Ser His
                 190                 195                 200

 agc gtg tcg agc agc tgg gag aac ctg tgt caa gct cga gcc gtc ata     1334
 Ser Val Ser Ser Ser Trp Glu Asn Leu Cys Gln Ala Arg Ala Val Ile
             205                 210                 215

 ggt ccc cat gag gtg tct gaa gcc cct tct tgg tga tggg aggcagaggt     1384
 Gly Pro His Glu Val Ser Glu Ala Pro Ser Trp 
         220                 225

 gctgacgttc tggagcatgg acgtgagtcc tcagctggct ccgcgtgggc ccttggaggg   1444

 tgccaggtgt gtggtgacct tctggatgcc tttaacttca tggctgcgtc attcctgatt   1504

 tagaacttta accggagctt catctagtga ttgcaaaact ggaccaatgg gaggacggcg   1564

 gcgcagcccg ctccctccgt ggaatggagc tcagctcttc ggaggcatca aagcacctgt   1624

 cgcctccgtg gtccccctgc cgagggagtg cggcctctgc aaggttcggg ggtggcttcg   1684

 tttgcctgga gtggccggcc ctgcttgtgc catgtggatg tttgtgagcc tcggtcctac   1744

 agcactgtgt aggctgcatc tgtttcgtgc tggtcctgtt gacttgtatg atatccacaa   1804

 ataaatattt tcatggcgaa aaaaaaaa                                      1832




      <210> 398
      <211> 827
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (269)..(766)

      <400> 398
 tcgtgctggc tgattcttga gggtccccct gccacgctcc agccacgccc ctgcttacac     60

 accctaatgc cagccctgga ctctcttcct cgggagcccc tccttcaact ctgcagctcc    120

 tctcgcaccc agaggagctc ctttccccag caggcctcac tggtaggatc ctgaccatct    180

 tctccaaacc ttccccagga gagactctgc ctttagggtc atccaagtat ccctgctctc    240

 agaaccggag gtccactggt tttctata   atg tac tct ttc cct cct gcc aca     292
                                  Met Tyr Ser Phe Pro Pro Ala Thr
                                    1               5

 tcc tgc ccc ctt cac att cac gag tca tta cca gcc agg gaa ggt cat      340
 Ser Cys Pro Leu His Ile His Glu Ser Leu Pro Ala Arg Glu Gly His
      10                  15                  20

 cca agt ttc ctc cag cat ggg cga tat ctt tgg gac cga gac ttt cct      388
 Pro Ser Phe Leu Gln His Gly Arg Tyr Leu Trp Asp Arg Asp Phe Pro
  25                  30                  35                  40

 tgg aga gct gct gag agc gga cag tcc caa aaa caa gtg tca aag ggc      436
 Trp Arg Ala Ala Glu Ser Gly Gln Ser Gln Lys Gln Val Ser Lys Gly
                  45                  50                  55

 cca agg gaa agg gga ctg tgc cct gga ggc tca ctt cac agg gat cag      484
 Pro Arg Glu Arg Gly Leu Cys Pro Gly Gly Ser Leu His Arg Asp Gln
              60                  65                  70

 tgt ttg ctc cac agc tgt agc tct ggg ctg acg ccc ccc aga ccc ctt      532
 Cys Leu Leu His Ser Cys Ser Ser Gly Leu Thr Pro Pro Arg Pro Leu
          75                  80                  85

 cct tct cgg agt gac ccg ccc cca ggc cac ctg ctc cgg gga gtt ctg      580
 Pro Ser Arg Ser Asp Pro Pro Pro Gly His Leu Leu Arg Gly Val Leu
      90                  95                 100

 tgc act tta ctc ttt gga ctt ctc ctc acg tgt gcc ctg gtt tta tgg      628
 Cys Thr Leu Leu Phe Gly Leu Leu Leu Thr Cys Ala Leu Val Leu Trp
 105                 110                 115                 120

 gga gag gga atc gct gtt ggg aag gca gag cag ttg caa ccc tct ctg      676
 Gly Glu Gly Ile Ala Val Gly Lys Ala Glu Gln Leu Gln Pro Ser Leu
                 125                 130                 135

 ccc ttg ctt cat gtg gct gga gcc cag gca agg aga gca gga gcc agc      724
 Pro Leu Leu His Val Ala Gly Ala Gln Ala Arg Arg Ala Gly Ala Ser
             140                 145                 150

 gtg aga ctg agg ccc cct ggt gcc tat caa gga cca gag tga aggggac      773
 Val Arg Leu Arg Pro Pro Gly Ala Tyr Gln Gly Pro Glu 
         155                 160                 165

 tacatctccc agcccttcac cttttaaata tgagtggttt taaaaaaaaa aaaa          827




      <210> 399
      <211> 719
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(464)

      <400> 399
 ggattgggtt cacctcctga gctaagccca gg  atg ccg ccc aag cct cgg ggc      53
                                      Met Pro Pro Lys Pro Arg Gly
                                        1               5

 ctc cca agg tgt ccc cca tgc cag agt gtg tgg cct ctg cca ggc cca      101
 Leu Pro Arg Cys Pro Pro Cys Gln Ser Val Trp Pro Leu Pro Gly Pro
          10                  15                  20

 gga tgg ctc cag ggg gtt gga ctc cca ttt cct ctc ccc ttc cca ggt      149
 Gly Trp Leu Gln Gly Val Gly Leu Pro Phe Pro Leu Pro Phe Pro Gly
      25                  30                  35

 ctt tcc caa gcc cag agc ccc tgc ttt agt ttt cca gtg tgg gga gac      197
 Leu Ser Gln Ala Gln Ser Pro Cys Phe Ser Phe Pro Val Trp Gly Asp
  40                  45                  50                  55

 agg aga gtg gcc aca gag cct ggt tct gcg ctt ggt gct gct gga ctc      245
 Arg Arg Val Ala Thr Glu Pro Gly Ser Ala Leu Gly Ala Ala Gly Leu
                  60                  65                  70

 caa acc tgg ctc tgg agc tgc agt cct ggt gag ggc ggt ggc cct ggg      293
 Gln Thr Trp Leu Trp Ser Cys Ser Pro Gly Glu Gly Gly Gly Pro Gly
              75                  80                  85

 gaa gat gag ctc ccc aac act tgt tac ggc agt ttc cag tca caa gcc      341
 Glu Asp Glu Leu Pro Asn Thr Cys Tyr Gly Ser Phe Gln Ser Gln Ala
          90                  95                 100

 gca agg aca cag tct caa agg agc atc aga tgg ggt tgg ggg cat gtg      389
 Ala Arg Thr Gln Ser Gln Arg Ser Ile Arg Trp Gly Trp Gly His Val
     105                 110                 115

 ggg tgg ccc tgg ctc tcc cag gtg ggg tcc tgc cag gcc aag agc tat      437
 Gly Trp Pro Trp Leu Ser Gln Val Gly Ser Cys Gln Ala Lys Ser Tyr
 120                 125                 130                 135

 gct aag tgg ggc cca cca tgg cca tag gcccc tccgtgtcac ctggcataat      489
 Ala Lys Trp Gly Pro Pro Trp Pro 
                 140

 cagctggtag aaacagccct tggggactac atcacctgac ctgatctcca gagttccagg    549

 taccattttt tactgccccc caacagcact gtgcccctgt ccacaggtca tgtgactggg    609

 tgtcgggcac ggttcccttg cagcaatgaa cagtacatct gtggatgaag gtgggcaaat    669

 agaagtttgc cggtgggcgg gacggggcac ctgatcatgg gagccctgcg               719




      <210> 400
      <211> 1279
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (640)..(1113)

      <400> 400
 gaaggggggt ggagggggag ggggagtggt ggtgtgagta tagtgttggt ttgtgattag     60

 gagtaaggtg agggttgtgt ggacaggaga gatagaggtg ggggggatgt gggtgggtaa    120

 ggaaagtagg agtgatagaa ttgggggtag tagaggagtg ggagggtgtt ggagtgagag    180

 aaggaggatt aggttcgcat gggtgggtac tcggcggtgg tagagcttgc ttgttagtcc    240

 gggccggacg ctggtgtgtc caggacgggg ttcgccgcgt ttttttggtg aggtctccgc    300

 gctgggtgcg cccggggttc tctgggtcgc gtttggccgg ttgtgagttc gcttgtgggg    360

 gcgtgcgtcc tagagtgtgt gtttataggc gtgtgaggga taagagggaa atgtgtgttg    420

 gggaggagga ggatgtgggt cggagtgaaa aactttatta acaacaggtt tcaacgagaa    480

 agcaaatgaa tacccctaga aacatggaca gcatctcccc cagcagcagg caggggaagg    540

 gaggcaggag gggtaagcct agggtgttcc ctaggaaagg gccaggttcc ctctatccag    600

 ctgggggcac cgagacggcc tcattcaggg aagtccagg   atg gca gct gaa ggc     654
                                              Met Ala Ala Glu Gly
                                                1               5

 agc agg ttt agc agc caa agc cca ggc cta gtg gat aga cag ggt cca      702
 Ser Arg Phe Ser Ser Gln Ser Pro Gly Leu Val Asp Arg Gln Gly Pro
                  10                  15                  20

 aaa tgt gac cct tct agg ctg gta tca cca tgg ggg cgt cat ggg ctg      750
 Lys Cys Asp Pro Ser Arg Leu Val Ser Pro Trp Gly Arg His Gly Leu
              25                  30                  35

 agg att ctg cag ata gga cat cac cac ggc aga gat gga cag cat gaa      798
 Arg Ile Leu Gln Ile Gly His His His Gly Arg Asp Gly Gln His Glu
          40                  45                  50

 gct act cat cat ttg ctt cgt gtc ctc cga gct ccg aga gtt ggc aaa      846
 Ala Thr His His Leu Leu Arg Val Leu Arg Ala Pro Arg Val Gly Lys
      55                  60                  65

 gct gat gaa gga gca gta gac agc gac cca agc aca cca ctt cag ctt      894
 Ala Asp Glu Gly Ala Val Asp Ser Asp Pro Ser Thr Pro Leu Gln Leu
  70                  75                  80                  85

 aag cat gag gcc gca cat gct gaa gat cat gcc cag cag gtt cat gta      942
 Lys His Glu Ala Ala His Ala Glu Asp His Ala Gln Gln Val His Val
                  90                  95                 100

 gtc cgg cgt cgg gtc gtc caa ggc cgg gtt aca ttc gct cgg cgg ggg      990
 Val Arg Arg Arg Val Val Gln Gly Arg Val Thr Phe Ala Arg Arg Gly
             105                 110                 115

 ctt gta cct cag cac ttt gtt cgg cct ccg tgg gtc cga cat att gtt     1038
 Leu Val Pro Gln His Phe Val Arg Pro Pro Trp Val Arg His Ile Val
         120                 125                 130

 agt gga cat agc gag tcg aag gcc aga tca cgc ctc ttc cgc tgc agg     1086
 Ser Gly His Ser Glu Ser Lys Ala Arg Ser Arg Leu Phe Arg Cys Arg
     135                 140                 145

 aat cgc agc ttc cgg cgt gca agc tga gggcg gattttagag taacacccga     1138
 Asn Arg Ser Phe Arg Arg Ala Ser 
 150                 155

 ggccctcgca tttccgttcc tcatgacaga ggcttggact ccccttaccc agagaacgga   1198

 gatttaggag aagccagaag tcttcctttc aaagggaaaa tggggaaaag aacctgaaag   1258

 cgggcttcaa tagttccaac c                                             1279




      <210> 401
      <211> 717
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (193)..(666)

      <400> 401
 ccctgaagct tcatgaaaga agcagagaaa acaccaagca caagccaggc aggcaatgtg     60

 aagacacttt cacctgcata tcatttaaat ctcctacatc tggggttcta cagaggagct    120

 tgtccaatgc cacagaacta atgatcttgt aagggctgat tggtattgaa ccaatggctg    180

 tcgttgttcg ag    atg atg agt cca ggg ctc ctg ctg aag ccc tgg tgg     228
                  Met Met Ser Pro Gly Leu Leu Leu Lys Pro Trp Trp
                    1               5                  10

 gga ggg gca cag agc gag atg ggg cgt aat gga atg ctt gaa ggc tgc      276
 Gly Gly Ala Gln Ser Glu Met Gly Arg Asn Gly Met Leu Glu Gly Cys
          15                  20                  25

 tcc gtg atg tcg gtc gga gct tcc aga cta ggc gag ggc agg gtg agg      324
 Ser Val Met Ser Val Gly Ala Ser Arg Leu Gly Glu Gly Arg Val Arg
      30                  35                  40

 cct cgg gca cac agc cgg cgc cca gtc acc cgg ccc aga tgg agg gcg      372
 Pro Arg Ala His Ser Arg Arg Pro Val Thr Arg Pro Arg Trp Arg Ala
  45                  50                  55                  60

 gcc ggg ccc tgc aca ggc act tgc caa ggt ggc tca cac tca cgc aca      420
 Ala Gly Pro Cys Thr Gly Thr Cys Gln Gly Gly Ser His Ser Arg Thr
                  65                  70                  75

 ctc gta ctg aga ctc aag gcc gtc tcc aca act cca acc agt gca aat      468
 Leu Val Leu Arg Leu Lys Ala Val Ser Thr Thr Pro Thr Ser Ala Asn
              80                  85                  90

 gac tta gtg caa att aaa ttc aga agg gac ggg gga aac aga gtc gtg      516
 Asp Leu Val Gln Ile Lys Phe Arg Arg Asp Gly Gly Asn Arg Val Val
          95                 100                 105

 gag gct ttg aat ctc tca gaa aaa agg aaa gac agg aaa gct ctg tgt      564
 Glu Ala Leu Asn Leu Ser Glu Lys Arg Lys Asp Arg Lys Ala Leu Cys
     110                 115                 120

 ttt tct cag agt ctt cat cta caa ggg gaa gaa att gaa tta act gct      612
 Phe Ser Gln Ser Leu His Leu Gln Gly Glu Glu Ile Glu Leu Thr Ala
 125                 130                 135                 140

 ctc tct cgt tcc ttc cag ctc aga aat gtt tac ttt atg ata agc aat      660
 Leu Ser Arg Ser Phe Gln Leu Arg Asn Val Tyr Phe Met Ile Ser Asn
                 145                 150                 155

 att taa gatgaactaa attcaatgat agtgaatttt tgtcagttcc agatttctct       716
 Ile 


 t                                                                    717




      <210> 402
      <211> 540
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (176)..(436)

      <400> 402
 ccaaattttc tacgcgccaa ggttttgcaa ttactgtggc tcactgctct ggagaataat     60

 gcgacccgga cttaagtgaa aaatgtgaaa accggatggg cctattccat gcttggcaaa    120

 cgagagccct tgctgggggg caggcgcggt ggaacttgcc aagaccctgg caggg atg     178
                                                              Met
                                                                1

 ggt ctc caa ccc gga aat att tct cca acc tcg aaa ctc gtt tcc aga      226
 Gly Leu Gln Pro Gly Asn Ile Ser Pro Thr Ser Lys Leu Val Ser Arg
               5                  10                  15

 tcg acc cta aga cga cag gga aag gag agc agc ata gaa gga aat ggg      274
 Ser Thr Leu Arg Arg Gln Gly Lys Glu Ser Ser Ile Glu Gly Asn Gly
          20                  25                  30

 att ggg gtt aat tct tcc aac cga ctt ggt atc gac aac ttt gag ttc      322
 Ile Gly Val Asn Ser Ser Asn Arg Leu Gly Ile Asp Asn Phe Glu Phe
      35                  40                  45

 atc cga gtg ttg ggg aag ggg agt ctc ggc atg gat ttg att ccc aga      370
 Ile Arg Val Leu Gly Lys Gly Ser Leu Gly Met Asp Leu Ile Pro Arg
  50                  55                  60                  65

 cta agc cag gct ccc ctg ctg ctt act gac cca gtt ttc act gaa acc      418
 Leu Ser Gln Ala Pro Leu Leu Leu Thr Asp Pro Val Phe Thr Glu Thr
                  70                  75                  80

 att atc atg ttc gat tag tatgga ctacatacgc tctacctaat caccaccctg      472
 Ile Ile Met Phe Asp 
              85

 tcatctgttc cgagtaaacc ctttttcaag tatgcgtcct gcgctgttcc gaccccgcgt    532

 ctacaccg                                                             540




      <210> 403
      <211> 390
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (24)..(194)

      <400> 403
 attttagtca gggatcctac tga    atg ttt ttg tgc aag gaa gtg aaa tgg      50
                              Met Phe Leu Cys Lys Glu Val Lys Trp
                                1               5

 tca aat tta tgg gct gtg aag att aat ctg ctg act ata gca tat act       98
 Ser Asn Leu Trp Ala Val Lys Ile Asn Leu Leu Thr Ile Ala Tyr Thr
  10                  15                  20                  25

 atc aag cta gat tgg ggg atc tac tat tat ata agt atg aaa tat aag      146
 Ile Lys Leu Asp Trp Gly Ile Tyr Tyr Tyr Ile Ser Met Lys Tyr Lys
                  30                  35                  40

 ctg aac agg agc agg gtg aga aat agt gca aga aga aga aaa acc taa      194
 Leu Asn Arg Ser Arg Val Arg Asn Ser Ala Arg Arg Arg Lys Thr 
              45                  50                  55

 gatttctact tggataattg gtagaattat gatactatta aaaatcagaa gggagaacta    254

 ggagggaaaa aaatagaatt caagtttagg aaaaacagtt taaggtgatc acaaaagaca    314

 gttactaaat tcatacctca gctttctaac agcctcatca gagttgatac actgaaaagt    374

 ttgtaagtgg ttactt                                                    390




      <210> 404
      <211> 949
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (422)..(868)

      <220>
      <221> misc_feature
      <222> (1)...(949)
      <223> n = a,t,c or g

      <400> 404
 ggatgaggca cgcaataatt gattagtctc cttagcaccc cagtcttcac ttaggctccg     60

 agtcggatgt gtgagcattg taacgaagac atttccacca aggaacagct atgcatgata    120

 cgaatttata gactcagtat agggatttgg ccctgaaggc aaagatccac ccgagggtgc    180

 aaanacttct ctgcctgggg actggagggt gattcggctc ctgctggggc tcctccaatg    240

 gccccgaaga ggggctaaca cttagcctct cggtgcaagg gaagaaccga cccgtagtaa    300

 gaaggaaggc gcggtcctgg ggattagaag acgcagcggg actcggagcc aggcacccag    360

 gggtcggggc tagagctgga gtcgtgagcg cgcgcacgcc ccgctctggg aggaccgcga    420

 g    atg ccc gtg ctg aag cag ctg ggc ccc gcg cag ccc aag aag cgg     466
      Met Pro Val Leu Lys Gln Leu Gly Pro Ala Gln Pro Lys Lys Arg
        1               5                  10                  15

 cct gat cgc ggc gcc ctg tcc atc tcc gcg ccg ctc ggc gac ttc cgg      514
 Pro Asp Arg Gly Ala Leu Ser Ile Ser Ala Pro Leu Gly Asp Phe Arg
                  20                  25                  30

 cac acg ctg cac gtg ggg cgc ggc ggc gac gcc ttc ggg gac acc tcg      562
 His Thr Leu His Val Gly Arg Gly Gly Asp Ala Phe Gly Asp Thr Ser
              35                  40                  45

 ttc ctg agc cgc cac ggc ggc ggg ccg ccc ccc gag ccc cgg gcg ccc      610
 Phe Leu Ser Arg His Gly Gly Gly Pro Pro Pro Glu Pro Arg Ala Pro
          50                  55                  60

 ccc gcg ggg gcc ccg cgc tcc ccg ccg ccg ccc gcc gtc ccg cag tcc      658
 Pro Ala Gly Ala Pro Arg Ser Pro Pro Pro Pro Ala Val Pro Gln Ser
      65                  70                  75

 gca gcg ccc tcg cct gcc gac ccg ctg ctg tcc ttc cac ctg gat ctg      706
 Ala Ala Pro Ser Pro Ala Asp Pro Leu Leu Ser Phe His Leu Asp Leu
  80                  85                  90                  95

 ggg ccc tcc atg ctg gac gcg gtg ctg ggc gtc atg gac gcg gcg cgc      754
 Gly Pro Ser Met Leu Asp Ala Val Leu Gly Val Met Asp Ala Ala Arg
                 100                 105                 110

 ccg gag gcg gct gcc gcc aag ccc gac gcg gaa ccc cgc ccc ggg acg      802
 Pro Glu Ala Ala Ala Ala Lys Pro Asp Ala Glu Pro Arg Pro Gly Thr
             115                 120                 125

 cag ccc ccc cag gcc cgc tgc cgc ccc aac gcg gac ctc gag ctg aac      850
 Gln Pro Pro Gln Ala Arg Cys Arg Pro Asn Ala Asp Leu Glu Leu Asn
         130                 135                 140

 gac gtc atc ggc ctc tag gttccc tcattccccg cgcccttccc gcccggcacc      904
 Asp Val Ile Gly Leu 
     145

 ccacttctgt atacataaac ggccaaggtg tgtaaaaaaa aaaaa                    949




      <210> 405
      <211> 3061
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(2361)

      <400> 405
 agctccggta gaaaccatta tatccccttg gtaggcataa aaggggctgc tttgcccaaa     60

 ctgcct   atg aat ttg ctt cct aaa gca tgg ggt gtg cct cag gac ctt     108
          Met Asn Leu Leu Pro Lys Ala Trp Gly Val Pro Gln Asp Leu
            1               5                  10

 att aaa aag tac ata aaa ctt gaa gag gat ggt ggt tgt gtt att gga      156
 Ile Lys Lys Tyr Ile Lys Leu Glu Glu Asp Gly Gly Cys Val Ile Gly
  15                  20                  25                  30

 ggt gac aga agt ttg caa gat aaa tac tta ctt agg ctt gtt gct gct      204
 Gly Asp Arg Ser Leu Gln Asp Lys Tyr Leu Leu Arg Leu Val Ala Ala
                  35                  40                  45

 atg gaa gaa gtc ttt atg gac aaa cat ggt atc cat cct agt ttg gtt      252
 Met Glu Glu Val Phe Met Asp Lys His Gly Ile His Pro Ser Leu Val
              50                  55                  60

 gct gat gtc cat cag tat ttc tac aga agg act gga gtg ata gga gtt      300
 Ala Asp Val His Gln Tyr Phe Tyr Arg Arg Thr Gly Val Ile Gly Val
          65                  70                  75

 cag cct gag gaa gtc aca gca gct gct aaa aaa gca gta atg gat aat      348
 Gln Pro Glu Glu Val Thr Ala Ala Ala Lys Lys Ala Val Met Asp Asn
      80                  85                  90

 cgc ctt cac aaa tgt ttg ctc tgt ggt gcc ctt tct gaa ctt cat gtt      396
 Arg Leu His Lys Cys Leu Leu Cys Gly Ala Leu Ser Glu Leu His Val
  95                 100                 105                 110

 cct cca gag tgg ttg gct cct gga ggg aaa ttg tat aac ctg gca aaa      444
 Pro Pro Glu Trp Leu Ala Pro Gly Gly Lys Leu Tyr Asn Leu Ala Lys
                 115                 120                 125

 agt act cat gga cag ctg agg act gac aaa aat tac agc ttt ccc ttg      492
 Ser Thr His Gly Gln Leu Arg Thr Asp Lys Asn Tyr Ser Phe Pro Leu
             130                 135                 140

 aac aat ttg gtt tgc tca tat gat tca gtg aaa gat gtt ctg gta cca      540
 Asn Asn Leu Val Cys Ser Tyr Asp Ser Val Lys Asp Val Leu Val Pro
         145                 150                 155

 gac tat gga atg agt aac cta aca gct tgt aat tgg tgc cat ggc aca      588
 Asp Tyr Gly Met Ser Asn Leu Thr Ala Cys Asn Trp Cys His Gly Thr
     160                 165                 170

 tct gtg cga aag gtc aga gga gat ggg tct att gtg tat ttg gat gga      636
 Ser Val Arg Lys Val Arg Gly Asp Gly Ser Ile Val Tyr Leu Asp Gly
 175                 180                 185                 190

 gac aga act aat tct agg tcc act ggt ggc aaa tgt ggt tgt gga ttc      684
 Asp Arg Thr Asn Ser Arg Ser Thr Gly Gly Lys Cys Gly Cys Gly Phe
                 195                 200                 205

 aaa cac ttt tgg gat ggt aag gag tat gac aat cta cca gaa gct ttc      732
 Lys His Phe Trp Asp Gly Lys Glu Tyr Asp Asn Leu Pro Glu Ala Phe
             210                 215                 220

 cct att act tta gaa tgg ggt gga aga gtg gtc aga gaa aca gta tat      780
 Pro Ile Thr Leu Glu Trp Gly Gly Arg Val Val Arg Glu Thr Val Tyr
         225                 230                 235

 tgg ttc cag tat gaa agt gat tca tct ttg aat agt aat gtt tac gat      828
 Trp Phe Gln Tyr Glu Ser Asp Ser Ser Leu Asn Ser Asn Val Tyr Asp
     240                 245                 250

 gtt gca atg aaa ctt gtt acc aag cac ttt cca ggt gaa ttt ggg agt      876
 Val Ala Met Lys Leu Val Thr Lys His Phe Pro Gly Glu Phe Gly Ser
 255                 260                 265                 270

 gaa atc cta gtt cag aaa gtt gtc cac act ata ttg cat cag act gcc      924
 Glu Ile Leu Val Gln Lys Val Val His Thr Ile Leu His Gln Thr Ala
                 275                 280                 285

 aaa aag aat ccc gat gat tat act cct gta aat ata gat ggt gct cac      972
 Lys Lys Asn Pro Asp Asp Tyr Thr Pro Val Asn Ile Asp Gly Ala His
             290                 295                 300

 gcc caa aga gtt gga gat gtt caa gga caa gaa tca gag tct cag ctc     1020
 Ala Gln Arg Val Gly Asp Val Gln Gly Gln Glu Ser Glu Ser Gln Leu
         305                 310                 315

 cca act aaa att att ctt act gga cag aaa aca aaa act ttg cac aag     1068
 Pro Thr Lys Ile Ile Leu Thr Gly Gln Lys Thr Lys Thr Leu His Lys
     320                 325                 330

 gag gag tta aac atg agt aaa act gaa aga act att caa cag aat att     1116
 Glu Glu Leu Asn Met Ser Lys Thr Glu Arg Thr Ile Gln Gln Asn Ile
 335                 340                 345                 350

 acg gaa cag gct tct gta atg cag aaa cgg aaa aca gag aag tta aaa     1164
 Thr Glu Gln Ala Ser Val Met Gln Lys Arg Lys Thr Glu Lys Leu Lys
                 355                 360                 365

 caa gaa caa aaa ggg caa ccc agg act gtt tct ccc agt acc att cgt     1212
 Gln Glu Gln Lys Gly Gln Pro Arg Thr Val Ser Pro Ser Thr Ile Arg
             370                 375                 380

 gat ggt cca tcc tct gca cct gct aca cct acc aag gct ccc tat tca     1260
 Asp Gly Pro Ser Ser Ala Pro Ala Thr Pro Thr Lys Ala Pro Tyr Ser
         385                 390                 395

 ccg aca act tct aag gag aag aag atc cga atc aca act aat gat gga     1308
 Pro Thr Thr Ser Lys Glu Lys Lys Ile Arg Ile Thr Thr Asn Asp Gly
     400                 405                 410

 cga cag tcc atg gtt acc ctt aag tct tca aca acc ttt ttt gaa ctt     1356
 Arg Gln Ser Met Val Thr Leu Lys Ser Ser Thr Thr Phe Phe Glu Leu
 415                 420                 425                 430

 cag gaa agt ata gcc aga gaa ttc aac att cct cca tat tta cag tgt     1404
 Gln Glu Ser Ile Ala Arg Glu Phe Asn Ile Pro Pro Tyr Leu Gln Cys
                 435                 440                 445

 att cga tac ggg ttt cct cct aaa gag tta atg cca cca cag gca gga     1452
 Ile Arg Tyr Gly Phe Pro Pro Lys Glu Leu Met Pro Pro Gln Ala Gly
             450                 455                 460

 atg gaa aag gaa cca gtt cct tta cag cat ggc gac aga att aca ata     1500
 Met Glu Lys Glu Pro Val Pro Leu Gln His Gly Asp Arg Ile Thr Ile
         465                 470                 475

 gaa att cta aaa agt aaa gct gaa ggt ggt cag tct gct gca gca cac     1548
 Glu Ile Leu Lys Ser Lys Ala Glu Gly Gly Gln Ser Ala Ala Ala His
     480                 485                 490

 tca gcc cac act gtg aaa caa gaa gat att gct gtt act ggt aaa ctg     1596
 Ser Ala His Thr Val Lys Gln Glu Asp Ile Ala Val Thr Gly Lys Leu
 495                 500                 505                 510

 tca tct aag gaa ctt cag gag caa gct gaa aaa gaa atg tac tcc ttg     1644
 Ser Ser Lys Glu Leu Gln Glu Gln Ala Glu Lys Glu Met Tyr Ser Leu
                 515                 520                 525

 tgt ctt tta gca aca tta atg gga gaa gat gta tgg tct tat gca aag     1692
 Cys Leu Leu Ala Thr Leu Met Gly Glu Asp Val Trp Ser Tyr Ala Lys
             530                 535                 540

 gga ctt cct cac atg ttt cag cag ggt ggt gta ttc tac agt att atg     1740
 Gly Leu Pro His Met Phe Gln Gln Gly Gly Val Phe Tyr Ser Ile Met
         545                 550                 555

 aag aaa acc atg ggt atg gct gat ggc aag cat tgt act ttt cca cat     1788
 Lys Lys Thr Met Gly Met Ala Asp Gly Lys His Cys Thr Phe Pro His
     560                 565                 570

 ctg cct ggc aaa acc ttt gtc tat aat gct tct gaa gat aga ctg gaa     1836
 Leu Pro Gly Lys Thr Phe Val Tyr Asn Ala Ser Glu Asp Arg Leu Glu
 575                 580                 585                 590

 ttg tgt gtg gat gct gca gga cat ttc ccc att ggt cct gat gtt gaa     1884
 Leu Cys Val Asp Ala Ala Gly His Phe Pro Ile Gly Pro Asp Val Glu
                 595                 600                 605

 gat tta gtt aaa gag gct gta agt cag gtt cga gca gag gct act aca     1932
 Asp Leu Val Lys Glu Ala Val Ser Gln Val Arg Ala Glu Ala Thr Thr
             610                 615                 620

 aga agt agg gaa tca agt ccc tca cat ggg cta tta aaa cta ggt agt     1980
 Arg Ser Arg Glu Ser Ser Pro Ser His Gly Leu Leu Lys Leu Gly Ser
         625                 630                 635

 ggt gga gta gtg aaa aag aaa tct gag caa ctt cat aac gta act gcc     2028
 Gly Gly Val Val Lys Lys Lys Ser Glu Gln Leu His Asn Val Thr Ala
     640                 645                 650

 ttt cag gga aaa ggg cat tct tta gga act gca tct ggt aac cca cac     2076
 Phe Gln Gly Lys Gly His Ser Leu Gly Thr Ala Ser Gly Asn Pro His
 655                 660                 665                 670

 ctt gat cca aga gct agg gaa act tca gtt gta aga aag cat aat aca     2124
 Leu Asp Pro Arg Ala Arg Glu Thr Ser Val Val Arg Lys His Asn Thr
                 675                 680                 685

 ggg aca gac ttt agt aat agt tcc act aaa aca gag cct tct gta ttc     2172
 Gly Thr Asp Phe Ser Asn Ser Ser Thr Lys Thr Glu Pro Ser Val Phe
             690                 695                 700

 aca gct tct tct agt aat agt gag ctt att cga ata gct cct gga gta     2220
 Thr Ala Ser Ser Ser Asn Ser Glu Leu Ile Arg Ile Ala Pro Gly Val
         705                 710                 715

 gta aca atg aga gac ggc agg cag ctt gat cct gat ttg gtt gag gcc     2268
 Val Thr Met Arg Asp Gly Arg Gln Leu Asp Pro Asp Leu Val Glu Ala
     720                 725                 730

 cag cga aaa aaa att gca gga aat ggt ttc ttc tat tca ggc ttc aat     2316
 Gln Arg Lys Lys Ile Ala Gly Asn Gly Phe Phe Tyr Ser Gly Phe Asn
 735                 740                 745                 750

 gga cag gca cct tcg gga tca aag tac aga gca gtc acc atc tga tct     2364
 Gly Gln Ala Pro Ser Gly Ser Lys Tyr Arg Ala Val Thr Ile 
                 755                 760

 tcatcaaagg aaaacagaag ttgtgagttc ttctgcaaag tctgggagtc ttcagactgg   2424

 tttgcctgaa tcttttcctt taactggtgg tactgaaaat ttgaatacag aaacaactga   2484

 tggctgtgta gcagatgcac tgggagcagc ctttgccaca aggtcaaaag cacaaagggg   2544

 aaattccgtg gaggagcttg aagagatgga tagtcaagat gctgagatga ctaacacaac   2604

 tgagccaatg gatcactctt gatttaatta gaggctaata aaggcagaat gtttattgtg   2664

 aatatgtaat atttgttggc tgggccacgt aacttgatta gtcattaaaa atcttgtacg   2724

 tatataattc aaagattata tcttgttatt cagtgcatga tagcaagtgt gtgattggcc   2784

 atagctttta atatactgct gcccaggctg gctctgaatt tctataaatt agctgttaga   2844

 tctgctgaga tgactttctt ccatatatgt ggttcattgg aagttctttg taattttaat   2904

 tccatgaaag tcttaatgtt tccaacatga aaattctctt acttaaatac gtttgatttc   2964

 tgaaaagcct acaaatggag gggaaatgag attgtgctaa tggtgatgtc atcaaggtaa   3024

 ccatctcata tactagtgtc aaaagggtta tgtaaat                            3061




      <210> 406
      <211> 3466
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (165)..(788)

      <400> 406
 gctgtattca gagcatcgga ggcaaagcca gagtcttccg ggaagggatc acggtgattg     60

 atgtgaaagc ctccatcgac cccgtcccca ctagcatcga tgagtcctcc agcgtggtgc    120

 tccgctaccg gacaccccac ttccgggcct cggcccaggt ggtc atg ccg ccc atc     176
                                                  Met Pro Pro Ile
                                                    1

 ccc aag aag gag act tgg gta gtt ggc tgg atc cag gcg tgc agc cac      224
 Pro Lys Lys Glu Thr Trp Val Val Gly Trp Ile Gln Ala Cys Ser His
   5                  10                  15                  20

 atg gag ttc tac aac cag tac ggc gag cag ggc atg tcc agc tgg gag      272
 Met Glu Phe Tyr Asn Gln Tyr Gly Glu Gln Gly Met Ser Ser Trp Glu
                  25                  30                  35

 ctc ccc gac ctc cag gag ggc aag atc caa gcc atc agc gac tcg gac      320
 Leu Pro Asp Leu Gln Glu Gly Lys Ile Gln Ala Ile Ser Asp Ser Asp
              40                  45                  50

 ggg gtg aac tac ccc tgg tac ggc aac acc aca gag acc tgc acc atc      368
 Gly Val Asn Tyr Pro Trp Tyr Gly Asn Thr Thr Glu Thr Cys Thr Ile
          55                  60                  65

 gtg ggc ccc acc aag agg gac tcc aag ttc atc atc agc atg aat gac      416
 Val Gly Pro Thr Lys Arg Asp Ser Lys Phe Ile Ile Ser Met Asn Asp
      70                  75                  80

 aac ttt tac ccc agc gtc aca tgg gcc gtg ccc gtc agc gag agc aac      464
 Asn Phe Tyr Pro Ser Val Thr Trp Ala Val Pro Val Ser Glu Ser Asn
  85                  90                  95                 100

 gtg gcc aag ctc acc aac atc tac cgg gac cag agc ttc acc acc tgg      512
 Val Ala Lys Leu Thr Asn Ile Tyr Arg Asp Gln Ser Phe Thr Thr Trp
                 105                 110                 115

 ctg gtg gcc acc aac acc tcc acc aac gac atg atc atc ctg cag acg      560
 Leu Val Ala Thr Asn Thr Ser Thr Asn Asp Met Ile Ile Leu Gln Thr
             120                 125                 130

 ctg cac tgg cgc atg cag ctc agc atc gag gtg aac ccc aac cgg ccc      608
 Leu His Trp Arg Met Gln Leu Ser Ile Glu Val Asn Pro Asn Arg Pro
         135                 140                 145

 ctg ggc cag cgc gcc cgg ctg cgg gag ccc atc gcc cag gac cag ccc      656
 Leu Gly Gln Arg Ala Arg Leu Arg Glu Pro Ile Ala Gln Asp Gln Pro
     150                 155                 160

 aaa atc ctg agc aag aat gag ccc atc ccg ccc agc gcc ctg gtc aag      704
 Lys Ile Leu Ser Lys Asn Glu Pro Ile Pro Pro Ser Ala Leu Val Lys
 165                 170                 175                 180

 ccc aat gcc aac gat gcc cag gtc ctc atg tgg cgg ccc aag tat ggg      752
 Pro Asn Ala Asn Asp Ala Gln Val Leu Met Trp Arg Pro Lys Tyr Gly
                 185                 190                 195

 cag ccg ctg gtg gtg atc ccg ccc aag cac cgg tga cagc caggaccacc      802
 Gln Pro Leu Val Val Ile Pro Pro Lys His Arg 
             200                 205

 cgctaggtta gactcacaaa taataatacc gctgaaaaca aaactcagac tcactcttca    862

 gtcattcagc aagatacaac cattctaccc tctccagcgg gcggatctca ctgtgctgat    922

 gcccccggga aggcctcccc ggctctcggc acctgcttcc tttcagggag aggggagatc    982

 taagcaggac agacagaccc cacgtgcgcc ctcagggtga cctctggtct ccttgcctct   1042

 cctttttctc agtttcagtc gctcacttgt aacagattcc ctgaaacact gctttttccg   1102

 ttttttaaaa aaactcctct tttgggggct caggggcagg aggaggggga gctgattagg   1162

 agggaagctc cagcccccga tcaaagagac agatccacac tgctgccgat ttgtggcgct   1222

 ggccggcctt ccccccaggt ccctccgccc tctgtcatgc ggccttatgt agacttgctt   1282

 tgccaaactt ttgccttaag ctgaattgaa aggaagaaaa ccaatcggag aaagaaagca   1342

 ggatctcttt tctaccggac ttttcctctt ctgccagagg tggagggagg gttggggtcg   1402

 cccgcgagag tctcttgagc ccttcttccc ggttgtcttg ggagaagggg gaggatgggc   1462

 atttagaccc gaaaccagct gctcactctt tctttttggc agaaataaaa ccacaggtag   1522

 attctgcctg aacagcccct tctctccctc cacccccagg tcgtatccct gcacctgcgg   1582

 agaggggctg tgagctctgg cggggggtgg ctccaccagt cgcctggcct cttctcccct   1642

 ctcttcccag cagccttaac ttcccttggg cggctctagg aggagagagg caggctcctg   1702

 tgagcccagg gaattttcac cctctcagtc ctcaggaccc acccccagtt gagtccctgg   1762

 cccttcctcc aggtgtgtgg ctttttcctt ctccatccac actggtccca aatgcctggg   1822

 ggccggccac ctggaccgcc gacacacagc ctcaatgtta gtctcaaagg taaggaaggc   1882

 attcacgtcc cttcttgcag ggcattttaa gacttgaatc gggtgggccc cggcccctgt   1942

 ggctggctgg cccctggtgt actgtaaaag ggccaagaca gggctcgttc tcaggggcgc   2002

 ccctcccagg ccctcagggc agcgggacgg tgcagtcagg ctctgggtgc cacagtgatg   2062

 gaggtggaag gcacccaagc tctagggaag tcttgggagg cagtcggccg agcccctgct   2122

 tcctgtcctc aaataagtga atccaggcca agggctggga gggctgggtg ggcttatcgt   2182

 cgagagggtt cagagccact ctggaggctg ggctggcaca gtggagagcg acaggtgagg   2242

 acagacgtct ggaagcccat ccctgggacc tgccctccct tggtcccagg tcactggagc   2302

 tccagggctt acttagtcct gacccattgt gccagggttc tgagcagtgt cggccttgtg   2362

 gccacttgca ggggctatta ggggacatcc cgctgaagcc acgctccttc cagcttgcca   2422

 aacccacagc tacccgcccg ggacccacac tcagcctaat aattatcaag cacagaaaac   2482

 cgtccattta gaaaaataat ccatttctgc tgcagatgag ccacttgtaa gagtctccgt   2542

 gacagcgtgg gacggtgtgg gaaccaaagt ccctgccctg ctcctttgtc cacgggctat   2602

 tgcgtttatt caaggggtgc ttaatgaccg tttagccact gccgtcggtc tccgggccca   2662

 gctcgtgcca ggaggctgtc ctgggacaca ctgggctgga gctgccggct ggcacggtgc   2722

 tcagggggcc cctgatgggg gccaggacct ccccgcagaa actgcaggtt ctcttgtgag   2782

 gatggaggcc gtgccacccc gaaaggcagt agccttaggg gaacagtggg tcccagctgc   2842

 atgtctgagg atgggtgggg acagggctgg gactcagctt tcattcactg gagacttctc   2902

 cactcaggtc tttgttgcac taaagcaggg acaggaccct gggggttcag gaagcgggtc   2962

 tcaggccgct ggtttattcc tggaggtggg gctggagacc agaatggaaa ggggcttcct   3022

 gagctgctag ggggtgaagg acccccgaac ccgcatttct tgagtgagag caaacactcg   3082

 aggcaggagc cagcacccct cccactgcat gcccggcccc cagcccacct tgccccctga   3142

 cccaccttca cccgtgcccc ttctttctgc ccttcctcac cgaagaaggg ctaggaacac   3202

 cctggagagg ctgcaggtcc ggccacggac gctcagctga gccccggtct gctccttcag   3262

 cctccttgct cttgttggag cacaggcccc aggcttcctg ccagggcccc gattcttctt   3322

 atgtcctcca gccccgccct ggcgtggaca tccactcact ccttccagca ataagaaccg   3382

 tccttggtcg tggagagtac tgtgaaacaa accaatgcac ttaccaggag gcacaagact   3442

 cttgaagaag atgtaaaatg aacc                                          3466




      <210> 407
      <211> 1696
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (528)..(1652)

      <400> 407
 cttttttttt tttttttttg attttctaaa atactgcgtt attagttttc tttattgagt     60

 tttttggtgc ccctttaaat ttcgcaccta agatgagtgc ctcacttgcc tcactccagt    120

 cacagccgtg ctctccctga ctccaccaga gcaggcttag gtacttccca ggatcccagg    180

 gctccacggt ttgaaaacct ctccgtagct tcctgatgaa cacaccatgg ctccaagtgg    240

 ggtacagtgg ccccaggtca ggcaggtctg ttctggatca agagctggga cccctcacct    300

 gcacccaggc acagagctca gaccctgggc caaggctggg ctgcctgtga ccagcagccc    360

 cagaccacaa gcacttgtgt tgcaggggca gtgatcgctg ccgacatttt gtcatcaacc    420

 agcttcgaaa ccggcgttac atcatctcag gagacaccca gagccacagc accctggctg    480

 agcttgtgca ccattaccag gaggcacagc tcgagccctt caaagag  atg ctg act     536
                                                      Met Leu Thr
                                                        1

 gct gcc tgc ccc cgg ggg cac ttg gtg tgg ggt cat gat ccc tat tgg      584
 Ala Ala Cys Pro Arg Gly His Leu Val Trp Gly His Asp Pro Tyr Trp
       5                  10                  15

 aaa aag gga gac tgt ggc aat gtc tta cct gag gtc aga gac ctg gtg      632
 Lys Lys Gly Asp Cys Gly Asn Val Leu Pro Glu Val Arg Asp Leu Val
  20                  25                  30                  35

 gga atg ttg cag tct ctt acc agc agt ctc agg cag gca gct gga gac      680
 Gly Met Leu Gln Ser Leu Thr Ser Ser Leu Arg Gln Ala Ala Gly Asp
                  40                  45                  50

 tgg ctg ggc atg tgt gac cac ata cct gcc gta tcc gca tgc tcc cag      728
 Trp Leu Gly Met Cys Asp His Ile Pro Ala Val Ser Ala Cys Ser Gln
              55                  60                  65

 cca gag gac aat gat ctg tat gat gcc atc acc cgg ggc ctc cac cag      776
 Pro Glu Asp Asn Asp Leu Tyr Asp Ala Ile Thr Arg Gly Leu His Gln
          70                  75                  80

 acc atc gtg gac cca gaa aac cca cct gcc acg gca ttc ctc aca gtg      824
 Thr Ile Val Asp Pro Glu Asn Pro Pro Ala Thr Ala Phe Leu Thr Val
      85                  90                  95

 gtc ccc gac aag gcc gcc agc ccc cgc tct tct cca aag ccc cag gtc      872
 Val Pro Asp Lys Ala Ala Ser Pro Arg Ser Ser Pro Lys Pro Gln Val
 100                 105                 110                 115

 tcc ttc ctc cat gca cag aaa agc ctg gat gtg agt ccc cgg aac ctc      920
 Ser Phe Leu His Ala Gln Lys Ser Leu Asp Val Ser Pro Arg Asn Leu
                 120                 125                 130

 tcc cag gag gaa agc atg gag gct ccc atc aga gtg tct cca ctc cct      968
 Ser Gln Glu Glu Ser Met Glu Ala Pro Ile Arg Val Ser Pro Leu Pro
             135                 140                 145

 gag aag agt tcc tcc ctc ctg gaa gag tct ttt gga ggc ccc agt gac     1016
 Glu Lys Ser Ser Ser Leu Leu Glu Glu Ser Phe Gly Gly Pro Ser Asp
         150                 155                 160

 atc atc tat gca gac ctg agg agg atg aac cag gca cgg cta ggc ttg     1064
 Ile Ile Tyr Ala Asp Leu Arg Arg Met Asn Gln Ala Arg Leu Gly Leu
     165                 170                 175

 ggc aca gag ggg tcc ggc agg cat ggg cca gtt cca gct ggc agc cag     1112
 Gly Thr Glu Gly Ser Gly Arg His Gly Pro Val Pro Ala Gly Ser Gln
 180                 185                 190                 195

 gcc tac tcc cca ggc agg gag gcc caa agg aga ctc tca gat gga gaa     1160
 Ala Tyr Ser Pro Gly Arg Glu Ala Gln Arg Arg Leu Ser Asp Gly Glu
                 200                 205                 210

 cag aac agg cct gat ggc ctg ggg cct gtc ctt tct ggg gtg agc cca     1208
 Gln Asn Arg Pro Asp Gly Leu Gly Pro Val Leu Ser Gly Val Ser Pro
             215                 220                 225

 gac cag ggt ccc aca gag tct ccc act tcc tgg gga tgt tct gat gcc     1256
 Asp Gln Gly Pro Thr Glu Ser Pro Thr Ser Trp Gly Cys Ser Asp Ala
         230                 235                 240

 atg gga tcc ctg ggg gct acc tgg agg cag gag ttt cca aag ctg agc     1304
 Met Gly Ser Leu Gly Ala Thr Trp Arg Gln Glu Phe Pro Lys Leu Ser
     245                 250                 255

 caa gag gct cag ccc tgc tcc cag ggc agc tct gca gat atc tat gag     1352
 Gln Glu Ala Gln Pro Cys Ser Gln Gly Ser Ser Ala Asp Ile Tyr Glu
 260                 265                 270                 275

 ttc atc ggg aca gaa ggc ctc ctg caa gag gcc agg gac aca cca gac     1400
 Phe Ile Gly Thr Glu Gly Leu Leu Gln Glu Ala Arg Asp Thr Pro Asp
                 280                 285                 290

 caa gaa ggc agc acc tat gag cag atc cca gct tgc tgg ggt ggc cca     1448
 Gln Glu Gly Ser Thr Tyr Glu Gln Ile Pro Ala Cys Trp Gly Gly Pro
             295                 300                 305

 gcc agg gcc cca cat cct ggg gcc agt ccc aca tat agc cca tgg gtc     1496
 Ala Arg Ala Pro His Pro Gly Ala Ser Pro Thr Tyr Ser Pro Trp Val
         310                 315                 320

 cat ggc tac aag agg atc tca ggg acc cca gag ctc tca gag cct ggg     1544
 His Gly Tyr Lys Arg Ile Ser Gly Thr Pro Glu Leu Ser Glu Pro Gly
     325                 330                 335

 aac acc tat gaa cag atc cca gca acc aag agc aag gag act gga cgg     1592
 Asn Thr Tyr Glu Gln Ile Pro Ala Thr Lys Ser Lys Glu Thr Gly Arg
 340                 345                 350                 355

 aca cac aag cct gac aag ctt cgg agg ctc ttc ttc acg tac agg aag     1640
 Thr His Lys Pro Asp Lys Leu Arg Arg Leu Phe Phe Thr Tyr Arg Lys
                 360                 365                 370

 cac aaa ttc tga ggg cctggcatcc ggcagcccac cagtgggttt cctggtaccc     1695
 His Lys Phe 


 a                                                                   1696




      <210> 408
      <211> 943
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (116)..(502)

      <400> 408
 tttcgtcgta cggggcctgc gggtgtcggt gaaggcggag gccccggcgg ggccggccct     60

 ggggctcccg tcccctgagg cggagtccgg tgttgaccgt ggcgagccgg agccc atg     118
                                                              Met
                                                                1

 gag gtg gag gag ggc gag ctg gaa atc gtg cct gtg cgg cgc tcg ctc      166
 Glu Val Glu Glu Gly Glu Leu Glu Ile Val Pro Val Arg Arg Ser Leu
               5                  10                  15

 aag gaa ctg atc ccg gac acg agc aga aga tat gaa aac aag gct ggc      214
 Lys Glu Leu Ile Pro Asp Thr Ser Arg Arg Tyr Glu Asn Lys Ala Gly
          20                  25                  30

 agc ttc atc act gga att gat gtc acc tcc aag gaa gca att gaa aag      262
 Ser Phe Ile Thr Gly Ile Asp Val Thr Ser Lys Glu Ala Ile Glu Lys
      35                  40                  45

 aaa gag cag cga gcc aag cgc ttc cat ttt cga tcg gaa gta aat ctt      310
 Lys Glu Gln Arg Ala Lys Arg Phe His Phe Arg Ser Glu Val Asn Leu
  50                  55                  60                  65

 gcc caa aga aat gta gcc ttg gac cga gac atg atg aag aaa gca atc      358
 Ala Gln Arg Asn Val Ala Leu Asp Arg Asp Met Met Lys Lys Ala Ile
                  70                  75                  80

 ccc aag gtg aga ctg gag aca atc tat att tgc gga gta gat gag atg      406
 Pro Lys Val Arg Leu Glu Thr Ile Tyr Ile Cys Gly Val Asp Glu Met
              85                  90                  95

 agc acc caa gat gtc ttt tcc tat ttt aaa gaa tat cct cca gct cac      454
 Ser Thr Gln Asp Val Phe Ser Tyr Phe Lys Glu Tyr Pro Pro Ala His
         100                 105                 110

 atc gaa tgt ttg gat gat acc tcc tgt aag tac acc cga ttt cct tga      502
 Ile Glu Cys Leu Asp Asp Thr Ser Cys Lys Tyr Thr Arg Phe Pro 
     115                 120                 125

 atatgctttt gtgatgattt ttcaagattt cttgccatca gagatggtga atggttctgg    562

 cccatactac ttgtttatgc cgaacttctg ctgttagtcc aggagagaaa aaattgtcga    622

 gcagtgaaac gcagcatgcc cttgccagtc tgccagctca taccccatag tgtcccacgt    682

 cagctgagag gtggtggcca gggctctagg aggtgggtta ctggcctctg aatctgccgt    742

 agttgattga ggcctctgtt aacactcacc ttttcccaca aaggagagga tccaactgcg    802

 tagacttggg gctgcatttt cagagccttg gactttgtca ttactgcctt ctgtactgtt    862

 actcagaggg ctgactctgc ctgtgtctct gacctagaga tagaccagaa tagacactgg    922

 acagagtgtc attctgaata g                                              943




      <210> 409
      <211> 1022
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (270)..(542)

      <220>
      <221> misc_feature
      <222> (1)...(1022)
      <223> n = a,t,c or g

      <400> 409
 aattcccggg tngaccacgc gtccgcacac catcacacct ttccagttcc tgtaaccaaa     60

 acatttctgt cctgattctc agtcagcttc ccaactggga catgttttat ttcattggaa    120

 ctgagtactg tcctgatgct gaatgtaaca ggggtaacag aaaagcagca agatcaggaa    180

 gtagagaata taatgaaacc agtcaagttt tggaaatcag ggacattaga tcactgtgga    240

 cctaaaacaa acaaacaact ataaggaaa  atg gca tta gaa atg gtc tgg gga     293
                                  Met Ala Leu Glu Met Val Trp Gly
                                    1               5

 tca gtt tat cac tgc agt tgt tac atc acc cca tgg tct aaa ata cag      341
 Ser Val Tyr His Cys Ser Cys Tyr Ile Thr Pro Trp Ser Lys Ile Gln
      10                  15                  20

 agc ttt agt ctg tct ctg ttt cag ttc att tta cag gag gtg aac atc      389
 Ser Phe Ser Leu Ser Leu Phe Gln Phe Ile Leu Gln Glu Val Asn Ile
  25                  30                  35                  40

 aca ctt cca gaa aac tct gtc tgg tat gaa aga tat aaa ttt gat att      437
 Thr Leu Pro Glu Asn Ser Val Trp Tyr Glu Arg Tyr Lys Phe Asp Ile
                  45                  50                  55

 cct gtc ttt cac ttg aat ggc cag ttt ctg atg atg cat cga gta aac      485
 Pro Val Phe His Leu Asn Gly Gln Phe Leu Met Met His Arg Val Asn
              60                  65                  70

 acc tca aaa ctt gaa aaa cag ctc ctg aaa ctt gag cag caa agt act      533
 Thr Ser Lys Leu Glu Lys Gln Leu Leu Lys Leu Glu Gln Gln Ser Thr
          75                  80                  85

 gga ggc tga ctgatgc cctcatgatt ttccaccctc tcttcccata aagcatcttc      589
 Gly Gly 
      90

 ctaaggaaat gaccatggcc tgatactcat tttgttactt gtacagagcc ctaaggatgt    649

 tctgaattca gtggtgccaa ataaatgttg acattcccct tttggttgat ggaagtatca    709

 gtgtgggaac tgtttgctta atggcatttt ataaaataag aagagcatat tagcagggag    769

 ggagatgatg gagggaggga gaagtccatt tgtcttattt atcctttttg tattaataga    829

 gaagcacttc acagtcactg ggcaatgcca tttataggaa gaaggttctg cattcctgct    889

 gctgccccgg agggcttaac tttttaatga aagaataaat gctcttccac tcagtagata    949

 aagtgaaatg tgaattgtta ataactgtgc acggtcaata aagcgatgtt ttaaggaata   1009

 aaaaaaaaaa aaa                                                      1022




      <210> 410
      <211> 549
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (284)..(472)

      <400> 410
 atagttggta tttaaaaatt ctaaaatatt taataattaa tattgatggg aagactgata     60

 tacaatgcaa ttatttattt tacaaggaga ttctatacat cagggaggca tcttgaagta    120

 caatacacca ggctttcatt tcttctttac attatgattg tgagtttcca tataagttgg    180

 tacttacatg gaaagggaac acaaaatcca tttttatata cataaaaaca aaacacccaa    240

 agagacttga cccccaaaat gtcttgtttc acttgaaaat aac  atg aat gag acg     295
                                                  Met Asn Glu Thr
                                                    1

 aaa gat gaa cca gat tac ttg gtg acg cac aga agg cga aca agt agc      343
 Lys Asp Glu Pro Asp Tyr Leu Val Thr His Arg Arg Arg Thr Ser Ser
   5                  10                  15                  20

 tca gga aat caa atc ctg ttt caa gct tgg cac att aag ggt aag aaa      391
 Ser Gly Asn Gln Ile Leu Phe Gln Ala Trp His Ile Lys Gly Lys Lys
                  25                  30                  35

 ggt agt gaa aga agg gtt cga aaa tat cat ctc aag cca caa aaa atc      439
 Gly Ser Glu Arg Arg Val Arg Lys Tyr His Leu Lys Pro Gln Lys Ile
              40                  45                  50

 tgg cag aag aca gcc tcc caa tca ata aga tag aatggtta gaagtcaagt      490
 Trp Gln Lys Thr Ala Ser Gln Ser Ile Arg 
          55                  60

 tagagttatt gtgttggcta cattatatcc agacctctat atactgagtg ggaatgttc     549




      <210> 411
      <211> 603
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (93)..(425)

      <400> 411
 gcgcacgccg ccttcgccgc tgactccgtc tgttgggggg cgaacacgcc gcggtcctcg     60

 tcgtgtgaag taagaactct gctagagagg aa  atg gct gct tca tca tca tcc     113
                                      Met Ala Ala Ser Ser Ser Ser
                                        1               5

 tcc tca gct ggt ggg gtc agt gga agt tct gtc act gga tct ggt ttc      161
 Ser Ser Ala Gly Gly Val Ser Gly Ser Ser Val Thr Gly Ser Gly Phe
          10                  15                  20

 agt gtc tca gac ctt gcc cca cca cgg aaa gcc ctt ttc acc tac ccc      209
 Ser Val Ser Asp Leu Ala Pro Pro Arg Lys Ala Leu Phe Thr Tyr Pro
      25                  30                  35

 aaa gga gct gga gag atg tta gaa gat ggc tct gag aga ttc ctc tgc      257
 Lys Gly Ala Gly Glu Met Leu Glu Asp Gly Ser Glu Arg Phe Leu Cys
  40                  45                  50                  55

 gaa tct gtt ttt agc tat caa gtg gca tcc acg ctt aaa cag gtg aaa      305
 Glu Ser Val Phe Ser Tyr Gln Val Ala Ser Thr Leu Lys Gln Val Lys
                  60                  65                  70

 cat gat cag caa gtt gct cgg atg gaa aaa cta gct ggt ttg gta gaa      353
 His Asp Gln Gln Val Ala Arg Met Glu Lys Leu Ala Gly Leu Val Glu
              75                  80                  85

 gag ctg gag gct gac gag tgg cgg ttt aag ccc atc gag cag ctg ctg      401
 Glu Leu Glu Ala Asp Glu Trp Arg Phe Lys Pro Ile Glu Gln Leu Leu
          90                  95                 100

 gga ttc acc ccc tct tca ggt tga tactgcctgg atggtcacct ctggtgcgca     455
 Gly Phe Thr Pro Ser Ser Gly 
     105                 110

 gcaagtgcaa agccagtggg ggactttctc acagcttaca tagccatcca gagatccaca    515

 gctacgtcac tgaattgtta atgcacattt gtacttggct tctctgtatc tattcacagg    575

 caacaaatac ttatatgtgc gatcttcg                                       603




      <210> 412
      <211> 857
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(726)

      <400> 412
 gggcccctcg tttattctct agagcggccg ctcggcccag gcccgccttc cgcagggtgt     60

 cgccgctgtg ccgctagcgg tgccccgcct gctgcggtgg caccagccag gaggcggagt    120

 ggaagtggcc gtggggcggg t  atg gga cta gct ggc gtg tgc gcc ctg aga     171
                          Met Gly Leu Ala Gly Val Cys Ala Leu Arg
                            1               5                  10

 cgc tca gcg ggc tat ata ctc gtc ggt ggg gcc ggc ggt cag tct gcg      219
 Arg Ser Ala Gly Tyr Ile Leu Val Gly Gly Ala Gly Gly Gln Ser Ala
                  15                  20                  25

 gca gcg gca gca aga cgg tgc agt gaa gga gag tgg gcg tct ggc ggg      267
 Ala Ala Ala Ala Arg Arg Cys Ser Glu Gly Glu Trp Ala Ser Gly Gly
              30                  35                  40

 gtc cgc agt ttc agc aga gcc gct gca gcc atg gcc cca atc aag gtg      315
 Val Arg Ser Phe Ser Arg Ala Ala Ala Ala Met Ala Pro Ile Lys Val
          45                  50                  55

 gga gat gcc atc cca gca gtg gag gtg ttt gaa ggg gag cca ggg aac      363
 Gly Asp Ala Ile Pro Ala Val Glu Val Phe Glu Gly Glu Pro Gly Asn
      60                  65                  70

 aag gtg aac ctg gca gag ctg ttc aag ggc aag aag ggt gtg ctg ttt      411
 Lys Val Asn Leu Ala Glu Leu Phe Lys Gly Lys Lys Gly Val Leu Phe
  75                  80                  85                  90

 gga gtt cct ggg gcc ttc acc cct gga tgt tcc aag aca cac ctg cca      459
 Gly Val Pro Gly Ala Phe Thr Pro Gly Cys Ser Lys Thr His Leu Pro
                  95                 100                 105

 ggg ttt gtg gag cag gct gag gct ctg aag gcc aag gga gtc cag gtg      507
 Gly Phe Val Glu Gln Ala Glu Ala Leu Lys Ala Lys Gly Val Gln Val
             110                 115                 120

 gtg gcc tgt ctg agt gtt aat gat gcc ttt gtg act ggg gcc ttt ggg      555
 Val Ala Cys Leu Ser Val Asn Asp Ala Phe Val Thr Gly Ala Phe Gly
         125                 130                 135

 aag gag aca gac tta tta cta gat gat tcg ctg gtg tcc atc ttt ggg      603
 Lys Glu Thr Asp Leu Leu Leu Asp Asp Ser Leu Val Ser Ile Phe Gly
     140                 145                 150

 aat cga cgt ctc aag agg ttc tcc atg gtg gta cag gat ggc ata gtg      651
 Asn Arg Arg Leu Lys Arg Phe Ser Met Val Val Gln Asp Gly Ile Val
 155                 160                 165                 170

 aag gcc ctg aat gtg gaa cca gat ggc aca ggc ctc acc tgc agc ctg      699
 Lys Ala Leu Asn Val Glu Pro Asp Gly Thr Gly Leu Thr Cys Ser Leu
                 175                 180                 185

 gca ccc aat atc atc tca cag ctc tga ggccc tgggccagat tacttcctcc      751
 Ala Pro Asn Ile Ile Ser Gln Leu 
             190

 acccctccct atctcacctg cccagccctg tgctggggcc ctgcaattgg aatgttggcc    811

 agatttctgc aataaacact tgtggtttgc ggccaaaaaa aaaaaa                   857




      <210> 413
      <211> 766
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(393)

      <400> 413
 gggcccctcg tttattctct agagcggccg ctcggcccag gcccgccttc cgcagggtgt     60

 cgccgctgtg ccgctagcgg tgccccgcct gctgcggtgg caccagccag gaggcggagt    120

 ggaagtggcc gtggggcggg t  atg gga cta gct ggc gtg tgc gcc ctg aga     171
                          Met Gly Leu Ala Gly Val Cys Ala Leu Arg
                            1               5                  10

 cgc tca gcg ggc tat ata ctc gtc ggt ggg gcc ggc ggt cag tct gcg      219
 Arg Ser Ala Gly Tyr Ile Leu Val Gly Gly Ala Gly Gly Gln Ser Ala
                  15                  20                  25

 gca gcg gca gca aga cgg tgc agt gaa gaa gag tgg gcg tct ggc ggg      267
 Ala Ala Ala Ala Arg Arg Cys Ser Glu Glu Glu Trp Ala Ser Gly Gly
              30                  35                  40

 gtc cac agt ttc agc aga gcc gct gca gcc atg gcc cca atc aag aca      315
 Val His Ser Phe Ser Arg Ala Ala Ala Ala Met Ala Pro Ile Lys Thr
          45                  50                  55

 cac ctg cca ggg ttt gtg gag cag gct gag gct ctg aag gcc aag ggc      363
 His Leu Pro Gly Phe Val Glu Gln Ala Glu Ala Leu Lys Ala Lys Gly
      60                  65                  70

 agt cca ggt ggt ggc ctg tct gag tgt taa t gatgcctttg tgactggcga      414
 Ser Pro Gly Gly Gly Leu Ser Glu Cys 
  75                  80

 gtggggccga gcccacaagg cggaaggcaa ggttcggctc ctggctgatc ccactggggc    474

 ctttgggaag gagacagact tattactaga tgattcgctg gtgtccatct ttgggaatcg    534

 acgtctcaag aggttctcca tggtggtaca ggatggcata gtgaaggccc tgaatgtgga    594

 accagatggc acaggcctca cctgcagcct ggcacccaat atcatctcac agctctgagg    654

 ccctgggcca gattacttcc tccacccctc cctatctcac ctgcccagcc ctgtgctggg    714

 gccctgcaat tggaatgttg gccagatttc tgcaataaac acttgtggtt tg            766




      <210> 414
      <211> 726
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (82)..(594)

      <400> 414
 cgccgctgtg ccgctagcgg tgccccgcct gctgcggtgg caccagccag gaggcggagt     60

 ggaagtggcc gtggggcggg t  atg gga cta gct ggc gtg tgc gcc ctg aga     111
                          Met Gly Leu Ala Gly Val Cys Ala Leu Arg
                            1               5                  10

 cgc tca gcg ggc tat ata ctc gtc ggt ggg gcc ggc ggt cag tct gcg      159
 Arg Ser Ala Gly Tyr Ile Leu Val Gly Gly Ala Gly Gly Gln Ser Ala
                  15                  20                  25

 gca gcg gca gca aga cgg tgc agt gaa gga gag tgg gcg tct ggc ggg      207
 Ala Ala Ala Ala Arg Arg Cys Ser Glu Gly Glu Trp Ala Ser Gly Gly
              30                  35                  40

 gtc cgc agt ttc agc aga gcc gct gca gcc atg gcc cca atc aag gtg      255
 Val Arg Ser Phe Ser Arg Ala Ala Ala Ala Met Ala Pro Ile Lys Val
          45                  50                  55

 gga gat gcc atc cca gca gtg gag gtg ttt gaa ggg gag cca ggg aac      303
 Gly Asp Ala Ile Pro Ala Val Glu Val Phe Glu Gly Glu Pro Gly Asn
      60                  65                  70

 aag gtg aac ctg gca gag ctg ttc aag ggc aag aag ggt gtg ctg ttt      351
 Lys Val Asn Leu Ala Glu Leu Phe Lys Gly Lys Lys Gly Val Leu Phe
  75                  80                  85                  90

 gga gtt cct ggg gcc ttc acc cct gga tgt tcc aag gtt cgg ctc ctg      399
 Gly Val Pro Gly Ala Phe Thr Pro Gly Cys Ser Lys Val Arg Leu Leu
                  95                 100                 105

 gct gat ccc act ggg gcc ttt ggg aag gag aca gac tta tta cta gat      447
 Ala Asp Pro Thr Gly Ala Phe Gly Lys Glu Thr Asp Leu Leu Leu Asp
             110                 115                 120

 gat tcg ctg gtg tcc atc ttt ggg aat cga cgt ctc aag agg ttc tcc      495
 Asp Ser Leu Val Ser Ile Phe Gly Asn Arg Arg Leu Lys Arg Phe Ser
         125                 130                 135

 atg gtg gta cag gat ggc ata gtg aag gcc ctg aat gtg gaa cca gat      543
 Met Val Val Gln Asp Gly Ile Val Lys Ala Leu Asn Val Glu Pro Asp
     140                 145                 150

 ggc aca ggc ctc acc tgc agc ctg gca ccc aat atc atc tca cag ctc      591
 Gly Thr Gly Leu Thr Cys Ser Leu Ala Pro Asn Ile Ile Ser Gln Leu
 155                 160                 165                 170

 tga ggcc ctgggccaga ttacttcctc cacccctccc tatctcacct gcccagccgt      648
 


 gtgctggggc cctgcaattg gaatgttggc cagatttctg caataaacac ttgtggtttg    708

 cggccaaaaa aaaaaaaa                                                  726




      <210> 415
      <211> 1529
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (307)..(1179)

      <400> 415
 ttagttccac agccccagat tcaaggcctg agctttcctc ttttcatgaa ggtacttcag     60

 caaaacttcc cggttgccgt cgtagaaggc gggataagca tagcccgtgt gaatctgtga    120

 cctgcccggc actcgcagtt ggcagtcgta gaagcggttg gccgtcgtag aagcgtggat    180

 aagcatagcc cgtgtgaatc tgtgaacctg cctgcgctcg cggttggccg tcgtagaagc    240

 ctggataagc atagcccgtg tgaatctgtg aacctgcctg tgctcacggt tggccgtcgt    300

 agaagc   atg gat aag cat agc ccg tgt gaa tct gtg aac ctg ccc gcg     348
          Met Asp Lys His Ser Pro Cys Glu Ser Val Asn Leu Pro Ala
            1               5                  10

 ctc gcg gtt ggc cgt cgt aga agg ccc cat aag cat agc ccg tgt gaa      396
 Leu Ala Val Gly Arg Arg Arg Arg Pro His Lys His Ser Pro Cys Glu
  15                  20                  25                  30

 tct gtg aac ctg cct gtg ctc acg gtt ggc cgt cgt aga agc ctg gat      444
 Ser Val Asn Leu Pro Val Leu Thr Val Gly Arg Arg Arg Ser Leu Asp
                  35                  40                  45

 aag cat agc ccg tgt gaa tct gtg aac ctg ccc gca ctc gcg gtt ggc      492
 Lys His Ser Pro Cys Glu Ser Val Asn Leu Pro Ala Leu Ala Val Gly
              50                  55                  60

 cat cgt aga agc ctg gat aag cat agc ccg tgt gaa tct gtg aac ctg      540
 His Arg Arg Ser Leu Asp Lys His Ser Pro Cys Glu Ser Val Asn Leu
          65                  70                  75

 ccc gca ctc gcg gtt ggc cat cgt aga agt gtg gat aag cat agc cca      588
 Pro Ala Leu Ala Val Gly His Arg Arg Ser Val Asp Lys His Ser Pro
      80                  85                  90

 tgt gaa tct gtg aac ctg ccc gca ttc gcg gtt ggc cgt cgt aga agg      636
 Cys Glu Ser Val Asn Leu Pro Ala Phe Ala Val Gly Arg Arg Arg Arg
  95                 100                 105                 110

 ccc cat aag cat agc ccg tgt gaa tct gtg aac ctg ccc gca ctc gcg      684
 Pro His Lys His Ser Pro Cys Glu Ser Val Asn Leu Pro Ala Leu Ala
                 115                 120                 125

 gtt ggc cgt tgt aga agc ctg gat aag cat agc ccg tgt gaa tct gtg      732
 Val Gly Arg Cys Arg Ser Leu Asp Lys His Ser Pro Cys Glu Ser Val
             130                 135                 140

 aac ctg ccc gca ctc gcg gtt ggc cgt cgt aga agc ctg gat aag cat      780
 Asn Leu Pro Ala Leu Ala Val Gly Arg Arg Arg Ser Leu Asp Lys His
         145                 150                 155

 agc ccg tgt gaa tct gtg aac ctg ccc gca ctc gcg gtt ggc cat cgt      828
 Ser Pro Cys Glu Ser Val Asn Leu Pro Ala Leu Ala Val Gly His Arg
     160                 165                 170

 aga agt gtg gat aag cat agc cca tgt gaa tct gtg aac ctg ccc gca      876
 Arg Ser Val Asp Lys His Ser Pro Cys Glu Ser Val Asn Leu Pro Ala
 175                 180                 185                 190

 ttc gcg gtt ggc cgt cgt aga agg ccc cat aag cat agc ccg tgt gaa      924
 Phe Ala Val Gly Arg Arg Arg Arg Pro His Lys His Ser Pro Cys Glu
                 195                 200                 205

 tct gtg aac ctg ccc gca ctc gca gct ggc cgt cgt aga agg ccc cac      972
 Ser Val Asn Leu Pro Ala Leu Ala Ala Gly Arg Arg Arg Arg Pro His
             210                 215                 220

 aag cat agc ccg tgt gaa tct gtg aac ctg ccc gca ctc gcg gct ggc     1020
 Lys His Ser Pro Cys Glu Ser Val Asn Leu Pro Ala Leu Ala Ala Gly
         225                 230                 235

 cgt cgt aga agg ccc cat aag cat agc ccg ggt gaa tct gtg aac ctg     1068
 Arg Arg Arg Arg Pro His Lys His Ser Pro Gly Glu Ser Val Asn Leu
     240                 245                 250

 ccc gca ctc gcg gtt ggc cgt cgt aga agc gtg gat aag cat agc ccg     1116
 Pro Ala Leu Ala Val Gly Arg Arg Arg Ser Val Asp Lys His Ser Pro
 255                 260                 265                 270

 tgt gaa tct gtg aac ctg ccc gca ctc gca gtt ggc cgt cgt aga agc     1164
 Cys Glu Ser Val Asn Leu Pro Ala Leu Ala Val Gly Arg Arg Arg Ser
                 275                 280                 285

 ggt tgg ccg tcg tag aagcgtggat aagcatagcc cgtgtgaatc tgtgaacctg     1219
 Gly Trp Pro Ser 
             290

 cctgcgctcg cggttggccg tcttagaagc gtggataagc atagcccgtg tgatttttcg   1279

 ctgagccctg gcttgggcag ctcttgcaag ttctgccttg tgcttttggg caaaggcttg   1339

 gggtccctgt gctactgttg agattcggtt aatggtggga atgtggcccc gtcctcactg   1399

 ccaccttcca ggccctccta caccgactca ccaccagcct gatgttcaca gagagtagtt   1459

 tctctgcccc aaataggaaa gaatctgcta tgtcttccta attcaccacc aggggtattg   1519

 aagtgctggg                                                          1529




      <210> 416
      <211> 3471
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(3424)

      <400> 416
 tcagacattg ctgtctggtg ctcctctctc agtggccatc  atg tct ttg aca tct      55
                                              Met Ser Leu Thr Ser
                                                1               5

 gct tac cag cat aaa tta gca gag aag ctc act atc ctg aat gat cgc      103
 Ala Tyr Gln His Lys Leu Ala Glu Lys Leu Thr Ile Leu Asn Asp Arg
                  10                  15                  20

 ggt cag ggg gtt ctc atc cgt atg tat aac atc aag aag act tgt tca      151
 Gly Gln Gly Val Leu Ile Arg Met Tyr Asn Ile Lys Lys Thr Cys Ser
              25                  30                  35

 gac ccc aaa tct aag cca cct ttc tta ctg gaa aag tcc atg gaa cca      199
 Asp Pro Lys Ser Lys Pro Pro Phe Leu Leu Glu Lys Ser Met Glu Pro
          40                  45                  50

 tct ctc aag tat atc aac aag aaa ttt ccc aac ata gat gtc cga aac      247
 Ser Leu Lys Tyr Ile Asn Lys Lys Phe Pro Asn Ile Asp Val Arg Asn
      55                  60                  65

 agc acg caa cat tta gga cca gta cat cgt gaa aaa gcc gag ata att      295
 Ser Thr Gln His Leu Gly Pro Val His Arg Glu Lys Ala Glu Ile Ile
  70                  75                  80                  85

 aga ttc ctc acc aac tac tac cag tca ttt gtg gat gtc atg gaa ttt      343
 Arg Phe Leu Thr Asn Tyr Tyr Gln Ser Phe Val Asp Val Met Glu Phe
                  90                  95                 100

 cgg gat cat gta tat gaa ctt ctc aac acc att gat gcc tgc cag tgc      391
 Arg Asp His Val Tyr Glu Leu Leu Asn Thr Ile Asp Ala Cys Gln Cys
             105                 110                 115

 cat ttt gat atc aat ctc aac ttt gat ttc act cgg agt tac ctg gac      439
 His Phe Asp Ile Asn Leu Asn Phe Asp Phe Thr Arg Ser Tyr Leu Asp
         120                 125                 130

 ttg att gta act tac acc tca gtc att tta ctt ctg tca cgg att gaa      487
 Leu Ile Val Thr Tyr Thr Ser Val Ile Leu Leu Leu Ser Arg Ile Glu
     135                 140                 145

 gat cgg cgg ata ctc att ggc atg tac aat tgt gcc cat gag atg ctg      535
 Asp Arg Arg Ile Leu Ile Gly Met Tyr Asn Cys Ala His Glu Met Leu
 150                 155                 160                 165

 cat ggg cat ggt gac ccc agt ttt gcc cgt ctg ggt cag atg gtc ttg      583
 His Gly His Gly Asp Pro Ser Phe Ala Arg Leu Gly Gln Met Val Leu
                 170                 175                 180

 gag tat gac cac cct ctg aag aag ctg aca gaa gag ttt ggg cct cac      631
 Glu Tyr Asp His Pro Leu Lys Lys Leu Thr Glu Glu Phe Gly Pro His
             185                 190                 195

 aca aag gct gtg agt gga gcc ctc ctc tct ttg cat ttc ctc ttt gtc      679
 Thr Lys Ala Val Ser Gly Ala Leu Leu Ser Leu His Phe Leu Phe Val
         200                 205                 210

 cga aga aac cag ggg gct gag cag tgg cgc agt gcc caa ctt cta agc      727
 Arg Arg Asn Gln Gly Ala Glu Gln Trp Arg Ser Ala Gln Leu Leu Ser
     215                 220                 225

 ctc atc agc aac ccc cca gcc atg att aac cct gct aat tca gat aca      775
 Leu Ile Ser Asn Pro Pro Ala Met Ile Asn Pro Ala Asn Ser Asp Thr
 230                 235                 240                 245

 atg gcc tgt gag tat ctg tct gtg gaa gta atg gag cgc tgg att atc      823
 Met Ala Cys Glu Tyr Leu Ser Val Glu Val Met Glu Arg Trp Ile Ile
                 250                 255                 260

 att ggg ttt ctt ctt tgt cat ggg tgc ctc aac tcc aat agc cag tgc      871
 Ile Gly Phe Leu Leu Cys His Gly Cys Leu Asn Ser Asn Ser Gln Cys
             265                 270                 275

 cag aag ctg tgg aag ctg tgt ctg cag ggc tcc ctc tac atc acc ctt      919
 Gln Lys Leu Trp Lys Leu Cys Leu Gln Gly Ser Leu Tyr Ile Thr Leu
         280                 285                 290

 atc cgt gag gat gtg ctg cag gtg cac aaa gtc acc gag gac ctg ttt      967
 Ile Arg Glu Asp Val Leu Gln Val His Lys Val Thr Glu Asp Leu Phe
     295                 300                 305

 agc agt ttg aaa ggg tat ggc aag aga gtg gca gac ata aag gag agc     1015
 Ser Ser Leu Lys Gly Tyr Gly Lys Arg Val Ala Asp Ile Lys Glu Ser
 310                 315                 320                 325

 aag gaa cat gta att gca aac agt ggc cag ttt cat tgt caa cgg cgg     1063
 Lys Glu His Val Ile Ala Asn Ser Gly Gln Phe His Cys Gln Arg Arg
                 330                 335                 340

 caa ttt ctg cgg atg gca gtg aag gag ctg gag act gtg ttg gct gat     1111
 Gln Phe Leu Arg Met Ala Val Lys Glu Leu Glu Thr Val Leu Ala Asp
             345                 350                 355

 gaa ccg gga cta ctg ggt cct aag gct ctt ttt gct ttc atg gcc ctg     1159
 Glu Pro Gly Leu Leu Gly Pro Lys Ala Leu Phe Ala Phe Met Ala Leu
         360                 365                 370

 tcc ttc att cgt gat gag gtc acc tgg ctg gtt cgc cac aca gag aat     1207
 Ser Phe Ile Arg Asp Glu Val Thr Trp Leu Val Arg His Thr Glu Asn
     375                 380                 385

 gtc acc aag aca aag aca cct gag gac tat gct gac tcg agc att gca     1255
 Val Thr Lys Thr Lys Thr Pro Glu Asp Tyr Ala Asp Ser Ser Ile Ala
 390                 395                 400                 405

 gag cta ctt ttc ttg ttg gag ggg att agg tct ctg gtc cga aga cac     1303
 Glu Leu Leu Phe Leu Leu Glu Gly Ile Arg Ser Leu Val Arg Arg His
                 410                 415                 420

 atc aaa gtg ata cag caa tac cac ctt cag tac ttg gca aga ttt gat     1351
 Ile Lys Val Ile Gln Gln Tyr His Leu Gln Tyr Leu Ala Arg Phe Asp
             425                 430                 435

 gct ctt gtg ctc agt gac atc att cag aac ttg tct gtg tgt cca gag     1399
 Ala Leu Val Leu Ser Asp Ile Ile Gln Asn Leu Ser Val Cys Pro Glu
         440                 445                 450

 gag gag tcc atc atc atg tcc tca ttc gtc agt atc ctc tcc tct ctg     1447
 Glu Glu Ser Ile Ile Met Ser Ser Phe Val Ser Ile Leu Ser Ser Leu
     455                 460                 465

 aat ctc aaa caa gtt gat aat gga gaa aaa ttt gaa ttc tca gga ttg     1495
 Asn Leu Lys Gln Val Asp Asn Gly Glu Lys Phe Glu Phe Ser Gly Leu
 470                 475                 480                 485

 agg ctg gac tgg ttc cgc cta cag gca tac cat agc gtg gct aag gcc     1543
 Arg Leu Asp Trp Phe Arg Leu Gln Ala Tyr His Ser Val Ala Lys Ala
                 490                 495                 500

 cct ctg cac ctg cat gag aac cct gac tta gcc aag gtg atg aac ctc     1591
 Pro Leu His Leu His Glu Asn Pro Asp Leu Ala Lys Val Met Asn Leu
             505                 510                 515

 att gtc ttc cac tcc cga atg ctg gac tcc gta gaa aaa ttg ctg gtg     1639
 Ile Val Phe His Ser Arg Met Leu Asp Ser Val Glu Lys Leu Leu Val
         520                 525                 530

 gaa act tct gat ctg tct act ttc tgc ttt cat ctt cgt atc ttt gag     1687
 Glu Thr Ser Asp Leu Ser Thr Phe Cys Phe His Leu Arg Ile Phe Glu
     535                 540                 545

 aag atg ttt gcc atg acc ttg gag gaa tct gcc atg ttg cgt tat gcc     1735
 Lys Met Phe Ala Met Thr Leu Glu Glu Ser Ala Met Leu Arg Tyr Ala
 550                 555                 560                 565

 att gct ttc ccc ctg att tgt gct cac ttt gtc cac tgc act cat gag     1783
 Ile Ala Phe Pro Leu Ile Cys Ala His Phe Val His Cys Thr His Glu
                 570                 575                 580

 atg tgc cca gag gag tac ccc cac ctc aag aac cat ggt ctt cac cac     1831
 Met Cys Pro Glu Glu Tyr Pro His Leu Lys Asn His Gly Leu His His
             585                 590                 595

 tgc aac tcc ttc ctg gaa gag ttg gcc aag cag acc agc aat tgc gtc     1879
 Cys Asn Ser Phe Leu Glu Glu Leu Ala Lys Gln Thr Ser Asn Cys Val
         600                 605                 610

 ctg gag atc tgt gct gag cag cga aac ctg agc gag cag ctt cta cct     1927
 Leu Glu Ile Cys Ala Glu Gln Arg Asn Leu Ser Glu Gln Leu Leu Pro
     615                 620                 625

 aag cac tgt gcc act aca atc agc aaa gcc aag aac aag aaa acc agg     1975
 Lys His Cys Ala Thr Thr Ile Ser Lys Ala Lys Asn Lys Lys Thr Arg
 630                 635                 640                 645

 aag cag agg cag act ccc aga aaa gga gag ccc gag agg gac aag cca     2023
 Lys Gln Arg Gln Thr Pro Arg Lys Gly Glu Pro Glu Arg Asp Lys Pro
                 650                 655                 660

 gga gct gag agt cac cgg aag aac cgc agc att gtc acc aac atg gac     2071
 Gly Ala Glu Ser His Arg Lys Asn Arg Ser Ile Val Thr Asn Met Asp
             665                 670                 675

 aag cta cac cta aac ttg aca gaa ctg gca ctg aca atg aat cat gta     2119
 Lys Leu His Leu Asn Leu Thr Glu Leu Ala Leu Thr Met Asn His Val
         680                 685                 690

 tac agt ttc tcc gtg ttt gaa cat act atc ttc cct tct gag tac ctc     2167
 Tyr Ser Phe Ser Val Phe Glu His Thr Ile Phe Pro Ser Glu Tyr Leu
     695                 700                 705

 agc agc cac ctg gag gcc aga ctc aac aga gcc att gtg tgg ctg gct     2215
 Ser Ser His Leu Glu Ala Arg Leu Asn Arg Ala Ile Val Trp Leu Ala
 710                 715                 720                 725

 ggc tac aat gcc acg acc cag gag atc gta cgg cct tct gag ctg ttg     2263
 Gly Tyr Asn Ala Thr Thr Gln Glu Ile Val Arg Pro Ser Glu Leu Leu
                 730                 735                 740

 gca gga gtc aaa gca tac att ggt ttc ata cag tca ctg gcc cag ttt     2311
 Ala Gly Val Lys Ala Tyr Ile Gly Phe Ile Gln Ser Leu Ala Gln Phe
             745                 750                 755

 ttg ggt gca gat gct tcc aga gtc atc cgc aag ccc ctc ctg cag cag     2359
 Leu Gly Ala Asp Ala Ser Arg Val Ile Arg Lys Pro Leu Leu Gln Gln
         760                 765                 770

 aca caa cca ctg gat tcc tgt ggg gaa cag aca atc acc aca ctc tac     2407
 Thr Gln Pro Leu Asp Ser Cys Gly Glu Gln Thr Ile Thr Thr Leu Tyr
     775                 780                 785

 aca aac tgg tac ctg gaa agt ctg ctt aga cag gca agc agt ggg acc     2455
 Thr Asn Trp Tyr Leu Glu Ser Leu Leu Arg Gln Ala Ser Ser Gly Thr
 790                 795                 800                 805

 atc atc ctc tcc cca gcc atg cag gcc ttc gtc agc ctg ccc aga gaa     2503
 Ile Ile Leu Ser Pro Ala Met Gln Ala Phe Val Ser Leu Pro Arg Glu
                 810                 815                 820

 ggg gag cag aac ttc agt gca gag gag ttc tct gac atc tct gag atg     2551
 Gly Glu Gln Asn Phe Ser Ala Glu Glu Phe Ser Asp Ile Ser Glu Met
             825                 830                 835

 cgg gcc ttg gca gaa ctc ctg ggc ccc tat ggc atg aag ttc ctg agt     2599
 Arg Ala Leu Ala Glu Leu Leu Gly Pro Tyr Gly Met Lys Phe Leu Ser
         840                 845                 850

 gaa aac ctg atg tgg cat gtg acc tct cag att gtg gag ctg aag aag     2647
 Glu Asn Leu Met Trp His Val Thr Ser Gln Ile Val Glu Leu Lys Lys
     855                 860                 865

 ctg gtg gtg gaa aac atg gac ata ctt gtt cag atc aga tcc aac ttt     2695
 Leu Val Val Glu Asn Met Asp Ile Leu Val Gln Ile Arg Ser Asn Phe
 870                 875                 880                 885

 agc aag ccg gac ttg atg gct tcc ctg ctg ccc cag ctg aca ggg gct     2743
 Ser Lys Pro Asp Leu Met Ala Ser Leu Leu Pro Gln Leu Thr Gly Ala
                 890                 895                 900

 gaa aat gtg cta aag cgc atg acc atc att ggg gtt atc ctc agt ttc     2791
 Glu Asn Val Leu Lys Arg Met Thr Ile Ile Gly Val Ile Leu Ser Phe
             905                 910                 915

 agg gcc atg gcc caa gag gga ctt cgg gag gtt ttc tcc tcc cac tgc     2839
 Arg Ala Met Ala Gln Glu Gly Leu Arg Glu Val Phe Ser Ser His Cys
         920                 925                 930

 cca ttt ctt atg ggt ccc att gag tgc ttg aag gag ttt gtc act cca     2887
 Pro Phe Leu Met Gly Pro Ile Glu Cys Leu Lys Glu Phe Val Thr Pro
     935                 940                 945

 gac aca gac atc aag gtg acc ttg agt atc ttt gag ctg gca tct gct     2935
 Asp Thr Asp Ile Lys Val Thr Leu Ser Ile Phe Glu Leu Ala Ser Ala
 950                 955                 960                 965

 gca ggt gtg ggc tgt gac att gac cca gcc ttg gtg gct gcc att gct     2983
 Ala Gly Val Gly Cys Asp Ile Asp Pro Ala Leu Val Ala Ala Ile Ala
                 970                 975                 980

 aat ctg aaa gct gat act tca tct cct gag gag gaa tat aag gtg gcc     3031
 Asn Leu Lys Ala Asp Thr Ser Ser Pro Glu Glu Glu Tyr Lys Val Ala
             985                 990                 995

 tgc ctg ctc ttg atc ttt ctg gca gtt tcc ctc cca ctc ctt gcc act     3079
 Cys Leu Leu Leu Ile Phe Leu Ala Val Ser Leu Pro Leu Leu Ala Thr
        1000                1005                1010

 gac cct tct tcc ttt tat agc att gag aag gat ggt tac aac aac aat     3127
 Asp Pro Ser Ser Phe Tyr Ser Ile Glu Lys Asp Gly Tyr Asn Asn Asn
    1015                1020                1025

 att cat tgc ttg acc aaa gcc atc atc cag gtg tct gct gcc ctc ttc     3175
 Ile His Cys Leu Thr Lys Ala Ile Ile Gln Val Ser Ala Ala Leu Phe
1030                1035                1040                1045

 acg ctc tac aac aag aac att gaa act cac ctc aag gaa ttt ctg gtg     3223
 Thr Leu Tyr Asn Lys Asn Ile Glu Thr His Leu Lys Glu Phe Leu Val
                1050                1055                1060

 gtg gcc tct gtc agc ctc ttg cag ctg ggc cag gag act gac aag ctt     3271
 Val Ala Ser Val Ser Leu Leu Gln Leu Gly Gln Glu Thr Asp Lys Leu
            1065                1070                1075

 aaa acc aga aat cga gaa tcc att tct ctg ctc atg cgc ttg gtg gtg     3319
 Lys Thr Arg Asn Arg Glu Ser Ile Ser Leu Leu Met Arg Leu Val Val
        1080                1085                1090

 gag gag tca tcc ttc ctg acc ctg gac atg ctg gag tcc tgt ttc cct     3367
 Glu Glu Ser Ser Phe Leu Thr Leu Asp Met Leu Glu Ser Cys Phe Pro
    1095                1100                1105

 tat gtc ctg ctt cga aat gcc tat cgg gag gtg tct cgg gcc ttc cac     3415
 Tyr Val Leu Leu Arg Asn Ala Tyr Arg Glu Val Ser Arg Ala Phe His
1110                1115                1120                1125

 cta aac tga atgcctg ccagtaccca ctgaagagcc ctttggacct tcctaaaccc     3471
 Leu Asn 






      <210> 417
      <211> 1645
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (256)..(1551)

      <400> 417
 atggcttctt cctctctcat ggatcattct ttctgggaga agtttaccca ccaagtcctg     60

 aagacattga agcaacccta tggaaagatc catgcggcag gcgccgttgc cgaccaaacg    120

 cccaggttca cccaacgcca gaggctcgtc ctcaattccc gcgaggcccc cggaggtgct    180

 ggggtccctg cagggccggg ccacctgccg tggagctcag gccgcgccag aatcggatcc    240

 gggaagctgc gcgcc atg agc agc tcc ctg cgg ccg ggc ccc agc cgc tgg     291
                  Met Ser Ser Ser Leu Arg Pro Gly Pro Ser Arg Trp
                    1               5                  10

 cgg cgg gcg gcc agc atc gtc ctg gcg gct ggc tgg tcg cgc ccg gag      339
 Arg Arg Ala Ala Ser Ile Val Leu Ala Ala Gly Trp Ser Arg Pro Glu
          15                  20                  25

 acc gcc acc ccg ccg tcg cgc ccg ccg ccg gcc gag ggc ttc cgg ctg      387
 Thr Ala Thr Pro Pro Ser Arg Pro Pro Pro Ala Glu Gly Phe Arg Leu
      30                  35                  40

 ctg ctg ctg cag cgc tcc ccg cac caa ggc ttc atg ccg ggc gcg cac      435
 Leu Leu Leu Gln Arg Ser Pro His Gln Gly Phe Met Pro Gly Ala His
  45                  50                  55                  60

 gtc ttc tcc ggc gga gtg ctg gat gcg gcc gac cgc tcg gcg gac tgg      483
 Val Phe Ser Gly Gly Val Leu Asp Ala Ala Asp Arg Ser Ala Asp Trp
                  65                  70                  75

 ctg ggc ctc ttc gcg ccg cac cac ggg ccg ccg cgc ttc ggc ctg ggc      531
 Leu Gly Leu Phe Ala Pro His His Gly Pro Pro Arg Phe Gly Leu Gly
              80                  85                  90

 ccg gcg cca ttc agc cgc acc gct ttc ccg tcg ctg ccc gac acc gat      579
 Pro Ala Pro Phe Ser Arg Thr Ala Phe Pro Ser Leu Pro Asp Thr Asp
          95                 100                 105

 gac cac aag acc gac aac act ggg acg ctg cct gag gac gta gcc ttc      627
 Asp His Lys Thr Asp Asn Thr Gly Thr Leu Pro Glu Asp Val Ala Phe
     110                 115                 120

 cgc atc tgc gcc gtg cgg gag gcc ttt gag gag gcg ggc gtg ctg ctg      675
 Arg Ile Cys Ala Val Arg Glu Ala Phe Glu Glu Ala Gly Val Leu Leu
 125                 130                 135                 140

 ctg cgg ccc agg act tcc cca cca ggc cca gca ccc ggg cct ggc ctc      723
 Leu Arg Pro Arg Thr Ser Pro Pro Gly Pro Ala Pro Gly Pro Gly Leu
                 145                 150                 155

 gcc ctg gag cca ccg ccg ggc ctg gcc tcc tgg cgc gac cgc gtg cgc      771
 Ala Leu Glu Pro Pro Pro Gly Leu Ala Ser Trp Arg Asp Arg Val Arg
             160                 165                 170

 cag gac ccg cgc cac ttc ctg cgg ctg tgc gcc cac ctc gac tgc aca      819
 Gln Asp Pro Arg His Phe Leu Arg Leu Cys Ala His Leu Asp Cys Thr
         175                 180                 185

 ccc gac atc tgg gcg ctg cac aac tgg agc gcc tgg ctc acc cct ttc      867
 Pro Asp Ile Trp Ala Leu His Asn Trp Ser Ala Trp Leu Thr Pro Phe
     190                 195                 200

 ttg cgg ggc acc act cgc cgc ttt gac acg gcc ttc ttc ctg tgc tgc      915
 Leu Arg Gly Thr Thr Arg Arg Phe Asp Thr Ala Phe Phe Leu Cys Cys
 205                 210                 215                 220

 ctg cgc gag ccg ccg ccc gtc tac ccc gac ttg gcg gag gtg gtg ggc      963
 Leu Arg Glu Pro Pro Pro Val Tyr Pro Asp Leu Ala Glu Val Val Gly
                 225                 230                 235

 tac cag tgg tca tct cca tca gag gca act gaa agt ttc tta tca aaa     1011
 Tyr Gln Trp Ser Ser Pro Ser Glu Ala Thr Glu Ser Phe Leu Ser Lys
             240                 245                 250

 gaa att tgg ttg cca ccc cca cag ttc tac gaa gtg aga aga ctt gca     1059
 Glu Ile Trp Leu Pro Pro Pro Gln Phe Tyr Glu Val Arg Arg Leu Ala
         255                 260                 265

 aac ttt gcc tct ctc tct gac ttg cac aaa ttt tgt ttg ggt cgt gca     1107
 Asn Phe Ala Ser Leu Ser Asp Leu His Lys Phe Cys Leu Gly Arg Ala
     270                 275                 280

 tta gaa gga ctg gaa agg tgg ctg ccg atc atc ttg tta act gct gat     1155
 Leu Glu Gly Leu Glu Arg Trp Leu Pro Ile Ile Leu Leu Thr Ala Asp
 285                 290                 295                 300

 ggg atg gtc cat ctt tta cca ggt gat gag cta tat tta gaa gat tca     1203
 Gly Met Val His Leu Leu Pro Gly Asp Glu Leu Tyr Leu Glu Asp Ser
                 305                 310                 315

 gac ttt ttg gaa aat ctt atg tct act gaa aaa aag act gag gaa atc     1251
 Asp Phe Leu Glu Asn Leu Met Ser Thr Glu Lys Lys Thr Glu Glu Ile
             320                 325                 330

 atg aag gaa ggc aag cag ttt cac cgg ata gtg aca tac cat cgc cac     1299
 Met Lys Glu Gly Lys Gln Phe His Arg Ile Val Thr Tyr His Arg His
         335                 340                 345

 ctt tat gat atc cac gtg act gtt cag cca aag tat aaa cac gtt tat     1347
 Leu Tyr Asp Ile His Val Thr Val Gln Pro Lys Tyr Lys His Val Tyr
     350                 355                 360

 cct aag aac tct gta caa att aac tcg ttt aga ctc gga gag ccc tgc     1395
 Pro Lys Asn Ser Val Gln Ile Asn Ser Phe Arg Leu Gly Glu Pro Cys
 365                 370                 375                 380

 cag ttg aag tcc agc tgg gaa gaa atc cag gac cag gaa cct ttc caa     1443
 Gln Leu Lys Ser Ser Trp Glu Glu Ile Gln Asp Gln Glu Pro Phe Gln
                 385                 390                 395

 aag gtg cag atc aaa tgg aaa tgt tgc cag gag gcc acg aag acc cag     1491
 Lys Val Gln Ile Lys Trp Lys Cys Cys Gln Glu Ala Thr Lys Thr Gln
             400                 405                 410

 gga ttc atg act gtc cag gac tct tcc tca cca cca agg ctt cca gct     1539
 Gly Phe Met Thr Val Gln Asp Ser Ser Ser Pro Pro Arg Leu Pro Ala
         415                 420                 425

 cac agc gtt taa ggg gtgtaggctg gcctagagaa agcaggagga caggggcccc     1594
 His Ser Val 
     430

 ttagcaggca acaaggacca actgagggcc tggtgtggtg gttcatgcct g            1645




      <210> 418
      <211> 834
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (292)..(783)

      <400> 418
 tgagtgccct ccgctttttg tggccaaacc cagccacgca gttcccttcc tgcggcgtcc     60

 tccacacccg gggtctgctg gtctccgcgg atgtcacagg ctcggcaacc gccctcctgt    120

 cggcggggag tcccgcgacg cccggaaatg ctccgaagcc tgtcgctcag ctgccagatc    180

 tgcgtctgtg tccggttccg tcactgaggt cgcccctgtc cggcccttcc tccctagttc    240

 tcttcaccgt ccgcccatcc tatcgcgcgc ggcctcaggt ccccattcgg c atg tgg     297
                                                          Met Trp
                                                            1

 ctt gtc ttc cat cgt ccc cac cct cgc ccc tct tgg ccc ctc agg gca      345
 Leu Val Phe His Arg Pro His Pro Arg Pro Ser Trp Pro Leu Arg Ala
           5                  10                  15

 gcc ctg gga ttc ggc aga cgc cag tcc tcc ctg aga tgc ttc ccc gtc      393
 Ala Leu Gly Phe Gly Arg Arg Gln Ser Ser Leu Arg Cys Phe Pro Val
      20                  25                  30

 ctt ccc tcc gcc agg ccc tac gtc tcc gca aac ccc acg ctt cgg ggt      441
 Leu Pro Ser Ala Arg Pro Tyr Val Ser Ala Asn Pro Thr Leu Arg Gly
  35                  40                  45                  50

 ggc cgc ctc aga cag gac cct gag tcc gag act ggg gta ggg gac ctg      489
 Gly Arg Leu Arg Gln Asp Pro Glu Ser Glu Thr Gly Val Gly Asp Leu
                  55                  60                  65

 ccc gat cct gta aca acc ctc gtg ctt ctg cac aat cgc ctc cca cta      537
 Pro Asp Pro Val Thr Thr Leu Val Leu Leu His Asn Arg Leu Pro Leu
              70                  75                  80

 gcg gtg act gtt ggg tgt cta cct tcc cgg tgt ccc act gag aag cgg      585
 Ala Val Thr Val Gly Cys Leu Pro Ser Arg Cys Pro Thr Glu Lys Arg
          85                  90                  95

 gct ctt cct tgg cag ggg ctt ctt cat tgc ctc gct gtg gat gtc gag      633
 Ala Leu Pro Trp Gln Gly Leu Leu His Cys Leu Ala Val Asp Val Glu
     100                 105                 110

 gtg ggg cag gag agt gag gag aaa aca gag agg agg gag gta gag cca      681
 Val Gly Gln Glu Ser Glu Glu Lys Thr Glu Arg Arg Glu Val Glu Pro
 115                 120                 125                 130

 acg agc gag aaa agg gga ggg aag ttt aga tgg gaa gtg gat ggg tct      729
 Thr Ser Glu Lys Arg Gly Gly Lys Phe Arg Trp Glu Val Asp Gly Ser
                 135                 140                 145

 gag gaa ttt gaa caa aca ccg aca gtg aag gag agt gac ctg agc aag      777
 Glu Glu Phe Glu Gln Thr Pro Thr Val Lys Glu Ser Asp Leu Ser Lys
             150                 155                 160

 cag tag tggggtaaat ggaaatagac aaaatgggaa tcagcagaga tatggaggac       833
 Gln 


 a                                                                    834




      <210> 419
      <211> 827
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (174)..(827)

      <400> 419
 cgtcggggac agtcaccctc ccggaatggg gcttcctttc tcggggctgg gaatcaccct     60

 ggatccctcc ccactcgggg tgctcttggg ccatctgagg gctcctgggt cactcttggg    120

 ccttctcagg gttcctgggt cattcttggg ccatctgagg gttcctgagc cca   atg     176
                                                              Met
                                                                1

 aca ctt ctg cct agg ctc gcg ctg cgg gag gaa gaa gcc agg cga ggt      224
 Thr Leu Leu Pro Arg Leu Ala Leu Arg Glu Glu Glu Ala Arg Arg Gly
               5                  10                  15

 ccc ctc cgt gcc ccg gtg cag cct ggc ctg gga gag agg agc ccc cag      272
 Pro Leu Arg Ala Pro Val Gln Pro Gly Leu Gly Glu Arg Ser Pro Gln
          20                  25                  30

 cga cac cga gag cca aaa cag ggc aga gtt tct cag agg tgg cac ccg      320
 Arg His Arg Glu Pro Lys Gln Gly Arg Val Ser Gln Arg Trp His Pro
      35                  40                  45

 gcc agg gag ccc ctc gcg gct aca ggg ttt ctc cac gga ctc ggc cat      368
 Ala Arg Glu Pro Leu Ala Ala Thr Gly Phe Leu His Gly Leu Gly His
  50                  55                  60                  65

 ctg ggg aga gca gcc cag agc cct cga gcc tcc tgc tgt att ctg tgg      416
 Leu Gly Arg Ala Ala Gln Ser Pro Arg Ala Ser Cys Cys Ile Leu Trp
                  70                  75                  80

 cct ggg act tgg ggg gac cca ttg agg aca ctg gga cgc agc caa agg      464
 Pro Gly Thr Trp Gly Asp Pro Leu Arg Thr Leu Gly Arg Ser Gln Arg
              85                  90                  95

 gag gtg cag aca gtg tgt act ggc gtt tcc ggg gac caa gcc cag aag      512
 Glu Val Gln Thr Val Cys Thr Gly Val Ser Gly Asp Gln Ala Gln Lys
         100                 105                 110

 gag cag gac ggc cac ctc ctg gcc tgg agg aaa atc ctg ctt cct ggc      560
 Glu Gln Asp Gly His Leu Leu Ala Trp Arg Lys Ile Leu Leu Pro Gly
     115                 120                 125

 aag aaa acc acc cct aga gga ata gga ctg ggg tgc agg acg ctt tct      608
 Lys Lys Thr Thr Pro Arg Gly Ile Gly Leu Gly Cys Arg Thr Leu Ser
 130                 135                 140                 145

 cag gca acc gcc cct ttc ctt ctc caa aac tgg ggc agg aaa aga gca      656
 Gln Ala Thr Ala Pro Phe Leu Leu Gln Asn Trp Gly Arg Lys Arg Ala
                 150                 155                 160

 ttc agg cca ggc agc gaa aac ccc agc tct ggt acc tcc cgc ccc agc      704
 Phe Arg Pro Gly Ser Glu Asn Pro Ser Ser Gly Thr Ser Arg Pro Ser
             165                 170                 175

 aga ggc cgc ctg gag gca cgg agt tcc ggc ctg gat gag gcc tgg gaa      752
 Arg Gly Arg Leu Glu Ala Arg Ser Ser Gly Leu Asp Glu Ala Trp Glu
         180                 185                 190

 gcc cag cga ctc aca ggc cac ggc cgc ttc ccc tct ccg agg aag gaa      800
 Ala Gln Arg Leu Thr Gly His Gly Arg Phe Pro Ser Pro Arg Lys Glu
     195                 200                 205

 aag tcc ctg cag cgc ggc ctc ggc taa                                  827
 Lys Ser Leu Gln Arg Gly Leu Gly 
 210                 215





      <210> 420
      <211> 1407
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (551)..(1165)

      <400> 420
 ctcttttttc ctctgggctc taagagcccc gcaggctgta cctgcggatt tcccctctca     60

 gccaactcca gcctctgctc cccctctgct cctcacttct ctaaagcgaa acatctcaca    120

 gtcatttgct ccatgcttcc tgtacgattt ctttattttt actctccagt ttgtgggctg    180

 agtctgtgtg ggtgtgggag agggctgggt atttctactt ctctgcattt tccttctgag    240

 ctgggaggac tttcacttcc tccccagtct ctcagttctg cctttcatgg gctgttcagg    300

 ccatgagacc acctctccta atccttcctg agcaccaggg aaatggaaaa ctgactgtaa    360

 ctggctgccc tggaagggcc tagcatccac tcaggagcaa caggtggtgg caactacagc    420

 agtaacagta acctccctgg ggcaggagcc ttgggctggc gtgacagcag cagaggcagc    480

 caagggagcc ctgcttgctc ctgaggccat ccgagccctg gaacctgtct tgcatccctc    540

 taacaccacc   atg ggc aag cct ggg cct cca ctt ccc tcc ctc agc ctt     589
              Met Gly Lys Pro Gly Pro Pro Leu Pro Ser Leu Ser Leu
                1               5                  10

 ttc tgt ccc agc act cag cca gac aag agt gac tct cag ctt gcc cca      637
 Phe Cys Pro Ser Thr Gln Pro Asp Lys Ser Asp Ser Gln Leu Ala Pro
      15                  20                  25

 atg ccc cca gct ctg cct gct gat cta gtt cta tat ttg aga gtc tta      685
 Met Pro Pro Ala Leu Pro Ala Asp Leu Val Leu Tyr Leu Arg Val Leu
  30                  35                  40                  45

 gac atc tac cac act gga gca cag agc cac ggg agg ggt tgg cct cca      733
 Asp Ile Tyr His Thr Gly Ala Gln Ser His Gly Arg Gly Trp Pro Pro
                  50                  55                  60

 tca ccg ggg cct gac aac ctg cca tcc cgc cat ccc aac ctc cct gaa      781
 Ser Pro Gly Pro Asp Asn Leu Pro Ser Arg His Pro Asn Leu Pro Glu
              65                  70                  75

 cct cag tct cct ctt tca aac aaa gtt ata tgt aga tac agt gga gga      829
 Pro Gln Ser Pro Leu Ser Asn Lys Val Ile Cys Arg Tyr Ser Gly Gly
          80                  85                  90

 tta gaa aac att gaa tgg gtg ccc caa tca aca gtg tct gtt act ggc      877
 Leu Glu Asn Ile Glu Trp Val Pro Gln Ser Thr Val Ser Val Thr Gly
      95                 100                 105

 agg agt tat aaa tgt gta ttg aaa tgg aat ccc ttc ttt ttt tct tcc      925
 Arg Ser Tyr Lys Cys Val Leu Lys Trp Asn Pro Phe Phe Phe Ser Ser
 110                 115                 120                 125

 aat cat aag gac cac aac cat cca aaa agc aaa gag agc ctc aga cac      973
 Asn His Lys Asp His Asn His Pro Lys Ser Lys Glu Ser Leu Arg His
                 130                 135                 140

 tcc agc tca gcc tct agt tgc aga aag tca cct cct caa ggg gag aga     1021
 Ser Ser Ser Ala Ser Ser Cys Arg Lys Ser Pro Pro Gln Gly Glu Arg
             145                 150                 155

 tca gtg ttc act agg act gga att cag tgt gat cta gtg gtt gaa agt     1069
 Ser Val Phe Thr Arg Thr Gly Ile Gln Cys Asp Leu Val Val Glu Ser
         160                 165                 170

 ctt agc ttc agc ctc ccc agc ctg tca gct gtt cca gaa gcc tgt cag     1117
 Leu Ser Phe Ser Leu Pro Ser Leu Ser Ala Val Pro Glu Ala Cys Gln
     175                 180                 185

 ctg ccc ctt agt ttt ctg ctg tgt cct caa aga agc atg gga ccc taa     1165
 Leu Pro Leu Ser Phe Leu Leu Cys Pro Gln Arg Ser Met Gly Pro 
 190                 195                 200

 aataaacctc tggagagcca gttgcccact cttccagaag agagactaga cacgcagctg   1225

 ggcatgcggc cagagcccaa gaaaagcctg gtttgccagg ggcagattac agtcaacggg   1285

 agcagtaagt gcctctgccc tctcctcacg ggtccttctc ttttctagag gggagtccag   1345

 cacgtgccag ccccaggagg tctcactccc ttgccagcct cccgactcaa ttcccaggac   1405

 tc                                                                  1407




      <210> 421
      <211> 582
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (232)..(531)

      <400> 421
 agcccactcg cacccgggtg aataaacagc ctttgttgct cacacttagc ctgttcaagt     60

 tgtctcttca attagatgct cgcataacat ttggtgccga aagcccggga taggggaact    120

 cctccggcag acctctcctc tatcctcccg gtacccacgt tctcccatgc aagagacttc    180

 cctcgccctc aggacctcag accagctccg cgagcactcc ggcctctgtc t atg gat     237
                                                          Met Asp
                                                            1

 atg aaa tcc aac acc ggt cac gga ctc ttc ttg ggg aga cag cct tcc      285
 Met Lys Ser Asn Thr Gly His Gly Leu Phe Leu Gly Arg Gln Pro Ser
           5                  10                  15

 ttc agt gtt tgg tca atg ccc ggg acg ccc gcc ttg gcc att tgc cag      333
 Phe Ser Val Trp Ser Met Pro Gly Thr Pro Ala Leu Ala Ile Cys Gln
      20                  25                  30

 cca cac aac cca gga cct cca atg ggg acg ccc act gag gat cct agt      381
 Pro His Asn Pro Gly Pro Pro Met Gly Thr Pro Thr Glu Asp Pro Ser
  35                  40                  45                  50

 ggt tgc tct ttt cct tgt ctc ttt ctt tcc ccc cag tct ttc ctt gtt      429
 Gly Cys Ser Phe Pro Cys Leu Phe Leu Ser Pro Gln Ser Phe Leu Val
                  55                  60                  65

 cta tca tgg gca att tcc cgc ctt cca tcc ctc ttt ctt ctg tct ggc      477
 Leu Ser Trp Ala Ile Ser Arg Leu Pro Ser Leu Phe Leu Leu Ser Gly
              70                  75                  80

 ttg tgt cct cag aaa cct caa acc tct tca cct tgc acc caa tct aaa      525
 Leu Cys Pro Gln Lys Pro Gln Thr Ser Ser Pro Cys Thr Gln Ser Lys
          85                  90                  95

 ggc taa acgtctaatt tttttctgta acacgtcctg gccccagtat aaattagaaa       581
 Gly 


 a                                                                    582




      <210> 422
      <211> 971
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (129)..(971)

      <400> 422
 tttcgtgggc ccggcctcca ggagcgccag gcagaaaggg cacccattag gaagaagaac     60

 acagaggcca tgggagtgaa aagtttgatg ctggaaagca acagtagcac attctgctac    120

 agagcgga atg aaa aac cct ggg gag caa att cct gag cca gag aat gga     170
          Met Lys Asn Pro Gly Glu Gln Ile Pro Glu Pro Glu Asn Gly
            1               5                  10

 gcg gag gaa cca gcc aag gag gat aaa gag gtg gga aca ggc aag aaa      218
 Ala Glu Glu Pro Ala Lys Glu Asp Lys Glu Val Gly Thr Gly Lys Lys
  15                  20                  25                  30

 acc tgg gtg cgt gca cgc att gac atc cac ctg cat aac ttt tac cag      266
 Thr Trp Val Arg Ala Arg Ile Asp Ile His Leu His Asn Phe Tyr Gln
                  35                  40                  45

 gta tgt cag gag ctg ggc tcc acc agg gag act caa gtg gaa agc cct      314
 Val Cys Gln Glu Leu Gly Ser Thr Arg Glu Thr Gln Val Glu Ser Pro
              50                  55                  60

 cat cct tgt cct cca gga gac agg aaa acc tat ggt tac aat tcc agg      362
 His Pro Cys Pro Pro Gly Asp Arg Lys Thr Tyr Gly Tyr Asn Ser Arg
          65                  70                  75

 gac aag agc gat gca tgt gag gac tgg gcg ttc atc aac acc aac atc      410
 Asp Lys Ser Asp Ala Cys Glu Asp Trp Ala Phe Ile Asn Thr Asn Ile
      80                  85                  90

 ttt gcc agg acc aag ata gac ccc agc gcc ttg gtg cag aag ctg gag      458
 Phe Ala Arg Thr Lys Ile Asp Pro Ser Ala Leu Val Gln Lys Leu Glu
  95                 100                 105                 110

 ctg gac gta agg agc gtc act tcc atc agg aga ggt gca gag gcc aag      506
 Leu Asp Val Arg Ser Val Thr Ser Ile Arg Arg Gly Ala Glu Ala Lys
                 115                 120                 125

 acc gtt ttg ccc aag gag aaa atg aag ctg agg cgt gag caa tgg ttg      554
 Thr Val Leu Pro Lys Glu Lys Met Lys Leu Arg Arg Glu Gln Trp Leu
             130                 135                 140

 cag aaa atc gaa gcc ata aaa ctg gct gag cag aag cac agg gag gag      602
 Gln Lys Ile Glu Ala Ile Lys Leu Ala Glu Gln Lys His Arg Glu Glu
         145                 150                 155

 cgg agg cgg agg gcc acg gtg gtg gtg ggg gac ctg cac cct ctc agg      650
 Arg Arg Arg Arg Ala Thr Val Val Val Gly Asp Leu His Pro Leu Arg
     160                 165                 170

 gat gcc ctg ccc gag ctg ctg ggg ctc gag gct ggc agc cgg cgc caa      698
 Asp Ala Leu Pro Glu Leu Leu Gly Leu Glu Ala Gly Ser Arg Arg Gln
 175                 180                 185                 190

 gcc cgc aga acc cca tca ccc agt gac aca acc ccg cca ccc agt gac      746
 Ala Arg Arg Thr Pro Ser Pro Ser Asp Thr Thr Pro Pro Pro Ser Asp
                 195                 200                 205

 gca acc ccc agt gac aca acc ctg cca ccc ggt gac gca acc ccc agt      794
 Ala Thr Pro Ser Asp Thr Thr Leu Pro Pro Gly Asp Ala Thr Pro Ser
             210                 215                 220

 gac aca acc ccc agt gac gca acc ccg cca ccc aat gaa gat acc acc      842
 Asp Thr Thr Pro Ser Asp Ala Thr Pro Pro Pro Asn Glu Asp Thr Thr
         225                 230                 235

 acc cgc gag gaa gaa agg acc cgg ttt cag gag ctg ctg gcc agt ccg      890
 Thr Arg Glu Glu Glu Arg Thr Arg Phe Gln Glu Leu Leu Ala Ser Pro
     240                 245                 250

 gcc tac aga gcc agc ccc ctg gtg gcc atc ggg cag acg ctg gcc cgg      938
 Ala Tyr Arg Ala Ser Pro Leu Val Ala Ile Gly Gln Thr Leu Ala Arg
 255                 260                 265                 270

 cag atg cag ctg gaa gat ggc ggc cag ctc tga                          971
 Gln Met Gln Leu Glu Asp Gly Gly Gln Leu 
                 275                 280





      <210> 423
      <211> 735
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (107)..(631)

      <400> 423
 ttccgggtcg acgatctcgt gctgcttgcg ccccagcgcg cgcccaggcg ccttggaatc     60

 cccgtccttg ggcccccgca aggtccccgg ccgtgcgcga ggcagc   atg atg agg     115
                                                      Met Met Arg
                                                        1

 cgc acc ctg gaa aac cgg aac gct caa acg aaa caa ctg caa aca gct      163
 Arg Thr Leu Glu Asn Arg Asn Ala Gln Thr Lys Gln Leu Gln Thr Ala
       5                  10                  15

 gtc tca aat gtg gag aag cat ttt gga gaa ctg tgc caa atc ttc gct      211
 Val Ser Asn Val Glu Lys His Phe Gly Glu Leu Cys Gln Ile Phe Ala
  20                  25                  30                  35

 gcc tat gtg cgg aaa act gcc agg ctg aga gac aaa gca gac ctc ctg      259
 Ala Tyr Val Arg Lys Thr Ala Arg Leu Arg Asp Lys Ala Asp Leu Leu
                  40                  45                  50

 gtg aat gaa att aac gcg tat gct gct aca gag acc ccg cat tta aag      307
 Val Asn Glu Ile Asn Ala Tyr Ala Ala Thr Glu Thr Pro His Leu Lys
              55                  60                  65

 ctg ggc ctg atg aac ttt gca gat gag ttt gcc aaa ctt cag gat tat      355
 Leu Gly Leu Met Asn Phe Ala Asp Glu Phe Ala Lys Leu Gln Asp Tyr
          70                  75                  80

 cga caa gca gag gtt gaa aga ctt gaa gcc aaa gta gtt gaa ccc ttg      403
 Arg Gln Ala Glu Val Glu Arg Leu Glu Ala Lys Val Val Glu Pro Leu
      85                  90                  95

 aaa act tat ggg acc att gtg aaa atg aaa cgg gat gac ctc aaa gca      451
 Lys Thr Tyr Gly Thr Ile Val Lys Met Lys Arg Asp Asp Leu Lys Ala
 100                 105                 110                 115

 aca ctc aca gca agg aat cga gaa gct aag caa tta act cag tta gaa      499
 Thr Leu Thr Ala Arg Asn Arg Glu Ala Lys Gln Leu Thr Gln Leu Glu
                 120                 125                 130

 aga aca cgt cag cga aac cca tct gat cga cat gtt att tca cag gca      547
 Arg Thr Arg Gln Arg Asn Pro Ser Asp Arg His Val Ile Ser Gln Ala
             135                 140                 145

 gaa acg gaa tta cag aga gct gca atg gat gct agc cga aca agt cgt      595
 Glu Thr Glu Leu Gln Arg Ala Ala Met Asp Ala Ser Arg Thr Ser Arg
         150                 155                 160

 cat ctg gag gaa act att aac aac ttt gaa agg tag aaaa tgaaggatat      645
 His Leu Glu Glu Thr Ile Asn Asn Phe Glu Arg 
     165                 170

 aaagactata ttttctgaat ttatcacaat cgaaatgtta tttcacggga aagctttaga    705

 ggtctacact gctgcctacc cagatatacg                                     735




      <210> 424
      <211> 456
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(416)

      <400> 424
 tttcgtgcgc gtggctgcag cggggcccgc gtggtgcccc ctgaggcggc ccccgg         56                                                                 
 atg aag aga tct ggg aac ccg gga gcc gag gta acg aac agc tcg gtg      104
 Met Lys Arg Ser Gly Asn Pro Gly Ala Glu Val Thr Asn Ser Ser Val
   1               5                  10                  15

 gca ggg cct gac tgc tgc gga ggc ctc ggc aat att gat ttt aga cag      152
 Ala Gly Pro Asp Cys Cys Gly Gly Leu Gly Asn Ile Asp Phe Arg Gln
              20                  25                  30

 gca gac ttc tgc gtt atg acc cgg ctg ctg ggc tac gtg gac ccc ctg      200
 Ala Asp Phe Cys Val Met Thr Arg Leu Leu Gly Tyr Val Asp Pro Leu
          35                  40                  45

 gat ccc agc ttt gtg gct gcc gtc atc acc atc acc ttc aat ccg ctc      248
 Asp Pro Ser Phe Val Ala Ala Val Ile Thr Ile Thr Phe Asn Pro Leu
      50                  55                  60

 tac tgg aat gtg gta agt gat gtg cct gac act gtc cag acg gga gta      296
 Tyr Trp Asn Val Val Ser Asp Val Pro Asp Thr Val Gln Thr Gly Val
  65                  70                  75                  80

 tct cac tgc ttg gtg agc ccc aca tgc agg gga tcg cgg tgg ttg ctg      344
 Ser His Cys Leu Val Ser Pro Thr Cys Arg Gly Ser Arg Trp Leu Leu
                  85                  90                  95

 ctg gct ggc cag aca gac aga cag ctc tgc tct tcc ctc ccg tgt ctg      392
 Leu Ala Gly Gln Thr Asp Arg Gln Leu Cys Ser Ser Leu Pro Cys Leu
             100                 105                 110

 tcg ctg gct ggt gtg gag tac tag gcgcttcctg ccgtcttgcc ttgaggatcc     446
 Ser Leu Ala Gly Val Glu Tyr 
         115

 agcagccatt                                                           456




      <210> 425
      <211> 532
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (408)..(497)

      <220>
      <221> misc_feature
      <222> (1)...(532)
      <223> n = a,t,c or g

      <400> 425
 ccagggtggg cccagtgggc cttctgggtc ttgncggctc tcagaacagg gaagcagggg     60

 gtgccctgcc tgccgtggag gctccggaca cgatctgtgg ccagggtctg agtgactgag    120

 cgtggccagg tcggctctgc ttctgcaact cctcgtgtgc ttatgagtgg acgccctgcc    180

 ctgccttact tcagggaccc ctcacgccct gccccctgcc tcactgcagg gaccactctg    240

 ctcccaattg tccacccaga gaccctccac agcggccacc tgaccactgg ctttcaatgg    300

 aactctctcc cgcgataggc cgagggcctt ggtgacctcc agctcactca gtctcaggga    360

 gccccagggt ttcagcacat ccttctagag tctttccagc tgcaccc  atg agg ctg     416
                                                      Met Arg Leu
                                                        1

 ggg cca ggt gaa gac aga gaa gca tcc agg agc cca cat cta agg agg      464
 Gly Pro Gly Glu Asp Arg Glu Ala Ser Arg Ser Pro His Leu Arg Arg
       5                  10                  15

 ccc cca ctc cca gcg cca tcc gaa tgc agg tag gtcgtcgt agcggccgcg      515
 Pro Pro Leu Pro Ala Pro Ser Glu Cys Arg 
  20                  25

 aatttagtag tagtagg                                                   532




      <210> 426
      <211> 2326
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (268)..(2145)

      <400> 426
 tttcgtcgga ggggcgcgag cgcgcggcaa atcgggcggg aagaggtaaa aaaggaactg     60

 ggagcgagcc gcggcggttc ctgtccttac agttgcgctg cccagggacc gatgttgcgc    120

 gaggaaaatg cgggactccc agggccattt ctgagcagtg gaggtttcaa gtaatccact    180

 aacaaccagt tccaaattct gtcatcaaat cctgtgctgc tgttcctcgt ggtaatagat    240

 gcatattatt tcttttattt aaaagaa    atg aat gtg act agt att gca tta     291
                                  Met Asn Val Thr Ser Ile Ala Leu
                                    1               5

 aga gct gaa act tgg ctt tta gct gca tgg cat gtt aaa gta cct ccg      339
 Arg Ala Glu Thr Trp Leu Leu Ala Ala Trp His Val Lys Val Pro Pro
      10                  15                  20

 atg tgg ctg gaa gct tgt att aac tgg att caa gaa gaa aat aat aat      387
 Met Trp Leu Glu Ala Cys Ile Asn Trp Ile Gln Glu Glu Asn Asn Asn
  25                  30                  35                  40

 gtt aac ttg agt cag gcc caa atg aat aaa caa gtg ttt gag cag tgg      435
 Val Asn Leu Ser Gln Ala Gln Met Asn Lys Gln Val Phe Glu Gln Trp
                  45                  50                  55

 ctc ctt act gat ctg agg gat ttg gag cat cct ctt tta ccc gat ggc      483
 Leu Leu Thr Asp Leu Arg Asp Leu Glu His Pro Leu Leu Pro Asp Gly
              60                  65                  70

 att tta gaa att cca aaa gga gaa tta aat gga ttt tat gct ctg cag      531
 Ile Leu Glu Ile Pro Lys Gly Glu Leu Asn Gly Phe Tyr Ala Leu Gln
          75                  80                  85

 att aat tcc ttg gtt gat gta agt cag cct gca tac tcc cag ata cag      579
 Ile Asn Ser Leu Val Asp Val Ser Gln Pro Ala Tyr Ser Gln Ile Gln
      90                  95                 100

 aag ttg aga gga aag aat aca aca aat gat cta gtt aca gct gaa gca      627
 Lys Leu Arg Gly Lys Asn Thr Thr Asn Asp Leu Val Thr Ala Glu Ala
 105                 110                 115                 120

 caa gta acc cca aaa cct tgg gaa gca aag cct tca cga atg ttg atg      675
 Gln Val Thr Pro Lys Pro Trp Glu Ala Lys Pro Ser Arg Met Leu Met
                 125                 130                 135

 ctg cag cta act gat gga atc gta caa ata cag gga atg gaa tat cag      723
 Leu Gln Leu Thr Asp Gly Ile Val Gln Ile Gln Gly Met Glu Tyr Gln
             140                 145                 150

 cct att cca att ctt cat agt gat ctt cct cca ggt aca aaa att ttg      771
 Pro Ile Pro Ile Leu His Ser Asp Leu Pro Pro Gly Thr Lys Ile Leu
         155                 160                 165

 att tat gga aat ata tct ttc cgt ctt ggt gtt ctc tta ttg aaa cca      819
 Ile Tyr Gly Asn Ile Ser Phe Arg Leu Gly Val Leu Leu Leu Lys Pro
     170                 175                 180

 gaa aac gtg aaa gtg tta gga ggt gaa gta gat gct ctt tta gaa gaa      867
 Glu Asn Val Lys Val Leu Gly Gly Glu Val Asp Ala Leu Leu Glu Glu
 185                 190                 195                 200

 tat gcc caa gaa aaa gta ctt gca aga tta ata ggg gaa cct gat ctt      915
 Tyr Ala Gln Glu Lys Val Leu Ala Arg Leu Ile Gly Glu Pro Asp Leu
                 205                 210                 215

 gta gtt tca gtc ata cca aac aat tct aac gaa aac att ccc aga gtt      963
 Val Val Ser Val Ile Pro Asn Asn Ser Asn Glu Asn Ile Pro Arg Val
             220                 225                 230

 aca gat gtt cta gat cct gca tta ggt cct tct gat gaa gaa ctc ttg     1011
 Thr Asp Val Leu Asp Pro Ala Leu Gly Pro Ser Asp Glu Glu Leu Leu
         235                 240                 245

 gca agt ctt gat gaa aat gat gag ctt aca gca aat aat gac act tcc     1059
 Ala Ser Leu Asp Glu Asn Asp Glu Leu Thr Ala Asn Asn Asp Thr Ser
     250                 255                 260

 tca gaa cga tgt ttc acc aca ggt agt tcc tca aat acc att ccc aca     1107
 Ser Glu Arg Cys Phe Thr Thr Gly Ser Ser Ser Asn Thr Ile Pro Thr
 265                 270                 275                 280

 aga cag tca agt ttt gag cca gaa ttt gtt att tct cca aga cca aaa     1155
 Arg Gln Ser Ser Phe Glu Pro Glu Phe Val Ile Ser Pro Arg Pro Lys
                 285                 290                 295

 gag gaa cca tca aac cta tct ata cat gta atg gat gga gaa tta gat     1203
 Glu Glu Pro Ser Asn Leu Ser Ile His Val Met Asp Gly Glu Leu Asp
             300                 305                 310

 gac ttt tca ctg gag gag gcc ttg ctt tta gaa gaa act gtc cag aaa     1251
 Asp Phe Ser Leu Glu Glu Ala Leu Leu Leu Glu Glu Thr Val Gln Lys
         315                 320                 325

 gaa cag atg gaa act aag gaa ttg caa cca ttg act ttt aac aga aat     1299
 Glu Gln Met Glu Thr Lys Glu Leu Gln Pro Leu Thr Phe Asn Arg Asn
     330                 335                 340

 gcc gat cga agt ata gag aga ttt tca cat aat cct aat act acg aat     1347
 Ala Asp Arg Ser Ile Glu Arg Phe Ser His Asn Pro Asn Thr Thr Asn
 345                 350                 355                 360

 aac ttt tct ttg act tgc aaa aat gga aac aat aat tgg agt gaa aaa     1395
 Asn Phe Ser Leu Thr Cys Lys Asn Gly Asn Asn Asn Trp Ser Glu Lys
                 365                 370                 375

 aat gta tct gaa caa atg act aat gaa gac aaa tca ttt ggt tgt cca     1443
 Asn Val Ser Glu Gln Met Thr Asn Glu Asp Lys Ser Phe Gly Cys Pro
             380                 385                 390

 tct gtt aga gac caa aac agg agt att ttt tca gtt cat tgt aat gta     1491
 Ser Val Arg Asp Gln Asn Arg Ser Ile Phe Ser Val His Cys Asn Val
         395                 400                 405

 ccc tta gcc cat gat ttt aca aat aaa gaa aag aac tta gag aca gat     1539
 Pro Leu Ala His Asp Phe Thr Asn Lys Glu Lys Asn Leu Glu Thr Asp
     410                 415                 420

 aat aaa ata aaa caa acc agc agt tca gat agc cat tcc tta aat aat     1587
 Asn Lys Ile Lys Gln Thr Ser Ser Ser Asp Ser His Ser Leu Asn Asn
 425                 430                 435                 440

 aaa ata tta aat aga gag gtg gtc aac tat gta cag aaa agg agt tca     1635
 Lys Ile Leu Asn Arg Glu Val Val Asn Tyr Val Gln Lys Arg Ser Ser
                 445                 450                 455

 caa att tct aat gaa aat gat tgt aat tta cag agt tgt tct tta aga     1683
 Gln Ile Ser Asn Glu Asn Asp Cys Asn Leu Gln Ser Cys Ser Leu Arg
             460                 465                 470

 tca tca gag aat agc att aat ctt tct att gcc atg gat ttg tat tct     1731
 Ser Ser Glu Asn Ser Ile Asn Leu Ser Ile Ala Met Asp Leu Tyr Ser
         475                 480                 485

 cca ccc ttt gtc tat ttg tct gtt cta atg gcc agc aaa cca aag gaa     1779
 Pro Pro Phe Val Tyr Leu Ser Val Leu Met Ala Ser Lys Pro Lys Glu
     490                 495                 500

 gtt aca aca gtg aaa gtg aaa gca ttt att gta acc tta act gga aat     1827
 Val Thr Thr Val Lys Val Lys Ala Phe Ile Val Thr Leu Thr Gly Asn
 505                 510                 515                 520

 ctc tca agt tct ggt ggt att tgg agt ata act gca aag gtg tct gat     1875
 Leu Ser Ser Ser Gly Gly Ile Trp Ser Ile Thr Ala Lys Val Ser Asp
                 525                 530                 535

 ggt act gca tat cta gat gta gac ttt gtg gat gaa ata ctt act agc     1923
 Gly Thr Ala Tyr Leu Asp Val Asp Phe Val Asp Glu Ile Leu Thr Ser
             540                 545                 550

 ttg ata ggg ttc tca gta cca gaa atg aaa cag tca aaa aag gat cct     1971
 Leu Ile Gly Phe Ser Val Pro Glu Met Lys Gln Ser Lys Lys Asp Pro
         555                 560                 565

 ctt caa tac caa aag ttc ctg gaa ggg ttg cag aaa tgt caa aga gat     2019
 Leu Gln Tyr Gln Lys Phe Leu Glu Gly Leu Gln Lys Cys Gln Arg Asp
     570                 575                 580

 cta ata gat ttg tgc tgt cta atg act att tca ttt aat cct tcc ttg     2067
 Leu Ile Asp Leu Cys Cys Leu Met Thr Ile Ser Phe Asn Pro Ser Leu
 585                 590                 595                 600

 tct aaa gca atg gta ctg gca tta caa gat gtt aat atg gaa cac ctt     2115
 Ser Lys Ala Met Val Leu Ala Leu Gln Asp Val Asn Met Glu His Leu
                 605                 610                 615

 gag aat cta aag aag cgg tta aat aaa taa t taaactaaaa tagtattagg     2166
 Glu Asn Leu Lys Lys Arg Leu Asn Lys 
             620                 625

 aacaattaaa aacaacaagg aaatatttag aatttgttca caattttact tatgatactt   2226

 tgtgtaaaaa ggaaaaatga aatttcatag cttatttcag tttaatttta aagtgtttaa   2286

 tcatgttgtt atatgtggag cttttgaaaa taagttaatc                         2326




      <210> 427
      <211> 446
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(395)

      <400> 427
 tttcgtccga ggtctcggcc accgggaga  atg acg agc cca ctg gag aag gac      53
                                  Met Thr Ser Pro Leu Glu Lys Asp
                                    1               5

 cct gag ccc aat ggg gca ctg agc cct ggg cct ggg gat acc aat agc      101
 Pro Glu Pro Asn Gly Ala Leu Ser Pro Gly Pro Gly Asp Thr Asn Ser
      10                  15                  20

 tgg ggc ttt ggg agg gat cca gcc ccc agt cct cga gac tca ctg gcc      149
 Trp Gly Phe Gly Arg Asp Pro Ala Pro Ser Pro Arg Asp Ser Leu Ala
  25                  30                  35                  40

 ccg gaa gac tta gag atg ttt gtg ctg gac ttt gag gat ggt gac ctg      197
 Pro Glu Asp Leu Glu Met Phe Val Leu Asp Phe Glu Asp Gly Asp Leu
                  45                  50                  55

 tgg gag tcc atc agg ggc cag ctg ggc ccc atg gca ggg cca cca act      245
 Trp Glu Ser Ile Arg Gly Gln Leu Gly Pro Met Ala Gly Pro Pro Thr
              60                  65                  70

 tgt cac cga ctg gag gac aac cct ggt gtg cgg cga cac tta gtg aaa      293
 Cys His Arg Leu Glu Asp Asn Pro Gly Val Arg Arg His Leu Val Lys
          75                  80                  85

 aag ccc tcc cgg acg cag ggc ggg agg ggc act ccc agc tgg cct ggc      341
 Lys Pro Ser Arg Thr Gln Gly Gly Arg Gly Thr Pro Ser Trp Pro Gly
      90                  95                 100

 ccc cat cct tcg cag gaa gaa gaa gaa gaa aaa gct gga ccg gag gcc      389
 Pro His Pro Ser Gln Glu Glu Glu Glu Glu Lys Ala Gly Pro Glu Ala
 105                 110                 115                 120

 tca tga ggtgttcgtg gagctgaacg agctgatgct ggaccgcagc caggagcccc       445
 Ser 


 a                                                                    446




      <210> 428
      <211> 482
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (339)..(482)

      <400> 428
 aattactagc tccgtgcctt tatgcagctc acttaactcc tctgtctctc agtttctgat     60

 gcgtaaaaca agatgacaat taaaggcacc tattgcctag ggccattagg tggattcaca    120

 tcagtctgtg cactggcagg aggagagttt tatgaatgga ctgtctataa aatgtaggtg    180

 gggaccgtcc atttctccaa cagctgggaa ggatgttggt gttgaagttt acacacctat    240

 caaggacagt aactaccatg gcttctggtg ctttgacaaa acctccaatg catagccttc    300

 tggttaagcg tctgtgattt catattattg gagcattc    atg gta tcc ctg gtg     353
                                              Met Val Ser Leu Val
                                                1               5

 gtt gca gct ttc tac aag att gct atg gac gaa cca aga aag aag gca      401
 Val Ala Ala Phe Tyr Lys Ile Ala Met Asp Glu Pro Arg Lys Lys Ala
                  10                  15                  20

 tac gca gat ttc tac aga aat tat gat tcc ata aaa gat ttt gag atg      449
 Tyr Ala Asp Phe Tyr Arg Asn Tyr Asp Ser Ile Lys Asp Phe Glu Met
              25                  30                  35

 agg aag gct ggt atc ttt cag agt aca aag tga                          482
 Arg Lys Ala Gly Ile Phe Gln Ser Thr Lys 
          40                  45





      <210> 429
      <211> 864
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (265)..(477)

      <400> 429
 ttgggtttcg cggcgctcgc cgcactggtt gttcagcacc ttcggtccgg ttgaggttgt     60

 caagtcggac caaacaggtt gtttctctgc agtttccaac atggcaggga ggtttaatag    120

 acatggataa gaagtccact cacagaaatc ctgaagatgc cagggctggc aaatatgaag    180

 gtaaacacaa acgaaagaaa agaagaaagc aaaaccaaaa ccagcaccga tcccgacata    240

 gatcagtgac gtctttttct tcag   atg atc cta tgt ttc ctt ctt cct cat     291
                              Met Ile Leu Cys Phe Leu Leu Pro His
                                1               5

 cat cgt ctt cag gaa gcc aga cag att caa gta ttg aag atg ctg cca      339
 His Arg Leu Gln Glu Ala Arg Gln Ile Gln Val Leu Lys Met Leu Pro
  10                  15                  20                  25

 agg gaa aaa tta aga aga aga gaa gag aga aaa caa ata aat ggg aaa      387
 Arg Glu Lys Leu Arg Arg Arg Glu Glu Arg Lys Gln Ile Asn Gly Lys
                  30                  35                  40

 aaa gaa agg aca aaa tat gaa aca cca aga aaa aga gaa gga aaa aaa      435
 Lys Glu Arg Thr Lys Tyr Glu Thr Pro Arg Lys Arg Glu Gly Lys Lys
              45                  50                  55

 gga gga aac aac cac ata tgt cac ctt tcc aag agg gac tga aactggg      484
 Gly Gly Asn Asn His Ile Cys His Leu Ser Lys Arg Asp 
          60                  65                  70

 ctgacccttt tgatttccaa actcagcgtt ttggtgtaag gcggccaaag aaggatgcgg    544

 agcccagcac tgtgaagcct acaaaaacat tgatgcgctg gcttggggat ttgaatttga    604

 acatctttca cactaagttc agactcatga aaccaatctt cagatgctct gtaaaccaca    664

 taataaagag tttggaaatt atattttgtt tttgaaggcc cacgtgcaaa acttgagagc    724

 ctcaagtcca agccagttgt ggcaattcta gcctactttt tttttatatt caagtgtgtt    784

 gtagggaagg aggagaataa gtctgctttc ttgaatatta tgcctaatta attacgtata    844

 aaatactttt accaaagttg                                                864




      <210> 430
      <211> 1965
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (83)..(1726)

      <400> 430
 gtccgactac agccacctgt cctccacgag cattctatac cttcgtaaac acttcctaat     60

 ctcctcagca tttgagggca tc atg agc aag agg atg tgt tct gcc ttt acc     112
                          Met Ser Lys Arg Met Cys Ser Ala Phe Thr
                            1               5                  10

 ctt caa gac cca gtt cat ttg gtg cct cct cca gga agc ctt ctg cag      160
 Leu Gln Asp Pro Val His Leu Val Pro Pro Pro Gly Ser Leu Leu Gln
                  15                  20                  25

 agc cct cct tct ttt gtc ata tgt agt gag ctt tcc gtt gaa gag gcg      208
 Ser Pro Pro Ser Phe Val Ile Cys Ser Glu Leu Ser Val Glu Glu Ala
              30                  35                  40

 cag gac cct ttc ctg gtc agc atc cac ata atc gca gac cca ggg gag      256
 Gln Asp Pro Phe Leu Val Ser Ile His Ile Ile Ala Asp Pro Gly Glu
          45                  50                  55

 tcc cag ccc ctg cag gag gcc atc gac aac gtc ctg gcg tgg atc cac      304
 Ser Gln Pro Leu Gln Glu Ala Ile Asp Asn Val Leu Ala Trp Ile His
      60                  65                  70

 ccc gac ctc ccg ctg ttc cgg gtg tcc gag agg cgg gcg tcc cgg cgg      352
 Pro Asp Leu Pro Leu Phe Arg Val Ser Glu Arg Arg Ala Ser Arg Arg
  75                  80                  85                  90

 cgg cgg aag ccc ccc aag ggc gct cag cca gcg ctg gct gtg gtg ctg      400
 Arg Arg Lys Pro Pro Lys Gly Ala Gln Pro Ala Leu Ala Val Val Leu
                  95                 100                 105

 ttc ctg cag gag gag tac ggc gaa gag cag atc ctg cag ctg cac cgc      448
 Phe Leu Gln Glu Glu Tyr Gly Glu Glu Gln Ile Leu Gln Leu His Arg
             110                 115                 120

 aca ctg cag cag ccg ccc tgg cgc cac cac cac acc gag cag gtg cac      496
 Thr Leu Gln Gln Pro Pro Trp Arg His His His Thr Glu Gln Val His
         125                 130                 135

 ggc cgg ttc ctg ccc tac ctg ccc tgc agc cag gac ttc ttc acg ctg      544
 Gly Arg Phe Leu Pro Tyr Leu Pro Cys Ser Gln Asp Phe Phe Thr Leu
     140                 145                 150

 gcc cct ggg acg ccg ctt tgg gcc atc cgg ccc gtg cac tac ggc aag      592
 Ala Pro Gly Thr Pro Leu Trp Ala Ile Arg Pro Val His Tyr Gly Lys
 155                 160                 165                 170

 gaa atc gtg cgc ttc acc gtc tac tgt cgc tac gac aac tat gct gac      640
 Glu Ile Val Arg Phe Thr Val Tyr Cys Arg Tyr Asp Asn Tyr Ala Asp
                 175                 180                 185

 agc ctc agg ttc tac cag ctg att ctc cgg agg agc ccc agc cag aag      688
 Ser Leu Arg Phe Tyr Gln Leu Ile Leu Arg Arg Ser Pro Ser Gln Lys
             190                 195                 200

 aaa gcg gac ttc tgc atc ttc cct att ttt tcc aac ctg gat gtg gac      736
 Lys Ala Asp Phe Cys Ile Phe Pro Ile Phe Ser Asn Leu Asp Val Asp
         205                 210                 215

 atc cag ttc tcc ctg aaa aga ctg ccc tgt gac cag tgc ccg gtg ccc      784
 Ile Gln Phe Ser Leu Lys Arg Leu Pro Cys Asp Gln Cys Pro Val Pro
     220                 225                 230

 acc gac tcc tcc gtg ctg gag ttc cga gtg agg gac ata ggc gag ctc      832
 Thr Asp Ser Ser Val Leu Glu Phe Arg Val Arg Asp Ile Gly Glu Leu
 235                 240                 245                 250

 gtg cct ctc ctg ccc aac cct tgc agc ccc atc agc gag ggg cgc tgg      880
 Val Pro Leu Leu Pro Asn Pro Cys Ser Pro Ile Ser Glu Gly Arg Trp
                 255                 260                 265

 cag acg gag gac cat gat ggg aac aag atc ctc cta cag gca caa agg      928
 Gln Thr Glu Asp His Asp Gly Asn Lys Ile Leu Leu Gln Ala Gln Arg
             270                 275                 280

 gtg cat aag aag ttt cct aaa cct ggc aga gta cat cat gcc tcc gag      976
 Val His Lys Lys Phe Pro Lys Pro Gly Arg Val His His Ala Ser Glu
         285                 290                 295

 aag aaa cgt cat tcc act cct ttg ccg agc act gct gta cca agc cat     1024
 Lys Lys Arg His Ser Thr Pro Leu Pro Ser Thr Ala Val Pro Ser His
     300                 305                 310

 aca cct ggc agc agc cag cag tcc ccg ctc aac agt cct cac ccg ggg     1072
 Thr Pro Gly Ser Ser Gln Gln Ser Pro Leu Asn Ser Pro His Pro Gly
 315                 320                 325                 330

 ccc atc cgg aca ggc ctg cct cct ggg cac cag cag gaa ttt gcc gga     1120
 Pro Ile Arg Thr Gly Leu Pro Pro Gly His Gln Gln Glu Phe Ala Gly
                 335                 340                 345

 cga gcc aac agc acc ccc aac cct ccc tgg tct ttc cag aga agc aag     1168
 Arg Ala Asn Ser Thr Pro Asn Pro Pro Trp Ser Phe Gln Arg Ser Lys
             350                 355                 360

 tcc ttg ttt tgt ttg ccc acg gga ggc ccc tcc ctg gcc tcc tca gct     1216
 Ser Leu Phe Cys Leu Pro Thr Gly Gly Pro Ser Leu Ala Ser Ser Ala
         365                 370                 375

 gaa cca cag tgg ttt tca aac aca ggt gcc cca ggg cac agg gca tca     1264
 Glu Pro Gln Trp Phe Ser Asn Thr Gly Ala Pro Gly His Arg Ala Ser
     380                 385                 390

 gag tgg agg cat ggc cac ctc ctc tcc atc gat gac cta gag ggg gcc     1312
 Glu Trp Arg His Gly His Leu Leu Ser Ile Asp Asp Leu Glu Gly Ala
 395                 400                 405                 410

 cag gag aca gac gtg gac aca ggc ctg cgg ctg tcc tca tcg gac ctg     1360
 Gln Glu Thr Asp Val Asp Thr Gly Leu Arg Leu Ser Ser Ser Asp Leu
                 415                 420                 425

 tct gtg gtc tct gca tat tct gca ccc agt agg ttc tgc agc aca gtg     1408
 Ser Val Val Ser Ala Tyr Ser Ala Pro Ser Arg Phe Cys Ser Thr Val
             430                 435                 440

 gag aca ccc ctc ccc tcc gaa aga tgc agc agc cac tgg gca gct cac     1456
 Glu Thr Pro Leu Pro Ser Glu Arg Cys Ser Ser His Trp Ala Ala His
         445                 450                 455

 aag gat tcc agg gag gga cca ctg ccc act gtc agc agg gtg acc aca     1504
 Lys Asp Ser Arg Glu Gly Pro Leu Pro Thr Val Ser Arg Val Thr Thr
     460                 465                 470

 gag gcc tcc tgg gct tcc ctc cct ttc ttc acc aaa agg tct tcc agc     1552
 Glu Ala Ser Trp Ala Ser Leu Pro Phe Phe Thr Lys Arg Ser Ser Ser
 475                 480                 485                 490

 tcc tca gcg aca gct cgt gct gct ccc cca gct ccc agc acc tcc acc     1600
 Ser Ser Ala Thr Ala Arg Ala Ala Pro Pro Ala Pro Ser Thr Ser Thr
                 495                 500                 505

 ctc aca gac tcc tcc cca cag ctc cca tgc gat acc ccc aaa gtc aag     1648
 Leu Thr Asp Ser Ser Pro Gln Leu Pro Cys Asp Thr Pro Lys Val Lys
             510                 515                 520

 cag act gat gga gac atg cca cca ccc cca ggg tcg gct ggc ccc ggg     1696
 Gln Thr Asp Gly Asp Met Pro Pro Pro Pro Gly Ser Ala Gly Pro Gly
         525                 530                 535

 gat aac gac atg gag gaa ttc tac atc tga a tgccctctgc tcttgttctc     1747
 Asp Asn Asp Met Glu Glu Phe Tyr Ile 
     540                 545

 gaaacacaca aactcagaga cacagactca ggccccactg cccctctggc cactgagcac   1807

 accacattct tcatgatcca tttcccagga gcccgtagca catttgccta ccacccactc   1867

 ttagctgggg ggtggtatat ctctagagac acagcagaaa aatactggca tttttatgca   1927

 aataaattct caacaaactt gtcataaaaa aaaaaaaa                           1965




      <210> 431
      <211> 853
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (150)..(839)

      <400> 431
 ggcggccctg agagctgact ctgcagctga ggtagagaga caacgatcag gaaccctaag     60

 aagaggcgcc agaggagccg ccttctgcct cagaacggcg tgactcggag aattggagcg    120

 ttattcagta tattaatgtc ttattgata  atg gca gaa cat cca cca cta ctg     173
                                  Met Ala Glu His Pro Pro Leu Leu
                                    1               5

 gat aca act cag atc tta agt agt gat att tct ctt ttg tct gcc cct      221
 Asp Thr Thr Gln Ile Leu Ser Ser Asp Ile Ser Leu Leu Ser Ala Pro
      10                  15                  20

 att gta agt gca gat gga aca caa cag gtt att ctg gta caa gtt aac      269
 Ile Val Ser Ala Asp Gly Thr Gln Gln Val Ile Leu Val Gln Val Asn
  25                  30                  35                  40

 cca gga gaa gca ttt aca ata aga aga gaa gat gga cag ttt cag tgc      317
 Pro Gly Glu Ala Phe Thr Ile Arg Arg Glu Asp Gly Gln Phe Gln Cys
                  45                  50                  55

 att aca ggt cct gct cag gtt cca atg atg tcc cca aat ggt tct gtg      365
 Ile Thr Gly Pro Ala Gln Val Pro Met Met Ser Pro Asn Gly Ser Val
              60                  65                  70

 cct cct atc tat gtg cct cct gga tat gcc cca cag gtt att gaa gac      413
 Pro Pro Ile Tyr Val Pro Pro Gly Tyr Ala Pro Gln Val Ile Glu Asp
          75                  80                  85

 aat ggt gtt cga aga gtt gtc gtg gtc cct cag gca cca gag ttt cac      461
 Asn Gly Val Arg Arg Val Val Val Val Pro Gln Ala Pro Glu Phe His
      90                  95                 100

 cct ggt agt cac aca gtt ctc cac cgt tct cca cat cct cct cta cct      509
 Pro Gly Ser His Thr Val Leu His Arg Ser Pro His Pro Pro Leu Pro
 105                 110                 115                 120

 ggt ttc att cct gtc cca act atg atg ccg cct cca cca cgt cat atg      557
 Gly Phe Ile Pro Val Pro Thr Met Met Pro Pro Pro Pro Arg His Met
                 125                 130                 135

 tac tca ccc gtg act gga gct gga gac atg aca aca cag tat atg cca      605
 Tyr Ser Pro Val Thr Gly Ala Gly Asp Met Thr Thr Gln Tyr Met Pro
             140                 145                 150

 cag tat cag tct tca caa gtc tat gga gat gta gat gct cac tct aca      653
 Gln Tyr Gln Ser Ser Gln Val Tyr Gly Asp Val Asp Ala His Ser Thr
         155                 160                 165

 cat gga agg tcc aac ttt aga gat gaa cga tct agt aaa aca tat gaa      701
 His Gly Arg Ser Asn Phe Arg Asp Glu Arg Ser Ser Lys Thr Tyr Glu
     170                 175                 180

 cgt ttg cag aaa aaa ttg aag gat cgc caa gga aca cag aaa gat aaa      749
 Arg Leu Gln Lys Lys Leu Lys Asp Arg Gln Gly Thr Gln Lys Asp Lys
 185                 190                 195                 200

 atg agc agt cca cca tca tca ccc cag aaa tgc cct tct ccc att aat      797
 Met Ser Ser Pro Pro Ser Ser Pro Gln Lys Cys Pro Ser Pro Ile Asn
                 205                 210                 215

 gaa cat aat gga ctt ata aaa gga caa att gct ggt gga taa acacagg      846
 Glu His Asn Gly Leu Ile Lys Gly Gln Ile Ala Gly Gly 
             220                 225

 atcagca                                                              853




      <210> 432
      <211> 568
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (134)..(568)

      <400> 432
 tttcgtgcgc ctggcactga tcctgccggt cgcccactgt cgccgccgcc gccgcccgcg     60

 ggcaccatga cagctctgag cgctggggtt acagactgtg gttttgtgct tgctcaccaa    120

 agctaacctc agc   atg ctc aaa agg aag cag agt tcc agg gtg gaa gcc     169
                  Met Leu Lys Arg Lys Gln Ser Ser Arg Val Glu Ala
                    1               5                  10

 cag cca gtc act gac ttt ggt cct gat gag tct ctg tcg gat aat gct      217
 Gln Pro Val Thr Asp Phe Gly Pro Asp Glu Ser Leu Ser Asp Asn Ala
          15                  20                  25

 gac atc ctc tgg att aac aaa cca tgg gtt cac tct ttg ctg cgc atc      265
 Asp Ile Leu Trp Ile Asn Lys Pro Trp Val His Ser Leu Leu Arg Ile
      30                  35                  40

 tgt gcc atc atc agc gtc att tct gtt tgt atg aat acg cca atg acc      313
 Cys Ala Ile Ile Ser Val Ile Ser Val Cys Met Asn Thr Pro Met Thr
  45                  50                  55                  60

 ttc gag cac tat cct cca ctt cag tat gtg acc ttc act ttg gat aca      361
 Phe Glu His Tyr Pro Pro Leu Gln Tyr Val Thr Phe Thr Leu Asp Thr
                  65                  70                  75

 tta ttg atg ttt ctc tac acg gca gag atg ata gca aaa atg cac atc      409
 Leu Leu Met Phe Leu Tyr Thr Ala Glu Met Ile Ala Lys Met His Ile
              80                  85                  90

 cgg ggc att gtc aag gtg ttt gaa att gct gat ata gtt gat cag atg      457
 Arg Gly Ile Val Lys Val Phe Glu Ile Ala Asp Ile Val Asp Gln Met
          95                 100                 105

 tca cct tgg ggc atg ttg cgg att cca cgg cca ctg att atg atc cga      505
 Ser Pro Trp Gly Met Leu Arg Ile Pro Arg Pro Leu Ile Met Ile Arg
     110                 115                 120

 gca ttc cgg att tat ttc cga ttt gaa ctg cca agg acc aga att aca      553
 Ala Phe Arg Ile Tyr Phe Arg Phe Glu Leu Pro Arg Thr Arg Ile Thr
 125                 130                 135                 140

 aat att tta aag tga                                                  568
 Asn Ile Leu Lys 






      <210> 433
      <211> 1328
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (710)..(1243)

      <400> 433
 tttcgtccca caaacacttc ttgactgctc actatgggta agacactgtg ttaggcactg     60

 ctggaaatat tatgaatatt atgatttaga gatgttgtca gaaagtaaat tctaacataa    120

 cacagaaaac acctttgaaa gataatatct accaactgag atttaaaaat tataatttat    180

 tggtatcaaa atcaaggcta tttgttggaa aggaaatatc attttgaatt actctagaat    240

 aagaaagggc tattttttca tttcctcaag ttttatggga gagtagaaaa aaattaagtg    300

 ttgagcctaa agatcctaaa ttttagggaa tggaacacta catcctgaga tgctcacttt    360

 tccacagaga attccagaaa accaagagag gaaaataagg gaacaactca cagctgtaac    420

 tcatagctgt accgaagaaa cagtaggcat aagacctact ggttgtgaat tcttgctgtt    480

 tagttacaca tattaagtac tcatagactt attaaataat gccaaagttc taaatattca    540

 acgcattata acactgtttt cctcccaata aatttaggcc ctgtacatac aataacttac    600

 tacattttgt acctgtaggg tattataatc tctcgtgaag gggaccatca actcccaaag    660

 tgatgaaaaa accacaagtg ctgtaaattc aagcttgtaa tttgtggcc    atg tgc     715
                                                          Met Cys
                                                            1

 tca aac agc atc gtt aaa cca tgg gct gct agg tgc tta cgc tgg tat      763
 Ser Asn Ser Ile Val Lys Pro Trp Ala Ala Arg Cys Leu Arg Trp Tyr
           5                  10                  15

 tcc tcg gac ccc tca ata gac aca ggt cgg gtc atg gaa agg gat aca      811
 Ser Ser Asp Pro Ser Ile Asp Thr Gly Arg Val Met Glu Arg Asp Thr
      20                  25                  30

 tcc att acc acc act gtc ggc atg atg aaa atg atc cca gtg ttc cca      859
 Ser Ile Thr Thr Thr Val Gly Met Met Lys Met Ile Pro Val Phe Pro
  35                  40                  45                  50

 atc aga atg caa aca gac agc tat aaa cga aga aat gct gct ctt tgg      907
 Ile Arg Met Gln Thr Asp Ser Tyr Lys Arg Arg Asn Ala Ala Leu Trp
                  55                  60                  65

 ctt tcc cgt cag cct ccg gga gtc cct ccc cag ttc tca gat ata att      955
 Leu Ser Arg Gln Pro Pro Gly Val Pro Pro Gln Phe Ser Asp Ile Ile
              70                  75                  80

 tca tct cta aaa gtc cag act gaa aat cac atc tgg gag atg tat ttt     1003
 Ser Ser Leu Lys Val Gln Thr Glu Asn His Ile Trp Glu Met Tyr Phe
          85                  90                  95

 tac ctt aaa aat cag tca aga aaa tgt ggg atc tgg aag tct ctc ttg     1051
 Tyr Leu Lys Asn Gln Ser Arg Lys Cys Gly Ile Trp Lys Ser Leu Leu
     100                 105                 110

 gaa aga ggg ggc aga ggg gag ctg agc aga ggg cga aat cgt gca gtt     1099
 Glu Arg Gly Gly Arg Gly Glu Leu Ser Arg Gly Arg Asn Arg Ala Val
 115                 120                 125                 130

 tac gcg gag ctg ggg acc ccg agc ctc aga gcg agg gga ggc cgg gag     1147
 Tyr Ala Glu Leu Gly Thr Pro Ser Leu Arg Ala Arg Gly Gly Arg Glu
                 135                 140                 145

 cag cgc ccc gga act ggc gcc tca cag aca gcg cgg ggc ggc cgc cac     1195
 Gln Arg Pro Gly Thr Gly Ala Ser Gln Thr Ala Arg Gly Gly Arg His
             150                 155                 160

 ggt ggc ggg aag gcc aag cgc tgg ccc tgg gtt gtt ctt cac cca taa     1243
 Gly Gly Gly Lys Ala Lys Arg Trp Pro Trp Val Val Leu His Pro 
         165                 170                 175

 ccccttcacc tgtaacccca acaagcagcg aaaggcagtc ccgggccctc ggcctcccca   1303

 ctcaccccgt gcccatcgca cgaaa                                         1328




      <210> 434
      <211> 1277
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (207)..(563)

      <400> 434
 gattttagag gaaggcgctc ggttacattg gagaactgga gtggtctgga gttccacggt     60

 gtagtggacc agaggccacc tctcctgggc ttctcagtgt ctcgccgggg gggttcggcc    120

 tgagctggat tgacatagcc cttggcggat ttaaacaacc taaacattaa gcagtacagc    180

 tgcctcaaac ctttgggatt ttcaga atg act gac act gcc gaa gct gtt cca     233
                              Met Thr Asp Thr Ala Glu Ala Val Pro
                                1               5

 aag ttt gaa gag atg ttt gct agt aga ttc aca gaa aat gac aag gag      281
 Lys Phe Glu Glu Met Phe Ala Ser Arg Phe Thr Glu Asn Asp Lys Glu
  10                  15                  20                  25

 tat cag gaa tac ctg aaa cgc cct cct gag tct cct cca att gtt gag      329
 Tyr Gln Glu Tyr Leu Lys Arg Pro Pro Glu Ser Pro Pro Ile Val Glu
                  30                  35                  40

 gaa tgg aat agc aga gct ggt ggg aac caa aga aac aga ggc aat cgg      377
 Glu Trp Asn Ser Arg Ala Gly Gly Asn Gln Arg Asn Arg Gly Asn Arg
              45                  50                  55

 ttg caa gac aac aga cag ttc aga ggc agg gac aac aga tgg ggg tgg      425
 Leu Gln Asp Asn Arg Gln Phe Arg Gly Arg Asp Asn Arg Trp Gly Trp
          60                  65                  70

 cca agt gac aat cga tcc aat cag tgg cat gga cga tcc tgg ggt aac      473
 Pro Ser Asp Asn Arg Ser Asn Gln Trp His Gly Arg Ser Trp Gly Asn
      75                  80                  85

 aac tac ccg caa cac aga caa gaa cct tac tat ccc cag caa tat gga      521
 Asn Tyr Pro Gln His Arg Gln Glu Pro Tyr Tyr Pro Gln Gln Tyr Gly
  90                  95                 100                 105

 cat tat ggt tac aac cag cgg cct cct tac ggt tac tac tga tagaaat      570
 His Tyr Gly Tyr Asn Gln Arg Pro Pro Tyr Gly Tyr Tyr 
                 110                 115

 gttggcagct tttagtaaaa gcatttactc tgttaccatg agaaaagttt gggtgtcttc    630

 tgttggtcat agttttacat ctgattttac agaatggatt attgattttt tggaagttga    690

 gactttaaaa aaaatagatc ttacttgcga aatgcgatgg ttgctgggaa tacctgaaac    750

 tgtggattat attgcttgac ttctacctca gaatcttctt tgtttcatga cttaatagtg    810

 ctttaagttt ggtatattat ttgacctcta ggaattcttt gttttacaca gaaataaaaa    870

 ttttaaaata gaaaatgctt ttactttgta aggtaagaga gtatccatat gcttagatgt    930

 gctcgtttct aaaattctag aggttgatat aatcagctca tgaatgcaca gctatgcttt    990

 ttgtgataga ttgtacataa catcagcagt tgaaaggtaa aacaattgct tttttttttt   1050

 ttttttgcct ttgaaaaaga aaaagggcgc ctttgggacc cctttattaa aaaaaggggc   1110

 cccccccccc ttgggttttt ttttaggggg aaacccgcta aaagccttga aaaaagggga   1170

 agaaactttt caaatttggg cttttattcg gggggggggg gaaaaagggc cccccttttt   1230

 ttttacaacc ctctagcttt tttgttaaac acattacggg ggaaaat                 1277




      <210> 435
      <211> 871
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (17)..(475)

      <400> 435
 gctgaagtgg ggcttc    atg tgg ggg ccc tgt tcc ctg tct gtg cag cat      49
                      Met Trp Gly Pro Cys Ser Leu Ser Val Gln His
                        1               5                  10

 ttg tgg ctc tgg cag aca tgg tca gat gtt gaa ggc cag agg ccg gct       97
 Leu Trp Leu Trp Gln Thr Trp Ser Asp Val Glu Gly Gln Arg Pro Ala
              15                  20                  25

 ctg ctc atc tgc aca gct gca gca gga ccc acg cag gga gtt aag ggt      145
 Leu Leu Ile Cys Thr Ala Ala Ala Gly Pro Thr Gln Gly Val Lys Gly
          30                  35                  40

 tat ggc aag ccc ttt gag cca aga agt gtg aaa aac ata cac tct act      193
 Tyr Gly Lys Pro Phe Glu Pro Arg Ser Val Lys Asn Ile His Ser Thr
      45                  50                  55

 cct gct tac cca gat gcc aca atg cac aga caa ctg ctg gct ccg gtg      241
 Pro Ala Tyr Pro Asp Ala Thr Met His Arg Gln Leu Leu Ala Pro Val
  60                  65                  70                  75

 gaa gga agg atg gca gag aca ttg aat cag aaa ctc cat gtt gcc aat      289
 Glu Gly Arg Met Ala Glu Thr Leu Asn Gln Lys Leu His Val Ala Asn
                  80                  85                  90

 gtg ctg gaa gat gac ccc ggc tac cta cct cac gtc tac agc gag gaa      337
 Val Leu Glu Asp Asp Pro Gly Tyr Leu Pro His Val Tyr Ser Glu Glu
              95                 100                 105

 ggg gag tgt gga ggg gcc cca tcc ctc agc tct ctg gcc agc ttg gaa      385
 Gly Glu Cys Gly Gly Ala Pro Ser Leu Ser Ser Leu Ala Ser Leu Glu
         110                 115                 120

 cag gag ttg caa cct gat ttg ctg gac tct ttg ggt tca aaa gcg act      433
 Gln Glu Leu Gln Pro Asp Leu Leu Asp Ser Leu Gly Ser Lys Ala Thr
     125                 130                 135

 ccg ttt gag gaa ata tat tca gag tca ggt gtt cct tcc taa aaaaaaa      482
 Pro Phe Glu Glu Ile Tyr Ser Glu Ser Gly Val Pro Ser 
 140                 145                 150

 agtctatttt ggagaattga aataattcat ggaagggaat cactattcag ggatttttcc    542

 cctttgctct tcttttccct ccttaaaaga aaaattacct tctagtccta ggatgaggac    602

 acactattag tttgaattaa atgctttgat attctcagat cagccatctt gaaccaaagc    662

 aaaaccacaa gttacacttt cttaaaattt gatttgtcat attttctaga gaaacttgaa    722

 tttaattgtg ttattcttag cttccactgg cagcctagct ttgagggtaa atgaaaatat    782

 aacccataga ttacccagcc acttgggaac agcaggtaat actgaagaaa aataaaaata    842

 gattttgaaa acgttaaaaa aaaaaaaaa                                      871




      <210> 436
      <211> 1113
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(1113)

      <400> 436
 agcgtcgaca aaaactccgg agtggtcatc accgtggagc caattgaccg agaatcccct     60

 catgtaaata acagttttta tgtaatcatc attcacgctg ttgatgatgg cttcccaccg    120

 cagactgcta cagggaccct a  atg ctc ttc ctg tct gac atc aat gac aac     171
                          Met Leu Phe Leu Ser Asp Ile Asn Asp Asn
                            1               5                  10

 gtc ccg act ctc cgg cca cgt tcc cgc tac atg gag gtc tgt gag tct      219
 Val Pro Thr Leu Arg Pro Arg Ser Arg Tyr Met Glu Val Cys Glu Ser
                  15                  20                  25

 gct gtg cat gag ccc ctc cac atc gag gca gag gat ccg gac ctg gag      267
 Ala Val His Glu Pro Leu His Ile Glu Ala Glu Asp Pro Asp Leu Glu
              30                  35                  40

 ccg ttc tct gac cca ttt aca ttt gaa ttg gac aat acc tgg gga aat      315
 Pro Phe Ser Asp Pro Phe Thr Phe Glu Leu Asp Asn Thr Trp Gly Asn
          45                  50                  55

 gcg gag gac aca tgg aag ttg ggg aga aat tgg ggt caa tca gtt gaa      363
 Ala Glu Asp Thr Trp Lys Leu Gly Arg Asn Trp Gly Gln Ser Val Glu
      60                  65                  70

 ctt tta acc ttg aga agc ctg cca cgt ggt aat tac ttg gtg cca ctc      411
 Leu Leu Thr Leu Arg Ser Leu Pro Arg Gly Asn Tyr Leu Val Pro Leu
  75                  80                  85                  90

 ttc att gga gac aaa cag gga ctt tcc cag aag caa act gtc cat gta      459
 Phe Ile Gly Asp Lys Gln Gly Leu Ser Gln Lys Gln Thr Val His Val
                  95                 100                 105

 agg atc tgc ccc tgt gcc agt ggg ctc aca tgt gtg gag ctt gca gat      507
 Arg Ile Cys Pro Cys Ala Ser Gly Leu Thr Cys Val Glu Leu Ala Asp
             110                 115                 120

 gca gaa gtg ggg ctt cat gtg ggg gcc ctg ttc cct gtc tgt gca gca      555
 Ala Glu Val Gly Leu His Val Gly Ala Leu Phe Pro Val Cys Ala Ala
         125                 130                 135

 ttt gtg gct ctg gca gtg gct ctg ctt ttt ctg ttg cga tgc tat ttt      603
 Phe Val Ala Leu Ala Val Ala Leu Leu Phe Leu Leu Arg Cys Tyr Phe
     140                 145                 150

 gtg ctt gaa cct aag agg cat gga tgc tct gta tcc aat gat gaa ggc      651
 Val Leu Glu Pro Lys Arg His Gly Cys Ser Val Ser Asn Asp Glu Gly
 155                 160                 165                 170

 cac caa aca ctg gtc atg tat aat gcg gag agc aaa ggc act tca gcc      699
 His Gln Thr Leu Val Met Tyr Asn Ala Glu Ser Lys Gly Thr Ser Ala
                 175                 180                 185

 cag aca tgg tca gat gtt gaa ggc cag agg ccg gct ctg ctc atc tgc      747
 Gln Thr Trp Ser Asp Val Glu Gly Gln Arg Pro Ala Leu Leu Ile Cys
             190                 195                 200

 aca gct gca gca gga ccc acg cag gga gtt aag ggt tat ggc aag ccc      795
 Thr Ala Ala Ala Gly Pro Thr Gln Gly Val Lys Gly Tyr Gly Lys Pro
         205                 210                 215

 ttt gag cca aga agt gtg aaa aac ata cac tct act cct gct tac cca      843
 Phe Glu Pro Arg Ser Val Lys Asn Ile His Ser Thr Pro Ala Tyr Pro
     220                 225                 230

 gat gcc aca atg cac aga caa ctc ctg gct ccg gtg gaa gga agg atg      891
 Asp Ala Thr Met His Arg Gln Leu Leu Ala Pro Val Glu Gly Arg Met
 235                 240                 245                 250

 gca gag aca ttg aat cag aaa ctc cat gtt gcc aat gtg ctg gaa gat      939
 Ala Glu Thr Leu Asn Gln Lys Leu His Val Ala Asn Val Leu Glu Asp
                 255                 260                 265

 gac ccc ggc tac cta cct cac gtc tac agc gag gaa ggg gag tgt gga      987
 Asp Pro Gly Tyr Leu Pro His Val Tyr Ser Glu Glu Gly Glu Cys Gly
             270                 275                 280

 ggg gcc cca tcc ctc agc tct ctg gcc agc ttg gaa cag gag ttg caa     1035
 Gly Ala Pro Ser Leu Ser Ser Leu Ala Ser Leu Glu Gln Glu Leu Gln
         285                 290                 295

 cct gat ttg ctg gac tct ttg ggt tca aaa gcg act ccg ttt gag gaa     1083
 Pro Asp Leu Leu Asp Ser Leu Gly Ser Lys Ala Thr Pro Phe Glu Glu
     300                 305                 310

 ata tat tca gag tca ggt gtt cct tcc taa                             1113
 Ile Tyr Ser Glu Ser Gly Val Pro Ser 
 315                 320





      <210> 437
      <211> 1059
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(1059)

      <400> 437
 agcgtcgaca aaaactccgg agtggtcatc accgtggagc caattgaccg agaatcccct     60

 catgtaaata acagttttta tgtaatcatc attcacgctg ttgatgatgg cttcccaccg    120

 cagactgcta cagggaccct a  atg ctc ttc ctg tct gac atc aat gac aac     171
                          Met Leu Phe Leu Ser Asp Ile Asn Asp Asn
                            1               5                  10

 gtc ccg act ctc cgg cca cgt tcc cgc tac atg gag gtc tgt gag tct      219
 Val Pro Thr Leu Arg Pro Arg Ser Arg Tyr Met Glu Val Cys Glu Ser
                  15                  20                  25

 gct gtg cat gag ccc ctc cac atc gag gca gag gat ccg gac ctg gag      267
 Ala Val His Glu Pro Leu His Ile Glu Ala Glu Asp Pro Asp Leu Glu
              30                  35                  40

 ccg ttc tct gac cca ttt aca ttt gaa ttg gac aat acc tgg gga aat      315
 Pro Phe Ser Asp Pro Phe Thr Phe Glu Leu Asp Asn Thr Trp Gly Asn
          45                  50                  55

 gcg gag gac aca tgg aag ttg ggg aga aat tgg ggt caa tca gtt gaa      363
 Ala Glu Asp Thr Trp Lys Leu Gly Arg Asn Trp Gly Gln Ser Val Glu
      60                  65                  70

 ctt tta acc ttg aga agc ctg cca cgt ggt aat tac ttg gtg cca ctc      411
 Leu Leu Thr Leu Arg Ser Leu Pro Arg Gly Asn Tyr Leu Val Pro Leu
  75                  80                  85                  90

 ttc att gga gac aaa cag gga ctt tcc cag aag caa act gtc cat gta      459
 Phe Ile Gly Asp Lys Gln Gly Leu Ser Gln Lys Gln Thr Val His Val
                  95                 100                 105

 agg atc tgc ccc tgt gcc agt ggg ctc aca tgt gtg gag ctt gca gat      507
 Arg Ile Cys Pro Cys Ala Ser Gly Leu Thr Cys Val Glu Leu Ala Asp
             110                 115                 120

 gca gaa gtg ggg ctt cat gtg ggg gcc ctg ttc cct gtc tgt gca gca      555
 Ala Glu Val Gly Leu His Val Gly Ala Leu Phe Pro Val Cys Ala Ala
         125                 130                 135

 ttt gtg gct ctg gca gtg gct ctg ctt ttt ctg ttg cga tgc tat ttt      603
 Phe Val Ala Leu Ala Val Ala Leu Leu Phe Leu Leu Arg Cys Tyr Phe
     140                 145                 150

 gtg ctt gaa cct aag agg cat gga tgc tct gta tcc aat gat gaa ggc      651
 Val Leu Glu Pro Lys Arg His Gly Cys Ser Val Ser Asn Asp Glu Gly
 155                 160                 165                 170

 cac caa aca ctg gtc atg tat aat gcg gag agc aaa ggc act tca gcc      699
 His Gln Thr Leu Val Met Tyr Asn Ala Glu Ser Lys Gly Thr Ser Ala
                 175                 180                 185

 cag aca tgg tca gat gtt gaa ggc cag agg ccg gct ctg ctc atc tgc      747
 Gln Thr Trp Ser Asp Val Glu Gly Gln Arg Pro Ala Leu Leu Ile Cys
             190                 195                 200

 aca gct gca gca gga ccc acg cag gga gtt aag gct tac cca gat gcc      795
 Thr Ala Ala Ala Gly Pro Thr Gln Gly Val Lys Ala Tyr Pro Asp Ala
         205                 210                 215

 aca atg cac aga caa ctc ctg gct ccg gtg gaa gga agg atg gca gag      843
 Thr Met His Arg Gln Leu Leu Ala Pro Val Glu Gly Arg Met Ala Glu
     220                 225                 230

 aca ttg aat cag aaa ctc cat gtt gcc aat gtg ctg gaa gat gac ccc      891
 Thr Leu Asn Gln Lys Leu His Val Ala Asn Val Leu Glu Asp Asp Pro
 235                 240                 245                 250

 ggc tac cta cct cac gtc tac agc gag gaa ggg gag tgt gga ggg gcc      939
 Gly Tyr Leu Pro His Val Tyr Ser Glu Glu Gly Glu Cys Gly Gly Ala
                 255                 260                 265

 cca tcc ctc agc tct ctg gcc agc ttg gaa cag gag ttg caa cct gat      987
 Pro Ser Leu Ser Ser Leu Ala Ser Leu Glu Gln Glu Leu Gln Pro Asp
             270                 275                 280

 ttg ctg gac tct ttg ggt tca aaa gcg act ccg ttt gag gaa ata tat     1035
 Leu Leu Asp Ser Leu Gly Ser Lys Ala Thr Pro Phe Glu Glu Ile Tyr
         285                 290                 295

 tca gag tca ggt gtt cct tcc taa                                     1059
 Ser Glu Ser Gly Val Pro Ser 
     300                 305





      <210> 438
      <211> 1017
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (710)..(949)

      <400> 438
 acaaaggaac ggaggagaag tggggaattt ttggacctat gtctttggag aaaatgttcc     60

 aggtattttt agccaccccc ctgttgtagg tagacatgcg aggggtaagc cttattcaac    120

 ccctgccaat cgttatctag gaaggacatt ctcacaccca agttcgccgg gaaacttgac    180

 acacagttag tgccacactg agacagcatg gaagcgtata ccattctagc agtttccaac    240

 atagcggcac attctcaagc acgggggcat caatagtaaa atctgccctt caccattgtt    300

 taaatctatg agacgttcaa gccattccaa ggaatcggtg ctctggagct cctccaaatt    360

 cgccatgcac atgatatata acttagatgg gaaaggaaaa ggtagtggaa acctgttgct    420

 ctcacttcgt tgattttgag tggctaggga atgtcgcagt gaccctctac caatgccaag    480

 acagccgtct gtcaccagga caacctggca aggaattgca ccaccccatt cttgctgaac    540

 gatattgcaa acaccaacta atgcagactc caagcaggtt ttgtcataat catccatatt    600

 acttagtgct tcctgtaggg tattataatc tctcgtgaag gggaccatca actcccaaag    660

 tgatgaaaaa accacaagtg ctgtaaattc aagcttgtaa tttgtggcc    atg tgc     715
                                                          Met Cys
                                                            1

 tca aac agc atc gtt aaa cca tgg gct gct agg tgc tta cgc tgg tat      763
 Ser Asn Ser Ile Val Lys Pro Trp Ala Ala Arg Cys Leu Arg Trp Tyr
           5                  10                  15

 tcc tcg gac ccc tca ata gac aca ggt cgg gtc atg gaa agg gat aca      811
 Ser Ser Asp Pro Ser Ile Asp Thr Gly Arg Val Met Glu Arg Asp Thr
      20                  25                  30

 tcc att acc acc act gtc ggc atg atg aaa atg atc cca gtg ttc cca      859
 Ser Ile Thr Thr Thr Val Gly Met Met Lys Met Ile Pro Val Phe Pro
  35                  40                  45                  50

 atc aga atg caa aca gac agc tta aaa atc agt caa gaa aat gtg gga      907
 Ile Arg Met Gln Thr Asp Ser Leu Lys Ile Ser Gln Glu Asn Val Gly
                  55                  60                  65

 tct gga agt ctc tct tgg aaa gag ggg gca gag ggg agc tga gcagagg      956
 Ser Gly Ser Leu Ser Trp Lys Glu Gly Ala Glu Gly Ser 
              70                  75

 gcgaaatcgt gcagtttacg cggagctggg gaccccgagc ctcagagcga ggggaggccg   1016

 g                                                                   1017




      <210> 439
      <211> 907
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(619)

      <400> 439
 catgaagata aaataactgc acaacttact caaaacccag gacaaattca gagagtcaag     60

 g    atg gaa ctt tgg gct ccc cag agg ctg ccc cag aca cga ggg aag     106
      Met Glu Leu Trp Ala Pro Gln Arg Leu Pro Gln Thr Arg Gly Lys
        1               5                  10                  15

 gcc aca gca ccc tca aag gat cca gac cga ggg ttt cgg aga gat gga      154
 Ala Thr Ala Pro Ser Lys Asp Pro Asp Arg Gly Phe Arg Arg Asp Gly
                  20                  25                  30

 cat cat cgg cct gtc cct cac tct tgg cac aat gga gag agg ttt cac      202
 His His Arg Pro Val Pro His Ser Trp His Asn Gly Glu Arg Phe His
              35                  40                  45

 caa tgg caa gac aac cgt ggg agc ccc cag cca cag cag gag ccc agg      250
 Gln Trp Gln Asp Asn Arg Gly Ser Pro Gln Pro Gln Gln Glu Pro Arg
          50                  55                  60

 gca gac cat cag cag cag ccc cat tat gca tcc agg cca ggg gac tgg      298
 Ala Asp His Gln Gln Gln Pro His Tyr Ala Ser Arg Pro Gly Asp Trp
      65                  70                  75

 cat cag cct gtg tct gga gtt gac tat tac gaa ggt ggt tat cgc aat      346
 His Gln Pro Val Ser Gly Val Asp Tyr Tyr Glu Gly Gly Tyr Arg Asn
  80                  85                  90                  95

 cag ttg tat tca agg cca ggt tat gag aat tca tat cag agc tat cag      394
 Gln Leu Tyr Ser Arg Pro Gly Tyr Glu Asn Ser Tyr Gln Ser Tyr Gln
                 100                 105                 110

 tct ccc aca atg agg gag gaa tat gct tat gga agt tat tac tat cat      442
 Ser Pro Thr Met Arg Glu Glu Tyr Ala Tyr Gly Ser Tyr Tyr Tyr His
             115                 120                 125

 gga cac cca cag ttg gct gca gga cag aaa gag tgc caa ggc aac gga      490
 Gly His Pro Gln Leu Ala Ala Gly Gln Lys Glu Cys Gln Gly Asn Gly
         130                 135                 140

 gtc ctt ata tct ggc acg aag att acc gag agc aaa agt acc ttg atg      538
 Val Leu Ile Ser Gly Thr Lys Ile Thr Glu Ser Lys Ser Thr Leu Met
     145                 150                 155

 aac atc att atg aaa acc agc aca gtc cat tgg aac aat agt gag acc      586
 Asn Ile Ile Met Lys Thr Ser Thr Val His Trp Asn Asn Ser Glu Thr
 160                 165                 170                 175

 cac ttc caa tct aac agt aga gaa ccc ttg taa agacagcc tgcttccaac      637
 His Phe Gln Ser Asn Ser Arg Glu Pro Leu 
                 180                 185

 tctggacagg agtggccggg gggaactgtt ccagggggct gttgctgggg gccagaaaat    697

 agccggcatg gtagggaggc caaccttcag caggggggtc tggtccagcc cacagttagg    757

 gcaggccggc acaagagccc cggggggggc cccagtacac ggcgagtcag ggcgaaagcc    817

 cgggcgacgc ccaaaggtac cactcttgta tcgagaggac tgaagagcgc ccccaaggaa    877

 ccctttgaaa gggatcacac ggagcacaag                                     907




      <210> 440
      <211> 683
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (94)..(621)

      <400> 440
 aaccacgccg cttcccagtc tctgtgcgag gcgtgaagcg cggacctttc aacaagggct     60

 ttattaattc tcacgctgcg gccctggaaa gcg atg gag gtg gcg gct aat tgc     114
                                      Met Glu Val Ala Ala Asn Cys
                                        1               5

 tcc cta cgg gtg aag aga cct ctg ttg gat ccc cgc ttc gag ggt tac      162
 Ser Leu Arg Val Lys Arg Pro Leu Leu Asp Pro Arg Phe Glu Gly Tyr
          10                  15                  20

 aag ctc tct ctt gag ccg ctg cct tgt tac cag ctg gag ctt gac gca      210
 Lys Leu Ser Leu Glu Pro Leu Pro Cys Tyr Gln Leu Glu Leu Asp Ala
      25                  30                  35

 gct gtg gca gag gta aaa ctt cga gat gat caa tat aca ctg gaa cac      258
 Ala Val Ala Glu Val Lys Leu Arg Asp Asp Gln Tyr Thr Leu Glu His
  40                  45                  50                  55

 atg cat gct ttt gga atg tat aat tac ctg cac tgt gat tca tgg tat      306
 Met His Ala Phe Gly Met Tyr Asn Tyr Leu His Cys Asp Ser Trp Tyr
                  60                  65                  70

 caa gac agt gtc tac tat att gat acc ctt gga aga att atg aat tta      354
 Gln Asp Ser Val Tyr Tyr Ile Asp Thr Leu Gly Arg Ile Met Asn Leu
              75                  80                  85

 aca gta atg ctg gac act gcc tta gga aaa cca cga gag gtg ttt cga      402
 Thr Val Met Leu Asp Thr Ala Leu Gly Lys Pro Arg Glu Val Phe Arg
          90                  95                 100

 ctt cct aca gat ttg aca gca tgt gac aac cgt ctt tgt gca tct atc      450
 Leu Pro Thr Asp Leu Thr Ala Cys Asp Asn Arg Leu Cys Ala Ser Ile
     105                 110                 115

 cat ttc tca tct tct acc tgg gtt acc ttg tca gat gga act gga aga      498
 His Phe Ser Ser Ser Thr Trp Val Thr Leu Ser Asp Gly Thr Gly Arg
 120                 125                 130                 135

 ttg tat gtc att gga aca ggt gaa cgt gga aat agc gct tct gaa aaa      546
 Leu Tyr Val Ile Gly Thr Gly Glu Arg Gly Asn Ser Ala Ser Glu Lys
                 140                 145                 150

 tgg gag att atg ttt act gaa gaa ctt ggg gat cct ttt att ata att      594
 Trp Glu Ile Met Phe Thr Glu Glu Leu Gly Asp Pro Phe Ile Ile Ile
             155                 160                 165

 cac agt atc tca ctg cct aaa tgc tga agaac attctatagc taccctactt      646
 His Ser Ile Ser Leu Pro Lys Cys 
         170                 175

 cttcgaatag agaaagaggc actggtatga caaggcg                             683




      <210> 441
      <211> 1727
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1316)..(1510)

      <400> 441
 tttcaatagc acttagaaac actttccaga agccaactta gagttgcaga gtatgcgtga     60

 ggacacttac ccttcttgtt acagaaaagt tcagaaactt gcctgacatg aagcagtgag    120

 tgtcagaacc agtattaaaa tccagcaagt aaaagttcag atggctagcc atcaaatctc    180

 tctgttgctc tccaaggtag caggttgaca aatacatttc tcaaatgtgt tttgtggaac    240

 ccatcgctaa ttctgagcac ttgggttagg gaatttacta aggcatggaa ttgtattaag    300

 cgtgaaatga gtatgaagaa tagccttatt gatcttgaaa ctagactact ctgtgataaa    360

 aacttaggct tgggaaatat gttagcttgt ggtgaaaccg aaagagaata tgaagagaga    420

 agttatgaaa agtagttgtg atttatagtg actgttgatt atgcaacttc tgcctgtagc    480

 taggaatggg gatggacagg aaattaccca cttaagtgct cctctagttg ttggagaaga    540

 cagagctttg gttactactg gctggctttc cctcctggca gggcattcaa gatgttctcc    600

 tggctgtggt gaaatctaag tgtgcaggtt ccattgaata ggacagtctt ggaggtaggg    660

 acaaggggga ggggttcctt ttgttttctc ttgcttatct ctgatgcagc aagtcagttg    720

 actaggtgga atcaggtcta ggttcaaatt ccagctcttt ttaatgctaa ttatgaaact    780

 ttacacagac tgccttttca acctcagttt ccctgaaggt aaaatgggga ggactgtgtc    840

 caggttgtag ggttattatg agcattgaac acagtatcaa tgtaaatgtc aggtccatgt    900

 taaaaactca gtaattgtta ggtttttttc ttttttttca ccttctgtat caaaagacta    960

 agaacattac tgtatattag aaatgtcaga gaaaggtatg tttaaggtaa tggagaagaa   1020

 aattttaatg accaaggaat taggctgtta acatgcagag tagggcttaa cattgtctca   1080

 ttattaaaaa ataaaagttg atttaaaaca atattgtgtg tgattgtgaa gctggtgtct   1140

 gttgtgtgat cagtggtaaa gcacgtgagt tgctaggcac aggtgttgag atttcgtgtt   1200

 tgatcagact tctcttttaa gtttaagcct ggttgaacac aatctctgtc aggtaccgtg   1260

 gaaatcctta atgtgaacca tttcatgaaa ccctcactat tgtccagcgg gggcg atg    1318
                                                              Met
                                                                1

 cta ttt att aac cac att ttt caa atg aga gaa tgg gag ttt ata ggc     1366
 Leu Phe Ile Asn His Ile Phe Gln Met Arg Glu Trp Glu Phe Ile Gly
               5                  10                  15

 cta aga tca gat gcc atc ccc cag acg cct gcc ttg atg cca gtt tcc     1414
 Leu Arg Ser Asp Ala Ile Pro Gln Thr Pro Ala Leu Met Pro Val Ser
          20                  25                  30

 tgt tgc cac ccc cac ccc ctc ctg ttc cag tct agg cca ggt gcc ctt     1462
 Cys Cys His Pro His Pro Leu Leu Phe Gln Ser Arg Pro Gly Ala Leu
      35                  40                  45

 cat ccg tgt ttc tgt ggc ccc ttg tgt tta ttg cag tca caa tac tga     1510
 His Pro Cys Phe Cys Gly Pro Leu Cys Leu Leu Gln Ser Gln Tyr 
  50                  55                  60

 atctcgtttc ttgtctgtgt cccgtaccat gctggacata aacttcttga gaggaaggac   1570

 tgtcttattt atctttgagt tccctgtgtc agactcaatg cctggcacat ggttgtttga   1630

 gaagagttca tggaacgcat ttaagaaata cattaggatc tatattaaga ttctaattaa   1690

 gaccgagttg agtgtttatc gagttaaaaa aaaaaaa                            1727




      <210> 442
      <211> 2662
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (663)..(2288)

      <400> 442
 tttcgtcttc gcttcgacga tttcgtcccc tctacctgtg ggctaccaat gccctggagg     60

 agctggcctg caagctgtgt ccccatgtgc tgagacacca ccagttcctg caacattcct    120

 ctcctgggag ccccagcctg ggactgcaac tcctggctcc taccctggat cttctagctc    180

 cgccaggcag ccctgttcgg aatgcacaca atgagatcct tgaagagcca catcactgtc    240

 ccctccagaa atacactcgg ctgcagactc cctcctcctt ccccactctg gccaccctga    300

 aagaagaagg acagcgtaag gcctgggcct cctttgaccc taaggccctt ctgcccctcc    360

 cggaggcctc ctacctgccc agctgccaac tcaatcgccg cctggcttgg tcctggctct    420

 gtctgctgcc ctctgccttc tgcccagccc aggttttact tggggttctg gtggcttcat    480

 ctcataaagg ttgtctgcaa cttcgggacc aaagtggttc cctgccctgc ctgctcctgg    540

 ccaagcactc tcaacccctc agtgacccac ggctgatagg ctgcctggtg cgggcagaga    600

 ggtttcagtt gatcgtagag agggacgtga gaagcagctt cccttcctgg aaggagctga    660

 gc   atg cca ggc ttc atc cag aag cag cag gcc aga gtc tat gtc cag     707
      Met Pro Gly Phe Ile Gln Lys Gln Gln Ala Arg Val Tyr Val Gln
        1               5                  10                  15

 ttc ttt ctg gct gat gcc ctg atc ctg cct gtg ccc aga ccc tgc ctt      755
 Phe Phe Leu Ala Asp Ala Leu Ile Leu Pro Val Pro Arg Pro Cys Leu
                  20                  25                  30

 cat tca gca aca ccc tca aca cct cag aca gat ccc acc ggc cca gag      803
 His Ser Ala Thr Pro Ser Thr Pro Gln Thr Asp Pro Thr Gly Pro Glu
              35                  40                  45

 gga ccc cac cta gga cag agc cgg ctc ttc ttg ctc tgc cac aag gag      851
 Gly Pro His Leu Gly Gln Ser Arg Leu Phe Leu Leu Cys His Lys Glu
          50                  55                  60

 gcc ctc atg aag cgt aat ttt tgt gtc ccc cca gga gca agt cca gag      899
 Ala Leu Met Lys Arg Asn Phe Cys Val Pro Pro Gly Ala Ser Pro Glu
      65                  70                  75

 gtg ccc aag ccc gcc ctc agt ttc tat gtg ttg ggg agc tgg ctt ggg      947
 Val Pro Lys Pro Ala Leu Ser Phe Tyr Val Leu Gly Ser Trp Leu Gly
  80                  85                  90                  95

 ggc acc cag agg aag gag ggt act gga tgg ggg ctg ccc gag ccc cag      995
 Gly Thr Gln Arg Lys Glu Gly Thr Gly Trp Gly Leu Pro Glu Pro Gln
                 100                 105                 110

 gga aat gac gac aat gat cag aag gtt cac ctc att ttc ttt ggc tct     1043
 Gly Asn Asp Asp Asn Asp Gln Lys Val His Leu Ile Phe Phe Gly Ser
             115                 120                 125

 tca gtc cgc tgg ttt gag ttc ttg cac ccg gga cag gtg tac cga ctc     1091
 Ser Val Arg Trp Phe Glu Phe Leu His Pro Gly Gln Val Tyr Arg Leu
         130                 135                 140

 gta gct cct ggc ccc gct aca cca atg ttg ttt gaa aag gat ggt tca     1139
 Val Ala Pro Gly Pro Ala Thr Pro Met Leu Phe Glu Lys Asp Gly Ser
     145                 150                 155

 tcc tgc ata tct cgg cgt cct ctg gag ttg gct ggc tgt gca tcc tgc     1187
 Ser Cys Ile Ser Arg Arg Pro Leu Glu Leu Ala Gly Cys Ala Ser Cys
 160                 165                 170                 175

 ctc act gtc cag gac aac tgg act ctg gag ctt gaa agc tcc cag gat     1235
 Leu Thr Val Gln Asp Asn Trp Thr Leu Glu Leu Glu Ser Ser Gln Asp
                 180                 185                 190

 atc caa gat gtg ctg gat gca aac aag tca ttg cct gaa tcc tca ctg     1283
 Ile Gln Asp Val Leu Asp Ala Asn Lys Ser Leu Pro Glu Ser Ser Leu
             195                 200                 205

 acc gac ctg ctc agt gac aat ttc aca gat tcc ttg gtg tct ttc tcc     1331
 Thr Asp Leu Leu Ser Asp Asn Phe Thr Asp Ser Leu Val Ser Phe Ser
         210                 215                 220

 gct gag att ttg tca cgg aca cta tgt gaa ccc ctt gtg gcg tct ctc     1379
 Ala Glu Ile Leu Ser Arg Thr Leu Cys Glu Pro Leu Val Ala Ser Leu
     225                 230                 235

 tgg atg aaa ctg ggg aac acg ggg gcc atg aga agg tgt gtg aag cta     1427
 Trp Met Lys Leu Gly Asn Thr Gly Ala Met Arg Arg Cys Val Lys Leu
 240                 245                 250                 255

 aca gtc gct ctt gag act gct gaa tgt gaa ttc ccc cct cac ctg gat     1475
 Thr Val Ala Leu Glu Thr Ala Glu Cys Glu Phe Pro Pro His Leu Asp
                 260                 265                 270

 gta tat ata gaa gac cca cac ttg cct ccc tca cta gga cta ctt cca     1523
 Val Tyr Ile Glu Asp Pro His Leu Pro Pro Ser Leu Gly Leu Leu Pro
             275                 280                 285

 gga gcc cgg gtc cac ttc agc cag ttg gag aaa agg gtt tcc aga tct     1571
 Gly Ala Arg Val His Phe Ser Gln Leu Glu Lys Arg Val Ser Arg Ser
         290                 295                 300

 cac aat gtt tat tgt tgt ttc cgg tca tcc act tat gtg cag gtc ctg     1619
 His Asn Val Tyr Cys Cys Phe Arg Ser Ser Thr Tyr Val Gln Val Leu
     305                 310                 315

 agt ttt ccc cct gag acc acc atc agc gtt ccc ctg ccc cac atc tac     1667
 Ser Phe Pro Pro Glu Thr Thr Ile Ser Val Pro Leu Pro His Ile Tyr
 320                 325                 330                 335

 ctg gct gaa ctt ctg cag ggt ggt cag tcc cca ttc cag gcc act gcc     1715
 Leu Ala Glu Leu Leu Gln Gly Gly Gln Ser Pro Phe Gln Ala Thr Ala
                 340                 345                 350

 tct tgc cat atc gtc tct gtc ttc agc ctt cag ctc ttc tgg gtg tgt     1763
 Ser Cys His Ile Val Ser Val Phe Ser Leu Gln Leu Phe Trp Val Cys
             355                 360                 365

 gct tat tgt acc agc atc tgc cgg cag gga aag tgc act cgc ctg ggc     1811
 Ala Tyr Cys Thr Ser Ile Cys Arg Gln Gly Lys Cys Thr Arg Leu Gly
         370                 375                 380

 tcc act tgc cct acg cag aca gct ata agc cag gcc atc atc agg ctc     1859
 Ser Thr Cys Pro Thr Gln Thr Ala Ile Ser Gln Ala Ile Ile Arg Leu
     385                 390                 395

 ctg gtg gag gat ggg act gcc gaa gcc gtg gtg acc tgt agg aat cac     1907
 Leu Val Glu Asp Gly Thr Ala Glu Ala Val Val Thr Cys Arg Asn His
 400                 405                 410                 415

 cat gtg gca gca gca cta ggg ctg tgt cct aga gag tgg gcc tcc ctc     1955
 His Val Ala Ala Ala Leu Gly Leu Cys Pro Arg Glu Trp Ala Ser Leu
                 420                 425                 430

 cta gat ttc gtc caa gtg cca ggc aga gtg gtc ttg cag ttt gca ggg     2003
 Leu Asp Phe Val Gln Val Pro Gly Arg Val Val Leu Gln Phe Ala Gly
             435                 440                 445

 cct gga gcc caa ctt gag tct tca gcc agg gtt gac gag ccc atg acc     2051
 Pro Gly Ala Gln Leu Glu Ser Ser Ala Arg Val Asp Glu Pro Met Thr
         450                 455                 460

 atg ttc ctc tgg aca ctt tgt act agc ccc tct gtc ctc cgt cct att     2099
 Met Phe Leu Trp Thr Leu Cys Thr Ser Pro Ser Val Leu Arg Pro Ile
     465                 470                 475

 gtg ctt tct ttt gag ctg gaa agg aaa ccg tcg aag atc gtc cca tta     2147
 Val Leu Ser Phe Glu Leu Glu Arg Lys Pro Ser Lys Ile Val Pro Leu
 480                 485                 490                 495

 gaa cct cct cgg cta cag cga ttc cag tgt gga gag ctc cct ttc ctg     2195
 Glu Pro Pro Arg Leu Gln Arg Phe Gln Cys Gly Glu Leu Pro Phe Leu
                 500                 505                 510

 act cac gtg aac ccc agg ctc cga ttg tcc tgc ctt tct atc cga gag     2243
 Thr His Val Asn Pro Arg Leu Arg Leu Ser Cys Leu Ser Ile Arg Glu
             515                 520                 525

 tca gag tac tcc agc tct ctg ggg atc ctt gct tcc tcc tgt taa ctg     2291
 Ser Glu Tyr Ser Ser Ser Leu Gly Ile Leu Ala Ser Ser Cys 
         530                 535                 540

 aactgcaagg atggcctgag agtccttcct tgctgaaaac ctgaaggcct aggtcctggc   2351

 tcctctccct acttgttctg tgattgaacc aaggactcca gattcacaaa ctgctactcc   2411

 actataattt cccttctttg gtgttctggt gccagcctgc cttggcaaaa ttgtggcaac   2471

 aggaaatcat ggccctatta atatgtcctc tgattgggac aaggcacctg cattcacagg   2531

 cggccctgag cacctgggtt ctgactttgt cgcaggagct gagggaacaa aagacttgct   2591

 cgctgtgggg tgatggtgac aggcctattg acctgcaatg aagccctctg gtgtcattta   2651

 aaaaaaaaaa a                                                        2662




      <210> 443
      <211> 316
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (105)..(269)

      <400> 443
 cggcacgagt aagtcctccc ctgttcttat actcctgggg gttgagaaaa atagcatttc     60

 ctatgctctg aaaattctcc aaaacattct ttctaggctg cagg atg gag att aat     116
                                                  Met Glu Ile Asn
                                                    1

 aat aac aga ata ttt ggc atg gcc ttg tta gcc aat cca aag ccc tct      164
 Asn Asn Arg Ile Phe Gly Met Ala Leu Leu Ala Asn Pro Lys Pro Ser
   5                  10                  15                  20

 ggg ctg aag tgg ggg gtt ttc act tca ggg aca tcc agc ctg ggt acc      212
 Gly Leu Lys Trp Gly Val Phe Thr Ser Gly Thr Ser Ser Leu Gly Thr
                  25                  30                  35

 ttc cat ctc agc atc ccc agg cac aga cag gaa ggt gac atc acc cca      260
 Phe His Leu Ser Ile Pro Arg His Arg Gln Glu Gly Asp Ile Thr Pro
              40                  45                  50

 ttt aca tga tgtctgt ctttgtggcc tgggccactg ggtggcttac ctcagaggcg      316
 Phe Thr 






      <210> 444
      <211> 2520
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (668)..(1033)

      <400> 444
 cactcttcct gcaatcagtg tgaaattcca gcttctttga ttcccactta gcagtatgct     60

 ccaatcacgt tgctggcatg gcattctaca gtttggagct gaggttcaaa gccccctgca    120

 tttctctact ggcaggccct ggtgaaggaa gacactttca gggaagaggc tcttacagtc    180

 tatggtggta gccatcttca catccagtca ccagttgcat ctagggagct gctggctata    240

 aaagggatca tccagtggag ttgtaaacaa gggaaccatc ttgcaagatc taggaagagg    300

 aaggggaggg atgtggactg ggtctgatca cagcccttgg ccctgcttca tactttggag    360

 cttattaaga tcaattttga taaccatgta atttcttaga accatggcag gtagtattgt    420

 gctttaaaaa ccagaggctc ctgaaagtcg tttacaccag gtggattgat accatggctg    480

 tagctgatgc aactaacaag tactggggcc agtgatcaca atccagggtt ggaaacagga    540

 gtgaagccca ccagcctgcc tggttgatgg acagcaggct ctgccttctg gaggcggctt    600

 atatcccaac agcctgaggc agggctctgt ggcccaggcc ggcagtggct gcctctcttg    660

 gttctgc  atg gta cat ttt gcc aac cct gag gac cag ttc ttg ggg ttc     709
          Met Val His Phe Ala Asn Pro Glu Asp Gln Phe Leu Gly Phe
            1               5                  10

 cag gcc tcg gcc ttc ctg ctc cac gtg ctc aag ccc cca cat ggg gct      757
 Gln Ala Ser Ala Phe Leu Leu His Val Leu Lys Pro Pro His Gly Ala
  15                  20                  25                  30

 gcg aca cca tct ggc tcc tca cag gga ggt cca gcc atg ttc tct ggg      805
 Ala Thr Pro Ser Gly Ser Ser Gln Gly Gly Pro Ala Met Phe Ser Gly
                  35                  40                  45

 ctc cca gtg agc ccc ctg ccc tcc agc tac ccc cag aat cca tcc ttc      853
 Leu Pro Val Ser Pro Leu Pro Ser Ser Tyr Pro Gln Asn Pro Ser Phe
              50                  55                  60

 att cct cca cca agc tcc tgt gtg agc tgc agc acc cac acg ggg gaa      901
 Ile Pro Pro Pro Ser Ser Cys Val Ser Cys Ser Thr His Thr Gly Glu
          65                  70                  75

 gcc ctg cac tcc agc agc atc ttc cag cct tgg cac aga act gat ggc      949
 Ala Leu His Ser Ser Ser Ile Phe Gln Pro Trp His Arg Thr Asp Gly
      80                  85                  90

 aaa gga agg gct ggg ttt tca gct tct ggg acc cga gga aga ccc cac      997
 Lys Gly Arg Ala Gly Phe Ser Ala Ser Gly Thr Arg Gly Arg Pro His
  95                 100                 105                 110

 ctc act cct cct tcc cca gta cat cag act ggt tag gagg catcccagaa     1047
 Leu Thr Pro Pro Ser Pro Val His Gln Thr Gly 
                 115                 120

 ggggcagcct catgcccagg tttcagccct aaaggtaatg attgtcttga ctctgccttg   1107

 gcatttcgct cggaatcacg gcagacttgg agtgtttctt caaggcaggc atctgcttat   1167

 gagcaaggtc aaagattttt caaaatattg tgcattaatt cattaaagct actgttaaat   1227

 atttgctgtt tttagattgg cgtccgtgct aattctgcag ttgtagcact gtatatttta   1287

 tctcatttct gtgccaagaa agttcatctt tatgtttttc taatacacaa tcttgatcat   1347

 gtttccaaaa taaagcttca gctccttggt caatagaagt aagggtgtag ccatccaggg   1407

 tctcccggct ctaggcagac cggatcccgc agttcatccc atggttgttg aaatgtacct   1467

 cgatcagtca tctctggtat tcctcactct agccatgagc cattgccatc ttatgggccc   1527

 gatttgggta ctctgaatta tgtcatggag tagacagtta cttctaaatc ccagcaacca   1587

 agttgcgtat ccttccttat agctagtttc tatagagaag tgaaaaagaa atctggcttc   1647

 cttaataaga tagttgagcc tatgacatta aggagcagcg ctgctggcgg aagattctag   1707

 attcactggt ggtttaagag gcccagggat ttagttctta ctggtgcgta agtgttttcc   1767

 catcctaacc ggaaaaccac tcacccaggc ttcccccact tcccctcaaa ttttctcagc   1827

 tctgccgctg gtctccatga acggcaaggg gaaccaccac tcattcactg tcagtgtagg   1887

 taagacagag gatgcccttg caaaaattgg gactgaggac agtagcacac ggaatggtgg   1947

 atcgtacatt tgcacccaga gctactaaac gctcagtgac cccagagacc attaatttcc   2007

 cggagtgaag gggatggggg tagagctaat tggaattttt attatccagg actcatccta   2067

 agaagaatgt tggcctctct tcatccctgg cttagccgtc aggtagaacg cttactcacc   2127

 tgacaccgac ttcttagaga agctagtctt ttttgaatgg aggagcgatg gtaaccccac   2187

 tagggggcgc ccatgatcgg ctcccagtgc acccccttaa gggtaagcag gccacatatc   2247

 tagagtctga tagtctgtgt gtacataagg tctagaagtc tgtggaaacg ccctgaaacc   2307

 tgtagtatta tcttaactac cctcttatgt taaggtttac ataataggat ttttaaacaa   2367

 atgtgtttaa ttttttaaga tctcttgtat taaaattttc ttttggaata agctgtggaa   2427

 attttgttac aacctggttg agatcaacct ctttacaatg acacaaattg tgacatttta   2487

 taaattagat acttcagtga aaaaaaaaaa aaa                                2520




      <210> 445
      <211> 1159
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (113)..(589)

      <400> 445
 ggttgagctc gggttgggtt cctcctgggg caggagggaa aggcgggagc cagggcgtca     60

 gggcctgcgg acgatgtgtg tgtgaaaggg cgcgtcagcc ataagaagcc at    atg     115
                                                              Met
                                                                1

 cgt gcg agc cgg tcc cca ccg tcc ccg cgg cgt tgt cac cat cat cat      163
 Arg Ala Ser Arg Ser Pro Pro Ser Pro Arg Arg Cys His His His His
               5                  10                  15

 gag gcc act gga gca gcc tca ggc gct gct gcc ggg ggg ccg ggc gcg      211
 Glu Ala Thr Gly Ala Ala Ser Gly Ala Ala Ala Gly Gly Pro Gly Ala
          20                  25                  30

 ggg tgc gtc ggg ctc tgc agg ttg gca ctc aca ccc agc gcg cag gat      259
 Gly Cys Val Gly Leu Cys Arg Leu Ala Leu Thr Pro Ser Ala Gln Asp
      35                  40                  45

 ggc agg aat agc aca ttt caa acc tac aag aaa gaa gtg tgc ctc ccc      307
 Gly Arg Asn Ser Thr Phe Gln Thr Tyr Lys Lys Glu Val Cys Leu Pro
  50                  55                  60                  65

 cgt cat tcg atg cac cct ggc ccc tgg gcc atc tgc tgt gaa tgc cag      355
 Arg His Ser Met His Pro Gly Pro Trp Ala Ile Cys Cys Glu Cys Gln
                  70                  75                  80

 acc aga ttc ggg ggc cgc ctg cct gtg tcc agg gtg gaa gca gca ctg      403
 Thr Arg Phe Gly Gly Arg Leu Pro Val Ser Arg Val Glu Ala Ala Leu
              85                  90                  95

 cct tac tgg gtc cct ctg tcc ctg aga ccc cga aag cag cac ccc tgc      451
 Pro Tyr Trp Val Pro Leu Ser Leu Arg Pro Arg Lys Gln His Pro Cys
         100                 105                 110

 tgg atg cat gct gct ggc aca act gct ggc gga tct gcg gtg atg agt      499
 Trp Met His Ala Ala Gly Thr Thr Ala Gly Gly Ser Ala Val Met Ser
     115                 120                 125

 gcc tgt tgt cca agt tcc agc agc tcc agg ccc cct acc agg acc agc      547
 Ala Cys Cys Pro Ser Ser Ser Ser Ser Arg Pro Pro Thr Arg Thr Ser
 130                 135                 140                 145

 tac cgg ctc ctg cag cgc gtc tgc tgc ccc tcg gcc tcc tga ccctcct      596
 Tyr Arg Leu Leu Gln Arg Val Cys Cys Pro Ser Ala Ser 
                 150                 155

 ccaggccatc ccgagggtca tcatggccat tcgccagtgt tttggggttt gaagttggaa    656

 tcttcagcta ctgtcaagaa cagccacaaa aatgtgtcac gatcaagatc tttgagagtc    716

 caccaatcag gaggcgtctg tgacagtcgc tgtcttctca gaacagaatc cacacccagg    776

 attcaaccca aatgatttct catcaggtga ttcttggttg tagcaaagtt catgtgaatg    836

 tgggtgagtt tctgttatga atgtggtcaa taaatgttat ttgtgaaact ctaaactggc    896

 cacctcttaa atgatgacct ctgatttccc ttcattaagg ggggacttgt ccccatgtcc    956

 gtgtccctgg gggagggcag ctatttccga gtgtctcttc agggacagca gacccactgg   1016

 atgagggccc gaaaatggtt tcagcacctg tgtcaggtgg gtctcccttt aagtagcata   1076

 acattgtata tgtgaattga attttaaaat ctgagatctc ttttatatgt cataaaattc   1136

 actcttttag agtaaaaaaa aaa                                           1159




      <210> 446
      <211> 1819
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (486)..(1385)

      <400> 446
 ggactatggg acttatgcct gggagactcc ttccttcaac aactctagtg ctggtggagg     60

 acctgagaga tcatctacag aagttcaatc ccttattttg ttaaaaagag accggatagg    120

 taggggaggg aagagaagtg actcaagttt gacaaatcca aacctgggct cccctctcct    180

 gcgcctcgcc cgctattctt tccactcggc cagcgtgact ccaagacgcg ccactaccct    240

 tctactagcc ggctgcccgg cctctcctcc acttaccctg gccactgggg cgctcctctc    300

 atcagtgtcc caggcccaga agccccgccc acgccaggca taggccccgc ccctgtatcc    360

 caagaccctg cctcctcttg cggtgggggg aaagcggcct cttactctag gcctttcggt    420

 ttgcgcgagc gggcaggaaa gcgtgcgtgc ggctaagaga gtgggcgctc tcgcggccgc    480

 tgacg    atg gaa gaa ctg gag caa ggc ctg ttg atg cag cca tgg gcg     527
          Met Glu Glu Leu Glu Gln Gly Leu Leu Met Gln Pro Trp Ala
            1               5                  10

 tgg cta cag ctt gca gag aac tcc ctc ttg gcc aag gtt ttt atc acc      575
 Trp Leu Gln Leu Ala Glu Asn Ser Leu Leu Ala Lys Val Phe Ile Thr
  15                  20                  25                  30

 aag cag ggc tat gcc ttg ttg gtt tca gat ctt caa cag gtg tgg cat      623
 Lys Gln Gly Tyr Ala Leu Leu Val Ser Asp Leu Gln Gln Val Trp His
                  35                  40                  45

 gaa cag gtg gac act agt gtg gtc agc cag cga gcc aag gag ctg aac      671
 Glu Gln Val Asp Thr Ser Val Val Ser Gln Arg Ala Lys Glu Leu Asn
              50                  55                  60

 aag cgg ctc act gct cct cct gca gct ttc ctc tgt cat ttg gat aat      719
 Lys Arg Leu Thr Ala Pro Pro Ala Ala Phe Leu Cys His Leu Asp Asn
          65                  70                  75

 ctc ctt cgc cca ttg ttg aag gac gct gct cac cct agc gaa gct acc      767
 Leu Leu Arg Pro Leu Leu Lys Asp Ala Ala His Pro Ser Glu Ala Thr
      80                  85                  90

 ttc tcc tgt gat tgt gtg gca gat gca ctg att cta cgg gtg cga agt      815
 Phe Ser Cys Asp Cys Val Ala Asp Ala Leu Ile Leu Arg Val Arg Ser
  95                 100                 105                 110

 gag ctc tct ggc ctc ccc ttc tat tgg aat ttc cac tgc atg cta gct      863
 Glu Leu Ser Gly Leu Pro Phe Tyr Trp Asn Phe His Cys Met Leu Ala
                 115                 120                 125

 agt cct tcc ctg gtc tcc caa cat ttg att cgt cct ctg atg ggc atg      911
 Ser Pro Ser Leu Val Ser Gln His Leu Ile Arg Pro Leu Met Gly Met
             130                 135                 140

 agt ctg gca tta cag tgc caa gtg agg gag cta gca acg tta ctt cat      959
 Ser Leu Ala Leu Gln Cys Gln Val Arg Glu Leu Ala Thr Leu Leu His
         145                 150                 155

 atg aaa gac cta gag atc caa gac tac cag gag agt ggg gct acg ctg     1007
 Met Lys Asp Leu Glu Ile Gln Asp Tyr Gln Glu Ser Gly Ala Thr Leu
     160                 165                 170

 att cga gat cga ttg aag aca gaa cca ttt gaa gaa aat tcc ttc ttg     1055
 Ile Arg Asp Arg Leu Lys Thr Glu Pro Phe Glu Glu Asn Ser Phe Leu
 175                 180                 185                 190

 gaa caa ttt atg ata gag aaa ctg cca gag gca tgc agc att ggt gat     1103
 Glu Gln Phe Met Ile Glu Lys Leu Pro Glu Ala Cys Ser Ile Gly Asp
                 195                 200                 205

 gga aag ccc ttt gtc atg aat ctg cag gat ctg tat atg gca gtc acc     1151
 Gly Lys Pro Phe Val Met Asn Leu Gln Asp Leu Tyr Met Ala Val Thr
             210                 215                 220

 aca caa gag gtc caa gtg gga cag aag cat caa ggc gct gga gat cct     1199
 Thr Gln Glu Val Gln Val Gly Gln Lys His Gln Gly Ala Gly Asp Pro
         225                 230                 235

 cat acc tca aac agt gct tcc ctg caa gga atc gat agc caa tgt gta     1247
 His Thr Ser Asn Ser Ala Ser Leu Gln Gly Ile Asp Ser Gln Cys Val
     240                 245                 250

 aac cag cca gaa caa ctg gtc tcc tca gcc cca acc ctc tca gca cct     1295
 Asn Gln Pro Glu Gln Leu Val Ser Ser Ala Pro Thr Leu Ser Ala Pro
 255                 260                 265                 270

 gag aaa gag tcc acg ggt act tca ggc cct ctg cag aga cct cag ctg     1343
 Glu Lys Glu Ser Thr Gly Thr Ser Gly Pro Leu Gln Arg Pro Gln Leu
                 275                 280                 285

 tca aag gtc aag agg aag aag cca agg ggt ctc ttc agt taa tctgttg     1392
 Ser Lys Val Lys Arg Lys Lys Pro Arg Gly Leu Phe Ser 
             290                 295

 tggcctcagc tgctgaggat ggacttggag aacagcttcc aagcttcacc ttgaaagaag   1452

 cttacatggc agcaatattt ctaaaatagt gatacagtca gaggcctcct gtaagggcga   1512

 gagaactgaa gttgatgttg acaggcccac agggaattgg ccttccctgt tcaagtggaa   1572

 gccagtctct gagaatcccg tgctctcctc tcttttggtg gaggttctgt aggttcaggt   1632

 ttctaccatg gactttaggt atatagggca agtcagcaag aaagcaccac acactcagga   1692

 agccttgtct acctttccct agcgtctcta gccagccagc cccagatact cctcagagac   1752

 ccacttctct cttttgcatg gaataaaaag cactcacagt ccctgctttt gggattaaaa   1812

 aaaaaaa                                                             1819




      <210> 447
      <211> 1765
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (486)..(1331)

      <400> 447
 ggactatggg acttatgcct gggagactcc ttccttcaac aactctagtg ctggtggagg     60

 acctgagaga tcatctacag aagttcaatc ccttattttg ttaaaaagag accggatagg    120

 taggggaggg aagagaagtg actcaagttt gacaaatcca aacctgggct cccctctcct    180

 gcgcctcgcc cgctattctt tccactcggc cagcgtgact ccaagacgcg ccactaccct    240

 tctactagcc ggctgcccgg cctctcctcc acttaccctg gccactgggg cgctcctctc    300

 atcagtgtcc caggcccaga agccccgccc acgccaggca taggccccgc ccctgtatcc    360

 caagaccctg cctcctcttg cggtgggggg aaagcggcct cttactctag gcctttcggt    420

 ttgcgcgagc gggcaggaaa gcgtgcgtgc ggctaagaga gtgggcgctc tcgcggccgc    480

 tgacg    atg gaa gaa ctg gag caa ggc ctg ttg atg cag cca tgg gcg     527
          Met Glu Glu Leu Glu Gln Gly Leu Leu Met Gln Pro Trp Ala
            1               5                  10

 tgg cta cag ctt gca gag aac tcc ctc ttg gcc aag gtt ttt atc acc      575
 Trp Leu Gln Leu Ala Glu Asn Ser Leu Leu Ala Lys Val Phe Ile Thr
  15                  20                  25                  30

 aag cag ggc tat gcc ttg ttg gtt tca gat ctt caa cag gtg tgg cat      623
 Lys Gln Gly Tyr Ala Leu Leu Val Ser Asp Leu Gln Gln Val Trp His
                  35                  40                  45

 gaa cag gtg gac act agt gtg gtc agc cag cga gcc aag gag ctg aac      671
 Glu Gln Val Asp Thr Ser Val Val Ser Gln Arg Ala Lys Glu Leu Asn
              50                  55                  60

 aag cgg ctc act gct cct cct gca gct ttc ctc tgt cat ttg gat aat      719
 Lys Arg Leu Thr Ala Pro Pro Ala Ala Phe Leu Cys His Leu Asp Asn
          65                  70                  75

 ctc ctt cgc cca ttg ttg aag gac gct gct cac cct agc gaa gct acc      767
 Leu Leu Arg Pro Leu Leu Lys Asp Ala Ala His Pro Ser Glu Ala Thr
      80                  85                  90

 ttc tcc tgt gat tgt gtg gca gat gca ctg att cta cgg gtg cga agt      815
 Phe Ser Cys Asp Cys Val Ala Asp Ala Leu Ile Leu Arg Val Arg Ser
  95                 100                 105                 110

 gag ctc tct ggc ctc ccc ttc tat tgg aat ttc cac tgc atg cta gct      863
 Glu Leu Ser Gly Leu Pro Phe Tyr Trp Asn Phe His Cys Met Leu Ala
                 115                 120                 125

 agt cct tcc ctg gtc tcc caa cat ttg att cgt cct ctg atg ggc atg      911
 Ser Pro Ser Leu Val Ser Gln His Leu Ile Arg Pro Leu Met Gly Met
             130                 135                 140

 agt ctg gca tta cag tgc caa gtg agg gag cta gca acg tta ctt cat      959
 Ser Leu Ala Leu Gln Cys Gln Val Arg Glu Leu Ala Thr Leu Leu His
         145                 150                 155

 atg aaa gac cta gag atc caa gac tac cag gag agt ggg gct acg ctg     1007
 Met Lys Asp Leu Glu Ile Gln Asp Tyr Gln Glu Ser Gly Ala Thr Leu
     160                 165                 170

 att cga gat cga ttg aag aca gaa cca ttt gaa gtt ggt gat gga aag     1055
 Ile Arg Asp Arg Leu Lys Thr Glu Pro Phe Glu Val Gly Asp Gly Lys
 175                 180                 185                 190

 ccc ttt gtc atg aat ctg cag gat ctg tat atg gca gtc acc aca caa     1103
 Pro Phe Val Met Asn Leu Gln Asp Leu Tyr Met Ala Val Thr Thr Gln
                 195                 200                 205

 gag gtc caa gtg gga cag aag cat caa ggc gct gga gat cct cat acc     1151
 Glu Val Gln Val Gly Gln Lys His Gln Gly Ala Gly Asp Pro His Thr
             210                 215                 220

 tca aac agt gct tcc ctg caa gga atc gat agc caa tgt gta aac cag     1199
 Ser Asn Ser Ala Ser Leu Gln Gly Ile Asp Ser Gln Cys Val Asn Gln
         225                 230                 235

 cca gaa caa ctg gtc tcc tca gcc cca acc ctc tca gca cct gag aaa     1247
 Pro Glu Gln Leu Val Ser Ser Ala Pro Thr Leu Ser Ala Pro Glu Lys
     240                 245                 250

 gag tcc acg ggt act tca ggc cct ctg cag aga cct cag ctg tca aag     1295
 Glu Ser Thr Gly Thr Ser Gly Pro Leu Gln Arg Pro Gln Leu Ser Lys
 255                 260                 265                 270

 gtc aag agg aag aag cca agg ggt ctc ttc agt taa tctg ttgtggcctc     1345
 Val Lys Arg Lys Lys Pro Arg Gly Leu Phe Ser 
                 275                 280

 agctgctgag gatggacttg gagaacagct tccaagcttc accttgaaag aagcttacat   1405

 ggcagcaata tttctaaaat agtgatacag tcagaggcct cctgtaaggg cgagagaact   1465

 gaagttgatg ttgacaggcc cacagggaat tggccttccc tgttcaagtg gaagccagtc   1525

 tctgagaatc ccgtgctctc ctctcttttg gtggaggttc tgtaggttca ggtttctacc   1585

 atggacttta ggtatatagg gcaagtcagc aagaaagcac cacacactca ggaagccttg   1645

 tctacctttc cctagcgtct ctagccagcc agccccagat actcctcaga gacccacttc   1705

 tctcttttgc atggaataaa aagcactcac agtccctgct tttgggatta aaaaaaaaaa   1765




      <210> 448
      <211> 753
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (290)..(532)

      <400> 448
 tggaatcaag gccagctctt acttggctgc aaaatccatg ttttatgcag ctcctccact     60

 atcttggcct ccaaggcagc tggctttgaa cactaccctt gcagcccagt cagccaatcc    120

 cttgctctcc tgaagctttt gctggtgggc cagccccacc tgctttcctt gtgcactctg    180

 acttggaccc tgaagtgaga agagttggca caggacatct tacttccctg aaaacagtac    240

 ctggactttt ctgtatcttc acatccattg ggcattgggc aaatgggtc    atg cag     295
                                                          Met Gln
                                                            1

 atg aaa acc atc caa gat aag aga cat ggg agt gaa att cac acc cac      343
 Met Lys Thr Ile Gln Asp Lys Arg His Gly Ser Glu Ile His Thr His
           5                  10                  15

 tct ggc ttt cat acc atg ggt ctg aac att agc cca tgg tgt ttc ttg      391
 Ser Gly Phe His Thr Met Gly Leu Asn Ile Ser Pro Trp Cys Phe Leu
      20                  25                  30

 gcc ata ctg acc tgt gcc att tca gct gca ttc atc tca gtt ggt gtt      439
 Ala Ile Leu Thr Cys Ala Ile Ser Ala Ala Phe Ile Ser Val Gly Val
  35                  40                  45                  50

 gtc tgc tgg ctg ctc ttt ctg att tcc cac agg agc agt aag aac ctg      487
 Val Cys Trp Leu Leu Phe Leu Ile Ser His Arg Ser Ser Lys Asn Leu
                  55                  60                  65

 agg aag agt agg gtc aga gga gtc tgg gag aat gag gaa ata tga gag      535
 Arg Lys Ser Arg Val Arg Gly Val Trp Glu Asn Glu Glu Ile 
              70                  75                  80

 ccccaggaac tgaaaaggcc tgtgagagac tctgagcttc ctgggaacag gtataggttc    595

 tttttatttc aataataaca gaaacaactg tcaaaaccat gtgcctgtac tatttggagt    655

 gctgtccttg cagaatctca ttataagaac cttaggaaat aggcacatca tctcctggat    715

 agaatcctag gaaatgggca ctataatggg cactttat                            753




      <210> 449
      <211> 1013
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (627)..(1013)

      <400> 449
 gtgctttact ggaggagggc tggcagcaga aatgcagctg accgggttgc gttttcgtac     60

 ggctgactaa agcggatacc ggtggcgact catttctcgt tttatttttc aacgatttgg    120

 cggagaagct cctcttgtga atggactttg gatttcttgg agctgcgctg cgggtcccac    180

 agtgtggctt tcggcccgtg ctgtgctggc gcctgcactt cctctggcgg ggcacggggt    240

 ggcgctcccg ggtaaagcag cggccagggg gagccgtgag tgaggcgctg cctctcccgc    300

 tgaagcgggt tccaaggcca ccgtgagggg gaccatccat ccaggagagt actgggcagg    360

 ctgcaaatgt ctgtgttaaa acagctctgc tgggctaaga caggacagaa gcagacagca    420

 ggtggatgag acacaatttc ctatccagca gaacctgcag caagctccac agcaccctcc    480

 atgggctcag tcttgctccc gggaagatgg ttaattccat cagctccttc tggccggcag    540

 caggaagagt ggccctgtgt gtgccaggcc ctgcagtctc tcctctcagc tggtgtctcc    600

 agtgagggac ctgagtcatc gcacac atg agc ctg tgc tca gcc tgc aca tct     653
                              Met Ser Leu Cys Ser Ala Cys Thr Ser
                                1               5

 ccc gcc tcc cac cag ctg ctc ctc aac tgc cag ggc cag act gtg gca      701
 Pro Ala Ser His Gln Leu Leu Leu Asn Cys Gln Gly Gln Thr Val Ala
  10                  15                  20                  25

 aaa tct cac tcc tct gcc gat gct ggg gtt tcc ctc gtg tct ggg agg      749
 Lys Ser His Ser Ser Ala Asp Ala Gly Val Ser Leu Val Ser Gly Arg
                  30                  35                  40

 tgg tgt gct tgg tgg cct gag cac tgc agt gaa tcc atg ttt ccc tcc      797
 Trp Cys Ala Trp Trp Pro Glu His Cys Ser Glu Ser Met Phe Pro Ser
              45                  50                  55

 cag cac cct gtt ctg tcc tcc aac ttg gcc gac agc tct ggc cag gga      845
 Gln His Pro Val Leu Ser Ser Asn Leu Ala Asp Ser Ser Gly Gln Gly
          60                  65                  70

 cgc agc cca gct ggt gcc cac ccc gca ctc tgt cca ttt cat aag agc      893
 Arg Ser Pro Ala Gly Ala His Pro Ala Leu Cys Pro Phe His Lys Ser
      75                  80                  85

 cct tgg ttt cct cac ttc cct cag att ttg cca aga gaa tgg tcc tgg      941
 Pro Trp Phe Pro His Phe Pro Gln Ile Leu Pro Arg Glu Trp Ser Trp
  90                  95                 100                 105

 tgt ggc cca gaa agg cca gcg ggg tgc agc ctg gga ctg aaa gca gag      989
 Cys Gly Pro Glu Arg Pro Ala Gly Cys Ser Leu Gly Leu Lys Ala Glu
                 110                 115                 120

 gcg gct ctg gtg ggg aaa aag tag                                     1013
 Ala Ala Leu Val Gly Lys Lys 
             125





      <210> 450
      <211> 468
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (128)..(250)

      <400> 450
 tttcgtgttt gagatgggag gcgcttgcag gggctccccc agttctgcgc tgtgagccgg     60

 ggcacaaaga gccctctgca ctagcgccgc aggaccgcgg acccgagttg gaggcatctg    120

 tccaccc  atg tgg ttc cag aca cgt tca tgt ggc cac cat gac ccc gtc     169
          Met Trp Phe Gln Thr Arg Ser Cys Gly His His Asp Pro Val
            1               5                  10

 ggc atc aca ggg gta acc aag gtg atc ctc cct ctc ttc ctg tgt cca      217
 Gly Ile Thr Gly Val Thr Lys Val Ile Leu Pro Leu Phe Leu Cys Pro
  15                  20                  25                  30

 ctg ggg atg gta gag acc agc tta atg ctt tga gatcagat ccatcacgaa      268
 Leu Gly Met Val Glu Thr Ser Leu Met Leu 
                  35                  40

 atccgtatgt cctgagacct cctgaatctt aaggtgggag agacttctga tgaccctctg    328

 ggttccagtt ccccaatcgt ggctttcccg actgaccttg gcttgaagtg ggtggtctgt    388

 gtggcctagt gaaagctgag atgatgaggc cctggtgctc acaactggtt ctttgtgcgg    448

 cctttgatct ggcacttttt                                                468




      <210> 451
      <211> 757
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (386)..(706)

      <400> 451
 acgcgactct tgggagcggt tattctgctc aaatcctgtc cagggctgac aaggaggaga     60

 atagggggtg gttgccggga ggaccagcac ctccagttac tggagggttg ataggggcct    120

 tctcctttcc gtcacccttt actagggggt atcccttgca gataaatgag attttttgat    180

 ttcttaaaaa gccagctgca gtgaagaagc aactgctgca ggtcgagggg aagagaggca    240

 agtgcacggc tgtctataac gtgctgccgg gtctcaggat ggaggagtga agtctcctgt    300

 cgccgtggtt ccagcctccg gagctcgccc aagccgcgtc cccagagagc gccctgagag    360

 aacagggtgg ccgcttggtc cagga  atg ttt acc ctt gcg gaa gtt gca tca     412
                              Met Phe Thr Leu Ala Glu Val Ala Ser
                                1               5

 ctt aat gac att cag cca act tac cga atc ctg aaa cca tgg tgg gat      460
 Leu Asn Asp Ile Gln Pro Thr Tyr Arg Ile Leu Lys Pro Trp Trp Asp
  10                  15                  20                  25

 gtg ttt atg gat tac cta gct gtt gtt atg tta atg gta gcc atc ttt      508
 Val Phe Met Asp Tyr Leu Ala Val Val Met Leu Met Val Ala Ile Phe
                  30                  35                  40

 gca gga acc atg caa ctt acc aaa gat cag gtg gtc tgt atg cca gta      556
 Ala Gly Thr Met Gln Leu Thr Lys Asp Gln Val Val Cys Met Pro Val
              45                  50                  55

 ttg cca tct cct gta aat tca aag gca cat aca cca cca gga aat gcc      604
 Leu Pro Ser Pro Val Asn Ser Lys Ala His Thr Pro Pro Gly Asn Ala
          60                  65                  70

 gag gtc acc acc aac atc cca cag atg gca gca gac acc aac caa gac      652
 Glu Val Thr Thr Asn Ile Pro Gln Met Ala Ala Asp Thr Asn Gln Asp
      75                  80                  85

 caa gat ggg cgg aca agc aaa cga aca ttt cct ttg ggg aca cat ctg      700
 Gln Asp Gly Arg Thr Ser Lys Arg Thr Phe Pro Leu Gly Thr His Leu
  90                  95                 100                 105

 ctg tga ccaccctgaa ataacctctc agaagcccac atttatctcc gcacagattt       756
 Leu 


 t                                                                    757




      <210> 452
      <211> 1062
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (7)..(378)

      <400> 452
 gcggag   atg gag gat ttg ctc gac ttg gac gag gag ctt cgc tac agc      48
          Met Glu Asp Leu Leu Asp Leu Asp Glu Glu Leu Arg Tyr Ser
            1               5                  10

 ttg gct acc tcc agg gcc aag atg ggt cgc cga gct caa cag gag tca       96
 Leu Ala Thr Ser Arg Ala Lys Met Gly Arg Arg Ala Gln Gln Glu Ser
  15                  20                  25                  30

 gcg cag gcc gag aat cac ctc aat ggc aag aat tcc tct ttg act ctg      144
 Ala Gln Ala Glu Asn His Leu Asn Gly Lys Asn Ser Ser Leu Thr Leu
                  35                  40                  45

 act gga gag act tcc tct gct aaa tta cct cgc tgc cga cag gga ggc      192
 Thr Gly Glu Thr Ser Ser Ala Lys Leu Pro Arg Cys Arg Gln Gly Gly
              50                  55                  60

 tgg gca ggt gat tcc gtg aag gct tcg aag ttt agg agg aag gct tct      240
 Trp Ala Gly Asp Ser Val Lys Ala Ser Lys Phe Arg Arg Lys Ala Ser
          65                  70                  75

 gaa gaa ata gaa gat ttc cgc ctc aga cca cag agc ctg aat gga tca      288
 Glu Glu Ile Glu Asp Phe Arg Leu Arg Pro Gln Ser Leu Asn Gly Ser
      80                  85                  90

 gat tat gga gga gat att cct atc att ccg gat ctg gag gaa gta cag      336
 Asp Tyr Gly Gly Asp Ile Pro Ile Ile Pro Asp Leu Glu Glu Val Gln
  95                 100                 105                 110

 gaa gaa gac ttt gtt ttg cag gtg gca gcc cct ccc agg tag gttaaat      385
 Glu Glu Asp Phe Val Leu Gln Val Ala Ala Pro Pro Arg 
                 115                 120

 cagatatgat tggggaggca aagaacacgt gaattaatac actccagata tcatctatag    445

 tggaccttga tgtcaatctg gatctttctg gtgttgggct ccatccaggg ttcccatttt    505

 gttattccca ttctggtcat cccctgctgt atacaaggtt ctggggacgg tggcccggca    565

 gcactcctgg aacaggtcct gcctggggtt cccgcctctc gctctctctt tccttcagca    625

 tccagataaa gcgggtgatg acctaccgtg acctggacaa tgacctcatg aagtactcag    685

 ccattcagac actggatggg gagatcgacc tgaaactcct caccaaagtg ctcgcgccgg    745

 agcacgaagt ccgggaggat gatgtcggct gggactggga ccatctgttc actgaggtgt    805

 cctcagaggt cctcactgag tgggacccac tgcagacgga gaaggaggac cctgcggggc    865

 aggccaggca cacctgagcc cgtcacccat gctctagaca tgaagaaatg caatgagctt    925

 aaagctaaag aagcttgtaa gcagctccga atttttacct ggaatatttt gtaataaaaa    985

 tatttatatt cagtcaacca cattggataa ttcaattgca ataaattgct tattctgtgc   1045

 catctccaaa aaaaaaa                                                  1062




      <210> 453
      <211> 1179
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (372)..(503)

      <400> 453
 gggatccaca cagctcagaa cagttggatc ttgctcagtc tctgtcagag gaagatccct     60

 tggtaagttg gggatagtgt gatctacccc catgtcctta ttcctgcaat agctctataa    120

 gggaaggatc attcagcttt tgtagataag ctcagagagg ttaggtagct ggttcacatc    180

 agacaggaaa gcagcggcag agccgggatt tgcacccagg ctcgagtctg agtgctccct    240

 ccctcctgct gggcgggtaa actgtagaga gaggtgggga aaacagctta gatgggctta    300

 caaagctccc cgggctcagt tctggttctg acaccctcaa acacggccag cttaccccca    360

 aagaacggag g atg ccc cac aac cac ttg gag gga gat gct ttg ctg aga     410
              Met Pro His Asn His Leu Glu Gly Asp Ala Leu Leu Arg
                1               5                  10

 gtc cct gtc ctc tgc atc tgg aga gct tgg ctc aga gct gag gtg gga      458
 Val Pro Val Leu Cys Ile Trp Arg Ala Trp Leu Arg Ala Glu Val Gly
      15                  20                  25

 ggg agg gct cct ctt cca ggt cgc tca gtt gga cac cgg aat tga cca      506
 Gly Arg Ala Pro Leu Pro Gly Arg Ser Val Gly His Arg Asn 
  30                  35                  40

 gcctgcaggc tcacccatgg agtacacact gtgtcctagt caagcctgag gggcagtatc    566

 cagcctcaac ccccagcaga ggctccagac aaaggtggga gccaggccaa caatgaccca    626

 ggaggatggg atcctggatg cagctcctca caagtattgg gcaggtccga ggccccagct    686

 ctgtctgccc tcctgctcct cttctccctc ctggtcctcc tggttctcat ggctcatgag    746

 atggcgttga gacagctccc ctggcctagg gtgtcacaga gtgaacaaag caggaagaag    806

 gggaagggaa gaccccctcc cgtcaccccg tcccttacag caagaagtgt ccagatgccc    866

 ctctgcatac tcccctggtg aactgctgcc caggactggg tccccctttt agtcttgctg    926

 cgtaggggcc ccagaagaca gatatctgga tgcctcgacc ctgaaacaga ggtgggaagt    986

 ggaaagaggg aggcgagtgg cttttgagga gggggctttt gtataagagc tggaggatgc   1046

 ccgggaacca ctgagctgtt aaaataaagt ctgcaaacaa agacccagct gctgggaaaa   1106

 aagggggatt tggggggttg ttggccccgc gggggggaag gttggccggg ccaagggaag   1166

 gaaccaacca aca                                                      1179




      <210> 454
      <211> 491
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (232)..(453)

      <400> 454
 tttcgtcgca gggccgagtc ggcgcggcca catcctttat atatggtctt ttttgggcgc     60

 gcgcgacaat gtgaggagtg gggtggagcg tgtgtggtgt gtggctgcgg cctgggcaag    120

 agccgccgcg gaccatgagc tgagtaagtt ctggagggat cctgcctctt ggagccttcg    180

 cagccaggca gctgtgaact gtgagctaga gtgaagcaga aatctaggaa g atg agc     237
                                                          Met Ser
                                                            1

 tcc aag atg gtc ata agt gaa cca gga ctg aat tgg gat att tcc ccc      285
 Ser Lys Met Val Ile Ser Glu Pro Gly Leu Asn Trp Asp Ile Ser Pro
           5                  10                  15

 aaa aat ggc ctt aag aca ttt ttc tct cga gaa aat tat aaa gat cat      333
 Lys Asn Gly Leu Lys Thr Phe Phe Ser Arg Glu Asn Tyr Lys Asp His
      20                  25                  30

 tcc atg gct cca agt tta aaa gaa cta cgt gtt tta tcc aac aga gag      381
 Ser Met Ala Pro Ser Leu Lys Glu Leu Arg Val Leu Ser Asn Arg Glu
  35                  40                  45                  50

 agc aga gga gtt atg tgg act tgt tgg tta aat acg caa aga ttc ctg      429
 Ser Arg Gly Val Met Trp Thr Cys Trp Leu Asn Thr Gln Arg Phe Leu
                  55                  60                  65

 caa att cca aag ctg ttg gaa taa ataaaaatga ctacttgcag tacttggata     483
 Gln Ile Pro Lys Leu Leu Glu 
              70

 tgaaaaaa                                                             491




      <210> 455
      <211> 1024
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(621)

      <400> 455
  atg gga acc cgc acc tgt ttt ccc gcc ctg ggc acc cag cgt gga cag      48
  Met Gly Thr Arg Thr Cys Phe Pro Ala Leu Gly Thr Gln Arg Gly Gln
    1               5                  10                  15

 gct ggc cgg tgc cag ggg cag gga cct ggg ctg ctc cac ttt cac act       96
 Ala Gly Arg Cys Gln Gly Gln Gly Pro Gly Leu Leu His Phe His Thr
              20                  25                  30

 cct ggg gtt tcc ccg gga gcc ttc tct gtg gca aga agc ctg tcc tgg      144
 Pro Gly Val Ser Pro Gly Ala Phe Ser Val Ala Arg Ser Leu Ser Trp
          35                  40                  45

 aaa gtc ccg gac cac aag tca aca agg aaa gtt tct cgt gta ctg aaa      192
 Lys Val Pro Asp His Lys Ser Thr Arg Lys Val Ser Arg Val Leu Lys
      50                  55                  60

 ggt ggc gtg gat cct aca gtt tct cgt gta ctg aaa agc ggt gtg gat      240
 Gly Gly Val Asp Pro Thr Val Ser Arg Val Leu Lys Ser Gly Val Asp
  65                  70                  75                  80

 cct aca gct tct cta ctg aaa ggt ggc gtg gat cct aca gct tct cgt      288
 Pro Thr Ala Ser Leu Leu Lys Gly Gly Val Asp Pro Thr Ala Ser Arg
                  85                  90                  95

 gta cgg aaa ggc ggc gtg gat cct aca gct tct cgt gta cgg aaa ggc      336
 Val Arg Lys Gly Gly Val Asp Pro Thr Ala Ser Arg Val Arg Lys Gly
             100                 105                 110

 ggt gtg gat cct aca gct tct cta ctg aaa ggt ggc gtg gat cct aca      384
 Gly Val Asp Pro Thr Ala Ser Leu Leu Lys Gly Gly Val Asp Pro Thr
         115                 120                 125

 gct tct cgt gta cgg aaa ggc ggc gtg gat cct aca gct tct tgt gta      432
 Ala Ser Arg Val Arg Lys Gly Gly Val Asp Pro Thr Ala Ser Cys Val
     130                 135                 140

 cgg aaa ggc ggt gtg gat cct aca gct tct cta ctg aaa ggt ggc gtg      480
 Arg Lys Gly Gly Val Asp Pro Thr Ala Ser Leu Leu Lys Gly Gly Val
 145                 150                 155                 160

 gat cct aca gtt tct cat gta cgg aaa ggc ggc gtg gat cct cag ctt      528
 Asp Pro Thr Val Ser His Val Arg Lys Gly Gly Val Asp Pro Gln Leu
                 165                 170                 175

 ctc gtg tac cga aag gcg gcg tgg agc agc aca agg agc ttg agc gtt      576
 Leu Val Tyr Arg Lys Ala Ala Trp Ser Ser Thr Arg Ser Leu Ser Val
             180                 185                 190

 gca atg aga agt cat ggc tgt gaa tcc cac ccc atc acg ttt tga atg      624
 Ala Met Arg Ser His Gly Cys Glu Ser His Pro Ile Thr Phe 
         195                 200                 205

 ttgggcaaat taattaatcg ttttatccac ttactaggcg atgtatagtt tgtatacttc    684

 atgccagtca ttgttttaga ctcttaggat gcaaagataa ataagaaagt tgctttgggc    744

 aaagagtgag acctttttct taaaaaaaca aaacaaaaga attaccatgt gatgagcact    804

 tctccttctg ggtgcatacc cagtgctctg agctacagcg tctaacgttc aagccagctt    864

 ctcaatcgga ccccaggatc ctttctagag agaaatcctg tccacgtcgc cctcctagct    924

 ggcacggctg caggcaccag tgtcgtggca gcgggaaggg gaggacgggc ttggtgaaag    984

 gggactgggg cctcctcact cctggggctg ccagctccct                         1024




      <210> 456
      <211> 2839
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (872)..(1834)

      <400> 456
 ctgtgccatt tattcttggt tttttgagag cggtagacct aaagtcagcc caacaggttt     60

 aacgaatgat aaacacccaa gattatttta atgtttacaa tgaactttgc aaaatattct    120

 tcagctctgt gagaggagaa gaagggaaaa ggggaggtaa ctttacagag ggcttgattg    180

 gcacctgcct cttccgcata gatgttctca cttaaggccc agggttgctg ctggacagat    240

 gagcatactg aggttcaggg aggtctggga acttccttag ggcctcacct gagggtcagc    300

 tcccaggctg agcgtccctg actgcaatct tcctcgtgcc tccttcacca ggccaggtcc    360

 ggggcaagaa caaggcaggg ccacgcacac gtacatacag ggaggagtcc cccatcggtc    420

 ctgcagggca cagagtctct ccaggtcccc gggggttggg tcctgtccct gggggtaggg    480

 atatcatccc agggtccccc agagccagat cgcaatgggc tccttttggt ctctggattg    540

 cagtgtggaa tcttccgacg tgaactgcat gcaatgcctg catcccagac agcatcaggg    600

 aaggtggcta agaggcagtg gcagaatgca ctcaggatac acattccaga tcccagtgtc    660

 tggtctctgt cagggttggg gtccttcaca ctgttggcag gaagggtgac ctggtcttag    720

 cggcctcgcc gatgggcttg tgctgtgttt cccgtggtgc gggggcaccc caaaggacag    780

 ctgctcctac ctgtgctcac acacagccaa caggtccaag ttcagcatcg cggatgaaga    840

 cgcacggcag aacccctacc cagtgaaggc c   atg gag gtg gtc aac agc ggc     892
                                      Met Glu Val Val Asn Ser Gly
                                        1               5

 tct gag gtc tgg tac agc aat ggg ccg ggc ctc ctt gtc atc gac tgt      940
 Ser Glu Val Trp Tyr Ser Asn Gly Pro Gly Leu Leu Val Ile Asp Cys
          10                  15                  20

 gcc tcc ctg gag atc tgc agg cgg ctg gag ccc tac atg gcc ccc tcc      988
 Ala Ser Leu Glu Ile Cys Arg Arg Leu Glu Pro Tyr Met Ala Pro Ser
      25                  30                  35

 atg gtt acg tca gtc gtg tgc agc tct gag ggc aga ggg gag gag gtc     1036
 Met Val Thr Ser Val Val Cys Ser Ser Glu Gly Arg Gly Glu Glu Val
  40                  45                  50                  55

 gtc tgg tgc ctg gat gac aag gcc aac tcc ttg gtg atg tac cac tcc     1084
 Val Trp Cys Leu Asp Asp Lys Ala Asn Ser Leu Val Met Tyr His Ser
                  60                  65                  70

 acc acc tac cag ctg tgt gcc cgg tac ttc tgc ggg gtc ccc agc ccc     1132
 Thr Thr Tyr Gln Leu Cys Ala Arg Tyr Phe Cys Gly Val Pro Ser Pro
              75                  80                  85

 ctc agg gac atg ttt ccc gtg cgg ccc ttg gac acg gaa ccc ccg gca     1180
 Leu Arg Asp Met Phe Pro Val Arg Pro Leu Asp Thr Glu Pro Pro Ala
          90                  95                 100

 gcc agc cac acg gcc aac cca aag gtg cct gag ggg gac tcc atc gcg     1228
 Ala Ser His Thr Ala Asn Pro Lys Val Pro Glu Gly Asp Ser Ile Ala
     105                 110                 115

 gac gtg agc atc atg tac agt gag gag ctg ggc acg cag atc ctg atc     1276
 Asp Val Ser Ile Met Tyr Ser Glu Glu Leu Gly Thr Gln Ile Leu Ile
 120                 125                 130                 135

 cac cag gaa tca ctc act gac tac tgc tcc atg tcc tcc tac tcc tca     1324
 His Gln Glu Ser Leu Thr Asp Tyr Cys Ser Met Ser Ser Tyr Ser Ser
                 140                 145                 150

 tcc cca ccc cgc cag gct gcc agg tcc ccc tca agc ctc ccc agc tcc     1372
 Ser Pro Pro Arg Gln Ala Ala Arg Ser Pro Ser Ser Leu Pro Ser Ser
             155                 160                 165

 cca gca agt tct tcc agt gtg cct ttc tcc acc gac tgc gag gac tca     1420
 Pro Ala Ser Ser Ser Ser Val Pro Phe Ser Thr Asp Cys Glu Asp Ser
         170                 175                 180

 gac atg cta cat acg ccc ggt gct gcc tcc gac agg tct gag cat gac     1468
 Asp Met Leu His Thr Pro Gly Ala Ala Ser Asp Arg Ser Glu His Asp
     185                 190                 195

 ctg acc ccc atg gac ggg gag acc ttc agc cag cac ctg cag gcc gtg     1516
 Leu Thr Pro Met Asp Gly Glu Thr Phe Ser Gln His Leu Gln Ala Val
 200                 205                 210                 215

 aag atc ctc gcc gtc aga gac ctc att tgg gtc ccc agg cgc ggt gga     1564
 Lys Ile Leu Ala Val Arg Asp Leu Ile Trp Val Pro Arg Arg Gly Gly
                 220                 225                 230

 gat gtt atc gtc att ggc ctg gag aag gat tct ggc gcc cag cgg ggc     1612
 Asp Val Ile Val Ile Gly Leu Glu Lys Asp Ser Gly Ala Gln Arg Gly
             235                 240                 245

 cga gtc att gcc gtc tta aaa gcc cga gag ctg act ccg cat ggg gtg     1660
 Arg Val Ile Ala Val Leu Lys Ala Arg Glu Leu Thr Pro His Gly Val
         250                 255                 260

 ctg gtg gat gct gcc gtg gtg gca aag gac act gtt gtg tgc acc ttt     1708
 Leu Val Asp Ala Ala Val Val Ala Lys Asp Thr Val Val Cys Thr Phe
     265                 270                 275

 gaa aat gaa aac aca gag tgg tgc ctg gcc gtc tgg agg ggc tgg ggc     1756
 Glu Asn Glu Asn Thr Glu Trp Cys Leu Ala Val Trp Arg Gly Trp Gly
 280                 285                 290                 295

 gcc agg gag ttc gac att ttc tac cag tcc tac gag gag ctg ggc cgg     1804
 Ala Arg Glu Phe Asp Ile Phe Tyr Gln Ser Tyr Glu Glu Leu Gly Arg
                 300                 305                 310

 ctg gag gct tgc act cgc aag aga agg taa t tcctgtggaa tgactgtcac     1855
 Leu Glu Ala Cys Thr Arg Lys Arg Arg 
             315                 320

 acatcagagc tggctggccc ggggctgcag cctgacccct ctgccatcgg cctctagttc   1915

 tccaaggacc tagaagacag atggagttct cccctgaact ccttgctgct aagaagtgct   1975

 gagaagttac tcgcctggcg gtggctccag ggttctctgg ttctctggag cagagttctc   2035

 tgaatacccc atcccccaac tgctgatttt acagccccag ggaagacagt ggtatcaggc   2095

 tgggagcggc ctcctctggc ctcccccatc agtttgcagg agcaggggtg caggatcctg   2155

 ttctgagctg ggtcaaacaa agcagggccg ggccttcctg ccatccccag gtctcagatg   2215

 gaattacact agaggccctc cgctgggaag cacttgaggt agggcaggag gggggctgtg   2275

 acccctgccc tttccccgcc agagacctca ggctctcagc acattccaca ggctcctgag   2335

 tccccgaggc ctgggccagc ttgggcaagc caagatcaga tgtctctgtg ttcgggaagg   2395

 tctccgtgtg ggaaagccct tgggggatcc cgggtgagga gtgttgcccc atccagagaa   2455

 tgaatgagtt cctttaagtg ccaccgccag caagcccaga ggcacacagt ccgagtgcac   2515

 ccgcttagcc tttacattcc tctccaccga caaaaggaag gggaaactca atcagcagga   2575

 cttcagaaag ggccttgtgt ttatagcttt gtcaagtaaa tttggacgca gctggagcac   2635

 aggccctgtt tgtttgcaca taataatctt gtttatcact ttaaaaaatt cagtaatatc   2695

 tcagcagtca ggcttctggt tgtgaaatca cattgtatgg ggatttatac caaattatgt   2755

 atttgctaaa cattcactgc acacgtgtac agcggagtac gaaaaggacg ttgtcacagg   2815

 ggattctgga tacacagcaa catt                                          2839




      <210> 457
      <211> 4541
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2660)..(3460)

      <400> 457
 gtctggagct cttagagaca agataaacag cgatgtctgg ttctgctcag aggaggcttt     60

 cttaagtgag aggcacagtt ggatcagcag actcagctga gtgtgacctg ctctgttccc    120

 tccctgctga cctgggacag tcgctaccag gcagtgctgg cctctgggcg ggtgccgagg    180

 agggtcatcc ctgagcactc accaggtgag atgtctaggg tcagagaggc agcgactggt    240

 ccagagaccc agatgtgacc ctgggccatg ctcttagccc tgccctgtgc tacgctggac    300

 tcaagccctg acctctgtgg cctccctgcc ctggattcca aatccatccg gggttccagc    360

 ccctgatggg gcagagtctg gccctggaag agccactggg acagagatcc tatgggtgag    420

 gtggaggggg tggtcctcag tccaagtctg tgccctaagc tgggaccccg cgggaggtct    480

 caccaactca gacttcacat gtggtcactg agggtcattg tgggacccac tggacacagg    540

 gggtcccttg tctgggagtg gggtgaagag ccttctgccc ttgggcagtt aggtagggga    600

 ctttgagcac tgctgctttg ggacctggga agtggggacc tgggcagcgg ggtcctcgtc    660

 attgagaaca tggtcagtga gagatctggt catcatgggt tgggtcaggg gggcctggtc    720

 agcagagact tggacactgg ggcttagtga aaatatgatc agtggggaaa tagtcacggg    780

 gcctgctcag tagggcctgg ctagcagagg cctggccagc tggccactgg atgacctgac    840

 agggggtttg tccttggagc ctctttgcct ctattcatag tggggatgag tcatagcatc    900

 cctcagcact cgccaggtgc aggttttgtg ctgaccttgt agatggcctt ttccttcatc    960

 cccacagcaa ctccatgggg cggatcctgt ccccgaatgt agccattcca caggtgagat   1020

 gtctagagtc agagaggtga tgactggccc agagacccag atgtggcctg ggccgtgcac   1080

 tcagccctgc cctgtgcagt gctagactca agccctgacc tttgcagcct ccctgcctta   1140

 gatcccacat ttccctgggg ttctggaccc tgatggggtg gagggggtga ttctcagtcc   1200

 aagtctgtgc ccaaagcttg gtccccacag gaggaggtct catcaactca gacttcaggt   1260

 gcggtcactg atggttgctg tgggacccac tggacacatg gagtccttcg tctgggagtg   1320

 gggtggggag gcctctgccc tcgggcagtt gtggaaaatg aaggagctct agagggctgc   1380

 ctggagggtg atgatcgtcc ctcttggtca aaggggcttg gggactggaa ccttctctgt   1440

 ctgattctct agaggtcttg tcttcccttt gtcccaagta ttcccaagga agatggtccc   1500

 cctgggtgtt ctccaggacc aagtccccag aattctcttg ttttttcctt ggtgatccag   1560

 gaaaacgaag ccccctcctg tattgacagc tgggaattgt ggagtccacc gtcctccacc   1620

 tgagacgagc acagggtctc cacgaggaca gaggctgctt tggactcaat agaaaactgg   1680

 gcatcttcat ggtcctagaa ggatcccagg aggctgatcc tatagagacg tctggttcct   1740

 gaccccaact gcctccaggt gcctggaaca gcccatcgtg ggccctttac cctcagcagg   1800

 tggacgccgt tggtcctgcc agggatggag atggatgagc acccggatat cctgcccacc   1860

 caggggcaag gcaacatcat cattactaag tatgagcagg gacgctgagc tggggcagca   1920

 gtggacacag agcatgagcg tgttgacatc tggaaattca ccagtcgtct ctgggttgtg   1980

 tgtgagacag agctgcccgt gtcagtgccc tggaggtgaa gggaagagcc tgtgcctgct   2040

 gcgtgggaga ctggtccagg gacagggaat caggagtggt tgggccccaa agcccaggac   2100

 ccagcatcca tgggccgctg ccggaggcct ggcagctccg ctaactccat catggctcat   2160

 ttgacagcaa aggtgtcagg aaataaaatg tactgacaag tggctgaaga tgcttggaga   2220

 ctggccaaaa tataagaaca gcaagaaggt gacatggcct gtctcgaagc aggtacaaag   2280

 gcattcccct ggtgtgaggc caggcgtggg cacttctgct agacattgac aaagtcaagt   2340

 cccagaaccc aggaaataca aggaggtggg ctaccacagg gacctgagcc gcaacactgc   2400

 cgtcctcctt tatctgccgg aggaagatgc tttctgggtg gctggctcag ctgctggccg   2460

 gtgagaggca ctccctgcag gcccaaatac tgcccagctc cggaagctcc tatcacatca   2520

 ggagcaggtg ctgcacaagt ccttcccaaa gatcatgaga cagctgggca aggaagggct   2580

 atgcattgag ggttccatgc tgacgaggct cctccagtgt ttccttgatg ggccacctca   2640

 ctgctgagat gagtccccc atg agg agc tgc agg acc ttg tct gac cgc agc    2692
                      Met Arg Ser Cys Arg Thr Leu Ser Asp Arg Ser
                        1               5                  10

 ctc atg gag ggg tct cat ccc atg gaa agg ggt cct cag cac tcc aga     2740
 Leu Met Glu Gly Ser His Pro Met Glu Arg Gly Pro Gln His Ser Arg
              15                  20                  25

 gga ctg aaa ccc caa tgg gtc ctg ctc agg cca cca gcc cca gcc tgg     2788
 Gly Leu Lys Pro Gln Trp Val Leu Leu Arg Pro Pro Ala Pro Ala Trp
          30                  35                  40

 aaa ggc cag gtc ctc cca cac ctg ctg tcc cca aag aaa tcc ttc ggg     2836
 Lys Gly Gln Val Leu Pro His Leu Leu Ser Pro Lys Lys Ser Phe Gly
      45                  50                  55

 ctc acc ctg cga ctg tgg gat gtg ctt atc ttg gag ggc gag cag gta     2884
 Leu Thr Leu Arg Leu Trp Asp Val Leu Ile Leu Glu Gly Glu Gln Val
  60                  65                  70                  75

 ctg aca gcc atg gcg cat gca tca ttc aaa ata cac agg gag cac ctc     2932
 Leu Thr Ala Met Ala His Ala Ser Phe Lys Ile His Arg Glu His Leu
                  80                  85                  90

 atg aag ctt tcc tgg agc acc gtc tgg gag ttt cag gag cga ctc tct     2980
 Met Lys Leu Ser Trp Ser Thr Val Trp Glu Phe Gln Glu Arg Leu Ser
              95                 100                 105

 cag agc tgg gcc ctg gag gac aac tcg gtc ctc agg aac ctt caa acc     3028
 Gln Ser Trp Ala Leu Glu Asp Asn Ser Val Leu Arg Asn Leu Gln Thr
         110                 115                 120

 tct atg aag gaa ctc aca aaa aaa cac tgg gac ctg cca tcc cca gga     3076
 Ser Met Lys Glu Leu Thr Lys Lys His Trp Asp Leu Pro Ser Pro Gly
     125                 130                 135

 gaa ctc gag aga ggg tcc tcg agg gtg tct cct ggc att agg ccc ctc     3124
 Glu Leu Glu Arg Gly Ser Ser Arg Val Ser Pro Gly Ile Arg Pro Leu
 140                 145                 150                 155

 tgt gag ggg gac aga ttg gcc ctg ccc agc cca cca gct cag ctc cag     3172
 Cys Glu Gly Asp Arg Leu Ala Leu Pro Ser Pro Pro Ala Gln Leu Gln
                 160                 165                 170

 ggg ctc atg cca tca gcc ccc cag gac aaa agc ctt gtc ctc ccc cag     3220
 Gly Leu Met Pro Ser Ala Pro Gln Asp Lys Ser Leu Val Leu Pro Gln
             175                 180                 185

 cct ggc ctg aca ggg ttg tct cca tgg cgg agg cca agg ccc agc agc     3268
 Pro Gly Leu Thr Gly Leu Ser Pro Trp Arg Arg Pro Arg Pro Ser Ser
         190                 195                 200

 acg aag ggg ctt ccc cag aac cca ggg cag cag gct gct ctc tgg gtg     3316
 Thr Lys Gly Leu Pro Gln Asn Pro Gly Gln Gln Ala Ala Leu Trp Val
     205                 210                 215

 gcc cag agg atc aag atg tgg cca ccc tgt ttc ccg gtg agg tca ggc     3364
 Ala Gln Arg Ile Lys Met Trp Pro Pro Cys Phe Pro Val Arg Ser Gly
 220                 225                 230                 235

 ctc gta tta cat aaa aat acc tgt gct ggg act cta tgc cac acc tcc     3412
 Leu Val Leu His Lys Asn Thr Cys Ala Gly Thr Leu Cys His Thr Ser
                 240                 245                 250

 aca cag acc tgg atg ctg gga tcc atg gtt tcc tta cta caa ttt tga     3460
 Thr Gln Thr Trp Met Leu Gly Ser Met Val Ser Leu Leu Gln Phe 
             255                 260                 265

 acagggctac tgggcccctg tcacttcaac atgttacctg gacagccctg caaccacacg   3520

 acgggcctgg cccagcaagc ccactgggac cccgacacca ggccctgccc aggcttatga   3580

 cagaggaggc aggtcaggag acaccccagc aacaaggcag cacctgcctg cgatgcccct   3640

 cagtagaaga acgtggcatg gaaggagccc aggtggcaca cgcccagctg cgtcgcagcc   3700

 ccagatggct gctggacctt ggttctgggc cttggaaaat cccattcagc ggggcttggt   3760

 cccatcaagg cctctggagg gaaggctaag catagggttc ctgcagcccc agccagccag   3820

 ccagccagca gcatgccctg gggcctctga ccccacctgt gagtcccagg cccagaggtc   3880

 cctggcttca actcgagtcc taggaagaga gaggcaccag aggcaccaca ggctcccagg   3940

 gtgaccacag aggggaccag ggcacactga gccctgatgc tgtaaggatt cacatcagag   4000

 aacctgggca agacgggaga ccgtgcagta atgaggatgt ggagggctgg ctcaatgcgg   4060

 ccaacagctg tgaacactgc tgcctcttcc cagcctcatc actgcagtgc aggcagtctg   4120

 atctctggag cccagcccaa aagtgtcctg agtgccccgg cttcacatgc caatatgcca   4180

 cctggaggct tcaaggccct gcctgctgca cgcccgcctc accattgctg agcaccccat   4240

 ctgatgatga gagacttgct gtggattcct gggccggcac catttcccag gaggaccagc   4300

 gggctgcctg tgggcaggcc gcccacactg tggagggggc tgagatcagc cttcactgta   4360

 ggaagcccct acctggacac agacttgccg gctctaccta tcgccatcat ggcagcctac   4420

 atggcattac ttgtgaccag ggtgccccat ccaggtcggt ctgccctggc tgctgttttc   4480

 cctcctgcca ccctctcttt gactgcttgt gtcaataaaa ggagaactgg ccagttttca   4540

 g                                                                   4541




      <210> 458
      <211> 3401
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1679)..(2110)

      <400> 458
 ataattaaat gtttggaacc ccgcgagtta ttaatatgtt gtttgcgggc tctgaatatg     60

 tgtgtgtgat tgttgtggct aaatacatat tttacaccga gagacagcat ctgtgaatgt    120

 tttagcgaat taattcgcac tcgactatgg agaaagtgtc gcctcagagg tcaagaattt    180

 cgcaagaggt caagaacaaa ctttggttaa tgtgagcccg ggcagggggg gtgtctgaca    240

 atgtcacctt ccgaacccgt gccgcttctc cttgttaact tcctggcaaa cgaggcgggg    300

 gaaaaccttt gccctattgg ttgaaaggaa ctaacaagta ccgccacttt ttggttcgct    360

 ttttgcagac aagtaccttc gacaacgatg ccttcctggc gacaccccag actgcccttt    420

 ccaactgcct gttggaagcc gctgtaaaac gtcgtgagga gcgccgctgc tttacggctg    480

 cctctcccag actagagccc cggagcgccc accgccgtca gccgcgtctt caagctagtc    540

 ggccccgcgg agagcgagag accctgcgca ccgcagccct ctccgctgcg cccattcctg    600

 ccgccggcga tgtaactcgg ggaggcagcg gtgcccgctg gcccggggtt gagacaggcg    660

 gcaggtgcct gtgaggcggg cgggtgccgg gggccagcag gatggaggaa agcatggaag    720

 aggaggaggg gggcagctac gaggcgatga tggacgacca gaaccacaac aactgggagg    780

 ctgcggtgga cggcttccgg cagcccctgc cacctccgcc gcccccctcg tcgatcccgg    840

 cccctgcccg agagcctccg ggggggcagc tgctggcggt gcccgcggtc tccgtggaca    900

 ggaaaggccc caaggagggg ctcccgatgg ggccgcagcc accgccggag gctaatgggg    960

 tgatcatgat gttgaagagc tgcgacgcgg ccgccgccgt ggccaaggcg gcccccgccc   1020

 ccaccgccag ctccaccatc aacatcaaca cctccacctc caagttctta atgaatgtta   1080

 taactattga agattataag agcacatact ggccaaaatt ggatggtgcc atagatcaac   1140

 ttttaactca gagtcctggt gactatatcc ccatatccta tgaacagata tacagttgtg   1200

 tgtataaatg tgtatgccag cagcactcgg cactcggaac agatgtatag tgatctgatt   1260

 aaaaagataa ctaatcactt agagagagtc tcaaaggagc tgcaggccag ccctccagat   1320

 ctctatattg aaagatttaa tatagctctt ggacaatata tgggagcatt gcagagcatt   1380

 gtgcctcttt tcatatatat gaataagttt tacatcgaaa ccaagcttaa cagagactta   1440

 aaagatgacc ttataaagct gtttacggaa catgttgcag aaaagcacat ttacagccta   1500

 atgcctttac ttttagaagc ccagtcaaca ccatttcagg tcacaccttc aactatggca   1560

 aatattgtga aaggcctgta taccctcaga ccagagtggg ttcagatggc tccaactcta   1620

 ttttctaaat ttattccaaa cattctccct ccggcggtgg aatctgaact ttctgaat     1678                                                                 
 atg ctg ctc aag atc aga aat ttc aaa gag aac tta tac aga atg gtt     1726
 Met Leu Leu Lys Ile Arg Asn Phe Lys Glu Asn Leu Tyr Arg Met Val
   1               5                  10                  15

 tta caa ggg gtg acc agt ccc gga aga gag ctg ggg atg agt tgg ctt     1774
 Leu Gln Gly Val Thr Ser Pro Gly Arg Glu Leu Gly Met Ser Trp Leu
              20                  25                  30

 ata ata gct cgt cag cat gtg caa gtt cca ggg ggt aca gat agt gaa     1822
 Ile Ile Ala Arg Gln His Val Gln Val Pro Gly Gly Thr Asp Ser Glu
          35                  40                  45

 tgt att gaa tat gct ttc ctt cct gaa aag agg aca cac tgg agc tgc     1870
 Cys Ile Glu Tyr Ala Phe Leu Pro Glu Lys Arg Thr His Trp Ser Cys
      50                  55                  60

 aga gac tgt att cag agc aca gtg ggg gct gca cac act cag gag ctc     1918
 Arg Asp Cys Ile Gln Ser Thr Val Gly Ala Ala His Thr Gln Glu Leu
  65                  70                  75                  80

 tgt cac aaa gct gtt cat gga aga gga tgt tgg act tct tac ttg gtt     1966
 Cys His Lys Ala Val His Gly Arg Gly Cys Trp Thr Ser Tyr Leu Val
                  85                  90                  95

 tgt aat ttt aaa aca aaa act aaa aaa aaa aaa aac gtt gct gct aga     2014
 Cys Asn Phe Lys Thr Lys Thr Lys Lys Lys Lys Asn Val Ala Ala Arg
             100                 105                 110

 ctt ggg ggt gat ttt gaa atg gga caa tct ttt aat gag ttt atc tac     2062
 Leu Gly Gly Asp Phe Glu Met Gly Gln Ser Phe Asn Glu Phe Ile Tyr
         115                 120                 125

 aga ttc tgt gag gaa aaa gca tct cag aaa gtg acc att tct aag tga     2110
 Arg Phe Cys Glu Glu Lys Ala Ser Gln Lys Val Thr Ile Ser Lys 
     130                 135                 140

 aatctgacag ccaaaatcag cagcttcctc caaaaatata agagcagaag aatttttttt   2170

 ttaagcactt gttttgttca tttgtggact tggcattttg gtgtattggt ttcacatgtc   2230

 aggatctctt ttgctttaaa accaagcaga tcattacagt acagtatttt tcacccacaa   2290

 ccaaaacaac cccttttaaa agagttggtc tttgtttagc attagaaagt cttgttaaag   2350

 gaaaatgcta actctgcttt tgctagaact ttcccccatc agttcacaac tttcttctac   2410

 tctgtgcctt gagctttgtg cactttgcaa ctgtgtgacc atgttgtcaa actcctcctg   2470

 gagaagtgta tggtatctaa actcacccac caagatggca ggtgtggccc tgtagcagga   2530

 tgctaattaa gtgggaaaat agaaaccttt tgcacatggg tcggattttc ccctggttca   2590

 ccagagcata ttcatattaa tgttggggac caactctcct agagcatttc cattccctgt   2650

 gccacttaac acgatgtctg tcaccagctg ctatagtatt ggcagtactc tagtttaggg   2710

 atgggcggta ctttagcacg gaagcttccc ttagtattat tgagagctac ttcctgcgat   2770

 gctctaggaa gcagatacag ttattaagtc caaatacaca gtggtgtggg gttcctgatc   2830

 acttcatttt aaatgaatga gataattact taaaaaaagt ctgtcatttg aacattatat   2890

 ttgagtgtga tagggaagaa gtagcactgc tgtcctaagg ctcccttcca gctgtggcaa   2950

 agctatattt ctgtttctcc acatccacag tgctttttag tccatcataa aagtttctga   3010

 agcttattct agctgttgtt gaaagcccaa gaaaaataga tgtggcaaga gaaaaatact   3070

 tttcttctca attttgcttg aatcttaatt gagcataggc ttctctacta ggcaacatca   3130

 gactaatagt atttacctct tcagagaact tgaggggaaa agaaacatcc cagggatgct   3190

 gtcgcatgtc tgctctgcag gttcttcata cagctgcctc tgccaattca gtttattttt   3250

 tggggggagt ggtgtgggtg ggagagttag aagtgggata ttgggagcaa gtaagtcacc   3310

 caataattga agtccttgat ttgtaaaact gttatacaga gaagtaaaga taaaggttgt   3370

 cagatttatt ttttaaagta aaaaaaaaaa a                                  3401




      <210> 459
      <211> 600
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (95)..(556)

      <400> 459
 tttcgtgtgc atgttgtagt tctcaaaacc caaaaaaatc taagagaaac ccagcagcaa     60

 gaaacacaga ggtttgggtg tcagcatcgg agga    atg tct cac gtc tgc ctt     112
                                          Met Ser His Val Cys Leu
                                            1               5

 gtc ccc cag acc ccg tcc ctg tgt ctg ggc aaa ggc acg ccc cgc tcc      160
 Val Pro Gln Thr Pro Ser Leu Cys Leu Gly Lys Gly Thr Pro Arg Ser
              10                  15                  20

 agg tcg gcc cca ttt cag agc agt ggc cct cat agg ctt tgt gcc tct      208
 Arg Ser Ala Pro Phe Gln Ser Ser Gly Pro His Arg Leu Cys Ala Ser
          25                  30                  35

 tca ttt agt cta aga aac tac cta gga tat ttt tgt aga ggt gac atc      256
 Ser Phe Ser Leu Arg Asn Tyr Leu Gly Tyr Phe Cys Arg Gly Asp Ile
      40                  45                  50

 act gtc tgg ctg cag aag cat ttg ctt gga ttt ggg gaa gtg agg gct      304
 Thr Val Trp Leu Gln Lys His Leu Leu Gly Phe Gly Glu Val Arg Ala
  55                  60                  65                  70

 ggg aga gga ggg ctt aca gag gca gga tgc cca ggc cca ttg cgg gtg      352
 Gly Arg Gly Gly Leu Thr Glu Ala Gly Cys Pro Gly Pro Leu Arg Val
                  75                  80                  85

 gct gat ggg ggg tgg gct tac cat ctg cag gga cag ggt gga ggg aga      400
 Ala Asp Gly Gly Trp Ala Tyr His Leu Gln Gly Gln Gly Gly Gly Arg
              90                  95                 100

 gga gcc acc cca ggc agg ggg aag ggg tgt gcc ccc ttt ggg ata tgg      448
 Gly Ala Thr Pro Gly Arg Gly Lys Gly Cys Ala Pro Phe Gly Ile Trp
         105                 110                 115

 agg ttt tgg ggg gct ggt ggg agg gaa ttc cag ggg tcg agc ccc tgg      496
 Arg Phe Trp Gly Ala Gly Gly Arg Glu Phe Gln Gly Ser Ser Pro Trp
     120                 125                 130

 gga aaa gga ggc ttt aag gtc agt gga aaa gtg ggt gcc aaa gtc tgg      544
 Gly Lys Gly Gly Phe Lys Val Ser Gly Lys Val Gly Ala Lys Val Trp
 135                 140                 145                 150

 aag atg agt tga aac ctggagtttg aagcccgggg aggattttgt tggagtgttg      599
 Lys Met Ser 


 g                                                                    600




      <210> 460
      <211> 2481
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(1542)

      <400> 460
 gtggatctgt ctcggggaag caccccgctg ggccctgagc agcccgaaga aggcccggga     60

 ggcctgcccc cc    atg ctg tgc cca gcc agc ctg aac atc tgc agt gtc     108
                  Met Leu Cys Pro Ala Ser Leu Asn Ile Cys Ser Val
                    1               5                  10

 gtc tcg ctg tcc gcg tct ccc agg acg cat gaa ggt ggc acc aag ctc      156
 Val Ser Leu Ser Ala Ser Pro Arg Thr His Glu Gly Gly Thr Lys Leu
          15                  20                  25

 ctg gcc ctg tcc gcc aaa ggc cgc ctg atg acc tgc agc ctg gac ctg      204
 Leu Ala Leu Ser Ala Lys Gly Arg Leu Met Thr Cys Ser Leu Asp Leu
      30                  35                  40

 gac tct gag atg cct ggc cca gcc agg atg acc aca gag agt gca ggt      252
 Asp Ser Glu Met Pro Gly Pro Ala Arg Met Thr Thr Glu Ser Ala Gly
  45                  50                  55                  60

 cag aaa ata aag gag ctg ctg tct gga att ggc aac atc tct gag aga      300
 Gln Lys Ile Lys Glu Leu Leu Ser Gly Ile Gly Asn Ile Ser Glu Arg
                  65                  70                  75

 gtg tct ttt cta aag aag gcg gtt gac cag cgg aac aag gca ctg aca      348
 Val Ser Phe Leu Lys Lys Ala Val Asp Gln Arg Asn Lys Ala Leu Thr
              80                  85                  90

 agc ctc aac gag gcc atg aac gtg agc tgt gca ctg ctg tca agc ggc      396
 Ser Leu Asn Glu Ala Met Asn Val Ser Cys Ala Leu Leu Ser Ser Gly
          95                 100                 105

 acg ggc ccc aga ccc atc tcc tgc acc acc agc acc acc tgg agc cgc      444
 Thr Gly Pro Arg Pro Ile Ser Cys Thr Thr Ser Thr Thr Trp Ser Arg
     110                 115                 120

 ctg cag aca cag gat gtg ctc atg gcc acc tgc gtg cta gag aac agc      492
 Leu Gln Thr Gln Asp Val Leu Met Ala Thr Cys Val Leu Glu Asn Ser
 125                 130                 135                 140

 agc agc ttc agc ctg gac cag ggg tgg acc ctg tgc atc cag gtg ctc      540
 Ser Ser Phe Ser Leu Asp Gln Gly Trp Thr Leu Cys Ile Gln Val Leu
                 145                 150                 155

 acc agc tcc tgt gct ctc gac ctg gac tcg gcc tgc tcc gcc atc acc      588
 Thr Ser Ser Cys Ala Leu Asp Leu Asp Ser Ala Cys Ser Ala Ile Thr
             160                 165                 170

 tac acc atc ccc gtg gac cag ctc ggc ccc ggt gct cgg cgg gag gtg      636
 Tyr Thr Ile Pro Val Asp Gln Leu Gly Pro Gly Ala Arg Arg Glu Val
         175                 180                 185

 acg cta ccc ctg ggc cct ggt gag aac ggc ggg ctc gac ctg ccc gtg      684
 Thr Leu Pro Leu Gly Pro Gly Glu Asn Gly Gly Leu Asp Leu Pro Val
     190                 195                 200

 acc gtg tcc tgc acg ctg ttc tac agt ctc agg gag gtg gtg ggc ggg      732
 Thr Val Ser Cys Thr Leu Phe Tyr Ser Leu Arg Glu Val Val Gly Gly
 205                 210                 215                 220

 gcc ctt gcc ccc tca gac tct gag gac ccc ttt ctg gat gag tgc ccc      780
 Ala Leu Ala Pro Ser Asp Ser Glu Asp Pro Phe Leu Asp Glu Cys Pro
                 225                 230                 235

 tcc gac gtc ctg ccc gag caa gag ggt gtt tgc ctg ccc ctg agc agg      828
 Ser Asp Val Leu Pro Glu Gln Glu Gly Val Cys Leu Pro Leu Ser Arg
             240                 245                 250

 cac aca gtg gac atg ctg cag tgt ctg cgc ttc cct ggc ctg gcc ctg      876
 His Thr Val Asp Met Leu Gln Cys Leu Arg Phe Pro Gly Leu Ala Leu
         255                 260                 265

 cca cac aca cgg gcc ccc tcc cca ctc ggc ccc acc cga gac cct gtg      924
 Pro His Thr Arg Ala Pro Ser Pro Leu Gly Pro Thr Arg Asp Pro Val
     270                 275                 280

 gcc act ttt ctg gaa act tgt cgg gag cct ggc agc cag cca gca gga      972
 Ala Thr Phe Leu Glu Thr Cys Arg Glu Pro Gly Ser Gln Pro Ala Gly
 285                 290                 295                 300

 ccc gcc tcc ctg cgg gcc gag tac ctg ccc cca tct gtg gct tcc atc     1020
 Pro Ala Ser Leu Arg Ala Glu Tyr Leu Pro Pro Ser Val Ala Ser Ile
                 305                 310                 315

 aag gtg tcg gcg gag ctg ctc aga gct gcc ttg aag gac ggc cac tca     1068
 Lys Val Ser Ala Glu Leu Leu Arg Ala Ala Leu Lys Asp Gly His Ser
             320                 325                 330

 ggc gtg ccc ctg tgc tgt gcc acc ctg cag tgg ctc ctt gct gag aat     1116
 Gly Val Pro Leu Cys Cys Ala Thr Leu Gln Trp Leu Leu Ala Glu Asn
         335                 340                 345

 gct gct gtg gac gtc gtg agg gcc cga gca cta tct tcc atc cag gga     1164
 Ala Ala Val Asp Val Val Arg Ala Arg Ala Leu Ser Ser Ile Gln Gly
     350                 355                 360

 gtg gcc cct gat ggc gcc aac gtt cac ctc atc gtc cga gag gtg gcc     1212
 Val Ala Pro Asp Gly Ala Asn Val His Leu Ile Val Arg Glu Val Ala
 365                 370                 375                 380

 atg acc gac ctg tgc cca gca ggg ccc atc cag gcc gtg gag att caa     1260
 Met Thr Asp Leu Cys Pro Ala Gly Pro Ile Gln Ala Val Glu Ile Gln
                 385                 390                 395

 gtg gaa agc tcc tct ctg gcc gac att tgc agg gcg cac cat gcc gtt     1308
 Val Glu Ser Ser Ser Leu Ala Asp Ile Cys Arg Ala His His Ala Val
             400                 405                 410

 gtc ggg cgc atg cag acg atg gtg aca gag cag gcc gcc cag ggc tcc     1356
 Val Gly Arg Met Gln Thr Met Val Thr Glu Gln Ala Ala Gln Gly Ser
         415                 420                 425

 agc gct cct gat ctc cgt gtg cag tac ctc cgc cag atc cac gcc aac     1404
 Ser Ala Pro Asp Leu Arg Val Gln Tyr Leu Arg Gln Ile His Ala Asn
     430                 435                 440

 cac gag aca ctg ctg cgg gag gtg cag acc ctg cgc gac cgg ctc tgc     1452
 His Glu Thr Leu Leu Arg Glu Val Gln Thr Leu Arg Asp Arg Leu Cys
 445                 450                 455                 460

 acg gag gat gag gcc agc tcc tgt gcc acc gcc cag agg ctg cta cag     1500
 Thr Glu Asp Glu Ala Ser Ser Cys Ala Thr Ala Gln Arg Leu Leu Gln
                 465                 470                 475

 gtg tac cgg cag ctg cgc cac ccc agc ctc atc ctg ctg tga ccaggcg     1549
 Val Tyr Arg Gln Leu Arg His Pro Ser Leu Ile Leu Leu 
             480                 485

 ggcctgcccc tgggctctgg ccacgcttcc agcctctgtc acagcccccc caggcctcat   1609

 gggttagagg gaaaccgagc tggcctggcc agagccgtca gggaaggtag gacctggcca   1669

 cgtaggagca gaacgctcat gaaagtgctt ggaggccgtg gagcacaaag cagattctga   1729

 ttgggagcaa ccgaggcggg ctctgaacct ggccggtcca gcttcgcgtc ctctgctggt   1789

 gtctctcctt ctctgaccgc ggccgcagcc cctgcactcg ccttcctcac tgctgggcag   1849

 ccttcccacc accgcagcag cccctgaggc caggaggcag tgcagggcat tctggacccg   1909

 gagggccaga gaaacaggat ttctggggtt tggacttggg gtgagtttgt aactgttgct   1969

 gccacaccac caggagcacc ggctgcccct ctgggtggca ctaccaggtg ccccacggta   2029

 cccttgtcac actgttcaca cctgcccggc tgcccactct gggaccccga ggtaggaggg   2089

 tgctccctga gaccaaagca caaaacagca tgcagggagc tcctgcaagt gcccgtggtc   2149

 tcgtgccaca ccaaggaagg gccagcgggt ggcctgtggc cggaatgctc aacaactagg   2209

 tgcctccggc cggggcagta cccagcactg tgcactattt tcagggccac tcagggtggc   2269

 gctgtggccg ggggggggcc ctgagcccca gcccccagcc tcctccctca gcctgggcta   2329

 cggcccacct cctggtgctg gtgttttcat ctggggaggg tgctcgcgcc gctcccgctg   2389

 caggcactgt ccgcgatgag tgcgggtagg agccgtgagg tgcttctctg ctgtgacaaa   2449

 cgaccctgtc tgtccgtgaa aaaaaaaaaa aa                                 2481




      <210> 461
      <211> 1094
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (137)..(715)

      <400> 461
 acagaaggcg gggccagcgc cgctgccggg tgctggaggc gccattggag ccggcttggc     60

 tggcgagccc ggctgaggag cctcttgggt cgcacttacc gccgcgtccg ctcccggtcc    120

 ctggcccctc agcggc    atg gcg tgc ggg gcg acg ctg aag cgg ccc atg     169
                      Met Ala Cys Gly Ala Thr Leu Lys Arg Pro Met
                        1               5                  10

 gag ttc gag gcg gcg ctg ctg agc ccc ggc tcc ccg aag cgg cgg cgc      217
 Glu Phe Glu Ala Ala Leu Leu Ser Pro Gly Ser Pro Lys Arg Arg Arg
              15                  20                  25

 tgc gcc cct ctg ccc ggc ccc act ccg ggc ctc agg ccc ccg gac gcc      265
 Cys Ala Pro Leu Pro Gly Pro Thr Pro Gly Leu Arg Pro Pro Asp Ala
          30                  35                  40

 gag ccg ccg ccg ccg ttt cag acg cag acc cca ccg cag agt ctg cag      313
 Glu Pro Pro Pro Pro Phe Gln Thr Gln Thr Pro Pro Gln Ser Leu Gln
      45                  50                  55

 cag ccc gcc ccg ccc ggc agc gag cgg cgc ctt cca act ccg gag caa      361
 Gln Pro Ala Pro Pro Gly Ser Glu Arg Arg Leu Pro Thr Pro Glu Gln
  60                  65                  70                  75

 att ttt cag aac ata aaa caa gaa tat agt cgt tat cag agg tgg aga      409
 Ile Phe Gln Asn Ile Lys Gln Glu Tyr Ser Arg Tyr Gln Arg Trp Arg
                  80                  85                  90

 cat tta gaa gtt gtt ctt aat cag agt gaa gct tgt gct tcg gaa agt      457
 His Leu Glu Val Val Leu Asn Gln Ser Glu Ala Cys Ala Ser Glu Ser
              95                 100                 105

 caa cct cac tcc tca gca ctc aca gca cct agc tct cca ggt tcc tca      505
 Gln Pro His Ser Ser Ala Leu Thr Ala Pro Ser Ser Pro Gly Ser Ser
         110                 115                 120

 tgg atg aag aag gac cag ccc aca ttt acc ctc cga caa gtt ggc ata      553
 Trp Met Lys Lys Asp Gln Pro Thr Phe Thr Leu Arg Gln Val Gly Ile
     125                 130                 135

 ata tgt gag cgc ctc tta aaa gac tat gaa gat aaa att cgg gag gag      601
 Ile Cys Glu Arg Leu Leu Lys Asp Tyr Glu Asp Lys Ile Arg Glu Glu
 140                 145                 150                 155

 tat gag caa atc ctc aat acc aaa cta gca gaa caa tat gaa tct ttt      649
 Tyr Glu Gln Ile Leu Asn Thr Lys Leu Ala Glu Gln Tyr Glu Ser Phe
                 160                 165                 170

 gtg aaa ttc aca cat gat cag att atg cga cgg tat ggg aca agg cca      697
 Val Lys Phe Thr His Asp Gln Ile Met Arg Arg Tyr Gly Thr Arg Pro
             175                 180                 185

 aca agc tat gtg tca tga agcttt gtcacatatc tgggtaccag gtttgacctc      751
 Thr Ser Tyr Val Ser 
         190

 aagagatggc tgctgtacac tttttgcaac tggtttgatg tcacatttca gctccaactt    811

 tgcatcctga gaacacttaa acgtttctgc aggtccattt tatacaactt gaaagaccgt    871

 aaaactttct ggttgccaca agcatatctt tcttttctgc tcatccaata aacagctggc    931

 cactggaaat ttcacaaatc cgacacagta caaatgccta tggctacaag agtccaccat    991

 tgaaaggcgg aaggggtatg ggatggttag atatgatgca atttttactg gttgctgatg   1051

 cgaatagaaa ctgtgcaagt gctcacgata agactcgctg atc                     1094




      <210> 462
      <211> 999
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (342)..(545)

      <400> 462
 tagtccctgc ggtggaattc atgtcagaaa ggcaagccta tgcaaagagt ttttaagagg     60

 gctattaatt cctgttaagt caactggaat agagaaggat acaggtactt ttcctgtgtg    120

 tagaacccaa agtttgaaac cacctttgag gcactgcact aagtatttca tagtcaaaaa    180

 gcacttacct gaaaattaaa gctgaaggtt ttctttactg atttgaaggg catctgggaa    240

 tttcatttcg tagaaactcc acttaaacat ggcaagagtt tctcaagata taaaaattct    300

 ccctgattgt aacaagtact gagacagtga acaaatcctg t    atg tca cat ttg     353
                                                  Met Ser His Leu
                                                    1

 atg acc tta gca att ata cag aca ggg aaa atg ttt atc ttg att tct      401
 Met Thr Leu Ala Ile Ile Gln Thr Gly Lys Met Phe Ile Leu Ile Ser
   5                  10                  15                  20

 gct aca gca aca ctg aag cca gag gtg tct gag ctt tgg cta atg tca      449
 Ala Thr Ala Thr Leu Lys Pro Glu Val Ser Glu Leu Trp Leu Met Ser
                  25                  30                  35

 ctt gat gta ggt cag ccc tac tgt gag tgt caa ccc tgg ttt cta aat      497
 Leu Asp Val Gly Gln Pro Tyr Cys Glu Cys Gln Pro Trp Phe Leu Asn
              40                  45                  50

 gtg ctg ctg gag gaa tcc cac ttc act tcc agt tta agt gtc agc tga      545
 Val Leu Leu Glu Glu Ser His Phe Thr Ser Ser Leu Ser Val Ser 
          55                  60                  65

 ggcctcgcct gatcatttga ttcagagtag ccctagttct cacaacacta tctgaatttt    605

 ctacatatca catcacagac taatattgtt tataccagtc ttgtttcctc ctaataaaat    665

 ataagtgcca tgaaagaaca gaccttgtct tttcctaaac aggtcctgac acctcttaga    725

 tcctcagtaa atctttgtta catgaatgca tttgagcttt cactctcttg gtctgacctt    785

 cccacaatga tttcccaagg gcttcacatc aggatctaca ggtaagaaga ggattaagga    845

 aggccaactt gacccttcgg aatgggatcc acaagggatg ggcaccgggg atttaacacg    905

 aatttggggt agaaataagg gcctcttggg cgttaagaga gccatcaaac aagggcgcct    965

 tttttttctt aatccgggcc ctgtgtccgg tcct                                999




      <210> 463
      <211> 729
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (438)..(599)

      <400> 463
 ttcgaggtgt cccctgtctc tttgaggttc ctccgtgaca ctggctactt gtaactctac     60

 actgtcagca aattattccc aaaggtgagt ccccgtggga agtggaaacc cagcgaatca    120

 ccaggacccg cctgattccg aaaggctgat gctgctggga accgccccgc agctccggcg    180

 gtccccgcct gcctgcgcgg ccttcagctg gggttacgga gggctcccag cgctgatcca    240

 aaccgcgttc cagcgggtgg gcgggccctg gccagcgagg ccgaagcaga acaacccgcc    300

 caggcgtcca gagcgtatcc aaccctggag aacctgcccc ggaaccaaga gccgcagcca    360

 gctcaggcct ctcgagtggg gcctttccag cccctgcaac agatcccggg atctgtagtt    420

 gggcggaggg gctcgtt   atg gga aag ggg tgc gtg cgc gtt tgt gct aaa     470
                      Met Gly Lys Gly Cys Val Arg Val Cys Ala Lys
                        1               5                  10

 aca aga aag gca aga atc tcc gag aac aaa act ctg gtc ctc gcc tgg      518
 Thr Arg Lys Ala Arg Ile Ser Glu Asn Lys Thr Leu Val Leu Ala Trp
              15                  20                  25

 ccg ggg acc gca gaa gac agg ggc ggc agc gcc aag gcg ggt cag ggg      566
 Pro Gly Thr Ala Glu Asp Arg Gly Gly Ser Ala Lys Ala Gly Gln Gly
          30                  35                  40

 ccg gtc cag cca agt ttg ctc cgg ctt aga taa actttctg atggcagttt      617
 Pro Val Gln Pro Ser Leu Leu Arg Leu Arg 
      45                  50

 ttcctggttg cagcctgggt tccttgtaac cggatggaga cgagagatct ggacttctga    677

 acatctaccg gaaaagataa aatgtgcaag cccttcagaa cgctggggag gg            729




      <210> 464
      <211> 1106
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (661)..(891)

      <400> 464
 aaaaacctcc cttaagatct ttccaggtca tcaatttgat gtgcatagta ttccactgtg     60

 tgcctggatt tctataattg aatctaattt tagacagttt gagtaattaa aattatttct    120

 attaacaaat aatagattgc taataatata tattatgctg ttttggatat actaaatatt    180

 tgctcacatc cttaatatat tttttaaaat tcctaacaat agtactgttg agataaaagt    240

 tgagcacatt ttgagacttc ttccaaattg gtccctagaa agttacactg gtttgtactc    300

 tcacttatgt cactgtttat accaccactg actgctgcct gctttattat ttctttaatg    360

 agttggactg aacagtggtt aatcctgact ctgtttttga ctgacagtta acagttacat    420

 gaaccattca tattacagct cttacttaaa tttgaccaag ccaggatata tctgttaggc    480

 cacattcatt tagggatcat gttttccaaa gcaggtttgg gcaaaattaa tccacaggac    540

 tgaaaggtat acatctgtga gttttgttct cacttccacc tctaatttga agaacacttt    600

 aattgacaca gaatacattt cacatattta acctctacaa taagttctga cacattttcc    660
                                                                 
 atg aaa caa acc atc gct ata ttc aag ata atg aac cta tct atc ata      708
 Met Lys Gln Thr Ile Ala Ile Phe Lys Ile Met Asn Leu Ser Ile Ile
   1               5                  10                  15

 ctc cca aat tcc ttc ttg cat ctt tgt aat ttc tca ctc ttc ctt ctc      756
 Leu Pro Asn Ser Phe Leu His Leu Cys Asn Phe Ser Leu Phe Leu Leu
              20                  25                  30

 cct ctc ccc gtc cca tcc caa cca ctg atc tgc tca ggc aac tac caa      804
 Pro Leu Pro Val Pro Ser Gln Pro Leu Ile Cys Ser Gly Asn Tyr Gln
          35                  40                  45

 tct tct ttc tgt cac tat aga tta att tgc att ttt aaa gaa att tac      852
 Ser Ser Phe Cys His Tyr Arg Leu Ile Cys Ile Phe Lys Glu Ile Tyr
      50                  55                  60

 ata cat gga acc ata cat cat cta tgc ttt gta gta tga ctcctgtcac       901
 Ile His Gly Thr Ile His His Leu Cys Phe Val Val 
  65                  70                  75

 tcagtacaat tattttgaga ttcatttatg ttattgtatg tatcaatagt tcatcccttt    961

 tattggtaag taacattttt ttgtataggt ataccatgat ttgttgatga acaaatttac   1021

 ctgttgatga acatttacgt tgttaccaag atttttgcta ttgaaaataa agtttttatg   1081

 aatatttata tataaaaaaa aaaaa                                         1106




      <210> 465
      <211> 464
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (121)..(390)

      <400> 465
 tctgcccgcc gctggcctgg ccccgtctgt ctctctcagc agctgtcttt ctcgcgccca     60

 ctggccggtc tctcctcttc cccgcagttg cctccttctc tgcctgcctg ggtggccgcc    120
                                                                 
 atg ggc cgg aag cgg ctc atc act gat tcc tac ccg gtt gtg aag agg      168
 Met Gly Arg Lys Arg Leu Ile Thr Asp Ser Tyr Pro Val Val Lys Arg
   1               5                  10                  15

 agg gag ggg ccc gct ggg cac agc aag ggg gag ctg gca ccc gag cta      216
 Arg Glu Gly Pro Ala Gly His Ser Lys Gly Glu Leu Ala Pro Glu Leu
              20                  25                  30

 ggg gag gag ccc cag ccc cgc gac gag gag gaa gcg gag ctg gag ctg      264
 Gly Glu Glu Pro Gln Pro Arg Asp Glu Glu Glu Ala Glu Leu Glu Leu
          35                  40                  45

 ctg agg cag ttt gac ctg gcc tgg cag tac ggg ccc tgc acc ggt gag      312
 Leu Arg Gln Phe Asp Leu Ala Trp Gln Tyr Gly Pro Cys Thr Gly Glu
      50                  55                  60

 aac cca ccc agc ccc acg gag gcg cct ctc cca gcc agt cac cca cac      360
 Asn Pro Pro Ser Pro Thr Glu Ala Pro Leu Pro Ala Ser His Pro His
  65                  70                  75                  80

 gtc tct gaa gtc acc caa gcg ctt gcg tga c tctgaccctc aggaactgtc      411
 Val Ser Glu Val Thr Gln Ala Leu Ala 
                  85

 tccccccaac acacacattc ttcagctcag actctacccc accccccaca agt           464




      <210> 466
      <211> 931
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (132)..(869)

      <400> 466
 cccacactaa agagctgtgt taatattgac ggtatttgca gtgtcccttg cccacggccc     60

 catccgccac ccgtgactgg ggcacttccc tcctgccctc tggccgtcag cctcttgcag    120

 caagcatttc c atg aac acc aag tcg gag att cgt cca cgc tgg tgc ctg     170
              Met Asn Thr Lys Ser Glu Ile Arg Pro Arg Trp Cys Leu
                1               5                  10

 cag gcc tca tgg gag gat ttg atg aag atg tta aag cga aag tgg aga      218
 Gln Ala Ser Trp Glu Asp Leu Met Lys Met Leu Lys Arg Lys Trp Arg
      15                  20                  25

 acc ttc tcg gga ttt cca gcc tgg aaa aaa cgg acc ctg tta ggg agg      266
 Thr Phe Ser Gly Phe Pro Ala Trp Lys Lys Arg Thr Leu Leu Gly Arg
  30                  35                  40                  45

 ggg ccg gct cct tcc ctg gca gca aca tcc ttg ccc ttg tca cac aag      314
 Gly Pro Ala Pro Ser Leu Ala Ala Thr Ser Leu Pro Leu Ser His Lys
                  50                  55                  60

 tca gcc tcc atc tgc gca gct ctg tgg atg cgc tgc tgg agg gca aca      362
 Ser Ala Ser Ile Cys Ala Ala Leu Trp Met Arg Cys Trp Arg Ala Thr
              65                  70                  75

 ggt atg tca ctg gct ggt tca gcc cct acc acc gcc agc gga agc tca      410
 Gly Met Ser Leu Ala Gly Ser Ala Pro Thr Thr Ala Ser Gly Ser Ser
          80                  85                  90

 tcc acc cgg tca tgg ttc agc aca tcc agc ccg cag cgc tca gcc tcc      458
 Ser Thr Arg Ser Trp Phe Ser Thr Ser Ser Pro Gln Arg Ser Ala Ser
      95                 100                 105

 tgg cac agt gga gca ccc tcg tgc agg agc tgg agg ctg ccc tgc agc      506
 Trp His Ser Gly Ala Pro Ser Cys Arg Ser Trp Arg Leu Pro Cys Ser
 110                 115                 120                 125

 tgg ctt tct acc cgg atg ccg tgg agg agt ggc tgg agg aaa acg tgc      554
 Trp Leu Ser Thr Arg Met Pro Trp Arg Ser Gly Trp Arg Lys Thr Cys
                 130                 135                 140

 acc cca gcc tgc agc ggc tgc aag ctc tgc tgc agg acc tca gcg agg      602
 Thr Pro Ala Cys Ser Gly Cys Lys Leu Cys Cys Arg Thr Ser Ala Arg
             145                 150                 155

 tgt ctg ccc ccc cgc tgc cac cca cca gcc ctg gca ggg acg ttg ctc      650
 Cys Leu Pro Pro Arg Cys His Pro Pro Ala Leu Ala Gly Thr Leu Leu
         160                 165                 170

 agg acc cct gag ggg aga gct cat gcc agg ggg ctc ctg ctg gag gct      698
 Arg Thr Pro Glu Gly Arg Ala His Ala Arg Gly Leu Leu Leu Glu Ala
     175                 180                 185

 ggg ggg gct ctg cac tgc caa atg gcc tgg gca ata cgg gcc cac gtg      746
 Gly Gly Ala Leu His Cys Gln Met Ala Trp Ala Ile Arg Ala His Val
 190                 195                 200                 205

 ggc gtc gtg ccc tct ggc cca gca gtg tct tgc cca cac tca gtt cct      794
 Gly Val Val Pro Ser Gly Pro Ala Val Ser Cys Pro His Ser Val Pro
                 210                 215                 220

 gag ggc cct ggg cag ccc ctg ggg gag aga cta gaa aac aca gaa gga      842
 Glu Gly Pro Gly Gln Pro Leu Gly Glu Arg Leu Glu Asn Thr Glu Gly
             225                 230                 235

 agc agc aca ggg aga ccc gct ttg tga tctgc atgtgtgaca ctgattcttt      894
 Ser Ser Thr Gly Arg Pro Ala Leu 
         240                 245

 ggaaataaag agtggaagct gcaggtgaaa aaaaaaa                             931




      <210> 467
      <211> 1649
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (214)..(1083)

      <400> 467
 agagtttcgg aggcggtgac cgtgacgtag aaggtggaga ccgcttcacc ctgatcaggg     60

 agtatcggct gcgggtgcgc aaggcgtcca ggagtgacct ggggctgtgg agagcgaccc    120

 gtggccttgt gtttcagagt ttaccaccta ggatgacttc agtgactaga tcagagatca    180

 tagatgaaaa aggaccagtg atgtctaaga ctc atg atc atc aat tgg aat caa     234
                                      Met Ile Ile Asn Trp Asn Gln
                                        1               5

 gtc tca gtc ctg tgg aag tgt ttg cta aaa caa tct gcc agt tat caa      282
 Val Ser Val Leu Trp Lys Cys Leu Leu Lys Gln Ser Ala Ser Tyr Gln
          10                  15                  20

 gac agg agg caa tcc ggg cgg cga gca agt atg aaa gaa acg aac cgg      330
 Asp Arg Arg Gln Ser Gly Arg Arg Ala Ser Met Lys Glu Thr Asn Arg
      25                  30                  35

 cgg aag tcg ctg cat ccc att cac cag ggc atc aca gag ctc agc cgg      378
 Arg Lys Ser Leu His Pro Ile His Gln Gly Ile Thr Glu Leu Ser Arg
  40                  45                  50                  55

 tct atc agt gtc gat tta gca gaa agc aaa cgg ctt ggc tgt ctc ctg      426
 Ser Ile Ser Val Asp Leu Ala Glu Ser Lys Arg Leu Gly Cys Leu Leu
                  60                  65                  70

 ctt tcc agt ttc cag ttc tct att cag aaa ctt gaa cct ttc cta agg      474
 Leu Ser Ser Phe Gln Phe Ser Ile Gln Lys Leu Glu Pro Phe Leu Arg
              75                  80                  85

 gac act aag ggc ttc agt ctt gaa agt ttt aga gcc aaa gca tct tct      522
 Asp Thr Lys Gly Phe Ser Leu Glu Ser Phe Arg Ala Lys Ala Ser Ser
          90                  95                 100

 ctt tct gaa gaa ttg aaa cat ttt gca gac gga ctg gaa act gat gga      570
 Leu Ser Glu Glu Leu Lys His Phe Ala Asp Gly Leu Glu Thr Asp Gly
     105                 110                 115

 act cta caa aaa tgt ttt gaa gat tca aat gga aaa gca tca gat ttt      618
 Thr Leu Gln Lys Cys Phe Glu Asp Ser Asn Gly Lys Ala Ser Asp Phe
 120                 125                 130                 135

 tct ttg gaa gca tct gtg gct gag atg aag gaa tac ata aca aag ttt      666
 Ser Leu Glu Ala Ser Val Ala Glu Met Lys Glu Tyr Ile Thr Lys Phe
                 140                 145                 150

 tct tta gaa cgt cag act tgg gat cag ctc ttg ctt cac tac cag cag      714
 Ser Leu Glu Arg Gln Thr Trp Asp Gln Leu Leu Leu His Tyr Gln Gln
             155                 160                 165

 gag gct aaa gag ata ttg tcc aga gga tca act gag gcc aaa att act      762
 Glu Ala Lys Glu Ile Leu Ser Arg Gly Ser Thr Glu Ala Lys Ile Thr
         170                 175                 180

 gag gtc aaa gtg gaa cct atg aca tat ctt ggg tct tct cag aat gaa      810
 Glu Val Lys Val Glu Pro Met Thr Tyr Leu Gly Ser Ser Gln Asn Glu
     185                 190                 195

 gtt ctt aat aca aaa cct gac tac cag aaa ata tta cag aac cag agc      858
 Val Leu Asn Thr Lys Pro Asp Tyr Gln Lys Ile Leu Gln Asn Gln Ser
 200                 205                 210                 215

 aaa gtc ttt gac tgt atg gag ttg gtg atg gat gaa ctg caa gga tca      906
 Lys Val Phe Asp Cys Met Glu Leu Val Met Asp Glu Leu Gln Gly Ser
                 220                 225                 230

 gtg aaa cag ctg cag gcc ttt atg gat gaa agt acc cag tgc ttc cag      954
 Val Lys Gln Leu Gln Ala Phe Met Asp Glu Ser Thr Gln Cys Phe Gln
             235                 240                 245

 aag gtg tca gta cag ctc gga aag aga agc atg caa caa tta gat ccc     1002
 Lys Val Ser Val Gln Leu Gly Lys Arg Ser Met Gln Gln Leu Asp Pro
         250                 255                 260

 tca cca gct cga aaa ctg ttg aag ctt cag cta cag aac cca cct gcc     1050
 Ser Pro Ala Arg Lys Leu Leu Lys Leu Gln Leu Gln Asn Pro Pro Ala
     265                 270                 275

 ata cat gga tct gga tct gga tct tgt cag tga ctttatga gagtttctgc     1101
 Ile His Gly Ser Gly Ser Gly Ser Cys Gln 
 280                 285

 cacaaggtgc ccaagaggag aggaatggga agagtgcccc agcacgtggt gactgcgtga   1161

 tttctgctcg ttgcctttga agataactgg caggactgac tgtagaacac tttgactttt   1221

 ttcaaaaagt gatggaattt gtacatccaa atgaatattg tatagacaat tttcccagga   1281

 atgtgcaaaa tgcttgaaag ttcaaacttc ttttttgaaa tgatcttcag atccagtggc   1341

 ccattctttt atctttatcc tgtgaaggtg tttttcaggt tttgaaacaa tccaaaaatc   1401

 atttaggacc aagtctaagg aaacatttta gtggccaagt tggattccga ttgtaaagga   1461

 atgatactaa ttttctagca tggctctgag tgattttagg tagaaaaagt tggggtggcg   1521

 caagtcccgc gtactagctt ggggatggcg gggttcgggc cgatgagacc cggaaaggga   1581

 ccgttccaaa caagtcgggg ggggccgccc aagggggggg cgggggggac gcacccgagg   1641

 gtaataaa                                                            1649




      <210> 468
      <211> 963
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (707)..(916)

      <400> 468
 aaaactttaa cccaacccaa gtagcctgtg ttaggccact tatggtaaac aattgacagg     60

 tgtatcttaa catccgttaa ccaccagaaa ggattaaatt cacattatta agcaaaatat    120

 tatttcattt tgctcccaaa ggcactgaca acatgagtcc ttgtgattag gcccacctga    180

 tcaaatgtaa aaacatgcat gggatatttg attacgtaac aaccagctaa aactgagagc    240

 acacagcctt cggaaacccc caaggtgtcg aggaggatca gatccagata agagaagatg    300

 attccttcta gtcctgtaaa atttcctgtc atccttagct gctgggttga ttgaaatttg    360

 atctctacat ttcaaaatca aactagtgaa tacagtttgt ctttcaagag aatcagaggc    420

 atcgtaactc ctaccaagtt agtaagtatg agtctaacct tgtttgacat tcaggtcttc    480

 tgctacatta tcttctttga gaaaaattaa ttgattataa aatatgtgct acttcactta    540

 cattattaaa tatgtattaa cgcctctcac cagggcttcc agtgaagtta caatgcccta    600

 gtctgtgaat tagtctggaa acgtgttttt ccttttcgga tgttagagta ccctttgata    660

 aactaaattt tactaagctg aacaactctg acagtctaaa gagcta   atg tgg gtt     715
                                                      Met Trp Val
                                                        1

 acc aaa agg cct gta cct gta aaa caa aat gca ggt gta atg att ata      763
 Thr Lys Arg Pro Val Pro Val Lys Gln Asn Ala Gly Val Met Ile Ile
       5                  10                  15

 cat gtc tat gga tta cct gga cat act ctc att tgg gtt gtt ctt caa      811
 His Val Tyr Gly Leu Pro Gly His Thr Leu Ile Trp Val Val Leu Gln
  20                  25                  30                  35

 aga agc aag cag ccg atc cct gtt ttc ata aag cta ata ctt cag ttg      859
 Arg Ser Lys Gln Pro Ile Pro Val Phe Ile Lys Leu Ile Leu Gln Leu
                  40                  45                  50

 gaa aaa tta aac agg agc aca aag tca ggg ata ggg gtt agc aga aga      907
 Glu Lys Leu Asn Arg Ser Thr Lys Ser Gly Ile Gly Val Ser Arg Arg
              55                  60                  65

 gag aaa tag tgtcaca tcaagggcag gatctcatag ctagggaaca tttcacaaat      963
 Glu Lys 






      <210> 469
      <211> 1103
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (236)..(598)

      <400> 469
 gcacgagtcc agctcctgcg ccgcctgttg ctcgctcctc cgggcggtcg cttcccgccc     60

 ggtgcccagg ggtaggcggc ccgagagcgc gcaggcagcc agcctcccgc cttcgtccct    120

 ccccgtaccg caggagccgg tccgaggggt ccggagcgtc cctgagagcg cggaccccgg    180

 cgagcagccc agtgcacccg ggactgcgcg ccgagacccc cggcgccgcg cggcg atg     238
                                                              Met
                                                                1

 aac gcg acc ttc ctg aac cac agc ggc ttg gag gag gtg gac ggc gtg      286
 Asn Ala Thr Phe Leu Asn His Ser Gly Leu Glu Glu Val Asp Gly Val
               5                  10                  15

 ggc ggc ggc gcc ggg gcc gcc ctg gga aac cgc acc cac ggg ctg ggc      334
 Gly Gly Gly Ala Gly Ala Ala Leu Gly Asn Arg Thr His Gly Leu Gly
          20                  25                  30

 acg tgg ctg ggc tgc tgt cca ggg ggc gca ccg ctg gcc gcc agc gac      382
 Thr Trp Leu Gly Cys Cys Pro Gly Gly Ala Pro Leu Ala Ala Ser Asp
      35                  40                  45

 ggg gtc ccc gcg ggg ctg gcg ccc gac gag cgc agc ctg tgg gtg tcg      430
 Gly Val Pro Ala Gly Leu Ala Pro Asp Glu Arg Ser Leu Trp Val Ser
  50                  55                  60                  65

 cgg gtg gcg cag atc gcc gtg ctc tgc gtg ctg tcg ctt acc gtg gtc      478
 Arg Val Ala Gln Ile Ala Val Leu Cys Val Leu Ser Leu Thr Val Val
                  70                  75                  80

 ttc ggc gtc ttc ttc ctg ggc tgc aac ctg ctc atc aag tcc gag agc      526
 Phe Gly Val Phe Phe Leu Gly Cys Asn Leu Leu Ile Lys Ser Glu Ser
              85                  90                  95

 atg atc aac ttt ctg gtg cag gag cgc cgg ccc tcc aag gac gtg ggc      574
 Met Ile Asn Phe Leu Val Gln Glu Arg Arg Pro Ser Lys Asp Val Gly
         100                 105                 110

 gca gcc atc ctg ggg ctg tac tga gcgccatctg ggtccgccct cgccagcgct     628
 Ala Ala Ile Leu Gly Leu Tyr 
     115                 120

 gctgcaagaa ggaccccgga gacccggacc ctcgccccgc tctctgcgct ctgccgccgc    688

 ctccgggcgg gcagctacgt gcctggggcg cccgggcggg gacgcggcga gactgtcggc    748

 gggggcgcgg gaagggactt ggacgcccgg ctctgtcctg tgtgcgctgc agcgttgcgg    808

 ggtgggagaa tgtggggtga gggttcttac cagttttttt tttgtttgtt tgttttttaa    868

 gacgttcggg gcagggtggg agtgggtatg gagatgcaat ttgggactgc ggtcgctcgc    928

 gtgggagttt tgtgtgtacg ttggtgcggg tgggttcgga acacggtgcg agtgggtgaa    988

 gatgtgaagc gtcagagtcg ctgagcttgt tggcctgatc ttgcgtttgg aaagaaatct   1048

 tgtaataaaa ctgcagccgt agggcttcag gcagcttccc accaaaaaaa aaaaa        1103




      <210> 470
      <211> 659
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (183)..(470)

      <400> 470
 aggtttctct atcatttctg acttgttacc agtgatgtct ttcaatcccg actgtaaatc     60

 cagagtcttc tgagaagggt aaggcgtcca gagctatggc tcactctttc ctctcacctt    120

 gcatgctgtg ctcaccagag aaatggatgg atttgtggat ggatcaccca attaattaat    180

 ta   atg gat cag act cta tca cct tcc tct ccc acc tgt gag tca gtc     227
      Met Asp Gln Thr Leu Ser Pro Ser Ser Pro Thr Cys Glu Ser Val
        1               5                  10                  15

 cag aca ttc cag aat ttt ata gct cca gca cca tgc ccc aga gaa aaa      275
 Gln Thr Phe Gln Asn Phe Ile Ala Pro Ala Pro Cys Pro Arg Glu Lys
                  20                  25                  30

 caa aaa aca acc tcc tgg gcc ttg aac cat cag cca ctt ttc aaa gaa      323
 Gln Lys Thr Thr Ser Trp Ala Leu Asn His Gln Pro Leu Phe Lys Glu
              35                  40                  45

 agt caa gac tcc gtc aac att ttt ttc ttc cct ccc aaa att aaa atg      371
 Ser Gln Asp Ser Val Asn Ile Phe Phe Phe Pro Pro Lys Ile Lys Met
          50                  55                  60

 tgc ctc cag tat aac ttg tta tca aaa ata gaa gca ttt tat cta tct      419
 Cys Leu Gln Tyr Asn Leu Leu Ser Lys Ile Glu Ala Phe Tyr Leu Ser
      65                  70                  75

 tta ttg cag aac aga gat tac atg gag aca ttc aat ttg gag tca att      467
 Leu Leu Gln Asn Arg Asp Tyr Met Glu Thr Phe Asn Leu Glu Ser Ile
  80                  85                  90                  95

 taa attt caattgtctg tgaaatctaa atcaataggg tatagttcaa tgacgcttta      524
 


 ataaaacagg acataacaga gaaatcatta ggaattacat atgataagag attggagcag    584

 agcctttgta atggtggaag gaacattaga aaattacccc caagcattcg caagtaaacc    644

 aactacctcc ttccc                                                     659




      <210> 471
      <211> 772
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (471)..(725)

      <220>
      <221> misc_feature
      <222> (1)...(772)
      <223> n = a,t,c or g

      <400> 471
 gtagacgcgg gggcgnggtt tctgcaaagg ccgtattagt ggggaacgca cggggtttcc     60

 cccgcccccg ggtgttaaac cgccgccccg ggcccacgta aatttacccc cccttaaagg    120

 gattaagcgt ccggcgcctt attaaaagtt tttttttttt tttttctttg gctgctcttt    180

 gatcacccct taggttcatt tctcatatct tctatcaact cccctaaccc ctgctttcct    240

 gggccaccca gtttacctcc ctacttccaa gtcttattag tcttgcatca gaaacacgaa    300

 gccctgctgt cataacaaag aatgtgtgca tttgtgagga ccactttaca aactgattta    360

 gcagaaagaa ggcaccttgc tgcatactaa taatattgct ttaataatgt tttcttgaag    420

 atggctgcac ccaggcgagt tgagcagagg aggctgcagt gagccccagc   atg gct     476
                                                          Met Ala
                                                            1

 gag gaa gaa cag gga agc acc agc tgc cga gag agg agg agt ata agg      524
 Glu Glu Glu Gln Gly Ser Thr Ser Cys Arg Glu Arg Arg Ser Ile Arg
           5                  10                  15

 ttc aag atg aaa aat cat tca ccg gat gac act atc aag gaa aat gtg      572
 Phe Lys Met Lys Asn His Ser Pro Asp Asp Thr Ile Lys Glu Asn Val
      20                  25                  30

 aca ata tcc aat atc agg acc aga aaa att aac caa ctt cca gag aca      620
 Thr Ile Ser Asn Ile Arg Thr Arg Lys Ile Asn Gln Leu Pro Glu Thr
  35                  40                  45                  50

 gag agg aat ctg ctt gaa cat gga ttg atg tat atc aga ctt aat gct      668
 Glu Arg Asn Leu Leu Glu His Gly Leu Met Tyr Ile Arg Leu Asn Ala
                  55                  60                  65

 gct ttc tgt agc cta gta gca cac agt ctt ttt gga ttc atc tta aaa      716
 Ala Phe Cys Ser Leu Val Ala His Ser Leu Phe Gly Phe Ile Leu Lys
              70                  75                  80

 gcg aca tag gcttggc cgggcgtggt ggctcagcca agtaggttat ttggtagtga      772
 Ala Thr 






      <210> 472
      <211> 855
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (227)..(499)

      <400> 472
 ggttaaaaaa agggagaagg actcatcaac acattgctgc ctgcaaaccc agggaaagac     60

 caccttacac cacattatat ggcatctgta aatcaacatg ggccagcggg agacaccaag    120

 gccctaccag gagctgctct ttgatcacga ggttcacgct gcatcttttc gggaaggtta    180

 aaaaataata aatgaccacc aggatcacag aaggaaagag ctcgtg   atg tcc atg     235
                                                      Met Ser Met
                                                        1

 gaa ttc acg cag atc aca tcc agg aat ctt tgg aac aaa aaa ttc aca      283
 Glu Phe Thr Gln Ile Thr Ser Arg Asn Leu Trp Asn Lys Lys Phe Thr
       5                  10                  15

 aca cca tgg cct cat aca aaa atg ctg ggc tgc agg aaa cct gag gca      331
 Thr Pro Trp Pro His Thr Lys Met Leu Gly Cys Arg Lys Pro Glu Ala
  20                  25                  30                  35

 gag agc tcc atc atc aca gtg aag tcc ccg cct tca gca gat ccc acc      379
 Glu Ser Ser Ile Ile Thr Val Lys Ser Pro Pro Ser Ala Asp Pro Thr
                  40                  45                  50

 aac agc cac agt gct tcc cat cac ctg aaa aaa act cat gta tca aac      427
 Asn Ser His Ser Ala Ser His His Leu Lys Lys Thr His Val Ser Asn
              55                  60                  65

 tat tac act tct tca gaa tat tgg aaa atg gtg cat agt tca tat gtt      475
 Tyr Tyr Thr Ser Ser Glu Tyr Trp Lys Met Val His Ser Ser Tyr Val
          70                  75                  80

 ctc att tgt tta tct tgt gtc taa agtgtcttgt cattccaggc cactctattt     529
 Leu Ile Cys Leu Ser Cys Val 
      85                  90

 cttgtgtatt aataaaaagt ttgaggtata gagaaacaca tgaacaacac tgaagccccc    589

 cgaggagctg gccaaccccg aaaaccagaa aaaaagagga ctacattctg aagagagatg    649

 aacgtgcctg actttgactt ccctcccgaa ttctatgagc atgccaaggc tctgtgggag    709

 gatgaaggag tgcgtgcctg ctacaaacgc tccaacgagg accagctgat tgactgtgcc    769

 caggacttcc tggacaagat cgacgtgatc aagcaggctg actatgtgcc gagcgatcag    829

 gacctgcttc gctgccgtgt cctgac                                         855




      <210> 473
      <211> 1963
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (251)..(1510)

      <400> 473
 ccactctctt gcccacgtac cctctgccag tgtcctctcc ccagtatctg agctgtctct     60

 ggggcccggg ccgggcagtg aggtgctgac cagtcgtatc aggcagggcc tgctgcatgc    120

 tggagaggat ttggggtcag tttgggtcag aagtggagga aactcccccc agtcaagcca    180

 ggatgcgagg tctcggccga gggtggggcc ctgcaccagc cctgcctgac ggctcctccc    240

 ccaggtggag   atg tac aag cat gtc ttc cag cgg ccc ccg gac cga cac     289
              Met Tyr Lys His Val Phe Gln Arg Pro Pro Asp Arg His
                1               5                  10

 tca gac ttc tcc cgc ctg gcg agg gtg ctg acg ggc aac gcc att gcc      337
 Ser Asp Phe Ser Arg Leu Ala Arg Val Leu Thr Gly Asn Ala Ile Ala
      15                  20                  25

 ctg gtg ctt ggg gga ggg gga gca aga ggc tgt gcc cag gtg ggc gtt      385
 Leu Val Leu Gly Gly Gly Gly Ala Arg Gly Cys Ala Gln Val Gly Val
  30                  35                  40                  45

 ctc aag gcc ttg gcg gag tgc ggc atc cct gtg gac atg gtg gga ggc      433
 Leu Lys Ala Leu Ala Glu Cys Gly Ile Pro Val Asp Met Val Gly Gly
                  50                  55                  60

 acg tcc atc ggg gcc ttc gtg ggt gcc ctg tac tct gag gag cgg aac      481
 Thr Ser Ile Gly Ala Phe Val Gly Ala Leu Tyr Ser Glu Glu Arg Asn
              65                  70                  75

 tac agc cag atg cgg atc cgg gcc aag cag tgg gcc gag ggc atg acg      529
 Tyr Ser Gln Met Arg Ile Arg Ala Lys Gln Trp Ala Glu Gly Met Thr
          80                  85                  90

 tcc ttg atg aag gcc gcg ctg gac ctc acc tac ccc atc acg tcc atg      577
 Ser Leu Met Lys Ala Ala Leu Asp Leu Thr Tyr Pro Ile Thr Ser Met
      95                 100                 105

 ttc tcc gga gcc ggc ttc aac agc agc atc ttc agc gtc ttc aag gac      625
 Phe Ser Gly Ala Gly Phe Asn Ser Ser Ile Phe Ser Val Phe Lys Asp
 110                 115                 120                 125

 cag cag atc gag gac ctg tgg att cct tat ttc gcc atc acc acc gac      673
 Gln Gln Ile Glu Asp Leu Trp Ile Pro Tyr Phe Ala Ile Thr Thr Asp
                 130                 135                 140

 atc aca gcc tcg gcc atg cgg gtc cac acc gac ggc tcc ctg tgg cgg      721
 Ile Thr Ala Ser Ala Met Arg Val His Thr Asp Gly Ser Leu Trp Arg
             145                 150                 155

 tac gtg cgt gcc agc atg tcc ctg tcc ggt tac atg ccc cct ctc tgt      769
 Tyr Val Arg Ala Ser Met Ser Leu Ser Gly Tyr Met Pro Pro Leu Cys
         160                 165                 170

 gac ccg aag gac gga cac ctg ctg atg gac ggg ggc tac atc aac aac      817
 Asp Pro Lys Asp Gly His Leu Leu Met Asp Gly Gly Tyr Ile Asn Asn
     175                 180                 185

 ctc cca gcg gat gtg gcc cgg tcc atg ggg gca aaa gtg gtg atc gcc      865
 Leu Pro Ala Asp Val Ala Arg Ser Met Gly Ala Lys Val Val Ile Ala
 190                 195                 200                 205

 att gac gtg ggc agc cga gat gag acg gac ctc acc aac tat ggg gat      913
 Ile Asp Val Gly Ser Arg Asp Glu Thr Asp Leu Thr Asn Tyr Gly Asp
                 210                 215                 220

 gcg ctg tct ggg tgg tgg ctg ctg tgg aaa cgc tgg aac ccc ttg gcc      961
 Ala Leu Ser Gly Trp Trp Leu Leu Trp Lys Arg Trp Asn Pro Leu Ala
             225                 230                 235

 acg aaa gtc aag gtg ttg aac atg gca gag att cag acg cgc ctg gcc     1009
 Thr Lys Val Lys Val Leu Asn Met Ala Glu Ile Gln Thr Arg Leu Ala
         240                 245                 250

 tac gtg tgt tgc gtg cgg cag ctg gag gtg gtg aag agc agt gac tac     1057
 Tyr Val Cys Cys Val Arg Gln Leu Glu Val Val Lys Ser Ser Asp Tyr
     255                 260                 265

 tgc gag tac ctg cgc ccc ccc atc gac agc tac agc acc ctg gac ttc     1105
 Cys Glu Tyr Leu Arg Pro Pro Ile Asp Ser Tyr Ser Thr Leu Asp Phe
 270                 275                 280                 285

 ggc aag ttc aac gag atc tgc gaa gtg ggc tac cag cac ggg cgc acg     1153
 Gly Lys Phe Asn Glu Ile Cys Glu Val Gly Tyr Gln His Gly Arg Thr
                 290                 295                 300

 gtg ttt gac atc tgg ggc cgc agc ggc gtg ctg gag aag atg ctg cgc     1201
 Val Phe Asp Ile Trp Gly Arg Ser Gly Val Leu Glu Lys Met Leu Arg
             305                 310                 315

 gac cag cag ggg ccg agc aag aag ccc gcg agt gcg gtc ctc acc tgt     1249
 Asp Gln Gln Gly Pro Ser Lys Lys Pro Ala Ser Ala Val Leu Thr Cys
         320                 325                 330

 ccc aac gcc tcc ttc acg gac ctt gcc gaa att gtg tct cgc att gag     1297
 Pro Asn Ala Ser Phe Thr Asp Leu Ala Glu Ile Val Ser Arg Ile Glu
     335                 340                 345

 ccc gcc aag ccc gcc atg gtg gat gac gaa tct gac tac cag acg gag     1345
 Pro Ala Lys Pro Ala Met Val Asp Asp Glu Ser Asp Tyr Gln Thr Glu
 350                 355                 360                 365

 tac gag gag gag ctg ctg gac gtc ccc agg gat gca tac gca gac ttc     1393
 Tyr Glu Glu Glu Leu Leu Asp Val Pro Arg Asp Ala Tyr Ala Asp Phe
                 370                 375                 380

 cag agc acc tca gcc cag cag ggc tca gac ttg gag gac gag tcc tca     1441
 Gln Ser Thr Ser Ala Gln Gln Gly Ser Asp Leu Glu Asp Glu Ser Ser
             385                 390                 395

 ctg cgg cat cga cac ccc agt ctg gct ttc cca aaa ctg tct gag ggc     1489
 Leu Arg His Arg His Pro Ser Leu Ala Phe Pro Lys Leu Ser Glu Gly
         400                 405                 410

 tcc tct gac cag gac ggg tag ag gcctctgcta aagagcccgg atgcagcgtc     1542
 Ser Ser Asp Gln Asp Gly 
     415

 ttccgtggga ctgtccccaa ggctgaggct cctgccaagt cctaggggcc tctgtacctg   1602

 ccctgctgga agccctgact tccccggggc cccaggctgt gttagggttc tctgggcctc   1662

 ttctttgtac cagcagccct gcatacaggg ccctgtgagc ccccctgcag tcctgtgagg   1722

 cccctgaagc tctgtgaggc ccctgaagct ctgtgaaccc cctgcagccc tgtgaggccc   1782

 cccgaagccc tgtgaggccc cccgaagccc tgtgaaccac ctgctgccct gtgaggcccc   1842

 caaagccctg tgaactgcct gctgtcctgt gaactgcctg ctgccctgtg aggtgtggga   1902

 gccctgatgc tgccgtgtga tgtttcaata aaggtggatc tcactgttaa aaaaaaaaaa   1962

 a                                                                   1963




      <210> 474
      <211> 621
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (314)..(604)

      <400> 474
 tttttgttta atttatttaa gaccacctcc ttacaacttc cagagagaaa atacaaaaca     60

 agaaacagac ttggtttcaa atgcataacc aggtgctgga gtttaaagca ttactgataa    120

 cattgttaca gaagaatggc agcttactcc agggcacttc agtattcctg aggaataaac    180

 atgatttctc ttgtcctccc gctgggatgt tctcaggtga agtcactgct cctgctcttt    240

 gacatatttt ccatgtagaa gatatggagc ctggaaatca tgctgacagt tggaataagc    300

 cattcctaat ccc   atg cca gaa ccg aag gct aat ggc cac att ctt ctt     349
                  Met Pro Glu Pro Lys Ala Asn Gly His Ile Leu Leu
                    1               5                  10

 tta aag aag gta agt gag aaa aca att cct aat cca aaa cca gta ccc      397
 Leu Lys Lys Val Ser Glu Lys Thr Ile Pro Asn Pro Lys Pro Val Pro
          15                  20                  25

 ttc ctg tgg cta tct gga cta gac aga ggc tgg aac atc tgc agg gat      445
 Phe Leu Trp Leu Ser Gly Leu Asp Arg Gly Trp Asn Ile Cys Arg Asp
      30                  35                  40

 ttc tcg ggt gga cat caa tta cca gga ttc tat ctt cac gac cgc atc      493
 Phe Ser Gly Gly His Gln Leu Pro Gly Phe Tyr Leu His Asp Arg Ile
  45                  50                  55                  60

 cgc cag aca ccg gtc cca ctt cct gcc gag ctc cga ctc aga cat gtt      541
 Arg Gln Thr Pro Val Pro Leu Pro Ala Glu Leu Arg Leu Arg His Val
                  65                  70                  75

 ccc cac ccg cgc ctc cag ctt tcc tct cgc cgc ccc cgc gca cca acc      589
 Pro His Pro Arg Leu Gln Leu Ser Ser Arg Arg Pro Arg Ala Pro Thr
              80                  85                  90

 cgg cct cgc acc tag cctaagttgt gtcttta                               621
 Arg Pro Arg Thr 
          95





      <210> 475
      <211> 770
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(491)

      <400> 475
 aagtc    atg gcg gcg ctg tgt cgg acc cgt gct gtg gct gcc gag agc      47
          Met Ala Ala Leu Cys Arg Thr Arg Ala Val Ala Ala Glu Ser
            1               5                  10

 cat ttt ctg cga gtg ttt ctc ttc ttc agg ccc ttt cgg ggt gta ggc       95
 His Phe Leu Arg Val Phe Leu Phe Phe Arg Pro Phe Arg Gly Val Gly
  15                  20                  25                  30

 act gag agt gga tcc gaa agt ggt agt tcc aat gcc aag gag cct aag      143
 Thr Glu Ser Gly Ser Glu Ser Gly Ser Ser Asn Ala Lys Glu Pro Lys
                  35                  40                  45

 acg cgc gca ggc ggt ttc gcg agc gcg ttg gag cgg cac tcg gag ctt      191
 Thr Arg Ala Gly Gly Phe Ala Ser Ala Leu Glu Arg His Ser Glu Leu
              50                  55                  60

 cta cag aag atg gga cct gca aag gat aaa ctg gtc att gga cgg atc      239
 Leu Gln Lys Met Gly Pro Ala Lys Asp Lys Leu Val Ile Gly Arg Ile
          65                  70                  75

 ttt cac att gtg gag aat gat ctg tac ata gat ttt ggt gga aag ttt      287
 Phe His Ile Val Glu Asn Asp Leu Tyr Ile Asp Phe Gly Gly Lys Phe
      80                  85                  90

 cat tgt gta tgt aga aga cca gaa gtg gat gga gag aaa tac cag aaa      335
 His Cys Val Cys Arg Arg Pro Glu Val Asp Gly Glu Lys Tyr Gln Lys
  95                 100                 105                 110

 gga acc agg gtc cgg ttg cgg cta tta gat ctt gaa ctt acg tct agg      383
 Gly Thr Arg Val Arg Leu Arg Leu Leu Asp Leu Glu Leu Thr Ser Arg
                 115                 120                 125

 ttc ctg gga gca aca aca gat aca act gta cta gag gct aat gca gtt      431
 Phe Leu Gly Ala Thr Thr Asp Thr Thr Val Leu Glu Ala Asn Ala Val
             130                 135                 140

 ctc ttg gga atc cag gag agt aaa gac tca aga tcg aaa gaa gaa cat      479
 Leu Leu Gly Ile Gln Glu Ser Lys Asp Ser Arg Ser Lys Glu Glu His
         145                 150                 155

 cat gaa aaa taa atg aactttgctt agtggattga ctcctttgct gaagtcagtt      534
 His Glu Lys 
     160

 attcatcaag aatgcaatta gactaattgt gaataaatga ttgaatgaag atataataaa    594

 taaaagctat aattatagat aactcttatt agaattttct ttagcaatat tcccaccccc    654

 caccccttgt tttgctctta atgttttttt cctttggtgg ggatagtata cactgtacta    714

 agaaattgtc attcaataaa tacgttttga gtgctgtcta aaaaaaaaaa aaaaaa        770




      <210> 476
      <211> 1722
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (448)..(1473)

      <400> 476
 gccaagggcg agccgtcagt ccccgggtgc gagtccctgc tgtcttccac acccttcctc     60

 cctccaggct cctttcctac atccttcccg cgcccccacg gttgcggacc gagcgagaac    120

 ccccttaagc aggtgtgggg ggcgtgcggg gtggcacgag acaaaagggg cacgggggta    180

 agcccgccat ggcctcccgg agcctggggg gcctgagcgg gatccgcggc ggtggcggcg    240

 gaggcggcaa gaaaagcctg agcgcccgca atgctgcggt ggagaggagg aacctgatca    300

 ccgtgtgcag gttttctgtg aagaccctga ttgatcggtc ttgctttgag acaattgatg    360

 attcttctcc tgaatttaac aattttgcag ctattttgga acagatttta agccaccggc    420

 taaaaggtca agtaacctgg tttggtt    atg aaa gtc ctc gta gct tct ggg     471
                                  Met Lys Val Leu Val Ala Ser Gly
                                    1               5

 act ata tca gag tgg ctt gcc gga aag ttt cac aga att gta tct gca      519
 Thr Ile Ser Glu Trp Leu Ala Gly Lys Phe His Arg Ile Val Ser Ala
      10                  15                  20

 gca ttg aaa ata tgg aaa atg tca gtt ctt cta gag cta agg aga ttt      567
 Ala Leu Lys Ile Trp Lys Met Ser Val Leu Leu Glu Leu Arg Arg Phe
  25                  30                  35                  40

 tat gaa gat gga gca att gtc ttg ggt gaa gaa gca aat atg ctt gct      615
 Tyr Glu Asp Gly Ala Ile Val Leu Gly Glu Glu Ala Asn Met Leu Ala
                  45                  50                  55

 ggc atg ctt cta gga ctc aat gct att gat ttc agt ttc tgc cta aag      663
 Gly Met Leu Leu Gly Leu Asn Ala Ile Asp Phe Ser Phe Cys Leu Lys
              60                  65                  70

 gga gag ggg ctg gat ggc agt ttt cct gct gta ata gac tat aca cca      711
 Gly Glu Gly Leu Asp Gly Ser Phe Pro Ala Val Ile Asp Tyr Thr Pro
          75                  80                  85

 tat ttg aag tat atc caa agt tct gat agt atc agc agt gat gag gag      759
 Tyr Leu Lys Tyr Ile Gln Ser Ser Asp Ser Ile Ser Ser Asp Glu Glu
      90                  95                 100

 gag cta agg act ttg gga agc agt ggt agc gaa agc agt act cca gag      807
 Glu Leu Arg Thr Leu Gly Ser Ser Gly Ser Glu Ser Ser Thr Pro Glu
 105                 110                 115                 120

 aat gtc gga cct cct ttc ctc atg gat gag aac agt tgg ttc aac aag      855
 Asn Val Gly Pro Pro Phe Leu Met Asp Glu Asn Ser Trp Phe Asn Lys
                 125                 130                 135

 tgt aag aga gtt aaa caa aag tat cag ctt acc ctg gaa cag aag ggt      903
 Cys Lys Arg Val Lys Gln Lys Tyr Gln Leu Thr Leu Glu Gln Lys Gly
             140                 145                 150

 tac ctt gaa gaa ctc tta cga ctt cga gag aac caa cta tct gaa tct      951
 Tyr Leu Glu Glu Leu Leu Arg Leu Arg Glu Asn Gln Leu Ser Glu Ser
         155                 160                 165

 gtc tcc cag aat aaa ata cta ctt caa agg att gaa gat tcc gat ctg      999
 Val Ser Gln Asn Lys Ile Leu Leu Gln Arg Ile Glu Asp Ser Asp Leu
     170                 175                 180

 gct cat aaa ctg gag aag gaa caa tta gaa tat ata att gtg gag ctt     1047
 Ala His Lys Leu Glu Lys Glu Gln Leu Glu Tyr Ile Ile Val Glu Leu
 185                 190                 195                 200

 caa gat cag ctg act gtg cta aag aat aat gat tta aga tcg aga caa     1095
 Gln Asp Gln Leu Thr Val Leu Lys Asn Asn Asp Leu Arg Ser Arg Gln
                 205                 210                 215

 gag tta act gcc cat ctc acc aac cag tgg cct tct cca gga gct ctg     1143
 Glu Leu Thr Ala His Leu Thr Asn Gln Trp Pro Ser Pro Gly Ala Leu
             220                 225                 230

 gat gtc aat gct gtt gcc ttg gat acg ttg ctt tac cga aaa cac aat     1191
 Asp Val Asn Ala Val Ala Leu Asp Thr Leu Leu Tyr Arg Lys His Asn
         235                 240                 245

 aaa cag ggg tat gag aaa agt tat caa agt ctt gac cag tta tca gca     1239
 Lys Gln Gly Tyr Glu Lys Ser Tyr Gln Ser Leu Asp Gln Leu Ser Ala
     250                 255                 260

 gaa gtt agc ctt tct cag act tca cta gat cca ggc cag tca caa gaa     1287
 Glu Val Ser Leu Ser Gln Thr Ser Leu Asp Pro Gly Gln Ser Gln Glu
 265                 270                 275                 280

 gga gat gga aaa caa gac aca tta aat gta atg agt gaa ggt aag gaa     1335
 Gly Asp Gly Lys Gln Asp Thr Leu Asn Val Met Ser Glu Gly Lys Glu
                 285                 290                 295

 gat act ccc tca tta ctt ggc ctc tgt gga tct cta acg tca gtg gca     1383
 Asp Thr Pro Ser Leu Leu Gly Leu Cys Gly Ser Leu Thr Ser Val Ala
             300                 305                 310

 agt tac aag ttt tta aca agc tta aaa ttt aat gac tac ctt gca agt     1431
 Ser Tyr Lys Phe Leu Thr Ser Leu Lys Phe Asn Asp Tyr Leu Ala Ser
         315                 320                 325

 cct aca aca gag atg aca agt cca ggc cta act cca tcc tga aaatttt     1480
 Pro Thr Thr Glu Met Thr Ser Pro Gly Leu Thr Pro Ser 
     330                 335                 340

 tgtgtaaaag ccaaaacttt ttatgttgta aatgtttaat ttacatgttt gactgctggg   1540

 aagacctttg aaattttata ttggtttggg acaagtttga aattttattg gttggagaga   1600

 atcccctcca gataagagat tttgagtgaa aaacataatg atcctgccct ttttcatttt   1660

 taaaattttt acatttgtca ttgagaaagt tcaaaatgga ataggcttta aaaaaaaaaa   1720

 aa                                                                  1722




      <210> 477
      <211> 963
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (275)..(694)

      <400> 477
 acctggggaa aggagtcgac ctttgagacc tgcttattca tggctgtttc acggatgtcg     60

 aagtggaggc tcagcagggt tggaggttcc cggagtctcc cagctgaaat ggaagtgctt    120

 ggtgaggttt ggtgtgtccg agccgaagag cagccaatga caggcctggg gatcgtctgg    180

 cacagcccac ttcttgacaa ggccttggaa acttggtctc tgcagcagca accggatttc    240

 agcctgggcc tcggacacct cggcctgggt acgg    atg cga ctt gga tgc agt     292
                                          Met Arg Leu Gly Cys Ser
                                            1               5

 cct tcc ctg gca gtg gag ggg atg ccc agg ctg gca cag gag tct cgg      340
 Pro Ser Leu Ala Val Glu Gly Met Pro Arg Leu Ala Gln Glu Ser Arg
              10                  15                  20

 gtc ctc tcc ggc tct acc cca atc tgc tgt gtg att ttg ggc cca ggc      388
 Val Leu Ser Gly Ser Thr Pro Ile Cys Cys Val Ile Leu Gly Pro Gly
          25                  30                  35

 agg gac ccc tct ggg ctc tgt tac tgg aga aaa ggc aaa tgg ctg gta      436
 Arg Asp Pro Ser Gly Leu Cys Tyr Trp Arg Lys Gly Lys Trp Leu Val
      40                  45                  50

 cgg gtg ggt ccc cag ccc tcc ttg cct gga ggt ctg cga gtt gga ggg      484
 Arg Val Gly Pro Gln Pro Ser Leu Pro Gly Gly Leu Arg Val Gly Gly
  55                  60                  65                  70

 ctc tgg ggt aaa gcc aga gcc ggg ccc ggg gag agc ctg ggc tca tct      532
 Leu Trp Gly Lys Ala Arg Ala Gly Pro Gly Glu Ser Leu Gly Ser Ser
                  75                  80                  85

 ctg gtg aac agg gta ccc tct agc caa agc agg ggc aag gcg agg cac      580
 Leu Val Asn Arg Val Pro Ser Ser Gln Ser Arg Gly Lys Ala Arg His
              90                  95                 100

 atg ccc ctc ata tgg gag ctg ggg ctg acc ccc tct cct agc cct gca      628
 Met Pro Leu Ile Trp Glu Leu Gly Leu Thr Pro Ser Pro Ser Pro Ala
         105                 110                 115

 cac ctt gag cac gtg gcc ttg gcc cat ctg ccc tgt ggg tgg aca ctt      676
 His Leu Glu His Val Ala Leu Ala His Leu Pro Cys Gly Trp Thr Leu
     120                 125                 130

 tcc agc cct ggg tcc tga actcta ccaatcagca ggaacctaga ctcctgaggg      730
 Ser Ser Pro Gly Ser 
 135

 gtgcagcctg gatgggaggt cagggaactg ggttcctgag cgcatctctg tgccattcat    790

 ctctccattg gtttcccaaa tgtggactga gcacacactg tgagtcaggc ctgagctagg    850

 ttctagggat gctactgtca acaagacaga tgaaggttcc tgccctcatg gaggggaggg    910

 agacaataag caaagaaata aatgcatgat gtaatgtcaa aaaaaaaaaa aaa           963




      <210> 478
      <211> 2484
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (481)..(2484)

      <400> 478
 actcaggatg gctacttttc tcatcggccg aaagagaaag tgcgaacaga cagcaacaac     60

 gagaactctg tccccaaaga ctttgagaat gtggacaaca gcaacttcgc acccaggact    120

 caaaagcaga agcaccagcc tgagttggcg aagaagccac cgagtagaca gaaggagctt    180

 ttgaaaagga agctggaaca gcaggagaaa ggaaaaggac atacattccc tgggaaaggc    240

 cccggtgagg tgctgcctcc cggggacaga gccgcagcca acagcagcca cgggaaggat    300

 gtgtccagac cgcctcatgc caggaaaact gggggcagct cccccgagac caagtatgac    360

 cagcccccta agtgtgacat ctcaggcaag gaggccatct ctgccctgtc ccgtgctaag    420

 tccaagcact gccgccagga gattggggag acttactgcc gccacaagtt agggctgctg    480
                                                                 
 atg cct gag aag gtg act cgg ttc tgc ccc ctc gag ggt aaa gcc aac      528
 Met Pro Glu Lys Val Thr Arg Phe Cys Pro Leu Glu Gly Lys Ala Asn
   1               5                  10                  15

 aag aac gtg cag tgg gac gag gac tcc gtg gag tac atg cca gcc aac      576
 Lys Asn Val Gln Trp Asp Glu Asp Ser Val Glu Tyr Met Pro Ala Asn
              20                  25                  30

 ccg gtc aga atc gcc ttt gtc ctg gtg gtc cac ggc cgt gcc tct cgg      624
 Pro Val Arg Ile Ala Phe Val Leu Val Val His Gly Arg Ala Ser Arg
          35                  40                  45

 cag ttg cag cgc atg ttc aag gcc atc tac cac aaa gac cac ttc tac      672
 Gln Leu Gln Arg Met Phe Lys Ala Ile Tyr His Lys Asp His Phe Tyr
      50                  55                  60

 tac atc cac gtg gac aag cgc tct aat tgc ctg cat cgg caa gtg ctc      720
 Tyr Ile His Val Asp Lys Arg Ser Asn Cys Leu His Arg Gln Val Leu
  65                  70                  75                  80

 cag gtc tcc agg cag tac agc aat gtc cgc gtc acc ccc tgg aga atg      768
 Gln Val Ser Arg Gln Tyr Ser Asn Val Arg Val Thr Pro Trp Arg Met
                  85                  90                  95

 gcc acc atc tgg gga gga gcc agc ctc ctg tcc acc tac ctg cag agc      816
 Ala Thr Ile Trp Gly Gly Ala Ser Leu Leu Ser Thr Tyr Leu Gln Ser
             100                 105                 110

 atg cgg gac ctc ctg gag atg acc gac tgg ccc tgg gac ttc ttc atc      864
 Met Arg Asp Leu Leu Glu Met Thr Asp Trp Pro Trp Asp Phe Phe Ile
         115                 120                 125

 aac ctg agt gcg gcc gac tac ccc atc agg aca aat gac cag ttg gtg      912
 Asn Leu Ser Ala Ala Asp Tyr Pro Ile Arg Thr Asn Asp Gln Leu Val
     130                 135                 140

 gcg ttt ctc tcc cga tac cga gat atg aat ttc ttg aag tca cac ggc      960
 Ala Phe Leu Ser Arg Tyr Arg Asp Met Asn Phe Leu Lys Ser His Gly
 145                 150                 155                 160

 cgg gac aat gca agg ttc att cgg aag cag ggc ctg gat cgg ctc ttc     1008
 Arg Asp Asn Ala Arg Phe Ile Arg Lys Gln Gly Leu Asp Arg Leu Phe
                 165                 170                 175

 ctg gag tgc gac gct cac atg tgg cgc ctg gga gat cgg cgg atc cca     1056
 Leu Glu Cys Asp Ala His Met Trp Arg Leu Gly Asp Arg Arg Ile Pro
             180                 185                 190

 gag ggc att gcc gtg gat ggc ggt tcg gac tgg ttc ctg ctg aac cgg     1104
 Glu Gly Ile Ala Val Asp Gly Gly Ser Asp Trp Phe Leu Leu Asn Arg
         195                 200                 205

 agg ttt gta gaa tat gtg acc ttc tcc aca gac gat ctg gtg acc aag     1152
 Arg Phe Val Glu Tyr Val Thr Phe Ser Thr Asp Asp Leu Val Thr Lys
     210                 215                 220

 atg aaa cag ttc tac tcc tac acc ctg ctt cct gct gag tcc ttc ttc     1200
 Met Lys Gln Phe Tyr Ser Tyr Thr Leu Leu Pro Ala Glu Ser Phe Phe
 225                 230                 235                 240

 cat acg gtc ctg gag aac agc ccc cac tgc gac acc atg gtg gac aac     1248
 His Thr Val Leu Glu Asn Ser Pro His Cys Asp Thr Met Val Asp Asn
                 245                 250                 255

 aac ctg cgc atc acc aac tgg aat cgc aag ctg ggc tgc aag tgc cag     1296
 Asn Leu Arg Ile Thr Asn Trp Asn Arg Lys Leu Gly Cys Lys Cys Gln
             260                 265                 270

 tac aag cac atc gtg gac tgg tgc ggc tgc tcc ccc aat gac ttc aag     1344
 Tyr Lys His Ile Val Asp Trp Cys Gly Cys Ser Pro Asn Asp Phe Lys
         275                 280                 285

 ccg cag gac ttc cac cgc ttc cag cag aca gcc cgg cct acc ttc ttt     1392
 Pro Gln Asp Phe His Arg Phe Gln Gln Thr Ala Arg Pro Thr Phe Phe
     290                 295                 300

 gcc cgc aag ttt gaa gcc gtg gtg aat cag gaa atc att ggg cag ctg     1440
 Ala Arg Lys Phe Glu Ala Val Val Asn Gln Glu Ile Ile Gly Gln Leu
 305                 310                 315                 320

 gac tat tac ctg tac ggg aac tac cct gca ggt acc ccg ggc ctg cgc     1488
 Asp Tyr Tyr Leu Tyr Gly Asn Tyr Pro Ala Gly Thr Pro Gly Leu Arg
                 325                 330                 335

 tcc tac tgg gag aat gtc tac gat gag cct gac ggc atc cac agc ctg     1536
 Ser Tyr Trp Glu Asn Val Tyr Asp Glu Pro Asp Gly Ile His Ser Leu
             340                 345                 350

 agc gac gtg aca ctc acc ttg tac cac tcc ttt gcc cgc ctg ggt ctt     1584
 Ser Asp Val Thr Leu Thr Leu Tyr His Ser Phe Ala Arg Leu Gly Leu
         355                 360                 365

 cga cgg gcc gag acg tcc ctg cac acg gat ggg gag aac agc tgc cga     1632
 Arg Arg Ala Glu Thr Ser Leu His Thr Asp Gly Glu Asn Ser Cys Arg
     370                 375                 380

 tac tac cca atg ggc cac cca gca tct gtg cac ctc tac ttc ctt gct     1680
 Tyr Tyr Pro Met Gly His Pro Ala Ser Val His Leu Tyr Phe Leu Ala
 385                 390                 395                 400

 gac cgc ttc cag ggc ttt ctg atc aag cat cat gct acc aat ctg gct     1728
 Asp Arg Phe Gln Gly Phe Leu Ile Lys His His Ala Thr Asn Leu Ala
                 405                 410                 415

 gtg agc aaa cta gag act ctg gag acc tgg gtg atg ccg aaa aaa gtc     1776
 Val Ser Lys Leu Glu Thr Leu Glu Thr Trp Val Met Pro Lys Lys Val
             420                 425                 430

 ttc aag atc gca agc cca ccc agt gac ttt ggg agg ctt cag ttt tcc     1824
 Phe Lys Ile Ala Ser Pro Pro Ser Asp Phe Gly Arg Leu Gln Phe Ser
         435                 440                 445

 gag gtc ggc act gac tgg gat gcc aag gag agg cta ttc cgc aac ttt     1872
 Glu Val Gly Thr Asp Trp Asp Ala Lys Glu Arg Leu Phe Arg Asn Phe
     450                 455                 460

 ggg ggt ctt ctg ggg ccc atg gat gag ccg gtg ggt atg cag aag tgg     1920
 Gly Gly Leu Leu Gly Pro Met Asp Glu Pro Val Gly Met Gln Lys Trp
 465                 470                 475                 480

 ggg aag gga cct aat gtg acc gtg acc gtc att tgg gtg gat ccc gtc     1968
 Gly Lys Gly Pro Asn Val Thr Val Thr Val Ile Trp Val Asp Pro Val
                 485                 490                 495

 aat gtc atc gca gcc acc tac gac atc ctc att gag tcc act gcc gaa     2016
 Asn Val Ile Ala Ala Thr Tyr Asp Ile Leu Ile Glu Ser Thr Ala Glu
             500                 505                 510

 ttc aca cac tac aag ccc cct ttg aac ttg ccc ctg agg cct ggg gtc     2064
 Phe Thr His Tyr Lys Pro Pro Leu Asn Leu Pro Leu Arg Pro Gly Val
         515                 520                 525

 tgg aca gtg aaa att ctc cac cac tgg gtg cca gtt gca gag acc aaa     2112
 Trp Thr Val Lys Ile Leu His His Trp Val Pro Val Ala Glu Thr Lys
     530                 535                 540

 ttc ctc gtt gcg cct ctg acc ttc tcg aac agg cag ccc atc aaa cct     2160
 Phe Leu Val Ala Pro Leu Thr Phe Ser Asn Arg Gln Pro Ile Lys Pro
 545                 550                 555                 560

 gag gag gca ctg aag ctg cac aat ggg ccc ctc cgc aat gcc tac atg     2208
 Glu Glu Ala Leu Lys Leu His Asn Gly Pro Leu Arg Asn Ala Tyr Met
                 565                 570                 575

 gag cag agc ttc cag agc cta aac ccc gtc ctc agc ctg ccc atc aac     2256
 Glu Gln Ser Phe Gln Ser Leu Asn Pro Val Leu Ser Leu Pro Ile Asn
             580                 585                 590

 ccc gcc cag gtg gaa cag gca cgg agg aac gca gcc tcc acg ggc aca     2304
 Pro Ala Gln Val Glu Gln Ala Arg Arg Asn Ala Ala Ser Thr Gly Thr
         595                 600                 605

 gcg ctg gag gga tgg ctg gac tcg ttg gtg ggc ggg atg tgg act gcc     2352
 Ala Leu Glu Gly Trp Leu Asp Ser Leu Val Gly Gly Met Trp Thr Ala
     610                 615                 620

 atg gac atc tgt gcc acg ggc ccc aca gcc tgc ccg gtc atg cag acc     2400
 Met Asp Ile Cys Ala Thr Gly Pro Thr Ala Cys Pro Val Met Gln Thr
 625                 630                 635                 640

 tgc agc cag acg gcc tgg agc tcc ttc agc cct gac ccc aag tcg gag     2448
 Cys Ser Gln Thr Ala Trp Ser Ser Phe Ser Pro Asp Pro Lys Ser Glu
                 645                 650                 655

 ctg ggt gcc gtc aaa cct gat ggc cgg ctc agg tag                     2484
 Leu Gly Ala Val Lys Pro Asp Gly Arg Leu Arg 
             660                 665





      <210> 479
      <211> 416
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (133)..(372)

      <400> 479
 ctcagaacaa cgacacactg ttgaggtcgg gactggacac ttccttgttg tggggcgccc     60

 tgtgtgtcat atgatgttta gcagcatctg tgcctccctc agtggacgcc tgtagcacca    120

 gggctcccgg gc    atg aca gcc gga aat gtc ccc tgg cag gca acg gtg     168
                  Met Thr Ala Gly Asn Val Pro Trp Gln Ala Thr Val
                    1               5                  10

 acc cca gtt gag aag cac tgc gtt atg tct gtc caa tta cct tcc cag      216
 Thr Pro Val Glu Lys His Cys Val Met Ser Val Gln Leu Pro Ser Gln
          15                  20                  25

 aag cat cgg gcc tgc acc cgg tgg agc ttt ggc tac atc tcc ttg agc      264
 Lys His Arg Ala Cys Thr Arg Trp Ser Phe Gly Tyr Ile Ser Leu Ser
      30                  35                  40

 ccc tct gtg cct gtc tgc agc ctg gtc tcg gtg ccg att ggg aaa gaa      312
 Pro Ser Val Pro Val Cys Ser Leu Val Ser Val Pro Ile Gly Lys Glu
  45                  50                  55                  60

 tcc ttt gga gtg ccc tcc ctc ccc cgg tgc gtg tac ttg act gtg gga      360
 Ser Phe Gly Val Pro Ser Leu Pro Arg Cys Val Tyr Leu Thr Val Gly
                  65                  70                  75

 acc cca aga tga acc tcggcttttc tcagttcacc ccggaagcct tggcaagtct      415
 Thr Pro Arg 


 c                                                                    416




      <210> 480
      <211> 1241
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (171)..(539)

      <400> 480
 gcagagcccg gtacccgttc gctactgtgc gcatagcatt ccaccaggac tcatctccct     60

 tccttctcag ggggtcccga gccccgacta gctttgccct aactccttca tcaaaagacc    120

 ccccgccagc ttcccacacc tcatacgcag ccacatctgc cctattctcc   atg ctt     176
                                                          Met Leu
                                                            1

 tcc agc ttg cct gcc ctt cct cat ctc tcc ctg cct gtg cag acc tcc      224
 Ser Ser Leu Pro Ala Leu Pro His Leu Ser Leu Pro Val Gln Thr Ser
           5                  10                  15

 acc ctt ctt tcc tcc acc cct cca tcc ccc aat gct tgt aga cct tcc      272
 Thr Leu Leu Ser Ser Thr Pro Pro Ser Pro Asn Ala Cys Arg Pro Ser
      20                  25                  30

 att cat tcc gtc tca tcg tgc gtg gtc tct gat cgt cca tca cct gac      320
 Ile His Ser Val Ser Ser Cys Val Val Ser Asp Arg Pro Ser Pro Asp
  35                  40                  45                  50

 ctt ctc cag gac tgt ctt ctc acc ctt ccc cac tcc ctg gtc ccc ggg      368
 Leu Leu Gln Asp Cys Leu Leu Thr Leu Pro His Ser Leu Val Pro Gly
                  55                  60                  65

 agc agc tcc ttc tgc ccg act cac tca cag tgc agg gaa agg agg cag      416
 Ser Ser Ser Phe Cys Pro Thr His Ser Gln Cys Arg Glu Arg Arg Gln
              70                  75                  80

 gga aaa gac cag gat tct gtg agt tct gag gtt gcc aca cac aaa gaa      464
 Gly Lys Asp Gln Asp Ser Val Ser Ser Glu Val Ala Thr His Lys Glu
          85                  90                  95

 gct gtg gtt tct ctg cct cgg cca ctg atg aga cta aaa ctg gct tcc      512
 Ala Val Val Ser Leu Pro Arg Pro Leu Met Arg Leu Lys Leu Ala Ser
     100                 105                 110

 cct tgg aga cgg cag att tca ggc tga tccct gcttaagccc tctcatcccc      564
 Pro Trp Arg Arg Gln Ile Ser Gly 
 115                 120

 acgctggtcc tggtattgat acaagaccca gctggtgaca aagcctccaa tcctgggggt    624

 ccacgagcct gggcctgaca ttcccagaac taccgccagg tggcgccagg cccccacagt    684

 ctgtggccgt ggtcttagcc cccagttcca ctctggatgg gcctgtgaca ccccaaagag    744

 aagaagggga ctctggatag ggtccccaca tccagggcgt ggggagacca ttggcatttg    804

 ggaaccattt tccttcgaac ggcttcccct tgagctgagc attctgcttg ctgcagtaga    864

 cgggtcgcct tttgcccata ccgaaatttt ctgaaattaa atcgcacacc cccaccattt    924

 cctctccctg ggatctggag gaacatcata catagtaggt gaatcgtttt gtagagtgaa    984

 gaatgctaat gtaaagcaaa tagtcaccca cgttccttgt aaatccaaat gtttctatat   1044

 tgtagctttg cttaaaatgg ggtcggcccc aactgcatcc tcctctttgg cgggctgggg   1104

 agcggccccc agccgggacg ggagggcagc gaccccgagg cctcgtggac gtgggagaga   1164

 gtgtggtggg aagtcttgag cggaggaggg gatctgccct tctccactcc tctcttggat   1224

 ccgcctcggt ttcctgt                                                  1241




      <210> 481
      <211> 1129
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (10)..(237)

      <400> 481
 gcggaggtg    atg ccg cgc ggt cgc agg ctt ggg atg gtg ttc gcg cct      48
              Met Pro Arg Gly Arg Arg Leu Gly Met Val Phe Ala Pro
                1               5                  10

 ccg aga ccc gga cag agg caa gca ggg gcg ccg tgg gtg cca gag agg       96
 Pro Arg Pro Gly Gln Arg Gln Ala Gly Ala Pro Trp Val Pro Glu Arg
      15                  20                  25

 cgg aag agg agg cct gat ggg gat acc ttc ctg ctg tcc ttc ctg agc      144
 Arg Lys Arg Arg Pro Asp Gly Asp Thr Phe Leu Leu Ser Phe Leu Ser
  30                  35                  40                  45

 aca acc tgg ctg aaa acc tgg agg tca caa cag tac aaa gaa tca aag      192
 Thr Thr Trp Leu Lys Thr Trp Arg Ser Gln Gln Tyr Lys Glu Ser Lys
                  50                  55                  60

 tca aga tct tgt gcc aga gag caa atg aac tct tcc tct tgc tga gaa      240
 Ser Arg Ser Cys Ala Arg Glu Gln Met Asn Ser Ser Ser Cys 
              65                  70                  75

 aacccaccct gctcacctaa accctggcct tgcctggtaa ttccatccat gcgcctggaa    300

 ggccccagac atcaaggctc tgaggggcca ggcacgggga gaacccagca gtgccctgcc    360

 ctgcagtctg agctaccaga ttccttgtga agataatttg aggaccatga ctcacccaac    420

 cacatttcct ggggcctcaa attgaaaatt caggatgggc ttttctatat gactggctga    480

 tatccaacta tgccatggtc tttacatgcc atgaacattc tttcctgcca gagttctaag    540

 aatctgtgtt ctctgcctta gaccttctgc agatgagccc acaggaagct ccacgtgtag    600

 ctgagctaca tgcaccaggc ctcagtttgc cccaagtccc ctgtgtactc tctcatggcc    660

 tgtggccaag aaatgtattc tctcactttg gacttaggag tccaaagaga agcccagaaa    720

 caaaattgct tgaacttgaa ctccgtgtgc gtgcgcacgt gtgcccgtgg tgggtgaagg    780

 tgtatgtcac ggcttgtcta tgcgtcatgg tcacaaactc ccaaatatag tacattgtct    840

 agatgatgtt ggtggacaaa ctccaacaga gttaactcgc aaactctggg cccgggccca    900

 caataggccc gagaaccggc agctgcgggt caaaccaagg agaacgagat accacaagca    960

 tgggaacgcg cgagcacaaa ccccctagcg atagcagtaa ccaaactgcg cgggcccaac   1020

 gcaccccaga agagcggaaa cagcagccga aagcgcagcg gcccaaggga caaccagcag   1080

 acaaacgacg cacacaaaca tgatggacag agagcaacca cgcaacaca               1129




      <210> 482
      <211> 512
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (38)..(418)

      <400> 482
 gctcctcccg ctagggcgat agcacgcggg gcccaag atg gcg gcc agc gtg tac      55
                                          Met Ala Ala Ser Val Tyr
                                            1               5

 cgg gtg ttt ctt aag ctc tgt gag gaa tgg cca gtg gac gag acc aaa      103
 Arg Val Phe Leu Lys Leu Cys Glu Glu Trp Pro Val Asp Glu Thr Lys
              10                  15                  20

 cgg ggc cgg gac ttg ggc gct tac ctg cga cag cgg gta gca cag gcc      151
 Arg Gly Arg Asp Leu Gly Ala Tyr Leu Arg Gln Arg Val Ala Gln Ala
          25                  30                  35

 ttt cgg gaa gga gag aat acc cag gtt gca gag cct gag gcc tgt gat      199
 Phe Arg Glu Gly Glu Asn Thr Gln Val Ala Glu Pro Glu Ala Cys Asp
      40                  45                  50

 cag atg tac gag agc tta gcg cga ctc cat tca aac tac tac aaa cac      247
 Gln Met Tyr Glu Ser Leu Ala Arg Leu His Ser Asn Tyr Tyr Lys His
  55                  60                  65                  70

 aag tac cct cgc ccc aga gac acc agc ttc agt ggc ctg tcg ttg gaa      295
 Lys Tyr Pro Arg Pro Arg Asp Thr Ser Phe Ser Gly Leu Ser Leu Glu
                  75                  80                  85

 gag tac aag ctg atc ctg tcc aca gac acc ttg gaa gag ctt aag gaa      343
 Glu Tyr Lys Leu Ile Leu Ser Thr Asp Thr Leu Glu Glu Leu Lys Glu
              90                  95                 100

 ata gat aaa ggc atg tgg aag aaa ctg cag gag aag ttt gcc ccc aag      391
 Ile Asp Lys Gly Met Trp Lys Lys Leu Gln Glu Lys Phe Ala Pro Lys
         105                 110                 115

 ggt cct gag gag gat cat aag gcc tga gctca ggccttacct cgtgcacata      443
 Gly Pro Glu Glu Asp His Lys Ala 
     120                 125

 cctaggtgtg gagtcttgta cattgccatc gtcaataaaa ctgccccagt ttccccttga    503

 aaaaaaaaa                                                            512




      <210> 483
      <211> 1543
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (78)..(674)

      <400> 483
 ggaaccatca ttaattgaag tgagattttt ctggcctgag acttgcaggg aggcaagaag     60

 acactctgga caccact   atg gac agc ctc ttg atg aac cgg agg aag ttt     110
                      Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe
                        1               5                  10

 ctt tac caa ttc aaa aat gtc cgc tgg gct aag ggt cgg cgt gag acc      158
 Leu Tyr Gln Phe Lys Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr
              15                  20                  25

 tac ctg tgc tac gta gtg aag agg cgt gac agt gct aca tcc ttt tca      206
 Tyr Leu Cys Tyr Val Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser
          30                  35                  40

 ctg gac ttt ggt tat ctt cgc aat aag aac ggc tgc cac gtg gaa ttg      254
 Leu Asp Phe Gly Tyr Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu
      45                  50                  55

 ctc ttc ctc cgc tac atc tcg gac tgg gac cta gac cct ggc cgc tgc      302
 Leu Phe Leu Arg Tyr Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys
  60                  65                  70                  75

 tac cgc gtc acc tgg ttc acc tcc tgg agc ccc tgc tac gac tgt gcc      350
 Tyr Arg Val Thr Trp Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala
                  80                  85                  90

 cga cat gtg gcc gac ttt ctg cga ggg aac ccc aac ctc agt ctg agg      398
 Arg His Val Ala Asp Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg
              95                 100                 105

 atc ttc acc gcg cgc ctc tac ttc tgt gag gac cgc aag gct gag ccc      446
 Ile Phe Thr Ala Arg Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro
         110                 115                 120

 gag ggg ctg cgg cgg ctg cac cgc gcc ggg gtg caa ata gcc atc atg      494
 Glu Gly Leu Arg Arg Leu His Arg Ala Gly Val Gln Ile Ala Ile Met
     125                 130                 135

 acc ttc aaa gat tat ttt tac tgc tgg aat act ttt gta gaa aac cat      542
 Thr Phe Lys Asp Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His
 140                 145                 150                 155

 gaa aga act ttc aaa gcc tgg gaa ggg ctg cat gaa aat tca gtt cgt      590
 Glu Arg Thr Phe Lys Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg
                 160                 165                 170

 ctc tcc aga cag ctt cgg cgc atc ctt ttg ccc ctg tat gag gtt gat      638
 Leu Ser Arg Gln Leu Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp
             175                 180                 185

 gac tta cga gac gca ttt cgt act ttg gga ctt tga tagc aacttccagg      688
 Asp Leu Arg Asp Ala Phe Arg Thr Leu Gly Leu 
         190                 195

 aatgtcacac acgatgaaat atctctgctg aagacagtgg ataaaaaaca gtccttcaag    748

 tcttctctgt ttttattctt caactctcac tttcttagag tttacagaaa aaatatttat    808

 atacgactct ttaaaaagat ctatgtcttg aaaatagaga aggaacacag gtctggccag    868

 ggacgtgctg caattggtgc agttttgaat gcaacattgt cccctactgg gaataacaga    928

 actgcaggac ctgggagcat cctaaagtgt caacgttttt ctatgacttt taggtaggat    988

 gagagcagaa ggtagatcct aaaaagcatg gtgagaggat caaatgtttt tatatcaaca   1048

 tcctttatta tttgattcat ttgagttaac agtggtgtta gtgatagatt tttctattct   1108

 tttcccttga cgtttacttt caagtaacac aaactcttcc atcaggccat gatctatagg   1168

 acctcctaat gagagtatct gggtgattgt gaccccaaac catctctcca aagcattaat   1228

 atccaatcat gcgctgtatg ttttaatcag cagaagcatg tttttatgtt tgtacaaaag   1288

 aagattgtta tgggtgggga tggaggtata gaccatgcat ggtcaccttc aagctacttt   1348

 aataaaggat cttaaaatgg gcaggaggac tgtgaacaag acaccctaat aatgggttga   1408

 tgtctgaagt agcaaatctt ctggaaacgc aaactctttt aaggaagtcc ctaatttaga   1468

 aacacccaca aacttcacat atcataatta gcaaacaatt ggaaggaagt tgcttgaatg   1528

 ttggggagag gaaaa                                                    1543




      <210> 484
      <211> 820
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (56)..(820)

      <400> 484
 cctctcatct ttctgttttt aggagatcaa tgatctgttg gttaaggaaa agatt atg      58
                                                              Met
                                                                1

 caa ctt gtc cag cag aga tca caa atc caa acc ctt cag aag aag gta      106
 Gln Leu Val Gln Gln Arg Ser Gln Ile Gln Thr Leu Gln Lys Lys Val
               5                  10                  15

 gta aac ttg gag act gct ctg agt tac atg acc aaa gag ttt gag agt      154
 Val Asn Leu Glu Thr Ala Leu Ser Tyr Met Thr Lys Glu Phe Glu Ser
          20                  25                  30

 gaa gtt tta aaa ctg cag caa cac gca atg ata gag aac caa gca ggt      202
 Glu Val Leu Lys Leu Gln Gln His Ala Met Ile Glu Asn Gln Ala Gly
      35                  40                  45

 cag gta gaa att gac aag ctg cag cac ctt ctt cag atg aag gac agg      250
 Gln Val Glu Ile Asp Lys Leu Gln His Leu Leu Gln Met Lys Asp Arg
  50                  55                  60                  65

 gaa atg aat cgt gtg aag aag ctg gcc aag aac ata ctg gat gag aga      298
 Glu Met Asn Arg Val Lys Lys Leu Ala Lys Asn Ile Leu Asp Glu Arg
                  70                  75                  80

 aca gaa gtg gaa aga ttc ttt tta gat gct ctg cac caa gtg aag caa      346
 Thr Glu Val Glu Arg Phe Phe Leu Asp Ala Leu His Gln Val Lys Gln
              85                  90                  95

 cag atc cta att agc agg aag cat tat aag cag ata gca caa gct gct      394
 Gln Ile Leu Ile Ser Arg Lys His Tyr Lys Gln Ile Ala Gln Ala Ala
         100                 105                 110

 ttc aat tta aaa atg aga gca gca tgt aca gga aga aca gaa tat ccc      442
 Phe Asn Leu Lys Met Arg Ala Ala Cys Thr Gly Arg Thr Glu Tyr Pro
     115                 120                 125

 aaa atc aga aca ttt gat ggc aga gag cac agc acc aat agt gtg aat      490
 Lys Ile Arg Thr Phe Asp Gly Arg Glu His Ser Thr Asn Ser Val Asn
 130                 135                 140                 145

 cag gat ctt ctg gag gcc gaa aaa tgg aca cat att gaa gga aat gtg      538
 Gln Asp Leu Leu Glu Ala Glu Lys Trp Thr His Ile Glu Gly Asn Val
                 150                 155                 160

 gat att gga gat ttg acc tgg gag cag aag gaa aaa gta ttg cga ttg      586
 Asp Ile Gly Asp Leu Thr Trp Glu Gln Lys Glu Lys Val Leu Arg Leu
             165                 170                 175

 ctc ttt gca aaa atg aat ggc tgt cct tct agg aaa tac aac cag agt      634
 Leu Phe Ala Lys Met Asn Gly Cys Pro Ser Arg Lys Tyr Asn Gln Ser
         180                 185                 190

 tct agg cct cca gtt cca gac tat gtt gtt tct gac agt ggg gaa aca      682
 Ser Arg Pro Pro Val Pro Asp Tyr Val Val Ser Asp Ser Gly Glu Thr
     195                 200                 205

 aag gaa ttt ggg gat gaa agt aag ctt caa gat aaa atc ttc atc acc      730
 Lys Glu Phe Gly Asp Glu Ser Lys Leu Gln Asp Lys Ile Phe Ile Thr
 210                 215                 220                 225

 cag caa att gca ata tca gac tct tct ggt gaa gtg gtg cta ccc act      778
 Gln Gln Ile Ala Ile Ser Asp Ser Ser Gly Glu Val Val Leu Pro Thr
                 230                 235                 240

 att cca aaa gaa cct cag gag tct gac aca gga acc ttc tga              820
 Ile Pro Lys Glu Pro Gln Glu Ser Asp Thr Gly Thr Phe 
             245                 250





      <210> 485
      <211> 1526
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (683)..(1081)

      <400> 485
 cagaaaaggt agaagatcct cagtgaatga cgttgcaggg tcttcatgca attttccacc     60

 tcgcagtagt tagtatttac ttgccttaaa ctaactttga agcaagtaat gtcaactttg    120

 agcactttgt tgagttttga aaaatcttat ttgttgctgc acaggttaat aaattatcaa    180

 tttgtaattc agcatgttgg tcagagacac ggtcactgat tcacacccag tccctgccac    240

 agaccgtctc agacacgcac agtgggcctg ctgcatgatt cacacccagt ccctgccaca    300

 gaccgtctca gacacgcaca gtgggcctgc tgcatgcgtg ttacctggct tttggctcca    360

 cgctcactca tagccatgtc cacatggggg gcttgcacac aggatcactc acatatgtac    420

 atgtacccac cacaaacgtg caagctcctg cacacatgca tgcacacaaa cgtgtacaca    480

 agtgtgagct cctacacgca tacacacaca cacgtgtaca tgcaccaaag catgtgtgac    540

 ctacagacat gcagaacatg cacgtgtaca cataccacag acacgcgtgt gcatgctcct    600

 acacaataca tatgcacata tcatgaacag cgtaagttcc tacacacgga cgtgtgatac    660

 atgcatgtac aggtaagcac ac atg tac aag ctc cta cag gct tgc tct cac     712
                          Met Tyr Lys Leu Leu Gln Ala Cys Ser His
                            1               5                  10

 aca cgt gta tgc aca gca gag aga cgt atg agc ttc tac tgc aca cat      760
 Thr Arg Val Cys Thr Ala Glu Arg Arg Met Ser Phe Tyr Cys Thr His
                  15                  20                  25

 gca cac aca cac gca cac gta cat tca cta cac acg tgc agc ctc ctg      808
 Ala His Thr His Ala His Val His Ser Leu His Thr Cys Ser Leu Leu
              30                  35                  40

 cac acg tgc aca ttc atg tgt aca cca caa atg agt tcc cat acg tgt      856
 His Thr Cys Thr Phe Met Cys Thr Pro Gln Met Ser Ser His Thr Cys
          45                  50                  55

 aaa cac acg tgc aca cat cgt aca cat gtg agc tcc cac acg tac aca      904
 Lys His Thr Cys Thr His Arg Thr His Val Ser Ser His Thr Tyr Thr
      60                  65                  70

 cag atg cac atg gac aca ccc caa aca cgc aca ggc tcc tac aca cat      952
 Gln Met His Met Asp Thr Pro Gln Thr Arg Thr Gly Ser Tyr Thr His
  75                  80                  85                  90

 gca cac acg tgt aca cca caa acg agc tcc cag aca tgt aaa cac acg     1000
 Ala His Thr Cys Thr Pro Gln Thr Ser Ser Gln Thr Cys Lys His Thr
                  95                 100                 105

 tct ccc aca cgt gag ctc cca cac atg tac aca tgc aca tgt acg cac     1048
 Ser Pro Thr Arg Glu Leu Pro His Met Tyr Thr Cys Thr Cys Thr His
             110                 115                 120

 cac aaa cac atg cgc agg ctc ctg cag gcg tga atacacac atgcacacac     1099
 His Lys His Met Arg Arg Leu Leu Gln Ala 
         125                 130

 atatacacac atgtgccaca aacaagtgca cactgtcctg gtgtcctgca ctgcatcctg   1159

 cctccttgct gaggggcccc tgtgagaggc ctctggatgg gcatgggaag atgggctccc   1219

 tggcccccag cccatgcctc cctgggatga agagtccccc tcctggcaga atgtctgggc   1279

 tttgcagagc aggccccggg ggtgaagtcg cagcttcact tacaccagct gctctgtgag   1339

 caaggcttgg tgccctggac aaggcccttc ccctttaggg aggtccagcc tcgcaagctg   1399

 aaacctcccc tcggctcagc cctataccag gcggccacag caggactggc cacacccacg   1459

 ccgcacctca tccgtgcacg cgtcggagca cggccagcct tctgccacga gccagctggg   1519

 aagggcc                                                             1526




      <210> 486
      <211> 826
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (101)..(382)

      <400> 486
 gagggcgaag cgatgtcaga aataatagaa aaggcttttt cctttgaaat atctaaacgt     60

 tcaaagatgg gaacagccgc aggggggaga atactgtgct  atg caa gtt gat ctg     115
                                              Met Gln Val Asp Leu
                                                1               5

 att ttg tgg acc atc cat ttc caa ttg gga agc tca ctt act ttc aac      163
 Ile Leu Trp Thr Ile His Phe Gln Leu Gly Ser Ser Leu Thr Phe Asn
                  10                  15                  20

 ttg aag cat cag aaa acc aga ctt aca gca gct tca gcc tat agg ggt      211
 Leu Lys His Gln Lys Thr Arg Leu Thr Ala Ala Ser Ala Tyr Arg Gly
              25                  30                  35

 tta ttt ttc tca tgt aac aag aag aac aga agt gga cag agg ccg agt      259
 Leu Phe Phe Ser Cys Asn Lys Lys Asn Arg Ser Gly Gln Arg Pro Ser
          40                  45                  50

 tct caa gga ctc agt ttc ttt ctg tcc cac caa cct tac cat gtt gga      307
 Ser Gln Gly Leu Ser Phe Phe Leu Ser His Gln Pro Tyr His Val Gly
      55                  60                  65

 ttg tca tct ttg tgc ttg ttg cct cat gat ggc aag atg gct gca gca      355
 Leu Ser Ser Leu Cys Leu Leu Pro His Asp Gly Lys Met Ala Ala Ala
  70                  75                  80                  85

 cct ctg gga ctc acg act gat ttt taa gacta cagagcctaa gtcaaagctt      407
 Pro Leu Gly Leu Thr Thr Asp Phe 
                  90

 gttcttggac ccaggaaata tgtcaaatcc ttccagtgaa tggtgccttt caggattgga    467

 gactactccc ccagttgctg atggtgtggt cagccctcag ttttcagtcc tctttgggaa    527

 ttgccttgga tgaagaaagt cacctcaccc aagatcactc caactcctgg gacccacatc    587

 caatgattgg ccaatatggg gactcaaagg cctggtcccc cttccccaac ttgagactac    647

 tctgaaggat cacccagctt cagagcttcc catggttgag acttttagac ttcactgtgg    707

 tccaaccaat ctcttcctat acacggtcct gactccttca cttccctccc agcacttctt    767

 ctgtgttaat atcaaacttc tgtgctaata acaaacttct tccgtgctaa aaaaaaaaa     826




      <210> 487
      <211> 2342
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2199)

      <400> 487
  atg gca gac ctg aaa aac ctg ccg ggc ccg cct ctg ggt gtg ggg ggt      48
  Met Ala Asp Leu Lys Asn Leu Pro Gly Pro Pro Leu Gly Val Gly Gly
    1               5                  10                  15

 gcc ctc tac tgc tct ccc gct gca gct ggt ccc tgg gac agg atg ggg       96
 Ala Leu Tyr Cys Ser Pro Ala Ala Ala Gly Pro Trp Asp Arg Met Gly
              20                  25                  30

 gcc atg ggg tca ctg gca aga ctc gtg gct gtg acc cat ggg cct ctg      144
 Ala Met Gly Ser Leu Ala Arg Leu Val Ala Val Thr His Gly Pro Leu
          35                  40                  45

 agg agg cgt tgt aag tcc gcc cag ctc ccc act tgc tgt gct ctc act      192
 Arg Arg Arg Cys Lys Ser Ala Gln Leu Pro Thr Cys Cys Ala Leu Thr
      50                  55                  60

 caa tgc gaa ggg aac caa ggt acc agg gcc aag tgg gtc cag aca tcc      240
 Gln Cys Glu Gly Asn Gln Gly Thr Arg Ala Lys Trp Val Gln Thr Ser
  65                  70                  75                  80

 aca cgg att ctg aaa ggg cag gtc aag cag act ttg tcc agc cat cag      288
 Thr Arg Ile Leu Lys Gly Gln Val Lys Gln Thr Leu Ser Ser His Gln
                  85                  90                  95

 cca cgg cct ctc gac agc acc aag atg gaa gtc aaa ggt cag ctg atc      336
 Pro Arg Pro Leu Asp Ser Thr Lys Met Glu Val Lys Gly Gln Leu Ile
             100                 105                 110

 agc tct cct acc ttc aat gcc cca gct gcc ctg ttc gga gag gct gcc      384
 Ser Ser Pro Thr Phe Asn Ala Pro Ala Ala Leu Phe Gly Glu Ala Ala
         115                 120                 125

 ccc cag gtg aag tca gag cgt ctg cgg ggg ctg ctt gac cgg cag cgg      432
 Pro Gln Val Lys Ser Glu Arg Leu Arg Gly Leu Leu Asp Arg Gln Arg
     130                 135                 140

 acc ctg cag gag gcc ctg agc ctg aaa ctt cag gag ctc cgc aaa gtg      480
 Thr Leu Gln Glu Ala Leu Ser Leu Lys Leu Gln Glu Leu Arg Lys Val
 145                 150                 155                 160

 tgt ctc cag gag gcg gag ctg act ggc cag ctg ccc cct gag tgc cca      528
 Cys Leu Gln Glu Ala Glu Leu Thr Gly Gln Leu Pro Pro Glu Cys Pro
                 165                 170                 175

 cta gag cct ggt gaa cgg ccc cag ttg gtc cgc cgg cgg ccc ccc aca      576
 Leu Glu Pro Gly Glu Arg Pro Gln Leu Val Arg Arg Arg Pro Pro Thr
             180                 185                 190

 gcc cgc gcc tac cct cca ccg cac ccc aac caa gca cac cac tcc ttg      624
 Ala Arg Ala Tyr Pro Pro Pro His Pro Asn Gln Ala His His Ser Leu
         195                 200                 205

 tgc cct gct gag gag ctg gct ctt gag gcc ctg gaa cgc gag gtg tca      672
 Cys Pro Ala Glu Glu Leu Ala Leu Glu Ala Leu Glu Arg Glu Val Ser
     210                 215                 220

 gtg caa cag cag atc gcg gcg gcc gcc cgc cgc ctg gcc ttg gcc cct      720
 Val Gln Gln Gln Ile Ala Ala Ala Ala Arg Arg Leu Ala Leu Ala Pro
 225                 230                 235                 240

 gat ctg agc acc gag cag cgc cgg cgc cgg cgc cag gtc cag gca gat      768
 Asp Leu Ser Thr Glu Gln Arg Arg Arg Arg Arg Gln Val Gln Ala Asp
                 245                 250                 255

 gca ctg agg agg ctg cat gag cta gag gag cag ctc agg gat gtc cgg      816
 Ala Leu Arg Arg Leu His Glu Leu Glu Glu Gln Leu Arg Asp Val Arg
             260                 265                 270

 gcc cgc ctt ggc ctc cca gtg ctc ccg ctg ccc cag cca ctg cca ctg      864
 Ala Arg Leu Gly Leu Pro Val Leu Pro Leu Pro Gln Pro Leu Pro Leu
         275                 280                 285

 tcc acg ggg tca gtg atc acc acc cag gga gtc tgc ctg ggc atg cgt      912
 Ser Thr Gly Ser Val Ile Thr Thr Gln Gly Val Cys Leu Gly Met Arg
     290                 295                 300

 ctt gct cag ctc agc caa gag gac gta gtt ctg cac tca gag agc agc      960
 Leu Ala Gln Leu Ser Gln Glu Asp Val Val Leu His Ser Glu Ser Ser
 305                 310                 315                 320

 tcc ctc tca gag tct ggg gcc agc cat gac aac gag gag ccc cat ggc     1008
 Ser Leu Ser Glu Ser Gly Ala Ser His Asp Asn Glu Glu Pro His Gly
                 325                 330                 335

 tgc ttc tct ctg gcc gag cgc ccc tca cca ccc aag gct tgg gac cag     1056
 Cys Phe Ser Leu Ala Glu Arg Pro Ser Pro Pro Lys Ala Trp Asp Gln
             340                 345                 350

 ctg cgg gca gta tct ggg ggg agc cct gag cgg cga acc cca tgg aaa     1104
 Leu Arg Ala Val Ser Gly Gly Ser Pro Glu Arg Arg Thr Pro Trp Lys
         355                 360                 365

 cca cct cca tca gat ctt tat ggg gat ctg aag agc cgg cgg aac tct     1152
 Pro Pro Pro Ser Asp Leu Tyr Gly Asp Leu Lys Ser Arg Arg Asn Ser
     370                 375                 380

 gtg gcc agc ccc acc aga cct gaa ggc ctt cat tct cgt cag tgg tcc     1200
 Val Ala Ser Pro Thr Arg Pro Glu Gly Leu His Ser Arg Gln Trp Ser
 385                 390                 395                 400

 ggc agc cag gac tcc cag atg ggc ttc ccc cgg gcg gac cct gcc tcc     1248
 Gly Ser Gln Asp Ser Gln Met Gly Phe Pro Arg Ala Asp Pro Ala Ser
                 405                 410                 415

 gat cgc gcc tcc ctc ttc gta gct cgc acc cgc cgc agc aac agt tct     1296
 Asp Arg Ala Ser Leu Phe Val Ala Arg Thr Arg Arg Ser Asn Ser Ser
             420                 425                 430

 gag gcc ctg ctg gtg gac cgg gcc gct ggt ggg gga gct ggc tcc ccg     1344
 Glu Ala Leu Leu Val Asp Arg Ala Ala Gly Gly Gly Ala Gly Ser Pro
         435                 440                 445

 cct gcc cct ctg gct ccc tct gcc tct ggc ccc cca gtc tgc aag agc     1392
 Pro Ala Pro Leu Ala Pro Ser Ala Ser Gly Pro Pro Val Cys Lys Ser
     450                 455                 460

 agt gag gtg ctg tat gag cgc ccc caa cca acc cct gcc ttc tcc tcc     1440
 Ser Glu Val Leu Tyr Glu Arg Pro Gln Pro Thr Pro Ala Phe Ser Ser
 465                 470                 475                 480

 cgc aca gca ggc ccc cca gac cct ccc cgg gcc gcc cgg cct agc tca     1488
 Arg Thr Ala Gly Pro Pro Asp Pro Pro Arg Ala Ala Arg Pro Ser Ser
                 485                 490                 495

 gct gcc cct gcc tcc cga ggt gcc ccc cgg ctc cca cct gtg tgt gga     1536
 Ala Ala Pro Ala Ser Arg Gly Ala Pro Arg Leu Pro Pro Val Cys Gly
             500                 505                 510

 gac ttc ctc ttg gac tat tcc ttg gac cgg ggc ctg ccc cgc agt ggc     1584
 Asp Phe Leu Leu Asp Tyr Ser Leu Asp Arg Gly Leu Pro Arg Ser Gly
         515                 520                 525

 ggt gga aca ggc tgg ggg gag ctg ccg cct gca gct gag gtc cca gga     1632
 Gly Gly Thr Gly Trp Gly Glu Leu Pro Pro Ala Ala Glu Val Pro Gly
     530                 535                 540

 ccc ctc tcc cgc cgg gat ggg ctc ctc acc atg ctc ccc ggc cca cca     1680
 Pro Leu Ser Arg Arg Asp Gly Leu Leu Thr Met Leu Pro Gly Pro Pro
 545                 550                 555                 560

 cct gtg tat gca gct gac agc aac agc ccc ctc ctc cgc acc aag gac     1728
 Pro Val Tyr Ala Ala Asp Ser Asn Ser Pro Leu Leu Arg Thr Lys Asp
                 565                 570                 575

 ccc cac acc cgt gcc acc cgc act aag ccc tgt ggc ctg ccc cca gag     1776
 Pro His Thr Arg Ala Thr Arg Thr Lys Pro Cys Gly Leu Pro Pro Glu
             580                 585                 590

 gct gcc gaa ggc cct gag gtg cat cca aac cct ctg ctg tgg atg ccc     1824
 Ala Ala Glu Gly Pro Glu Val His Pro Asn Pro Leu Leu Trp Met Pro
         595                 600                 605

 cca ccc acc cgt atc ccc tcg gct ggt gaa cgc agt ggc cac aag aac     1872
 Pro Pro Thr Arg Ile Pro Ser Ala Gly Glu Arg Ser Gly His Lys Asn
     610                 615                 620

 ctg gct ctg gag ggg ctg cgg gac tgg tac atc cgg aac tcg gga ctg     1920
 Leu Ala Leu Glu Gly Leu Arg Asp Trp Tyr Ile Arg Asn Ser Gly Leu
 625                 630                 635                 640

 gct gcg ggg ccc cag cgc cgg cct gtg ctc cct tcc gtg ggc ccg cca     1968
 Ala Ala Gly Pro Gln Arg Arg Pro Val Leu Pro Ser Val Gly Pro Pro
                 645                 650                 655

 cac cca ccc ttc ctc cat gcc cgc tgc tat gag gtg ggc cag gcg ctg     2016
 His Pro Pro Phe Leu His Ala Arg Cys Tyr Glu Val Gly Gln Ala Leu
             660                 665                 670

 tac ggg gcc ccc agc cag gcg cca ctc cca cac tcg agg agt ttc acg     2064
 Tyr Gly Ala Pro Ser Gln Ala Pro Leu Pro His Ser Arg Ser Phe Thr
         675                 680                 685

 gcg ccc cct gtc tct ggc aga tac tac gcg gac ttc ctg tat ccc ccg     2112
 Ala Pro Pro Val Ser Gly Arg Tyr Tyr Ala Asp Phe Leu Tyr Pro Pro
     690                 695                 700

 gag ctg agc gct cgt tta agt gac ctg acg cta gag ggg gag cag tcc     2160
 Glu Leu Ser Ala Arg Leu Ser Asp Leu Thr Leu Glu Gly Glu Gln Ser
 705                 710                 715                 720

 tcc agt tct gac acc cag acc ccg ggg aca ctg gtc tga ccccagttgg      2209
 Ser Ser Ser Asp Thr Gln Thr Pro Gly Thr Leu Val 
                 725                 730

 tcgccggcgg ccccccacag cccgcgccta ccctccaccg caccccaacc aagcacacca   2269

 ctccttgtgc cctgctgagg agctggctct tgaggccctg gaacgcgagg tgtcagtgca   2329

 acagcagatc gcg                                                      2342




      <210> 488
      <211> 511
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(221)

      <400> 488
 cgctcgaagt cgctaggact tctctcaaac ttgtgtgctg aggagactcg   atg tgg      56
                                                          Met Trp
                                                            1

 acc tca gct cct agg ctg aaa tca gca gac tgg ctc atg aaa act tgt      104
 Thr Ser Ala Pro Arg Leu Lys Ser Ala Asp Trp Leu Met Lys Thr Cys
           5                  10                  15

 gta ctg aga caa agg aaa gga tct agc aga aag caa cgt ctc tta tcc      152
 Val Leu Arg Gln Arg Lys Gly Ser Ser Arg Lys Gln Arg Leu Leu Ser
      20                  25                  30

 tgg gct tgg cag caa gga aga gga caa gta gtg gaa atc ctt caa tct      200
 Trp Ala Trp Gln Gln Gly Arg Gly Gln Val Val Glu Ile Leu Gln Ser
  35                  40                  45                  50

 gaa aag caa act gaa agg tga ca aagaagctga agatgggtgg cggagagagg      253
 Glu Lys Gln Thr Glu Arg 
                  55

 tataacattc cagaccctca atctagaaat gctagtaaga accaagaaca gcaaaataga    313

 cagaagagca aggatcagaa ttcttcccag acgaagattg ctcataagaa aaaggaacga    373

 ggacatgggt acaatccagc agcagcagca tgggcaggcc atgcaaaatg ggggaaagac    433

 caagagcctt tctaacaact ccaactggaa tgctggggta atcaagccca acttgctttt    493

 ttaatctcaa gctagtcc                                                  511




      <210> 489
      <211> 3088
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1744)..(2013)

      <400> 489
 gttaaaacac agttttattt actcatttat aaatactgtt gtgtttacag gcatcatata     60

 gaagtgaata ttattattcc caaactttca aacacagaat actcaaaact atataacaac    120

 aaccagtaaa acaaaaccat tcatcttagg gttgaaaggc cactcaaaat tgcataaaaa    180

 tacattcagt tcacaaagca agtctggctg cttctcccta aacaacccca accccacccc    240

 atcccaggtg tatttacagt ggactgaagt taatccatac aactcagctg aaaaacagtt    300

 acatctggtg tgtgaacctt ggtggaacta gggtgaaggg tggagtaaag acacaaaatg    360

 ctaccactaa aatgggagag gcatggaaac ctcagggtgg ttcttttcac ccctgttgat    420

 caaggtcagg gcaaagacaa ggaggaagga aaaccataaa gccaaagtct gagtgtgaac    480

 cactcaactg agcacaggct gtagcttctc caagaaggat gcaagggtga aacattcttt    540

 ccttccttct gcagggaaat cattgccctg gtgtgccagc cagtggtagg cacaaccttt    600

 caaaagttca agggatgctg gctagaaaag gaggtattct ggattgctgc ctcctctcag    660

 aaccctctcc taccccacag cctgcctcct ggtgtctttt ttcctccaaa ctctctttac    720

 ctaacctctc ttcatcagaa ggcaagcggg aatctgttcc gggtttcagt agagtgggag    780

 aaaggacagg caaaggcaca gatatttagg cgagagtcaa gctacttctg gcccttgcat    840

 gtcccttatt caggaatagt gggccccgac gactggcact ccgactctca actctggttt    900

 tgggagaaca ttagaggctc ttaagaggct ccccaccatc agtgtgcctt tcctgaatcc    960

 ttgctctttg aatgggctga gctgttgcca ccagatgcac tgatacactg attgattagg   1020

 tttgtgctgg gaagacacac ttctgtttta agctataaac aaacagtctc aggataaaga   1080

 gtaaaccaga catggctact catggtctcc ttggccaggc tatggaggag tcatacgggc   1140

 ctaaaagtca aacctcatct ctgaggggac attagcatag ccgaggagct ttgaaactgg   1200

 aatagggggc ggtggtggtg gtggttggta tacccaactt ctacaggaat cttggctgat   1260

 tcatggaaaa ccacctctct aaagcaccct cggctccaag tgagaaaagc aaggaattaa   1320

 gaatgcagag ggagatgaaa gggagaggag tgaagtgtat gcttattctg gaaggacata   1380

 agagcatcct gatgtcacct taaggggcca cccaagtaaa tctttattgg aaacatcagg   1440

 gaaaaatttg gaggagaaat aacagaaaat atcactctgg cagattcatg gtccaaaata   1500

 agcagatgaa ttggggaaca gctcaaatag gtcctttggg ggattagaag ggagggggaa   1560

 aaacaaaaga tatgatttaa taaataaaat tggtttctga gttttcattt gtaatcaagt   1620

 atatgccaga cctcatttta aaagctctgg gctagcaaat gtgcatgtga acgcacataa   1680

 gctagatcca agagttatcc ccaaattgct aaaccttttt aggtaaggcc agaacattca   1740

 tta  atg gta ttg tct tta gac aca ccc acc tct tac tta cag ttc tcc    1788
      Met Val Leu Ser Leu Asp Thr Pro Thr Ser Tyr Leu Gln Phe Ser
        1               5                  10                  15

 cga agg agg gct tcc ggg aca ctg ggt tgt aag cca aac ctg ggt tct     1836
 Arg Arg Arg Ala Ser Gly Thr Leu Gly Cys Lys Pro Asn Leu Gly Ser
                  20                  25                  30

 atg ttt gcc ctc aac ccc aac tct caa agg aga agt gaa tgc atc ttt     1884
 Met Phe Ala Leu Asn Pro Asn Ser Gln Arg Arg Ser Glu Cys Ile Phe
              35                  40                  45

 cac cat gca gct gct ggc tgc tgg cca aga ttc tgt gtt ttt tct cag     1932
 His His Ala Ala Ala Gly Cys Trp Pro Arg Phe Cys Val Phe Ser Gln
          50                  55                  60

 ccc tca gaa atc acc tca ttc cta gta gct gtg acc aac agt tcc tgg     1980
 Pro Ser Glu Ile Thr Ser Phe Leu Val Ala Val Thr Asn Ser Ser Trp
      65                  70                  75

 act aca atg aag ttg atc tat ttt cca atc taa tcagaaca caaaagatca     2031
 Thr Thr Met Lys Leu Ile Tyr Phe Pro Ile 
  80                  85

 atagctgtcc ctgacagggt ctactgcttc ctgagcagtg tcaataccca ttaaggaagc   2091

 tgattaaaat ctctgctcag ctggagcctg agggatgaag tcaccagtga gacagaactc   2151

 atttctgtgt gacaaagctt tgtttctgtg aaactctctt ccttcccagt acttgcagct   2211

 tccaccctgc tctatgtcca aagcccctgg gccttctgcc ttcttcccat cgcagcacac   2271

 agccacctcc acttccaggg tctctgccct ttcactccaa ttacaccagg tcctgtagga   2331

 ggcttgtgaa agccaagtgc tgttctatgc aatatggttg tgtggactct gggtttgtaa   2391

 acactgcttt ggtagtctcc tcttcagacc tgctttgaag gaaagaccat cttgaatggt   2451

 atcagaacct cctacttctg gtaagtccaa aatccagagg gggagctcaa tggaactaaa   2511

 gattgaggtt cttgtcgagg aaaattttct tgctgctgta aggcagagtt caagacaatg   2571

 aaccagacgg tgctaagcag aaaaacgatt agtctgctat ttgggtgtga agagccaatg   2631

 tagatcccat tttaagaaag ctgaggaaag gtggttgagg aaacctatga agcagcaggt   2691

 ctatttccta ttaaaacaac ttgtccaaag gctgcctgca acaaattgct ttctatccat   2751

 ttctccatga gctccaattt ccacctctgc aggctttaat attcttacca agccagcagg   2811

 agggaaagcc attgcaacat cattcaatta ccctcaatat taaattcact tcccaaaaag   2871

 gatgagaagt caaccttgat gtgctcatat taaacagttt aaatccagaa gaaaacaaaa   2931

 aattctggac ttggattttt gaggttagaa agaatttttg aagcagaaat cccaataaat   2991

 atgctgatct tcctaagaat gaataaatca cagaatttta agccaaaagg aaagggcaca   3051

 taaagattat ccagtccaac ctcattttac aacgaaa                            3088




      <210> 490
      <211> 1097
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (14)..(820)

      <400> 490
 gcacgaggta gac   atg gcg gcc atc agg atg gga aaa ctg aca acc atg      49
                  Met Ala Ala Ile Arg Met Gly Lys Leu Thr Thr Met
                    1               5                  10

 cct gca ggt ctg ata tat gca tct gta agt gta cat gca gcc aaa caa       97
 Pro Ala Gly Leu Ile Tyr Ala Ser Val Ser Val His Ala Ala Lys Gln
          15                  20                  25

 gag gaa tcc aaa aag cag cta gtg aaa cca gag cag ctc ccc ata tat      145
 Glu Glu Ser Lys Lys Gln Leu Val Lys Pro Glu Gln Leu Pro Ile Tyr
      30                  35                  40

 act gca cca ccg ctc cag tct aaa tat gtt gaa gag cag cct ggt cat      193
 Thr Ala Pro Pro Leu Gln Ser Lys Tyr Val Glu Glu Gln Pro Gly His
  45                  50                  55                  60

 tta caa atg ggc ttt gct tcc atc cgc act gca act ggt tgt tac att      241
 Leu Gln Met Gly Phe Ala Ser Ile Arg Thr Ala Thr Gly Cys Tyr Ile
                  65                  70                  75

 ggc tgg tgc aag ggt gtt tat gtc ttt gtg aaa aat ggg ata atg gat      289
 Gly Trp Cys Lys Gly Val Tyr Val Phe Val Lys Asn Gly Ile Met Asp
              80                  85                  90

 aca gta caa ttt gga aaa gat gct tat gtc tat ctg aag aat cct cct      337
 Thr Val Gln Phe Gly Lys Asp Ala Tyr Val Tyr Leu Lys Asn Pro Pro
          95                 100                 105

 cga gat ttt ctt ccg aaa atg gga gtt att aca gtt tca gga ttg gcg      385
 Arg Asp Phe Leu Pro Lys Met Gly Val Ile Thr Val Ser Gly Leu Ala
     110                 115                 120

 ggc ttg gtt tca gcg aga aaa ggt tcc aag ttt aag aaa att act tat      433
 Gly Leu Val Ser Ala Arg Lys Gly Ser Lys Phe Lys Lys Ile Thr Tyr
 125                 130                 135                 140

 cct ctg gga ctg gcc act tta gga gca act gtt tgc tac cca gtt cag      481
 Pro Leu Gly Leu Ala Thr Leu Gly Ala Thr Val Cys Tyr Pro Val Gln
                 145                 150                 155

 tcc gta ata att gct aag gta aca gca aaa aag gta tat gct aca agc      529
 Ser Val Ile Ile Ala Lys Val Thr Ala Lys Lys Val Tyr Ala Thr Ser
             160                 165                 170

 cag caa att ttt gga gca gtt aaa tca ttg tgg aca aaa agc agc aaa      577
 Gln Gln Ile Phe Gly Ala Val Lys Ser Leu Trp Thr Lys Ser Ser Lys
         175                 180                 185

 gaa gag tca ctc cct aaa cct aaa gaa aaa act aag cta gga tcc tct      625
 Glu Glu Ser Leu Pro Lys Pro Lys Glu Lys Thr Lys Leu Gly Ser Ser
     190                 195                 200

 tcc gaa ata gaa gta cct gca aaa aca act cac gtc ttg aaa cac tca      673
 Ser Glu Ile Glu Val Pro Ala Lys Thr Thr His Val Leu Lys His Ser
 205                 210                 215                 220

 gtg ccc ttg cca aca gaa ctc agc tct gaa gca aag acc aaa tca gaa      721
 Val Pro Leu Pro Thr Glu Leu Ser Ser Glu Ala Lys Thr Lys Ser Glu
                 225                 230                 235

 tcc act tca ggt gca acc cag ttt atg cct gac ccc aag ctc atg gat      769
 Ser Thr Ser Gly Ala Thr Gln Phe Met Pro Asp Pro Lys Leu Met Asp
             240                 245                 250

 cac ggg cag tcc cac cca gaa gat ata gat atg tac agc act aga agc      817
 His Gly Gln Ser His Pro Glu Asp Ile Asp Met Tyr Ser Thr Arg Ser
         255                 260                 265

 tga agta gactgcatgc agagactaca cagaaaacta caagatgtgt ggcgttgcaa      874
 


 ataatgatga aaataaatca tgtaatgggt aactgataca tagagtatta cctaaaccaa    934

 gtttctccct tacatttcca aatatgccat ttgataaatt acataagtgg ttaacacaca    994

 aactgtgaat gcagtgtaaa caatattaaa tgattgatga ggagacttag gtagaagtat   1054

 tagcttgcat ttgatgacct ttaagggcac ttaaaaaaaa aaa                     1097




      <210> 491
      <211> 463
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (163)..(411)

      <400> 491
 ccgctttcaa agatcatggt cagtgtataa aaaagacagt taaatgtcca tggaacgtgt     60

 actgtccctc tccttcccct gaatcatggc cacaaagaaa tccttcaaaa gatcaaagaa    120

 aatggagata ttgaacaggt cacactctgt gatcatgatg ca   atg ggt ata gaa     174
                                                  Met Gly Ile Glu
                                                    1

 ata ata aca aga agg caa ttt aaa aaa ttt tac cca ctt gca aat tat      222
 Ile Ile Thr Arg Arg Gln Phe Lys Lys Phe Tyr Pro Leu Ala Asn Tyr
   5                  10                  15                  20

 gaa aca cac tca ctg ata acc ctg gaa tca aaa aga aaa cca aag aaa      270
 Glu Thr His Ser Leu Ile Thr Leu Glu Ser Lys Arg Lys Pro Lys Lys
                  25                  30                  35

 ata ttg aca tca tca ctt cca ttt tca ttg gaa gtg aaa gtt atc aga      318
 Ile Leu Thr Ser Ser Leu Pro Phe Ser Leu Glu Val Lys Val Ile Arg
              40                  45                  50

 aaa aaa aga caa aag aat att tca tta tca caa ctt cta agc aca gtg      366
 Lys Lys Arg Gln Lys Asn Ile Ser Leu Ser Gln Leu Leu Ser Thr Val
          55                  60                  65

 aaa gag gaa att ttc tat tcc tta cta aag aat aaa gaa aaa tag gac      414
 Lys Glu Glu Ile Phe Tyr Ser Leu Leu Lys Asn Lys Glu Lys 
      70                  75                  80

 aagtcattac tcagcttaag aaataaagag aaacaaaata aacctaaaa                463




      <210> 492
      <211> 1569
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (598)..(864)

      <400> 492
 gattttgaat agaagatatt atgaagattt ctcaagaagt tcctaaatct taaactttcc     60

 atgctgtctt taaaaatctt ttttttattt ttaagggaat aaaaatttta aaaattaaga    120

 gatatacaga tgacttttta agggtccttc tttccagcac atttttttta aaaactcagg    180

 ttagaataaa aatgtcataa agggcactaa aagtaacatt tgggtttcac tccatatcta    240

 gaagaattta gctcacaaaa caatttttgt gtgttttgag taactgatgc ataagtgcaa    300

 tgaataattt tcctgcttca ctgttatttt taatttaacc tggcaaatta agtgagactt    360

 gaacaaaatt ttgttcatct tgaagaatgt atagtggctt aggttatttg aggttttcgt    420

 tttgaatata tatgttgtta ttttgatgta gatacgttag cagatggaga ggttctaaga    480

 gattggatac tttggaatgt ctttatatag gaaatagacc tcccatttct taagcaagtt    540

 gcttctggaa ttgatgcaac agggatatta gctgtagttt aatggataag ttgttct       597                                                                 
 atg agc tgc tgc tat cag tac ttt ttt cca cat ttt cca ttg ata ttt      645
 Met Ser Cys Cys Tyr Gln Tyr Phe Phe Pro His Phe Pro Leu Ile Phe
   1               5                  10                  15

 gtg atg ctt gaa aaa tcc aaa ctt cac ttg gat aca ttt aat ttt atg      693
 Val Met Leu Glu Lys Ser Lys Leu His Leu Asp Thr Phe Asn Phe Met
              20                  25                  30

 cct ttt tct ctc tac ctc cca ctt ttc cta ggc acc ctt gca cat ttt      741
 Pro Phe Ser Leu Tyr Leu Pro Leu Phe Leu Gly Thr Leu Ala His Phe
          35                  40                  45

 gtt act gtg aag gac tat tgc cct gtt acc tca ctg ata aga aat ctc      789
 Val Thr Val Lys Asp Tyr Cys Pro Val Thr Ser Leu Ile Arg Asn Leu
      50                  55                  60

 aac tgt att cat tca gaa tgc ttt aag ctt agt cat aaa cta cat ttg      837
 Asn Cys Ile His Ser Glu Cys Phe Lys Leu Ser His Lys Leu His Leu
  65                  70                  75                  80

 cct atg gac ctt tgg tta ttt tgt taa tgttg tcattatatt taagacttat      889
 Pro Met Asp Leu Trp Leu Phe Cys 
                  85

 tgtaggaagt aattttaaat ctatttcata acctgttttg atctgtctgc atactgctat    949

 atgttaattt attacggcct tttacaattc acttgtcatc tgagattgtt ctagaaactg   1009

 atgaggaaag agtcgtacta accaaaatga atgggcaatt gacataacat tctatttcag   1069

 gtttccttgt acttggggag ccaaagcaca agatctaagg aaatcttatt cacatttgtc   1129

 cctcagagca tcttacccta agccacagag gtataaatag taagatgaga attgctcatt   1189

 gtctgactcc ttgcacagca tgaatttaat tctagttgga aacaaagtta gtgttgacta   1249

 ctggttacct taaagtattc accatactat atatttatta gaccatcttt cctctttgtt   1309

 tattcaagac tatgtactta taaaagagaa cctataagaa tgtgtagagt gaccaaatag   1369

 ggacaaagtg acatacctag agtttgctgc tcaaattttt ccactagcgt aaccctaaag   1429

 cagaggggca tgatgaaggg ggaaggggtt ctgagagcaa aatcagaatc agcctaccac   1489

 tgacatgaag tgtgttctgt ctttaaaatg taagtgaatt ttgcattctc tataataaaa   1549

 cttttaatat aaaaaaaaaa                                               1569




      <210> 493
      <211> 1381
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1031)..(1240)

      <400> 493
 tttcgtccag ccccgacacc ctccgggcgg ccggtcccca cgccctctca ctgcgccctc     60

 ggtccgcccc agatcatccg ccagctggag aacaacatcg agaagacaat gatcaagatc    120

 atcaccagcc agaacatcca cctgctgtat ttggacctgc tggattatct gaagacagtg    180

 ctggcaggat accccattga gctggacaag ctgcagaacc tcgtggtcaa ctactgctca    240

 gagctgtcgg atatgaagat catgtcccaa gatgccatga tgatcacgga tgaggtcaag    300

 aggaacatga ggcaaaggga ggcgtccttc atcgaggagc gccgggcaag ggagaaccgg    360

 ctcaaccagc agaagaagct gatcgacaag atccacacga aggagaccag cgagaagtac    420

 cgccggggcc agatggactt ggacttcccc tcgaacctga tgagcacgga gaccctgaaa    480

 ttgaggagaa aagagacctc cacagcagaa atggaatacc agtcgggcgt gactgctgtg    540

 gtggagaagg tcaagagtgc tgtacggtgc tctcacgtct gggacatcac tagccgcttc    600

 ctggcccaga ggaacacgga ggagaacctg gagctgcaga tggaggactg tgaggagcgg    660

 cgggtgcagc tgaaggccct ggtgaagcag ctggagctgg aggaggccgt gctcaagttc    720

 cgccagaagc ctagctccat caggtgcccc gggcttccgg ggctgcgggc cacccacccc    780

 agtctcacaa aggccccggg ctgcagccag gctgggagct gggagtatac ccactgccaa    840

 caagcctgtg tgtcccacag aggggccagg ggactccact tgcacacacc tgagcttctg    900

 agtccctgat tctggcacag cacccaactc aggactgggc tcctgggtgg cccaccatgg    960

 ctctcgggcc tgtgcccctc actgctgtgt ccctattgcc ttctgcagct tcaagtccgt   1020

 tgagaagaaa   atg aca gac atg cta aaa gag gaa gaa gag agg ctc cag    1069
              Met Thr Asp Met Leu Lys Glu Glu Glu Glu Arg Leu Gln
                1               5                  10

 ctg gcg cac agc aac atg acc aag ggc cag gag ctg ctg ctg acc atc     1117
 Leu Ala His Ser Asn Met Thr Lys Gly Gln Glu Leu Leu Leu Thr Ile
      15                  20                  25

 cag atg ggc atc gac aac ctc tat gtc cgg ctg atg ggc att acc ttg     1165
 Gln Met Gly Ile Asp Asn Leu Tyr Val Arg Leu Met Gly Ile Thr Leu
  30                  35                  40                  45

 cct gcg acc cag gta ccg gga gtg agg ctg agc tgc cac aca cca ggt     1213
 Pro Ala Thr Gln Val Pro Gly Val Arg Leu Ser Cys His Thr Pro Gly
                  50                  55                  60

 ccc tgg gca ggg cca gag ggg aga tga gaccc tcctcccggc ctacagagag     1265
 Pro Trp Ala Gly Pro Glu Gly Arg 
              65

 aagtggtgct ctccaacacc ctcgatttga acagcaagct ggcgtactgc gaggggaagc   1325

 tcacgtacct ggctgacaga gtgcagatgg tgtccaggac cgaggagggc tgtatt       1381




      <210> 494
      <211> 549
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(471)

      <400> 494
 cttctccctc gtttgtaaca ttgagatcct agtagcagtt acttcttagg gttgttagga     60

 tgacatgag    atg ggc gag ttg gcc atc tgc cac aca aga gtt ccc ttc     108
              Met Gly Glu Leu Ala Ile Cys His Thr Arg Val Pro Phe
                1               5                  10

 tca ctg cca tcc tct gcc cag ggt gtt ccc cag aat ctg cag ggc ccc      156
 Ser Leu Pro Ser Ser Ala Gln Gly Val Pro Gln Asn Leu Gln Gly Pro
      15                  20                  25

 att ggt cat ctt gct gtc tgc aca cct tcc tct ctc acc tct tgg cac      204
 Ile Gly His Leu Ala Val Cys Thr Pro Ser Ser Leu Thr Ser Trp His
  30                  35                  40                  45

 ttc cct caa aaa aga gag aag tgg agc aca gta aat aaa cgc cag cgt      252
 Phe Pro Gln Lys Arg Glu Lys Trp Ser Thr Val Asn Lys Arg Gln Arg
                  50                  55                  60

 ttt ctc cag ttc cca gca cct ctc cgg aac tgg atc ccc caa act cct      300
 Phe Leu Gln Phe Pro Ala Pro Leu Arg Asn Trp Ile Pro Gln Thr Pro
              65                  70                  75

 ctg tca ctt tct gtg tcc agc ggg ccc ctg ggg tcc ttc act gtc ttc      348
 Leu Ser Leu Ser Val Ser Ser Gly Pro Leu Gly Ser Phe Thr Val Phe
          80                  85                  90

 act ctg ctc agc ctg tgc gct tgg cct tgg tgc tgt agg gac tgt tat      396
 Thr Leu Leu Ser Leu Cys Ala Trp Pro Trp Cys Cys Arg Asp Cys Tyr
      95                 100                 105

 aag agc tgc tgt ccg atc ccc ata ttc aat ctc aca gcc cca ctt tgt      444
 Lys Ser Cys Cys Pro Ile Pro Ile Phe Asn Leu Thr Ala Pro Leu Cys
 110                 115                 120                 125

 gta cac aca cca gag cca tct tct taa aatca gatcctgtca ctcctctccc      496
 Val His Thr Pro Glu Pro Ser Ser 
                 130

 taaaatctac cagtggtcta ataaaatctt gaatttttag cataaaaaaa aaa           549




      <210> 495
      <211> 1812
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (394)..(1560)

      <400> 495
 actgaaactg ccgctgctga actcagcgta tccagtcccg cagctgacca atcggagctc     60

 gcccttccgg ggcccgcccc attccaggaa tcgacctccg caccggcctc gaaaattgac    120

 caatcggttg tgtagctccg ctcttagtcc cgcccccacg ctgaaactga cacttcggat    180

 cgccgagtaa cgctcaccag acgtcccggc cctgcccctc acctgaccaa tcaagacggc    240

 cggccgaggc ccctggaacg gctcaggcgg ctgcggctgc tacggcggcg catgctaggg    300

 gattctgccg ggtagaagag ctgggcctgg aacccagccc tgaggacatc ctgcggccca    360

 ggggcaagtg acacctgctg agagaggccc agg atg gtg gag gct gag gaa ctg     414
                                      Met Val Glu Ala Glu Glu Leu
                                        1               5

 gca cag ctg cgg ctg ctc aat ctg gag ctc ctg agg cag ctg tgg gtg      462
 Ala Gln Leu Arg Leu Leu Asn Leu Glu Leu Leu Arg Gln Leu Trp Val
          10                  15                  20

 ggg cag gat gct gtg cgg cgg tca gtg gcc agg gca gcc tcg gag tca      510
 Gly Gln Asp Ala Val Arg Arg Ser Val Ala Arg Ala Ala Ser Glu Ser
      25                  30                  35

 agc ctg gaa tcc agc agc agc tac aac tca gag act cca tcg acc cca      558
 Ser Leu Glu Ser Ser Ser Ser Tyr Asn Ser Glu Thr Pro Ser Thr Pro
  40                  45                  50                  55

 gag acg tcc tca act tcc ttg agc acc tcc tgc cca cgg ggc cgg tcc      606
 Glu Thr Ser Ser Thr Ser Leu Ser Thr Ser Cys Pro Arg Gly Arg Ser
                  60                  65                  70

 tcc gtg tgg ggc cca cca gat gcc tgt cga ggg gac ctc cgt gat gtg      654
 Ser Val Trp Gly Pro Pro Asp Ala Cys Arg Gly Asp Leu Arg Asp Val
              75                  80                  85

 gcc aga tcg ggg gtg gcc tct ctc cca cct gcc aat tgc cag cac cag      702
 Ala Arg Ser Gly Val Ala Ser Leu Pro Pro Ala Asn Cys Gln His Gln
          90                  95                 100

 gag tcc ctg ggc cga ccg aga ccc cac tca gca ccc tcg ctg ggc acc      750
 Glu Ser Leu Gly Arg Pro Arg Pro His Ser Ala Pro Ser Leu Gly Thr
     105                 110                 115

 tca agc ctg agg gac cca gag ccc tca ggg agg ctg ggt gat cca gga      798
 Ser Ser Leu Arg Asp Pro Glu Pro Ser Gly Arg Leu Gly Asp Pro Gly
 120                 125                 130                 135

 ccc cag gag gca cag acc ccg agg tcc atc ctg gct caa cag agc aag      846
 Pro Gln Glu Ala Gln Thr Pro Arg Ser Ile Leu Ala Gln Gln Ser Lys
                 140                 145                 150

 ctg tcc aag ccc agg gtg acc ttc tct gag gag tct gca gtt cct aag      894
 Leu Ser Lys Pro Arg Val Thr Phe Ser Glu Glu Ser Ala Val Pro Lys
             155                 160                 165

 agg agc tgg cgc ctc agg cca tac ctg ggc tat gac tgg att gca ggg      942
 Arg Ser Trp Arg Leu Arg Pro Tyr Leu Gly Tyr Asp Trp Ile Ala Gly
         170                 175                 180

 tct ctg gac acc agc tct tcc atc acc agc cag cct gag gcc ttc ttc      990
 Ser Leu Asp Thr Ser Ser Ser Ile Thr Ser Gln Pro Glu Ala Phe Phe
     185                 190                 195

 tcc aag ctg cag gag ttt cgg gaa acc aac aag gag gag tgt atc tgc     1038
 Ser Lys Leu Gln Glu Phe Arg Glu Thr Asn Lys Glu Glu Cys Ile Cys
 200                 205                 210                 215

 agc cat cct gaa ccc cag ttg cca ggc ctg cgt gag agc agt ggc agc     1086
 Ser His Pro Glu Pro Gln Leu Pro Gly Leu Arg Glu Ser Ser Gly Ser
                 220                 225                 230

 ggc gtg gag gaa gac cat gaa tgc gtg tac tgt tac cgt gtc aac cgg     1134
 Gly Val Glu Glu Asp His Glu Cys Val Tyr Cys Tyr Arg Val Asn Arg
             235                 240                 245

 cgc ctg ttc ccg gtg cct gtg gat ccc ggt acc ccc tgc cgc ctg tgc     1182
 Arg Leu Phe Pro Val Pro Val Asp Pro Gly Thr Pro Cys Arg Leu Cys
         250                 255                 260

 agg aca ccg cga gac cag cag ggc cct ggg acc ctg gcg cag cca gcg     1230
 Arg Thr Pro Arg Asp Gln Gln Gly Pro Gly Thr Leu Ala Gln Pro Ala
     265                 270                 275

 cac gtc agg gtg agc atc ccg ctg tcg atc ctg gag ccc ccg cac cgg     1278
 His Val Arg Val Ser Ile Pro Leu Ser Ile Leu Glu Pro Pro His Arg
 280                 285                 290                 295

 tac cac atc cac cgg cga aag agc ttt gac gcc tct gac aca ctg gcc     1326
 Tyr His Ile His Arg Arg Lys Ser Phe Asp Ala Ser Asp Thr Leu Ala
                 300                 305                 310

 ctg ccc cgg cac tgc ctg ctg ggc tgg gac att ttt cct ccg aag tct     1374
 Leu Pro Arg His Cys Leu Leu Gly Trp Asp Ile Phe Pro Pro Lys Ser
             315                 320                 325

 gag aaa agc tca gcc ccc agg aac ctg gac ctc tgg tcc tct gtc tcc     1422
 Glu Lys Ser Ser Ala Pro Arg Asn Leu Asp Leu Trp Ser Ser Val Ser
         330                 335                 340

 gct gag gcc cag cac cag aag ctg tcc ggc acc agc agc cct ttt cac     1470
 Ala Glu Ala Gln His Gln Lys Leu Ser Gly Thr Ser Ser Pro Phe His
     345                 350                 355

 ccg gcc tca cca atg cag atg ctg ccc ccg acc ccg acc tgg tca gtg     1518
 Pro Ala Ser Pro Met Gln Met Leu Pro Pro Thr Pro Thr Trp Ser Val
 360                 365                 370                 375

 ccc cag gtc cct cgg ccc cac gtc cca cgg cag aag ccc tga ggactga     1567
 Pro Gln Val Pro Arg Pro His Val Pro Arg Gln Lys Pro 
                 380                 385

 ctcctggggg agaacagcat tcccgccgcc tccagcctct cccctctggc aggcgcaccc   1627

 aggagatgga atcccctgcc cgcccagctc aggcccagct gtcctaggtt gggcaggtgg   1687

 gtggacccaa gcttgtctgc tgcctgagtt ccagagaggg aggaccctgg ggtggagggt   1747

 gagggattct gtggaagttt gtaaataaag ctcagtgctc tgcagctcaa aaaaaaaaaa   1807

 aaaaa                                                               1812




      <210> 496
      <211> 1538
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1259)..(1447)

      <400> 496
 ggggtttggt gtctgtgcct gagcagcgct ggagccggag ccggttcccg ggtcctgcgg     60

 ctgaggagcc cctccgctgt ccacggcccc taccggcggg gggcggctgg gtccctcggc    120

 ggagctcggg agatgtgact gcctgagggc ggtggtggtg tcagcgtccg gggccggggg    180

 agggggtgtc tcgggcagag acccccgggc ttggggcagc tgaggcggcc gggcctcctc    240

 tacacggggc ccgccttccg ctgtctgggc cgcgagagtc cttcgtccct tacagccccg    300

 ccccggcttt gggacactgc gggtggtctg tttcccccag cttgggacac cccgttttct    360

 gaggcgtgga agagcgtcgc cccggagtaa gctgcccgtg ccgcgccccg acagcttccc    420

 tcagccccaa gccgcccctt attccggatc ccggccccaa ctttggccac ggagcctccc    480

 attcaaatcc ctcccttgct gtcaaggggt ctccccttcc cccaaggtgg ctcccgcgag    540

 cctctaatgc cctgacttct tccaatgtca cctacggccc ccttagtctc agctcagcca    600

 aaaactttaa tgcaaaggaa aagtctggat tggttccaca ggccttttaa aaagcggact    660

 taaaagttgc tggcaatgca ttccttttcg tcagagtcga gggcaaactc gctgaaatct    720

 gggtgacccg tgtccttttc cggagagcaa agcagagaag cgagagcggc cactagttcg    780

 gcaggaaatt tgttggaaga tgaagaagct aagatagggg gttggtgact tccacaggaa    840

 aagttctgga ggagtagcca aagaccatca gcgtttcctt tatgtgtgag aattgaaatg    900

 actagcatta ttgacccttt tcagcatccc ctgtgaatat ttctgtttag gtttttcttc    960

 ttgaaaagaa attgttattc agcccgttta aaacaaatca agaaactttt gggtaacatt   1020

 gcaattacat gaaattgata accgcgaaaa taattggaac tcctgcttgc aagtgtcaac   1080

 ctaaaaaaag tgcttccttt tgttatggaa gatgtctttc tgtgattgac ttcaattgct   1140

 gacttgtgga gatgcagcga atgtgaaatc ccacgtatat gccatttccc tctacgctcg   1200

 ctgaccgttc tggaagatct tgaaccctct tctggaaagg ggtacctatt attacttt     1258                                                                 
 atg ggg cag cag cct gga aaa gta ctt ggg gac caa aga agg cca agc     1306
 Met Gly Gln Gln Pro Gly Lys Val Leu Gly Asp Gln Arg Arg Pro Ser
   1               5                  10                  15

 ttg cct gcc ctg cat ttt atc aaa gga gca ggg aag aag gaa tca tcg     1354
 Leu Pro Ala Leu His Phe Ile Lys Gly Ala Gly Lys Lys Glu Ser Ser
              20                  25                  30

 agg cat ggg ggt cca cac tgc aat gtt ttt gtg gaa cat ggt gag tgc     1402
 Arg His Gly Gly Pro His Cys Asn Val Phe Val Glu His Gly Glu Cys
          35                  40                  45

 ttt tca aaa ttt ctg ctc atg gtt ttc ctc atg cat tca tct tag gcc     1450
 Phe Ser Lys Phe Leu Leu Met Val Phe Leu Met His Ser Ser 
      50                  55                  60

 ttcaaggaac tttgaacaac agtacttgcg acagttcctt ccaattccac ttaataaatt   1510

 tgttactgta gttaaaaaaa aaaaaaaa                                      1538




      <210> 497
      <211> 2530
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1342)..(1692)

      <400> 497
 cctggggatc cccctaaact gtgaattctg ccctggacag ggctttgccc ttggaggatc     60

 cccaggtggc cttacccgtg attcttactc ggcatcctcc attccccaaa ctccctcctc    120

 cctgttaaat gtcaacctag acctggacct gggtgggagg aaactgtagc ctgagtgtcc    180

 acagggacac acgtgagcca cagggctaga agcacaggcc cgtcacccca ggaggaaaag    240

 cccagggtct ggggcagcag agccatcgca tcatgtttcc cagggcaact tgaggtctga    300

 cttttggctc cctcgcccta agaggctctt cctctctttt gctcatccac cttcacacca    360

 cttgtgagct gacccccagg aacagcttgg ctgttccacc agagcagagg gaatcattgc    420

 tggactggat ttcttctgga gggaagcacc atgaattaaa ggtgccagag ctccatgcat    480

 ggaaaagtgg cctgttggtt caacgtggtt tccttgtact tgatcctcct gaaatgagag    540

 attttcctga gatgactgag tatggagatt accaggcaga tgataccgaa atgcttaaag    600

 gggctgtggc tgaggctgta gcatctctgc tggaggtgag acactctggg aactgatttg    660

 acctcgaatg ctcctaaaag agaacttgat agcctgacag cagagaagta ttatttggtg    720

 gggagtctga gaaagcctgg cttgtattat ctgtccaaaa ggaagcctct tcatctcctg    780

 gtgccttggt tgactatttt ggaaataggc atatcaaggt tcctgattca gcactttgct    840

 cttttaataa caaatcgtcc aaagatctca aagtaagggt ttttttttta gcttccactc    900

 ttccgcagac ttggtcatcg acctattttt gttgaagaat gaaaggcaat gacaagttta    960

 acatatacaa attcgtgaat tcttgttcat tttgcattcc tgcagtcagt gctaatccgt   1020

 cgttcttaat caggagttct gccaggttta aggtcacctg cactcccagc caagtggtga   1080

 tgtatgcctc ccactctctg caaggttttc ctcattttta tattcattta ttcatcattc   1140

 attcattcac ctaactttca ttaaatagct gcaccatccc aggccctgtg cggagcatcg   1200

 ggaatacaaa gatgagataa aacattgtcc ctgcccccgg gggcttcaca tgccactgga   1260

 aacaacagac tcttaaacta acaattcaag caggcgccaa gtgctacgac agaggtgtga   1320

 ataaaagcat caggaaatcg g  atg gag aac cac cat tca ccc aag ggt cag    1371
                          Met Glu Asn His His Ser Pro Lys Gly Gln
                            1               5                  10

 agg agg ttt caa aga aaa ggt gtc att gga gca gtg ttt tgc aga atg     1419
 Arg Arg Phe Gln Arg Lys Gly Val Ile Gly Ala Val Phe Cys Arg Met
                  15                  20                  25

 agc cag agt tca cca agc agg caa ggc aag gaa ggg tgt tgc aga gag     1467
 Ser Gln Ser Ser Pro Ser Arg Gln Gly Lys Glu Gly Cys Cys Arg Glu
              30                  35                  40

 gga aca gca tat gca aag gca tat cag ttc atg gca tca cat ctt tca     1515
 Gly Thr Ala Tyr Ala Lys Ala Tyr Gln Phe Met Ala Ser His Leu Ser
          45                  50                  55

 ctg ggg aag cca gtt tcc aca ggc agc atc cca agg ttc aat aag gcc     1563
 Leu Gly Lys Pro Val Ser Thr Gly Ser Ile Pro Arg Phe Asn Lys Ala
      60                  65                  70

 tta ttt aac aag caa gca aaa tgc aaa cca aac cat tat tca ttt att     1611
 Leu Phe Asn Lys Gln Ala Lys Cys Lys Pro Asn His Tyr Ser Phe Ile
  75                  80                  85                  90

 ggc tta agt atg ctt tct cct gaa aac ttt agc att ggg tgc aaa tat     1659
 Gly Leu Ser Met Leu Ser Pro Glu Asn Phe Ser Ile Gly Cys Lys Tyr
                  95                 100                 105

 tca gta tgg ttc tcg gag tcc aaa ggg ttt taa gccagggc acaaccagaa     1710
 Ser Val Trp Phe Ser Glu Ser Lys Gly Phe 
             110                 115

 aagtggctct ctttggtagg gagaggggct ccaatatttc gttctctccc catggggcac   1770

 tgacagagaa atgaaatagt tttatctgga aaattccaga gctattattt actccttacc   1830

 aagggaagtt acttcttgta aaaactttta agccatttat caacaagttc ttgttgactc   1890

 agggcataat gagttcctga gacatgctct tttgggggct ggggctttag ctagaagaat   1950

 ttcaaggaaa agaattctca gcagagctca agattgtaga aactcagcag aagctggtaa   2010

 aaacatgggg agcccggagg acaggctgct gtccagggca gaggccatga agaagtgctt   2070

 ccgtggccga cagtctggaa atgaatccat catacattag tgccatagag tttagtaacc   2130

 gtccagcaag tgtcatcact tttacagaaa acaaggtcca gtaatagcaa gtcttagtac   2190

 atcctcactt ttattataaa tgggtgtttt ttcataattt ttactgacgc tcagtaacca   2250

 tgcaaaattg tgtatagcat taatgtatct acatacctac acctatctat atataagctc   2310

 atggtagaaa accatagcta agtagcatcg cagacttaag cgtacaaagt gatcttgttc   2370

 acaagtaatc tgttgacagt gccaataaat gataaaaaaa aaattaacat gtcacaatgt   2430

 aacggatgac catatgcaca attccatgaa ttaaatctgt ttcctgtgtt agtcagtatt   2490

 cttaaataaa atttataatt gaaacatgaa aaaaaaaaaa                         2530




      <210> 498
      <211> 1798
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (339)..(1061)

      <400> 498
 acgagggctg gcagagtgtt aacacggtgc cgggcagcgc tggctccagc tcacgaaaca     60

 gccccgggcg ccgcgccgct ctgagtccag cctcctactg agaacagtcc ctcccttgtg    120

 cgggtcgcac ggctagccgc aggttcggcc acgtcaaatc cattttctaa aaaagcaggg    180

 agcagagctc tctcttcgcc gccgacgcag aaaggagctg gggaggaaaa agctgctgcc    240

 ttttgcgctg gagattcgtg ggcaaggctt ctcattttcc caggctgctt cccctcccgg    300

 gtgaggagcg tcctgagact aaggaaagag cctggaaa    atg gag cag acc tgg     353
                                              Met Glu Gln Thr Trp
                                                1               5

 acg aga gat tat ttt gca gag ggt gat ggg gag atg gta ccc aga acg      401
 Thr Arg Asp Tyr Phe Ala Glu Gly Asp Gly Glu Met Val Pro Arg Thr
                  10                  15                  20

 agt cac aca gca gct ttt ctt agt gac act aaa gat cga ggc cct cca      449
 Ser His Thr Ala Ala Phe Leu Ser Asp Thr Lys Asp Arg Gly Pro Pro
              25                  30                  35

 gtg cag tca cag atc tgg aga agt ggt gaa aag gtc ccg ttt gtg cag      497
 Val Gln Ser Gln Ile Trp Arg Ser Gly Glu Lys Val Pro Phe Val Gln
          40                  45                  50

 aca tat tcc ttg aga gca ttt gag aaa ccc cct cag gta cag acc cag      545
 Thr Tyr Ser Leu Arg Ala Phe Glu Lys Pro Pro Gln Val Gln Thr Gln
      55                  60                  65

 gct ctt cga gac ttt gag aag cac ctc aat gac ctg aag aag gag aac      593
 Ala Leu Arg Asp Phe Glu Lys His Leu Asn Asp Leu Lys Lys Glu Asn
  70                  75                  80                  85

 ttc agc ctc aag ctg cgc atc tac ttc ctg gag gag cgc atg caa cag      641
 Phe Ser Leu Lys Leu Arg Ile Tyr Phe Leu Glu Glu Arg Met Gln Gln
                  90                  95                 100

 aag tat gag gcc agc cgg gag gac atc tac aag cgg aac act gag ctg      689
 Lys Tyr Glu Ala Ser Arg Glu Asp Ile Tyr Lys Arg Asn Thr Glu Leu
             105                 110                 115

 aag gtt gaa gtg gag agc ttg aaa cga gaa ctc cag gac aag aaa cag      737
 Lys Val Glu Val Glu Ser Leu Lys Arg Glu Leu Gln Asp Lys Lys Gln
         120                 125                 130

 cat ctg gat aaa aca tgg gct gat gtg gag aat ctc aac agt cag aat      785
 His Leu Asp Lys Thr Trp Ala Asp Val Glu Asn Leu Asn Ser Gln Asn
     135                 140                 145

 gaa gct gag ctc cga cgc cag ttt gag gag cga cag cag gag acg gag      833
 Glu Ala Glu Leu Arg Arg Gln Phe Glu Glu Arg Gln Gln Glu Thr Glu
 150                 155                 160                 165

 cat gtt tat gag ctc ttg gag aat aag atg cag ctt ctg cag gag gaa      881
 His Val Tyr Glu Leu Leu Glu Asn Lys Met Gln Leu Leu Gln Glu Glu
                 170                 175                 180

 tcc agg cta gca aag aat gaa gct gcg cgg atg gca gct ctg gtg gaa      929
 Ser Arg Leu Ala Lys Asn Glu Ala Ala Arg Met Ala Ala Leu Val Glu
             185                 190                 195

 gca gag aag gag tgt aac ctg gag ctc tca gag aaa ctg aag gga gtc      977
 Ala Glu Lys Glu Cys Asn Leu Glu Leu Ser Glu Lys Leu Lys Gly Val
         200                 205                 210

 acc aaa aac tgg gaa gat gta cca gga gac cag gtc aag ccc gac caa     1025
 Thr Lys Asn Trp Glu Asp Val Pro Gly Asp Gln Val Lys Pro Asp Gln
     215                 220                 225

 tac act gag gcc ctg gcc cag agg gac aag atc taa aaaa aataatgctg     1075
 Tyr Thr Glu Ala Leu Ala Gln Arg Asp Lys Ile 
 230                 235                 240

 ggaagtccta accacatcaa gaatgcctca gatcagtgac ccaaggacct tccagaatgg   1135

 atgaaataga cccaaagctg aattcaccta attttagggc caaaaaccca aaaaacaaaa   1195

 caagaccaaa aaaatcttca gatactggga gaacaaatct caattgctca attgtatctt   1255

 atgaaaacaa tttttcaaaa taaaacaaga gatatttaag attcattaag ttcttgtcat   1315

 tccaaatttt cacgaaaaat attttctaat gggaattaca ttatatttat atgattcttc   1375

 tagtaatatc catggtaata aatactcttt tcagtgtgga aataaaaacc cattgtgtgc   1435

 tatattatta gggaaaatat ctaccataaa ttagtttaaa tttacctaaa gtctatcttt   1495

 tgaattcata agcataaaat tttacaccac ttgcaaaatt tataaacaca ttaaaggtag   1555

 tcagatgcct ttgccaagta gtttaacaaa aagtgatttt cacctgtgtg ttttaataaa   1615

 ccagtgcatc gattttatga aactcagggc attgccttcg gcttcctaac aaagtatacg   1675

 aggctgaatg ggtctatggc caatatgcca ggtttacttt ctgagcctga ttatacttcg   1735

 gccccttttt accactggtc cagaatatta cagatacctc aaagggaggc cagtccctac   1795

 ctg                                                                 1798




      <210> 499
      <211> 812
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (360)..(581)

      <400> 499
 gagctcccag ctattctgtt cctgtttctg tcagctcctt ccctgaaaac tcagaggtgc     60

 tcagcatgcc atgctaaaag gcaaaataaa aaggcaaaac tcacagtggg aagagcataa    120

 tcagaaaaac acatgagggc aggatattct catcttttca aattctgcat gtgtatctat    180

 tagtggtcct agttcacctc ctcagctgtg ctgatgtcat gaaaaccagc cttgacctca    240

 caaactaccc cttgatgatg ctgaccgctg gactactaat atccaactgc ctgtgtcatt    300

 tcttcatctt tccttggtgc caaccatgcc tgcatatcag ggcagcattc tatgatccc     359                                                                 
 atg gct ctc aca tcg aca gac cac aac act aag cca aca atg ata cgg      407
 Met Ala Leu Thr Ser Thr Asp His Asn Thr Lys Pro Thr Met Ile Arg
   1               5                  10                  15

 cgt cca cca gca gtt gtt tgc tac att tgt ggt cgt gaa tat gga aca      455
 Arg Pro Pro Ala Val Val Cys Tyr Ile Cys Gly Arg Glu Tyr Gly Thr
              20                  25                  30

 aaa tct att agc att cat gag cca caa tgt ctg aaa aaa tgg cat aat      503
 Lys Ser Ile Ser Ile His Glu Pro Gln Cys Leu Lys Lys Trp His Asn
          35                  40                  45

 gaa aac aac ttg ttg cct aaa gag tta agg aga cca gta cct aaa aaa      551
 Glu Asn Asn Leu Leu Pro Lys Glu Leu Arg Arg Pro Val Pro Lys Lys
      50                  55                  60

 cca gaa gtc agg acc att act gac aaa taa g aaaaacagtt ctgaaatgcc      602
 Pro Glu Val Arg Thr Ile Thr Asp Lys 
  65                  70

 tgtccaaaga attatcttct gatgctgaga cataaagaca ctatgtcctg gcaacactgt    662

 gcatgagagg gacctatggg aatttgctgt attctccaaa agtttctttc atacatcatc    722

 aaaccctttg aatgtaaaat aaataataaa atacttaaaa aataaaaatg aataaaactt    782

 aaaaaaatat gaaacttaaa aaaaaaaaaa                                     812




      <210> 500
      <211> 800
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (360)..(749)

      <400> 500
 cgtttatgct tttgccacac atcttgtaac ttaatatact agatgttaag gttgttaatg     60

 tacaaaaaaa aaacccttat actcacctgc gttttcattt gtttgacatt tgtctattat    120

 tggattccat tatcatatga acttgtcagt gggaaacaaa ctgtctaaaa atttttctct    180

 tacgtttaac atacaatcat gtgaaattta ggcagagttc gataaattac tggcaaaaac    240

 aaaactcttt tataaagatt ttctaatgtt gactttaata ctctaacatg gtacaaacca    300

 aatggtaaaa tcccaagtca tttctttttt catctctatt tagcaacaga attaagtgg     359                                                                 
 atg aag ata ttc tac tat gca tta aat ctt gaa ctt tat aaa aca tgt      407
 Met Lys Ile Phe Tyr Tyr Ala Leu Asn Leu Glu Leu Tyr Lys Thr Cys
   1               5                  10                  15

 aca aaa att gta caa gat aag ttc cac ctg gta atg tct ttc cct aat      455
 Thr Lys Ile Val Gln Asp Lys Phe His Leu Val Met Ser Phe Pro Asn
              20                  25                  30

 aca ggg ttg cgc ttg cat tgg acc cta ggg att tgc act aaa att ata      503
 Thr Gly Leu Arg Leu His Trp Thr Leu Gly Ile Cys Thr Lys Ile Ile
          35                  40                  45

 tca agg tct cag atg agc tta gtg cac aag cac tat cac ttt aaa tac      551
 Ser Arg Ser Gln Met Ser Leu Val His Lys His Tyr His Phe Lys Tyr
      50                  55                  60

 tat tat ttg cta cca cag caa cta tat att tcc ata gct ttt ggc tgg      599
 Tyr Tyr Leu Leu Pro Gln Gln Leu Tyr Ile Ser Ile Ala Phe Gly Trp
  65                  70                  75                  80

 ggg cgg ggg aca ttt tta tta caa ctt gaa att gct ttg ctg gtt tca      647
 Gly Arg Gly Thr Phe Leu Leu Gln Leu Glu Ile Ala Leu Leu Val Ser
                  85                  90                  95

 tat tta ttt gtt gta ttt aaa aaa tac att gtt gta aga gtg att ttt      695
 Tyr Leu Phe Val Val Phe Lys Lys Tyr Ile Val Val Arg Val Ile Phe
             100                 105                 110

 tca ata tat ttt att cct ggg ggg gat cat gct aca ctc tca aaa gaa      743
 Ser Ile Tyr Phe Ile Pro Gly Gly Asp His Ala Thr Leu Ser Lys Glu
         115                 120                 125

 aat taa gaaatcattc agatcatccc ccctttttaa gtagtgtgaa ttgcaaaacc       799
 Asn 


 c                                                                    800




      <210> 501
      <211> 2246
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (610)..(1887)

      <400> 501
 tggcagcagg agacatataa cagctcctca gaatgcatag cgatgacggc tggaactaag     60

 gccacaactg gagagatgtt atggagatag tcagctatac ttggtgactt atttgataca    120

 ggagggagga catatagaga agactctggc aagcatcttt ggtgctgatc tctagagcac    180

 tcattaggtg gccttgatct ttgtagcata tgaggtcttt gaagtatccc agggtgggat    240

 ttcctggaag agggcaatga aagaagttga ggtggggccc tgtcagcagt ggtcctatcc    300

 ccagtcagag taatgggagt gcagtgcagg gagcttcaag cagagaggta gagccataga    360

 gagctaggga gaggccagaa cctcccagct taaagcccct cagacttgta tttgcttcca    420

 gcttcaagtc tggatagtca gaagtttgtg acagtgccct ccagtaatga agtggtaact    480

 aacctggaag tgctgacaag caaatgcctc catgggaaga actactggcg acaggtcctc    540

 tgtctgtatg atcttgccaa ggagttgggc tgttcctaca cagatgttgc tgctcaggat    600

 ggtgaagcc    atg ctc cgg aaa atc ttg gcc tct cag cag cct gac cga     648
              Met Leu Arg Lys Ile Leu Ala Ser Gln Gln Pro Asp Arg
                1               5                  10

 tgc aaa cga gcc cag gcc ttc atc agc aca cag ggc ctt aag cca gat      696
 Cys Lys Arg Ala Gln Ala Phe Ile Ser Thr Gln Gly Leu Lys Pro Asp
      15                  20                  25

 act gtg gct gaa ctc gtg gca gaa gag gtg aca cgg gag ctg ctt act      744
 Thr Val Ala Glu Leu Val Ala Glu Glu Val Thr Arg Glu Leu Leu Thr
  30                  35                  40                  45

 tca tca cag gga aca gga cat aag cag atg ttc aac cca aca gag gaa      792
 Ser Ser Gln Gly Thr Gly His Lys Gln Met Phe Asn Pro Thr Glu Glu
                  50                  55                  60

 agc cag aca ttt ctt cag ctg acc act ctg tgt caa gac cgc aca ttg      840
 Ser Gln Thr Phe Leu Gln Leu Thr Thr Leu Cys Gln Asp Arg Thr Leu
              65                  70                  75

 gta ggc atg aag ttg ttg gat aag att tcc tcc gtt ccc cat ggg gaa      888
 Val Gly Met Lys Leu Leu Asp Lys Ile Ser Ser Val Pro His Gly Glu
          80                  85                  90

 ctg tct tgc acc aca gag ctc ctg atc ctg gcc cat cat tgc ttc acc      936
 Leu Ser Cys Thr Thr Glu Leu Leu Ile Leu Ala His His Cys Phe Thr
      95                 100                 105

 ctg acg tgc cac atg gag ggc atc atc cga gtc cta cag gcc gcc cac      984
 Leu Thr Cys His Met Glu Gly Ile Ile Arg Val Leu Gln Ala Ala His
 110                 115                 120                 125

 atg ctc aca gat aac cac ctg gcc ccc agt gag gag tat ggg ctg gtg     1032
 Met Leu Thr Asp Asn His Leu Ala Pro Ser Glu Glu Tyr Gly Leu Val
                 130                 135                 140

 gta cgg ctc ctc act ggc att gga agg tac aac gag atg aca tac ata     1080
 Val Arg Leu Leu Thr Gly Ile Gly Arg Tyr Asn Glu Met Thr Tyr Ile
             145                 150                 155

 ttt gat ttg ctg cat aaa aag cac tac ttt gaa gtg cta atg agg aag     1128
 Phe Asp Leu Leu His Lys Lys His Tyr Phe Glu Val Leu Met Arg Lys
         160                 165                 170

 aag ttg gat ccg agt ggt acc ctg aaa aca gcc ctg ctg gac tac atc     1176
 Lys Leu Asp Pro Ser Gly Thr Leu Lys Thr Ala Leu Leu Asp Tyr Ile
     175                 180                 185

 aaa cgc tgc cgt cct gga gac agt gaa aag cac aat atg att gcc ctg     1224
 Lys Arg Cys Arg Pro Gly Asp Ser Glu Lys His Asn Met Ile Ala Leu
 190                 195                 200                 205

 tgc ttc agc atg tgc cgg gag att ggc gag aac cac gag gca gct gcc     1272
 Cys Phe Ser Met Cys Arg Glu Ile Gly Glu Asn His Glu Ala Ala Ala
                 210                 215                 220

 cgc atc caa ctg aaa ttg att gag tct cag ccc tgg gag gac agc ctc     1320
 Arg Ile Gln Leu Lys Leu Ile Glu Ser Gln Pro Trp Glu Asp Ser Leu
             225                 230                 235

 aag gat ggg cac cag ctg aaa caa ctg ctg ctg aag gcc ctg act ctg     1368
 Lys Asp Gly His Gln Leu Lys Gln Leu Leu Leu Lys Ala Leu Thr Leu
         240                 245                 250

 atg ttg gat gca gca gag agt tat gcc aag gac tcc tgt gtg cga cag     1416
 Met Leu Asp Ala Ala Glu Ser Tyr Ala Lys Asp Ser Cys Val Arg Gln
     255                 260                 265

 gcc cag cac tgt cag cgg ctc acc aag ttg ata act ctg cag att cac     1464
 Ala Gln His Cys Gln Arg Leu Thr Lys Leu Ile Thr Leu Gln Ile His
 270                 275                 280                 285

 ttt ctg aac act ggc cag aac aca atg ctc atc aac ttg ggc cgc cac     1512
 Phe Leu Asn Thr Gly Gln Asn Thr Met Leu Ile Asn Leu Gly Arg His
                 290                 295                 300

 aag ctg atg gac tgt att ctg gcc cta cct cgg ttc tac cag gct tct     1560
 Lys Leu Met Asp Cys Ile Leu Ala Leu Pro Arg Phe Tyr Gln Ala Ser
             305                 310                 315

 att gtg gct gag gcc tac gat ttt gtt cca gat tgg gct gaa att tta     1608
 Ile Val Ala Glu Ala Tyr Asp Phe Val Pro Asp Trp Ala Glu Ile Leu
         320                 325                 330

 tac cag caa gtg att ctt aaa gga gac ttt aat tac ttg gaa gaa ttt     1656
 Tyr Gln Gln Val Ile Leu Lys Gly Asp Phe Asn Tyr Leu Glu Glu Phe
     335                 340                 345

 aag cag caa agg tta tta aag tcc agt ata ttt gaa gag att tcc aaa     1704
 Lys Gln Gln Arg Leu Leu Lys Ser Ser Ile Phe Glu Glu Ile Ser Lys
 350                 355                 360                 365

 aaa tat aaa caa cat cag cct act gac atg gtc atg gaa aac ctg aag     1752
 Lys Tyr Lys Gln His Gln Pro Thr Asp Met Val Met Glu Asn Leu Lys
                 370                 375                 380

 aaa tta ctc aca tat tgt gaa gat gtt tac ctg tat tac aag ttg gca     1800
 Lys Leu Leu Thr Tyr Cys Glu Asp Val Tyr Leu Tyr Tyr Lys Leu Ala
             385                 390                 395

 tac gaa cac aag ttt tat gaa att gta aat gtg ctt ctg aag gac cct     1848
 Tyr Glu His Lys Phe Tyr Glu Ile Val Asn Val Leu Leu Lys Asp Pro
         400                 405                 410

 cag aca ggt tgc tgt cta aag gac atg cta gca ggt tag atgatttcat      1897
 Gln Thr Gly Cys Cys Leu Lys Asp Met Leu Ala Gly 
     415                 420                 425

 aggtgtctgt tttcttgtac tgttagcaga ttctgacaga tgtgatgaga agaagaatgc   1957

 attggagatc tttgctaaag ttgaacaatc ccggtactgt accatatcag tcctttgtgg   2017

 gtagtaggta gcaagtaaga aacttttcag gaggaaattc ctatttaaaa tagattgatt   2077

 ttagatgatt gttcatccac accattttat atagatacta gtattaagat caaaagcttc   2137

 ctcttcctca ggacagcttc tactttagat gatccaataa tgattaaagc aatgatgata   2197

 taaggatggc agattaagta tatggaaagg tgctccacat cactatggg               2246




      <210> 502
      <211> 845
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (345)..(794)

      <400> 502
 tttcgtggaa ggtctccggc cccaggcgcg gcgcgcgggg cttctgccca gtttcctgct     60

 tctcagccgc ggtgtctgcc ccggcccaga gccagtctgt gcaatttaga aactcgatag    120

 gaggcagcag ctggtctccc accaccctaa aaataatccg ttccggcgca ctgcgtgctt    180

 cgcctagggg aggaaaactg tcatcggaga gttctgcgtc cgggtttgaa atttacatct    240

 taagacagtg taggaagtcg gtgttttgaa ggtagctcaa gtgcaccggc aggggtttga    300

 agcagcgtga agctattgcc caagagtaaa ccatataaga agaa atg agc ctt tca     356
                                                  Met Ser Leu Ser
                                                    1

 ttt tgt ggt aac aac att tct tca tat aat atc aac gat ggt gta cta      404
 Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn Asp Gly Val Leu
   5                  10                  15                  20

 caa aat tcc tgc ttt gtg gat gcc ctc aac ctg gtc cct cat gtc ttt      452
 Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val Pro His Val Phe
                  25                  30                  35

 ctg ttg ttt atc act ttt cca ata ttg ttt att ggg tgg ggg agc caa      500
 Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe Ile Gly Trp Gly Ser Gln
              40                  45                  50

 agc tca aaa gta caa att cac cac aac aca tgg ctt cat ttt ccg gga      548
 Ser Ser Lys Val Gln Ile His His Asn Thr Trp Leu His Phe Pro Gly
          55                  60                  65

 cat aac ctg aga tgg att ctt aca ttc gct ctc ctg ttt gtg cat gtc      596
 His Asn Leu Arg Trp Ile Leu Thr Phe Ala Leu Leu Phe Val His Val
      70                  75                  80

 tgt gaa ata gca gaa ggc att gtt tca gac tcg cgg cgg gaa tca agg      644
 Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg Arg Glu Ser Arg
  85                  90                  95                 100

 cac ctc cac ctc ttt atg cca gcc gtg atg gga ttc gtt gcc act aca      692
 His Leu His Leu Phe Met Pro Ala Val Met Gly Phe Val Ala Thr Thr
                 105                 110                 115

 aca tcg ata gtg tat tat cat aat atc gaa aca tca aat ttt cct aaa      740
 Thr Ser Ile Val Tyr Tyr His Asn Ile Glu Thr Ser Asn Phe Pro Lys
             120                 125                 130

 tta ctt tta ggt ttt agc cat cat gag agt aaa agc tgc tat caa cat      788
 Leu Leu Leu Gly Phe Ser His His Glu Ser Lys Ser Cys Tyr Gln His
         135                 140                 145

 tct taa gtattttgtg gctatatgca tttatttctc ctaggtaaat acctaagagt       844
 Ser 


 g                                                                    845




      <210> 503
      <211> 2484
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (149)..(2440)

      <400> 503
 gaccgccaac ttttttttta ccaaacattt taaagatgtt ggaagatcca tatgctgcct     60

 ggaggctgtt tgtttctagg gacacaagta tccagcctat attgttacaa ttttttttca    120

 agaactgccg tcttctttgc ctgcacta   atg gaa cat cat ctt cag cgg gct     172
                                  Met Glu His His Leu Gln Arg Ala
                                    1               5

 att tca gca cag cag gtg tat ggc gag aag agg gat aat atg gtt ata      220
 Ile Ser Ala Gln Gln Val Tyr Gly Glu Lys Arg Asp Asn Met Val Ile
      10                  15                  20

 ccg gtc cca gag gca gaa agt aat att gct tac tat gag tct ata tat      268
 Pro Val Pro Glu Ala Glu Ser Asn Ile Ala Tyr Tyr Glu Ser Ile Tyr
  25                  30                  35                  40

 cct ggg gaa ttt aag atg cca aag cag ctc att cac ata cag cct ttt      316
 Pro Gly Glu Phe Lys Met Pro Lys Gln Leu Ile His Ile Gln Pro Phe
                  45                  50                  55

 agt ttg gat gct gaa cag cct gat tat gat ttg gat tct gaa gat gaa      364
 Ser Leu Asp Ala Glu Gln Pro Asp Tyr Asp Leu Asp Ser Glu Asp Glu
              60                  65                  70

 gta ttt gtg aat aaa ctg aaa aag aaa atg gac atc tgc cca ttg caa      412
 Val Phe Val Asn Lys Leu Lys Lys Lys Met Asp Ile Cys Pro Leu Gln
          75                  80                  85

 ttt gag gag atg att gac cgc cta gaa aaa ggc agt ggt cag cag cca      460
 Phe Glu Glu Met Ile Asp Arg Leu Glu Lys Gly Ser Gly Gln Gln Pro
      90                  95                 100

 gtc agt ctg cag gaa gcc aaa cta ctg cta aaa gaa gat gat gaa cta      508
 Val Ser Leu Gln Glu Ala Lys Leu Leu Leu Lys Glu Asp Asp Glu Leu
 105                 110                 115                 120

 att aga gaa gtt tat gaa tat tgg att aaa aag aga aaa aac tgt cga      556
 Ile Arg Glu Val Tyr Glu Tyr Trp Ile Lys Lys Arg Lys Asn Cys Arg
                 125                 130                 135

 ggg cca tct ctt att cca tca gta aaa caa gag aag cga gat ggt tcc      604
 Gly Pro Ser Leu Ile Pro Ser Val Lys Gln Glu Lys Arg Asp Gly Ser
             140                 145                 150

 agc aca aat gat cct tat gtg gct ttt aga agg cgt act gaa aaa atg      652
 Ser Thr Asn Asp Pro Tyr Val Ala Phe Arg Arg Arg Thr Glu Lys Met
         155                 160                 165

 cag act cga aaa aat cgc aaa aat gat gaa gcc tct tac gaa aaa atg      700
 Gln Thr Arg Lys Asn Arg Lys Asn Asp Glu Ala Ser Tyr Glu Lys Met
     170                 175                 180

 ctt aag ctg cga cga gat cta agt cga gct gtt act att cta gag atg      748
 Leu Lys Leu Arg Arg Asp Leu Ser Arg Ala Val Thr Ile Leu Glu Met
 185                 190                 195                 200

 ata aaa aga aga gaa aaa agt aaa aga gag cta ttg cac tta aca ctg      796
 Ile Lys Arg Arg Glu Lys Ser Lys Arg Glu Leu Leu His Leu Thr Leu
                 205                 210                 215

 gaa att atg gaa aag agg tat aat ttg ggc gac tac aat gga gag atc      844
 Glu Ile Met Glu Lys Arg Tyr Asn Leu Gly Asp Tyr Asn Gly Glu Ile
             220                 225                 230

 atg tct gag gtt atg gca cag aga cag cca atg aaa cct act tat gcc      892
 Met Ser Glu Val Met Ala Gln Arg Gln Pro Met Lys Pro Thr Tyr Ala
         235                 240                 245

 atc ccc atc atc cct att act aat agc agt caa ttt aaa cac cag gaa      940
 Ile Pro Ile Ile Pro Ile Thr Asn Ser Ser Gln Phe Lys His Gln Glu
     250                 255                 260

 gca atg gat gtg aag gag ttc aaa gtt aat aag caa gat aaa gcc gat      988
 Ala Met Asp Val Lys Glu Phe Lys Val Asn Lys Gln Asp Lys Ala Asp
 265                 270                 275                 280

 ctt atc cga ccg aaa cgg aaa tat gaa aag aag ccc aaa gtc tta cca     1036
 Leu Ile Arg Pro Lys Arg Lys Tyr Glu Lys Lys Pro Lys Val Leu Pro
                 285                 290                 295

 tcg tct gcc gct gct act ccc caa cag acg agt cct gct gca ctg cca     1084
 Ser Ser Ala Ala Ala Thr Pro Gln Gln Thr Ser Pro Ala Ala Leu Pro
             300                 305                 310

 gtc ttc aat gct aaa gat ctg aat cag tat gac ttt ccc agc tca gac     1132
 Val Phe Asn Ala Lys Asp Leu Asn Gln Tyr Asp Phe Pro Ser Ser Asp
         315                 320                 325

 gaa gaa cct ctc tcc cag gtt ttg tct ggc tct tcg gaa gct gag gaa     1180
 Glu Glu Pro Leu Ser Gln Val Leu Ser Gly Ser Ser Glu Ala Glu Glu
     330                 335                 340

 gac aat gat cct gat ggt cct ttt gct ttc cgt agg aaa gca ggc tgt     1228
 Asp Asn Asp Pro Asp Gly Pro Phe Ala Phe Arg Arg Lys Ala Gly Cys
 345                 350                 355                 360

 cag tac tat gct cct cac tta gac caa act ggc aac tgg cct tgg act     1276
 Gln Tyr Tyr Ala Pro His Leu Asp Gln Thr Gly Asn Trp Pro Trp Thr
                 365                 370                 375

 agt cct aaa gat gga gga tta ggg gat gtg cga tat aga tac tgc tta     1324
 Ser Pro Lys Asp Gly Gly Leu Gly Asp Val Arg Tyr Arg Tyr Cys Leu
             380                 385                 390

 act act ctc acc gta ccc caa agg tgt att gga ttt gca cga aga cgg     1372
 Thr Thr Leu Thr Val Pro Gln Arg Cys Ile Gly Phe Ala Arg Arg Arg
         395                 400                 405

 gtt ggg cgc ggt gga agg gtc tta ctg gac aga gct cat tca gac tat     1420
 Val Gly Arg Gly Gly Arg Val Leu Leu Asp Arg Ala His Ser Asp Tyr
     410                 415                 420

 gac agt gtg ttt cac cat ctg gat ttg gaa atg ctt tcc tca cca caa     1468
 Asp Ser Val Phe His His Leu Asp Leu Glu Met Leu Ser Ser Pro Gln
 425                 430                 435                 440

 cat tct cca gtc aat cag ttt gcc aat acc tca gaa aca aat acc tcg     1516
 His Ser Pro Val Asn Gln Phe Ala Asn Thr Ser Glu Thr Asn Thr Ser
                 445                 450                 455

 gac aaa tct ttc tct aaa gac ctc agt cag ata cta gtc aat atc aaa     1564
 Asp Lys Ser Phe Ser Lys Asp Leu Ser Gln Ile Leu Val Asn Ile Lys
             460                 465                 470

 tca tgt aga tgg cgg cat ttt agg cct cgg aca cca tcc cta cat gac     1612
 Ser Cys Arg Trp Arg His Phe Arg Pro Arg Thr Pro Ser Leu His Asp
         475                 480                 485

 agt gac aat gat gaa ctc tcc tgt aga aaa tta tat agg agt ata aac     1660
 Ser Asp Asn Asp Glu Leu Ser Cys Arg Lys Leu Tyr Arg Ser Ile Asn
     490                 495                 500

 cga aca gga aca gca caa cct ggg acc cag aca tgc agt acc tct acg     1708
 Arg Thr Gly Thr Ala Gln Pro Gly Thr Gln Thr Cys Ser Thr Ser Thr
 505                 510                 515                 520

 caa agt aaa agt agc agt ggt tca gca cac ttt gca ttt aca gcc gaa     1756
 Gln Ser Lys Ser Ser Ser Gly Ser Ala His Phe Ala Phe Thr Ala Glu
                 525                 530                 535

 caa tac cag caa cat caa cag caa ctg gca ctc atg cag aaa cag cag     1804
 Gln Tyr Gln Gln His Gln Gln Gln Leu Ala Leu Met Gln Lys Gln Gln
             540                 545                 550

 ctt gca caa att cag caa cag caa gca aat agt aat tcc tcc acc aac     1852
 Leu Ala Gln Ile Gln Gln Gln Gln Ala Asn Ser Asn Ser Ser Thr Asn
         555                 560                 565

 aca tca cag ggt ttt gtt tct aag act ttg gat tct gct agt gca cag     1900
 Thr Ser Gln Gly Phe Val Ser Lys Thr Leu Asp Ser Ala Ser Ala Gln
     570                 575                 580

 ttt gct gct tct gct ttg gtg aca tca gaa caa ctg atg gga ttc aag     1948
 Phe Ala Ala Ser Ala Leu Val Thr Ser Glu Gln Leu Met Gly Phe Lys
 585                 590                 595                 600

 atg aag gat gat gtg gtg ctt gga atc ggg gtg aat ggc gtc ctt cca     1996
 Met Lys Asp Asp Val Val Leu Gly Ile Gly Val Asn Gly Val Leu Pro
                 605                 610                 615

 gcc tca gga gta tac aag ggc tta cac ctc agt agt act aca cca aca     2044
 Ala Ser Gly Val Tyr Lys Gly Leu His Leu Ser Ser Thr Thr Pro Thr
             620                 625                 630

 gca ctt gta cat aca agt cca tca acg gca ggt tca gct ttg tta cag     2092
 Ala Leu Val His Thr Ser Pro Ser Thr Ala Gly Ser Ala Leu Leu Gln
         635                 640                 645

 cct tca aat att aca cag act tca agt tcc cac agt gca ctg agt cat     2140
 Pro Ser Asn Ile Thr Gln Thr Ser Ser Ser His Ser Ala Leu Ser His
     650                 655                 660

 caa gta act gct gcc aat tct gca aca act cag gtt ctg att ggg aac     2188
 Gln Val Thr Ala Ala Asn Ser Ala Thr Thr Gln Val Leu Ile Gly Asn
 665                 670                 675                 680

 aac att cga tta act gta cct tca tca gtt gcc act gta aac tct att     2236
 Asn Ile Arg Leu Thr Val Pro Ser Ser Val Ala Thr Val Asn Ser Ile
                 685                 690                 695

 gcc cca ata aat gca cga cat ata cct agg act tta agt gct gtt cca     2284
 Ala Pro Ile Asn Ala Arg His Ile Pro Arg Thr Leu Ser Ala Val Pro
             700                 705                 710

 tca tct gcc tta aag ctg gcc gct gca gca aac tgt caa gtt tcc aag     2332
 Ser Ser Ala Leu Lys Leu Ala Ala Ala Ala Asn Cys Gln Val Ser Lys
         715                 720                 725

 gtc cca tct tca tcc tct gta gat tca gtt cca agg gaa aat cat gaa     2380
 Val Pro Ser Ser Ser Ser Val Asp Ser Val Pro Arg Glu Asn His Glu
     730                 735                 740

 tca gaa aag cca gca ctg aac aac ata gca gac aac aca gta gcg atg     2428
 Ser Glu Lys Pro Ala Leu Asn Asn Ile Ala Asp Asn Thr Val Ala Met
 745                 750                 755                 760

 gag gtg acg tag ctt cctccgagtg gaactgcagc ctggggactt gattaggtgc     2483
 Glu Val Thr 


 t                                                                   2484




      <210> 504
      <211> 975
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (321)..(533)

      <400> 504
 tttcgtggga gatgcagcgc gcggcgatgg acagagcggg atgccaccag cttgtccaaa     60

 gggaagttcc aggagctcct ggtgggcatc gttgtggaga atgacgctgg ccgcggcgag    120

 atcaacgagt tgaagcaggt ggaaggggag gcttcgtgca gcagccgcaa aggaaagctg    180

 attttcttct atgagtggaa catcaaactg ggctggaaag gcatcgttaa agaatctgga    240

 gtgaagcaca agggattgat tgaaataccc aatctttctg aggaaaatga agtagatgac    300

 actgagaatt tacaacggga    atg att tta cca acg aaa gct atg gca acc     350
                          Met Ile Leu Pro Thr Lys Ala Met Ala Thr
                            1               5                  10

 cag gaa ttg act gtc aaa aga aaa ctg agt ggg aat acc ctg cag gtt      398
 Gln Glu Leu Thr Val Lys Arg Lys Leu Ser Gly Asn Thr Leu Gln Val
                  15                  20                  25

 cag gcc tca tct cca gtg gca ctg ggt gta agg att ccc act gtg gct      446
 Gln Ala Ser Ser Pro Val Ala Leu Gly Val Arg Ile Pro Thr Val Ala
              30                  35                  40

 ctt cac atg atg gaa ctg ttt gac aca act gta gag cag ctg tat agc      494
 Leu His Met Met Glu Leu Phe Asp Thr Thr Val Glu Gln Leu Tyr Ser
          45                  50                  55

 atc ttc act gta aag gag gta agt aac tcc cta agc tag catgttaagt       543
 Ile Phe Thr Val Lys Glu Val Ser Asn Ser Leu Ser 
      60                  65                  70

 gctgacattg ggagaaaata cattacaaag aacaggagct ggtttttggt tttccttgtg    603

 gctgtgtttt tgattgaagg gatgtgggat ggtggtgaca gaagtctgag catagtttct    663

 gaataattgg aggggagatg ggcattcttt gggactatgt ccgcattaca ttgagttttc    723

 tccctctagg aagagagagt ttgtgtttta ttttctgtaa gtaaaagcta catgtttagg    783

 atttttaaac catattaatt gttatatttt gtatttcata attatattat gtgttagtgt    843

 gtactggaat aacatgtttt atttggttag ttggtgcaaa gttttctaaa tctactgctg    903

 tattagaaac tgaaaaggga gggaaattcc agatgtttga taggacatca ctggtgatat    963

 ctaggattat ag                                                        975




      <210> 505
      <211> 783
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (163)..(417)

      <400> 505
 ggcgtaggcg gaggagattt tcggacctgc gacttccgaa caaccctggc aggaggagcg     60

 gcgttcagcc gggggaggcc tgaagaaacg ctccggggcc cagtggctct acccctgctc    120

 ctgcccgacc ctgccgcctc cctcacggag ccagcggccg ga   atg cag aca tca     174
                                                  Met Gln Thr Ser
                                                    1

 gaa cgt gag ggg agt ggg ccg gag ctg agc ccc agc gtg atg ccc gag      222
 Glu Arg Glu Gly Ser Gly Pro Glu Leu Ser Pro Ser Val Met Pro Glu
   5                  10                  15                  20

 gct ccc ctg gag tct cca cct ttt cct acc aag tcc cca gcg ttt gac      270
 Ala Pro Leu Glu Ser Pro Pro Phe Pro Thr Lys Ser Pro Ala Phe Asp
                  25                  30                  35

 ctt ttc aac ttg gtt ctc tcc tac aag agg ctg gag atc tac ctg gaa      318
 Leu Phe Asn Leu Val Leu Ser Tyr Lys Arg Leu Glu Ile Tyr Leu Glu
              40                  45                  50

 ccc ttg aag gat gca ggt gat ggt gtt cga tac ttg ctc agg tac aga      366
 Pro Leu Lys Asp Ala Gly Asp Gly Val Arg Tyr Leu Leu Arg Tyr Arg
          55                  60                  65

 ctt tgt gga gtt gct ctg gtc tgc tct gcc ttc tgc cgt cct gct ctg      414
 Leu Cys Gly Val Ala Leu Val Cys Ser Ala Phe Cys Arg Pro Ala Leu
      70                  75                  80

 tag taac taacactgac catttaggca gtggctgggc tgtcctttct gccctagtga      471
 


 ggagcagttc tgggaggtct gttcggcctc tgggtttatc taggcctacc ctgtgtctca    531

 ggcccagccc aggagaggca gatactggga atgatcctgc ctttcagcaa ggttcttctt    591

 tgtgactgaa taagctcctt cctctggact gctggacaac cttgaacatc acgccttcta    651

 cagcttagag caggcttaat tttttccttt gcccccaata ttagcataat taatattaaa    711

 aaattagggt ataattttga acaaaaatta aagaaataca aaaacctgtg aataagcaga    771

 taccattttc ac                                                        783




      <210> 506
      <211> 539
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (167)..(463)

      <400> 506
 ggcgtaggcg gaggagattt tcggacctgc gacttccgaa caaccctggc aggaggagcg     60

 gcgttcagcc gggggaggcc tgaagaaacg ctccggggcc cagtggctct acccctgctc    120

 ctgcccgacc ctgccgcctc cctcacggag ccagcggccg ggtagg   atg cag aca     175
                                                      Met Gln Thr
                                                        1

 tca gaa cgt gag ggg agt ggg ccg gag ctg agc ccc agc gtg atg ccc      223
 Ser Glu Arg Glu Gly Ser Gly Pro Glu Leu Ser Pro Ser Val Met Pro
       5                  10                  15

 gag gct ccc ctg gag tct cca cct ttt cct acc aag tcc cca gcg ttt      271
 Glu Ala Pro Leu Glu Ser Pro Pro Phe Pro Thr Lys Ser Pro Ala Phe
  20                  25                  30                  35

 gac ctt ttc aac ttg gtt ctc tcc tac aag agg ctg gag atc tac ctg      319
 Asp Leu Phe Asn Leu Val Leu Ser Tyr Lys Arg Leu Glu Ile Tyr Leu
                  40                  45                  50

 gaa ccc ttg aag gat gca ggt gat ggt gtt cga tac ttg ctc agg tgc      367
 Glu Pro Leu Lys Asp Ala Gly Asp Gly Val Arg Tyr Leu Leu Arg Cys
              55                  60                  65

 atg gta ctc agt agg tgc cct gat gat ttc agt gcc cgc cct gct ggg      415
 Met Val Leu Ser Arg Cys Pro Asp Asp Phe Ser Ala Arg Pro Ala Gly
          70                  75                  80

 cta cct tca gga ggt ttg ccg ggc acg gct gcc ctg att ccg aac tga      463
 Leu Pro Ser Gly Gly Leu Pro Gly Thr Ala Ala Leu Ile Pro Asn 
      85                  90                  95

 tgcggaggaa gtatcatagc gtgaggcagg aggacctgca gagagttcgc ctgtctcgtc    523

 ccaggccgtg gctgag                                                    539




      <210> 507
      <211> 1399
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (560)..(775)

      <400> 507
 cgccaagctt ggcacgaggc gtgtggaagg aggcggctcc ccgctgcctg ccctgaccta     60

 caggctaggt ggtggtctcc ttgttttggt gtcaaggact cagtaaaagc atctattttt    120

 ttagcactta agctggcaag gcggtagggg catgcactgt taggtggtgg ccacccccag    180

 ggtcagggga aaagaatggg tccatagagt gcccttgaag cagagaacag ccccgagcag    240

 tgtgaggaca gaggcatccc agcctcagcc ggtggggacg gctgccactc ccccagagcc    300

 ctgccacccc atgtgtccta ggctggtggc caaggccatg tgtgagggaa gaggggtacc    360

 tctcttccct gctgctggcc tggggtattt ccaaaacagc cttttcgcac acatgcaggt    420

 tgcaccgaga ggtctggagc tgtggctgag ccacctctgg cggatgttga gccaggaggt    480

 tgggcaaagg ccggatgctg atgccagcgc tggaggtggt gatactgggg gcggggaagg    540

 cctagaaata ctttgagcc atg gcc ttg cca gtg tcc cgt gcc ctc cag tgt     592
                      Met Ala Leu Pro Val Ser Arg Ala Leu Gln Cys
                        1               5                  10

 caa aga ttt ggg gca ctg ccc gtc gaa atg gaa agg ttg gtg ctc agc      640
 Gln Arg Phe Gly Ala Leu Pro Val Glu Met Glu Arg Leu Val Leu Ser
              15                  20                  25

 ctc tgg agc ctc acc tgc agg gcg tcc cca gct aac acc cat cca cgc      688
 Leu Trp Ser Leu Thr Cys Arg Ala Ser Pro Ala Asn Thr His Pro Arg
          30                  35                  40

 acc acc tcc agg acg aga acc ctt gat gtc aaa acc aag tgc cca gtg      736
 Thr Thr Ser Arg Thr Arg Thr Leu Asp Val Lys Thr Lys Cys Pro Val
      45                  50                  55

 gag gcg gtg aag ctc tcg gaa atg ctg cca cct gtg tga ggccgggtct       785
 Glu Ala Val Lys Leu Ser Glu Met Leu Pro Pro Val 
  60                  65                  70

 gaactcgagg gagtcggagc tcagctgtcg gtttaaagag acactgaggg gaccgggctg    845

 ccgccctcag cctgcattcc tgtgcgcaat cgattccgca atgacagcac cttactcctt    905

 cctgcggcag gctcacccct gcctgtggga tgttgtgaga ggaacatgag ccagacaaag    965

 acttggctca gggctccgtg gaacaagcca ggatgcacgg ggagctgggg gagcccccag   1025

 cctggggcag cccagcaggc cgctgaacaa acaccccaga agccagcact gtggcagggt   1085

 gctggggaga tgcccctctg agccttcctc ccccctcaga cctgaatgca ctccacagtt   1145

 gggggctgcc cctgccactc ccctggtaat gcataaaagg ggaggggaag gttccctggg   1205

 gcttgagctc cctctgtgga ggtgaggagg ggagattccg ttcacatcca ggaggggcaa   1265

 aatgactgat gtatttttat gtatctacac agagagtgca ttttctctcc agagatgctg   1325

 tctggttaac aaaggaataa cttaagaaat tgattgatta tcttaataaa ctgtgcaaac   1385

 ccaaaaaaaa aaaa                                                     1399




      <210> 508
      <211> 665
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (80)..(583)

      <400> 508
 acgatcctta ctcaaagcat ggttgctgag tacccagagt tgcgaggagt tttttaactg     60

 atttagccag gtggcaatc atg agt gaa tgg atg aag aaa ggc ccc tta gaa     112
                      Met Ser Glu Trp Met Lys Lys Gly Pro Leu Glu
                        1               5                  10

 tgg caa gat tac att tac aaa gag gtc cga gtg aca gcc agt gag aag      160
 Trp Gln Asp Tyr Ile Tyr Lys Glu Val Arg Val Thr Ala Ser Glu Lys
              15                  20                  25

 aat gag tat aaa gga tgg gtt tta act aca gac cca gtc tct gcc aat      208
 Asn Glu Tyr Lys Gly Trp Val Leu Thr Thr Asp Pro Val Ser Ala Asn
          30                  35                  40

 att gtc ctt gtg aac ttc ctt gaa gat ggc agc atg tct gtg acc gga      256
 Ile Val Leu Val Asn Phe Leu Glu Asp Gly Ser Met Ser Val Thr Gly
      45                  50                  55

 att atg gga cat gct gtg cag act gtt gaa act atg aat gaa ggg gac      304
 Ile Met Gly His Ala Val Gln Thr Val Glu Thr Met Asn Glu Gly Asp
  60                  65                  70                  75

 cat aga gtg agg gag aag ctg atg cat ttg ttc acg tct gga gac tgc      352
 His Arg Val Arg Glu Lys Leu Met His Leu Phe Thr Ser Gly Asp Cys
                  80                  85                  90

 aaa gca tac agc cca gag gat ctg gaa gag aga aag aac agc cta aag      400
 Lys Ala Tyr Ser Pro Glu Asp Leu Glu Glu Arg Lys Asn Ser Leu Lys
              95                 100                 105

 aaa tgg ctt gag aag aac cac atc ccc atc act gaa cag gga gac gct      448
 Lys Trp Leu Glu Lys Asn His Ile Pro Ile Thr Glu Gln Gly Asp Ala
         110                 115                 120

 cca agg act ctc tgt gtg gct ggg gtc ctg act ata gac cca cca tat      496
 Pro Arg Thr Leu Cys Val Ala Gly Val Leu Thr Ile Asp Pro Pro Tyr
     125                 130                 135

 ggt cca gaa aat tgc agc agc tct aat gag att att ctg tcg cgt gtt      544
 Gly Pro Glu Asn Cys Ser Ser Ser Asn Glu Ile Ile Leu Ser Arg Val
 140                 145                 150                 155

 cag gat ctt att gaa gga cat ctt aca gct tcc caa tga gaggccagga       593
 Gln Asp Leu Ile Glu Gly His Leu Thr Ala Ser Gln 
                 160                 165

 agtgtgaaca tactgataga aaaagactat attttatccc tcataaaatg ttttaaatgt    653

 aaaaaaaaaa aa                                                        665




      <210> 509
      <211> 1407
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (116)..(979)

      <400> 509
 ggttgtagcc ccgccccggg ccttgggctc cacctctcgg ccccacttcc gccgggcaag     60

 cgtttgtagg cggcgctgcc gtaaatcagg cggtctgctt gccgcatcac gcaag atg     118
                                                              Met
                                                                1

 gcg gcc gcg gcg gtg aac ggg gcg gca ggc ttc tcg agc tcc ggg ccc      166
 Ala Ala Ala Ala Val Asn Gly Ala Ala Gly Phe Ser Ser Ser Gly Pro
               5                  10                  15

 gcg gca acc tcg ggc gct gtt ctg cag gcc gcg acc ggc atg tac gag      214
 Ala Ala Thr Ser Gly Ala Val Leu Gln Ala Ala Thr Gly Met Tyr Glu
          20                  25                  30

 caa ctc aag ggc gag tgg aac cgt aaa agc ccc aat ctt agc aag tgc      262
 Gln Leu Lys Gly Glu Trp Asn Arg Lys Ser Pro Asn Leu Ser Lys Cys
      35                  40                  45

 ggg gaa gag ctg ggt cga ctc aag cta gtt ctt ctg gag ctc aac ttc      310
 Gly Glu Glu Leu Gly Arg Leu Lys Leu Val Leu Leu Glu Leu Asn Phe
  50                  55                  60                  65

 ttg cca acc aca ggg acc aag ctg acc aaa cag cag cta att ctg gcc      358
 Leu Pro Thr Thr Gly Thr Lys Leu Thr Lys Gln Gln Leu Ile Leu Ala
                  70                  75                  80

 cgt gac ata ctg gag atc ggg gcc caa tgg agc atc cta cgc aag gac      406
 Arg Asp Ile Leu Glu Ile Gly Ala Gln Trp Ser Ile Leu Arg Lys Asp
              85                  90                  95

 atc ccc tcc ttc gag cgc tac atg gcc cag ctc aaa tgc tac tac ttt      454
 Ile Pro Ser Phe Glu Arg Tyr Met Ala Gln Leu Lys Cys Tyr Tyr Phe
         100                 105                 110

 gat tac aag gag cag ctc ccc gag tca gcc tat atg cac cag ctc ttg      502
 Asp Tyr Lys Glu Gln Leu Pro Glu Ser Ala Tyr Met His Gln Leu Leu
     115                 120                 125

 ggc ctc aac ctc ctc ttc ctg ctg tcc cag aac cgg gtg gct gag ttc      550
 Gly Leu Asn Leu Leu Phe Leu Leu Ser Gln Asn Arg Val Ala Glu Phe
 130                 135                 140                 145

 cac acg gag ttg gag cgg ctg cct gcc aag gac ata cag acc aat gtc      598
 His Thr Glu Leu Glu Arg Leu Pro Ala Lys Asp Ile Gln Thr Asn Val
                 150                 155                 160

 tac atc aag cac cca gtg tcc ctg gag caa tac ctg atg gag ggc agc      646
 Tyr Ile Lys His Pro Val Ser Leu Glu Gln Tyr Leu Met Glu Gly Ser
             165                 170                 175

 tac aac aaa gtg ttc ctg gcc aag ggt aac atc ccc gcc gag agc tac      694
 Tyr Asn Lys Val Phe Leu Ala Lys Gly Asn Ile Pro Ala Glu Ser Tyr
         180                 185                 190

 acc ttc ttc att gac atc ctg ctc gac act atc agg gat gag atc gct      742
 Thr Phe Phe Ile Asp Ile Leu Leu Asp Thr Ile Arg Asp Glu Ile Ala
     195                 200                 205

 ggg tgc atc gag aag gcc tac gag aaa atc ctt ttc act gag gcc acc      790
 Gly Cys Ile Glu Lys Ala Tyr Glu Lys Ile Leu Phe Thr Glu Ala Thr
 210                 215                 220                 225

 cgg atc ctc ttc ttc aac aca ccc aaa aag atg aca gac tac gcc aag      838
 Arg Ile Leu Phe Phe Asn Thr Pro Lys Lys Met Thr Asp Tyr Ala Lys
                 230                 235                 240

 aag cga ggg tgg gtc ctg ggc ccc aac aac tac tac agt ttt gcc agc      886
 Lys Arg Gly Trp Val Leu Gly Pro Asn Asn Tyr Tyr Ser Phe Ala Ser
             245                 250                 255

 cag cag cag aag ccg gaa gac acc acc att ccc tcc aca gaa ctg gcc      934
 Gln Gln Gln Lys Pro Glu Asp Thr Thr Ile Pro Ser Thr Glu Leu Ala
         260                 265                 270

 aaa cag gtc atc gag tat gcc cgg cag ctg gag atg atc gtc tga gcc      982
 Lys Gln Val Ile Glu Tyr Ala Arg Gln Leu Glu Met Ile Val 
     275                 280                 285

 ccccgggcac tgggtggggc agggcacgag ttatttaaaa cagttacact gcagggtttc   1042

 gcccaataaa ggtggactga cattccctct tccaggccct tgtctcccca gttgggacgg   1102

 cagagagaca agttcttata tctgaagaac ttggaggttt tggggcattc aggagttgga   1162

 gatagcctcc aactgggtca gcctctgtct ggtgggcatt gctcagggtc tcaaacatgg   1222

 acgcccactg tggggcccca gcagcactgt ggcctgcagg agggcatggc cccaggtagg   1282

 gggactgttc tagccagctg tggacacata ggaatgctgg accagggtac cagatttttt   1342

 caacaaaggg ggtgaagtgt cctactaaaa agaataaatg ttggcagtga attaaaaaaa   1402

 aaaaa                                                               1407




      <210> 510
      <211> 1481
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (583)..(1026)

      <400> 510
 gatggacacg ccccctccct gtctcccacc gatgattggc gcacggaact ccgccttggg     60

 tttggaaggc tcgcctggga gctcatacct ggctagggcc gaggattggc tgttccgggg    120

 ctagggagcg ctttctcccg ggaaccgcgg ctgtgaccca agtggcccgg accagtttgg    180

 ggctgcgtgc ggcctgcctc aagcaaccag gtacgtaggt cggcggccca gctcggcgct    240

 gcggtgggag ccggagggcg acagtcagag ccggggtgcc agcgggacgc gaccgccaga    300

 tccacttagg accccgtcgt tctgcgaagc ggccacgtct gagtcccggg gcctcctcgt    360

 gctgcagatg tcgccttagg acctcggcca ggataccctc tgccatgctc ttgtgctgcc    420

 cgtgatcacc gactggccct tgtaagcacc ttcgcagcag gaagcccaga gctgcgcctg    480

 ccctttctga aggctgtgga agaggttgga gtgggcgcat cttagcttgc cccatcccca    540

 tttgaggtct gtcggagctg cccttcagtg tgagcatcca ca   atg ggt acc cca     594
                                                  Met Gly Thr Pro
                                                    1

 gcc tcg gtg gtc agt gag cca ccc cct tgg cag gcc ccg att gag gcc      642
 Ala Ser Val Val Ser Glu Pro Pro Pro Trp Gln Ala Pro Ile Glu Ala
   5                  10                  15                  20

 cgg ggc cgc aag cag gcc tcg gcc aac atc ttc cag gac gcc gag ctg      690
 Arg Gly Arg Lys Gln Ala Ser Ala Asn Ile Phe Gln Asp Ala Glu Leu
                  25                  30                  35

 ctg cag atc caa gcc ctg ttt caa cgc agc ggg gac cag ctg gcc gag      738
 Leu Gln Ile Gln Ala Leu Phe Gln Arg Ser Gly Asp Gln Leu Ala Glu
              40                  45                  50

 gaa cgg gca cag atc atc tgg gaa tgt gca ggg gac cac cgt gtg gct      786
 Glu Arg Ala Gln Ile Ile Trp Glu Cys Ala Gly Asp His Arg Val Ala
          55                  60                  65

 gag gcc ctc aag agg ctg cgc agg aag agg ccc cca agg cag aaa ccc      834
 Glu Ala Leu Lys Arg Leu Arg Arg Lys Arg Pro Pro Arg Gln Lys Pro
      70                  75                  80

 ctg ggc cac tcg cta cac cac tgc agc cgc ctc aga atc ctg gag ccc      882
 Leu Gly His Ser Leu His His Cys Ser Arg Leu Arg Ile Leu Glu Pro
  85                  90                  95                 100

 cac tct gca ctg gcc aac cca cag agt gcc aca gag aca gcc tcc agt      930
 His Ser Ala Leu Ala Asn Pro Gln Ser Ala Thr Glu Thr Ala Ser Ser
                 105                 110                 115

 gag cag tat ctg cac tct agg aag aaa agt gcc agg atc cgc cgg aac      978
 Glu Gln Tyr Leu His Ser Arg Lys Lys Ser Ala Arg Ile Arg Arg Asn
             120                 125                 130

 tgg agg aag tca ggc ccc aca agc tac ctc cac cag atc aga cac tga     1026
 Trp Arg Lys Ser Gly Pro Thr Ser Tyr Leu His Gln Ile Arg His 
         135                 140                 145

 tccagggaaa gagccaggaa tggcagtgtc ttccctcttg ccaaaaggcc tggggaggtg   1086

 aaggaagaga gactttaggc aagcagccca aaggggtaaa tgaaagcaag aggctgctgc   1146

 cactgacctg ctccattcag aacaagactg gatgcttctg ttgagctctc cattatgtgg   1206

 gacccattcc tcaccaaaat gaggagagac agtgactgtt cctgccacag tccttcccag   1266

 tctaacacta ttcctgggct gcatgatatt cccctgggag caaagtgaca ggcacttaga   1326

 tgcagcattt caccactcat gctactaatc atctacctgc tactactgta aaccatggtt   1386

 ccagcagcct gttccacacc cccacaccat caggatagca cagggaaact gtagtttaag   1446

 tggcaaataa aaacatttgc atcaaaaaaa aaaaa                              1481




      <210> 511
      <211> 1748
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (225)..(623)

      <400> 511
 gattcatgct tctcagactt taaaatgtgc cggcaaatct cctggcatcc ttgttaaaat     60

 gcaggtttga tctggtggtt ctttggggtg gggcccaaga ctacattttg tgatgagctc    120

 ctcgatgctg tgggtttttg ctggttcaag gagcacactt ggaatttcaa ggctcaggcc    180

 tgtaggcatt ctccccctct gtggcttggt gccctcgcca gacc atg gct gat gtc     236
                                                  Met Ala Asp Val
                                                    1

 aga gct ggt ttc cta gtg att gcc ccc tca ggg tct tcc tgc ttt tct      284
 Arg Ala Gly Phe Leu Val Ile Ala Pro Ser Gly Ser Ser Cys Phe Ser
   5                  10                  15                  20

 acc ctt acc ctg ccg gtg agg gac aac cta ctc atg cac cac ttg aag      332
 Thr Leu Thr Leu Pro Val Arg Asp Asn Leu Leu Met His His Leu Lys
                  25                  30                  35

 ttg agt tcc aga aag aag acg cca ggg atg agg ctg gga cag agg gtc      380
 Leu Ser Ser Arg Lys Lys Thr Pro Gly Met Arg Leu Gly Gln Arg Val
              40                  45                  50

 tca cgg atg gcc ccg ctg cca gga gca gaa ctg gtt cgg agg cca ctg      428
 Ser Arg Met Ala Pro Leu Pro Gly Ala Glu Leu Val Arg Arg Pro Leu
          55                  60                  65

 cag ctc tac cga tac ttg ctg cgc tgt tgc cag cag ctg ccg acc aag      476
 Gln Leu Tyr Arg Tyr Leu Leu Arg Cys Cys Gln Gln Leu Pro Thr Lys
      70                  75                  80

 ggc atc cag cag cat tac aag cat gct gtc agg cag agt ttt cgg gtt      524
 Gly Ile Gln Gln His Tyr Lys His Ala Val Arg Gln Ser Phe Arg Val
  85                  90                  95                 100

 cat tca gat gaa gac aac cct gag aga atc cag cag att att aaa aga      572
 His Ser Asp Glu Asp Asn Pro Glu Arg Ile Gln Gln Ile Ile Lys Arg
                 105                 110                 115

 gcc att gaa gat gct gac tgg atc atg aac aaa tat aaa aaa caa aac      620
 Ala Ile Glu Asp Ala Asp Trp Ile Met Asn Lys Tyr Lys Lys Gln Asn
             120                 125                 130

 tga gagc tccgagggtg agccttcctg gcctctggaa gttgagaggc ccctcttctg      677
 


 gagctcagca gcagcagctg gtttggaaga tccattggcc ttgttggctg aaagccagaa    737

 atcaggggag aagctgacct tgctccagag gctcctcttg ccgcggccat gttgctagca    797

 tcctttatgt ttgcacttcc agccacttac gatgtgaaat ttggggagaa tgtagtattt    857

 ttttgcttct tttgtgtgtt ttttattttt gtgtttttgt tcttttactt ttctctgaaa    917

 gtgattcatt tattctggag atctctttat cattctctga gtcccagagc agatgtcccc    977

 tcaggtagca acctgtacag aagaaagcac gtgggtttta gaaccagaca gatctggatt   1037

 tgaatcccag atgcaataag atgaaggtga agtgcctcac acaggatgtg gcacatgaca   1097

 gtgcctgaag ggctcccttc aaggaagccg tcctgccccg ccccctcctc tgctcctgca   1157

 gcgccctgca cagctctgct ccccgcatgc accgcatcgg gtctcagttt tttgtttgcg   1217

 agcttgccct gtccctgctt gtagcccctg agccctcaca gttgtcacac acccagcagt   1277

 ctgccaagga gctgcttttc ctgactactg tctctccatg cctagggaag tcaaagccct   1337

 gggccttgcc ttcagggagt tgacagtgtc cttgaagtgg tgaagtgccc accacatgaa   1397

 ccaaggagag acgccaaagc agctgccatg gactctggcc tgtccaagcc tctgtgcacc   1457

 tgcagtctct ttccactggc acttccctgc tttgctacca tcgtggaaga atggaaggga   1517

 gggggagaag gtgggtgggc tcagggagaa cggccagagt ggccagaaga tgcagagaga   1577

 agccccactg ggatctgagt attccccaag ggcactcagc cacagggatg aactagtgtt   1637

 tgtttgtatc cttgcagtta tgtgacttaa agtgactcag agatatctat gtatgcgagt   1697

 gtactccgct ggcaatgaag taaatatatc aatttgtgga aaaaaaaaaa a            1748




      <210> 512
      <211> 950
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (420)..(737)

      <400> 512
 tttcgtccgg cctcagctgg tttttcaaaa gtcatggcgt gtaattgtca gaacagtgaa     60

 cttcggtgat ccaccggagg ggcgaggcca cagctcgacc gcgagcacct gagcatcctg    120

 caccgcctgc gacggccgtc agggggcgcg atgccgcctc acagaacctc aagcggcgcc    180

 cgggttccgg cacagacggc ctgcggctcc agggggcgga gccgagccgt ctcctcagga    240

 cctacgcagg aggcgccgtc atccctacag ggacacctga gagggcccag cctcctcctc    300

 ctcaggaccc actcgggaga cgccgctggc tctctaggaa cacctgggga ccgtggccag    360

 ggacgaccca gcctccttct cctcagctcc tcaggaacga ctggggaagc tgtggcttc     419                                                                 
 atg gtc ccc gag gct gcc cga gga aag gta ttt cag gac agc cag gag      467
 Met Val Pro Glu Ala Ala Arg Gly Lys Val Phe Gln Asp Ser Gln Glu
   1               5                  10                  15

 ggg gcg cac atc cgc cgc gaa act gtg agc aag agc gtc tgt gct gaa      515
 Gly Ala His Ile Arg Arg Glu Thr Val Ser Lys Ser Val Cys Ala Glu
              20                  25                  30

 cca tgg cgc cac cag agg gcg cgc gat ccc gcc cca acc aac ttc ccg      563
 Pro Trp Arg His Gln Arg Ala Arg Asp Pro Ala Pro Thr Asn Phe Pro
          35                  40                  45

 ctg aag tgc cag aag cag cga gga gct tca act tcc tca ggg cag cac      611
 Leu Lys Cys Gln Lys Gln Arg Gly Ala Ser Thr Ser Ser Gly Gln His
      50                  55                  60

 ggg ggt cgt gtt aat ttg gtg ttc ttc att gat gat gat tat tcc cca      659
 Gly Gly Arg Val Asn Leu Val Phe Phe Ile Asp Asp Asp Tyr Ser Pro
  65                  70                  75                  80

 cct tct aag aga caa aga cca acg agc cac cac agc cac cag tcc cag      707
 Pro Ser Lys Arg Gln Arg Pro Thr Ser His His Ser His Gln Ser Gln
                  85                  90                  95

 aac ctg cca atg ctg ggg aac gga aaa tga g ggagttcaac tctggccctc      758
 Asn Leu Pro Met Leu Gly Asn Gly Lys 
             100                 105

 acaatccagt ggaggagacg aaactcatct gcctctgtcc ctctgggcac gcctcatgcc    818

 aggtgcatct gtggacaggg gccatgctcc tgggcttcca aagttggaga aagctgccag    878

 gctcaggtct gaaggccaga attctacagt aagtcctact gagtcaaggt gggagcaggg    938

 tcggtagctt cc                                                        950




      <210> 513
      <211> 1057
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (7)..(336)

      <400> 513
 gaaaag   atg gag ggg aag aaa tta caa cta ggg att gag gaa gat cta      48
          Met Glu Gly Lys Lys Leu Gln Leu Gly Ile Glu Glu Asp Leu
            1               5                  10

 gca gaa cct tct aag tct cag aca cgt aaa ccc aag tgt ggc aaa gga       96
 Ala Glu Pro Ser Lys Ser Gln Thr Arg Lys Pro Lys Cys Gly Lys Gly
  15                  20                  25                  30

 act cat tgc tct cga aat gca tat atg ttg gtt tat aga ctg caa act      144
 Thr His Cys Ser Arg Asn Ala Tyr Met Leu Val Tyr Arg Leu Gln Thr
                  35                  40                  45

 caa gaa aag ccc aac act act gtt caa gtt cca gcc ttt ctt caa gag      192
 Gln Glu Lys Pro Asn Thr Thr Val Gln Val Pro Ala Phe Leu Gln Glu
              50                  55                  60

 ctg gta gat cgg gat aat tcc aaa ttt gag gag tgg tgt att gaa atg      240
 Leu Val Asp Arg Asp Asn Ser Lys Phe Glu Glu Trp Cys Ile Glu Met
          65                  70                  75

 gct gag atg cgt aag caa agt gtg gat aaa gga aaa gca aaa cac gaa      288
 Ala Glu Met Arg Lys Gln Ser Val Asp Lys Gly Lys Ala Lys His Glu
      80                  85                  90

 gag gtt aag gag ctg tac caa agg tta cct gct gga gct ggt ctg taa      336
 Glu Val Lys Glu Leu Tyr Gln Arg Leu Pro Ala Gly Ala Gly Leu 
  95                 100                 105

 gatattctgg gacagcactg ttgccattaa gtgccttgtt tttttatgtt cacaaatgta    396

 tatgaagaaa ctttctcaaa cttactcttt ctaataaccc actaaagcca gcttaaacac    456

 tctaaaagta ctttgtaaac caacaataac ttgatgtgta gcattccata ttatttcatt    516

 acgttgtact cctaaaaatg ggaagctgtt aataaattat aacatttagg tcagcactct    576

 gcatccatga gtattgtaga tatttatatt ttgtgagata ttaacttgtt taagaaaaat    636

 ccgattggat tactatggaa aaagcaactt gcctgttctg tttctttgca tactttgtga    696

 cctaacagtt ttaacagaca ttctattata tgaatacagt ttttttgata ctattagatt    756

 aacttgaagt ttaataccaa atattatgct aagagtagaa aagctttctg ctgacccctg    816

 atttcttaga aatatcccac ataatccagc ttatcccttt tctgtatatg tttattcagg    876

 tttacctgat gtctcaaaat gaaaccaaat taagcctttt taaaggctga tgtgccattt    936

 gtattaagtt atctttgtca ttttaaagac atgaattccc caagcctaat tcctacttaa    996

 ggaagagaga caatttagtc cttactttag aaaataaata cttaagcata aaaaaaaaaa   1056

 a                                                                   1057




      <210> 514
      <211> 1592
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (760)..(1290)

      <400> 514
 cttccagtcg ctcgagagcg gagagcggca ccatggcccc gcgggggcgg cggcggccgc     60

 ggcctcacag gtctgagggc gcaagacgtt caaagaacac tttagaaaga acacattcca    120

 tgaaagataa agctggtcaa aagtgcaagc ctattgacgt gttcgacttt cctgataatt    180

 ctgatgtctc aagcattggc aggctgggtg aaaatgagaa agatgaagaa acttatgaga    240

 cctttgatcc tcctttacat agcacagcta tatatgctga tgaagaagaa ttctccaaac    300

 attgtggact gtctctctct tcaactcctc caggaaaaga agcaaaaaga agttcagaca    360

 cttctggaaa tgaagcaagt gaaatcgaat ctgtaaaaat tagtgcaaaa aagccaggaa    420

 gaaagctcag gcccattagt gatgactctg aaagcattga agaaagtgat acaaggagaa    480

 aagttaaatc agcagagaaa ataagtacac aacgtcatga ggttattcga accacagcgt    540

 cttcagaact ttcagagaaa ccagctgagt ctgtcacttc taaaaagaca ggacccctta    600

 gtgcccagcc ctctgttgaa aaagagaact tggcaataga aagtcaatcg aaaactcaga    660

 aaaaaaggga agatatctca tgacaaaagg aagaaatcaa gaagtaaagc cataggctca    720

 gatacttctg acattgtgca catttggtgt ccagaagga   atg aaa acc agt gac     774
                                              Met Lys Thr Ser Asp
                                                1               5

 atc aag gag ttg aat att gtt ttg cct gaa ttt gag aaa acc cac cta      822
 Ile Lys Glu Leu Asn Ile Val Leu Pro Glu Phe Glu Lys Thr His Leu
                  10                  15                  20

 gag cat caa caa aga ata gaa tct aaa gtt tgt aag gca gcc atc gcc      870
 Glu His Gln Gln Arg Ile Glu Ser Lys Val Cys Lys Ala Ala Ile Ala
              25                  30                  35

 aca ttt tat gtt aat gtt aaa gaa caa ttc atc aaa atg ctt aaa gaa      918
 Thr Phe Tyr Val Asn Val Lys Glu Gln Phe Ile Lys Met Leu Lys Glu
          40                  45                  50

 agc cag atg ttg aca aat ctg aaa agg aag aat gct aag atg att tca      966
 Ser Gln Met Leu Thr Asn Leu Lys Arg Lys Asn Ala Lys Met Ile Ser
      55                  60                  65

 gat atc gaa aag aaa agg cag cgt atg att gaa gtc cag gat gaa ctg     1014
 Asp Ile Glu Lys Lys Arg Gln Arg Met Ile Glu Val Gln Asp Glu Leu
  70                  75                  80                  85

 ctt cgg tta gag cca cag ctg aaa caa cta caa aca aaa tat gat gaa     1062
 Leu Arg Leu Glu Pro Gln Leu Lys Gln Leu Gln Thr Lys Tyr Asp Glu
                  90                  95                 100

 ctt aaa gag aga aag tct tcc ctt agg aat gca gca tat ttc tta tct     1110
 Leu Lys Glu Arg Lys Ser Ser Leu Arg Asn Ala Ala Tyr Phe Leu Ser
             105                 110                 115

 aat tta aaa cag ctt tat caa gat tat tca gat gtt caa gct caa gaa     1158
 Asn Leu Lys Gln Leu Tyr Gln Asp Tyr Ser Asp Val Gln Ala Gln Glu
         120                 125                 130

 cca aac gta aag gaa acg tat gat tca tcc agc ctt cca gct ctg tta     1206
 Pro Asn Val Lys Glu Thr Tyr Asp Ser Ser Ser Leu Pro Ala Leu Leu
     135                 140                 145

 ttt aaa gca aga aca ctt ctg gga gcc gaa agc cat ctg cga aat atc     1254
 Phe Lys Ala Arg Thr Leu Leu Gly Ala Glu Ser His Leu Arg Asn Ile
 150                 155                 160                 165

 aac cat cag tta gag aag ctc ctt gac cag gga tga gaag agcagtctac     1304
 Asn His Gln Leu Glu Lys Leu Leu Asp Gln Gly 
                 170                 175

 taaaatgtgc ctataggaag actagtctca tgctgttacc ttctgaaact gtacctttat   1364

 aaatcaattg ttttgcaaag aagttatggc ctacttagaa tctaaaattt gttattcaaa   1424

 ttaaatggct gtgaacaatg ttaaatagca tcagtttgtc caatagtttt aaaggccata   1484

 atcatctttt ctggttaata tcttgagtaa ttttaaaatg ttgacacctt aatcggtccc   1544

 aggtatgagc tataataaac ttgtaaaatt aagttgaaaa aaaaaaaa                1592




      <210> 515
      <211> 1632
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (390)..(1076)

      <400> 515
 ctttcatact gcctcctccc ttgtttttct gtctcagaga gatagtctgt cctaaatatc     60

 ccatgtagcc caggccactg aattaaaacg gagcgtattc gttctctgcc ccaccccgca    120

 actcctgaaa gcggcgcatc tcaattactt gatccttata tgccccacgc gggactcata    180

 ctacgtttcc cgtgaacacg tgcagtccaa accccgcccc tgatatttat ctcagtggac    240

 ggtggccgga aaaggacaat ggtttccatg tcagcggata aacgctctcc cctcggctcc    300

 cggacgcgac ggaggtcgta gtagtagtga gtacgtgctg aggagcaaag gagtaaccaa    360

 gagatccagt gaccgacaga gcaagagcc  atg ccg cgc cgg ggc ctg gtg gct     413
                                  Met Pro Arg Arg Gly Leu Val Ala
                                    1               5

 ggg cca gac ttg gag tat ttt cag cgt cgc tat ttc acg ccg gcg gag      461
 Gly Pro Asp Leu Glu Tyr Phe Gln Arg Arg Tyr Phe Thr Pro Ala Glu
      10                  15                  20

 gtg gcc caa cat aac agg ccc gaa gac ctc tgg gta tct tac ctg gga      509
 Val Ala Gln His Asn Arg Pro Glu Asp Leu Trp Val Ser Tyr Leu Gly
  25                  30                  35                  40

 cgc gtg tac gac cta acg tca ttg gca cag gaa tac aag ggg aac ctg      557
 Arg Val Tyr Asp Leu Thr Ser Leu Ala Gln Glu Tyr Lys Gly Asn Leu
                  45                  50                  55

 ctg ctg aaa ccc atc gtg gaa gtt gca ggc cag gat atc agc cac tgg      605
 Leu Leu Lys Pro Ile Val Glu Val Ala Gly Gln Asp Ile Ser His Trp
              60                  65                  70

 ttt gat cca aag acc aga gac atc cgc aag cac ata gat ccg ctg acc      653
 Phe Asp Pro Lys Thr Arg Asp Ile Arg Lys His Ile Asp Pro Leu Thr
          75                  80                  85

 ggc tgc ctg agg tac tgc acc ccg cgg ggc cgc ttt gtg cac gtt ccg      701
 Gly Cys Leu Arg Tyr Cys Thr Pro Arg Gly Arg Phe Val His Val Pro
      90                  95                 100

 cct cag ctg ccc tgt tcg gac tgg gcc aac gat ttt ggg aag ccc tgg      749
 Pro Gln Leu Pro Cys Ser Asp Trp Ala Asn Asp Phe Gly Lys Pro Trp
 105                 110                 115                 120

 tgg cag ggg tcg tat tat gag gtg ggg cgg ctg tct gcc aag acc cgg      797
 Trp Gln Gly Ser Tyr Tyr Glu Val Gly Arg Leu Ser Ala Lys Thr Arg
                 125                 130                 135

 agc atc cgc atc att aac acg ctc acg tcg cag gag cac aca ctg gag      845
 Ser Ile Arg Ile Ile Asn Thr Leu Thr Ser Gln Glu His Thr Leu Glu
             140                 145                 150

 gtg ggg gtt ctg gag tcc ata tgg gaa atc cta cac cgc tat ctc ccc      893
 Val Gly Val Leu Glu Ser Ile Trp Glu Ile Leu His Arg Tyr Leu Pro
         155                 160                 165

 tat aac tca cat gct gcc agc tac acg tgg aaa tat gaa ggg aag aac      941
 Tyr Asn Ser His Ala Ala Ser Tyr Thr Trp Lys Tyr Glu Gly Lys Asn
     170                 175                 180

 ctg aac atg gat ttt acc ctg gaa gag aat ggg atc cgg gat gag gag      989
 Leu Asn Met Asp Phe Thr Leu Glu Glu Asn Gly Ile Arg Asp Glu Glu
 185                 190                 195                 200

 gaa gaa ttt gac tat ctc agt atg gac ggt aca ctt cac aca cct gca     1037
 Glu Glu Phe Asp Tyr Leu Ser Met Asp Gly Thr Leu His Thr Pro Ala
                 205                 210                 215

 ata ctt ctg tac ttc aat gat gat ctc acg gag ttg tag gcaaggagat      1086
 Ile Leu Leu Tyr Phe Asn Asp Asp Leu Thr Glu Leu 
             220                 225

 gtacactcgt gtagactcaa gacgtatttc gagtttggct ttttctgtgc cttgaggaaa   1146

 agtggtgggg ccgaggggtg cctggaccca gatctccact cctctccagg agctagcctg   1206

 tgcccttctg aagtgtaaag gccctattcc ctgccttcat tacagtttgc tctgagaaaa   1266

 ttagtgaatt aatctttggg aatgatacaa gaagatcaag taccttggtt tagggagatg   1326

 tagaagagga tagtcagagt tcaggcagaa ctgtttgata gttaagagag agtagttcta   1386

 caggggtgag ggatggaagg acttttttgg caatgatgga aatgagatgt ctgcaggaag   1446

 atgggattta caaagaaata ggaaatgttt atcattgacc atacaaagct ggcttatctt   1506

 acttgtagaa gagtgttggc agctgaaacc caagggaaag aaaggaagtg cttcattata   1566

 ggcaattcag gctagatatt atactaggta cttcatatac cctctttttt tttttggccc   1626

 ccaaca                                                              1632




      <210> 516
      <211> 2818
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1308)..(2033)

      <400> 516
 gccagcctgt cctgcatctg ctcaagctct gagtgttgct gggaccgtgc atccacttcc     60

 tgaacctgtc tgtgcacagc cctgcgtcta ccccagagta gcccgcctcc ctgcccgagg    120

 ccccaggcgt gttttgcagc aggatgagat ctgtttgagg ccaccctgcc cttcttctgc    180

 agggctgggg caaaagggct ccgcaggccg tctcagccac cccatttcta gggcggcctg    240

 cttgtggcgc actagcagcc tttctatgct gaaggtggtg ggggtctttt cagtgttttt    300

 ctattttctt tcctacgaaa cagagcccct ccagggcagg cccaggcccc tcccagcctg    360

 tccgggccac agatacctgc agctgtggcc agtttccagg aggtctttga gcacacctgc    420

 ttcagcagcc ctgagcacac ctgcatcttc agtctcagtt tgaggggctg gaatggggag    480

 ggaagatgat ttggaaggat ttggggagag aagagatata caagccgggg ctgtctgggt    540

 ttggcccagg tgtgtgcccc tcttcaccac tccactttgt agattccctg tggcagggga    600

 tgcggttgca ggccccacgg aagtgcggag ggtggaggtg acgctggctc tgagttggga    660

 aacaggcacg tttgtgggtt cagagtcctg ggagagtctc gccaaggaaa caggaccagg    720

 cctggggctc agagaggcaa gaggaggggc agcctgggca gaggtgggct gggaaggggg    780

 cagggaagag gctgcgggca gctgggggtg gccctgtgct ggttggaagc tagcggtgag    840

 cgtcagatgg gggctgaagc ttgtcttaga gaggggcagg agcactggtc ctttgtttcc    900

 agcttctgaa gaggtaagaa ctccccagga gcaggggcag ggggaggggg aggaccatcc    960

 aaggaaacac tgcctcagct ggcagggcag aggtacagag tcaggaccag aggcttggca   1020

 atagggagac ggtagggaag ctggtgccac tggcagaaca ggagcaagta gggggtatac   1080

 ttttaagaga tgcctgatta aacctgggtt tgagttcttt ttctgtccct taccagctag   1140

 cgtagtcttg gttacttaag cactccgggc ctcagttttg tcatctatga aatgggaaca   1200

 gtagtgcaga ccttgacaca caggagcttc tcaaacagaa ggaatgagag gtgcagagca   1260

 gcagcaccag gagctccgct tcggggtgtg aatggccatg ggcggac  atg cag gtg    1316
                                                      Met Gln Val
                                                        1

 cag gac agg cga agt gtg gga cag atg aag ttt cta gcc tgg act gtg     1364
 Gln Asp Arg Arg Ser Val Gly Gln Met Lys Phe Leu Ala Trp Thr Val
       5                  10                  15

 agg ggc ctg gca gcc tcc cct ctc agg agc ccc tct acc tgc cct ggt     1412
 Arg Gly Leu Ala Ala Ser Pro Leu Arg Ser Pro Ser Thr Cys Pro Gly
  20                  25                  30                  35

 cct tcc agc tgg ccc gta ggc aag ctg ggg cat gca ggg aag gcc ctc     1460
 Pro Ser Ser Trp Pro Val Gly Lys Leu Gly His Ala Gly Lys Ala Leu
                  40                  45                  50

 tgt ggg gcc cga gga ttt gct gga gag cac tgt ggg tac aca agg ttg     1508
 Cys Gly Ala Arg Gly Phe Ala Gly Glu His Cys Gly Tyr Thr Arg Leu
              55                  60                  65

 gtg ggg gta cag ggc gtg cca ggg cac ctg caa gga gtt gag gag cgt     1556
 Val Gly Val Gln Gly Val Pro Gly His Leu Gln Gly Val Glu Glu Arg
          70                  75                  80

 gcc tta gga ggg aaa tca gta ttt ggg ctg act gag ggg agg agc tgg     1604
 Ala Leu Gly Gly Lys Ser Val Phe Gly Leu Thr Glu Gly Arg Ser Trp
      85                  90                  95

 aga gca gaa ggt tcc agg ccc agc aaa agc tgc tgg gat caa ggt gac     1652
 Arg Ala Glu Gly Ser Arg Pro Ser Lys Ser Cys Trp Asp Gln Gly Asp
 100                 105                 110                 115

 aga atg aga acc agg tgg gaa cag gta gta ccc agc ccc cat aaa caa     1700
 Arg Met Arg Thr Arg Trp Glu Gln Val Val Pro Ser Pro His Lys Gln
                 120                 125                 130

 ttc ctg ctg ggt cct cgg gcc tcc ctt gga ata cag ggg gtg ggc tgg     1748
 Phe Leu Leu Gly Pro Arg Ala Ser Leu Gly Ile Gln Gly Val Gly Trp
             135                 140                 145

 ttc tgc cac gca ttg cag ctg gag gag act tct cag gtg aga cga gga     1796
 Phe Cys His Ala Leu Gln Leu Glu Glu Thr Ser Gln Val Arg Arg Gly
         150                 155                 160

 cct ttg ctg cac tct cac aga cat gtg aca ggc ctt tct gtg ttg cct     1844
 Pro Leu Leu His Ser His Arg His Val Thr Gly Leu Ser Val Leu Pro
     165                 170                 175

 tcc cag gat gac ccc tcc ggc gaa ggt gtc ctg ccc tcg gcc cgc ggc     1892
 Ser Gln Asp Asp Pro Ser Gly Glu Gly Val Leu Pro Ser Ala Arg Gly
 180                 185                 190                 195

 cca gcc acc ttc ctc ccc ttc ctc act gtg gac ctg ccc gtc tac gtc     1940
 Pro Ala Thr Phe Leu Pro Phe Leu Thr Val Asp Leu Pro Val Tyr Val
                 200                 205                 210

 ctc cag gag gtg ctc ccc tca tct gga ggc cct gct gga ccg gag gcc     1988
 Leu Gln Glu Val Leu Pro Ser Ser Gly Gly Pro Ala Gly Pro Glu Ala
             215                 220                 225

 acc cag ttc cca gga agc act atc aac ctg cag gat ctg cag tga cgg     2036
 Thr Gln Phe Pro Gly Ser Thr Ile Asn Leu Gln Asp Leu Gln 
         230                 235                 240

 cagcctcggc ctgggcaggc ccaaggccac ggtctaggac acaccttccc tgagactcat   2096

 gacatgagcc tggggagacc tcatttggtt tccgttcaga agaccagcgt agcccttttg   2156

 agacttttgg gtacatttat caaaaatgtt ttccttttgt tttaccagga atgagttcgg   2216

 gctatactct ttgaaactgc ctttgtgagc aaagtgcttt ggcaaggcaa gggtctccct   2276

 cagcagggct aggtgcacta cagcctcttt ccccgtgtcc cgttggatct gagctgtgta   2336

 gcacttgttg cattacaaag aaaaagactt ctgcaggaaa tagggtagag aacaggctgt   2396

 ctagtcagat gcagcttgat ctgtggcaaa accaagtgtg gtctttcagc ttcagtgtgt   2456

 tagcatccca gcacctggga tggggtttgt gggcaagttg attttgccac actgtagggc   2516

 ccaggtggtc ccattgccac cgtgaagcca aattctagcc caagtctggt agagcagtcg   2576

 ggcagctagt tttcggggga ggatgatgtg gtgggacaga ggacctcagt ggcctattac   2636

 ggagccctct tcccagacta aattcatagc cgagagctcg gggggatggt agagttaaaa   2696

 tttaaaataa ttttctaaat tctgtatttg gatattagtg tttaagtggt aatttggcaa   2756

 cagtttataa agtgatgttc tgaataccat aaattatgtg taggactgtg aaaaaaaaaa   2816

 aa                                                                  2818




      <210> 517
      <211> 957
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (221)..(622)

      <400> 517
 ggaattagcg ggtcgacgat tccgttttac ccaaagccag gagtcctctt gtgatcaaaa     60

 tgctgattgg tttattgctt ctgatgtagc tcctcaagag aaatcattac cagaatttcc    120

 agactctggt tttcattcct ctctaacaga acaagttcat tcattgcagc attctttgga    180

 ttttgagaaa agttccacag aaggcagtga aagctccata  atg ggg aat tcc att     235
                                              Met Gly Asn Ser Ile
                                                1               5

 gac aca gtc aga tat ggc aaa gaa tca gat tta ggg gat gtt agt gaa      283
 Asp Thr Val Arg Tyr Gly Lys Glu Ser Asp Leu Gly Asp Val Ser Glu
                  10                  15                  20

 gaa cat ggt gaa tgg aat aag gaa agc tca aat aac gag cag gac aat      331
 Glu His Gly Glu Trp Asn Lys Glu Ser Ser Asn Asn Glu Gln Asp Asn
              25                  30                  35

 agt ctg ctt gaa cag tat tta act tca gtt caa cag ctg gaa gat gct      379
 Ser Leu Leu Glu Gln Tyr Leu Thr Ser Val Gln Gln Leu Glu Asp Ala
          40                  45                  50

 gat gag agg acc aat ttt gat aca gag aca aga gat agc aaa ctt cac      427
 Asp Glu Arg Thr Asn Phe Asp Thr Glu Thr Arg Asp Ser Lys Leu His
      55                  60                  65

 att gct tgt ttc cca gta cag tta gat aca ttg tct gac ggt gct tct      475
 Ile Ala Cys Phe Pro Val Gln Leu Asp Thr Leu Ser Asp Gly Ala Ser
  70                  75                  80                  85

 gta gat gag agt cat ggc ata tct cct cct ttg caa ggt gaa att agc      523
 Val Asp Glu Ser His Gly Ile Ser Pro Pro Leu Gln Gly Glu Ile Ser
                  90                  95                 100

 cag aca caa gag aat tct aaa tta aat gca gaa gtt caa ggg cag cag      571
 Gln Thr Gln Glu Asn Ser Lys Leu Asn Ala Glu Val Gln Gly Gln Gln
             105                 110                 115

 cca gaa tgt gat tct aca ttt cag cta ttg cat gtt ggt gtt act gtg      619
 Pro Glu Cys Asp Ser Thr Phe Gln Leu Leu His Val Gly Val Thr Val
         120                 125                 130

 tag catg tcttttggga ggcagatatc cacttaactt ttcttaaaaa tactttcagt      676
 


 tgcctttgct tttttttgga gggaaatact ccctacccct aattttgtta ctacttatat    736

 agaatttgta ttcatgtctt atatttttca gattctagat attgagctga gttttcattt    796

 tgattttgtt agctttttac ttagctgtaa ggtaccaaac tatttatatt gaaagctata    856

 tgcactttat ttcttaactg aattgcatca acaatgttcc tgtttctttc atgtactcat    916

 ttactttcaa aaataagcta gaatatatta aaaaaaaaaa a                        957




      <210> 518
      <211> 1272
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (426)..(785)

      <400> 518
 tttcgtgttc ttagtctgga agcccacatt tgctgcttaa gcttcttcga ttagaaaagg     60

 gagggggaaa acagtccaaa caggtcggaa aacgctcgtc ctagagccag gtgtcatgga    120

 catgaatgtt agaggactcc gcacaccttg gctgtctgtc tgtgcaatga caaccccccg    180

 tggcccttct gtaactacac cccagaccga gcccacaccc ccaaacccca gacctctttg    240

 atccgaagca gcttccgggg caaatgcggg cgcaggctcc cccatgcatg gactaatcag    300

 atgactctcg tttcttctct tctctctgtc tcctgtcctg cgtgtgtggc ctgcactgtc    360

 cctgggtgtc tttctgcctc atcctgccct ccgcatgacc caggacgggg ctcttcaccc    420

 ccgac    atg gcc ttt gaa gcc att gtg aaa aaa cag att gta aaa ctc     467
          Met Ala Phe Glu Ala Ile Val Lys Lys Gln Ile Val Lys Leu
            1               5                  10

 aaa gag ccg agt ttg aag tgt gtt gat ctc gtg gtc tca gag ctg gcc      515
 Lys Glu Pro Ser Leu Lys Cys Val Asp Leu Val Val Ser Glu Leu Ala
  15                  20                  25                  30

 acg gtc ata aaa aag tgt gcc gag aag gta aca ggt ttt gtt ctc atc      563
 Thr Val Ile Lys Lys Cys Ala Glu Lys Val Thr Gly Phe Val Leu Ile
                  35                  40                  45

 tcc gca ttt gtc ccc gtc ctc ccc ctc cat gtg tta gtc tca acc cga      611
 Ser Ala Phe Val Pro Val Leu Pro Leu His Val Leu Val Ser Thr Arg
              50                  55                  60

 gca tct gga aaa ttc agc ctc ggc agg aac ccc ctt ccg cct acc agt      659
 Ala Ser Gly Lys Phe Ser Leu Gly Arg Asn Pro Leu Pro Pro Thr Ser
          65                  70                  75

 tgt cac tta gag atg tcg cca cct tgc att ggc aga tgg aat ggg ggg      707
 Cys His Leu Glu Met Ser Pro Pro Cys Ile Gly Arg Trp Asn Gly Gly
      80                  85                  90

 agt ggc atc aca cgt ggg ttg tgg ctg ccc gtg ggg gcg gtc agc ctt      755
 Ser Gly Ile Thr Arg Gly Leu Trp Leu Pro Val Gly Ala Val Ser Leu
  95                 100                 105                 110

 tgt tgt tgc caa acg cat tgc att tac taa g cagtgccctt tcctggaacc      806
 Cys Cys Cys Gln Thr His Cys Ile Tyr 
                 115

 cctagagaaa ggggtttccc agccagcacc aaaacagcaa aacacaggaa acacatcatc    866

 tgtatagccc tgcatgttct cacagtctag gccacctgag agtaaccatt ccattttccc    926

 cgactcgtgg acttgaccca cactgcagaa gatgggactc ccctttgcat gaggtctggt    986

 taagttggtg ctgcagatga agcctgggga ggtgggggca tttggcgagt gtgtgccaca   1046

 gatacagtga tcaggagtgg ttctctgcaa ggagttccta tcgaggctga tggcccagat   1106

 acccgcctta ccattctaga acagacgcta ctcactcacg ctggcgaggc ccttcagggt   1166

 tcctgctctc acccagtgct gggcaagagg ggggtgccct gaagccctgc atggcaaaca   1226

 tgcccctgct tttctgcttt catgttgcct cctatctcct gcctcc                  1272




      <210> 519
      <211> 1491
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (400)..(702)

      <400> 519
 gcgtgtggag gggtggacga tgttatttga aaagttacag gacagatttt ctgtgttaat     60

 ggacatgagc catacattga gagggctgct ggctactgaa agaaatataa aattttaaaa    120

 tttctgaaat catgcagtta acatctgcac acttcactat attttaagtt tttgttaata    180

 taaaagaata agaaaacaga aaagtattac tgttaaacaa taatagagaa atgtatactt    240

 tatttacaaa tttctccctc tagctgatca tacagttgac cagttcaggg tgcccgctgc    300

 tggttggatg ccaggcggaa tgtcagggtg ttctctggtg tctgttgtgg ctgtgggatc    360

 cacggttact gggcggagcc ctgtggtggc tgtggtgcc   atg gag ggg ctg cga     414
                                              Met Glu Gly Leu Arg
                                                1               5

 tct tct gtg gag ctg gac cct gag ctg act cca ggg aag ctg gat gag      462
 Ser Ser Val Glu Leu Asp Pro Glu Leu Thr Pro Gly Lys Leu Asp Glu
                  10                  15                  20

 gag atg gtg ggg ctg cca ccc cat gac gcg agt cct caa gtc act ttc      510
 Glu Met Val Gly Leu Pro Pro His Asp Ala Ser Pro Gln Val Thr Phe
              25                  30                  35

 cac agc ctc gat ggg aag aca gtg gtg tgt cca cac ttc atg ggc tta      558
 His Ser Leu Asp Gly Lys Thr Val Val Cys Pro His Phe Met Gly Leu
          40                  45                  50

 ctg ctg ggt ctc tta ctt tta ttg act ttg tct gtt agg aac caa ctc      606
 Leu Leu Gly Leu Leu Leu Leu Leu Thr Leu Ser Val Arg Asn Gln Leu
      55                  60                  65

 tgt gta aga ggt gaa agg cag ctt gca gaa aca ctg cat tca cag gtg      654
 Cys Val Arg Gly Glu Arg Gln Leu Ala Glu Thr Leu His Ser Gln Val
  70                  75                  80                  85

 aag gag aaa tcc cag ctc att ggc aag aaa aca gat tgt aga gac tga      702
 Lys Glu Lys Ser Gln Leu Ile Gly Lys Lys Thr Asp Cys Arg Asp 
                  90                  95                 100

 ggcatcttta aaagatgtca gggtacagaa aaagtctttc aacacccccg gctttgtaga    762

 tgcctacaag aaggtgaata gcaccaacga gatgctgatg gagaaattta ccaccctcgt    822

 tcaagaactg aaagaagaga catcctccag actctccagg caacaagagg agctggtaga    882

 gatgctaaca acgctggagg ccctgggaga ggccatgaga gccaccccgt cacaaggagc    942

 ttttccacac ctgccatgca gctgagagcc aagccctgct gctctctccc ccacgagggg   1002

 gctgggtctt agagcagcac tgttcttttc ccctccaccc aggcctcccg agctgccagg   1062

 ctctgtgctc ccacactgac tccatctgag gggtccttga ggccagtgga tctggagtac   1122

 cccgcccctg gcctggagtt cctcctcctt ctcacgctga cactgcagcc agctcctcaa   1182

 tgggcggtgc ctccaaatct aaagaatatg gaggtcctgg agcacaccaa gaaatgaggg   1242

 actttttctt tgcagaaagt ttgaattctg tcttaatgag acagaatgcc atacttgagc   1302

 acctcatctt ttgctcaaat tgaaatgtca tcgaactgta tttctcaagt caatggtctg   1362

 taaatatgat ttatgtatta atctcctaag tgaacaattt atattttatc ctctacataa   1422

 ttatcgtatt atgctttaaa tatatattta gtttatcaat aaagacattc agtactcaaa   1482

 aaaaaaaaa                                                           1491




      <210> 520
      <211> 1018
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (351)..(566)

      <400> 520
 aatagaaaaa tgccaattaa gctctttttc agtcttggga ttgtttttgc cttcagttgg     60

 tagccctcaa tagaaaatag gtcttgtgtc agcagatgtt gacaacaaag aaagggaagc    120

 ttttaatttg ttcactaata gtgaaaaagc aaacatttac ataacacaaa tgtactgata    180

 aacacaatta aggatatatg cttgcctatt tgtgatccaa gtgttcaatt aaaattatat    240

 aattattgtg aaacagagga ggatgatgtt caagctatca ccgattggcc tgctcttcat    300

 gtttgttaac attccaggga caaacttcaa catcaacaac ctcaaattct   atg gca     356
                                                          Met Ala
                                                            1

 gta tcc aat cct gcg tca agc ctg aat ccc ggg acc aga cct aat ccc      404
 Val Ser Asn Pro Ala Ser Ser Leu Asn Pro Gly Thr Arg Pro Asn Pro
           5                  10                  15

 agg aag agc acc aat ccc aga atg aac ccc aat cct ggg ata agc cca      452
 Arg Lys Ser Thr Asn Pro Arg Met Asn Pro Asn Pro Gly Ile Ser Pro
      20                  25                  30

 gat ctc aaa atg acc tcg agt ccc aag atg act cca aat tcc aag aca      500
 Asp Leu Lys Met Thr Ser Ser Pro Lys Met Thr Pro Asn Ser Lys Thr
  35                  40                  45                  50

 agt ctg aat aga gca gtg acc cca aag agc cac aac tat gaa tat gaa      548
 Ser Leu Asn Arg Ala Val Thr Pro Lys Ser His Asn Tyr Glu Tyr Glu
                  55                  60                  65

 tac tgt gac aaa tgg tag caccaa tcctgggaca agcccaaatc tcaaaatgac      602
 Tyr Cys Asp Lys Trp 
              70

 ctcaaatccc tagatgactc caaattccaa gacaagtctg aatacagcag tgaccccaaa    662

 gatagccaca actatgaata tgaacactgt gacaaatggt agcaccatac tcaatccaat    722

 ggacaacatt tattttctat gtaatatttt tgctgttttg tgtatacttg cactcaggct    782

 gaagtgaact tcaactgcct gcattcttat ctcagtttct tattattgct gaatgacaag    842

 catgctagga aaatatcatt tatttcaatt tactatttaa gaaattatca tcttgatttt    902

 tttttgcaaa ttataattgt gtacgtttaa atattaactt aatatgatgt tttccttcca    962

 tatgaaagaa gtatgcacta ccttattaaa tgctgaaaca agcaaaaaaa aaaaaa       1018




      <210> 521
      <211> 1132
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (105)..(872)

      <400> 521
 ccaggggatc gagaacctat gtagacagcg atgatctggt aactggcaca cttcccaagc     60

 tcaagagctc aaaagaatgg ttggagccca agcccctttg tttt atg gag gtt tta     116
                                                  Met Glu Val Leu
                                                    1

 gct aaa gaa gat act gag gca gct att caa tca ata tta tac aaa gaa      164
 Ala Lys Glu Asp Thr Glu Ala Ala Ile Gln Ser Ile Leu Tyr Lys Glu
   5                  10                  15                  20

 aat tct gta att aag gaa cta gat aag tat tta caa cat cat gcc ttc      212
 Asn Ser Val Ile Lys Glu Leu Asp Lys Tyr Leu Gln His His Ala Phe
                  25                  30                  35

 tta aat gca aga aga aag gag atg tta tat aaa aga tgg gtt gac tgt      260
 Leu Asn Ala Arg Arg Lys Glu Met Leu Tyr Lys Arg Trp Val Asp Cys
              40                  45                  50

 gtg gca gat cct ctt cag aag aaa att ata gaa aaa gtt tgc tca cat      308
 Val Ala Asp Pro Leu Gln Lys Lys Ile Ile Glu Lys Val Cys Ser His
          55                  60                  65

 aag aag att aaa aaa agg agg caa ggg gaa tta gat ggc ttt tta aaa      356
 Lys Lys Ile Lys Lys Arg Arg Gln Gly Glu Leu Asp Gly Phe Leu Lys
      70                  75                  80

 cat gta aat aaa aag gga aat gca ttt ata gaa cat tat gat cca aaa      404
 His Val Asn Lys Lys Gly Asn Ala Phe Ile Glu His Tyr Asp Pro Lys
  85                  90                  95                 100

 gag tat gat ccc ttt tat atg agc aag aag gac ccc aat ttt ctg aag      452
 Glu Tyr Asp Pro Phe Tyr Met Ser Lys Lys Asp Pro Asn Phe Leu Lys
                 105                 110                 115

 gtt acc atc cca cca ttt cat gac cct ttg aaa aaa gca caa tat gac      500
 Val Thr Ile Pro Pro Phe His Asp Pro Leu Lys Lys Ala Gln Tyr Asp
             120                 125                 130

 aag gat aat gaa aaa aga act ctt ctt cag tgt gag act ggc aaa ata      548
 Lys Asp Asn Glu Lys Arg Thr Leu Leu Gln Cys Glu Thr Gly Lys Ile
         135                 140                 145

 tat tca ata aag gaa ttc aaa gaa gtt gag aag gtt cag ctg cat tcc      596
 Tyr Ser Ile Lys Glu Phe Lys Glu Val Glu Lys Val Gln Leu His Ser
     150                 155                 160

 aga ttc cca caa att tct aat tca agg cac ttt ata act cca aac gag      644
 Arg Phe Pro Gln Ile Ser Asn Ser Arg His Phe Ile Thr Pro Asn Glu
 165                 170                 175                 180

 tgg ctg aaa ctg cct aca aga tac ata gaa agt gaa ttt tgt aga agg      692
 Trp Leu Lys Leu Pro Thr Arg Tyr Ile Glu Ser Glu Phe Cys Arg Arg
                 185                 190                 195

 aga aga aac aaa ggg tca tcc ttt cta gaa aga gaa ccg ctg tgc tat      740
 Arg Arg Asn Lys Gly Ser Ser Phe Leu Glu Arg Glu Pro Leu Cys Tyr
             200                 205                 210

 cag gag gga aat aat cca agt gcc aaa gag gcc atc tct gaa ggg tat      788
 Gln Glu Gly Asn Asn Pro Ser Ala Lys Glu Ala Ile Ser Glu Gly Tyr
         215                 220                 225

 ttt tct tcc ttg agc ctc agc cag gaa cgg gag gaa gac cag gat ggg      836
 Phe Ser Ser Leu Ser Leu Ser Gln Glu Arg Glu Glu Asp Gln Asp Gly
     230                 235                 240

 ttt cag caa cca agg agc aca cac cct gat cct tga ttgg tgaaaggata      886
 Phe Gln Gln Pro Arg Ser Thr His Pro Asp Pro 
 245                 250                 255

 cacaaaatca ggctgcttca gaggaagtca tctgctcaca ggaatcaggg tgaaggccaa    946

 ggacggcact caagaattgt cctgtctcta aaaaaaaagc atctgcaacg aacttccttt   1006

 aatttttgag ttcagtgtct gtgataatta agaaatggca ataccatgta ttttccccag   1066

 aagttaagaa atattgctga acgaaccaat aaaaataatt acagctccct caaaaaaaaa   1126

 aaaaaa                                                              1132




      <210> 522
      <211> 652
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (65)..(292)

      <400> 522
 cggcacgagc tgtatgattt gaatgatttg aaaggggtgg ggccgagcaa ggtggagacc     60

 agcc atg tgc aga ctc aca tgg gcg gtc cag gcg gga gcc gtt gtt ggc     109
      Met Cys Arg Leu Thr Trp Ala Val Gln Ala Gly Ala Val Val Gly
        1               5                  10                  15

 cac agc agt gat aca gag atc atg gcc caa ggg gaa gcg tcc aca atg      157
 His Ser Ser Asp Thr Glu Ile Met Ala Gln Gly Glu Ala Ser Thr Met
                  20                  25                  30

 cag gat ggc tgg cca ggg gta gct gta gca ggc cat gat ggg ctc gca      205
 Gln Asp Gly Trp Pro Gly Val Ala Val Ala Gly His Asp Gly Leu Ala
              35                  40                  45

 gct ggc ctg cat ggc ctc gca cag gct gta gga ggg gta gat gac cct      253
 Ala Gly Leu His Gly Leu Ala Gln Ala Val Gly Gly Val Asp Asp Pro
          50                  55                  60

 ttg ggg gaa agg gtc ggg ggc tgc acc gcc aca ggc tga gcacccagat       302
 Leu Gly Glu Arg Val Gly Gly Cys Thr Ala Thr Gly 
      65                  70                  75

 cagctggaac ctctccatgt tcctacccct gtctcgtggc ctggaactct ctggttgctg    362

 ggcaacgaca ctggtcgcct agcaacagcc ccgtagcctg gctttcccac ttgccccaca    422

 tctcagccct cagctctgcc tcttcactcc cgccctccca ctcaggtgcc ttgccagctt    482

 tccagtgcac ctctccctcc ggctctgtgg acatccattg tctgcaagag gtggcctgca    542

 ccttgggcct ttactctcca tcttaaagtg aggaaacagg gccctccctc ttgtcctgaa    602

 aggccttcgg ggcaccgcag ccagggctgg ggttggcaaa cagttcaagg               652




      <210> 523
      <211> 772
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(535)

      <400> 523
 ctccagggca gaggcattga cctgttcaag gagcgcgtct  atg cag cga atc att      55
                                              Met Gln Arg Ile Ile
                                                1               5

 aag aac aac gaa gtc gtc gac gaa acc tgg cac ctg ctg ccc aag gac      103
 Lys Asn Asn Glu Val Val Asp Glu Thr Trp His Leu Leu Pro Lys Asp
                  10                  15                  20

 gcg agc ttc gat ggc atc tcc aac tgc gac gac ctg atc gtg ccg ctg      151
 Ala Ser Phe Asp Gly Ile Ser Asn Cys Asp Asp Leu Ile Val Pro Leu
              25                  30                  35

 gcc ctg tgg cgc gag cac gct cac gcc ctc aag gcc cgc gat ggc ggc      199
 Ala Leu Trp Arg Glu His Ala His Ala Leu Lys Ala Arg Asp Gly Gly
          40                  45                  50

 ctg ggt gtg tgg ctg gac gcc gat gaa gaa gcc gaa gag atc ggt gag      247
 Leu Gly Val Trp Leu Asp Ala Asp Glu Glu Ala Glu Glu Ile Gly Glu
      55                  60                  65

 gac gtg gag cac ttc cag gtc att gcc ctg aac ttc ccg gcc ttc acc      295
 Asp Val Glu His Phe Gln Val Ile Ala Leu Asn Phe Pro Ala Phe Thr
  70                  75                  80                  85

 gac ggt cgc aac tac tcc aac gcc cgc ctg ctg cgt gac cgt tat ggt      343
 Asp Gly Arg Asn Tyr Ser Asn Ala Arg Leu Leu Arg Asp Arg Tyr Gly
                  90                  95                 100

 tac aaa ggc gag ctg cgg gcg att ggc gat gtg ctg cgc gac cag ttg      391
 Tyr Lys Gly Glu Leu Arg Ala Ile Gly Asp Val Leu Arg Asp Gln Leu
             105                 110                 115

 ttc tac ctg cgc cgc tgc ggg ttc gat gcc ttc gcc ttg cgc gca gac      439
 Phe Tyr Leu Arg Arg Cys Gly Phe Asp Ala Phe Ala Leu Arg Ala Asp
         120                 125                 130

 aaa gac ccg tat gaa gcg ctg gaa agc ctc aag gat ttc tcg gtg acg      487
 Lys Asp Pro Tyr Glu Ala Leu Glu Ser Leu Lys Asp Phe Ser Val Thr
     135                 140                 145

 tac cag gcc gcg acg gat gaa ccg ttg cca ttg ttc cgc cgc cgt taa      535
 Tyr Gln Ala Ala Thr Asp Glu Pro Leu Pro Leu Phe Arg Arg Arg 
 150                 155                 160

 gcctcgcgcc aataaaaagc cccgacccgt cggggctttt tgcattcagg cggcgggctg    595

 caatgcgagt tgcaccgcac catcaacact caacccactg atcagcacct gcggtgcaca    655

 cgcctctggc aatgtctgca acacctcctg cgcctcatgg cgtacgcggg ccagcaccag    715

 gcacttgccc tccccttgca cttgtacgaa aaacgcctgc aatgcctctg ccctgga       772




      <210> 524
      <211> 1298
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (675)..(1091)

      <400> 524
 aaatggaaga ggcttttatt tgtaaagaaa tgaacttaca actgatctac aatatattat     60

 tgtaatataa acaatataaa taaatgatcc tgtaggccca ctaatcttcc atccagaccc    120

 acatgaagca atgttacaac aatattctat atgaaaatgt gcaggtaaca aaggtgcaat    180

 tacaagcaag ttaagcagca gagtataagg tgctttaatt taatagttaa tgttgccatc    240

 aacaaacatt taaatgctca atttacttca ctgaatacag acacaacaaa tatgaaaatc    300

 taaattcata cacatgctac ttaatatgaa agtgctttct cttttttaaa aaaatacacc    360

 aaatggacac tttttacata gatcaaatgt gctcttacaa tgcaaaatta accttcattt    420

 tcaggttata cattttaaaa ctgtagctat caacaccaat ctaggaactc taatgctaag    480

 agtgctaaaa actatttcat ttcttgtaag gaggactcta atacaatatc caatgtaaag    540

 aatacatcta tatataatct taacatgttt tctgtaaaga taaaaaatgt tttctttccc    600

 cttggtgatc tttgttcatc ctgggtggat catcttttga ggttttaata atatgaaagt    660

 cctattttag aaca  atg gga gga acc aaa agg gga att aaa aaa ttg gtt     710
                  Met Gly Gly Thr Lys Arg Gly Ile Lys Lys Leu Val
                    1               5                  10

 aac gtg tgc ttg aag cat cca aaa aac acc agt tta tca caa caa ttg      758
 Asn Val Cys Leu Lys His Pro Lys Asn Thr Ser Leu Ser Gln Gln Leu
          15                  20                  25

 gtc ttt gct aaa att aac aaa att tta ata agc aag acg aca aaa agt      806
 Val Phe Ala Lys Ile Asn Lys Ile Leu Ile Ser Lys Thr Thr Lys Ser
      30                  35                  40

 act aat tta aaa ggc ttg aaa tgc ctg cca cca ttg tca gta tcc atc      854
 Thr Asn Leu Lys Gly Leu Lys Cys Leu Pro Pro Leu Ser Val Ser Ile
  45                  50                  55                  60

 cat cca acc ttc att tac tac aag cac aat act act ttg agg ata gtt      902
 His Pro Thr Phe Ile Tyr Tyr Lys His Asn Thr Thr Leu Arg Ile Val
                  65                  70                  75

 ttt gga act tat ttt gac ttt ttt ccc tat agg aaa aac aaa gac caa      950
 Phe Gly Thr Tyr Phe Asp Phe Phe Pro Tyr Arg Lys Asn Lys Asp Gln
              80                  85                  90

 gct ttt gaa gga gag gac tgg gaa tct agt tta aat gtc tac atc caa      998
 Ala Phe Glu Gly Glu Asp Trp Glu Ser Ser Leu Asn Val Tyr Ile Gln
          95                 100                 105

 aat tat atc atc ttt gcg cat tca gtt gac ttt tta aaa ttt aag aat     1046
 Asn Tyr Ile Ile Phe Ala His Ser Val Asp Phe Leu Lys Phe Lys Asn
     110                 115                 120

 aca tat aca aaa agt act tat gga ata cat att tta aca gca taa cat     1094
 Thr Tyr Thr Lys Ser Thr Tyr Gly Ile His Ile Leu Thr Ala 
 125                 130                 135

 atttgaagaa ttagttacac tttaaaaatt aaaacacttg aaaagtattt tttaaaccag   1154

 taccatggaa taactttttg aaacccagat tatctggcta cttagatgat agtcttcctg   1214

 ttttcaatta gtttgaaaga ttctaatata gattctaacc caacagttta tatggatatt   1274

 ttcctgcttt aaaaagctgc aaca                                          1298




      <210> 525
      <211> 2702
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (917)..(1366)

      <400> 525
 tattccaaca gtcatgagta caaacaggcc gtccatgagc ttgtgcgttg cgtagcactg     60

 acaagaattt gctatggaga ctcacattgg aaactagcag aggcacatgt taatctggct    120

 caaggctacc tccagctgaa aggactgtca ctgcaagcaa aacaacatgc agaaaaagcc    180

 agacaaatcc tcgccaactc cattgtgcct ccctatagtg agaatacaga tgttttcaag    240

 ttttccattg agcttttcca taccatgggc agagctttac tctcccttca aaagtatcct    300

 tttgcctcta acttttacaa atagaaatac tattcacgta acacttacac gccaagtaaa    360

 aagctgatgc tgatggatga cttaggaagt gtgattggaa gtatgggagc caaggaagtt    420

 caggacatgg ggtgtagaat ctagaaccaa gtggaaaatt tcctgaacac aattcagatt    480

 taaggaagct gcagagaatt tgacaaaagc agagagactt tcaaaggagc tgctacaatg    540

 tggaagaatt ataaaggaag aatggataga aattgaagca cggatcagat tatcatttgc    600

 acaggtgtat caaggtcaga agaagtcaaa agaagctttg tcccactatc aagcagcttt    660

 ggaatatgtt gagatcagta aaggtgaaac aagtcgtgag tgtgtaccca tattgagaga    720

 attagcaggt gtagagcaag ccctgggact ccacgatgta tccatcaacc acttcctcca    780

 ggcacatctc atcatcctga gtagaagccc ctctcaagtg gaggcagcag actcggcaca    840

 catcgtcgcc catgctgctg tcgcttcagg gagacacgag caccatgatg tagctgagca    900

 gtattttcaa gagagc    atg gct cat ctt aag gat tct gaa ggg atg gga     949
                      Met Ala His Leu Lys Asp Ser Glu Gly Met Gly
                        1               5                  10

 aga acc aaa ttt ctt tca att caa gat gaa ttt tgc cat ttt cta caa      997
 Arg Thr Lys Phe Leu Ser Ile Gln Asp Glu Phe Cys His Phe Leu Gln
              15                  20                  25

 atg act gga caa aaa gag aga gca acc tcg atc ctg aga gag tcc ctg     1045
 Met Thr Gly Gln Lys Glu Arg Ala Thr Ser Ile Leu Arg Glu Ser Leu
          30                  35                  40

 gaa gcc aaa gtg gaa gca ttt ggc gat ttc agt ccc gag gtg gca gag     1093
 Glu Ala Lys Val Glu Ala Phe Gly Asp Phe Ser Pro Glu Val Ala Glu
      45                  50                  55

 aca tac cgg ctc ctg gga gga gca gac ctg gcg cag ggg aac cac agt     1141
 Thr Tyr Arg Leu Leu Gly Gly Ala Asp Leu Ala Gln Gly Asn His Ser
  60                  65                  70                  75

 ggg gcc cgc aag aaa ctg aag aag tgt ctc cag atc cag acc ctc tta     1189
 Gly Ala Arg Lys Lys Leu Lys Lys Cys Leu Gln Ile Gln Thr Leu Leu
                  80                  85                  90

 tat gga ccg cag gac aaa agg act ctg gcc acc cag cag gcc atg ggc     1237
 Tyr Gly Pro Gln Asp Lys Arg Thr Leu Ala Thr Gln Gln Ala Met Gly
              95                 100                 105

 atg ctg tcc acg gcc ccc aag gtt gct tcg aag cca agg cag gca tca     1285
 Met Leu Ser Thr Ala Pro Lys Val Ala Ser Lys Pro Arg Gln Ala Ser
         110                 115                 120

 aaa gcc aaa gtg gcc ttc tgc acc agc atc cct cag gac acc ctg ctg     1333
 Lys Ala Lys Val Ala Phe Cys Thr Ser Ile Pro Gln Asp Thr Leu Leu
     125                 130                 135

 ggg aag gcc cgg ccc ggc aca aca gca gac tga ggccccca ccctgaaaaa     1384
 Gly Lys Ala Arg Pro Gly Thr Thr Ala Asp 
 140                 145

 gcctaggaca ttcctgggca ctgtcattta gggtgctgta caaatcacct ccgcctagaa   1444

 aatggaattc aacagtcagg atacagattt ccaaggccaa ctgttggccc caacatgcaa   1504

 cagtgagacc ataagcctcc cgtgggccac attttgacag tggatgccct tcagggtgat   1564

 atatgctata aagcagtttt ctatcaccta agtggttttt cttgccaaca agaattttta   1624

 cccatcagca ctactgtggc tgaaaaactt ctcttcaaca gttcagtgcg ccctgtgcag   1684

 gagtcagccc ggcatctgct tgtacacaca gctccttgca taggtgtgga gttagatctg   1744

 gacagtgaac ttcaggaagt cctttcttat aggaggctaa tagggattga gaataacatg   1804

 agaagaaaac gctaataaag ggaaacctga acacgctgct gtcagcatgt gttttcaaag   1864

 tgcagcctgc ctcagagttc ttcggagcct gaaaaggggt ttgagaaaga gcccagtagg   1924

 aggggcagga ggccgacaca cctgacttgg cctggggccc aggaggcagg tgtaagggag   1984

 tgaaaagaaa ggctagccgg aggctgcggg gggaagaccg cagactccct gctgcttcgc   2044

 atccctcctg tggcctccac tgcaggcagg acaaacctgg atgccacctg gagctgcttc   2104

 ctgagttggc acactatcgt gtacacagca gtcttcagcc ccctggaagg aggccatagt   2164

 cgtgtgagga tggcaaagtc gaacaggaag ctttgagtgc cttcctccac gatgtcaacg   2224

 aggagatcca gtgccagatc gaggtggatg gaacacccag gggtaggggt gcaggtgtgg   2284

 gcagtgatgt cccttcccct ccctcccctg gtcccacaga ctgtggccat gaggctgcag   2344

 gctggtgcta tgacagcaga ttgcagcaca gggccctccc ctccagcccc cagtgggaca   2404

 tcaaaaccac cctggggcca tttgtgcagg gcaccacctc cagtattgat ggggaaaata   2464

 aactcagtag agccacgaca gggtggagag aagcagggac cattgtcttc ctcaggagcg   2524

 tgacagctga ccccacagac catgcttgct ggtacacact ggtcccagac ccaggcctgt   2584

 cggacatcag cagtgtgcta aaaacgtgta agatgtggtc actactcacc gtgtgtccta   2644

 tctagttgac atgggtggag tcagctaagg ggtgaatgtt catatgctcc caattcac     2702




      <210> 526
      <211> 506
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (408)..(488)

      <400> 526
 ggcaggtgac atttcctttg attagagaca agggacccag gttcttaggt aaagaaatgg     60

 ctattggagc tcggattctg gtgaggaaat gggagaggca ggcctcttat tctggtgagg    120

 aaatgggaga ggcaggactc tttggtagaa aagtgggaga ggcagaactc ttattctggt    180

 gagaggacct gtgagaatct tgactcttgc tccagtaagg gattggtcag cccagactgc    240

 gcctcccccc tatccctgtg cccacaggcc cgtggcagga ttgtgcagag gcccgccagg    300

 caggccatga acagagtgga gtgtatgaac tgcgagtggg ccgccacgta gtgtcagtat    360

 ggtgtgagca gcaactggag gggggtgcct ggcctgtgat ccagcgg  atg caa gat     416
                                                      Met Gln Asp
                                                        1

 ggt tca gtc aac ttg ttc act acc cgt gag cac tat aag gcg ccg cag      464
 Gly Ser Val Asn Leu Phe Thr Thr Arg Glu His Tyr Lys Ala Pro Gln
       5                  10                  15

 gtg ggc aga ggc agg aaa gag tag agagcctggc taggttcg                  506
 Val Gly Arg Gly Arg Lys Glu 
  20                  25



      <210> 527
      <211> 862
      <212> PRT
      <213> Homo sapiens


      <400> 527
 Met Leu Arg Asn Ser Thr Phe Lys Asn Met Gln Arg Arg His Thr Thr
   1               5                  10                  15    
 Leu Arg Glu Lys Gly Arg Arg Gln Ala Ile Arg Gly Pro Ala Tyr Met
              20                  25                  30        
 Phe Asn Glu Lys Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu
          35                  40                  45            
 Asp Ser Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu
      50                  55                  60                
 Glu Ser Lys Thr Leu Asn Phe Asn Cys Val Asp Tyr Met Gly Gln Asn
  65                  70                  75                  80
 Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu
                  85                  90                  95    
 Leu Leu Lys Lys Glu Asn Leu Ala Arg Val Gly Asp Ala Leu Leu Leu
             100                 105                 110        
 Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His
         115                 120                 125            
 Pro Ala Phe Ala Gln Gly Gln Arg Leu Thr Leu Ser Pro Leu Glu Gln
     130                 135                 140                
 Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg
 145                 150                 155                 160
 Phe Ser His Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu
                 165                 170                 175    
 Tyr Glu Ile Val His Ile Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg
             180                 185                 190        
 Pro His Asp Tyr Phe Cys Lys Cys Asn Glu Cys Thr Glu Lys Gln Arg
         195                 200                 205            
 Lys Asp Ser Phe Ser His Ser Arg Ser Arg Met Asn Ala Tyr Lys Gly
     210                 215                 220                
 Leu Ala Ser Ala Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu
 225                 230                 235                 240
 Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Arg Leu Ala Asn Ile Glu
                 245                 250                 255    
 Thr Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp
             260                 265                 270        
 Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp Thr Glu Glu Val Glu
         275                 280                 285            
 Ala Ile Leu Asn Gly Asp Val Asn Phe Gln Val Trp Ser Asp His His
     290                 295                 300                
 Arg Pro Ser Leu Ser Arg Ile Lys Leu Ala Ile Lys Tyr Glu Val Lys
 305                 310                 315                 320
 Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Met Trp
                 325                 330                 335    
 Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln Ser Ile Ala Val Lys Phe
             340                 345                 350        
 Leu Ala Val Phe Gly Val Ser Ile Gly Leu Pro Phe Leu Ala Ile Ala
         355                 360                 365            
 Tyr Trp Ile Ala Pro Cys Ser Lys Leu Gly Arg Thr Leu Arg Ser Pro
     370                 375                 380                
 Phe Met Lys Phe Val Ala His Ala Val Ser Phe Thr Ile Phe Leu Gly
 385                 390                 395                 400
 Leu Leu Val Val Asn Ala Ser Asp Arg Phe Glu Gly Val Lys Thr Leu
                 405                 410                 415    
 Pro Asn Glu Thr Phe Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys
             420                 425                 430        
 Thr Thr Gln Phe Ser Trp Thr Glu Met Leu Ile Met Lys Trp Val Leu
         435                 440                 445            
 Gly Met Ile Trp Ser Glu Cys Lys Glu Ile Trp Glu Glu Gly Pro Arg
     450                 455                 460                
 Glu Tyr Val Leu His Leu Trp Asn Leu Leu Asp Phe Gly Met Leu Ser
 465                 470                 475                 480
 Ile Phe Val Ala Ser Phe Thr Ala Arg Phe Met Ala Phe Leu Lys Ala
                 485                 490                 495    
 Thr Glu Ala Gln Leu Tyr Val Asp Gln His Val Gln Asp Asp Thr Leu
             500                 505                 510        
 His Asn Val Ser Leu Pro Pro Glu Val Ala Tyr Phe Thr Tyr Ala Arg
         515                 520                 525            
 Asp Lys Trp Trp Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr
     530                 535                 540                
 Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro
 545                 550                 555                 560
 Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val
                 565                 570                 575    
 Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala
             580                 585                 590        
 Phe Met Ile Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Arg Gly Ala Lys
         595                 600                 605            
 Tyr Asn Pro Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe
     610                 615                 620                
 Trp Ser Ile Phe Gly Leu Ser Glu Val Ile Ser Val Val Leu Lys Tyr
 625                 630                 635                 640
 Asp His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr
                 645                 650                 655    
 Asn Val Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile
             660                 665                 670        
 Asn Asn Ser Tyr Gln Glu Ile Glu Glu Asp Ala Asp Val Glu Trp Lys
         675                 680                 685            
 Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe Asp Glu Gly Arg Thr
     690                 695                 700                
 Leu Pro Ala Pro Phe Asn Leu Val Pro Ser Pro Lys Ser Phe Tyr Tyr
 705                 710                 715                 720
 Leu Ile Met Arg Ile Lys Met Cys Leu Ile Lys Leu Cys Lys Ser Lys
                 725                 730                 735    
 Ala Lys Ser Cys Glu Asn Asp Leu Glu Met Gly Met Leu Asn Ser Lys
             740                 745                 750        
 Phe Lys Lys Thr Arg Tyr Gln Ala Gly Met Arg Asn Ser Glu Asn Leu
         755                 760                 765            
 Thr Ala Asn Asn Thr Leu Ser Lys Pro Thr Arg Tyr Gln Lys Ile Met
     770                 775                 780                
 Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln Val Asp Arg Glu
 785                 790                 795                 800
 Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile
                 805                 810                 815    
 Ser Ser Leu Arg Tyr Glu Leu Leu Glu Glu Lys Ser Gln Ala Thr Gly
             820                 825                 830        
 Glu Leu Ala Asp Leu Ile Gln Gln Leu Ser Glu Lys Phe Gly Lys Asn
         835                 840                 845            
 Leu Asn Lys Asp His Leu Arg Val Asn Lys Gly Lys Asp Ile
     850                 855                 860        



      <210> 528
      <211> 102
      <212> PRT
      <213> Homo sapiens


      <400> 528
 Met Phe Leu Thr Ala Leu Leu Trp Arg Gly Arg Ile Pro Gly Arg Gln
   1               5                  10                  15    
 Trp Ile Gly Lys His Arg Arg Pro Arg Phe Val Ser Leu Arg Ala Lys
              20                  25                  30        
 Gln Asn Met Ile Arg Arg Leu Glu Ile Glu Ala Glu Asn His Tyr Trp
          35                  40                  45            
 Leu Ser Met Pro Tyr Met Thr Arg Glu Gln Glu Arg Gly His Ala Ala
      50                  55                  60                
 Val Arg Arg Arg Glu Ala Phe Glu Ala Ile Lys Ala Ala Ala Thr Ser
  65                  70                  75                  80
 Lys Phe Pro Pro His Arg Phe Ile Ala Asp Gln Leu Asp His Leu Asn
                  85                  90                  95    
 Val Thr Lys Lys Trp Ser
             100        



      <210> 529
      <211> 82
      <212> PRT
      <213> Homo sapiens


      <400> 529
 Met Leu Ser Arg Ala Val Glu Ser Leu His Ser Ala Asn Gln Arg Arg
   1               5                  10                  15    
 Ile Leu Lys Leu Ser Phe Leu Leu Phe Ser Pro Asp Val Pro Tyr Leu
              20                  25                  30        
 Ser His Thr His Pro Asn Asn Ile Ser Cys Ser Leu Leu Ser Leu Arg
          35                  40                  45            
 Gln Pro Leu Asn Phe Thr Gln Pro Gly Ala Leu Phe Thr Cys Leu Val
      50                  55                  60                
 Gln Ser Gln Phe Gly Leu Ile Leu Gln Pro Cys Ile Ser Gln Trp Gly
  65                  70                  75                  80
 Leu Ala
        



      <210> 530
      <211> 465
      <212> PRT
      <213> Homo sapiens


      <400> 530
 Met Leu Gly Ser Met Ala Arg Lys Lys Pro Arg Asn Thr Ser Arg Leu
   1               5                  10                  15    
 Pro Leu Ala Leu Asn Pro Leu Lys Ser Lys Asp Val Leu Ala Val Leu
              20                  25                  30        
 Ala Glu Arg Asn Glu Ala Ile Val Pro Val Gly Ala Trp Val Glu Pro
          35                  40                  45            
 Ala Ser Pro Gly Ser Ser Glu Ile Pro Ala Tyr Thr Ser Ala Tyr Leu
      50                  55                  60                
 Ile Glu Glu Glu Leu Lys Glu Gln Leu Arg Lys Lys Gln Glu Ala Leu
  65                  70                  75                  80
 Lys His Phe Gln Lys Gln Val Lys Tyr Arg Val Asn Gln Gln Ile Arg
                  85                  90                  95    
 Leu Arg Lys Lys Gln Gln Leu Gln Lys Ser Tyr Glu Arg Ala Gln Lys
             100                 105                 110        
 Glu Gly Ser Ile Ala Met Gln Ser Ser Ala Thr His Leu Thr Ser Lys
         115                 120                 125            
 Arg Thr Ser Val Phe Pro Asn Asn Leu Asn Val Ala Ile Gly Ser Ser
     130                 135                 140                
 Arg Leu Pro Pro Ser Leu Met Pro Gly Asp Gly Ile Glu Asp Glu Glu
 145                 150                 155                 160
 Asn Gln Asn Glu Leu Phe Gln Gln Gln Ala Gln Ala Leu Ser Glu Thr
                 165                 170                 175    
 Met Lys Gln Ala Arg His Arg Leu Ala Ser Phe Lys Thr Val Ile Lys
             180                 185                 190        
 Lys Lys Gly Ser Val Phe Pro Asp Asp Gly Arg Lys Ser Phe Leu Thr
         195                 200                 205            
 Arg Glu Glu Val Leu Ser Arg Lys Pro Ala Ser Thr Gly Ile Asn Thr
     210                 215                 220                
 Gly Ile Arg Gly Glu Leu Pro Ile Lys Val His Gln Gly Leu Leu Ala
 225                 230                 235                 240
 Ala Val Pro Tyr Gln Asn Tyr Met Glu Asn Gln Glu Leu Asp Tyr Glu
                 245                 250                 255    
 Glu Pro Asp Tyr Glu Glu Ser Ser Ser Leu Val Thr Asp Glu Lys Gly
             260                 265                 270        
 Lys Glu Asp Leu Phe Gly Arg Gly Gln Gln Asp Gln Gln Ala Ile His
         275                 280                 285            
 Ser Glu Asp Lys Asn Lys Pro Phe Ser Arg Val Gln Lys Val Lys Phe
     290                 295                 300                
 Lys Asn Pro Leu Phe Val Leu Met Glu Glu Glu Glu Gln Lys Gln Leu
 305                 310                 315                 320
 His Phe Glu Gly Leu Gln Asp Ile Leu Pro Glu Ala Gln Asp Tyr Phe
                 325                 330                 335    
 Leu Glu Ala Gln Gly Asp Leu Leu Glu Thr Gln Gly Asp Leu Thr Gly
             340                 345                 350        
 Ile Gln Ser Val Lys Pro Asp Thr Gln Ala Val Glu Met Lys Val Gln
         355                 360                 365            
 Val Thr Glu Pro Glu Gly Gln Ala Ile Glu Pro Glu Gly Gln Pro Ile
     370                 375                 380                
 Arg Thr Glu Thr Gln Gly Ile Met Leu Lys Ala Gln Ser Ile Glu Leu
 385                 390                 395                 400
 Glu Glu Gly Ser Ile Val Leu Lys Thr Gln Asp Phe Leu Pro Thr Asn
                 405                 410                 415    
 Gln Ala Leu Leu Thr Lys Asn Gln Asp Val Leu Leu Lys Asp His Cys
             420                 425                 430        
 Val Leu Pro Lys Asp Gln Ser Ile Leu Leu Lys Tyr Gln Asp Gln Asp
         435                 440                 445            
 Phe Pro Pro Arg Asp Gln His Val Leu His Lys Asp Gln Asp Ile Leu
     450                 455                 460                
 Pro
 465



      <210> 531
      <211> 400
      <212> PRT
      <213> Homo sapiens


      <400> 531
 Met Glu Asp Ile Val Gln Glu Asp Gly Glu Val Val Ala Glu Ser Gly
   1               5                  10                  15    
 Asn Ile Thr Pro Ala His Ser Gln Ala Ile Ile Pro Val Asp Val Asp
              20                  25                  30        
 Glu Glu Gln Ala Gly Pro Ser Gly Leu Gln Arg Val Val Lys Pro Thr
          35                  40                  45            
 Pro Ile Thr Val His Asp Ser Glu Ser Asp Asp Glu Glu Asp Ser Leu
      50                  55                  60                
 Glu Leu Gln Glu Val Trp Ile Pro Lys Asn Gly Thr Arg Arg Tyr Ser
  65                  70                  75                  80
 Glu Arg Glu Glu Lys Thr Gly Glu Ser Val Gln Ser Arg Glu Leu Ser
                  85                  90                  95    
 Glu Val Ala Lys Thr Lys Pro Arg His Ala Met Lys Arg Lys Arg Thr
             100                 105                 110        
 Ala Asp Lys Ser Thr Ser Thr Ser Asp Pro Val Ile Glu Asp Asp His
         115                 120                 125            
 Val Gln Val Leu Val Leu Lys Ser Lys Asn Leu Val Gly Val Thr Met
     130                 135                 140                
 Thr Asn Cys Gly Ile Thr Asp Leu Val Leu Lys Asp Cys Pro Lys Met
 145                 150                 155                 160
 Met Phe Ile His Ala Thr Arg Cys Arg Val Leu Lys His Leu Lys Val
                 165                 170                 175    
 Glu Asn Ala Pro Ile Val Asn Arg Phe Asp Tyr Ala Gln Cys Lys Lys
             180                 185                 190        
 Leu Asn Met Asp Gln Val Leu Asp Gln Ile Leu Arg Met Pro Pro Glu
         195                 200                 205            
 Arg Asn Arg Ile Ile Tyr Leu Arg Pro Met Gln Gln Val Asp Thr Leu
     210                 215                 220                
 Thr Leu Glu Gln Lys Leu Phe Ser Gly Pro Tyr Pro Tyr His Ile Cys
 225                 230                 235                 240
 Ile Ile His Glu Phe Ser Asn Pro Pro Asn Val Arg Asn Lys Val Arg
                 245                 250                 255    
 Ile Arg Ser Trp Met Asp Thr Ile Ala Asn Ile Asn Gln Glu Leu Ile
             260                 265                 270        
 Lys Tyr Glu Phe Phe Pro Glu Ala Thr Arg Ser Glu Glu Asp Leu Lys
         275                 280                 285            
 Lys Tyr Pro Lys Tyr Pro Trp Gly Arg Glu Ile Tyr Thr Leu Glu Gly
     290                 295                 300                
 Val Val Asp Gly Ala Pro Tyr Ser Met Ile Ser Asp Phe Pro Trp Leu
 305                 310                 315                 320
 Arg Ser Leu Arg Ala Ala Glu Pro Asn Ser Phe Ala Arg Tyr Asp Phe
                 325                 330                 335    
 Glu Asp Asp Glu Glu Ser Thr Ile Tyr Ala Pro Arg Arg Lys Gly Gln
             340                 345                 350        
 Leu Ser Ala Asp Ile Cys Met Glu Thr Ile Gly Glu Glu Ile Ser Glu
         355                 360                 365            
 Met Arg Gln Met Lys Lys Gly Val Phe Gln Arg Val Val Ala Ile Phe
     370                 375                 380                
 Ile His Tyr Cys Asp Val Asn Gly Glu Pro Val Glu Asp Asp Tyr Ile
 385                 390                 395                 400





      <210> 532
      <211> 512
      <212> PRT
      <213> Homo sapiens


      <400> 532
 Met Asn Lys Lys Thr Gln Pro His Pro Leu Glu Trp Asn Ser Phe Thr
   1               5                  10                  15    
 Glu Asp Lys Asn Ile Glu Lys Pro Gln Val Pro Phe Asp Ala Ile Glu
              20                  25                  30        
 Asn Lys Lys Ala Gly Val Pro Gln Ile Lys Asn Glu Asn Lys Glu Ile
          35                  40                  45            
 His Cys Ser Asp Asp Glu Asn Thr Pro Cys His Ile Lys Gln Ile Phe
      50                  55                  60                
 Thr His Pro His Leu Glu Leu Asn Pro Asp Phe His Pro Lys Ile Lys
  65                  70                  75                  80
 Asp Tyr Tyr Cys Glu Val Pro Phe Asp Val Val Thr Val Thr Ile Gly
                  85                  90                  95    
 Val Glu Thr Pro Lys Cys Leu Cys Lys Val His Leu Tyr Glu Gln Ala
             100                 105                 110        
 Gly Pro Ser Phe Ala Ser Tyr Pro Leu Gly Leu Gly Met Asn Lys Ile
         115                 120                 125            
 Ser Ile Phe Val Val Asp Glu Ser Pro Ala His Gly Glu Thr Leu Ile
     130                 135                 140                
 Thr Tyr Lys Leu Thr Ile Tyr Arg Glu Asp Arg Pro Ser Leu Pro Leu
 145                 150                 155                 160
 Phe Glu Ala Phe Thr Ala Cys Gly Phe Val Gln Asp Cys Gly Leu Leu
                 165                 170                 175    
 Ile His Pro Glu Glu Thr Cys Gly Leu Gln Pro Ile Ser Ser Asp Tyr
             180                 185                 190        
 Ile Glu Ala Ile Leu Gln Ser Glu Leu Lys Arg Cys Pro Ser Gly Asp
         195                 200                 205            
 Met Lys Gly Gln Trp Ile Val Pro Cys Leu Ser Cys Ser Asp Asn Arg
     210                 215                 220                
 Thr Cys Asp Trp Arg Glu Ile Thr Trp Gln Pro His Asn Cys Gln Tyr
 225                 230                 235                 240
 Gly Val Leu Thr Lys Pro Gln Leu Gln Gln Cys Leu Gly Gly Arg Lys
                 245                 250                 255    
 Ile Leu Phe Ile Gly Asp Ser Thr Asn Arg Gly Ile Met Tyr Tyr Leu
             260                 265                 270        
 Ile Glu Arg Leu Asn Glu Thr Leu Gln Glu Trp Gln Lys Val His Gly
         275                 280                 285            
 Thr Lys Phe Tyr His Asn Val Asn Gly Gly Lys Thr Leu Ile Ser Tyr
     290                 295                 300                
 Ser Tyr Tyr Pro Gln Phe Trp Ile Ser Pro Ser Leu Arg Pro Thr Phe
 305                 310                 315                 320
 Glu Asn Ala Leu Glu His Leu Leu Gln Arg Ser Arg Pro Leu Glu Asn
                 325                 330                 335    
 Thr Gly Gln Thr Val Leu Val Val Gly Gly Val Gln Trp Leu Asn Ser
             340                 345                 350        
 Asn His Leu Gln Ile Ile His Lys Val Leu Lys Arg Glu Asn Leu Leu
         355                 360                 365            
 Asn Ile Leu Val Ile Ile Lys Thr Leu Gly Ile Gly Phe His Leu Pro
     370                 375                 380                
 Val Asp Gly Val His Phe Leu Thr Gln Ser Glu Val Gln Asn Leu Trp
 385                 390                 395                 400
 Lys Glu Asn Leu Ile Ile Leu Asp Thr Ala Lys Lys His Gly Tyr Glu
                 405                 410                 415    
 Val Val Asp Thr Phe Thr Ile Thr Met Gly Arg Tyr Lys Glu Phe Leu
             420                 425                 430        
 Gln Gly Lys Cys Gly Cys His Phe His Glu Val Val Lys Ser Lys Leu
         435                 440                 445            
 Ser Lys Glu Tyr Asn Phe Ile Lys Met Lys Arg Ser Arg Asn His Ile
     450                 455                 460                
 Met Gly Arg Tyr Phe Ser Asn Gln Ser Lys Leu Gln Gln Gly Thr Val
 465                 470                 475                 480
 Thr Asn Phe Arg Ser Pro Tyr His Val Arg Gly Pro Ile Asn Gln Val
                 485                 490                 495    
 Cys Ser Glu Ile Leu Leu Ser Arg Met Cys Ala Asn Lys Arg Thr Met
             500                 505                 510        





      <210> 533
      <211> 66
      <212> PRT
      <213> Homo sapiens


      <400> 533
 Met Ala Pro Pro Val Arg Tyr Cys Ile Pro Gly Glu Arg Leu Cys Asn
   1               5                  10                  15    
 Leu Glu Glu Gly Ser Pro Gly Ser Gly Thr Tyr Thr Arg His Gly Tyr
              20                  25                  30        
 Ile Phe Ser Ser Leu Ala Gly Cys Leu Met Lys Ser Ser Glu Asn Gly
          35                  40                  45            
 Ala Val Lys Glu Ala Ala Cys His Leu Pro Ser Val Phe Pro Leu Gly
      50                  55                  60                
 Cys Pro
  65    



      <210> 534
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 534
 Met Gly Ala Arg Ser Ser Leu Arg Pro Pro Glu Lys Ala Thr Glu Arg
   1               5                  10                  15    
 Gln Gln Ser Phe Pro Gln Leu Glu Asn His Arg Ala Gln Ile Ala Met
              20                  25                  30        
 Leu Arg Pro Phe Cys His Leu Ala Thr Glu Thr Ser Asn Phe Asn Leu
          35                  40                  45            
 Phe Val Ser Gly Ala Leu Arg Asn Leu Ser Cys His Pro Phe Leu Ser
      50                  55                  60                
 Leu Leu Pro Asn Phe
  65                



      <210> 535
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 535
 Met Asp Ile Pro Tyr His Phe Ala Leu Pro Tyr Asn Gln Gly Thr Leu
   1               5                  10                  15    
 Pro Ile Arg Val Tyr Cys Arg Glu Arg Thr Ala Lys Gln Pro Pro Ser
              20                  25                  30        
 Leu Asn Leu Gln Leu Ile Ile Cys Asn Arg Phe Ser Leu Asn Pro Arg
          35                  40                  45            
 His Arg Met Gly Asn Gly Phe Pro His Gln Val Leu Arg Gly Leu Gln
      50                  55                  60                
 Glu Val Thr Pro Gly Gln Gly Arg Leu Gln
  65                  70                



      <210> 536
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 536
 Met Trp Ile Ile Asp Pro Phe Asp Phe Asp Glu His Phe Asp Lys Cys
   1               5                  10                  15    
 Leu Asn Tyr Leu Pro His Tyr Arg Thr Ser Ala Glu Phe His Arg Thr
              20                  25                  30        
 Ala Trp Met Leu His Leu Cys His Leu Ile Gln Glu Ala Ala Leu Tyr
          35                  40                  45            
 Ile Ser Thr Val Ile Glu Lys Gly Gly Gly Gln Leu Ser Arg Ile Phe
      50                  55                  60                
 Met Phe Glu Lys Val Ser Thr Arg Glu Leu Asp Pro Ser Ala Leu Lys
  65                  70                  75                  80
 Gly Cys Met Phe Leu Cys Val Phe Gly Leu Pro Gly Asp Lys Lys Pro
                  85                  90                  95    
 Asp Glu Cys Ala His Ala Leu Glu Ser Ser Phe Ser Ile Phe Ser Phe
             100                 105                 110        
 Cys Trp Glu Asn Leu Ala Lys Thr Asn
         115                 120    



      <210> 537
      <211> 45
      <212> PRT
      <213> Homo sapiens


      <400> 537
 Met Ala Trp Val Thr Ser Tyr Gly Pro Leu Glu Asp Glu Ser Asn Pro
   1               5                  10                  15    
 Ser His Trp Phe Phe Phe Ala Asn Ser Phe Ala Phe Ile Phe Leu Ile
              20                  25                  30        
 Thr Ile Asn Ser Ile Phe His Val Leu Arg Ala Pro Gly
          35                  40                  45



      <210> 538
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 538
 Met Ala Ser Ala Ser Ala Arg Gly Asn Gln Asp Lys Asp Ala His Phe
   1               5                  10                  15    
 Pro Pro Pro Ser Lys Gln Ser Leu Leu Phe Cys Pro Lys Ser Lys Leu
              20                  25                  30        
 His Ile His Arg Ala Glu Ile Ser Lys Ile Met Arg Glu Cys Gln Glu
          35                  40                  45            
 Glu Ser Phe Trp Lys Arg Ala Leu Pro Phe Ser Leu Val Ser Met Leu
      50                  55                  60                
 Val Thr Gln Gly Leu Val Tyr Gln Gly Tyr Leu Ala Ala Asn Ser Arg
  65                  70                  75                  80
 Phe Gly Ser Leu Pro Lys Val Ala Leu Ala Gly Leu Leu Gly Phe Gly
                  85                  90                  95    
 Leu Gly Lys Val Ser Tyr Ile Gly Val Cys Gln Ser Lys Phe His Phe
             100                 105                 110        
 Phe
    



      <210> 539
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 539
 Met Thr Thr Thr Thr Thr Phe Lys Gly Val Asp Pro Asn Ser Arg Asn
   1               5                  10                  15    
 Ser Ser Arg Val Leu Arg Pro Pro Gly Gly Gly Ser Asn Phe Ser Leu
              20                  25                  30        
 Gly Phe Asp Glu Pro Thr Glu Gln Pro Val Arg Lys Asn Lys Met Ala
          35                  40                  45            
 Ser Asn Ile Phe Gly Thr Pro Glu Glu Asn Gln Ala Ser Trp Ala Lys
      50                  55                  60                
 Ser Ala Gly Ala Lys Ser Ser Gly Gly Arg Glu Asp Leu Glu Ser Ser
  65                  70                  75                  80
 Gly Leu Gln Arg Arg Asn Ser Ser Glu Ala Ser Ser Gly Asp Phe Leu
                  85                  90                  95    
 Asp Leu Lys Gly Glu Gly Asp Ile His Glu Asn Val Asp Thr Asp Leu
             100                 105                 110        
 Pro Gly Ser Leu Gly Gln Ser Glu Glu Lys Pro Val Pro Ala Ala Pro
         115                 120                 125            
 Val Pro Ser Pro Val Ala Arg Ala Gln Cys His Pro Glu Glu Ser Pro
     130                 135                 140                
 Gly Gly Lys Ser Ser Leu Val Leu Gly
 145                 150            



      <210> 540
      <211> 166
      <212> PRT
      <213> Homo sapiens


      <400> 540
 Met Asp Leu Lys Asp Lys Asn Gly Gly Pro Gly Arg Cys Asn Ser His
   1               5                  10                  15    
 Arg Leu Lys Val Ser Ser Gly Leu Cys Lys Thr His Glu Ile Gly Phe
              20                  25                  30        
 Asp Pro Leu Ala Leu Lys Cys Pro Leu Arg Ser Arg Thr Ala Pro Trp
          35                  40                  45            
 Trp Pro Leu Asp Arg Val Ser Phe Asp Leu His His Leu Val Ile Gly
      50                  55                  60                
 Asn Phe Phe Val Gly Asn Arg Lys Ile Phe Leu Asp Tyr Leu Val Tyr
  65                  70                  75                  80
 Gly Phe Ala His Asn Asn Arg Trp Lys Leu Leu Val Gln Ser Trp Ser
                  85                  90                  95    
 Asp Gly Cys Val His Arg Thr Phe Gly Leu Val Lys Ser Phe Ser Lys
             100                 105                 110        
 Ala Ser Phe Cys Ile Phe Ile Thr Lys Gln Arg Lys Ser Ser Glu Asp
         115                 120                 125            
 Leu Ala Leu Lys Gln Ile Cys Ala Asn Thr Ala Arg Val Ile Leu Lys
     130                 135                 140                
 Leu Lys His Phe His Phe Val Ser Tyr Met Cys Thr Phe Leu Phe Thr
 145                 150                 155                 160
 Cys Glu Asn Gly His Leu
                 165    



      <210> 541
      <211> 322
      <212> PRT
      <213> Homo sapiens


      <400> 541
 Met Ala Gly Ile Gly Asp Leu Leu Asp Ala Val Thr Glu Ala Gly Ala
   1               5                  10                  15    
 Ala Ile Gly Gly His Leu Pro Ala Ala Thr Ala Phe Lys Pro Arg Leu
              20                  25                  30        
 Ala Lys Ala Ala Val Ile Ser Glu Arg Leu Ser Ala Cys Pro Pro Ser
          35                  40                  45            
 Arg Arg Val Ala Gly Ala Cys Ala Ser Arg Ser Thr Ser Leu Leu Leu
      50                  55                  60                
 Ser Arg Pro Arg Pro Gly Gly Pro Glu Arg Glu Ala Gly Thr Met Phe
  65                  70                  75                  80
 Arg Arg Lys Leu Thr Ala Leu Asp Tyr His Asn Pro Ala Gly Phe Asn
                  85                  90                  95    
 Cys Lys Asp Glu Thr Glu Phe Arg Asn Phe Ile Val Trp Leu Glu Asp
             100                 105                 110        
 Gln Lys Ile Arg His Tyr Lys Ile Glu Asp Arg Gly Asn Leu Arg Asn
         115                 120                 125            
 Ile His Ser Ser Asp Trp Pro Lys Phe Phe Glu Lys Tyr Leu Arg Asp
     130                 135                 140                
 Val Asn Cys Pro Phe Lys Ile Gln Asp Arg Gln Glu Ala Ile Asp Trp
 145                 150                 155                 160
 Leu Leu Gly Leu Ala Val Arg Leu Glu Tyr Gly Asp Asn Ala Glu Lys
                 165                 170                 175    
 Tyr Lys Asp Leu Val Pro Asp Asn Ser Lys Thr Ala Asp Asn Ala Thr
             180                 185                 190        
 Lys Asn Ala Glu Pro Leu Ile Asn Leu Asp Val Asn Asn Pro Asp Phe
         195                 200                 205            
 Lys Ala Gly Val Met Ala Leu Ala Asn Leu Leu Gln Ile Gln Arg His
     210                 215                 220                
 Asp Asp Tyr Leu Val Met Leu Lys Ala Ile Arg Ile Leu Val Gln Glu
 225                 230                 235                 240
 Arg Leu Thr Gln Asp Ala Val Ala Lys Ala Asn Gln Thr Lys Glu Gly
                 245                 250                 255    
 Leu Pro Val Ala Leu Asp Lys His Ile Leu Gly Phe Asp Thr Gly Asp
             260                 265                 270        
 Ala Val Leu Asn Glu Ala Ala Gln Ile Leu Arg Leu Leu His Ile Glu
         275                 280                 285            
 Glu Leu Arg Glu Leu Gln Thr Lys Ile Asn Glu Ala Ile Val Ala Val
     290                 295                 300                
 Gln Ala Ile Ile Ala Asp Pro Lys Thr Asp His Arg Leu Gly Lys Val
 305                 310                 315                 320
 Gly Arg
        



      <210> 542
      <211> 326
      <212> PRT
      <213> Homo sapiens


      <400> 542
 Met Pro Cys Ser Thr Glu Thr Trp Arg Lys Ser Asn Leu Lys Phe Thr
   1               5                  10                  15    
 Phe Gln Thr Trp Ser Pro Gln Pro Ser Asp Pro Leu Lys Val Ser Pro
              20                  25                  30        
 Leu Tyr Trp Gly Gly Thr Gly Gly Ser Val Leu Gly Gly Leu Arg Arg
          35                  40                  45            
 Leu Leu Lys Gly Ser Thr Gln Glu Leu Met Asp Ser Ser Pro Arg Pro
      50                  55                  60                
 Ser Pro Ala Met Gly Ala Trp Gly Ala Ser Pro Asp Ala Gly Pro Ala
  65                  70                  75                  80
 Ser Pro Arg Tyr Met Tyr Ser Val Glu Met Arg Ser Ile Trp Lys Pro
                  85                  90                  95    
 Thr Arg Cys Trp Thr Leu Cys Met Leu Leu Arg Ser Thr Ser Ser Gln
             100                 105                 110        
 His Trp Gln Lys Pro Val Ser Thr Phe Trp Arg Gln Val Trp Lys Pro
         115                 120                 125            
 Arg Thr Thr Ala Ser Cys Cys Pro Arg Ala Gly Cys Leu Arg Ser Pro
     130                 135                 140                
 Ser Trp Thr Gln Arg Cys Trp Glu Val Ile Asp Ala Gln Ala Glu Met
 145                 150                 155                 160
 Ala Leu Arg Ser Glu Gly Phe Cys Glu Ile Asp Arg Gln Thr Leu Glu
                 165                 170                 175    
 Ile Ile Val Thr Arg Glu Ala Leu Asn Thr Lys Glu Ala Val Val Phe
             180                 185                 190        
 Glu Ala Val Leu Asn Trp Ala Glu Ala Glu Cys Lys Arg Gln Gly Leu
         195                 200                 205            
 Pro Ile Thr Pro Arg Asn Lys Arg His Val Leu Gly Arg Ala Leu Tyr
     210                 215                 220                
 Leu Val Arg Asn Ser Asn His Asp Pro Arg Gly Val Cys Gln Arg Arg
 225                 230                 235                 240
 Cys Pro Val Arg His Pro Asp Ser Gly Gly Asp Pro Gln His Leu Pro
                 245                 250                 255    
 Val Val His Gly His Gln Gln Ala Pro Pro Gly Leu Ser Pro Asp Gln
             260                 265                 270        
 Glu Glu Gly Pro Arg Pro Ala Glu Val Pro Pro Ile Pro Val Phe Cys
         275                 280                 285            
 Leu Pro Gln Gln Pro Val Ala Val Pro Arg Ala Leu Arg Gln His Pro
     290                 295                 300                
 Val Cys Ser Gly Gln Lys Gly Ile Tyr Cys Arg Ala Gly Pro Val Trp
 305                 310                 315                 320
 Leu Gln Leu Trp Glu Gly
                 325    



      <210> 543
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 543
 Met Ser Gly Ile Ala Leu Ser Arg Leu Ala Gln Glu Arg Lys Ala Trp
   1               5                  10                  15    
 Arg Lys Asp His Pro Phe Gly Phe Val Ala Val Pro Thr Lys Asn Pro
              20                  25                  30        
 Asp Gly Thr Met Asn Leu Met Asn Trp Glu Cys Ala Ile Pro Gly Lys
          35                  40                  45            
 Lys Gly Val Arg Gly Ala Ala Ala Ser Cys Leu Ser Gly Leu Ser Arg
      50                  55                  60                
 Cys Val Arg Gln Cys His Gly Asp Thr Pro Leu Arg Ser Leu Pro Ser
  65                  70                  75                  80
 Val Thr Gln Pro Leu Ser Gln Ala Ala Val Asn Ser Ser Asp Pro Gln
                  85                  90                  95    
 Leu Trp Pro Gly Pro Arg Pro Val Arg Thr
             100                 105    



      <210> 544
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 544
 Met Ala Ala Ala Ala Val Gln Gly Gly Arg Ser Gly Gly Ser Gly Gly
   1               5                  10                  15    
 Cys Ser Gly Ala Gly Gly Ala Ser Asn Cys Gly Thr Gly Ser Gly Arg
              20                  25                  30        
 Ser Gly Leu Leu Asp Lys Trp Lys Ile Asp Asp Lys Pro Val Lys Ile
          35                  40                  45            
 Asp Lys Trp Asp Gly Ser Ala Val Lys Asn Ser Leu Asp Asp Ser Ala
      50                  55                  60                
 Lys Lys Val Leu Leu Glu Lys Tyr Lys Tyr Val Glu Asn Phe Gly Leu
  65                  70                  75                  80
 Ile Asp Gly Arg Leu Thr Ile Cys Thr Ile Ser Cys Phe Phe Ala Ile
                  85                  90                  95    
 Val Ala Leu Ile Trp Asp Tyr Met His Pro Phe Pro Glu Ser Lys Pro
             100                 105                 110        
 Val Leu Ala Leu Cys Val Ile Ser Tyr Phe Val Met Met Gly Ile Leu
         115                 120                 125            
 Thr Ile Tyr Thr Ser Tyr Lys Glu Lys Ser Ile Phe Leu Val Ala His
     130                 135                 140                
 Arg Lys Asp Pro Thr Gly Met Asp Pro Asp Asp Ile Trp Gln Leu Ser
 145                 150                 155                 160
 Ser Ser Leu Lys Arg Phe Asp Asp Lys Tyr Thr Leu Lys Leu Thr Phe
                 165                 170                 175    
 Ile Ser Gly Arg Thr Lys Gln Gln Arg Glu Ala Glu Phe Thr Lys Ser
             180                 185                 190        
 Ile Ala Lys Phe Phe Asp His Ser Gly Thr Leu Val Met Asp Ala Tyr
         195                 200                 205            
 Glu Pro Glu Ile Ser Arg Leu His Asp Ser Leu Ala Ile Glu Arg Lys
     210                 215                 220                
 Ile Lys
 225    



      <210> 545
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 545
 Met Ala Thr Tyr Ser Leu Ala Asn Glu Arg Leu Arg Ala Leu Glu Asp
   1               5                  10                  15    
 Ile Glu Arg Glu Ile Gly Ala Ile Leu Gln Asn Ala Gly Thr Val Ile
              20                  25                  30        
 Leu Glu Leu Ser Lys Glu Lys Thr Asn Glu Arg Leu Leu Asp Arg Gln
          35                  40                  45            
 Ala Ala Ala Phe Thr Ala Ser Val Gln His Val Glu Ala Glu Leu Ser
      50                  55                  60                
 Ala Gln Ile Arg Tyr Leu Thr Gln Val Ala Thr Gly Gln Pro His Glu
  65                  70                  75                  80
 Gly Ser Ser Tyr Ser Ser Arg Lys Asp Cys Gln Met Ala Leu Lys Arg
                  85                  90                  95    
 Val Asp Tyr Ala Arg Leu Lys Leu Ser Asp Val Ala Arg Thr Cys Glu
             100                 105                 110        
 Gln Met Leu Glu Asn
         115        



      <210> 546
      <211> 967
      <212> PRT
      <213> Homo sapiens


      <400> 546
 Met Leu Arg Gln Tyr Gly Pro Asn Val Pro Glu Pro Ile Leu Gln Lys
   1               5                  10                  15    
 Leu Val Ala Ala Phe Gly Glu Leu Arg Ser Leu Ala Asp Gln Gly Ile
              20                  25                  30        
 Ile Asn Tyr Pro Tyr Ser Thr Arg Glu Val Val Asn Ile Val Lys His
          35                  40                  45            
 Leu Gln Lys Phe Pro Thr Glu Gly Leu Ser Ser Val Val Arg Asn Val
      50                  55                  60                
 Phe Asp Phe Asp Ser Tyr Asn Asn Asp Met Arg Glu Ile Leu Ile Asn
  65                  70                  75                  80
 Thr Leu His Lys Tyr Gly Ile Pro Ile Gly Ala Lys Pro Thr Ser Val
                  85                  90                  95    
 Gln Leu Ala Lys Glu Leu Thr Leu Pro Glu Gln Thr Phe Met Gly Tyr
             100                 105                 110        
 Trp Thr Ile Gly Gln Ala Arg Ser Gly Met Gln Lys Leu Leu Cys Pro
         115                 120                 125            
 Val Glu Thr His His Ile Asp Ile Lys Gly Pro Ala Leu Ile Asn Ile
     130                 135                 140                
 Gln Glu Tyr Pro Ile Glu Arg His Glu Glu Arg Ser Leu Asn Phe Thr
 145                 150                 155                 160
 Glu Glu Cys Ala Ser Trp Arg Ile Pro Leu Asp Glu Ile Asn Ile Ile
                 165                 170                 175    
 Cys Asp Ile Ala Thr Ser His Glu Asn Glu Gln Asn Thr Leu Tyr Val
             180                 185                 190        
 Val Thr Cys Asn Pro Ala Ser Leu Tyr Phe Met Asn Met Thr Gly Lys
         195                 200                 205            
 Ser Gly Phe Phe Val Asp Phe Phe Asp Ile Phe Pro Arg Thr Ala Asn
     210                 215                 220                
 Gly Val Trp His Pro Phe Val Thr Val Ala Pro Leu Gly Ser Pro Leu
 225                 230                 235                 240
 Lys Gly Gln Val Val Leu His Glu Gln Gln Ser Asn Val Ile Leu Leu
                 245                 250                 255    
 Leu Asp Thr Thr Gly Arg Ala Leu His Arg Leu Ile Leu Pro Ser Glu
             260                 265                 270        
 Lys Phe Thr Ser Lys Lys Pro Phe Trp Trp Asn Lys Glu Glu Ala Glu
         275                 280                 285            
 Thr Tyr Lys Met Cys Lys Glu Phe Ser His Lys Asn Trp Leu Val Phe
     290                 295                 300                
 Tyr Lys Glu Lys Gly Asn Ser Leu Thr Val Leu Asp Val Leu Glu Gly
 305                 310                 315                 320
 Arg Thr His Thr Ile Ser Leu Pro Ile Asn Leu Lys Thr Val Phe Leu
                 325                 330                 335    
 Val Ala Glu Asp Lys Trp Leu Leu Val Glu Ser Lys Thr Asn Gln Lys
             340                 345                 350        
 Tyr Leu Leu Thr Lys Pro Ala His Ile Glu Ser Glu Gly Ser Gly Val
         355                 360                 365            
 Cys Gln Leu Tyr Val Leu Lys Glu Glu Pro Pro Ser Thr Gly Phe Gly
     370                 375                 380                
 Val Thr Gln Glu Thr Glu Phe Ser Ile Pro His Lys Ile Ser Ser Asp
 385                 390                 395                 400
 Gln Leu Ser Ser Glu His Leu Ser Ser Ala Val Glu Gln Lys Ile Ala
                 405                 410                 415    
 Ser Pro Asn Arg Ile Leu Ser Asp Glu Lys Asn Tyr Ala Thr Ile Val
             420                 425                 430        
 Val Gly Phe Pro Asp Leu Met Ser Pro Ser Glu Val Tyr Ser Trp Lys
         435                 440                 445            
 Arg Pro Ser Ser Leu His Lys Arg Ser Gly Thr Asp Thr Ser Phe Tyr
     450                 455                 460                
 Arg Gly Lys Lys Lys Arg Gly Thr Pro Lys Gln Ser Asn Cys Val Thr
 465                 470                 475                 480
 Leu Leu Asp Thr Asn Gln Val Val Arg Ile Leu Pro Pro Gly Glu Val
                 485                 490                 495    
 Pro Leu Lys Asp Ile Tyr Pro Lys Asp Val Thr Pro Pro Gln Thr Ser
             500                 505                 510        
 Gly Tyr Ile Glu Val Thr Asp Leu Gln Ser Lys Lys Leu Arg Tyr Ile
         515                 520                 525            
 Pro Ile Pro Arg Ser Glu Ser Leu Ser Pro Tyr Thr Thr Trp Leu Ser
     530                 535                 540                
 Thr Ile Ser Asp Thr Asp Ala Leu Leu Ala Glu Trp Asp Lys Ser Gly
 545                 550                 555                 560
 Val Val Thr Val Asp Met Gly Gly His Ile Arg Leu Trp Glu Thr Gly
                 565                 570                 575    
 Leu Glu Arg Leu Gln Arg Ser Leu Met Glu Trp Arg Asn Met Ile Gly
             580                 585                 590        
 Gln Asp Asp Arg Asn Met Gln Ile Thr Ile Asn Arg Asp Ser Gly Glu
         595                 600                 605            
 Asp Val Ser Ser Pro Lys His Gly Lys Glu Asp Pro Asp Asn Met Pro
     610                 615                 620                
 His Val Gly Gly Asn Thr Trp Ala Gly Gly Thr Gly Gly Arg Asp Thr
 625                 630                 635                 640
 Ala Gly Leu Gly Gly Lys Gly Gly Pro Tyr Arg Leu Asp Ala Gly His
                 645                 650                 655    
 Thr Val Tyr Gln Val Ser Gln Ala Glu Lys Asp Ala Val Pro Glu Glu
             660                 665                 670        
 Val Lys Arg Ala Ala Arg Glu Met Gly Gln Arg Ala Phe Gln Gln Arg
         675                 680                 685            
 Leu Lys Glu Ile Gln Met Ser Glu Tyr Asp Ala Ala Thr Tyr Glu Arg
     690                 695                 700                
 Phe Ser Gly Ala Val Arg Arg Gln Val His Ser Leu Arg Ile Ile Leu
 705                 710                 715                 720
 Asp Asn Leu Gln Ala Lys Gly Lys Glu Arg Gln Trp Leu Arg His Gln
                 725                 730                 735    
 Ala Thr Gly Glu Leu Asp Asp Ala Lys Ile Ile Asp Gly Leu Thr Gly
             740                 745                 750        
 Glu Lys Ala Ile Tyr Lys Arg Arg Gly Glu Leu Glu Pro Gln Leu Gly
         755                 760                 765            
 Ser Pro Gln Gln Lys Pro Lys Arg Leu Arg Leu Val Val Asp Val Ser
     770                 775                 780                
 Gly Ser Met Tyr Arg Phe Asn Arg Met Asp Gly Arg Leu Glu Arg Thr
 785                 790                 795                 800
 Met Glu Ala Val Cys Met Val Met Glu Ala Phe Glu Asn Tyr Glu Glu
                 805                 810                 815    
 Lys Phe Gln Tyr Asp Ile Val Gly His Ser Gly Asp Gly Tyr Asn Ile
             820                 825                 830        
 Gly Leu Val Pro Met Asn Lys Ile Pro Lys Asp Asn Lys Gln Arg Leu
         835                 840                 845            
 Glu Ile Leu Lys Thr Met His Ala His Ser Gln Phe Cys Met Ser Gly
     850                 855                 860                
 Asp His Thr Leu Glu Gly Thr Glu His Ala Ile Lys Glu Ile Val Lys
 865                 870                 875                 880
 Glu Glu Ala Asp Glu Tyr Phe Val Ile Val Leu Ser Asp Ala Asn Leu
                 885                 890                 895    
 Ser Arg Tyr Gly Ile His Pro Ala Lys Phe Ala Gln Ile Leu Thr Arg
             900                 905                 910        
 Asp Pro Gln Val Asn Ala Phe Ala Ile Phe Ile Gly Ser Leu Gly Asp
         915                 920                 925            
 Gln Ala Thr Arg Leu Gln Arg Thr Leu Pro Ala Gly Arg Ser Phe Val
     930                 935                 940                
 Ala Met Asp Thr Lys Asp Ile Pro Gln Ile Leu Gln Gln Ile Phe Thr
 945                 950                 955                 960
 Ser Thr Met Leu Ser Ser Val
                 965        



      <210> 547
      <211> 183
      <212> PRT
      <213> Homo sapiens


      <400> 547
 Met Ala Asp Thr Gln Cys Cys Pro Pro Pro Cys Glu Phe Ile Ser Ser
   1               5                  10                  15    
 Ala Gly Thr Asp Leu Ala Leu Gly Met Gly Trp Asp Ala Thr Leu Cys
              20                  25                  30        
 Leu Leu Pro Phe Thr Gly Phe Gly Lys Cys Ala Gly Ile Trp Asn His
          35                  40                  45            
 Met Asp Glu Glu Pro Asp Asn Gly Asp Asp Arg Gly Ser Arg Arg Thr
      50                  55                  60                
 Thr Gly Gln Gly Arg Lys Trp Ala Ala His Gly Thr Met Ala Ala Pro
  65                  70                  75                  80
 Arg Val His Thr Asp Tyr His Pro Gly Gly Gly Ser Ala Cys Ser Ser
                  85                  90                  95    
 Val Lys Val Arg Ser His Val Gly His Thr Gly Val Phe Phe Phe Val
             100                 105                 110        
 Asp Gln Asp Pro Leu Ala Val Ser Leu Thr Ser Gln Ser Leu Ile Pro
         115                 120                 125            
 Pro Leu Ile Lys Pro Gly Leu Leu Lys Ala Trp Gly Phe Leu Leu Leu
     130                 135                 140                
 Cys Ala Gln Pro Ser Ala Asn Gly His Ser Leu Cys Cys Leu Leu Tyr
 145                 150                 155                 160
 Thr Asp Leu Val Ser Ser His Glu Leu Ser Pro Phe Leu Thr Pro Thr
                 165                 170                 175    
 Cys Ser Val Leu Arg Ala Leu
             180            



      <210> 548
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 548
 Met Glu Asn Pro Thr Ser Thr Pro Thr Leu Pro Cys Phe Phe Phe Phe
   1               5                  10                  15    
 Phe Ser Pro Arg Ser Leu Asp Val Leu Thr Pro Pro His Cys Leu Ser
              20                  25                  30        
 Ser Leu Gly Gln Ala Gly Thr Phe Glu Glu Asp Lys Ala Phe Leu Asp
          35                  40                  45            
 Tyr Pro Ser Tyr Ser Val Ser Leu Phe Leu Thr Gln Arg Gly Arg Gln
      50                  55                  60                
 Asn Gln Ser Gly Leu Phe Gln
  65                  70    



      <210> 549
      <211> 313
      <212> PRT
      <213> Homo sapiens


      <400> 549
 Met Ile Gln His Asn Cys Ser Arg Gln Gly Pro Thr Ala Pro Pro Pro
   1               5                  10                  15    
 Pro Arg Gly Pro Ala Leu Pro Gly Ala Gly Ser Gly Leu Pro Ala Pro
              20                  25                  30        
 Asp Pro Cys Asp Tyr Glu Gly Arg Phe Ser Arg Leu His Gly Arg Pro
          35                  40                  45            
 Pro Gly Phe Leu His Cys Ala Ser Phe Gly Asp Pro His Val Arg Ser
      50                  55                  60                
 Phe His His His Phe His Thr Cys Arg Val Gln Gly Ala Trp Pro Leu
  65                  70                  75                  80
 Leu Asp Asn Asp Phe Leu Phe Val Gln Ala Thr Ser Ser Pro Met Ala
                  85                  90                  95    
 Leu Gly Ala Asn Ala Thr Ala Thr Arg Lys Leu Thr Ile Ile Phe Lys
             100                 105                 110        
 Asn Met Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val Asp
         115                 120                 125            
 Asn Leu Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp Arg
     130                 135                 140                
 Pro Gly Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn His
 145                 150                 155                 160
 Val Glu Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg Gln
                 165                 170                 175    
 Thr Ala Gly Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val Ala
             180                 185                 190        
 Met Ala Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly Cys
         195                 200                 205            
 Pro Pro Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly Ala
     210                 215                 220                
 Ile Thr Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro Val
 225                 230                 235                 240
 Glu Asp Ala Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser Gly
                 245                 250                 255    
 Asp Pro Asn Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala Arg
             260                 265                 270        
 Ala Phe Leu Pro Asp Leu Glu Lys Leu His Leu Phe Pro Ser Asp Ala
         275                 280                 285            
 Gly Val Pro Leu Ser Ser Ala Thr Leu Leu Ala Pro Leu Leu Ser Gly
     290                 295                 300                
 Leu Phe Val Leu Trp Leu Cys Ile Gln
 305                 310            



      <210> 550
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 550
 Met Ser Lys Asn Thr Val Ser Ser Ala Arg Phe Arg Lys Val Asp Val
   1               5                  10                  15    
 Asp Glu Tyr Asp Glu Asn Lys Phe Val Asp Glu Glu Asp Gly Gly Asp
              20                  25                  30        
 Gly Gln Ala Gly Pro Asp Glu Gly Glu Val Asp Ser Cys Leu Arg Gln
          35                  40                  45            
 Gly Asn Met Thr Ala Ala Leu Gln Ala Ala Leu Lys Asn Pro Pro Ile
      50                  55                  60                
 Asn Thr Lys Ser Gln Ala Val Lys Val Leu Ile Ser Phe Lys Ala Asn
  65                  70                  75                  80
 Asp Ile Glu Lys Ala Val Gln Ser Leu Asp Lys Asn Gly Val Asp Leu
                  85                  90                  95    
 Leu Met Lys Tyr Ile Tyr Lys Gly Phe Glu Ser Pro Ser Asp Asn Ser
             100                 105                 110        
 Ser Ala Met Leu Leu Gln Trp His Glu Lys Ala Leu Ala Ala Gly Gly
         115                 120                 125            
 Val Gly Ser Ile Val Arg Val Leu Thr Ala Arg Lys Thr Val
     130                 135                 140        



      <210> 551
      <211> 440
      <212> PRT
      <213> Homo sapiens


      <400> 551
 Met Pro Arg Arg Lys Ala Ala Ser Asn Ser Phe Arg Thr Val Val Asp
   1               5                  10                  15    
 Met Ser Glu Asp Gly Ala Gly Arg Pro His Leu Leu Glu Glu Glu Gly
              20                  25                  30        
 Asp Cys His Val Ser Phe Leu His Ala Asp Gly Lys Ala Cys Gly Leu
          35                  40                  45            
 Cys Ser Leu Ala Ala Ser Val Pro Cys Ser Val Ala Pro Glu Lys Ser
      50                  55                  60                
 Val Cys Arg Pro Gln Pro Leu Gln Val Arg Arg Thr Phe Ser Leu Asp
  65                  70                  75                  80
 Thr Ile Leu Ser Ser Tyr Leu Leu Gly Gln Trp Pro Arg Asp Ala Asp
                  85                  90                  95    
 Gly Ala Phe Thr Cys Cys Thr Asn Asp Lys Ala Thr Gln Thr Pro Leu
             100                 105                 110        
 Ser Trp Gln Glu Leu Glu Gly Glu Arg Ala Ser Ser Cys Ala His Lys
         115                 120                 125            
 Arg Ser Ala Ser Trp Gly Ser Thr Asp His Arg Lys Glu Ile Ser Lys
     130                 135                 140                
 Leu Lys Gln Gln Leu Gln Arg Thr Lys Leu Ser Arg Ser Gly Lys Glu
 145                 150                 155                 160
 Lys Glu Arg Gly Ser Pro Leu Leu Gly Asp His Ala Val Arg Gly Ala
                 165                 170                 175    
 Leu Arg Ala Ser Pro Pro Ser Phe Pro Ser Gly Ser Pro Val Leu Arg
             180                 185                 190        
 Leu Ser Pro Cys Leu His Arg Ser Leu Glu Gly Leu Asn Gln Glu Leu
         195                 200                 205            
 Glu Glu Val Phe Val Lys Glu Gln Gly Glu Glu Glu Leu Leu Arg Ile
     210                 215                 220                
 Leu Asp Ile Pro Asp Gly His Arg Ala Pro Ala Pro Pro Gln Ser Gly
 225                 230                 235                 240
 Ser Cys Asp His Pro Leu Leu Leu Leu Glu Pro Gly Asn Leu Ala Ser
                 245                 250                 255    
 Ser Pro Ser Met Ser Leu Ala Ser Pro Gln Pro Cys Gly Leu Ala Ser
             260                 265                 270        
 His Glu Glu His Arg Gly Ala Ala Glu Glu Leu Ala Ser Thr Pro Asn
         275                 280                 285            
 Asp Lys Ala Ser Ser Pro Gly His Pro Ala Phe Leu Glu Asp Gly Ser
     290                 295                 300                
 Pro Ser Pro Val Leu Ala Phe Ala Ala Ser Pro Arg Pro Asn His Ser
 305                 310                 315                 320
 Tyr Ile Phe Lys Arg Glu Pro Pro Glu Gly Cys Glu Lys Val Arg Val
                 325                 330                 335    
 Phe Glu Glu Ala Thr Ser Pro Gly Pro Asp Leu Ala Phe Leu Thr Ser
             340                 345                 350        
 Cys Pro Asp Lys Asn Lys Val His Phe Asn Pro Thr Gly Ser Ala Phe
         355                 360                 365            
 Cys Pro Val Asn Leu Met Lys Pro Leu Phe Pro Gly Met Gly Phe Ile
     370                 375                 380                
 Phe Arg Asn Cys Pro Ser Asn Pro Gly Ser Pro Leu Pro Pro Ala Ser
 385                 390                 395                 400
 Pro Arg Pro Pro Pro Arg Lys Asp Pro Glu Ala Ser Lys Ala Ser Pro
                 405                 410                 415    
 Leu Pro Phe Glu Pro Trp Gln Arg Thr Pro Pro Ser Glu Glu Pro Val
             420                 425                 430        
 Leu Phe Gln Ser Ser Leu Met Val
         435                 440



      <210> 552
      <211> 1183
      <212> PRT
      <213> Homo sapiens


      <400> 552
 Met Tyr Glu Arg Glu Leu Glu Gln Leu Arg Gln Gln Leu Ser Pro Asp
   1               5                  10                  15    
 Arg Gln Pro Gln Ser Ser Gly Pro Asp Arg Leu Ala Tyr Ser Ser Gln
              20                  25                  30        
 Thr Ala Gln Gln Lys Val Thr Gln Trp Ala Glu Glu Arg Asp Glu Leu
          35                  40                  45            
 Phe Arg Gln Ser Leu Ala Lys Leu Arg Glu Gln Leu Val Lys Ala Asn
      50                  55                  60                
 Thr Leu Val Arg Glu Ala Asn Phe Leu Ala Glu Glu Met Ser Lys Leu
  65                  70                  75                  80
 Thr Asp Tyr Gln Val Thr Leu Gln Ile Pro Ala Ala Asn Leu Ser Ala
                  85                  90                  95    
 Asn Arg Lys Arg Gly Ala Ile Val Ser Glu Pro Ala Ile Gln Val Arg
             100                 105                 110        
 Arg Lys Gly Lys Ser Thr Gln Val Trp Thr Ile Glu Lys Leu Glu Asn
         115                 120                 125            
 Lys Leu Ile Asp Met Arg Asp Leu Tyr Gln Glu Trp Lys Glu Lys Val
     130                 135                 140                
 Pro Glu Ala Lys Arg Leu Tyr Gly Lys Arg Gly Asp Pro Phe Tyr Glu
 145                 150                 155                 160
 Ala Gln Glu Asn His Asn Leu Ile Gly Val Ala Asn Val Phe Leu Glu
                 165                 170                 175    
 Cys Leu Phe Cys Asp Val Lys Leu Gln Tyr Ala Val Pro Ile Ile Ser
             180                 185                 190        
 Gln Gln Gly Glu Val Ala Gly Arg Leu His Val Glu Val Met Arg Val
         195                 200                 205            
 Thr Gly Ala Val Pro Glu Arg Val Val Glu Asp Asp Ser Ser Glu Asn
     210                 215                 220                
 Ser Ser Glu Ser Gly Ser Leu Glu Val Val Asp Ser Ser Gly Glu Ile
 225                 230                 235                 240
 Ile His Arg Val Lys Lys Leu Thr Cys Arg Val Lys Ile Lys Glu Ala
                 245                 250                 255    
 Thr Gly Leu Pro Leu Asn Leu Ser Asn Phe Val Phe Cys Gln Tyr Thr
             260                 265                 270        
 Phe Trp Asp Gln Cys Glu Ser Thr Val Ala Ala Pro Val Val Asp Pro
         275                 280                 285            
 Glu Val Pro Ser Pro Gln Ser Lys Asp Ala Gln Tyr Thr Val Thr Phe
     290                 295                 300                
 Ser His Cys Lys Asp Tyr Val Val Asn Val Thr Glu Glu Phe Leu Glu
 305                 310                 315                 320
 Phe Ile Ser Asp Gly Ala Leu Ala Ile Glu Val Trp Gly His Arg Cys
                 325                 330                 335    
 Ala Gly Asn Gly Ser Ser Ile Trp Glu Val Asp Ser Leu His Ala Lys
             340                 345                 350        
 Thr Arg Thr Leu His Asp Arg Trp Asn Glu Val Thr Arg Arg Ile Glu
         355                 360                 365            
 Met Trp Ile Ser Ile Leu Glu Leu Asn Glu Leu Gly Glu Tyr Ala Ala
     370                 375                 380                
 Val Glu Leu His Gln Ala Lys Asp Val Asn Thr Gly Gly Ile Phe Gln
 385                 390                 395                 400
 Leu Arg Gln Gly His Ser Arg Arg Val Gln Val Thr Val Lys Pro Val
                 405                 410                 415    
 Gln His Ser Gly Thr Leu Pro Leu Met Val Glu Ala Ile Leu Ser Val
             420                 425                 430        
 Ser Ile Gly Cys Val Thr Ala Arg Ser Thr Lys Leu Gln Arg Gly Leu
         435                 440                 445            
 Asp Ser Tyr Gln Arg Asp Asp Glu Asp Gly Asp Asp Met Asp Ser Tyr
     450                 455                 460                
 Gln Glu Glu Asp Leu Asn Cys Val Arg Glu Arg Trp Ser Asp Ala Leu
 465                 470                 475                 480
 Ile Lys Arg Arg Glu Tyr Leu Asp Glu Gln Ile Lys Lys Val Ser Asn
                 485                 490                 495    
 Lys Thr Glu Lys Thr Glu Asp Asp Val Glu Arg Glu Ala Gln Leu Val
             500                 505                 510        
 Glu Gln Trp Val Gly Leu Thr Glu Glu Arg Asn Ala Val Leu Val Pro
         515                 520                 525            
 Ala Pro Gly Gly Gly Ile Pro Gly Ala Pro Ala Asp Trp Ile Pro Pro
     530                 535                 540                
 Pro Gly Met Glu Thr His Ile Pro Val Leu Phe Leu Asp Leu Asn Ala
 545                 550                 555                 560
 Asp Asp Leu Ser Ala Asn Glu Gln Leu Val Gly Pro His Ala Ser Gly
                 565                 570                 575    
 Val Asn Ser Ile Leu Pro Lys Glu His Gly Ser Gln Phe Phe Tyr Leu
             580                 585                 590        
 Pro Ile Ile Lys His Ser Asp Asp Glu Val Ser Ala Thr Ala Ser Trp
         595                 600                 605            
 Asp Ser Ser Val His Asp Ser Val His Leu Asn Arg Val Thr Pro Gln
     610                 615                 620                
 Asn Glu Arg Ile Tyr Leu Ile Val Lys Thr Thr Val Gln Leu Ser His
 625                 630                 635                 640
 Pro Ala Ala Met Glu Leu Val Leu Arg Lys Arg Ile Ala Ala Asn Ile
                 645                 650                 655    
 Tyr Asn Lys Gln Ser Phe Thr Gln Ser Leu Lys Arg Arg Ile Ser Leu
             660                 665                 670        
 Lys Asn Ile Phe Tyr Ser Cys Gly Val Thr Tyr Glu Ile Val Ser Asn
         675                 680                 685            
 Ile Pro Lys Ala Thr Glu Glu Ile Glu Asp Arg Glu Thr Leu Ala Leu
     690                 695                 700                
 Leu Ala Ala Arg Ser Glu Asn Glu Gly Thr Ser Asp Gly Glu Thr Tyr
 705                 710                 715                 720
 Ile Glu Lys Tyr Thr Arg Gly Val Leu Gln Val Glu Asn Ile Leu Ser
                 725                 730                 735    
 Leu Glu Arg Leu Arg Gln Ala Val Thr Val Lys Glu Ala Leu Ser Thr
             740                 745                 750        
 Lys Ala Arg His Ile Arg Arg Ser Leu Ser Thr Pro Asn Val His Asn
         755                 760                 765            
 Val Ser Ser Ser Arg Pro Asp Leu Ser Gly Phe Asp Glu Asp Asp Lys
     770                 775                 780                
 Gly Trp Pro Glu Asn Gln Leu Asp Met Ser Asp Tyr Ser Ser Ser Tyr
 785                 790                 795                 800
 Gln Asp Val Ala Cys Tyr Gly Thr Leu Pro Arg Asp Ser Pro Arg Arg
                 805                 810                 815    
 Asn Lys Glu Gly Cys Thr Ser Glu Thr Pro His Ala Leu Thr Val Ser
             820                 825                 830        
 Pro Phe Lys Ala Phe Ser Pro Gln Pro Pro Lys Phe Phe Lys Pro Leu
         835                 840                 845            
 Met Pro Val Lys Glu Glu His Lys Lys Arg Ile Ala Leu Glu Ala Arg
     850                 855                 860                
 Pro Leu Leu Ser Gln Glu Ser Met Pro Pro Pro Gln Ala His Asn Pro
 865                 870                 875                 880
 Gly Cys Ile Val Pro Ser Gly Ser Asn Gly Ser Ser Met Pro Val Glu
                 885                 890                 895    
 His Asn Ser Lys Arg Glu Lys Lys Ile Asp Ser Glu Glu Glu Glu Asn
             900                 905                 910        
 Glu Leu Glu Ala Ile Asn Arg Lys Leu Ile Ser Ser Gln Pro Tyr Val
         915                 920                 925            
 Pro Val Glu Phe Ala Asp Phe Ser Val Tyr Asn Ala Ser Leu Glu Asn
     930                 935                 940                
 Arg Glu Trp Phe Ser Ser Lys Val Asp Leu Ser Asn Ser Arg Val Leu
 945                 950                 955                 960
 Glu Lys Glu Val Ser Arg Ser Pro Thr Thr Ser Ser Ile Thr Ser Gly
                 965                 970                 975    
 Tyr Phe Ser His Ser Ala Ser Asn Ala Thr Leu Ser Asp Met Val Val
             980                 985                 990        
 Pro Ser Ser Asp Ser Ser Asp Gln Leu Ala Ile Gln Thr Lys Asp Ala
         995                1000                1005            
 Asp Ser Thr Glu His Ser Thr Pro Ser Leu Val His Asp Phe Arg Pro
    1010                1015                1020                
 Ser Ser Asn Lys Glu Leu Thr Glu Val Glu Lys Gly Leu Val Lys Asp
1025                1030                1035                1040
 Lys Ile Ile Val Val Pro Leu Lys Glu Asn Ser Ala Leu Ala Lys Gly
                1045                1050                1055    
 Ser Pro Ser Ser Gln Ser Ile Pro Glu Lys Asn Ser Lys Ser Leu Cys
            1060                1065                1070        
 Arg Thr Gly Ser Cys Ser Glu Leu Asp Ala Cys Pro Ser Lys Ile Ser
        1075                1080                1085            
 Gln Pro Ala Arg Gly Phe Cys Pro Arg Glu Val Thr Val Glu His Thr
    1090                1095                1100                
 Thr Asn Ile Leu Glu Asp His Ser Phe Thr Glu Phe Met Gly Val Ser
1105                1110                1115                1120
 Glu Gly Lys Asp Phe Asp Gly Leu Thr Asp Ser Ser Ala Gly Glu Leu
                1125                1130                1135    
 Ser Ser Arg Arg Ser Leu Pro Asn Lys Thr Gly Gly Lys Thr Val Ser
            1140                1145                1150        
 Asp Gly Leu His His Pro Ser Gln Leu His Ser Lys Leu Glu Asn Asp
        1155                1160                1165            
 Gln Val Ile Ile Pro Glu Ala Ala Phe Trp Val Leu Cys Cys Gln
    1170                1175                1180            



      <210> 553
      <211> 274
      <212> PRT
      <213> Homo sapiens


      <400> 553
 Met Thr Thr Ser Arg Lys Arg Ser Arg Pro Ala Gln Leu His Pro Gly
   1               5                  10                  15    
 Leu Arg Arg Arg Arg Thr Ser Arg Ile Met Ala Lys Ser Gly Leu Arg
              20                  25                  30        
 Gln Asp Pro Gln Ser Thr Ala Ala Ala Thr Val Leu Lys Arg Ala Val
          35                  40                  45            
 Glu Leu Asp Ser Glu Ser Arg Tyr Pro Gln Ala Leu Val Cys Tyr Gln
      50                  55                  60                
 Glu Gly Ile Asp Leu Leu Leu Gln Val Leu Lys Gly Thr Lys Asp Asn
  65                  70                  75                  80
 Thr Lys Arg Cys Asn Leu Arg Glu Lys Ile Ser Lys Tyr Met Asp Arg
                  85                  90                  95    
 Ala Glu Asn Ile Lys Lys Tyr Leu Asp Gln Glu Lys Glu Asp Gly Lys
             100                 105                 110        
 Tyr His Lys Gln Ile Lys Ile Glu Glu Asn Ala Thr Gly Phe Ser Tyr
         115                 120                 125            
 Glu Ser Leu Phe Arg Glu Tyr Leu Asn Glu Thr Val Thr Glu Val Trp
     130                 135                 140                
 Ile Glu Asp Pro Tyr Ile Arg His Thr His Gln Leu Tyr Asn Phe Leu
 145                 150                 155                 160
 Arg Phe Cys Glu Met Leu Ile Lys Arg Pro Cys Lys Val Lys Thr Ile
                 165                 170                 175    
 His Leu Leu Thr Ser Leu Asp Glu Gly Ile Glu Gln Val Gln Gln Ser
             180                 185                 190        
 Arg Gly Leu Gln Glu Ile Glu Glu Ser Leu Arg Ser His Gly Val Leu
         195                 200                 205            
 Leu Glu Val Gln Tyr Ser Ser Ser Ile His Asp Arg Glu Ile Arg Phe
     210                 215                 220                
 Asn Asn Gly Trp Met Ile Lys Ile Gly Arg Gly Leu Asp Tyr Phe Lys
 225                 230                 235                 240
 Lys Pro Gln Ser Arg Phe Ser Leu Gly Tyr Cys Asp Phe Asp Leu Arg
                 245                 250                 255    
 Pro Cys His Glu Thr Thr Val Asp Ile Phe His Lys Lys His Thr Lys
             260                 265                 270        
 Asn Ile
        



      <210> 554
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 554
 Met Ala Ala Val Ala Ala Thr Ala Ala Ala Lys Gly Asn Gly Gly Gly
   1               5                  10                  15    
 Gly Gly Arg Ala Gly Ala Gly Asp Ala Ser Gly Thr Arg Lys Lys Lys
              20                  25                  30        
 Gly Pro Gly Pro Leu Ala Thr Ala Tyr Leu Val Ile Tyr Asn Val Val
          35                  40                  45            
 Met Thr Ala Gly Trp Leu Val Ile Ala Val Gly Leu Val Arg Ala Tyr
      50                  55                  60                
 Leu Ala Lys Gly Ser Tyr His Ser Leu Tyr Tyr Ser Ile Glu Lys Pro
  65                  70                  75                  80
 Leu Lys Phe Phe Gln Thr Gly Ala Leu Leu Glu Ile Leu His Cys Ala
                  85                  90                  95    
 Ile Gly Ile Val Pro Ser Ser Val Val Leu Thr Ser Phe Gln Val Met
             100                 105                 110        
 Ser Arg Val Phe Leu Ile Trp Ala Val Thr His Ser Val Lys Glu Val
         115                 120                 125            
 Gln Ser Glu Asp Ser Val Leu Leu Phe Val Ile Ala Trp Thr Ile Thr
     130                 135                 140                
 Glu Ile Ile Arg Tyr Ser Phe Tyr Thr Phe Ser Leu Leu Asn His Leu
 145                 150                 155                 160
 Pro Tyr Leu Ile Lys Trp Ala Arg Tyr Thr Leu Phe Ile Val Leu Tyr
                 165                 170                 175    
 Pro Met Gly Val Ser Gly Glu Leu Leu Thr Ile Tyr Ala Ala Leu Pro
             180                 185                 190        
 Phe Val Arg Gln Ala Gly Leu Tyr Ser Ile Ser Leu Pro Asn Lys Tyr
         195                 200                 205            
 Asn Phe Ser Phe Asp Tyr Tyr Ala Phe Leu Ile Leu Ile Met Ile Ser
     210                 215                 220                
 Tyr Ile Pro Ile Phe Pro Gln Leu Tyr Phe His Met Ile His Gln Arg
 225                 230                 235                 240
 Arg Lys Ile Leu Ser His Thr Glu Glu His Lys Lys Phe Glu
                 245                 250                



      <210> 555
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 555
 Met Ser Glu Lys Glu Asn Asn Phe Pro Pro Leu Pro Lys Phe Ile Pro
   1               5                  10                  15    
 Val Lys Pro Cys Phe Tyr Gln Asn Phe Ser Asp Glu Ile Pro Val Glu
              20                  25                  30        
 His Gln Val Leu Val Lys Arg Ile Tyr Arg Leu Trp Met Phe Tyr Cys
          35                  40                  45            
 Ala Thr Leu Gly Val Asn Leu Ile Ala Cys Leu Ala Trp Trp Ile Gly
      50                  55                  60                
 Gly Gly Ser Gly Thr Asn Phe Gly Leu Ala Phe Val Trp Leu Leu Leu
  65                  70                  75                  80
 Phe Thr Pro Cys Gly Tyr Val Cys Trp Phe Arg Pro Val Tyr Lys Ala
                  85                  90                  95    
 Phe Arg Ala Asp Ser Ser Phe Asn Phe Met Ala Phe Phe Phe Ile Phe
             100                 105                 110        
 Gly Ala Gln Phe Val Leu Thr Val Ile Gln Ala Ile Gly Phe Ser Gly
         115                 120                 125            
 Trp Gly Ala Cys Gly Trp Leu Ser Ala Ile Gly Phe Phe Gln Tyr Ser
     130                 135                 140                
 Pro Gly Ala Ala Val Val Met Leu Leu Pro Ala Ile Met Phe Ser Val
 145                 150                 155                 160
 Ser Ala Ala Met Met Ala Ile Ala Ile Met Lys Val His Arg Ile Tyr
                 165                 170                 175    
 Arg Gly Ala Gly Gly Ser Phe Gln Lys Ala Gln Thr Glu Trp Asn Thr
             180                 185                 190        
 Gly Thr Trp Arg Asn Pro Pro Ser Arg Glu Ala Gln Tyr Asn Asn Phe
         195                 200                 205            
 Ser Gly Asn Ser Leu Pro Glu Tyr Pro Thr Val Pro Ser Tyr Pro Gly
     210                 215                 220                
 Ser Gly Gln Trp Pro
 225                



      <210> 556
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 556
 Met Lys Ile Ser Glu Thr Lys Glu Lys Thr Lys Asn Thr His Gln Ala
   1               5                  10                  15    
 Asp Pro Pro Thr Trp Gly Gln Ile Arg Lys Leu Ala Gln Met Ala Glu
              20                  25                  30        
 Asp Asn Leu Arg Ala Gln Asn Lys Ser Lys Thr Thr Ser Asn Leu Met
          35                  40                  45            
 Val Ala Met Met Val Val Leu Thr Val Ala Val Ser Leu Pro Thr Val
      50                  55                  60                
 Lys Ala Thr Gln Asn Phe Thr Tyr Trp Thr Tyr Val Pro Phe Pro Pro
  65                  70                  75                  80
 Leu Ile Arg Ser Val Ser Trp Met Asp Pro Ile Ile Glu Val Tyr Asn
                  85                  90                  95    
 Asn Asp Arg Thr Ser Met Pro Glu Pro Ile Asp Asn Arg Val Pro Met
             100                 105                 110        
 His Pro Asn Glu Glu Gly Met Lys Met Asn Ile Ser Ile Gly Tyr Lys
         115                 120                 125            
 Tyr Pro Pro Ile Cys Leu Gly Pro Ala Ala Gly Cys Leu Gln Ile Gly
     130                 135                 140                
 Thr Gln Val Trp Leu Ala Val Ile Pro Gly Lys Asn Lys Ser Gln Ala
 145                 150                 155                 160
 Thr Leu Tyr Met Ile Ser Gly Gln Ser Leu Lys Tyr Asn His Ser Ser
                 165                 170                 175    
 Pro Glu Thr Gln Gln Phe
             180        



      <210> 557
      <211> 224
      <212> PRT
      <213> Homo sapiens


      <400> 557
 Met Val Glu Asp Glu Leu Ala Leu Phe Asp Lys Ser Ile Asn Glu Phe
   1               5                  10                  15    
 Trp Asn Lys Phe Lys Ser Thr Asp Thr Ser Cys Gln Met Ala Gly Leu
              20                  25                  30        
 Arg Asp Thr Tyr Lys Asp Ser Ile Lys Ala Phe Ala Glu Lys Leu Ser
          35                  40                  45            
 Val Lys Leu Lys Glu Glu Glu Arg Met Val Glu Met Phe Leu Glu Tyr
      50                  55                  60                
 Gln Asn Gln Ile Ser Arg Gln Asn Lys Leu Ile Gln Glu Lys Lys Asp
  65                  70                  75                  80
 Asn Leu Leu Lys Leu Ile Ala Glu Val Lys Gly Lys Lys Gln Glu Leu
                  85                  90                  95    
 Glu Val Leu Thr Ala Asn Ile Gln Asp Leu Lys Glu Glu Tyr Ser Arg
             100                 105                 110        
 Lys Lys Glu Thr Ile Ser Thr Ala Asn Lys Ala Asn Ala Glu Arg Leu
         115                 120                 125            
 Lys Arg Leu Gln Lys Ser Ala Asp Leu Tyr Lys Asp Arg Leu Gly Leu
     130                 135                 140                
 Glu Ile Arg Lys Ile Tyr Gly Glu Lys Leu Gln Phe Ile Phe Thr Asn
 145                 150                 155                 160
 Ile Asp Pro Lys Asn Pro Glu Ser Pro Phe Met Phe Ser Leu His Leu
                 165                 170                 175    
 Asn Glu Ala Arg Asp Tyr Glu Val Ser Asp Ser Ala Pro His Leu Glu
             180                 185                 190        
 Gly Leu Ala Glu Phe Gln Glu Asn Val Arg Lys Thr Asn Asn Phe Ser
         195                 200                 205            
 Ala Phe Leu Ala Asn Val Arg Lys Ala Phe Thr Ala Thr Val Tyr Asn
     210                 215                 220                





      <210> 558
      <211> 296
      <212> PRT
      <213> Homo sapiens


      <400> 558
 Met Asn Arg Trp Tyr Val Lys Pro Leu Glu Thr Ser Ser Ser Lys Val
   1               5                  10                  15    
 Lys Ala Lys Thr Ile Val Met Ile Pro Asp Ser Gln Lys Leu Leu Arg
              20                  25                  30        
 Cys Glu Leu Glu Ser Leu Lys Ser Gln Leu Gln Ala Gln Thr Lys Ala
          35                  40                  45            
 Phe Glu Phe Leu Asn His Ser Val Thr Met Leu Glu Lys Glu Ser Cys
      50                  55                  60                
 Leu Gln Gln Ile Lys Ile Gln Gln Leu Glu Glu Val Leu Ser Pro Thr
  65                  70                  75                  80
 Gly Arg Gln Gly Glu Lys Glu Glu His Lys Trp Gly Met Glu Gln Gly
                  85                  90                  95    
 Arg Gln Glu Leu Tyr Gly Ala Leu Thr Gln Gly Leu Gln Gly Leu Glu
             100                 105                 110        
 Lys Thr Leu Arg Asp Ser Glu Glu Met Gln Arg Ala Arg Thr Thr Arg
         115                 120                 125            
 Cys Leu Gln Leu Leu Ala Gln Glu Ile Arg Asp Ser Lys Lys Phe Leu
     130                 135                 140                
 Trp Glu Glu Leu Glu Leu Val Arg Glu Glu Val Thr Phe Ile Tyr Gln
 145                 150                 155                 160
 Lys Leu Gln Ala Gln Glu Asp Glu Ile Ser Glu Asn Leu Val Asn Ile
                 165                 170                 175    
 Gln Lys Met Gln Lys Thr Gln Val Lys Cys Arg Lys Ile Leu Thr Lys
             180                 185                 190        
 Met Lys Gln Gln Gly His Glu Thr Ala Ala Cys Pro Glu Thr Glu Glu
         195                 200                 205            
 Ile Pro Gln Gly Ala Ser Gly Cys Trp Lys Asp Asp Leu Gln Lys Glu
     210                 215                 220                
 Leu Ser Asp Ile Trp Ser Ala Val His Val Leu Gln Asn Ser Ile Asp
 225                 230                 235                 240
 Ser Leu Thr Leu Cys Ser Gly Ala Cys Pro Lys Ala Ser Ser Leu Arg
                 245                 250                 255    
 Gly His Lys Gly His Gln Cys Leu Ser Pro Pro Leu Pro Ser Trp Asp
             260                 265                 270        
 Ser Asp Ser Asp Ser Asp Gln Asp Leu Ser Gln Pro Pro Phe Ser Lys
         275                 280                 285            
 Ser Gly Arg Ser Phe Pro Pro Ala
     290                 295    



      <210> 559
      <211> 50
      <212> PRT
      <213> Homo sapiens


      <400> 559
 Met Arg Pro Thr Pro Ala Leu Pro Ser Gly Tyr Thr Asp Cys Thr Thr
   1               5                  10                  15    
 Leu Glu Gly Leu Leu Tyr His Leu Asn Gln Arg Leu Leu Phe Ser Ser
              20                  25                  30        
 Pro Thr Ser Ala Ile Phe Val Leu Ala Arg Pro Gly Ala Ala Leu Gly
          35                  40                  45            
 Gln Lys
      50



      <210> 560
      <211> 172
      <212> PRT
      <213> Homo sapiens


      <400> 560
 Met Leu Ala Ala Gly Val Gly Gly Gln Gly Glu Arg Leu Ala Gly Arg
   1               5                  10                  15    
 Arg Arg Lys Met Ala Val Glu Ser Arg Val Thr Gln Glu Glu Ile Lys
              20                  25                  30        
 Lys Glu Pro Glu Lys Pro Ile Asp Arg Glu Lys Thr Cys Pro Leu Leu
          35                  40                  45            
 Leu Arg Val Phe Thr Thr Asn Asn Gly Arg His His Arg Met Asp Glu
      50                  55                  60                
 Phe Ser Arg Gly Asn Val Pro Ser Ser Glu Leu Gln Ile Tyr Thr Trp
  65                  70                  75                  80
 Met Asp Ala Thr Leu Lys Glu Leu Thr Ser Leu Val Lys Glu Val Tyr
                  85                  90                  95    
 Pro Glu Ala Arg Lys Lys Gly Thr His Phe Asn Phe Ala Ile Val Phe
             100                 105                 110        
 Thr Asp Val Lys Arg Pro Gly Tyr Arg Val Lys Glu Ile Gly Ser Thr
         115                 120                 125            
 Met Ser Gly Arg Lys Gly Thr Asp Asp Ser Met Thr Leu Gln Ser Gln
     130                 135                 140                
 Lys Phe Gln Ile Gly Asp Tyr Leu Asp Ile Ala Ile Thr Pro Pro Asn
 145                 150                 155                 160
 Arg Ala Pro Pro Pro Ser Gly Arg Met Arg Pro Tyr
                 165                 170        



      <210> 561
      <211> 294
      <212> PRT
      <213> Homo sapiens


      <400> 561
 Met Gly Pro Asp Thr Gly Thr Ser Gly Arg Val Phe Ser Leu Pro Ser
   1               5                  10                  15    
 Glu Ser Val Ala Phe Thr Arg Val Gly Leu Arg Ala Pro Gln Thr Pro
              20                  25                  30        
 Glu Asp Pro Ala Pro Asn Gly Tyr Leu Ser Pro Leu Leu Ser Leu Pro
          35                  40                  45            
 His Ser Ser Pro Phe Ser Pro Gln Pro Leu Pro Leu Pro Ala Pro Arg
      50                  55                  60                
 Arg Val Arg Ala Pro Leu Ser Ala Arg Thr Pro Lys Pro Pro Pro Phe
  65                  70                  75                  80
 Leu Trp Glu Pro Leu Leu Pro Leu Arg Pro Pro Gly Val Phe Trp Pro
                  85                  90                  95    
 Asp Ser Ala Ala Ser Phe His Arg Pro Ser Leu Leu Leu Pro Pro Cys
             100                 105                 110        
 Gly Ser Val Ala Asn Ile Phe Lys Gly Leu Val Ile Leu Pro Glu Met
         115                 120                 125            
 Ser Leu Val Ile Arg Asn Leu Gln Arg Val Ile Pro Ile Arg Arg Ala
     130                 135                 140                
 Pro Leu Arg Ser Lys Ile Glu Ile Val Arg Arg Ile Leu Gly Val Gln
 145                 150                 155                 160
 Lys Phe Asp Leu Gly Ile Ile Cys Val Asp Asn Lys Asn Ile Gln His
                 165                 170                 175    
 Ile Asn Arg Ile Tyr Arg Asp Arg Asn Val Pro Thr Asp Val Leu Ser
             180                 185                 190        
 Phe Pro Phe His Glu His Leu Lys Ala Gly Glu Phe Pro Gln Pro Asp
         195                 200                 205            
 Phe Pro Asp Asp Tyr Asn Leu Gly Asp Ile Phe Leu Gly Val Glu Tyr
     210                 215                 220                
 Ile Phe His Gln Cys Lys Glu Asn Glu Asp Tyr Asn Asp Val Leu Thr
 225                 230                 235                 240
 Val Thr Ala Thr His Gly Leu Cys His Leu Leu Gly Phe Thr His Gly
                 245                 250                 255    
 Thr Glu Ala Glu Trp Gln Gln Met Phe Gln Lys Glu Lys Ala Val Leu
             260                 265                 270        
 Asp Glu Leu Gly Arg Arg Thr Gly Thr Arg Leu Gln Pro Leu Thr Arg
         275                 280                 285            
 Gly Leu Phe Gly Gly Ser
     290                



      <210> 562
      <211> 248
      <212> PRT
      <213> Homo sapiens


      <400> 562
 Met Gly Pro Asp Thr Gly Thr Ser Gly Arg Val Phe Ser Leu Pro Ser
   1               5                  10                  15    
 Glu Ser Val Ala Phe Thr Arg Val Gly Leu Arg Ala Pro Gln Thr Pro
              20                  25                  30        
 Glu Asp Pro Ala Pro Asn Gly Tyr Leu Ser Pro Leu Leu Ser Leu Pro
          35                  40                  45            
 His Ser Ser Pro Phe Ser Pro Gln Pro Leu Pro Leu Pro Ala Pro Arg
      50                  55                  60                
 Arg Val Arg Ala Pro Leu Ser Ala Arg Thr Pro Lys Pro Pro Pro Phe
  65                  70                  75                  80
 Leu Trp Glu Pro Leu Leu Pro Leu Arg Pro Pro Gly Val Phe Trp Pro
                  85                  90                  95    
 Asp Ser Ala Ala Ser Phe His Arg Pro Ser Leu Leu Leu Pro Pro Cys
             100                 105                 110        
 Gly Ser Val Ala Asn Ile Phe Lys Gly Leu Val Ile Leu Pro Glu Met
         115                 120                 125            
 Ser Leu Val Ile Arg Asn Leu Gln Arg Val Ile Pro Ile Arg Arg Ala
     130                 135                 140                
 Pro Leu Arg Ser Lys Ile Glu Ile Val Arg Arg Ile Leu Gly Val Gln
 145                 150                 155                 160
 Lys Phe Asp Leu Gly Ile Ile Cys Val Asp Asn Lys Asn Ile Gln His
                 165                 170                 175    
 Ile Asn Arg Ile Tyr Arg Asp Arg Asn Val Pro Thr Asp Val Leu Ser
             180                 185                 190        
 Phe Pro Phe His Glu His Leu Lys Ala Gly Glu Phe Pro Gln Pro Asp
         195                 200                 205            
 Phe Pro Asp Asp Tyr Asn Leu Gly Asp Ile Phe Leu Gly Val Glu Tyr
     210                 215                 220                
 Ile Phe His Gln Cys Lys Glu Asn Glu Asp Tyr Asn Asp Val Leu Thr
 225                 230                 235                 240
 Val Ser Gly Asp Ala Glu Ile Ile
                 245            



      <210> 563
      <211> 308
      <212> PRT
      <213> Homo sapiens


      <400> 563
 Met Gly Asn Thr Leu Gly Leu Ala Pro Met Gly Thr Leu Pro Arg Arg
   1               5                  10                  15    
 Ser Pro Arg Arg Glu Glu Pro Leu Pro Asn Pro Gly Ser Phe Asp Glu
              20                  25                  30        
 Leu His Arg Leu Cys Lys Asp Val Phe Pro Ala Gln Met Glu Gly Val
          35                  40                  45            
 Lys Leu Val Val Asn Lys Val Leu Ser Ser His Phe Gln Val Ala His
      50                  55                  60                
 Thr Ile His Met Ser Ala Leu Gly Leu Pro Gly Tyr His Leu His Ala
  65                  70                  75                  80
 Ala Tyr Ala Gly Asp Trp Gln Leu Ser Pro Thr Glu Val Phe Pro Thr
                  85                  90                  95    
 Val Val Gly Asp Met Asp Ser Ser Gly Ser Leu Asn Ala Gln Val Leu
             100                 105                 110        
 Leu Leu Leu Ala Glu Arg Leu Arg Ala Lys Ala Val Phe Gln Thr Gln
         115                 120                 125            
 Gln Ala Lys Phe Leu Thr Trp Gln Phe Asp Gly Glu Tyr Arg Gly Asp
     130                 135                 140                
 Asp Tyr Thr Ala Thr Leu Thr Leu Gly Asn Pro Asp Leu Ile Gly Glu
 145                 150                 155                 160
 Ser Val Ile Met Val Ala His Phe Leu Gln Ser Leu Thr His Arg Leu
                 165                 170                 175    
 Val Leu Gly Gly Glu Leu Val Tyr His Arg Arg Pro Gly Glu Glu Gly
             180                 185                 190        
 Ala Ile Leu Thr Leu Ala Gly Lys Tyr Ser Ala Val His Trp Val Ala
         195                 200                 205            
 Thr Leu Asn Val Gly Ser Gly Gly Ala His Ala Ser Tyr Tyr His Arg
     210                 215                 220                
 Ala Asn Glu Gln Val Gln Val Gly Val Glu Phe Glu Ala Asn Thr Arg
 225                 230                 235                 240
 Leu Gln Asp Thr Thr Phe Ser Phe Gly Tyr His Leu Thr Leu Pro Gln
                 245                 250                 255    
 Ala Asn Met Val Phe Arg Gly Leu Val Asp Ser Asn Trp Cys Val Gly
             260                 265                 270        
 Ala Val Leu Glu Lys Lys Met Pro Pro Leu Pro Val Thr Leu Ala Leu
         275                 280                 285            
 Gly Ala Phe Leu Asn His Trp Arg Asn Arg Phe His Cys Gly Phe Ser
     290                 295                 300                
 Ile Thr Val Gly
 305            



      <210> 564
      <211> 299
      <212> PRT
      <213> Homo sapiens


      <400> 564
 Met Ala Asp His Asn Pro Asp Ser Asp Ser Thr Pro Arg Thr Leu Leu
   1               5                  10                  15    
 Arg Arg Val Leu Asp Thr Ala Asp Pro Arg Thr Pro Arg Arg Pro Arg
              20                  25                  30        
 Ser Ala Arg Ala Gly Ala Arg Arg Ala Leu Leu Glu Thr Ala Ser Pro
          35                  40                  45            
 Arg Lys Leu Ser Gly Gln Thr Arg Thr Ile Ala Arg Gly Arg Ser His
      50                  55                  60                
 Gly Ala Arg Ser Val Gly Arg Ser Ala His Ile Gln Ala Ser Gly His
  65                  70                  75                  80
 Leu Glu Glu Gln Thr Pro Arg Thr Leu Leu Lys Asn Ile Leu Leu Thr
                  85                  90                  95    
 Ala Pro Glu Ser Ser Ile Leu Met Pro Glu Ser Val Val Lys Pro Val
             100                 105                 110        
 Pro Ala Pro Gln Ala Val Gln Pro Ser Arg Gln Glu Ser Ser Cys Gly
         115                 120                 125            
 Ser Leu Glu Leu Gln Leu Pro Glu Leu Glu Pro Pro Thr Thr Leu Ala
     130                 135                 140                
 Pro Gly Leu Leu Ala Pro Gly Arg Arg Lys Gln Arg Leu Arg Leu Ser
 145                 150                 155                 160
 Val Phe Gln Gln Gly Val Asp Gln Gly Leu Ser Leu Ser Gln Glu Pro
                 165                 170                 175    
 Gln Gly Asn Ala Asp Ala Ser Ser Leu Thr Arg Ser Leu Asn Leu Thr
             180                 185                 190        
 Phe Ala Thr Pro Leu Gln Pro Gln Ser Val Gln Arg Pro Gly Leu Ala
         195                 200                 205            
 Arg Arg Pro Pro Ala Arg Arg Ala Val Asp Val Gly Ala Phe Leu Arg
     210                 215                 220                
 Asp Leu Arg Asp Thr Ser Leu Ala Pro Pro Asn Ile Val Leu Glu Asp
 225                 230                 235                 240
 Thr Gln Pro Phe Ser Gln Pro Met Val Gly Ser Pro Asn Val Tyr His
                 245                 250                 255    
 Ser Leu Pro Cys Thr Pro His Thr Gly Ala Glu Asp Ala Glu Gln Ala
             260                 265                 270        
 Ala Gly Arg Lys Thr Gln Ser Ser Gly Pro Gly Leu Gln Lys Asn Ser
         275                 280                 285            
 Glu Cys Val Ala Leu Val Ala Trp Ser Gln Ile
     290                 295                



      <210> 565
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 565
 Met Leu Gly Ile Leu Ile Tyr Ile Gln Asn Ser Asp Tyr Glu Glu Ile
   1               5                  10                  15    
 Thr Ile Asp Pro Thr Cys Ser Trp Lys Pro Val Pro Val Lys Pro Asp
              20                  25                  30        
 Met His Ile Lys Glu Glu Pro Asp Gly Pro Ala Leu Lys Arg Cys Arg
          35                  40                  45            
 Thr Val Ser Pro Ala His Val Leu Met Pro Ser Val Met Glu Met Ile
      50                  55                  60                
 Ala Ala Leu Gly Pro Gly Ala Ala Pro Phe Ala Pro Leu Gln Pro Pro
  65                  70                  75                  80
 Ser Val Pro Ala Pro Ser Asp Tyr Pro Gly Gln Gly Ser Ser Phe Leu
                  85                  90                  95    
 Gly Pro Gly Thr Phe Pro Glu Ser Phe Pro Pro Thr Thr Pro Ser Thr
             100                 105                 110        
 Pro Thr Leu Ala Glu Phe Thr Pro Gly Pro Pro Pro Ile Ser Tyr Gln
         115                 120                 125            
 Ser Asp Ile Pro Ser Ser Leu Leu Thr Ser Glu Lys Ser Thr Ala Cys
     130                 135                 140                
 Leu Pro Ser Gln Met Ala Pro Ala Gly His Leu Asp Pro Thr His Asn
 145                 150                 155                 160
 Pro Gly Thr Pro Gly Leu His Thr Ser Asn Leu Gly Ala Pro Pro Gly
                 165                 170                 175    
 Pro Gln Leu His His Ser Asn Pro Pro Pro Ala Ser Arg Gln Ser Leu
             180                 185                 190        
 Gly Gln Ala Ser Leu Gly Pro Thr Gly Glu Leu Ala Phe Ser Pro Ala
         195                 200                 205            
 Thr Gly Val Met Gly Pro Pro Ser Met Ser Gly Ala Gly Glu Ala Pro
     210                 215                 220                
 Glu Pro Ala Leu Asp Leu Leu Pro Glu Leu Thr Asn Pro Asp Glu Leu
 225                 230                 235                 240
 Leu Ser Tyr Leu Gly Pro Pro Asp Leu Pro Thr Asn Asn Asn Asp Asp
                 245                 250                 255    
 Leu Leu Ser Leu Phe Glu Asn Asn
             260                



      <210> 566
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 566
 Met Leu Leu Glu Lys Thr Leu Ala Ser Ser His Cys Ser Ser Thr Val
   1               5                  10                  15    
 Pro Gly Thr Ala Leu Phe Ser Ser Phe Leu Asn Val Ser Ser Ile His
              20                  25                  30        
 Ile Leu Cys Ile Thr Val Val Leu Gly Cys Gly Glu Leu Gly Met Cys
          35                  40                  45            
 Val His Gly Glu Met Gly Cys Ser Gly Tyr Tyr Lys Thr Ala Lys Gly
      50                  55                  60                
 Gly Leu His Gly Thr Pro Leu Ser Asn Pro Gly His Ser Cys Leu Gly
  65                  70                  75                  80
 Asn Ala Asn His Pro Tyr Gly Arg Gly Thr Ile Ile Lys Ile Asp Pro
                  85                  90                  95    
 Val Thr Gly Met Val Ser Asn Leu Thr Asn Leu Met Ala Tyr Ile Gly
             100                 105                 110        
 Glu Ala Ile Val Lys Pro Leu Asp Ser Leu Asp Leu Asp Met Leu Tyr
         115                 120                 125            
 Cys Asp Asn Gly Leu Cys Val Thr Glu Asn Val Ala Val Ser Thr Gly
     130                 135                 140                
 Lys Asp Trp Gly Asn Phe Phe Leu Trp Ser Ser Leu
 145                 150                 155    



      <210> 567
      <211> 203
      <212> PRT
      <213> Homo sapiens


      <400> 567
 Met Ala Cys Gly Ala Thr Leu Lys Arg Thr Leu Asp Phe Asp Pro Leu
   1               5                  10                  15    
 Leu Ser Pro Ala Ser Pro Lys Arg Arg Arg Cys Ala Pro Leu Ser Ala
              20                  25                  30        
 Pro Thr Ser Ala Ala Ala Ser Pro Leu Ser Ala Ala Ala Ala Thr Ala
          35                  40                  45            
 Ala Ser Phe Ser Ala Ala Ala Ala Ser Pro Gln Lys Tyr Leu Arg Met
      50                  55                  60                
 Glu Pro Ser Pro Phe Gly Asp Val Ser Ser Arg Leu Thr Thr Glu Gln
  65                  70                  75                  80
 Ile Leu Tyr Asn Ile Lys Gln Glu Tyr Lys Arg Met Gln Lys Arg Arg
                  85                  90                  95    
 His Leu Glu Thr Ser Phe Gln Gln Thr Asp Pro Cys Cys Thr Ser Asp
             100                 105                 110        
 Ala Gln Pro His Ala Phe Leu Leu Ser Gly Pro Ala Ser Pro Gly Thr
         115                 120                 125            
 Ser Ser Ala Ala Ser Ser Pro Leu Lys Lys Glu Gln Pro Leu Phe Thr
     130                 135                 140                
 Leu Arg Gln Val Gly Met Ile Cys Glu Arg Leu Leu Lys Glu Arg Glu
 145                 150                 155                 160
 Glu Lys Val Arg Glu Glu Tyr Glu Glu Ile Leu Asn Thr Lys Leu Ala
                 165                 170                 175    
 Glu Gln Tyr Asp Ala Phe Val Lys Phe Thr His Asp Gln Ile Met Arg
             180                 185                 190        
 Arg Tyr Gly Glu Gln Pro Ala Ser Tyr Val Ser
         195                 200            



      <210> 568
      <211> 111
      <212> PRT
      <213> Homo sapiens


      <400> 568
 Met Glu Gln Leu Ala Arg Leu Val Ser Ser Gly Gln Gly Ser Gln Lys
   1               5                  10                  15    
 Gly Pro His Gly Leu Arg His His Ser Cys Ser Val Val Gly Pro Phe
              20                  25                  30        
 Ala Val Leu Phe Gly Gly Glu Thr Leu Thr Arg Ala Arg Asp Thr Ile
          35                  40                  45            
 Cys Asn Asp Leu Tyr Ile Tyr Asp Thr Arg Thr Ser Pro Pro Leu Trp
      50                  55                  60                
 Phe His Phe Pro Cys Ala Asp Arg Gly Met Lys Arg Met Gly His Arg
  65                  70                  75                  80
 Thr Cys Leu Trp Asn Asp Gln Leu Tyr Leu Val Gly Gly Phe Gly Glu
                  85                  90                  95    
 Asp Gly Arg Thr Ala Ser Pro Gln Val Cys Ile Leu Asp Phe Ile
             100                 105                 110    



      <210> 569
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 569
 Met Ser Pro Ser Ala Met Gly Gly Phe Leu Cys Val Gln Phe Thr Ala
   1               5                  10                  15    
 Val His Pro Asp Pro Arg Thr Glu Pro Val Gln Asp Lys Cys Pro Val
              20                  25                  30        
 Asn Thr Trp Glu Ala Met Gln Ala Ser Ser Gln Gln Leu Leu Gln Thr
          35                  40                  45            
 Asp Pro Arg Pro Lys Pro Phe Leu Leu Pro Pro Leu Pro Pro Leu Leu
      50                  55                  60                
 Leu Ile Ser Ala Gly Thr Glu Val Ser Ser Leu Val Phe Gln Lys Ser
  65                  70                  75                  80
 Pro Leu His Thr Gln Pro Glu Gly Ala Ile Lys Thr Ala Gly Gln Pro
                  85                  90                  95    
 Thr Ser Val His Ser Lys Val Leu Ser Lys Gly Ser Leu Leu Leu Gly
             100                 105                 110        
 Glu
    



      <210> 570
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 570
 Met Lys Thr Ala Ser Leu Thr Glu Glu Lys Leu Glu Cys Ser Leu Trp
   1               5                  10                  15    
 Cys Cys Leu Ser Asp Pro Ser Pro Arg Gly Leu Ala Ala Arg Cys Cys
              20                  25                  30        
 Val Leu Glu Gly Leu Ile Val Gln Ser Arg Arg Gln Glu Ser Ser Ser
          35                  40                  45            
 Ser Phe Ser Pro Ile Cys Phe Val Asp Ser Asp Glu Pro Asn Leu Thr
      50                  55                  60                
 Ser Val Leu Glu His Leu Glu Asp Thr Lys Asn Asn His Ser Val Lys
  65                  70                  75                  80
 Arg Glu Ala Lys Leu Phe Ser Leu Phe Leu Met Asn Ile Ile Phe Arg
                  85                  90                  95    
 Asn
    



      <210> 571
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 571
 Met Leu Leu Gln Ser Cys Ser Lys Glu Thr Thr Arg Ala Val Lys Ile
   1               5                  10                  15    
 Tyr Arg Gly Ser Thr Pro Val Trp Gly Arg Gln Gly Lys Arg Thr Lys
              20                  25                  30        
 Met Met Arg Met Thr Leu Arg Ser Leu Phe Arg Ala Asp Leu Lys Gln
          35                  40                  45            
 Pro Phe Gly His Ala Ile Ser Phe Val Glu His Ser Gly Leu Ser Ile
      50                  55                  60                
 Cys Leu Ser Val Tyr Val Ser Asp Tyr Leu Ser Ile Tyr Ile Phe Ser
  65                  70                  75                  80
 Phe Phe Thr Ala Thr Tyr Thr Phe Phe Ser Lys Phe Tyr
                  85                  90            



      <210> 572
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 572
 Met Lys Glu Ala Gly Gln Met Gln Asn Leu Glu Ser Ala Arg Ala Gly
   1               5                  10                  15    
 Arg Ser Val Ser Thr Gln Thr Gly Ser Met Thr Gly Gln Ile Pro Arg
              20                  25                  30        
 Leu Ser Lys Val Asn Leu Phe Thr Leu Leu Ser Leu Trp Met Glu Leu
          35                  40                  45            
 Phe Pro Ala Glu Ala Gln Arg Gln Lys Ser Gln Lys Asn Glu Glu Gly
      50                  55                  60                
 Lys His Gly Pro Leu Gly Asp Asn Glu Glu Arg Thr Arg Val Ser Thr
  65                  70                  75                  80
 Asp Lys Arg Gln Lys Thr Met Phe Cys Leu Phe Glu Asn Asp Cys Lys
                  85                  90                  95    
 Cys Trp Ser
            



      <210> 573
      <211> 232
      <212> PRT
      <213> Homo sapiens


      <400> 573
 Met Ala Gly Asp Val Gly Gly Arg Ser Cys Thr Asp Ser Glu Leu Leu
   1               5                  10                  15    
 Leu His Pro Glu Leu Leu Ser Gln Glu Phe Leu Leu Leu Thr Leu Glu
              20                  25                  30        
 Gln Lys Asn Ile Ala Val Glu Thr Asp Val Arg Val Asn Lys Asp Ser
          35                  40                  45            
 Leu Thr Asp Leu Tyr Val Gln His Ala Ile Pro Leu Pro Gln Arg Asp
      50                  55                  60                
 Leu Pro Lys Asn Arg Trp Gly Lys Met Met Glu Lys Lys Arg Glu Gln
  65                  70                  75                  80
 His Glu Ile Lys Asn Glu Thr Lys Arg Ser Ser Thr Val Asp Gly Leu
                  85                  90                  95    
 Arg Lys Arg Pro Leu Ile Val Phe Asp Gly Ser Ser Thr Ser Thr Ser
             100                 105                 110        
 Ile Lys Val Lys Lys Thr Glu Asn Gly Asp Asn Asp Arg Leu Lys Pro
         115                 120                 125            
 Pro Pro Gln Ala Ser Phe Thr Ser Asn Ala Phe Arg Lys Leu Ser Asn
     130                 135                 140                
 Ser Ser Ser Ser Val Ser Pro Leu Ile Leu Ser Ser Asn Leu Pro Val
 145                 150                 155                 160
 Asn Asn Lys Thr Glu His Asn Asn Asn Asp Ala Lys Gln Asn His Asp
                 165                 170                 175    
 Leu Thr His Arg Lys Ser Pro Ser Gly Pro Val Lys Ser Pro Pro Leu
             180                 185                 190        
 Ser Pro Val Gly Thr Thr Pro Val Lys Leu Lys Arg Ala Ala Pro Lys
         195                 200                 205            
 Glu Glu Ala Glu Ala Met Asn Asn Leu Lys Pro Pro Gln Ala Lys Arg
     210                 215                 220                
 Lys Ile Gln His Val Thr Trp Pro
 225                 230        



      <210> 574
      <211> 213
      <212> PRT
      <213> Homo sapiens


      <400> 574
 Met Ser Arg Val Leu Val Pro Cys His Val Lys Gly Ser Val Ala Leu
   1               5                  10                  15    
 Gln Val Gly Asp Val Arg Thr Ser Gln Gly Arg Pro Gly Val Leu Val
              20                  25                  30        
 Ile Asp Val Thr Phe Pro Ser Val Ala Pro Phe Glu Leu Gln Glu Ile
          35                  40                  45            
 Thr Phe Lys Asn Tyr Tyr Thr Ala Phe Leu Ser Ile Arg Val Arg Gln
      50                  55                  60                
 Tyr Thr Ser Ala His Thr Pro Ala Lys Trp Val Thr Cys Leu Arg Asp
  65                  70                  75                  80
 Tyr Cys Leu Met Pro Asp Pro His Ser Glu Glu Gly Ala Gln Glu Tyr
                  85                  90                  95    
 Val Ser Leu Phe Lys His Gln Met Leu Cys Asp Met Ala Arg Ile Ser
             100                 105                 110        
 Glu Leu Arg Leu Ile Leu Arg Gln Pro Ser Pro Leu Trp Leu Ser Phe
         115                 120                 125            
 Thr Val Glu Glu Leu Gln Ile Tyr Gln Gln Gly Pro Lys Ser Pro Ser
     130                 135                 140                
 Val Thr Phe Pro Lys Trp Leu Ser His Pro Val Pro Cys Glu Gln Pro
 145                 150                 155                 160
 Ala Leu Leu Arg Glu Gly Leu Pro Asp Pro Ser Arg Val Ser Ser Glu
                 165                 170                 175    
 Val Gln Gln Met Trp Ala Leu Thr Glu Met Ile Arg Ala Ser His Thr
             180                 185                 190        
 Ser Ala Arg Ile Gly Arg Phe Asp Val Asp Gly Cys Tyr Asp Leu Asn
         195                 200                 205            
 Leu Leu Ser Tyr Thr
     210            



      <210> 575
      <211> 260
      <212> PRT
      <213> Homo sapiens


      <400> 575
 Met Asn Asn Leu Asn Asp Pro Pro Asn Trp Asn Ile Arg Pro Asn Ser
   1               5                  10                  15    
 Arg Ala Asp Gly Gly Asp Gly Ser Arg Trp Asn Tyr Ala Leu Leu Val
              20                  25                  30        
 Pro Met Leu Gly Leu Ala Ala Phe Arg Trp Ile Trp Ser Arg Glu Ser
          35                  40                  45            
 Gln Lys Glu Val Glu Lys Glu Arg Glu Ala Tyr Arg Arg Arg Thr Ala
      50                  55                  60                
 Ala Phe Gln Gln Asp Leu Glu Ala Lys Tyr His Ala Met Ile Ser Glu
  65                  70                  75                  80
 Asn Arg Arg Ala Val Ala Gln Leu Ser Leu Glu Leu Glu Lys Glu Gln
                  85                  90                  95    
 Asn Arg Thr Ala Ser Tyr Arg Glu Ala Leu Ile Ser Gln Gly Arg Lys
             100                 105                 110        
 Leu Val Glu Glu Lys Lys Leu Leu Glu Gln Glu Arg Ala Gln Val Met
         115                 120                 125            
 Gln Glu Lys Arg Gln Val Gln Pro Leu Arg Ser Ala Tyr Leu Ser Cys
     130                 135                 140                
 Leu Gln Arg Glu Glu Asn Trp Gln Arg Arg Ala Arg Leu Leu Leu Lys
 145                 150                 155                 160
 Glu Phe Glu Ala Val Leu Thr Glu Arg Gln Asn Ile Tyr Cys Ser Leu
                 165                 170                 175    
 Phe Leu Pro Arg Ser Lys Arg Leu Glu Ile Glu Lys Ser Leu Leu Val
             180                 185                 190        
 Arg Ala Ser Val Asp Pro Val Ala Ala Asp Leu Glu Met Ala Ala Gly
         195                 200                 205            
 Leu Thr Asp Ile Phe Gln His Asp Thr Tyr Cys Gly Asp Val Trp Asn
     210                 215                 220                
 Thr Asn Lys Arg Gln Asn Gly Arg Leu Met Trp Leu Tyr Leu Lys Tyr
 225                 230                 235                 240
 Trp Glu Leu Val Val Glu Leu Lys Lys Phe Lys Arg Val Glu Glu Ala
                 245                 250                 255    
 Ile Leu Glu Lys
             260



      <210> 576
      <211> 95
      <212> PRT
      <213> Homo sapiens


      <400> 576
 Met Pro Arg Ser His Leu Gly Gly Gln Phe Pro Pro Glu His Glu Ala
   1               5                  10                  15    
 Cys Pro Thr Pro Pro Ser Pro Glu Ala Gly Arg Pro Gln Lys Pro Gln
              20                  25                  30        
 Ser Met Lys Ala Pro Cys Leu Pro Pro Arg Gln Lys Lys Asp Lys Leu
          35                  40                  45            
 His His Lys Leu Gln Arg Glu Ala Asn Trp Leu Leu Gly Ser Val Asn
      50                  55                  60                
 Arg Pro Lys Gly Glu Asn His Cys Pro Lys His Phe Gln Pro His Ser
  65                  70                  75                  80
 Ala Gly Thr Cys Asp Leu Gln Glu Ile Arg Arg Phe Thr Lys Cys
                  85                  90                  95



      <210> 577
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 577
 Met Asp Gln Leu Val Phe Lys Glu Thr Ile Trp Asn Asp Ala Phe Trp
   1               5                  10                  15    
 Gln Asn Pro Trp Asp Gln Gly Gly Leu Ala Val Ile Ile Leu Phe Ile
              20                  25                  30        
 Thr Ala Val Leu Leu Leu Ile Leu Phe Ala Ile Val Phe Gly Leu Leu
          35                  40                  45            
 Thr Ser Thr Glu Asn Thr Gln Cys Glu Ala Gly Glu Glu Glu
      50                  55                  60        



      <210> 578
      <211> 76
      <212> PRT
      <213> Homo sapiens


      <400> 578
 Met Gly Arg Asn Phe Leu Ser Gln Ser Leu Cys Trp Asn Ile Ile Asp
   1               5                  10                  15    
 Thr Tyr Leu Arg Val Tyr Leu Phe Trp Leu Ile Phe Gln Asn Lys Pro
              20                  25                  30        
 Phe Trp Cys Gln Gly Ala Val Thr Leu Leu Lys Ile Cys Trp Gln Leu
          35                  40                  45            
 Tyr Phe Tyr Lys Thr Phe Gln Gln Lys Arg Leu Leu Tyr Ala Leu Asn
      50                  55                  60                
 Ile Phe Ile Leu Phe Asn Ser Phe Ser Leu Arg Gly
  65                  70                  75    



      <210> 579
      <211> 293
      <212> PRT
      <213> Homo sapiens


      <400> 579
 Met Arg Val Asp Ser Ser Ala Asp Pro Thr Met Ser Gln Glu Gln Gly
   1               5                  10                  15    
 Pro Gly Ser Ser Thr Pro Pro Ser Ser Pro Thr Leu Leu Asp Ala Leu
              20                  25                  30        
 Leu Gln Asn Leu Tyr Asp Phe Gly Gly Thr Glu Gly Glu Thr Glu Gln
          35                  40                  45            
 Lys Lys Ile Ile Lys Lys Arg Glu Asn Lys Lys Arg Asp Val Met Ala
      50                  55                  60                
 Ser Ala Ala Leu Ala Ala Glu Pro Ser Pro Leu Pro Gly Ser Leu Ile
  65                  70                  75                  80
 Arg Gly Gln Arg Lys Ser Ala Ser Ser Phe Phe Lys Glu Leu Arg Glu
                  85                  90                  95    
 Glu Arg His Cys Ala Pro Ser Gly Thr Pro Thr Gly Pro Glu Ile Leu
             100                 105                 110        
 Ala Ala Ala Val Pro Pro Ser Ser Leu Lys Asn Asn Arg Glu Gln Val
         115                 120                 125            
 Glu Val Val Glu Phe His Ser Asn Lys Lys Arg Lys Leu Thr Pro Asp
     130                 135                 140                
 His Asn Lys Asn Thr Lys Gln Ala Asn Pro Ser Val Leu Glu Arg Asp
 145                 150                 155                 160
 Val Asp Thr Gln Glu Phe Asn Leu Glu Lys Ala Arg Leu Glu Val His
                 165                 170                 175    
 Arg Phe Gly Ile Thr Gly Tyr Gly Lys Gly Lys Glu Arg Ile Leu Glu
             180                 185                 190        
 Gln Glu Arg Ala Ile Met Leu Gly Ala Lys Pro Pro Lys Lys Ser Tyr
         195                 200                 205            
 Val Asn Tyr Lys Val Leu Gln Glu Gln Ile Lys Glu Lys Lys Ala Ala
     210                 215                 220                
 Lys Glu Glu Glu Lys Arg Leu Ala Gln Glu Thr Asp Ile Phe Lys Lys
 225                 230                 235                 240
 Lys Lys Arg Lys Gly Gln Glu Asp Arg Lys Ser Lys Lys Lys Ser Ala
                 245                 250                 255    
 Pro Ser Ile Leu Ser Asn Gly Arg Ile Gly Gln Val Gly Lys Phe Lys
             260                 265                 270        
 Asn Gly Thr Leu Ile Leu Ser Pro Val Asp Ile Lys Lys Ile Asn Ser
         275                 280                 285            
 Ser Arg Val Ala Lys
     290            



      <210> 580
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 580
 Met Trp Phe His Lys Gly Gly Arg Lys Gln His Phe Lys Val Thr Phe
   1               5                  10                  15    
 Trp Glu Thr Asp Leu Ser Asn Asn Lys Thr Leu Val Ser Leu Lys Lys
              20                  25                  30        
 Lys Lys Pro Phe His Leu Tyr Cys Val Ile Tyr Ile Pro Leu Val Pro
          35                  40                  45            
 Lys Leu Ile Ile Leu Phe Leu Asp Ile Ala Phe Ile Pro Lys Thr Leu
      50                  55                  60                
 Ile Ser Pro Cys Asn Tyr Ser Ile Phe Arg
  65                  70                



      <210> 581
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 581
 Met Thr Asp Asp Leu Glu Lys Pro Ile Ser Asp Cys Thr Leu Thr Gly
   1               5                  10                  15    
 Ile Leu Ser Leu Cys Leu Trp Thr Ser Asp Ala Val Cys Lys Met Lys
              20                  25                  30        
 Ile Arg Asp Trp Leu Ile Ser Phe Tyr Leu Thr Arg Cys Gln Ile Leu
          35                  40                  45            
 Lys Ser Val Phe Ser Lys Gln Phe Cys His Leu Ile Val Phe Thr Gly
      50                  55                  60                
 Ala Leu Val Gly Ser Phe Arg Arg Thr Ile Ser Val Pro Arg Ala
  65                  70                  75                



      <210> 582
      <211> 54
      <212> PRT
      <213> Homo sapiens


      <400> 582
 Met His Ser Gly Phe Tyr Thr Ser Ala Phe Arg Gly Leu Trp Gln His
   1               5                  10                  15    
 Gly Met Gly Gln Glu Val Leu Leu Leu His Leu Pro Leu Met Ser Val
              20                  25                  30        
 Thr His Pro Phe Cys Thr Ala Gly Val Val Asn Ala Phe Val Ser Ser
          35                  40                  45            
 Ser Ser His Ala Asp Cys
      50                



      <210> 583
      <211> 1196
      <212> PRT
      <213> Homo sapiens


      <400> 583
 Met Thr Glu Cys Thr Ser Leu Gln Phe Val Ser Pro Phe Ala Phe Glu
   1               5                  10                  15    
 Ala Met Gln Lys Val Asp Val Val Cys Leu Ala Ser Leu Ser Asp Pro
              20                  25                  30        
 Glu Leu Arg Leu Leu Leu Pro Cys Leu Val Arg Met Ala Leu Cys Ala
          35                  40                  45            
 Pro Ala Asp Gln Ser Gln Ser Trp Ala Gln Asp Lys Lys Leu Ile Leu
      50                  55                  60                
 Arg Leu Leu Ser Gly Val Glu Ala Val Asn Ser Ile Val Ala Leu Leu
  65                  70                  75                  80
 Ser Val Asp Phe His Ala Leu Glu Gln Asp Ala Ser Lys Glu Gln Gln
                  85                  90                  95    
 Leu Arg His Lys Leu Gly Gly Gly Ser Gly Glu Ser Ile Leu Val Ser
             100                 105                 110        
 Gln Leu Gln His Gly Leu Thr Leu Glu Phe Glu His Ser Asp Ser Pro
         115                 120                 125            
 Arg Arg Leu Arg Leu Val Leu Ser Glu Leu Leu Ala Ile Met Asn Lys
     130                 135                 140                
 Val Ser Glu Ser Asn Gly Glu Phe Phe Phe Lys Ser Ser Glu Leu Phe
 145                 150                 155                 160
 Glu Ser Pro Val Tyr Leu Glu Glu Ala Ala Asp Val Leu Cys Ile Leu
                 165                 170                 175    
 Gln Ala Glu Leu Pro Ser Leu Leu Pro Ile Val Asp Val Ala Glu Ala
             180                 185                 190        
 Leu Leu His Val Arg Asn Gly Ala Trp Phe Leu Cys Leu Leu Val Ala
         195                 200                 205            
 Asn Val Pro Asp Ser Phe Asn Glu Val Cys Arg Gly Leu Ile Lys Asn
     210                 215                 220                
 Gly Glu Arg Gln Asp Glu Glu Ser Leu Gly Gly Arg Arg Arg Thr Asp
 225                 230                 235                 240
 Ala Leu Arg Phe Leu Cys Lys Met Asn Pro Ser Gln Ala Leu Lys Val
                 245                 250                 255    
 Arg Gly Met Val Val Glu Glu Cys His Leu Pro Gly Leu Gly Val Ala
             260                 265                 270        
 Leu Thr Leu Asp His Thr Lys Asn Glu Ala Cys Glu Asp Gly Val Ser
         275                 280                 285            
 Asp Leu Val Cys Phe Val Ser Gly Leu Leu Leu Gly Thr Asn Ala Lys
     290                 295                 300                
 Val Arg Thr Trp Phe Gly Thr Phe Ile Arg Asn Gly Gln Gln Arg Lys
 305                 310                 315                 320
 Arg Glu Thr Ser Ser Ser Val Leu Trp Gln Met Arg Arg Gln Leu Leu
                 325                 330                 335    
 Leu Glu Leu Met Gly Ile Leu Pro Thr Val Arg Ser Thr Arg Ile Val
             340                 345                 350        
 Glu Glu Ala Asp Val Asp Met Glu Pro Asn Val Ser Val Tyr Ser Gly
         355                 360                 365            
 Leu Lys Glu Glu His Val Val Lys Ala Ser Ala Leu Leu Arg Leu Tyr
     370                 375                 380                
 Cys Ala Leu Met Gly Ile Ala Gly Leu Lys Pro Thr Glu Glu Glu Ala
 385                 390                 395                 400
 Glu Gln Leu Leu Gln Leu Met Thr Ser Arg Pro Pro Ala Thr Pro Ala
                 405                 410                 415    
 Gly Val Arg Phe Val Ser Leu Ser Phe Cys Met Leu Leu Ala Phe Ser
             420                 425                 430        
 Thr Leu Val Ser Thr Pro Glu Gln Glu Gln Leu Met Val Val Trp Leu
         435                 440                 445            
 Ser Trp Met Ile Lys Glu Glu Ala Tyr Phe Glu Ser Thr Ser Gly Val
     450                 455                 460                
 Ser Ala Ser Phe Gly Glu Met Leu Leu Leu Val Ala Met Tyr Phe His
 465                 470                 475                 480
 Ser Asn Gln Leu Ser Ala Ile Ile Asp Leu Val Cys Ser Thr Leu Gly
                 485                 490                 495    
 Met Lys Ile Val Ile Lys Pro Ser Ser Leu Ser Arg Met Lys Thr Ile
             500                 505                 510        
 Phe Thr Gln Glu Ile Phe Thr Glu Gln Val Val Thr Ala His Ala Val
         515                 520                 525            
 Arg Val Pro Val Thr Ser Asn Leu Ser Ala Asn Ile Thr Gly Phe Leu
     530                 535                 540                
 Pro Ile His Cys Ile Tyr Gln Leu Leu Arg Ser Arg Ser Phe Thr Lys
 545                 550                 555                 560
 His Lys Val Ser Ile Lys Asp Trp Ile Tyr Arg Gln Leu Cys Glu Thr
                 565                 570                 575    
 Ser Thr Pro Leu His Pro Gln Leu Leu Pro Leu Ile Asp Val Tyr Ile
             580                 585                 590        
 Asn Ser Ile Leu Thr Pro Ala Ser Lys Ser Asn Pro Glu Ala Thr Asn
         595                 600                 605            
 Gln Pro Val Thr Glu Gln Glu Ile Leu Asn Ile Phe Gln Gly Val Ile
     610                 615                 620                
 Gly Gly Asp Asn Ile Arg Leu Asn Gln Arg Phe Ser Ile Thr Ala Gln
 625                 630                 635                 640
 Leu Leu Val Leu Tyr Tyr Ile Leu Ser Tyr Glu Glu Ala Leu Leu Ala
                 645                 650                 655    
 Asn Thr Lys Thr Leu Ala Ala Met Gln Arg Lys Pro Lys Ser Tyr Ser
             660                 665                 670        
 Ser Ser Leu Met Asp Gln Ile Pro Ile Lys Phe Leu Ile Arg Gln Ala
         675                 680                 685            
 Gln Gly Leu Gln Gln Glu Leu Gly Gly Leu His Ser Ala Leu Leu Arg
     690                 695                 700                
 Leu Leu Ala Thr Asn Tyr Pro His Leu Cys Ile Val Asp Asp Trp Ile
 705                 710                 715                 720
 Cys Glu Glu Glu Ile Thr Gly Thr Asp Ala Leu Leu Arg Arg Met Leu
                 725                 730                 735    
 Leu Thr Asn Asn Ala Lys Asn His Ser Pro Lys Gln Leu Gln Glu Ala
             740                 745                 750        
 Phe Ser Ala Val Pro Val Asn His Thr Gln Val Met Gln Ile Ile Glu
         755                 760                 765            
 His Leu Thr Leu Leu Ser Ala Ser Glu Leu Ile Pro Tyr Ala Glu Val
     770                 775                 780                
 Leu Thr Ser Asn Met Ser Gln Leu Leu Asn Ser Gly Val Pro Arg Arg
 785                 790                 795                 800
 Ile Leu Gln Thr Val Asn Lys Leu Trp Met Val Leu Asn Thr Val Met
                 805                 810                 815    
 Pro Arg Arg Leu Trp Leu Met Thr Val Asn Ala Leu Gln Pro Ser Ile
             820                 825                 830        
 Lys Phe Val Arg Gln Gln Lys Tyr Thr Gln Asn Asp Leu Met Ile Asp
         835                 840                 845            
 Pro Leu Ile Val Leu Arg Cys Asp Gln Arg Val His Arg Cys Pro Pro
     850                 855                 860                
 Leu Met Asp Ile Thr Leu His Met Leu Asn Gly Tyr Leu Leu Ala Ser
 865                 870                 875                 880
 Lys Ala Tyr Leu Ser Ala His Leu Lys Glu Thr Glu Gln Asp Arg Pro
                 885                 890                 895    
 Ser Gln Asn Asn Thr Ile Gly Leu Val Gly Gln Thr Asp Ala Pro Glu
             900                 905                 910        
 Val Thr Arg Glu Glu Leu Lys Asn Ala Leu Leu Ala Ala Gln Asp Ser
         915                 920                 925            
 Ala Ala Val Gln Ile Leu Leu Glu Ile Cys Leu Pro Thr Glu Glu Glu
     930                 935                 940                
 Lys Ala Asn Gly Val Asn Pro Asp Ser Leu Leu Arg Asn Val Gln Ser
 945                 950                 955                 960
 Val Ile Thr Thr Ser Ala Pro Asn Lys Gly Met Glu Glu Gly Glu Asp
                 965                 970                 975    
 Asn Leu Leu Cys Asn Leu Arg Glu Val Gln Cys Leu Ile Cys Cys Leu
             980                 985                 990        
 Leu His Gln Met Tyr Ile Ala Asp Pro Asn Ile Ala Lys Leu Val His
         995                1000                1005            
 Phe Gln Gly Tyr Pro Cys Glu Leu Leu Pro Leu Thr Val Ala Gly Ile
    1010                1015                1020                
 Pro Ser Met His Ile Cys Leu Asp Phe Ile Pro Glu Leu Ile Ala Gln
1025                1030                1035                1040
 Pro Glu Leu Glu Lys Gln Ile Phe Ala Ile Gln Leu Leu Ser His Leu
                1045                1050                1055    
 Cys Ile Gln Tyr Ala Leu Pro Lys Ser Leu Ser Val Ala Arg Leu Ala
            1060                1065                1070        
 Val Asn Val Met Gly Thr Leu Leu Thr Val Leu Thr Gln Ala Lys Arg
        1075                1080                1085            
 Tyr Ala Phe Phe Met Pro Thr Leu Pro Ser Leu Val Ser Phe Cys Arg
    1090                1095                1100                
 Ala Phe Pro Pro Leu Tyr Glu Asp Ile Met Ser Leu Leu Ile Gln Ile
1105                1110                1115                1120
 Gly Gln Val Cys Ala Ser Asp Val Ala Thr Gln Thr Arg Asp Ile Asp
                1125                1130                1135    
 Pro Ile Ile Thr Arg Leu Gln Gln Ile Lys Glu Lys Pro Ser Gly Trp
            1140                1145                1150        
 Ser Gln Ile Cys Lys Asp Ser Ser Tyr Lys Asn Gly Ser Arg Asp Thr
        1155                1160                1165            
 Gly Ser Met Asp Pro Asp Val Gln Leu Cys His Cys Ile Glu Arg Thr
    1170                1175                1180                
 Val Ile Glu Ile Ile Asn Met Ser Val Ser Gly Ile
1185                1190                1195    



      <210> 584
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 584
 Met Gly Gly Cys Pro Val Arg Lys Arg Arg Arg Asn Gly Ser Lys Glu
   1               5                  10                  15    
 Gly Asn His His Ser Thr Gln Pro Lys Arg Asn Lys Arg Asn Pro Ile
              20                  25                  30        
 Phe Gln Asp Ser Gln Asp Thr Glu Phe Ser Trp Ser Asp Asn Glu Arg
          35                  40                  45            
 Ser Ser Ser Arg Ile Asn Ile Pro Glu Arg Ala Ser Gly Pro Glu Gly
      50                  55                  60                
 Asn Leu Asn Gln Ile Val Thr Glu Pro Asp Ala Asn Phe Pro Gln Phe
  65                  70                  75                  80
 Leu His Glu Gly Tyr Val Pro Cys Gln Gly Leu Tyr Ser His Ile Asn
                  85                  90                  95    
 Gln Thr Leu Lys Glu Ala His Phe Asn Ser Leu Gln Gln Arg Gly Gln
             100                 105                 110        
 Ala Pro Thr
         115



      <210> 585
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 585
 Met Gly Val Trp Glu Glu Glu Lys Ala Leu Ala Val Leu Leu Glu Val
   1               5                  10                  15    
 Gly Ile Lys Val Glu Lys Pro Glu Asn Ser Ser Pro Leu Leu Thr Cys
              20                  25                  30        
 Leu Glu Ile Arg Arg Lys Leu Lys Arg Arg Gly Glu Gly Ala Lys Arg
          35                  40                  45            
 Asp Lys Thr Gly Ser Ser Pro Tyr Lys Ile Glu Asn Ala Ile Leu Glu
      50                  55                  60                
 Glu Asn Ile Glu Glu Ala Pro Lys Lys Lys Asn Gln Ser Lys Leu Val
  65                  70                  75                  80
 Leu His Glu Thr Phe Pro Lys His Thr Phe Leu Met Asn Gly Leu Ile
                  85                  90                  95    
 Gln Gly Val Lys Gly Leu Leu Ser Phe Leu Ser Ala Pro Leu Ile Gly
             100                 105                 110        
 Ala Leu Ser Asp Val Trp Gly Arg Lys Ser Phe Leu Leu Leu Thr Val
         115                 120                 125            
 Phe Phe Thr Cys Ala Pro Ile Pro Leu Met Lys Ile Ser Pro Trp Trp
     130                 135                 140                
 Tyr Phe Ala Val Ile Ser Val Ser Gly Val Phe Ala Val Thr Phe Ser
 145                 150                 155                 160
 Val Val Phe Ala Tyr Val Ala Asp Ile Thr Gln Glu His Glu Arg Ser
                 165                 170                 175    
 Met Ala Tyr Gly Leu Val Cys Met Phe Ile Leu Tyr Leu Leu Tyr Leu
             180                 185                 190        
 Leu Arg Asn Ala Phe Phe Leu Arg
         195                 200



      <210> 586
      <211> 399
      <212> PRT
      <213> Homo sapiens


      <400> 586
 Met Ala Val Thr Met Leu Gln Asp Trp Cys Arg Trp Met Gly Val Asn
   1               5                  10                  15    
 Ala Arg Arg Gly Leu Leu Ile Leu Gly Ile Pro Glu Asp Cys Asp Asp
              20                  25                  30        
 Ala Glu Phe Gln Glu Ser Leu Glu Ala Ala Leu Arg Pro Met Gly His
          35                  40                  45            
 Phe Thr Val Leu Gly Lys Ala Phe Arg Glu Glu Asp Asn Ala Thr Ala
      50                  55                  60                
 Ala Leu Val Glu Leu Asp Arg Glu Val Asn Tyr Ala Leu Val Pro Arg
  65                  70                  75                  80
 Glu Ile Pro Gly Thr Gly Gly Pro Trp Asn Val Val Phe Val Pro Arg
                  85                  90                  95    
 Cys Ser Gly Glu Glu Phe Leu Gly Leu Gly Arg Val Phe His Phe Pro
             100                 105                 110        
 Glu Gln Glu Gly Gln Met Val Glu Ser Val Ala Gly Ala Leu Gly Val
         115                 120                 125            
 Gly Leu Arg Arg Val Cys Trp Leu Arg Ser Ile Gly Gln Ala Val Gln
     130                 135                 140                
 Pro Trp Val Glu Ala Val Arg Cys Gln Ser Leu Gly Val Phe Ser Gly
 145                 150                 155                 160
 Arg Asp Gln Pro Ala Pro Gly Glu Glu Ser Phe Glu Val Trp Leu Asp
                 165                 170                 175    
 His Thr Thr Glu Met Leu His Val Trp Gln Gly Val Ser Glu Arg Glu
             180                 185                 190        
 Arg Arg Arg Arg Leu Leu Glu Gly Leu Arg Gly Thr Ala Leu Gln Leu
         195                 200                 205            
 Val His Ala Leu Leu Ala Glu Asn Pro Ala Arg Thr Ala Gln Asp Cys
     210                 215                 220                
 Leu Ala Ala Leu Ala Gln Val Phe Gly Asp Asn Glu Ser Gln Ala Thr
 225                 230                 235                 240
 Ile Arg Val Lys Cys Leu Thr Ala Gln Gln Gln Ser Gly Glu Arg Leu
                 245                 250                 255    
 Ser Ala Phe Val Leu Arg Leu Glu Val Leu Leu Gln Lys Ala Met Glu
             260                 265                 270        
 Lys Glu Ala Leu Ala Arg Ala Ser Ala Asp Arg Val Arg Leu Arg Gln
         275                 280                 285            
 Met Leu Thr Arg Ala His Leu Thr Glu Pro Leu Asp Glu Ala Leu Arg
     290                 295                 300                
 Lys Leu Arg Met Ala Gly Arg Ser Pro Ser Phe Leu Glu Met Leu Gly
 305                 310                 315                 320
 Leu Val Arg Glu Ser Glu Ala Trp Glu Ala Ser Leu Ala Arg Ser Val
                 325                 330                 335    
 Arg Ala Gln Thr Gln Glu Gly Ala Gly Ala Arg Ala Gly Ala Gln Ala
             340                 345                 350        
 Val Ala Arg Ala Ser Thr Lys Val Glu Ala Val Pro Gly Gly Pro Gly
         355                 360                 365            
 Arg Glu Pro Glu Gly Leu Leu Gln Ala Gly Gly Gln Glu Ala Glu Glu
     370                 375                 380                
 Leu Leu Gln Glu Gly Leu Lys Pro Val Leu Glu Glu Cys Asp Asn
 385                 390                 395                



      <210> 587
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 587
 Met His Ser Glu Pro Gly Ala Arg Leu Val Leu Thr Leu Gln Thr Leu
   1               5                  10                  15    
 Ser Arg Ala Leu Ser Asn Leu Lys Ala Cys Trp Gly Cys Asn Val Thr
              20                  25                  30        
 Phe Thr His Ala Gly Pro Phe Gln Lys Ser Ala Arg Ser Cys Asn Trp
          35                  40                  45            
 Cys Tyr Phe Ser Cys Ser Gly Thr Met Cys Ser Thr Thr Gly Val Ser
      50                  55                  60                
 Ala Leu Pro Lys Ser Lys Phe His Leu Ser Ala Lys Cys Arg Gly Ile
  65                  70                  75                  80
 Cys Phe Leu Leu Ser Ser His Arg Ile Val Gly His Leu Phe Ala Gly
                  85                  90                  95    
 Leu Leu Arg Asp Phe Leu Ala Ile Tyr Leu Gln Ala Phe Phe Pro Ser
             100                 105                 110        
 Pro Lys Phe Leu Gly Trp Leu Cys Leu Leu Lys Glu Pro Val Phe Thr
         115                 120                 125            
 Lys Leu His Ser Gly Ala Ser Val Arg Cys Leu Arg Ser Tyr Cys Arg
     130                 135                 140                
 Pro Phe Arg Thr Pro Ser Gln Glu Arg Thr Leu Gln Pro Leu Ala Arg
 145                 150                 155                 160
 Asp Ser Thr Phe Phe Leu Ile Leu Phe Leu Thr Leu Leu Leu Leu Leu
                 165                 170                 175    
 Leu Pro Thr Asn Ser Ile Ser Phe Phe Phe Leu Phe Leu Ser Phe Ser
             180                 185                 190        
 Tyr Ser Ser Phe Pro Pro Ser Leu Ser Cys
         195                 200        



      <210> 588
      <211> 267
      <212> PRT
      <213> Homo sapiens


      <400> 588
 Met Leu Arg Pro Ala Gly Leu Trp Arg Leu Cys Arg Arg Pro Trp Ala
   1               5                  10                  15    
 Ala Arg Val Pro Ala Glu Asn Leu Gly Arg Arg Glu Val Thr Ser Gly
              20                  25                  30        
 Val Ser Pro Arg Gly Ser Thr Ser Pro Arg Thr Leu Asn Ile Phe Asp
          35                  40                  45            
 Arg Asp Leu Lys Arg Lys Gln Lys Asn Trp Ala Ala Arg Gln Pro Glu
      50                  55                  60                
 Pro Thr Lys Phe Asp Tyr Leu Lys Glu Glu Val Gly Ser Arg Ile Ala
  65                  70                  75                  80
 Asp Arg Val Tyr Asp Ile Pro Arg Asn Phe Pro Leu Ala Leu Asp Leu
                  85                  90                  95    
 Gly Cys Gly Arg Gly Tyr Ile Ala Gln Tyr Leu Asn Lys Glu Thr Ile
             100                 105                 110        
 Gly Lys Phe Phe Gln Ala Asp Ile Ala Glu Asn Ala Leu Lys Asn Ser
         115                 120                 125            
 Ser Glu Thr Glu Ile Pro Thr Val Ser Val Leu Ala Asp Glu Glu Phe
     130                 135                 140                
 Leu Pro Phe Lys Glu Asn Thr Phe Asp Leu Val Val Ser Ser Leu Ser
 145                 150                 155                 160
 Leu His Trp Val Asn Asp Leu Pro Arg Ala Leu Glu Gln Ile His Tyr
                 165                 170                 175    
 Ile Leu Lys Pro Asp Gly Val Phe Ile Gly Ala Met Phe Gly Gly Asp
             180                 185                 190        
 Thr Leu Tyr Glu Leu Arg Cys Ser Leu Gln Leu Ala Glu Thr Glu Arg
         195                 200                 205            
 Glu Gly Gly Phe Ser Pro His Ile Ser Pro Phe Thr Ala Val Asn Asp
     210                 215                 220                
 Leu Gly His Leu Leu Gly Arg Ala Gly Phe Asn Thr Leu Thr Val Asp
 225                 230                 235                 240
 Thr Asp Glu Ile Gln Val Asn Tyr Pro Gly Met Phe Glu Leu Met Glu
                 245                 250                 255    
 Asp Leu Gln Glu Gln Lys Ser Arg Met Leu Thr
             260                 265        



      <210> 589
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 589
 Met Leu Arg Pro Ala Gly Leu Trp Arg Leu Cys Arg Arg Pro Trp Ala
   1               5                  10                  15    
 Ala Arg Val Pro Ala Glu Asn Leu Gly Arg Arg Glu Val Thr Ser Gly
              20                  25                  30        
 Val Ser Pro Arg Gly Ser Thr Ser Pro Arg Thr Leu Asn Ile Phe Asp
          35                  40                  45            
 Arg Asp Leu Lys Arg Lys Gln Lys Asn Trp Ala Ala Arg Gln Pro Glu
      50                  55                  60                
 Pro Thr Lys Phe Asp Tyr Leu Lys Glu Glu Val Gly Ser Arg Ile Ala
  65                  70                  75                  80
 Asp Arg Val Tyr Asp Ile Pro Arg Asn Phe Pro Leu Ala Leu Asp Leu
                  85                  90                  95    
 Gly Cys Gly Arg Gly Tyr Ile Ala Gln Tyr Leu Asn Lys Glu Thr Ile
             100                 105                 110        
 Gly Lys Phe Phe Gln Ala Asp Ile Ala Glu Asn Ala Leu Phe Ala Leu
         115                 120                 125            
 Gly Glu
     130



      <210> 590
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 590
 Met Thr Val Gln Leu Val Ser Asn Phe Ser Arg Asp Ala Glu Pro Phe
   1               5                  10                  15    
 Leu Val Arg Thr Leu Val Glu Glu Ile Thr Glu Glu Gln Tyr Tyr Met
              20                  25                  30        
 Met Arg Arg Tyr Glu Ser Ser Ala Ser His Pro Pro Pro Arg Pro Pro
          35                  40                  45            
 Lys His Pro Ser Val Glu Glu Thr Lys Leu Thr Leu Leu Thr Leu Ala
      50                  55                  60                
 Glu Glu Arg Thr Val Asp Leu Pro Lys Ser Pro Lys Arg His His Val
  65                  70                  75                  80
 Asp Ile Thr Lys Lys Leu His Pro Asn Gln Ala Gly Leu Asp Ser Lys
                  85                  90                  95    
 Val Leu Ile Gly Ser Gln Asn Asp Leu Val Asp Glu Glu Lys Glu Arg
             100                 105                 110        
 Ser Asn Arg Gly Ala Thr Ala Ile Ala Glu Thr Phe Lys Asn Glu Lys
         115                 120                 125            
 His Gln Lys
     130    



      <210> 591
      <211> 197
      <212> PRT
      <213> Homo sapiens


      <400> 591
 Met Glu Gln Gln Ser Glu Asp Ala Glu Gly Leu Arg Glu Ser Pro Ala
   1               5                  10                  15    
 Ala Gln Cys Arg Pro Ser Val Arg Ala Gly Ser Ala Gly Arg Ala Arg
              20                  25                  30        
 Leu Arg Gly Ala Ala Leu Glu Glu Thr Glu Ala Ala Gly Gly Pro Glu
          35                  40                  45            
 Ala Gln Glu Glu Asp Glu Asp Glu Glu Glu Ala Leu Pro His Ser Glu
      50                  55                  60                
 Ala Met Asp Val Phe Gln Glu Gly Leu Ala Met Val Val Gln Asp Pro
  65                  70                  75                  80
 Leu Leu Cys Asp Leu Pro Ile Gln Val Thr Leu Glu Glu Val Asn Ser
                  85                  90                  95    
 Gln Ile Ala Leu Glu Tyr Gly Gln Ala Met Thr Val Arg Val Cys Lys
             100                 105                 110        
 Met Asp Gly Glu Val Met Pro Val Val Val Val Gln Ser Ala Thr Val
         115                 120                 125            
 Leu Asp Leu Lys Lys Ala Ile Gln Arg Tyr Val Gln Leu Lys Gln Glu
     130                 135                 140                
 Arg Glu Gly Gly Ile Gln His Ile Ser Trp Ser Tyr Val Trp Arg Thr
 145                 150                 155                 160
 Tyr His Leu Thr Ser Ala Gly Glu Lys Leu Thr Glu Asp Arg Lys Lys
                 165                 170                 175    
 Leu Arg Asp Tyr Gly Ile Arg Asn Arg Asp Glu Val Ser Phe Ile Lys
             180                 185                 190        
 Lys Leu Arg Gln Lys
         195        



      <210> 592
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 592
 Met Gln Cys Phe Ala Ser Leu Tyr Cys Leu Glu Val Ala Glu Leu Gly
   1               5                  10                  15    
 Ala Leu Gly Arg Gly Lys Leu Ala Gly Ser Ala Met Ala Gly Gln Gly
              20                  25                  30        
 Pro Leu Pro Trp Gly Leu Ala Pro Val Pro Ala Cys Pro Ala Pro Glu
          35                  40                  45            
 Val Gly Val Gly Gly Gly Leu Pro Leu Leu Pro Leu Pro Gly Leu Cys
      50                  55                  60                
 Pro Ala Ala Glu Thr Trp Pro Ser His Gln Gln Lys Thr Pro Pro Ser
  65                  70                  75                  80
 Ala Ser Cys Pro Ala Trp Ala Gly Pro Gly Asp Asn Thr Gly Pro Pro
                  85                  90                  95    
 Glu Gly Leu Gln Gly Asp Thr Gln Gln Pro Leu Pro Pro His Cys Pro
             100                 105                 110        
 Pro Ser Glu Gly Ser Leu Pro Glu Pro Ala Pro Cys Gln Val Cys Ala
         115                 120                 125            
 Leu Arg Leu Ala Ala Gly Cys Val Ala Asn Lys Lys Gln Thr
     130                 135                 140        



      <210> 593
      <211> 257
      <212> PRT
      <213> Homo sapiens


      <400> 593
 Met Ala Ala Asp Gly Val Asp Glu Arg Ser Pro Leu Leu Ser Ala Ser
   1               5                  10                  15    
 His Ser Gly Asn Val Thr Pro Thr Ala Pro Pro Tyr Leu Gln Glu Ser
              20                  25                  30        
 Ser Pro Arg Ala Glu Leu Pro Pro Pro Tyr Thr Ala Ile Ala Ser Pro
          35                  40                  45            
 Asp Ala Ser Gly Ile Pro Val Ile Asn Cys Arg Val Cys Gln Ser Leu
      50                  55                  60                
 Ile Asn Leu Asp Gly Lys Leu His Gln His Val Val Lys Cys Thr Val
  65                  70                  75                  80
 Cys Asn Glu Ala Thr Pro Ile Lys Asn Pro Pro Thr Gly Lys Lys Tyr
                  85                  90                  95    
 Val Arg Cys Pro Cys Asn Cys Leu Leu Ile Cys Lys Asp Thr Ser Arg
             100                 105                 110        
 Arg Ile Gly Cys Pro Arg Pro Asn Cys Arg Arg Ile Ile Asn Leu Gly
         115                 120                 125            
 Pro Val Met Leu Ile Ser Glu Glu Gln Pro Ala Gln Pro Ala Leu Pro
     130                 135                 140                
 Ile Gln Pro Glu Gly Thr Arg Val Val Cys Gly His Cys Gly Asn Thr
 145                 150                 155                 160
 Phe Leu Trp Met Glu Leu Arg Phe Asn Thr Leu Ala Lys Cys Pro His
                 165                 170                 175    
 Cys Lys Lys Ile Ser Ser Val Gly Ser Ala Leu Pro Arg Arg Arg Cys
             180                 185                 190        
 Cys Ala Tyr Ile Thr Ile Gly Met Ile Cys Ile Phe Ile Gly Val Gly
         195                 200                 205            
 Leu Thr Val Gly Thr Pro Asp Phe Ala Arg Arg Phe Arg Ala Thr Tyr
     210                 215                 220                
 Val Ser Trp Ala Ile Ala Tyr Leu Leu Gly Leu Ile Cys Leu Ile Arg
 225                 230                 235                 240
 Ala Cys Tyr Trp Gly Ala Ile Arg Val Ser Tyr Pro Glu His Ser Phe
                 245                 250                 255    
 Ala
    



      <210> 594
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 594
 Met Gly Arg Ser Arg Arg Thr Gly Ala His Arg Ala His Ser Leu Ala
   1               5                  10                  15    
 Arg Gln Met Lys Ala Lys Arg Arg Arg Pro Asp Leu Asp Glu Ile His
              20                  25                  30        
 Arg Glu Leu Arg Pro Gln Gly Ser Ala Arg Pro Gln Pro Asp Pro Asn
          35                  40                  45            
 Ala Glu Phe Asp Pro Asp Leu Pro Gly Gly Gly Leu His Arg Cys Leu
      50                  55                  60                
 Ala Cys Ala Arg Tyr Phe Ile Asp Ser Thr Asn Leu Lys Thr His Phe
  65                  70                  75                  80
 Arg Ser Lys Asp His Lys Lys Arg Leu Lys Gln Leu Ser Val Glu Pro
                  85                  90                  95    
 Tyr Ser Gln Glu Glu Ala Glu Arg Ala Ala Gly Met Gly Ser Tyr Val
             100                 105                 110        
 Pro Pro Arg Arg Leu Ala Val Pro Thr Glu Val Ser Thr Glu Val Pro
         115                 120                 125            
 Glu Met Asp Thr Ser Thr
     130                



      <210> 595
      <211> 251
      <212> PRT
      <213> Homo sapiens


      <400> 595
 Met Gly Leu Leu Ser Leu Trp Asp Gln Pro Gln Glu Glu Ser Glu Glu
   1               5                  10                  15    
 Gln Pro Val Phe Arg Leu Val Pro Cys Ile Leu Glu Ala Ala Lys Gln
              20                  25                  30        
 Val Arg Ser Glu Asn Pro Glu Trp Leu Asp Val Tyr Met His Ile Leu
          35                  40                  45            
 Gln Leu Leu Thr Thr Val Asp Asp Gly Ile Gln Ala Ile Val His Cys
      50                  55                  60                
 Pro Asp Thr Gly Lys Asp Ile Trp Asn Leu Leu Phe Asp Leu Val Cys
  65                  70                  75                  80
 His Glu Phe Cys Gln Ser Asp Asp Pro Pro Ile Ile Leu Gln Glu Gln
                  85                  90                  95    
 Lys Thr Val Leu Ala Ser Val Phe Ser Val Leu Ser Ala Ile Tyr Ala
             100                 105                 110        
 Ser Gln Thr Glu Gln Glu Tyr Leu Lys Ile Glu Lys Val Asp Leu Pro
         115                 120                 125            
 Leu Ile Asp Ser Leu Ile Arg Val Leu Gln Asn Met Glu Gln Cys Gln
     130                 135                 140                
 Lys Lys Pro Glu Asn Ser Ala Glu Ser Asn Thr Glu Glu Thr Lys Arg
 145                 150                 155                 160
 Thr Asp Leu Thr Gln Asp Asp Phe His Leu Lys Ile Leu Lys Asp Ile
                 165                 170                 175    
 Leu Cys Glu Phe Leu Ser Asn Ile Phe Gln Ala Leu Thr Lys Glu Thr
             180                 185                 190        
 Val Ala Gln Gly Val Lys Glu Gly Gln Leu Ser Lys Gln Lys Cys Ser
         195                 200                 205            
 Ser Ala Phe Gln Asn Leu Leu Pro Phe Tyr Ser Pro Val Val Glu Asp
     210                 215                 220                
 Phe Ile Lys Ile Leu Arg Glu Val Asp Lys Ala Leu Ala Asp Asp Leu
 225                 230                 235                 240
 Glu Lys Asn Phe Pro Ser Leu Lys Val Gln Thr
                 245                 250    



      <210> 596
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 596
 Met Ser Ser Asp Phe Glu Gly Tyr Glu Gln Asp Phe Ala Val Leu Thr
   1               5                  10                  15    
 Ala Glu Ile Thr Ser Lys Ile Ala Arg Val Pro Arg Leu Pro Pro Asp
              20                  25                  30        
 Glu Lys Lys Gln Met Val Ala Asn Val Glu Lys Gln Leu Glu Glu Ala
          35                  40                  45            
 Lys Glu Leu Leu Glu Gln Met Asp Leu Glu Val Arg Glu Ile Pro Pro
      50                  55                  60                
 Gln Ser Arg Gly Met Tyr Ser Asn Arg Met Arg Ser Tyr Lys Gln Glu
  65                  70                  75                  80
 Met Gly Lys Leu Glu Thr Asp Phe Lys Arg Ser Arg Ile Ala Tyr Ser
                  85                  90                  95    
 Asp Glu Val Arg Asn Glu Leu Leu Gly Asp Asp Gly Asn Ser Ser Glu
             100                 105                 110        
 Asn Gln Arg Ala His Leu Leu Asp Asn Thr Glu Arg Leu Glu Arg Ser
         115                 120                 125            
 Ser Arg Arg Leu Glu Ala Gly Tyr Gln Ile Ala Val Glu Thr Gly Lys
     130                 135                 140                
 Asn Ser Glu Ser Glu Gln Ile Val Leu Leu Met His Ser Ser Leu His
 145                 150                 155                 160
 Asn Thr
        



      <210> 597
      <211> 326
      <212> PRT
      <213> Homo sapiens


      <400> 597
 Met Arg Met Thr Leu Leu Cys Val Lys Thr Trp Ser Tyr Lys Thr Glu
   1               5                  10                  15    
 Ile Cys Pro Pro Lys Lys Lys Ile Phe Leu Arg Glu Phe Pro Arg Leu
              20                  25                  30        
 Lys Glu Asp Leu Lys Gly Asn Ile Asp Lys Leu Arg Ala Leu Ala Asp
          35                  40                  45            
 Asp Ile Asp Lys Thr His Lys Lys Phe Thr Lys Ala Asn Met Val Ala
      50                  55                  60                
 Thr Ser Thr Ala Val Ile Ser Gly Val Met Ser Leu Leu Gly Leu Ala
  65                  70                  75                  80
 Leu Ala Pro Ala Thr Gly Gly Gly Ser Leu Leu Leu Ser Thr Ala Gly
                  85                  90                  95    
 Gln Gly Leu Ala Thr Ala Ala Gly Val Thr Ser Ile Val Ser Gly Thr
             100                 105                 110        
 Leu Glu Arg Ser Lys Asn Lys Glu Ala Gln Ala Arg Ala Glu Asp Ile
         115                 120                 125            
 Leu Pro Thr Tyr Asp Gln Glu Asp Arg Glu Asp Glu Glu Glu Lys Ala
     130                 135                 140                
 Asp Tyr Val Thr Ala Ala Gly Lys Ile Ile Tyr Asn Leu Arg Asn Thr
 145                 150                 155                 160
 Leu Lys Tyr Ala Lys Lys Asn Val Arg Ala Phe Trp Lys Leu Arg Ala
                 165                 170                 175    
 Asn Pro Arg Leu Ala Asn Ala Thr Lys Arg Leu Leu Thr Thr Gly Gln
             180                 185                 190        
 Val Ser Ser Arg Ser Arg Val Gln Val Gln Lys Ala Phe Ala Gly Thr
         195                 200                 205            
 Thr Leu Ala Met Thr Lys Asn Ala Arg Val Leu Gly Gly Val Met Ser
     210                 215                 220                
 Ala Phe Ser Leu Gly Tyr Asp Leu Ala Thr Leu Ser Lys Glu Trp Lys
 225                 230                 235                 240
 His Leu Lys Glu Gly Ala Arg Thr Lys Phe Ala Glu Glu Leu Arg Ala
                 245                 250                 255    
 Lys Ala Leu Glu Leu Glu Arg Lys Leu Thr Glu Leu Thr Gln Leu Tyr
             260                 265                 270        
 Lys Ser Leu Gln Gln Lys Val Arg Ser Arg Ala Arg Gly Val Gly Lys
         275                 280                 285            
 Asp Leu Thr Gly Thr Cys Glu Thr Glu Ala Tyr Trp Lys Glu Leu Arg
     290                 295                 300                
 Glu His Val Trp Met Trp Leu Trp Leu Cys Val Cys Leu Cys Val Cys
 305                 310                 315                 320
 Val Tyr Val Gln Phe Thr
                 325    



      <210> 598
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 598
 Met Phe Thr Ile Glu Asn Asn Phe Val Leu Lys Asn Lys Asp Ser Phe
   1               5                  10                  15    
 Ser Arg Val Gly Pro Val Pro Thr Tyr Val Leu Pro Ala Asn Trp Thr
              20                  25                  30        
 Gly Thr Tyr Thr Val Val Tyr Leu Ala Pro Glu Ile Asn Ile Ala Pro
          35                  40                  45            
 Asn Asn Gln Ser Phe Ile Ile Leu Leu Thr Ala Thr Thr Arg His Lys
      50                  55                  60                





      <210> 599
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 599
 Met Glu Glu Glu Ala Glu Thr Glu Glu Gln Gln Arg Phe Ser Tyr Gln
   1               5                  10                  15    
 Gln Arg Leu Lys Ala Ala Val His Tyr Thr Val Gly Cys Leu Cys Glu
              20                  25                  30        
 Glu Val Ala Leu Asp Lys Glu Met Gln Phe Ser Lys Gln Thr Ile Ala
          35                  40                  45            
 Ala Ile Ser Glu Leu Thr Phe Arg Gln Cys Glu Asn Phe Ala Lys Asp
      50                  55                  60                
 Leu Glu Met Phe Ala Arg His Ala Lys Arg Thr Thr Ile Asn Thr Glu
  65                  70                  75                  80
 Asp Val Lys Leu Leu Ala Arg Arg Ser Asn Ser Leu Leu Lys Tyr Ile
                  85                  90                  95    
 Thr Asp Lys Ser Glu Glu Ile Ala Gln Ile Asn Leu Glu Arg Lys Ala
             100                 105                 110        
 Gln Lys Lys Lys Lys Ser Glu Asp Gly Ser Lys Asn Ser Arg Gln Pro
         115                 120                 125            
 Ala Glu Ala Gly Val Val Glu Ser Glu Asn
     130                 135            



      <210> 600
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 600
 Met Met Asp Val Ser Gly Val Gly Phe Pro Ser Lys Val Pro Trp Lys
   1               5                  10                  15    
 Lys Met Ser Ala Glu Glu Leu Glu Asn Gln Tyr Cys Pro Ser Arg Trp
              20                  25                  30        
 Val Val Arg Leu Gly Ala Glu Glu Ala Leu Arg Thr Tyr Ser Gln Ile
          35                  40                  45            
 Gly Ile Glu Ala Thr Thr Arg Ala Arg Ala Thr Arg Lys Ser Leu Leu
      50                  55                  60                
 His Val Pro Tyr Gly Asp Gly Glu Gly Glu Lys Val Asp Ile Tyr Phe
  65                  70                  75                  80
 Pro Asp Glu Ser Ser Glu Ala Leu Pro Phe Phe Leu Phe Phe His Gly
                  85                  90                  95    
 Gly Tyr Trp Gln Ser Gly Arg Pro Cys Val Lys Glu Ser Gly Lys Pro
             100                 105                 110        
 His Leu Lys Ser Ser Thr Met Trp Thr Thr Leu Lys Leu Leu Arg Ile
         115                 120                 125            





      <210> 601
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 601
 Met Met Asp Val Ser Gly Val Gly Phe Pro Ser Lys Val Pro Trp Lys
   1               5                  10                  15    
 Lys Met Ser Ala Glu Glu Leu Glu Asn Gln Tyr Cys Pro Ser Arg Trp
              20                  25                  30        
 Val Val Arg Leu Gly Ala Glu Glu Ala Leu Arg Thr Tyr Ser Gln Ile
          35                  40                  45            
 Gly Ile Glu Ala Thr Thr Arg Ala Arg Ala Thr Arg Lys Ser Leu Leu
      50                  55                  60                
 His Val Pro Tyr Gly Asp Gly Glu Gly Glu Lys Val Asp Ile Tyr Phe
  65                  70                  75                  80
 Pro Asp Glu Ser Ser Glu Ala Leu Pro Phe Phe Leu Phe Phe His Gly
                  85                  90                  95    
 Gly Tyr Trp Gln Ser Gly Arg His Pro Gly Pro His Gly Arg Pro Gly
             100                 105                 110        
 Asp Pro Gln Arg Cys Val Cys Pro Glu Ala Val Ser Lys Gln Gln Thr
         115                 120                 125            
 Leu Cys Gln Gly Glu Trp Lys Ala Ser Phe Glu Glu Leu His Asp Val
     130                 135                 140                
 Asp His Phe Glu Ile Val Glu Asn Leu Thr Gln Lys Asp Asn Val Leu
 145                 150                 155                 160
 Thr Gln Ile Ile Leu Lys Thr Ile Phe Gln
                 165                 170



      <210> 602
      <211> 52
      <212> PRT
      <213> Homo sapiens


      <400> 602
 Met Glu Leu Ser Ser Ser Ser Ser Pro Ser Val Ser His Ile Leu Gln
   1               5                  10                  15    
 Ser Trp Pro Leu Arg Glu Thr Pro Thr Gln His Lys Ile Ser His Leu
              20                  25                  30        
 Phe Leu Arg His Pro Pro Ala Gln Tyr Ile Tyr Pro Leu Ala Arg Glu
          35                  40                  45            
 Pro Ser Gly His
      50        



      <210> 603
      <211> 1243
      <212> PRT
      <213> Homo sapiens


      <400> 603
 Met Asn Arg Ala Lys Pro Thr Thr Val Arg Arg Pro Ser Ala Ala Ala
   1               5                  10                  15    
 Lys Pro Ser Gly His Pro Pro Pro Gly Asp Phe Ile Ala Leu Gly Ser
              20                  25                  30        
 Lys Gly Gln Ala Asn Glu Ser Lys Thr Ala Ser Thr Leu Leu Lys Pro
          35                  40                  45            
 Ala Pro Ser Gly Leu Pro Ser Glu Arg Lys Arg Asp Ala Ala Ala Ala
      50                  55                  60                
 Leu Ser Ser Ala Ser Ala Leu Thr Gly Leu Thr Lys Arg Pro Lys Leu
  65                  70                  75                  80
 Ser Ser Thr Pro Pro Leu Ser Ala Leu Gly Arg Leu Ala Glu Ala Ala
                  85                  90                  95    
 Val Ala Glu Lys Arg Ala Ile Ser Pro Ser Ile Lys Glu Pro Ser Val
             100                 105                 110        
 Val Pro Ile Glu Val Leu Pro Thr Val Leu Leu Asp Glu Ile Glu Ala
         115                 120                 125            
 Ala Glu Leu Glu Gly Asn Asp Asp Arg Ile Glu Gly Val Leu Cys Gly
     130                 135                 140                
 Ala Val Lys Gln Leu Lys Val Thr Arg Ala Lys Pro Asp Ser Thr Leu
 145                 150                 155                 160
 Tyr Leu Ser Leu Met Tyr Leu Ala Lys Ile Lys Pro Asn Ile Phe Ala
                 165                 170                 175    
 Thr Glu Gly Val Ile Glu Ala Leu Cys Ser Leu Leu Arg Arg Asp Ala
             180                 185                 190        
 Ser Ile Asn Phe Lys Ala Lys Gly Asn Ser Leu Val Ser Val Leu Ala
         195                 200                 205            
 Cys Asn Leu Leu Met Ala Ala Tyr Glu Glu Asp Glu Asn Trp Pro Glu
     210                 215                 220                
 Ile Phe Val Lys Val Tyr Ile Glu Asp Ser Leu Gly Glu Arg Ile Trp
 225                 230                 235                 240
 Val Asp Ser Pro His Cys Lys Thr Phe Val Asp Asn Ile Gln Thr Ala
                 245                 250                 255    
 Phe Asn Thr Arg Met Pro Pro Arg Ser Val Leu Leu Gln Gly Glu Ala
             260                 265                 270        
 Gly Arg Val Ala Gly Asp Leu Gly Ala Gly Ser Ser Pro His Pro Ser
         275                 280                 285            
 Leu Thr Glu Glu Glu Asp Ser Gln Thr Glu Leu Leu Ile Ala Glu Glu
     290                 295                 300                
 Lys Leu Ser Pro Glu Gln Glu Gly Gln Leu Met Pro Arg Tyr Glu Glu
 305                 310                 315                 320
 Leu Ala Glu Ser Val Glu Glu Tyr Val Leu Asp Met Leu Arg Asp Gln
                 325                 330                 335    
 Leu Asn Arg Arg Gln Pro Ile Asp Asn Val Ser Arg Asn Leu Leu Arg
             340                 345                 350        
 Leu Leu Thr Ser Thr Cys Gly Tyr Lys Glu Val Arg Leu Leu Ala Val
         355                 360                 365            
 Gln Lys Leu Glu Met Trp Leu Gln Asn Pro Lys Leu Thr Arg Pro Ala
     370                 375                 380                
 Gln Asp Leu Leu Met Ser Val Cys Met Asn Cys Asn Thr His Gly Ser
 385                 390                 395                 400
 Glu Asp Met Asp Val Ile Ser His Leu Ile Lys Ile Arg Leu Lys Pro
                 405                 410                 415    
 Lys Val Leu Leu Asn His Phe Met Leu Cys Ile Arg Glu Leu Leu Ser
             420                 425                 430        
 Ala His Lys Asp Asn Leu Gly Thr Thr Ile Lys Leu Val Ile Phe Asn
         435                 440                 445            
 Glu Leu Ser Ser Ala Arg Asn Pro Asn Asn Met Gln Val Leu Tyr Thr
     450                 455                 460                
 Ala Leu Gln His Ser Ser Glu Leu Ala Pro Lys Phe Leu Ala Met Val
 465                 470                 475                 480
 Phe Gln Asp Leu Leu Thr Asn Lys Asp Asp Tyr Leu Arg Ala Ser Arg
                 485                 490                 495    
 Ala Leu Leu Arg Glu Ile Ile Lys Gln Thr Lys His Glu Ile Asn Phe
             500                 505                 510        
 Gln Ala Phe Cys Leu Gly Leu Met Gln Glu Arg Lys Glu Pro Gln Tyr
         515                 520                 525            
 Leu Glu Met Glu Phe Lys Thr Pro Cys Arg Ala His Val Gly Val Glu
     530                 535                 540                
 Trp Gly Ser Arg Val Ser Leu Leu Asp Thr Asp Pro Val Leu His Leu
 545                 550                 555                 560
 Gln Glu Arg Phe Val Val His Ile Thr Asp Val Leu Ala Val Ser Met
                 565                 570                 575    
 Met Leu Gly Ile Thr Ala Gln Val Lys Glu Ala Gly Ile Ala Trp Asp
             580                 585                 590        
 Lys Gly Glu Lys Arg Asn Leu Glu Val Leu Arg Ser Phe Gln Asn Gln
         595                 600                 605            
 Ile Ala Ala Ile Gln Arg Asp Ala Val Trp Trp Leu His Thr Val Val
     610                 615                 620                
 Pro Ser Ile Ser Lys Leu Ala Pro Lys Asp Tyr Val His Cys Leu His
 625                 630                 635                 640
 Lys Val Leu Phe Thr Glu Gln Pro Glu Thr Tyr Tyr Lys Trp Asp Asn
                 645                 650                 655    
 Trp Pro Pro Glu Ser Asp Arg Asn Phe Phe Leu Arg Leu Cys Ser Glu
             660                 665                 670        
 Val Pro Ile Leu Glu Asp Thr Leu Met Arg Ile Leu Val Ile Gly Leu
         675                 680                 685            
 Ser Arg Glu Leu Pro Leu Gly Pro Ala Asp Ala Met Glu Leu Ala Asp
     690                 695                 700                
 His Leu Val Lys Arg Ala Ala Ala Val Gln Ala Asp Asp Val Glu Val
 705                 710                 715                 720
 Leu Lys Val Gly Arg Thr Gln Leu Ile Asp Ala Val Leu Asn Leu Cys
                 725                 730                 735    
 Thr Tyr His His Pro Glu Asn Ile Gln Leu Pro Pro Gly Tyr Gln Pro
             740                 745                 750        
 Pro Asn Leu Ala Ile Ser Thr Leu Tyr Trp Lys Ala Trp Pro Leu Leu
         755                 760                 765            
 Leu Val Val Ala Ala Phe Asn Pro Glu Asn Ile Gly Leu Ala Ala Trp
     770                 775                 780                
 Glu Glu Tyr Pro Thr Leu Lys Met Leu Met Glu Met Val Met Thr Asn
 785                 790                 795                 800
 Asn Tyr Ser Tyr Pro Pro Cys Thr Leu Thr Asp Glu Glu Thr Arg Thr
                 805                 810                 815    
 Glu Met Leu Asn Arg Glu Leu Gln Thr Ala Gln Arg Glu Lys Gln Glu
             820                 825                 830        
 Ile Leu Ala Phe Glu Gly His Leu Ala Ala Ala Ser Thr Lys Gln Thr
         835                 840                 845            
 Ile Thr Glu Ser Ser Ser Leu Leu Leu Ser Gln Leu Thr Ser Leu Asp
     850                 855                 860                
 Pro Gln Gly Pro Pro Arg Arg Pro Pro Pro His Ile Leu Asp Gln Val
 865                 870                 875                 880
 Lys Ser Leu Asn Gln Ser Leu Arg Leu Gly His Leu Leu Cys Arg Ser
                 885                 890                 895    
 Arg Asn Pro Asp Phe Leu Leu His Ile Ile Gln Arg Gln Ala Ser Ser
             900                 905                 910        
 Gln Ser Met Pro Trp Leu Ala Asp Leu Val Gln Ser Ser Glu Gly Ser
         915                 920                 925            
 Leu Asp Val Leu Pro Val Gln Cys Leu Cys Glu Phe Leu Leu His Asp
     930                 935                 940                
 Ala Val Asp Asp Ala Ala Ser Gly Glu Glu Asp Asp Glu Gly Glu Ser
 945                 950                 955                 960
 Lys Glu Gln Lys Ala Lys Lys Arg Gln Arg Gln Gln Lys Gln Arg Gln
                 965                 970                 975    
 Leu Leu Gly Arg Leu Gln Asp Leu Leu Leu Gly Pro Lys Ala Asp Glu
             980                 985                 990        
 Gln Thr Thr Cys Glu Val Leu Asp Tyr Phe Leu Arg Arg Leu Gly Ser
         995                1000                1005            
 Ser Gln Val Ala Ser Arg Val Leu Ala Met Lys Gly Leu Ser Leu Val
    1010                1015                1020                
 Leu Ser Glu Gly Ser Leu Arg Asp Gly Glu Glu Lys Glu Pro Pro Met
1025                1030                1035                1040
 Glu Glu Asp Val Gly Asp Thr Asp Val Leu Gln Gly Tyr Gln Trp Leu
                1045                1050                1055    
 Leu Arg Asp Leu Pro Arg Leu Pro Leu Phe Asp Ser Val Arg Ser Thr
            1060                1065                1070        
 Thr Ala Leu Ala Leu Gln Gln Ala Ile His Met Glu Thr Asp Pro Gln
        1075                1080                1085            
 Thr Ile Ser Ala Tyr Leu Ile Tyr Leu Ser Gln His Thr Pro Val Glu
    1090                1095                1100                
 Glu Gln Ala Gln His Ser Asp Leu Ala Leu Asp Val Ala Arg Leu Val
1105                1110                1115                1120
 Val Glu Arg Ser Thr Ile Met Ser His Leu Phe Ser Lys Leu Ser Pro
                1125                1130                1135    
 Ser Ala Ala Ser Asp Ala Val Leu Ser Ala Leu Leu Ser Ile Phe Ser
            1140                1145                1150        
 Arg Tyr Val Arg Arg Met Arg Gln Ser Lys Glu Gly Glu Glu Val Tyr
        1155                1160                1165            
 Ser Trp Ser Glu Ser Gln Asp Gln Val Phe Leu Arg Trp Ser Ser Gly
    1170                1175                1180                
 Glu Thr Ala Thr Met His Ile Leu Val Val His Ala Met Val Ile Leu
1185                1190                1195                1200
 Leu Thr Leu Gly Pro Pro Arg Ala Asp Asp Ser Glu Phe Gln Ala Leu
                1205                1210                1215    
 Leu Asp Ile Trp Phe Pro Glu Glu Lys Pro Leu Pro Thr Ala Phe Leu
            1220                1225                1230        
 Val Asp Thr Ser Glu Ala Gly Ala Ala Ala Ser
        1235                1240            



      <210> 604
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 604
 Met Tyr Leu Leu Ser Phe Cys Phe Thr Ile Glu Val Asp Gly Thr Leu
   1               5                  10                  15    
 Asn Phe Trp Val His Gly Asn Met Leu Lys Thr Glu His Asn Pro Asp
              20                  25                  30        
 His His Ser Cys Leu Ala Val Ser Trp Glu Ala Ala Gly Cys His Gly
          35                  40                  45            
 Ala Gly Thr Gln Gln Ser Pro Leu Gly Val Ala Gly Pro Trp Arg Pro
      50                  55                  60                
 Arg Pro Pro Cys Val Gly Ser Leu Leu Ala Ala Arg Ser Leu His Lys
  65                  70                  75                  80
 Gln Val Ile Leu Phe Gly Leu Leu Ser Phe Ala Tyr Asp Leu Gln Pro
                  85                  90                  95    
 Asn Leu Gly Cys Arg Gly Ser Ser Ala Gly Pro Cys Ser Phe Val Cys
             100                 105                 110        
 Trp Val Thr Leu Met Ala Gly His Ile Pro Leu Ser Pro Ser Tyr Ser
         115                 120                 125            
 Phe Thr Asp Leu Ser Lys Phe
     130                 135



      <210> 605
      <211> 91
      <212> PRT
      <213> Homo sapiens


      <400> 605
 Met Pro Gln Asn Leu Ser Ser Ser Pro His Ser Pro Trp Gln Gly Pro
   1               5                  10                  15    
 Asp His Pro Tyr Met Gln His Ala Val Pro Pro Ala Pro Pro Ile Ala
              20                  25                  30        
 Met Ala Lys Gln Val Pro Leu Gly His Gly Gly Ile Thr Trp Asp Ala
          35                  40                  45            
 Cys Val Ile Asp His Leu Ala Phe Ser Leu Pro Ser Arg Pro Pro Pro
      50                  55                  60                
 Glu Ser Leu Pro Arg Thr Pro Glu Leu Leu Ala Gln Gly Pro Val Ser
  65                  70                  75                  80
 Leu Leu Thr Pro Glu Lys His Pro Arg Ala Leu
                  85                  90    



      <210> 606
      <211> 225
      <212> PRT
      <213> Homo sapiens


      <400> 606
 Met Leu Leu Ser Gly Ser Gly Gly Asp Gly Val Ser Ala Lys Met Ser
   1               5                  10                  15    
 Thr Ala Ala Val Pro Glu Leu Lys Gln Ile Ser Arg Val Glu Ala Met
              20                  25                  30        
 Arg Leu Gly Pro Gly Trp Ser His Ser Cys His Ala Met Leu Tyr Ala
          35                  40                  45            
 Ala Asn Pro Gly Gln Leu Phe Gly Arg Ile Pro Met Arg Phe Ser Val
      50                  55                  60                
 Leu Met Gln Met Arg Phe Asp Gly Leu Leu Gly Phe Pro Gly Gly Phe
  65                  70                  75                  80
 Val Asp Arg Arg Phe Trp Ser Leu Glu Asp Gly Leu Asn Arg Val Leu
                  85                  90                  95    
 Gly Leu Gly Leu Gly Cys Leu Arg Leu Thr Glu Ala Asp Tyr Leu Ser
             100                 105                 110        
 Ser His Leu Thr Glu Gly Pro His Arg Val Val Ala His Leu Tyr Ala
         115                 120                 125            
 Arg Gln Leu Thr Leu Glu Gln Leu His Ala Val Glu Ile Ser Ala Val
     130                 135                 140                
 His Ser Arg Asp His Gly Leu Glu Val Leu Gly Leu Val Arg Val Pro
 145                 150                 155                 160
 Leu Tyr Thr Gln Lys Asp Arg Val Gly Gly Phe Pro Asn Phe Leu Ser
                 165                 170                 175    
 Asn Ala Phe Val Ser Thr Ala Lys Cys Gln Leu Leu Phe Ala Leu Lys
             180                 185                 190        
 Val Leu Asn Met Met Pro Glu Glu Lys Leu Val Glu Ala Leu Ala Ala
         195                 200                 205            
 Ala Thr Glu Lys Gln Lys Lys Ala Leu Glu Lys Leu Leu Pro Ala Ser
     210                 215                 220                
 Ser
 225



      <210> 607
      <211> 505
      <212> PRT
      <213> Homo sapiens


      <400> 607
 Met Lys Arg Thr Pro Thr Ala Glu Glu Arg Glu Arg Glu Ala Lys Lys
   1               5                  10                  15    
 Leu Arg Leu Leu Glu Glu Leu Glu Asp Thr Trp Leu Pro Tyr Leu Thr
              20                  25                  30        
 Pro Lys Asp Asp Glu Phe Tyr Gln Gln Trp Gln Leu Lys Tyr Pro Lys
          35                  40                  45            
 Leu Ile Leu Arg Glu Ala Ser Ser Val Ser Glu Glu Leu His Lys Glu
      50                  55                  60                
 Val Gln Glu Ala Phe Leu Thr Leu His Lys His Gly Cys Leu Phe Arg
  65                  70                  75                  80
 Asp Leu Val Arg Ile Gln Gly Lys Asp Leu Leu Thr Pro Val Ser Arg
                  85                  90                  95    
 Ile Leu Ile Gly Asn Pro Gly Cys Thr Tyr Lys Tyr Leu Asn Thr Arg
             100                 105                 110        
 Leu Phe Thr Val Pro Trp Pro Val Lys Gly Ser Asn Ile Lys His Thr
         115                 120                 125            
 Glu Ala Glu Ile Ala Ala Ala Cys Glu Thr Phe Leu Lys Leu Asn Asp
     130                 135                 140                
 Tyr Leu Gln Ile Glu Thr Ile Gln Ala Leu Glu Glu Leu Ala Ala Lys
 145                 150                 155                 160
 Glu Lys Ala Asn Glu Asp Ala Val Pro Leu Cys Met Ser Ala Asp Phe
                 165                 170                 175    
 Pro Arg Val Gly Met Gly Ser Ser Tyr Asn Gly Gln Asp Glu Val Asp
             180                 185                 190        
 Ile Lys Ser Arg Ala Ala Tyr Asn Val Thr Leu Leu Asn Phe Met Asp
         195                 200                 205            
 Pro Gln Lys Met Pro Tyr Leu Lys Glu Glu Pro Tyr Phe Gly Met Gly
     210                 215                 220                
 Lys Met Ala Val Ser Trp His His Asp Glu Asn Leu Val Asp Arg Ser
 225                 230                 235                 240
 Ala Val Ala Val Tyr Ser Tyr Ser Cys Glu Gly Pro Glu Glu Glu Ser
                 245                 250                 255    
 Glu Asp Asp Ser His Leu Glu Gly Arg Asp Pro Asp Ile Trp His Val
             260                 265                 270        
 Gly Phe Lys Ile Ser Trp Asp Ile Glu Thr Pro Gly Leu Ala Ile Pro
         275                 280                 285            
 Leu His Gln Gly Asp Cys Tyr Phe Met Leu Asp Asp Leu Asn Ala Thr
     290                 295                 300                
 His Gln His Cys Val Leu Ala Gly Ser Gln Pro Arg Phe Ser Ser Thr
 305                 310                 315                 320
 His Arg Val Ala Glu Cys Ser Thr Gly Thr Leu Asp Tyr Ile Leu Gln
                 325                 330                 335    
 Arg Cys Gln Leu Ala Leu Gln Asn Val Cys Asp Asp Val Asp Asn Asp
             340                 345                 350        
 Asp Val Ser Leu Lys Ser Phe Glu Pro Ala Val Leu Lys Gln Gly Glu
         355                 360                 365            
 Glu Ile His Asn Glu Val Glu Phe Glu Trp Leu Arg Gln Phe Trp Phe
     370                 375                 380                
 Gln Gly Asn Arg Tyr Arg Lys Cys Thr Asp Trp Trp Cys Gln Pro Met
 385                 390                 395                 400
 Ala Gln Leu Glu Ala Leu Trp Lys Lys Met Glu Gly Val Thr Asn Ala
                 405                 410                 415    
 Val Leu His Glu Val Lys Arg Glu Gly Leu Pro Val Glu Gln Arg Asn
             420                 425                 430        
 Glu Ile Leu Thr Ala Ile Leu Ala Ser Leu Thr Ala Arg Gln Asn Leu
         435                 440                 445            
 Arg Arg Glu Trp His Ala Arg Cys Gln Ser Arg Ile Ala Arg Thr Leu
     450                 455                 460                
 Pro Ala Asp Gln Lys Pro Glu Cys Arg Pro Tyr Trp Glu Lys Asp Asp
 465                 470                 475                 480
 Ala Ser Met Pro Leu Pro Phe Asp Leu Thr Asp Ile Val Ser Glu Leu
                 485                 490                 495    
 Arg Gly Gln Leu Leu Glu Ala Lys Pro
             500                 505



      <210> 608
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 608
 Met Ser Gln Lys Gln Glu Glu Glu Asn Pro Ala Glu Glu Thr Gly Glu
   1               5                  10                  15    
 Glu Lys Gln Asp Thr Gln Glu Lys Glu Gly Ile Leu Pro Glu Arg Ala
              20                  25                  30        
 Glu Glu Ala Lys Leu Lys Ala Lys Tyr Pro Ser Leu Gly Gln Lys Pro
          35                  40                  45            
 Gly Gly Ser Asp Phe Leu Met Lys Arg Leu Gln Lys Gly Val Trp Gly
      50                  55                  60                
 Ile Val Ser Tyr Pro Leu Ser Leu Glu Leu Lys Glu Val Leu Arg Met
  65                  70                  75                  80
 Lys Ser Val Glu Val Leu Leu Asp Pro Phe Leu Glu Val Leu Leu Leu
                  85                  90                  95    
 Asn Arg Ser Arg Gly Glu Phe Glu Ile
             100                 105



      <210> 609
      <211> 549
      <212> PRT
      <213> Homo sapiens


      <400> 609
 Met Val Ala Ala Pro Arg Leu Gly Leu Ser Tyr Ser Lys Ser Leu Asn
   1               5                  10                  15    
 Pro Gly Arg Gly Asp Thr Trp Asp Phe Arg Thr Leu Leu Arg Gly Leu
              20                  25                  30        
 Pro Gly Leu Leu Ser Pro Arg Glu Pro Leu Ala Val His Thr Trp Ala
          35                  40                  45            
 Pro Thr Pro Gln Gly Leu Leu Leu Leu Asp Phe Gly Gly Thr Val Ser
      50                  55                  60                
 Leu Leu Gln Ser His Gly Gly Thr Arg Ala Val Gly Thr Leu Gln Glu
  65                  70                  75                  80
 Ala Pro Val Gly Pro Trp Gly Ser Ala Ala Leu Gly Thr Phe Gln Gly
                  85                  90                  95    
 Thr Leu Ala Cys Val Leu Gly Ser Thr Leu Glu Leu Leu Asp Met Gly
             100                 105                 110        
 Ser Gly Gln Leu Leu Glu Arg Lys Val Leu Ser Thr Asp Arg Val His
         115                 120                 125            
 Leu Leu Glu Pro Pro Ala Pro Gly Met Glu Asp Glu Glu Glu Leu Glu
     130                 135                 140                
 Thr Arg Gly Asn Leu Arg Leu Leu Ser Ala Leu Gly Leu Phe Cys Val
 145                 150                 155                 160
 Gly Trp Glu Ala Pro Gln Gly Val Glu Leu Pro Ser Ala Lys Asp Leu
                 165                 170                 175    
 Val Phe Glu Glu Ala Cys Gly Tyr Tyr Gln Arg Arg Ser Leu Arg Gly
             180                 185                 190        
 Ala Gln Leu Thr Pro Glu Glu Leu Arg His Ser Ser Thr Phe Arg Ala
         195                 200                 205            
 Pro Gln Ala Leu Ala Ser Ile Leu Gln Gly His Leu Pro Pro Ser Ala
     210                 215                 220                
 Leu Leu Thr Met Leu Arg Thr Glu Leu Arg Asp Tyr Arg Gly Leu Glu
 225                 230                 235                 240
 Gln Leu Lys Ala Gln Leu Val Ala Gly Asp Asp Glu Glu Ala Gly Trp
                 245                 250                 255    
 Thr Glu Leu Ala Glu Gln Glu Val Ala Arg Leu Leu Arg Thr Glu Leu
             260                 265                 270        
 Ile Gly Asp Gln Leu Ala Gln Leu Asn Thr Val Phe Gln Ala Leu Pro
         275                 280                 285            
 Thr Ala Ala Trp Gly Ala Thr Leu Arg Ala Leu Gln Leu Gln Leu Asp
     290                 295                 300                
 Gly Asn Gly Lys Leu Arg Ser Gln Ala Pro Pro Asp Val Trp Lys Lys
 305                 310                 315                 320
 Val Leu Gly Gly Ile Thr Ala Gly Lys Glu Pro Pro Asn Gly Ile Leu
                 325                 330                 335    
 Pro Pro Phe Glu Leu Leu Cys Gln Cys Leu Cys Gln Leu Glu Pro Arg
             340                 345                 350        
 Trp Leu Pro Pro Phe Val Glu Leu Ala Gln Gln Gln Gly Gly Pro Gly
         355                 360                 365            
 Trp Gly Ala Gly Gly Pro Gly Leu Pro Leu Tyr Arg Arg Ala Leu Ala
     370                 375                 380                
 Val Leu Gly Glu Glu Gly Thr Arg Pro Glu Ala Leu Glu Leu Glu Leu
 385                 390                 395                 400
 Leu Leu Ser Ser Gly Arg Pro Lys Ala Val Leu Gln Ala Val Gly Gln
                 405                 410                 415    
 Leu Val Gln Lys Glu Gln Trp Asp Arg Ala Leu Asp Ala Gly Leu Ala
             420                 425                 430        
 Leu Gly Pro Ser Ser Pro Leu Leu Arg Ser Glu Ile Phe Lys Leu Leu
         435                 440                 445            
 Leu Ala Glu Phe Ala Gln His Arg Arg Leu Asp Ala His Leu Pro Leu
     450                 455                 460                
 Leu Cys Arg Leu Cys Pro Pro Glu Leu Ala Pro Ala Glu Leu Leu Leu
 465                 470                 475                 480
 Leu Leu Arg Thr Tyr Leu Pro Asp Glu Val Gly Pro Pro Thr Pro Phe
                 485                 490                 495    
 Pro Glu Pro Gly Ala Glu Pro Pro Leu Thr Val Gly Leu Leu Lys Ala
             500                 505                 510        
 Leu Leu Glu Gln Thr Gly Ala Gln Gly Trp Leu Ser Gly Pro Val Leu
         515                 520                 525            
 Ser Pro Tyr Glu Asp Ile Leu Trp Asp Pro Ser Thr Pro Pro Pro Thr
     530                 535                 540                
 Pro Pro Arg Asp Leu
 545                



      <210> 610
      <211> 443
      <212> PRT
      <213> Homo sapiens


      <400> 610
 Met Asp Gly His Gly Leu Glu Lys Gln His His Ser Arg Arg Gln Pro
   1               5                  10                  15    
 Leu Pro Ala Ala Glu Val Glu Gln Arg Arg Arg Pro Gly His Leu Pro
              20                  25                  30        
 Pro Gly Cys Trp Ser Met Leu Leu Leu Leu Leu Phe Ser Leu Gly Leu
          35                  40                  45            
 Leu His Ala Gly Asp Cys Gln Gln Pro Ala Gln Cys Arg Ile Gln Lys
      50                  55                  60                
 Cys Thr Thr Asp Phe Val Ser Leu Thr Ser His Leu Asn Ser Ala Val
  65                  70                  75                  80
 Asp Gly Phe Asp Ser Glu Phe Cys Lys Ala Leu Arg Ala Tyr Ala Gly
                  85                  90                  95    
 Cys Thr Gln Arg Thr Ser Lys Ala Cys Arg Gly Asn Leu Val Tyr His
             100                 105                 110        
 Ser Ala Val Leu Gly Ile Ser Asp Leu Met Ser Gln Arg Asn Cys Ser
         115                 120                 125            
 Lys Asp Gly Pro Thr Ser Ser Thr Asn Pro Glu Val Thr His Asp Pro
     130                 135                 140                
 Cys Asn Tyr His Ser His Ala Gly Ala Arg Glu His Arg Arg Gly Asp
 145                 150                 155                 160
 Gln Asn Pro Pro Ser Tyr Leu Phe Cys Gly Leu Phe Gly Asp Pro His
                 165                 170                 175    
 Leu Arg Thr Phe Lys Asp Asn Phe Gln Thr Cys Lys Val Glu Gly Ala
             180                 185                 190        
 Trp Pro Leu Ile Asp Asn Asn Tyr Leu Ser Val Gln Val Thr Asn Val
         195                 200                 205            
 Pro Val Val Pro Gly Ser Ser Ala Thr Ala Thr Asn Lys Ile Thr Ile
     210                 215                 220                
 Ile Phe Lys Ala His His Glu Cys Thr Asp Gln Lys Val Tyr Gln Ala
 225                 230                 235                 240
 Val Thr Asp Asp Leu Pro Ala Ala Phe Val Asp Gly Thr Thr Ser Gly
                 245                 250                 255    
 Gly Asp Ser Asp Ala Lys Ser Leu Arg Ile Val Glu Arg Glu Ser Gly
             260                 265                 270        
 His Tyr Val Glu Met His Ala Arg Tyr Ile Gly Thr Thr Val Phe Val
         275                 280                 285            
 Arg Gln Val Gly Arg Tyr Leu Thr Leu Ala Ile Arg Met Pro Glu Asp
     290                 295                 300                
 Leu Ala Met Ser Tyr Glu Glu Ser Gln Asp Leu Gln Leu Cys Val Asn
 305                 310                 315                 320
 Gly Cys Pro Leu Ser Glu Arg Ile Asp Asp Gly Gln Gly Gln Val Ser
                 325                 330                 335    
 Ala Ile Leu Gly His Ser Leu Pro Arg Thr Ser Leu Val Gln Ala Trp
             340                 345                 350        
 Pro Gly Tyr Thr Leu Glu Thr Ala Asn Thr Gln Cys His Glu Lys Met
         355                 360                 365            
 Pro Val Lys Asp Ile Tyr Phe Gln Ser Cys Val Phe Asp Leu Leu Thr
     370                 375                 380                
 Thr Gly Asp Ala Asn Phe Thr Ala Ala Ala His Ser Ala Leu Glu Asp
 385                 390                 395                 400
 Val Glu Ala Leu His Pro Arg Lys Glu Arg Trp His Ile Phe Pro Ser
                 405                 410                 415    
 Ser Gly Asn Gly Thr Pro Arg Gly Gly Ser Asp Leu Ser Val Ser Leu
             420                 425                 430        
 Gly Leu Thr Cys Leu Ile Leu Ile Val Phe Leu
         435                 440            



      <210> 611
      <211> 70
      <212> PRT
      <213> Homo sapiens


      <400> 611
 Met Phe Thr Arg Ala Gln Val Arg Arg Ile Leu Gln Arg Val Pro Gly
   1               5                  10                  15    
 Lys Gln Arg Phe Gly Ile Tyr Arg Phe Leu Pro Phe Phe Phe Val Leu
              20                  25                  30        
 Gly Gly Thr Met Glu Trp Ile Met Ile Lys Val Arg Val Gly Gln Glu
          35                  40                  45            
 Thr Phe Tyr Asp Val Tyr Arg Arg Lys Ala Ser Glu Arg Gln Tyr Gln
      50                  55                  60                
 Arg Arg Leu Glu Asp Glu
  65                  70



      <210> 612
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 612
 Met Asp Asp Lys Pro Asn Pro Glu Ala Leu Ser Asp Ser Ser Glu Arg
   1               5                  10                  15    
 Leu Phe Ser Phe Gly Val Ile Ala Asp Val Gln Phe Ala Asp Leu Glu
              20                  25                  30        
 Asp Gly Phe Asn Phe Gln Gly Thr Arg Arg Arg Tyr Tyr Arg His Ser
          35                  40                  45            
 Leu Leu His Leu Gln Gly Ala Ile Glu Asp Trp Asn Asn Glu Ser Ser
      50                  55                  60                
 Met Pro Cys Cys Val Leu Gln Leu Gly Asp Ile Ile Asp Gly Tyr Asn
  65                  70                  75                  80
 Ala Gln Tyr Asn Ala Ser Lys Lys Ser Leu Glu Leu Val Met Asp Met
                  85                  90                  95    
 Phe Lys Arg Leu Lys Val Pro Val His His Thr Trp Gly Asn His Glu
             100                 105                 110        
 Phe Tyr Asn Phe Ser Arg Glu Tyr Leu Thr His Ser Lys Leu Asn Thr
         115                 120                 125            
 Lys Phe Leu Glu Asp Gln Ile Val His His Pro Glu Thr Met Pro Ser
     130                 135                 140                
 Glu Asp Tyr Tyr Ala Tyr His Phe Val Pro Phe Pro Lys Phe Arg Phe
 145                 150                 155                 160
 Ile Leu Leu Asp Ala Tyr Asp Leu Ser Val Leu Gly Val Asp Gln Ser
                 165                 170                 175    
 Ser Pro Lys Tyr Glu Gln Cys Met Lys Ile Leu Arg Glu His Asn Pro
             180                 185                 190        
 Asn Thr Glu Leu Asn Ser Pro Gln Gly Glu Leu Phe Leu
         195                 200                 205



      <210> 613
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 613
 Met Asp Met Arg Pro Ala Ala Gly Pro Cys Pro Thr Phe Arg Gly His
   1               5                  10                  15    
 Cys Pro Pro Ser Thr Ala Ala Ser Ser Arg Ser Cys Gly Ala Ala Thr
              20                  25                  30        
 Arg Ala Thr Thr Thr Pro Trp Ile Pro Ala Pro Ala Ala Arg Pro Ser
          35                  40                  45            
 Cys Trp Thr Val Arg Trp Gln Ser Ser Gly His Gly Thr Lys Arg Arg
      50                  55                  60                
 Arg His Gly Cys Pro Ser Thr Glu Gly Gly Thr Leu Gly Met Pro Leu
  65                  70                  75                  80
 Arg Pro Pro Arg Val Glu Gly Gln Gly Pro Gln Leu Gly Leu Arg Pro
                  85                  90                  95    
 Arg Pro Cys Pro Ala Arg Met Trp Pro Ser Leu Leu Arg Thr Ala Thr
             100                 105                 110        
 Arg Trp Gly Pro Gly Arg Ala Ser His Leu Ser Gln Ala Cys Pro Phe
         115                 120                 125            
 Ala Gly Pro Gln Gly Ser Trp Val Arg Ser Ser Phe His Leu Gln Pro
     130                 135                 140                
 Arg Met Ile Gly
 145            



      <210> 614
      <211> 58
      <212> PRT
      <213> Homo sapiens


      <400> 614
 Met Ile Leu Thr Glu Glu Ile Leu Gln Val Phe Thr Ala Lys Pro Lys
   1               5                  10                  15    
 Glu Met Arg Val Asn Ser Lys Trp Pro Thr Gln Arg Ser Met Asp Tyr
              20                  25                  30        
 Val Glu Thr Trp Thr Ile Ala Ala Ile Ser Gln Trp Cys Ser Phe Gln
          35                  40                  45            
 Ala Leu Tyr Pro Arg Arg Glu Lys Asn Lys
      50                  55            



      <210> 615
      <211> 531
      <212> PRT
      <213> Homo sapiens


      <400> 615
 Met Ser Leu Pro Ser Gly His Thr Thr Gly His Thr Asp Gln Val Val
   1               5                  10                  15    
 Gln Arg Arg Ala Arg Cys Trp Asp Ile Tyr Gln Arg Arg Phe Ser Ser
              20                  25                  30        
 Arg Ser Glu Pro Val Asn Pro Gly Met His Ser Ser Ser His Gln Gln
          35                  40                  45            
 Gln Asp Gly Asp Ala Ala Met His Gly Ala His Met Asp Ser Pro Val
      50                  55                  60                
 Arg Tyr Thr Pro Tyr Thr Ile Ser Pro Tyr Asn Arg Lys Gly Ser Phe
  65                  70                  75                  80
 Arg Lys Gln Asp Gln Thr His Val Asn Met Glu Arg Glu Gln Lys Pro
                  85                  90                  95    
 Pro Glu Arg Arg Met Glu Gly Asn Met Pro Asp Gly Thr Leu Gly Ser
             100                 105                 110        
 Trp Phe Lys Ile Thr Val Pro Phe Gly Ile Lys Tyr Asn Glu Lys Trp
         115                 120                 125            
 Leu Leu Asn Leu Ile Gln Asn Glu Cys Ser Val Pro Phe Val Pro Val
     130                 135                 140                
 Glu Phe His Tyr Glu Asn Met His Ala Ser Phe Phe Val Glu Asn Ala
 145                 150                 155                 160
 Ser Ile Ala Tyr Ala Leu Lys Asn Val Ser Gly Lys Ile Trp Asp Glu
                 165                 170                 175    
 Asp Asn Glu Lys Ile Ser Ile Phe Val Asn Pro Ala Gly Ile Pro His
             180                 185                 190        
 Phe Val His Arg Glu Leu Lys Ser Glu Lys Val Glu Gln Ile Lys Leu
         195                 200                 205            
 Ala Met Asn Gln Gln Cys Asp Val Ser Gln Glu Ala Leu Asp Ile Gln
     210                 215                 220                
 Arg Leu Pro Phe Tyr Pro Asp Met Val Asn Arg Asp Thr Lys Met Ala
 225                 230                 235                 240
 Ser Asn Pro Arg Lys Cys Met Ala Ala Ser Leu Asp Val His Glu Glu
                 245                 250                 255    
 Asn Ile Pro Thr Val Met Ser Ala Gly Glu Met Asp Lys Trp Lys Gly
             260                 265                 270        
 Ile Glu Pro Gly Glu Lys Cys Ala Asp Arg Ser Pro Val Cys Thr Thr
         275                 280                 285            
 Phe Ser Asp Thr Ser Ser Asn Ile Asn Ser Ile Leu Glu Leu Phe Pro
     290                 295                 300                
 Lys Leu Leu Cys Leu Asp Gly Gln Gln Ser Pro Arg Ala Thr Leu Cys
 305                 310                 315                 320
 Gly Thr Glu Ala His Lys Arg Leu Pro Thr Cys Lys Gly Ser Phe Phe
                 325                 330                 335    
 Gly Ser Glu Met Leu Lys Asn Leu Val Leu Gln Phe Leu Gln Gln Tyr
             340                 345                 350        
 Tyr Leu Ile Tyr Asp Ser Gly Asp Arg Gln Gly Leu Leu Ser Ala Tyr
         355                 360                 365            
 His Asp Glu Ala Cys Phe Ser Leu Ser Ile Pro Phe Asn Pro Glu Asp
     370                 375                 380                
 Ser Ala Pro Ser Ser Phe Cys Lys Phe Phe Lys Asp Ser Arg Asn Ile
 385                 390                 395                 400
 Lys Ile Leu Lys Asp Pro Tyr Leu Arg Gly Glu Leu Leu Lys His Thr
                 405                 410                 415    
 Lys Leu Asp Ile Val Asp Ser Leu Ser Ala Leu Pro Lys Thr Gln His
             420                 425                 430        
 Asp Leu Ser Ser Phe Leu Val Asp Met Trp Tyr Gln Thr Glu Trp Met
         435                 440                 445            
 Leu Cys Phe Ser Val Asn Gly Val Phe Lys Glu Val Glu Gly Gln Ser
     450                 455                 460                
 Gln Gly Ser Val Leu Ala Phe Thr Arg Thr Phe Ile Ala Thr Pro Gly
 465                 470                 475                 480
 Ser Ser Ser Ser Leu Cys Ile Val Asn Asp Lys Leu Phe Val Arg Asp
                 485                 490                 495    
 Thr Ser His Gln Gly Thr Gln Ser Ala Leu Phe Thr Leu Val Pro Thr
             500                 505                 510        
 Ala Phe Ser Ser Ser Val Pro Ala Phe Ser Gln Glu Gln Gln Lys Met
         515                 520                 525            
 Leu Pro Ser
     530    



      <210> 616
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 616
 Met Leu Gly Gly Gly Met Lys Leu Lys Asn Lys Ser Thr Asp Phe Thr
   1               5                  10                  15    
 Lys Leu Leu Ser Arg Gly Ala Thr Ile Tyr Ser Lys Gln Leu Phe Pro
              20                  25                  30        
 Pro Ser Leu Thr His Thr Pro Thr Phe Thr Gly Ala Thr Ile Leu Leu
          35                  40                  45            
 Ile Ile Tyr Pro Cys Ile Gln His Ser Leu Asn Lys Val Gly Pro Asn
      50                  55                  60                
 Pro Glu Arg Ala Pro Lys Tyr Tyr Pro Arg Tyr Thr Leu Tyr Gly Arg
  65                  70                  75                  80
 Ala Leu Ser Thr Ser Pro Phe Leu Lys Glu Arg Lys Ile Arg Pro Ile
                  85                  90                  95    
 Ser Gln Thr Lys Glu Thr Arg Ser Ser Gln Gln Glu Lys Arg Arg Glu
             100                 105                 110        
 Arg Gln Lys Asp Pro Thr Leu Thr His Lys Asn Asp Ser His
         115                 120                 125    



      <210> 617
      <211> 73
      <212> PRT
      <213> Homo sapiens


      <400> 617
 Met Leu Gln Ile Trp Val Thr Leu Asn Asn Glu Asn Leu Val Phe Lys
   1               5                  10                  15    
 Glu Asn Val Gly Arg Ser Pro Gln Ile Thr His Leu Leu Cys Leu Met
              20                  25                  30        
 Leu Ile Asn Cys Ile Phe Ser Leu Leu Leu Leu Leu Ser His Ala Asp
          35                  40                  45            
 Gly Met His Leu Phe Ile Ser Ser Gly Asp Arg Ile Leu Phe Cys Leu
      50                  55                  60                
 Tyr Phe Leu His Ser Arg Val Cys Ala
  65                  70            



      <210> 618
      <211> 398
      <212> PRT
      <213> Homo sapiens


      <400> 618
 Met Glu Ser Val Leu Ser Lys Tyr Glu Asp Gln Ile Thr Ile Phe Thr
   1               5                  10                  15    
 Asp Tyr Leu Glu Glu Tyr Pro Asp Thr Asp Glu Leu Val Trp Ile Leu
              20                  25                  30        
 Gly Lys Gln His Leu Leu Lys Thr Glu Lys Ser Lys Leu Leu Ser Asp
          35                  40                  45            
 Ile Ser Ala Arg Leu Trp Phe Thr Tyr Arg Arg Lys Phe Ser Pro Ile
      50                  55                  60                
 Gly Gly Thr Gly Pro Ser Ser Asp Ala Gly Trp Gly Cys Met Leu Arg
  65                  70                  75                  80
 Cys Gly Gln Met Met Leu Ala Gln Ala Leu Ile Cys Arg His Leu Gly
                  85                  90                  95    
 Arg Asp Trp Ser Trp Glu Lys Gln Lys Glu Gln Pro Lys Glu Tyr Gln
             100                 105                 110        
 Arg Ile Leu Gln Cys Phe Leu Asp Arg Lys Asp Cys Cys Tyr Ser Ile
         115                 120                 125            
 His Gln Met Ala Gln Met Gly Val Gly Glu Gly Lys Ser Ile Gly Glu
     130                 135                 140                
 Trp Phe Gly Pro Asn Thr Val Ala Gln Val Leu Lys Lys Leu Ala Leu
 145                 150                 155                 160
 Phe Asp Glu Trp Asn Ser Leu Ala Val Tyr Val Ser Met Asp Asn Thr
                 165                 170                 175    
 Val Val Ile Glu Asp Ile Lys Lys Met Cys Arg Val Leu Pro Leu Ser
             180                 185                 190        
 Ala Asp Thr Ala Gly Asp Arg Pro Pro Asp Ser Leu Thr Ala Ser Asn
         195                 200                 205            
 Gln Ser Lys Gly Thr Ser Ala Tyr Cys Ser Ala Trp Lys Pro Leu Leu
     210                 215                 220                
 Leu Ile Val Pro Leu Arg Leu Gly Ile Asn Gln Ile Asn Pro Val Tyr
 225                 230                 235                 240
 Val Asp Ala Phe Lys Glu Cys Phe Lys Met Pro Gln Ser Leu Gly Ala
                 245                 250                 255    
 Leu Gly Gly Lys Pro Asn Asn Ala Tyr Tyr Phe Ile Gly Phe Leu Gly
             260                 265                 270        
 Asp Glu Leu Ile Phe Leu Asp Pro His Thr Thr Gln Thr Phe Val Asp
         275                 280                 285            
 Thr Glu Glu Asn Gly Thr Val Asn Asp Gln Thr Phe His Cys Leu Gln
     290                 295                 300                
 Ser Pro Gln Arg Met Asn Ile Leu Asn Leu Asp Pro Ser Val Ala Leu
 305                 310                 315                 320
 Gly Phe Phe Cys Lys Glu Glu Lys Asp Phe Asp Asn Trp Cys Ser Leu
                 325                 330                 335    
 Val Gln Lys Glu Ile Leu Lys Glu Asn Leu Arg Met Phe Glu Leu Val
             340                 345                 350        
 Gln Lys His Pro Ser His Trp Pro Pro Phe Val Pro Pro Ala Lys Pro
         355                 360                 365            
 Glu Val Thr Thr Thr Gly Ala Glu Phe Ile Asp Ser Thr Glu Gln Leu
     370                 375                 380                
 Glu Glu Phe Asp Leu Glu Glu Asp Phe Glu Ile Leu Ser Val
 385                 390                 395            



      <210> 619
      <211> 238
      <212> PRT
      <213> Homo sapiens


      <400> 619
 Met Gly Phe Cys Ala Thr Gly Met Gln Arg Lys Gly Arg Gly Leu Gly
   1               5                  10                  15    
 Lys Thr Ser Pro Lys Lys Gln His Leu Asn Leu Pro Leu Arg Glu Lys
              20                  25                  30        
 Glu Val Gly Leu Ser Cys His Val Gly Asn Gly Ser Thr Val Glu Gly
          35                  40                  45            
 Gly His Phe Gly Ala Phe Ala His Ile Arg Val Asn Leu Asn Ser Leu
      50                  55                  60                
 Ser Pro His Ile Ser Val Phe Pro Val Thr Tyr Cys Tyr Ala Asp Cys
  65                  70                  75                  80
 Ser Ser Lys Pro Gln Ile Leu Ser Gln Leu Phe Arg Arg Gln Arg Gly
                  85                  90                  95    
 Pro Gln Ala Gly Leu Ser Pro Gln Gly Val Leu Ser Asp Val Asp Thr
             100                 105                 110        
 Thr Gly Val Gln Ala Pro Pro Cys Arg Arg Ala Pro Leu Met Glu Thr
         115                 120                 125            
 Cys Val Arg Pro Gly Arg Pro Thr Ala Gly Val Val Ile Gln Gly Gly
     130                 135                 140                
 Asn Gly Ile Gly Arg Ser Leu Pro Ser Gly Lys Asp Ala Gly Val Gly
 145                 150                 155                 160
 Asn Arg Cys Ser Arg Asn Arg Arg Ser Glu Arg Gly Thr Gly Val Thr
                 165                 170                 175    
 Arg Gly Ala Ser Glu His Gln Gln Leu Arg Gly Ala Arg Gly Ser Arg
             180                 185                 190        
 Asp Val Gln Ala Thr Glu Gly Ile Gly Ser Leu Pro Ser Val Ala Met
         195                 200                 205            
 Thr Val His Pro Thr Ala Cys Pro Pro Leu Leu Arg Ala Val Leu Ala
     210                 215                 220                
 Gln Ala Val Ala Gly Phe Ser Ser Ser Ile Met Trp Pro Gly
 225                 230                 235            



      <210> 620
      <211> 285
      <212> PRT
      <213> Homo sapiens


      <400> 620
 Met Glu Phe Tyr Thr Lys Glu Gly Glu Pro Tyr Leu Arg Thr Ala His
   1               5                  10                  15    
 Gly Val Phe Ile Cys Tyr Trp Asp Gly Thr Val His Tyr Leu Leu Tyr
              20                  25                  30        
 Leu Ala Met Ala Gly Ala Ile Cys Arg Arg Lys Arg Tyr Arg Asn Phe
          35                  40                  45            
 Gly Leu Tyr Trp Leu Gly Ser Phe Ala Met Ser Ile Leu Val Phe Leu
      50                  55                  60                
 Thr Gly Asn Ile Leu Gly Lys Tyr Ser Ser Glu Ile Arg Pro Ala Phe
  65                  70                  75                  80
 Phe Leu Thr Ile Pro Tyr Leu Leu Val Pro Cys Trp Ala Gly Met Lys
                  85                  90                  95    
 Val Phe Ser Gln Pro Arg Ala Leu Thr Arg Cys Thr Ala Asn Met Val
             100                 105                 110        
 Gln Glu Glu Gln Arg Lys Gly Leu Leu Gln Arg Pro Ala Asp Leu Ala
         115                 120                 125            
 Leu Val Ile Tyr Leu Ile Leu Ala Gly Phe Phe Thr Leu Phe Arg Gly
     130                 135                 140                
 Leu Val Val Leu Asp Cys Pro Thr Asp Ala Cys Phe Val Tyr Ile Tyr
 145                 150                 155                 160
 Gln Tyr Glu Pro Tyr Leu Arg Asp Pro Val Ala Tyr Pro Lys Val Gln
                 165                 170                 175    
 Met Leu Met Tyr Met Phe Tyr Val Leu Pro Phe Cys Gly Leu Ala Ala
             180                 185                 190        
 Tyr Ala Leu Thr Phe Pro Gly Cys Ser Trp Leu Pro Asp Trp Ala Leu
         195                 200                 205            
 Val Phe Ala Gly Gly Ile Gly Gln Ala Gln Phe Ser His Met Gly Ala
     210                 215                 220                
 Ser Met His Leu Arg Thr Pro Phe Thr Tyr Arg Val Pro Glu Asp Thr
 225                 230                 235                 240
 Trp Gly Cys Phe Phe Val Cys Asn Leu Leu Tyr Ala Leu Gly Pro His
                 245                 250                 255    
 Leu Leu Ala Tyr Arg Cys Leu Gln Trp Pro Ala Phe Phe His Gln Pro
             260                 265                 270        
 Pro Pro Ser Asp Pro Leu Ala Leu His Lys Lys Gln His
         275                 280                 285



      <210> 621
      <211> 1188
      <212> PRT
      <213> Homo sapiens


      <400> 621
 Met Arg Asp Gly Ser Asp Gly Ala Ala Leu Leu Ala Val Ile His Tyr
   1               5                  10                  15    
 Tyr Cys Pro Glu Gln Met Lys Leu Asp Asp Ile Cys Leu Lys Glu Val
              20                  25                  30        
 Thr Ser Met Ala Asp Ser Leu Tyr Asn Ile Arg Leu Leu Arg Glu Phe
          35                  40                  45            
 Ser Asn Glu Tyr Leu Asn Lys Cys Phe Tyr Leu Thr Leu Glu Asp Met
      50                  55                  60                
 Leu Tyr Ala Pro Leu Val Leu Lys Pro Asn Val Met Val Phe Ile Ala
  65                  70                  75                  80
 Glu Leu Phe Trp Trp Phe Glu Asn Val Lys Pro Asp Phe Val Gln Pro
                  85                  90                  95    
 Arg Asp Val Gln Glu Leu Lys Asp Ala Lys Thr Val Leu His Gln Lys
             100                 105                 110        
 Ser Ser Arg Pro Pro Val Pro Ile Ser Asn Ala Thr Lys Arg Ser Phe
         115                 120                 125            
 Leu Gly Ser Pro Ala Ala Gly Thr Leu Ala Glu Leu Gln Pro Pro Val
     130                 135                 140                
 Gln Leu Pro Ala Glu Gly Cys His Arg His Tyr Leu His Pro Glu Glu
 145                 150                 155                 160
 Pro Glu Tyr Leu Gly Lys Gly Thr Ala Ala Phe Ser Pro Ser His Pro
                 165                 170                 175    
 Leu Leu Pro Leu Arg Gln Lys Gln Gln Lys Ser Ile Gln Gly Glu Asp
             180                 185                 190        
 Ile Pro Asp Gln Arg His Arg Ser Asn Ser Leu Thr Arg Val Asp Gly
         195                 200                 205            
 Gln Pro Arg Gly Ala Ala Ile Ala Trp Pro Glu Lys Lys Thr Arg Pro
     210                 215                 220                
 Ala Ser Gln Pro Thr Pro Phe Ala Leu His His Ala Ala Ser Cys Glu
 225                 230                 235                 240
 Val Asp Pro Ser Ser Gly Asp Ser Ile Ser Leu Ala Arg Ser Ile Ser
                 245                 250                 255    
 Lys Asp Ser Leu Ala Ser Asn Ile Val Asn Leu Thr Pro Gln Asn Gln
             260                 265                 270        
 Pro His Pro Thr Ala Thr Lys Ser His Gly Lys Ser Leu Leu Ser Asn
         275                 280                 285            
 Val Ser Ile Glu Asp Glu Glu Glu Glu Leu Val Ala Ile Val Arg Ala
     290                 295                 300                
 Asp Val Val Pro Gln Gln Ala Asp Pro Glu Phe Pro Arg Ala Ser Pro
 305                 310                 315                 320
 Arg Ala Leu Gly Leu Thr Ala Asn Ala Arg Ser Pro Gln Gly Gln Leu
                 325                 330                 335    
 Asp Thr Ser Glu Ser Lys Pro Asp Ser Phe Phe Leu Glu Pro Leu Met
             340                 345                 350        
 Pro Ala Val Leu Lys Pro Ala Lys Glu Lys Gln Val Ile Thr Lys Glu
         355                 360                 365            
 Asp Glu Arg Gly Glu Gly Arg Pro Arg Ser Ile Val Ser Arg Arg Pro
     370                 375                 380                
 Ser Glu Gly Pro Gln Pro Leu Val Arg Arg Lys Met Thr Gly Ser Arg
 385                 390                 395                 400
 Asp Leu Asn Arg Thr Phe Thr Pro Ile Pro Cys Ser Glu Phe Pro Met
                 405                 410                 415    
 Gly Ile Asp Pro Thr Glu Thr Gly Pro Leu Ser Val Glu Thr Ala Gly
             420                 425                 430        
 Glu Val Cys Gly Gly Pro Leu Ala Leu Gly Gly Phe Asp Pro Phe Pro
         435                 440                 445            
 Gln Gly Pro Ser Thr Asp Gly Phe Phe Leu His Val Gly Arg Ala Asp
     450                 455                 460                
 Glu Asp Thr Glu Gly Arg Leu Tyr Val Ser Cys Ser Lys Ser Pro Asn
 465                 470                 475                 480
 Ser His Asp Ser Glu Pro Trp Thr Leu Leu Arg Gln Asp Ser Asp Ser
                 485                 490                 495    
 Asp Val Val Asp Ile Glu Glu Ala Glu His Asp Phe Met Gly Glu Ala
             500                 505                 510        
 His Pro Val Val Phe Ser Arg Tyr Ile Gly Glu Glu Glu Ser Ala Lys
         515                 520                 525            
 Leu Gln Glu Asp Met Lys Val Lys Glu His Glu Asp Lys Asp Asp Ala
     530                 535                 540                
 Ser Gly Arg Ser Ser Pro Cys Leu Ser Thr Ala Ser Gln Met Ser Ser
 545                 550                 555                 560
 Val Ser Met Ala Ser Gly Ser Val Lys Met Thr Ser Phe Ala Glu Arg
                 565                 570                 575    
 Lys Leu Gln Arg Leu Asn Ser Cys Glu Thr Lys Ser Ser Thr Ser Ser
             580                 585                 590        
 Ser Gln Lys Thr Thr Pro Asp Ala Ser Glu Ser Cys Pro Ala Pro Leu
         595                 600                 605            
 Thr Thr Trp Arg Gln Lys Arg Glu Gln Ser Pro Ser Gln His Gly Lys
     610                 615                 620                
 Asp Pro Ala Ser Leu Leu Ala Ser Glu Leu Val Gln Leu His Met Gln
 625                 630                 635                 640
 Leu Glu Glu Lys Arg Arg Ala Ile Glu Ala Gln Lys Lys Lys Met Glu
                 645                 650                 655    
 Ala Leu Ser Ala Arg Gln Arg Leu Lys Leu Gly Lys Ala Ala Phe Leu
             660                 665                 670        
 His Val Val Lys Lys Gly Lys Ala Glu Ala Ala Pro Pro Leu Arg Pro
         675                 680                 685            
 Glu His Phe Ala Lys Glu Tyr Ser Gln His Asn Gly Glu Asp Cys Gly
     690                 695                 700                
 Asp Ala Val Ser Lys Thr Glu Asp Phe Leu Val Lys Glu Glu Gln Arg
 705                 710                 715                 720
 Glu Glu Leu Leu His Glu Pro Gln Asp Val Asp Lys Glu Ser Leu Ala
                 725                 730                 735    
 Phe Ala Gln Gln His Lys Ala Lys Asp Pro Val Ala Leu His Glu Leu
             740                 745                 750        
 Glu Arg Asn Lys Val Ile Ser Ala Ala Leu Leu Glu Asp Thr Val Gly
         755                 760                 765            
 Glu Val Val Asp Val Asn Glu Cys Asp Leu Ser Ile Glu Lys Leu Asn
     770                 775                 780                
 Glu Thr Ile Ser Thr Leu Gln Gln Ala Ile Leu Lys Ile Ser Gln Gln
 785                 790                 795                 800
 Gln Glu Gln Leu Leu Met Lys Ser Pro Thr Val Pro Val Pro Gly Ser
                 805                 810                 815    
 Lys Asn Asn Ser Gln Asp His Lys Val Lys Ala Pro Val His Phe Val
             820                 825                 830        
 Glu Pro Leu Ser Pro Thr Gly Val Ala Gly His Arg Lys Ala Pro Arg
         835                 840                 845            
 Leu Gly Gln Gly Arg Asn Ser Arg Ser Gly Arg Pro Ala Glu Leu Lys
     850                 855                 860                
 Val Pro Lys Asp Arg Pro Gln Gly Ser Ser Arg Ser Lys Thr Pro Thr
 865                 870                 875                 880
 Pro Ser Val Glu Thr Leu Pro His Leu Arg Pro Phe Pro Ala Ser Ser
                 885                 890                 895    
 His Pro Arg Thr Pro Thr Asp Pro Gly Leu Asp Ser Ala Leu Glu Pro
             900                 905                 910        
 Ser Gly Asp Pro His Gly Lys Cys Leu Phe Asp Ser Tyr Arg Leu His
         915                 920                 925            
 Asp Glu Ser Asn Gln Arg Thr Leu Thr Leu Ser Ser Ser Lys Asp Ala
     930                 935                 940                
 Asn Ile Leu Ser Glu Gln Met Ser Leu Lys Glu Val Leu Asp Ala Ser
 945                 950                 955                 960
 Val Lys Glu Val Gly Ser Ser Ser Ser Asp Val Ser Gly Lys Glu Ser
                 965                 970                 975    
 Val Pro Val Glu Glu Pro Leu Arg Ser Arg Ala Ser Leu Ile Glu Val
             980                 985                 990        
 Asp Leu Ser Asp Leu Lys Ala Pro Asp Glu Asp Gly Glu Leu Val Ser
         995                1000                1005            
 Leu Asp Gly Ser Ala Asp Leu Val Ser Glu Gly Asp Gln Lys Pro Gly
    1010                1015                1020                
 Val Gly Phe Phe Phe Lys Asp Glu Gln Lys Ala Glu Asp Glu Leu Ala
1025                1030                1035                1040
 Lys Lys Arg Ala Ala Phe Leu Leu Lys Gln Gln Arg Lys Ala Glu Glu
                1045                1050                1055    
 Ala Arg Val Arg Lys Gln Gln Leu Leu Met Lys Ser Pro Thr Val Pro
            1060                1065                1070        
 Val Pro Gly Ser Lys Asn Asn Ser Gln Asp His Lys Val Lys Ala Pro
        1075                1080                1085            
 Val His Phe Val Glu Pro Leu Ser Pro Thr Gly Val Ala Gly His Arg
    1090                1095                1100                
 Lys Ala Pro Arg Leu Gly Gln Gly Arg Asn Ser Arg Ser Gly Arg Pro
1105                1110                1115                1120
 Ala Glu Leu Lys Val Pro Lys Asp Arg Pro Gln Gly Ser Ser Arg Ser
                1125                1130                1135    
 Lys Thr Pro Thr Pro Ser Val Glu Thr Leu Pro His Leu Arg Pro Phe
            1140                1145                1150        
 Pro Ala Asn Ser His Pro Trp Thr Pro Thr Asp Pro Gly Leu Asp Ser
        1155                1160                1165            
 Ala Leu Glu Pro Asn Gly Asp Pro His Trp Lys Val Phe Phe Arg Gln
    1170                1175                1180                
 Leu Pro Ala Ser
1185            



      <210> 622
      <211> 210
      <212> PRT
      <213> Homo sapiens


      <400> 622
 Met Thr Gly Asn Met Val Arg Ser Gly Asn Lys Ala Ala Val Val Leu
   1               5                  10                  15    
 Cys Met Asp Val Gly Phe Thr Met Ser Asn Ser Ile Pro Gly Ile Glu
              20                  25                  30        
 Ser Pro Phe Glu Gln Ala Lys Lys Val Ile Thr Met Phe Val Gln Arg
          35                  40                  45            
 Gln Val Phe Ala Glu Asn Lys Asp Glu Ile Ala Leu Val Leu Phe Gly
      50                  55                  60                
 Thr Asp Gly Thr Asp Asn Pro Leu Ser Gly Gly Asp Gln Tyr Gln Asn
  65                  70                  75                  80
 Ile Thr Val His Arg His Leu Met Leu Pro Asp Phe Asp Leu Leu Glu
                  85                  90                  95    
 Asp Ile Glu Ser Lys Ile Gln Pro Gly Ser Gln Gln Ala Asp Phe Leu
             100                 105                 110        
 Asp Ala Leu Ile Val Ser Met Asp Val Ile Gln His Glu Thr Ile Gly
         115                 120                 125            
 Lys Lys Phe Glu Lys Arg His Ile Glu Ile Phe Thr Asp Leu Ser Ser
     130                 135                 140                
 Arg Phe Ser Lys Ser Gln Leu Asp Ile Ile Ile His Ser Leu Lys Lys
 145                 150                 155                 160
 Cys Asp Ile Ser Leu Gln Phe Phe Leu Pro Phe Ser Leu Gly Lys Glu
                 165                 170                 175    
 Asp Gly Ser Gly Asp Thr Arg Arg Trp Pro Leu Ser Leu Arg Trp Pro
             180                 185                 190        
 Trp Ala Leu Pro Phe Pro Leu Lys Gly Ile Thr Arg Thr Ala Lys Arg
         195                 200                 205            
 Arg Ser
     210



      <210> 623
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 623
 Met Gly Ala Thr Glu Val Gly Asp Glu Asn Ala Gly Thr Val Ser Ala
   1               5                  10                  15    
 Gln Pro Cys Ser Arg Gln Cys Cys Leu Glu Asp Phe Trp Ala Phe Leu
              20                  25                  30        
 Arg Gly His Pro Ala Pro Glu Pro Pro Pro Trp Thr Pro Val Leu Tyr
          35                  40                  45            
 Pro Leu Arg Thr Ser Leu Pro Phe Thr Leu Ala Val Phe Leu Asn Leu
      50                  55                  60                
 Gly Leu Ser Phe Pro Lys Thr Ser Ile Thr Ser Ser Trp Arg Asp Trp
  65                  70                  75                  80
 Thr Leu His Phe Pro Phe Ala Trp Ser Leu Ser Val Lys Gly Pro Ala
                  85                  90                  95    
 Asn Gly Cys Met Ser Lys Val Val Gly Thr Thr Ser Lys Lys Lys Gly
             100                 105                 110        
 Gly Asp Glu Ile Asn Lys
         115            



      <210> 624
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 624
 Met Lys Met Ala Asn Ser Leu Arg Gly Glu Val Leu Lys Leu Tyr Lys
   1               5                  10                  15    
 Asn Leu Leu Tyr Leu Gly Arg Asp Tyr Pro Lys Gly Ala Asp Tyr Phe
              20                  25                  30        
 Lys Lys Arg Leu Lys Asn Ile Phe Leu Lys Asn Lys Asp Val Lys Asn
          35                  40                  45            
 Pro Glu Lys Ile Lys Glu Leu Ile Ala Gln Gly Glu Phe Val Met Lys
      50                  55                  60                
 Glu Leu Glu Ala Leu Tyr Phe Leu Arg Lys Tyr Arg Ala Met Lys Gln
  65                  70                  75                  80
 Arg Tyr Tyr Ser Asp Thr Asn Lys Thr Asn
                  85                  90



      <210> 625
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 625
 Met Glu Arg Cys Asn Ser Ser Thr Leu Leu Gly Asn Cys Ile Lys Ala
   1               5                  10                  15    
 Val Leu Pro Cys Ile Ile Cys Lys Tyr Leu Leu Arg Gln Asn Thr Ser
              20                  25                  30        
 Lys Asp Thr Tyr Glu Met Tyr Thr Tyr Phe Phe Leu His Val Thr Lys
          35                  40                  45            
 Lys Ile Leu Asn Cys Ile Thr Arg Met Phe Asp Lys Leu Phe Phe Phe
      50                  55                  60                
 Lys Cys Ile Ser Phe Phe His Glu Thr Leu Lys Pro Leu Ile Ala His
  65                  70                  75                  80
 Phe Thr Leu Ser
                



      <210> 626
      <211> 172
      <212> PRT
      <213> Homo sapiens


      <400> 626
 Met Glu Glu His Leu Ser Val Met Tyr Glu Arg Leu Arg Gln Glu Leu
   1               5                  10                  15    
 Pro Lys Leu Phe Leu Gln Ser His Asp Tyr Ser Leu Tyr Ser Leu Asp
              20                  25                  30        
 Val Glu Phe Ile Asn Glu Ile Leu Asn Ile Arg Thr Lys Gly Arg Thr
          35                  40                  45            
 Trp Tyr Ile Leu Ser Leu Thr Leu Cys Arg Phe Leu Ala Trp Asn Tyr
      50                  55                  60                
 Phe Ala His Leu Arg Leu Glu Val Leu Gln Leu Thr Arg His Pro Glu
  65                  70                  75                  80
 Asn Trp Thr Leu Gln Ala Arg Trp Arg Leu Val Gly Leu Pro Val His
                  85                  90                  95    
 Leu Leu Phe Leu Arg Phe Tyr Lys Arg Asp Lys Asp Glu His Tyr Arg
             100                 105                 110        
 Thr Tyr Asp Ala Tyr Ser Thr Phe Tyr Leu Asn Ser Ser Gly Leu Ile
         115                 120                 125            
 Cys Arg His Arg Leu Asp Lys Leu Met Pro Ser His Ser Pro Pro Thr
     130                 135                 140                
 Pro Val Lys Lys Leu Leu Val Gly Ala Leu Val Ala Leu Gly Leu Ser
 145                 150                 155                 160
 Glu Pro Glu Pro Asp Leu Asn Leu Cys Ser Lys Pro
                 165                 170        



      <210> 627
      <211> 154
      <212> PRT
      <213> Homo sapiens


      <400> 627
 Met Ser Ala Thr Arg Ala Lys Lys Val Lys Met Ala Thr Lys Ser Cys
   1               5                  10                  15    
 Pro Glu Cys Asp Gln Gln Val Pro Val Ala Cys Lys Ser Cys Pro Cys
              20                  25                  30        
 Gly Tyr Ile Phe Ile Ser Arg Lys Leu Leu Asn Ala Lys His Ser Glu
          35                  40                  45            
 Lys Ser Pro Pro Ser Thr Glu Asn Lys His Glu Ala Lys Arg Arg Arg
      50                  55                  60                
 Thr Glu Arg Val Arg Arg Glu Lys Ile Asn Ser Thr Val Asn Lys Asp
  65                  70                  75                  80
 Leu Glu Asn Arg Lys Arg Ser Arg Ser Asn Ser His Ser Asp His Ile
                  85                  90                  95    
 Arg Arg Gly Arg Gly Arg Pro Lys Ser Ala Ser Ala Lys Lys His Glu
             100                 105                 110        
 Glu Glu Arg Glu Lys Gln Glu Lys Glu Ile Asp Ile Tyr Ala Asn Leu
         115                 120                 125            
 Ser Asp Glu Lys Ala Phe Val Phe Ser Val Ala Leu Ala Glu Ile Asn
     130                 135                 140                
 Arg Lys Ile Ile Asn Gln Arg Leu Ile Leu
 145                 150                



      <210> 628
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 628
 Met Thr Asp Arg Asn Arg Asp Lys Lys Ser Thr Ser Pro Ser Asn Ser
   1               5                  10                  15    
 Asp Thr Glu Met Lys Ser Glu Gln Leu Pro Pro Cys Val Asn Pro Gly
              20                  25                  30        
 Asn Pro Val Phe Ser Cys Met Leu Asp Pro Lys Thr Leu Gln Thr Ala
          35                  40                  45            
 Thr Ser Leu Ser Lys Pro Gln Met Ile Met Tyr Lys Thr Asn Ser Ser
      50                  55                  60                
 His Tyr Gly Glu Phe Leu Pro Ile Pro Gln Phe Phe Pro Cys Asn Tyr
  65                  70                  75                  80
 Thr Pro Lys Glu Gln Val Phe Ser Ser His Ile Arg Ala Thr Gly Phe
                  85                  90                  95    
 Tyr Gln Asn Asn Thr Leu Asn Thr Ala Pro Asp Arg Thr Arg Thr Leu
             100                 105                 110        
 Asp Phe Pro Asn Ile Gln His Thr Leu
         115                 120    



      <210> 629
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 629
 Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp
   1               5                  10                  15    
 Glu Arg Ala Asp Ala Lys Thr Leu Arg Lys Ala Met Lys Gly Leu Gly
              20                  25                  30        
 Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala
          35                  40                  45            
 Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp
      50                  55                  60                
 Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu
  65                  70                  75                  80
 Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu
                  85                  90                  95    
 Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu
             100                 105                 110        
 Ile Ile Ala Ser Gly
         115        



      <210> 630
      <211> 35
      <212> PRT
      <213> Homo sapiens


      <400> 630
 Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp
   1               5                  10                  15    
 Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly
              20                  25                  30        
 Ser Ser Gly
          35



      <210> 631
      <211> 634
      <212> PRT
      <213> Homo sapiens


      <400> 631
 Met Gly Glu Asn Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe
   1               5                  10                  15    
 Ser Cys Ile Leu Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu
              20                  25                  30        
 Gln Cys Pro Thr Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro
          35                  40                  45            
 Trp Thr Val Gly Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe
      50                  55                  60                
 Tyr Thr Lys Asn Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met
  65                  70                  75                  80
 Thr Val Ile Thr Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu
                  85                  90                  95    
 Pro Ser Ala Pro Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Ile Thr
             100                 105                 110        
 Pro Pro Ala Leu Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly
         115                 120                 125            
 Ile Ser Gly Leu Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys
     130                 135                 140                
 Ile Phe Glu Asp Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu
 145                 150                 155                 160
 Gly Val Ala Leu Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu
                 165                 170                 175    
 Val Ala Gly Pro Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val
             180                 185                 190        
 Leu Ala Tyr Gly Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg
         195                 200                 205            
 Asp Lys Gly Ala Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser
     210                 215                 220                
 Ala Tyr Gln Ser Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu
 225                 230                 235                 240
 Ala Val Leu Glu Ala Ile Leu Leu Leu Val Leu Ile Phe Leu Arg Gln
                 245                 250                 255    
 Arg Ile Arg Ile Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val
             260                 265                 270        
 Gly Gln Met Met Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu
         275                 280                 285            
 Leu Leu Ile Cys Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala
     290                 295                 300                
 Thr Ser Gly Gln Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser
 305                 310                 315                 320
 Pro Gly Cys Glu Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala
                 325                 330                 335    
 His Leu Val Asn Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly
             340                 345                 350        
 Tyr Ser Ser Lys Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile
         355                 360                 365            
 Tyr Gly Val Leu Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu
     370                 375                 380                
 Gly Gln Cys Val Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe
 385                 390                 395                 400
 His Lys Pro Gln Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile
                 405                 410                 415    
 Arg Thr Leu Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile
             420                 425                 430        
 Leu Thr Leu Val Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His
         435                 440                 445            
 Lys Leu Arg Gly Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys
     450                 455                 460                
 Phe Lys Cys Cys Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn
 465                 470                 475                 480
 Arg Asn Ala Tyr Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val
                 485                 490                 495    
 Ser Ala Lys Asn Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val
             500                 505                 510        
 Val Val Leu Asp Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu
         515                 520                 525            
 Leu Val Val Gly Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly
     530                 535                 540                
 Arg Ile Pro Gly Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr
 545                 550                 555                 560
 Tyr Trp Leu Pro Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala
                 565                 570                 575    
 Ser Gly Phe Phe Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu
             580                 585                 590        
 Cys Phe Leu Glu Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro
         595                 600                 605            
 Tyr Tyr Met Ser Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu
     610                 615                 620                
 Ala Pro Pro Asp Asn Lys Lys Arg Lys Lys
 625                 630                



      <210> 632
      <211> 55
      <212> PRT
      <213> Homo sapiens


      <400> 632
 Met Ala Ala Ser Ser Ser Ser Ser Ser Ala Gly Gly Val Ser Gly Ser
   1               5                  10                  15    
 Ser Val Thr Gly Ser Gly Phe Ser Val Ser Asp Leu Ala Pro Pro Arg
              20                  25                  30        
 Lys Ala Leu Phe Thr Tyr Pro Lys Gly Ala Gly Glu Met Leu Glu Gly
          35                  40                  45            
 Asp Leu Met Leu Leu Ser Glu
      50                  55



      <210> 633
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 633
 Met Glu His Tyr Arg Lys Ala Gly Ser Val Glu Leu Pro Ala Pro Ser
   1               5                  10                  15    
 Pro Met Pro Gln Leu Pro Pro Asp Thr Leu Glu Met Arg Val Arg Asp
              20                  25                  30        
 Gly Ser Lys Ile Arg Asn Leu Leu Gly Leu Ala Leu Gly Arg Leu Glu
          35                  40                  45            
 Gly Gly Ser Ala Arg His Val Val Phe Ser Gly Ser Gly Arg Ala Ala
      50                  55                  60                
 Gly Lys Ala Val Ser Cys Ala Glu Ile Val Lys Arg Arg Val Pro Gly
  65                  70                  75                  80
 Leu His Gln Leu Thr Lys Leu Arg Phe Leu Gln Thr Glu Asp Ser Trp
                  85                  90                  95    
 Val Pro Ala Ser Pro Asp Thr Gly Leu Asp Pro Leu Thr Val Arg Arg
             100                 105                 110        
 His Val Pro Ala Val Trp Val Leu Leu Ser Arg Asp Pro Leu Asp Pro
         115                 120                 125            
 Asn Glu Cys Gly Tyr Gln Pro Pro Gly Ala Pro Pro Gly Leu Gly Ser
     130                 135                 140                
 Met Pro Ser Ser Ser Cys Gly Pro Arg Ser Arg Arg Arg Ala Arg Asp
 145                 150                 155                 160
 Thr Arg Ser
            



      <210> 634
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 634
 Met Ser Glu Ala Tyr Phe Arg Val Glu Ser Gly Ala Leu Gly Pro Glu
   1               5                  10                  15    
 Glu Asn Phe Leu Ser Leu Asp Asp Ile Leu Met Ser His Glu Lys Leu
              20                  25                  30        
 Pro Val Arg Thr Glu Thr Ala Met Pro Arg Leu Gly Ala Phe Phe Leu
          35                  40                  45            
 Glu Arg Ser Ala Gly Ala Glu Thr Asp Asn Ala Val Pro Gln Thr Phe
      50                  55                  60                
 Ile Gly Arg Phe Arg Arg Ile Met Asp Ser Ser Gln Asn Ala Tyr Asn
  65                  70                  75                  80
 Glu Asp Thr Ser Ala Leu Val Ala Arg Leu Asp Glu Met Glu Arg Gly
                  85                  90                  95    
 Leu Phe Gln Thr Gly Gln Lys Gly Leu Asn Asp Phe Gln Cys Trp Glu
             100                 105                 110        
 Lys Gly Gln Ala Ser Gln Ile Thr Ala Ser Asn Leu Val Gln Asn Tyr
         115                 120                 125            
 Lys Lys Arg Lys Phe Thr Asp Met Glu Asp
     130                 135            



      <210> 635
      <211> 76
      <212> PRT
      <213> Homo sapiens


      <400> 635
 Met Asp Leu Arg Arg Val Lys Glu Tyr Phe Ser Trp Leu Tyr Tyr Gln
   1               5                  10                  15    
 Tyr Gln Ile Ile Ser Cys Cys Ala Val Leu Glu Pro Trp Glu Arg Ser
              20                  25                  30        
 Met Phe Asn Thr Ile Leu Leu Thr Ile Ile Ala Met Val Val Tyr Thr
          35                  40                  45            
 Ala Tyr Val Phe Ile Pro Ile His Ile Arg Leu Ala Trp Glu Phe Phe
      50                  55                  60                
 Ser Lys Ile Cys Gly Tyr His Ser Thr Ile Ser Asn
  65                  70                  75    



      <210> 636
      <211> 418
      <212> PRT
      <213> Homo sapiens


      <400> 636
 Met Phe Ser Pro Asp Gln Glu Asn His Pro Ser Lys Ala Pro Val Lys
   1               5                  10                  15    
 Tyr Gly Glu Leu Ile Val Leu Gly Tyr Asn Gly Ser Leu Pro Asn Gly
              20                  25                  30        
 Asp Arg Gly Arg Arg Lys Ser Arg Phe Ala Leu Phe Lys Arg Pro Lys
          35                  40                  45            
 Ala Asn Gly Val Lys Pro Ser Thr Val His Ile Ala Cys Thr Pro Gln
      50                  55                  60                
 Ala Ala Lys Ala Ile Ser Asn Lys Asp Gln His Ser Ile Ser Tyr Thr
  65                  70                  75                  80
 Leu Ser Arg Ala Gln Thr Val Val Val Glu Tyr Thr His Asp Ser Asn
                  85                  90                  95    
 Thr Asp Met Phe Gln Ile Gly Arg Ser Thr Glu Ser Pro Ile Asp Phe
             100                 105                 110        
 Val Val Thr Asp Thr Val Pro Gly Ser Gln Ser Asn Ser Asp Thr Gln
         115                 120                 125            
 Ser Val Gln Ser Thr Ile Ser Arg Phe Ala Cys Arg Ile Ile Cys Glu
     130                 135                 140                
 Arg Asn Pro Pro Phe Thr Ala Arg Ile Tyr Ala Ala Gly Phe Asp Ser
 145                 150                 155                 160
 Ser Lys Asn Ile Phe Leu Gly Glu Lys Ala Ala Lys Trp Lys Thr Ser
                 165                 170                 175    
 Asp Gly Gln Met Asp Gly Leu Thr Thr Asn Gly Val Leu Val Met His
             180                 185                 190        
 Pro Arg Asn Gly Phe Thr Glu Asp Ser Lys Pro Gly Ile Trp Arg Glu
         195                 200                 205            
 Ile Ser Val Cys Gly Asn Val Phe Ser Leu Arg Glu Thr Arg Ser Ala
     210                 215                 220                
 Gln Gln Arg Gly Lys Met Val Glu Ile Glu Thr Asn Gln Leu Gln Asp
 225                 230                 235                 240
 Gly Ser Leu Ile Asp Leu Cys Gly Ala Thr Leu Leu Trp Arg Thr Ala
                 245                 250                 255    
 Glu Gly Leu Ser His Thr Pro Thr Val Lys His Leu Glu Ala Leu Arg
             260                 265                 270        
 Gln Glu Ile Asn Ala Ala Arg Pro Gln Cys Pro Val Gly Phe Asn Thr
         275                 280                 285            
 Leu Ala Phe Pro Ser Met Lys Arg Lys Asp Val Val Asp Glu Lys Gln
     290                 295                 300                
 Pro Trp Val Tyr Leu Asn Cys Gly His Val His Gly Tyr His Asn Trp
 305                 310                 315                 320
 Gly Asn Lys Glu Glu Arg Asp Gly Lys Asp Arg Glu Cys Pro Met Cys
                 325                 330                 335    
 Arg Ser Val Gly Pro Tyr Val Pro Leu Trp Leu Gly Cys Glu Ala Gly
             340                 345                 350        
 Phe Tyr Val Asp Ala Gly Pro Pro Thr His Ala Phe Ser Pro Cys Gly
         355                 360                 365            
 His Val Cys Ser Glu Lys Thr Thr Ala Tyr Trp Ser Gln Ile Pro Leu
     370                 375                 380                
 Pro His Gly Thr His Thr Phe His Ala Ala Cys Pro Phe Cys Ala His
 385                 390                 395                 400
 Gln Leu Ala Gly Glu Gln Gly Tyr Ile Arg Leu Ile Phe Gln Gly Pro
                 405                 410                 415    
 Leu Asp
        



      <210> 637
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 637
 Met Thr Ser His Arg Ala Leu Ala Pro Thr Ser Pro His Leu Ser Leu
   1               5                  10                  15    
 Ser Pro Gln Glu His Thr Glu Val His Ile Thr Phe Pro Cys Pro His
              20                  25                  30        
 Cys Pro Pro Leu Pro His Ala Thr Pro Phe Pro Val Leu Pro Gln Leu
          35                  40                  45            
 Pro Ser Ser Lys Ser Gly Arg Asn Pro Gln Asp His Leu Gly Leu Pro
      50                  55                  60                
 Leu His Thr Gln Asn
  65                



      <210> 638
      <211> 206
      <212> PRT
      <213> Homo sapiens


      <400> 638
 Met Ser Ser Val Tyr Pro Arg Pro Leu Glu Gly Glu Ser Arg Ala Leu
   1               5                  10                  15    
 Arg Lys Gly Ser His Leu Leu Ser Leu Ala Glu Pro Leu Pro Pro Tyr
              20                  25                  30        
 Ser Ser Pro Glu Leu Ser Val Ala Phe His His Ser Gly Pro Ser Cys
          35                  40                  45            
 Leu Ser Pro Ala Leu Ser Gln Thr Thr Gln Lys Ser Gly His Leu Trp
      50                  55                  60                
 Ala Pro Gly Met Val Thr Glu Glu Lys His Ala Val Pro Val Ser Pro
  65                  70                  75                  80
 Gly Phe Cys Gln Lys Ile Glu Gln Val Gln Leu Thr His Cys Tyr Cys
                  85                  90                  95    
 Arg Ser Leu Lys Leu Pro Gly Leu Val Leu Asp Pro Ser Arg Asn His
             100                 105                 110        
 Gln Val Arg His Leu Glu Pro Pro Gly Glu Gly Pro Pro Ser Arg Ala
         115                 120                 125            
 Leu Lys Glu Leu His Glu Ile Arg Asn Cys Leu Met Lys Cys Ile Ser
     130                 135                 140                
 Leu Tyr Leu Glu Asp Glu Ala Gln Thr Pro Thr Pro Leu Ser Pro Pro
 145                 150                 155                 160
 Gly Leu Gly Met Ser Pro Ala Ala Arg Pro Arg Ser Phe Pro Gly Gly
                 165                 170                 175    
 Leu Gly Glu Val Gly Ala Gly Thr Ile Ser Val Pro Ser Thr Leu Thr
             180                 185                 190        
 Pro Ser Thr Ser Glu Thr Thr Leu Pro Gln Pro Asp Thr Glu
         195                 200                 205    



      <210> 639
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 639
 Met Leu Thr Arg Leu Val Leu Ser Ala His Leu Ser Ser Thr Thr Ser
   1               5                  10                  15    
 Pro Pro Trp Thr His Ala Ala Ile Ser Trp Glu Leu Asp Asn Val Leu
              20                  25                  30        
 Met Pro Ser Pro Arg Ile Trp Pro Gln Val Thr Pro Thr Ala Gly Gln
          35                  40                  45            
 Asp Val His Ala Ile Val Thr Arg Thr Cys Glu Ser Val Leu Ser Ser
      50                  55                  60                
 Ala Val Tyr Thr His Gly Cys Gly Cys Val Arg Ser Ala Thr Asn Ile
  65                  70                  75                  80
 Thr Cys Gln Ser Ser Gly Gln Gln Arg Gln Ala Ala Arg Gln Glu Glu
                  85                  90                  95    
 Glu Asn Ser Ile Cys Lys Ala His Asp Ser Arg Glu Gly Arg Leu Gly
             100                 105                 110        
 Tyr Pro Leu Ser Ala His Gln Pro Gly Ser Gly Gly Pro Asn
         115                 120                 125    



      <210> 640
      <211> 433
      <212> PRT
      <213> Homo sapiens


      <400> 640
 Met Phe Leu Leu Gly Leu Glu Asn Pro Ile Ser Ser Val Asp Thr Ala
   1               5                  10                  15    
 Ser Ala Met Ser Leu Glu Glu Trp Phe Ala Gly Ser Gly Cys Thr Phe
              20                  25                  30        
 Val Asp Thr Leu Gln Phe Ser Ala Leu Leu Arg Gly Ala Ser Arg Glu
          35                  40                  45            
 Met Leu Leu Ser Val Thr Ser Ser Tyr Ile Arg Leu Phe Ala Glu Gly
      50                  55                  60                
 Ile Tyr Gly Leu Ala Ala Arg Pro Leu Leu Ala Pro Pro Leu Pro Leu
  65                  70                  75                  80
 Pro Arg Thr Tyr Tyr Ala Leu Ser Arg Arg Arg Glu Tyr Gly His Arg
                  85                  90                  95    
 Glu Arg Leu Arg Glu Gly Leu Arg Met Arg Arg Gly Ala Ser Pro Leu
             100                 105                 110        
 Thr Asp Ser Arg Trp Arg Arg Gln Arg Arg Arg Pro Trp Thr Ala Gly
         115                 120                 125            
 Asn Gly Asn Pro Arg Ser Leu Thr Glu His Leu Pro Arg Leu Pro Ala
     130                 135                 140                
 Pro Asp Met Ala Gln Glu Lys Met Glu Leu Asp Leu Glu Leu Pro Pro
 145                 150                 155                 160
 Gly Thr Gly Gly Ser Pro Ala Glu Gly Gly Gly Ser Gly Gly Gly Gly
                 165                 170                 175    
 Gly Leu Arg Arg Ser Asn Ser Ala Pro Leu Ile His Gly Leu Ser Asp
             180                 185                 190        
 Thr Ser Pro Val Phe Gln Ala Glu Ala Pro Ser Ala Arg Arg Asn Ser
         195                 200                 205            
 Thr Thr Phe Pro Ser Arg His Gly Leu Leu Leu Pro Ala Ser Pro Val
     210                 215                 220                
 Arg Met His Ser Ser Arg Leu His Gln Ile Lys Gln Glu Glu Gly Met
 225                 230                 235                 240
 Asp Leu Ile Asn Arg Glu Thr Val His Glu Arg Glu Val Gln Thr Ala
                 245                 250                 255    
 Met Gln Ile Ser His Ser Trp Glu Glu Ser Phe Ser Leu Ser Asp Asn
             260                 265                 270        
 Asp Val Glu Lys Ser Ala Ser Pro Lys Arg Ile Asp Phe Ile Pro Val
         275                 280                 285            
 Ser Pro Ala Pro Ser Pro Thr Arg Gly Ile Gly Lys Gln Cys Phe Ser
     290                 295                 300                
 Pro Ser Leu Gln Ser Phe Val Ser Ser Asn Gly Leu Pro Pro Ser Pro
 305                 310                 315                 320
 Ile Pro Ser Pro Thr Thr Arg Phe Thr Thr Arg Arg Ser Gln Ser Pro
                 325                 330                 335    
 Ile Asn Cys Ile Arg Pro Ser Val Leu Gly Pro Leu Lys Arg Lys Cys
             340                 345                 350        
 Glu Met Glu Thr Glu Tyr Gln Pro Lys Arg Phe Phe Gln Gly Ile Thr
         355                 360                 365            
 Asn Met Leu Ser Ser Asp Val Ala Gln Leu Ser Asp Pro Gly Val Cys
     370                 375                 380                
 Val Ser Ser Asp Thr Leu Asp Gly Asn Ser Ser Ser Ala Gly Ser Ser
 385                 390                 395                 400
 Cys Asn Ser Pro Ala Lys Val Ser Thr Thr Thr Asp Ser Pro Val Ser
                 405                 410                 415    
 Pro Ala Gln Ala Ala Ser Pro Phe Ile Pro Leu Asp Glu Leu Ser Ser
             420                 425                 430        
 Lys
    



      <210> 641
      <211> 392
      <212> PRT
      <213> Homo sapiens


      <400> 641
 Met Glu Gln Lys Gln Gln Leu Phe Leu Gln His Gln Met Leu Ala Asp
   1               5                  10                  15    
 Ala Glu Lys Ile Ala Pro Gln Asp Gln Ile Asn Arg His Leu Ser Arg
              20                  25                  30        
 Pro Pro Pro Asp Tyr Lys Asp Gln Arg Arg Asn Val Gly Asn Met Gln
          35                  40                  45            
 Pro Thr Ala Gln Tyr Ser Gly Gly Ser Ser Thr Ile Ser Leu Asn Ser
      50                  55                  60                
 Asn Gln Ala Leu Ala Asn Pro Val Ser Thr His Thr Ile Leu Thr Pro
  65                  70                  75                  80
 Asn Ser Ser Leu Leu Ser Thr Ser His Gly Thr Arg Met Pro Ser Leu
                  85                  90                  95    
 Ser Thr Ala Val Gln Asn Met Gly Met Tyr Gly Asn Leu Pro Cys Asn
             100                 105                 110        
 Gln Pro Asn Thr Tyr Ser Val Thr Ser Gly Met Asn Gln Leu Thr Gln
         115                 120                 125            
 Gln Arg Asn Pro Lys Gln Leu Leu Ala Asn Gln Asn Asn Pro Met Met
     130                 135                 140                
 Pro Arg Pro Pro Thr Leu Gly Pro Ser Asn Asn Asn Asn Val Ala Thr
 145                 150                 155                 160
 Phe Gly Ala Gly Ser Val Gly Asn Ser Gln Gln Leu Arg Pro Asn Leu
                 165                 170                 175    
 Thr His Ser Met Ala Ser Met Pro Pro Gln Arg Thr Ser Asn Val Met
             180                 185                 190        
 Ile Thr Ser Asn Thr Thr Ala Pro Asn Trp Ala Ser Gln Glu Gly Thr
         195                 200                 205            
 Ser Lys Gln Gln Glu Ala Leu Thr Ser Ala Gly Val Arg Phe Pro Thr
     210                 215                 220                
 Gly Thr Pro Ala Ala Tyr Thr Pro Asn Gln Ser Leu Gln Gln Ala Val
 225                 230                 235                 240
 Gly Ser Gln Gln Phe Ser Gln Arg Ala Val Ala Pro Pro Asn Gln Leu
                 245                 250                 255    
 Thr Pro Ala Val Gln Met Arg Pro Met Asn Gln Met Ser Gln Thr Leu
             260                 265                 270        
 Asn Gly Gln Thr Met Gly Pro Leu Arg Gly Leu Asn Leu Arg Pro Asn
         275                 280                 285            
 Gln Leu Ser Thr Gln Ile Leu Pro Asn Leu Asn Gln Ser Gly Thr Gly
     290                 295                 300                
 Leu Asn Gln Ser Arg Thr Gly Ile Asn Gln Pro Pro Ser Leu Thr Pro
 305                 310                 315                 320
 Ser Asn Phe Pro Ser Pro Asn Gln Ser Ser Arg Ala Phe Gln Gly Thr
                 325                 330                 335    
 Asp His Ser Ser Asp Leu Ala Phe Asp Phe Leu Ser Gln Gln Asn Asp
             340                 345                 350        
 Asn Met Gly Pro Ala Leu Asn Ser Asp Ala Asp Phe Ile Asp Ser Leu
         355                 360                 365            
 Leu Lys Thr Glu Pro Gly Asn Asp Asp Trp Met Lys Asp Ile Asn Leu
     370                 375                 380                
 Asp Glu Ile Leu Gly Asn Asn Ser
 385                 390        



      <210> 642
      <211> 279
      <212> PRT
      <213> Homo sapiens


      <400> 642
 Met Asp Thr Gly Pro Leu Asn Ala Ala Ser Leu Arg Glu Glu Gln Leu
   1               5                  10                  15    
 His Leu Ser Leu Leu Val Ser Ser Gly Trp Arg Thr Ile Ser Phe His
              20                  25                  30        
 Val Val Pro Val Val Arg Arg Lys Leu Gly Ala Pro Ala Leu Glu Gly
          35                  40                  45            
 Val Gln Gln Met Pro Gly Phe Pro Glu Gly Ser Leu Arg Arg Ile Leu
      50                  55                  60                
 Ser Gln Gly Val Asp Leu Val Pro Ala Ser Ala Gln Leu Trp Arg Thr
  65                  70                  75                  80
 Ser Thr Asp Tyr Leu Leu Thr Arg Leu Leu Gly Glu Leu Gly Ser Leu
                  85                  90                  95    
 Gln Gly His Arg Leu Asp Ser Leu Ser Ile Leu Asp Arg Val Asn His
             100                 105                 110        
 Glu Ser Trp Arg Asp Ser Gly Gln Thr Asp Gly Leu Thr Phe Gly His
         115                 120                 125            
 Leu Lys Met Val Leu Leu Trp Ala Ser Val Leu Phe Pro Ala Pro Glu
     130                 135                 140                
 Asp Trp Ala Glu Pro Gln Gly Ala Val Tyr Arg Leu Leu Val Val Leu
 145                 150                 155                 160
 Leu Cys Cys Leu Ala Thr Arg Lys Leu Pro His Phe Leu His Pro Gln
                 165                 170                 175    
 Arg Asn Leu Leu Gln Gly Ser Gly Leu Asp Leu Gly Ala Ile Tyr Gln
             180                 185                 190        
 Arg Val Glu Gly Phe Ala Ser Gln Pro Glu Ala Ala Leu Arg Ile His
         195                 200                 205            
 Ala Thr His Leu Gly Arg Ser Pro Pro Pro Arg Ile Gly Ser Gly Leu
     210                 215                 220                
 Lys Ala Leu Leu Gln Leu Pro Ala Ser Asp Pro Thr Tyr Trp Ala Thr
 225                 230                 235                 240
 Ala Tyr Phe Asp Val Leu Leu Asp Lys Phe Gln Val Phe Asn Ile Gln
                 245                 250                 255    
 Asp Lys Asp Arg Ile Ser Ala Met Gln Ser Ile Phe Gln Lys Thr Arg
             260                 265                 270        
 Thr Leu Gly Gly Glu Glu Ser
         275                



      <210> 643
      <211> 191
      <212> PRT
      <213> Homo sapiens


      <400> 643
 Met Thr Ser Pro Glu Ile Glu Pro Phe Gly Ser Met Arg Asp Cys Val
   1               5                  10                  15    
 Ala Lys Ser Val Gly Gly Lys Ala Arg Leu Val Pro Trp Pro Arg Gly
              20                  25                  30        
 Phe Leu Gly Arg Gly His Gly Glu Glu Ala Pro Ala Gly Pro Ala His
          35                  40                  45            
 Gln Ser Trp Ala Arg Arg Gly Ser Lys Gln His Pro Ala Val Arg Gly
      50                  55                  60                
 Ser Leu Arg Pro Gly Met Arg Gly Trp Gln Thr Trp Glu Ser Gln Gly
  65                  70                  75                  80
 Arg Val Leu Arg Ser Glu Lys Asp Cys Pro Arg Asp Pro Trp Trp Thr
                  85                  90                  95    
 Ser Trp Val Leu Ser Gly Pro Cys Asp Ser Asp Asp Thr Lys Ala Ser
             100                 105                 110        
 Ala Phe Glu Trp Val Gln Val His Ala Arg Ala Trp Cys Phe Pro Ala
         115                 120                 125            
 Trp Pro Trp Arg Glu Leu Gly Gly Leu Ala Ser Gly Glu Asp Arg Ser
     130                 135                 140                
 Gln Asp Thr Arg Gln Pro Ser Arg Cys Gly Gly Cys Cys Ser Pro Arg
 145                 150                 155                 160
 Gln Trp Gly Gln Ala Leu Gly Asp Val Ser Asn Gly Gly Gln Pro Gly
                 165                 170                 175    
 Gln Ala Gly Glu Asp Met Phe Thr Gly Ile Tyr Gln Met Pro Pro
             180                 185                 190    



      <210> 644
      <211> 358
      <212> PRT
      <213> Homo sapiens


      <400> 644
 Met Ala Ala Val Leu Lys Pro Val Leu Leu Gly Leu Arg Asp Ala Pro
   1               5                  10                  15    
 Val His Gly Ser Pro Thr Gly Pro Gly Ala Trp Thr Ala Ser Lys Leu
              20                  25                  30        
 Gly Gly Ile Pro Asp Ala Leu Pro Thr Val Ala Ala Pro Arg Pro Val
          35                  40                  45            
 Cys Gln Arg Cys Gly Gln Pro Leu Ala Leu Val Val Gln Val Tyr Cys
      50                  55                  60                
 Pro Leu Glu Gly Ser Pro Phe His Arg Leu Leu His Val Phe Ala Cys
  65                  70                  75                  80
 Ala Cys Pro Gly Cys Ser Thr Gly Gly Ala Arg Ser Trp Lys Val Phe
                  85                  90                  95    
 Arg Ser Gln Cys Leu Gln Val Pro Glu Arg Glu Ala Gln Asp Ala Gln
             100                 105                 110        
 Lys Gln Gly Asn Ser Leu Ala Ala Glu Asp Trp Cys Glu Gly Ala Asp
         115                 120                 125            
 Asp Trp Gly Ser Asp Thr Glu Glu Gly Pro Ser Pro Gln Phe Thr Leu
     130                 135                 140                
 Asp Phe Gly Asn Asp Ala Ser Ser Ala Lys Asp Val Asp Trp Thr Ala
 145                 150                 155                 160
 Arg Leu Gln Asp Leu Arg Leu Gln Asp Ala Val Leu Gly Ala Ala His
                 165                 170                 175    
 Pro Val Pro Pro Gly Leu Pro Leu Phe Leu Pro Tyr Tyr Ile Cys Val
             180                 185                 190        
 Ala Asp Glu Asp Asp Tyr Arg Asp Phe Val Asn Leu Asp His Ala His
         195                 200                 205            
 Ser Leu Leu Arg Asp Tyr Gln Gln Arg Glu Gly Ile Ala Met Asp Gln
     210                 215                 220                
 Leu Leu Ser Gln Ser Leu Pro Asn Asp Gly Asp Glu Lys Tyr Glu Lys
 225                 230                 235                 240
 Thr Ile Ile Lys Ser Gly Asp Gln Thr Phe Tyr Lys Phe Met Lys Arg
                 245                 250                 255    
 Ile Ala Ala Cys Gln Glu Gln Ile Leu Arg Tyr Ser Trp Ser Gly Glu
             260                 265                 270        
 Pro Leu Phe Leu Thr Cys Pro Thr Ser Glu Val Thr Glu Leu Pro Ala
         275                 280                 285            
 Cys Ser Gln Cys Gly Gly Gln Arg Ile Phe Glu Phe Gln Leu Met Pro
     290                 295                 300                
 Ala Leu Val Ser Met Leu Lys Ser Ala Asn Leu Gly Leu Ser Val Glu
 305                 310                 315                 320
 Phe Gly Thr Ile Leu Val Tyr Thr Cys Glu Lys Ser Cys Trp Pro Pro
                 325                 330                 335    
 Asn His Gln Thr Pro Met Glu Glu Phe Cys Ile Ile Gln Glu Asp Pro
             340                 345                 350        
 Asp Glu Leu Leu Phe Lys
         355            



      <210> 645
      <211> 295
      <212> PRT
      <213> Homo sapiens


      <400> 645
 Met Pro Tyr Gly Ser Val Leu Ala Phe Leu Pro Ala Asp Glu Met Leu
   1               5                  10                  15    
 Gly Ala Phe Asn Glu Leu Lys Leu His Leu His Glu Glu Ala Arg Glu
              20                  25                  30        
 Ile Thr Asp Trp Phe Glu Asp Asn Asp Val His Gly Arg Ile Arg Arg
          35                  40                  45            
 His Ala Leu Glu Leu Leu Phe Asp His Gln Tyr Cys Phe His Gln Ile
      50                  55                  60                
 Cys Asp Leu His Ile Ser Thr Ala His Met Ile Glu Ala Asp Val Leu
  65                  70                  75                  80
 Leu Pro Ser Asp Gly Ser Glu His Ser Gln Pro Ile Met Ala His Pro
                  85                  90                  95    
 Pro Glu Thr Asn Ser Asp Asn Thr Leu Gln Glu Trp Leu Thr Glu Val
             100                 105                 110        
 Met Lys Ser Asn Lys Gly Ile Lys Leu Asp Phe Lys Ser Leu Ala Val
         115                 120                 125            
 Val Glu Pro Ser Met Met Leu Leu Glu Asn Val Lys Arg His Leu Lys
     130                 135                 140                
 Arg Pro Val Trp Ile Asn Ala Asp Ile Leu Pro Gly Pro Asn Gly Asn
 145                 150                 155                 160
 Ser Lys Val Ile Asp Ala Lys Pro Phe Leu Asp Thr Val Ile Ser Phe
                 165                 170                 175    
 Phe Pro Asp Val Thr Phe Ser Leu Gly Trp Thr Thr Gly Trp His Pro
             180                 185                 190        
 Glu Lys Val Asn Glu Gly Tyr Ser Trp Thr Met Val Lys Glu Met Glu
         195                 200                 205            
 Tyr Ile Cys Asn Glu Leu Ser Gln Pro Val Thr Phe Pro Val Arg Ala
     210                 215                 220                
 Ala Leu Val Arg Gln Ser Cys Ser Gln Leu Leu Trp Leu Leu Lys Lys
 225                 230                 235                 240
 Ser Asn Arg Tyr Ser Leu Thr Ile Trp Thr Gly Lys Asn Asp Asn Tyr
                 245                 250                 255    
 Ser Val Glu Asp Leu Leu Tyr Ile Arg Asp His Phe Asp Lys Lys Gln
             260                 265                 270        
 Val Phe Tyr Asp Ile Leu Glu Pro Gln Asn His Glu Phe Lys Gln Ala
         275                 280                 285            
 Ile Gly Ile Lys Val Asn Leu
     290                 295



      <210> 646
      <211> 256
      <212> PRT
      <213> Homo sapiens


      <400> 646
 Met Arg Glu Val Arg Ala Arg Leu Ala Ala Thr Gln Val Glu Tyr Ile
   1               5                  10                  15    
 Ser Gly Lys Val Phe Phe Thr Thr Cys Ser Asp Leu Asn Met Leu Lys
              20                  25                  30        
 Lys Leu Lys Ser Ala Glu Arg Leu Phe Leu Leu Ile Lys Lys Gln Phe
          35                  40                  45            
 Pro Leu Ile Ile Ser Ser Val Ser Lys Gly Lys Ile Phe Asn Glu Met
      50                  55                  60                
 Gln Arg Leu Ile Asn Glu Asp Pro Gly Ser Trp Leu Asn Ala Ile Ser
  65                  70                  75                  80
 Ile Trp Lys Asn Leu Leu Glu Leu Asp Ala Lys Lys Glu Lys Leu Ser
                  85                  90                  95    
 Gln Arg Asp Asp Asn Gln Leu Lys Arg Lys Val Gly Glu Asn Glu Ile
             100                 105                 110        
 Ile Ala Lys Lys Leu Lys Ile Glu Gln Met Gln Lys Ile Glu Glu Asn
         115                 120                 125            
 Arg Asp Cys Gln Leu Glu Lys Gln Ile Lys Glu Glu Thr Leu Glu Gln
     130                 135                 140                
 Arg Asp Phe Thr Thr Lys Ser Glu Lys Phe Gln Glu Glu Glu Phe Gln
 145                 150                 155                 160
 Asn Asp Ile Glu Lys Ala Ile Asp Thr His Asn Gln Asn Asp Leu Thr
                 165                 170                 175    
 Phe Arg Val Ser Cys Arg Cys Ser Gly Thr Ile Gly Lys Ala Phe Thr
             180                 185                 190        
 Ala Gln Glu Val Gly Gln Arg Asn Trp Asn Ala Tyr Tyr Glu Thr Leu
         195                 200                 205            
 Trp Met Glu Arg Arg Leu Glu Glu Phe His Gln Leu Arg Asp Leu Ile
     210                 215                 220                
 Thr Leu Asn Asp Ile Tyr Ser Val Val Gly Ile Pro Val Phe Arg Val
 225                 230                 235                 240
 Ser Leu Ala Ser Arg Val Thr Ser Arg Gln Leu Asp Cys Asp Leu Gln
                 245                 250                 255    





      <210> 647
      <211> 82
      <212> PRT
      <213> Homo sapiens


      <400> 647
 Met Lys Val Lys Glu Lys Lys Lys Thr Ala Asn Leu Glu Asn Phe Leu
   1               5                  10                  15    
 Glu Lys Asn Tyr Leu Lys Leu Ser Asp Pro Asp Gln Gln Ala Pro Pro
              20                  25                  30        
 Gln Pro Pro Phe Gln Val Thr Pro Cys Leu Glu Cys Val Cys Val Phe
          35                  40                  45            
 Thr Pro Val Pro Leu Leu Ala Ala Pro Val Arg Ala Ala Pro Leu Pro
      50                  55                  60                
 Cys Pro Pro Gln Asn Trp Val Pro Arg Ala Val Pro Asp Asn Cys Gln
  65                  70                  75                  80
 Arg His
        



      <210> 648
      <211> 41
      <212> PRT
      <213> Homo sapiens


      <400> 648
 Met Leu Val Val Lys Gln Cys Phe Ser Asp Ser Ser Ile Leu Ser Thr
   1               5                  10                  15    
 Phe Val Ser Trp Leu Ser Ala Phe Tyr Cys Lys Glu Gly Pro Ser Phe
              20                  25                  30        
 Leu Pro Arg Lys Val Phe Leu Phe Phe
          35                  40    



      <210> 649
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 649
 Met Pro Trp Asn Val Arg Met Gln Ser Pro Lys Gln Arg Thr Ser Arg
   1               5                  10                  15    
 Cys Trp Asp His His Ile Ala Glu Gly Cys Phe Cys Leu Pro Trp Lys
              20                  25                  30        
 Lys Ile Leu Ile Phe Glu Lys Arg Gln Asp Ser Gln Asn Glu Asn Glu
          35                  40                  45            
 Arg Met Ser Ser Thr Pro Ile Gln Gln Asp Asn Val Asp Gln Thr Tyr
      50                  55                  60                
 Ser Glu Glu Leu Cys Tyr Thr Leu Ile Asn His Arg Val Leu Cys Thr
  65                  70                  75                  80
 Arg Pro Ser Gly Asn Ser Ala Glu Glu Tyr Tyr Glu Asn Val Pro Cys
                  85                  90                  95    
 Lys Ala Glu Arg Pro Arg Glu Ser Leu Gly Gly Thr Glu Thr Glu Tyr
             100                 105                 110        
 Ser Leu Leu His Met Pro Ser Thr Asp Pro Arg His Ala Arg Ser Pro
         115                 120                 125            
 Glu Asp Glu Tyr Glu Leu Leu Met Pro His Arg Ile Ser Ser His Phe
     130                 135                 140                
 Leu Gln Gln Pro Arg Pro Leu Met Ala Pro Ser Glu Thr Gln Phe Ser
 145                 150                 155                 160
 His Leu
        



      <210> 650
      <211> 581
      <212> PRT
      <213> Homo sapiens


      <400> 650
 Met Glu Cys Leu Gly Met Leu His Glu Ser Gln Glu Glu Ile Lys Glu
   1               5                  10                  15    
 Leu Arg Ser Arg Ser Gly Pro Thr Ala His Leu Tyr Phe Ser Gln Ser
              20                  25                  30        
 Tyr Gly Ala Phe Thr Gly Glu Ser Leu Ala Ala Glu Ile Glu Gly Thr
          35                  40                  45            
 Met Arg Lys Lys Leu Ser Leu Asp Glu Glu Ser Ser Leu Phe Lys Gln
      50                  55                  60                
 Lys Ala Gln Gln Lys Arg Val Phe Asp Thr Val Arg Ile Ala Asn Asp
  65                  70                  75                  80
 Thr Arg Gly Arg Ser Ile Ser Phe Pro Ala Leu Leu Pro Ile Pro Gly
                  85                  90                  95    
 Ser Asn Arg Ser Ser Val Ile Met Thr Ala Lys Pro Phe Glu Ser Gly
             100                 105                 110        
 Leu Gln Gln Thr Glu Asp Lys Ser Leu Leu Asn Gln Gly Ser Ser Ser
         115                 120                 125            
 Glu Glu Val Ala Gly Ser Ser Gln Lys Met Gly Gln Pro Gly Pro Ser
     130                 135                 140                
 Gly Asp Ser Asp Leu Ala Thr Ala Leu His Arg Leu Ser Leu Arg Arg
 145                 150                 155                 160
 Gln Asn Tyr Leu Ser Glu Lys Gln Phe Phe Ala Glu Glu Trp Gln Arg
                 165                 170                 175    
 Lys Ile Gln Val Leu Ala Asp Gln Lys Glu Gly Val Ser Gly Cys Val
             180                 185                 190        
 Thr Pro Thr Glu Ser Leu Ala Ser Leu Cys Thr Thr Gln Ser Glu Ile
         195                 200                 205            
 Thr Asp Leu Ser Ser Ala Ser Cys Leu Arg Gly Phe Met Pro Glu Lys
     210                 215                 220                
 Leu Gln Ile Val Lys Pro Leu Glu Gly Ser Gln Thr Leu Tyr His Trp
 225                 230                 235                 240
 Gln Gln Leu Ala Gln Pro Asn Leu Gly Thr Ile Leu Asp Pro Arg Pro
                 245                 250                 255    
 Gly Val Ile Thr Lys Gly Phe Thr Gln Leu Pro Gly Asp Ala Ile Tyr
             260                 265                 270        
 His Ile Ser Asp Leu Glu Glu Asp Glu Glu Glu Gly Ile Thr Phe Gln
         275                 280                 285            
 Val Gln Gln Pro Leu Glu Val Glu Glu Lys Leu Ser Thr Ser Lys Pro
     290                 295                 300                
 Val Thr Gly Ile Phe Leu Pro Pro Ile Thr Ser Ala Gly Gly Pro Val
 305                 310                 315                 320
 Thr Val Ala Thr Ala Asn Pro Gly Lys Cys Leu Ser Cys Thr Asn Ser
                 325                 330                 335    
 Thr Phe Thr Phe Thr Thr Cys Arg Ile Leu His Pro Ser Asp Ile Thr
             340                 345                 350        
 Gln Val Thr Pro Ser Ser Gly Phe Pro Ser Leu Ser Cys Gly Ser Ser
         355                 360                 365            
 Gly Ser Ser Ser Ser Asn Thr Ala Val Asn Ser Pro Ala Leu Ser Tyr
     370                 375                 380                
 Arg Leu Ser Ile Gly Glu Ser Ile Thr Asn Arg Arg Asp Ser Thr Thr
 385                 390                 395                 400
 Thr Phe Ser Ser Thr Met Ser Leu Ala Lys Leu Leu Gln Glu Arg Gly
                 405                 410                 415    
 Ile Ser Ala Lys Val Tyr His Ser Pro Ile Ser Glu Asn Pro Leu Gln
             420                 425                 430        
 Pro Leu Pro Lys Ser Leu Ala Ile Pro Ser Thr Pro Pro Asn Ser Pro
         435                 440                 445            
 Ser His Ser Pro Cys Pro Ser Pro Leu Pro Phe Glu Pro Arg Val His
     450                 455                 460                
 Leu Ser Glu Asn Phe Leu Ala Ser Arg Pro Ala Glu Thr Phe Leu Gln
 465                 470                 475                 480
 Glu Met Tyr Gly Leu Arg Pro Ser Arg Asn Pro Pro Asp Val Gly Gln
                 485                 490                 495    
 Leu Lys Met Asn Leu Val Asp Arg Leu Lys Arg Leu Gly Ile Ala Arg
             500                 505                 510        
 Val Val Lys Asn Pro Gly Ala Gln Glu Asn Gly Arg Cys Gln Glu Ala
         515                 520                 525            
 Glu Asn Gly Pro Gln Lys Pro Asp Ser Ala Val Tyr Leu Asn Ser Gly
     530                 535                 540                
 Ser Ser Leu Leu Gly Gly Leu Arg Arg Asn Gln Ser Leu Pro Val Ile
 545                 550                 555                 560
 Met Gly Ser Phe Ala Ala Pro Val Cys Thr Ser Ser Pro Lys Met Gly
                 565                 570                 575    
 Val Leu Lys Glu Asp
             580    



      <210> 651
      <211> 265
      <212> PRT
      <213> Homo sapiens


      <400> 651
 Met Ser Ala Ala Pro Leu Val Gly Tyr Ser Ser Ser Gly Ser Glu Asp
   1               5                  10                  15    
 Glu Ser Glu Asp Gly Met Arg Thr Arg Pro Gly Asp Gly Ser His Arg
              20                  25                  30        
 Arg Gly Gln Ser Pro Leu Pro Arg Gln Arg Phe Pro Val Pro Asp Ser
          35                  40                  45            
 Val Leu Asn Met Phe Pro Gly Thr Glu Glu Gly Pro Glu Asp Asp Ser
      50                  55                  60                
 Thr Lys His Gly Gly Arg Val Arg Thr Phe Pro His Glu Arg Gly Asn
  65                  70                  75                  80
 Trp Ala Thr His Val Tyr Val Pro Tyr Glu Ala Lys Glu Glu Phe Leu
                  85                  90                  95    
 Asp Leu Leu Asp Val Leu Leu Pro His Ala Gln Thr Tyr Val Pro Arg
             100                 105                 110        
 Leu Val Arg Met Lys Val Phe His Leu Ser Leu Ser Gln Ser Val Val
         115                 120                 125            
 Leu Arg His His Trp Ile Leu Pro Phe Val Gln Ala Leu Lys Ala Arg
     130                 135                 140                
 Met Thr Ser Phe His Arg Phe Phe Phe Thr Ala Asn Gln Val Lys Ile
 145                 150                 155                 160
 Tyr Thr Asn Gln Glu Lys Thr Arg Thr Phe Ile Gly Leu Glu Val Thr
                 165                 170                 175    
 Ser Gly His Ala Gln Phe Leu Asp Leu Val Ser Glu Val Asp Arg Val
             180                 185                 190        
 Met Glu Glu Phe Asn Leu Thr Thr Phe Tyr Gln Asp Pro Ser Phe His
         195                 200                 205            
 Leu Ser Leu Ala Trp Cys Val Gly Asp Ala Arg Leu Gln Leu Glu Gly
     210                 215                 220                
 Gln Cys Leu Gln Glu Leu Gln Ala Ile Val Asp Gly Phe Glu Asp Ala
 225                 230                 235                 240
 Glu Val Leu Leu Arg Val His Thr Glu Gln Val Arg Cys Lys Ser Gly
                 245                 250                 255    
 Asn Lys Phe Phe Ser Met Pro Leu Lys
             260                 265



      <210> 652
      <211> 318
      <212> PRT
      <213> Homo sapiens


      <400> 652
 Met Arg Leu Val Val Thr Ala Asp Asp Phe Gly Tyr Cys Pro Arg Arg
   1               5                  10                  15    
 Asp Glu Gly Ile Val Glu Ala Phe Leu Ala Gly Ala Val Thr Ser Val
              20                  25                  30        
 Ser Leu Leu Val Asn Gly Ala Ala Thr Glu Ser Ala Ala Glu Leu Ala
          35                  40                  45            
 Arg Arg His Ser Ile Pro Thr Gly Leu His Ala Asn Leu Ser Glu Gly
      50                  55                  60                
 Arg Pro Val Gly Pro Ala Arg Arg Gly Ala Ser Ser Leu Leu Gly Pro
  65                  70                  75                  80
 Glu Gly Phe Phe Leu Gly Lys Met Gly Phe Arg Glu Ala Val Ala Ala
                  85                  90                  95    
 Gly Asp Val Asp Leu Pro Gln Val Arg Glu Glu Leu Glu Ala Gln Leu
             100                 105                 110        
 Ser Cys Phe Arg Glu Leu Leu Gly Arg Ala Pro Thr His Ala Asp Gly
         115                 120                 125            
 His Gln His Val His Val Leu Pro Gly Val Cys Gln Val Phe Ala Glu
     130                 135                 140                
 Ala Leu Gln Ala Tyr Gly Val Arg Phe Thr Arg Leu Pro Leu Glu Arg
 145                 150                 155                 160
 Gly Val Gly Gly Cys Thr Trp Leu Glu Ala Pro Ala Arg Ala Phe Ala
                 165                 170                 175    
 Cys Ala Val Glu Arg Asp Ala Arg Ala Ala Val Gly Pro Phe Ser Arg
             180                 185                 190        
 His Gly Leu Arg Trp Thr Asp Ala Phe Val Gly Leu Ser Thr Cys Gly
         195                 200                 205            
 Arg His Met Ser Ala His Arg Val Ser Gly Ala Leu Ala Arg Val Leu
     210                 215                 220                
 Glu Gly Thr Leu Ala Gly His Thr Leu Thr Ala Glu Leu Met Ala His
 225                 230                 235                 240
 Pro Gly Tyr Pro Ser Val Pro Pro Thr Gly Gly Cys Gly Glu Gly Pro
                 245                 250                 255    
 Asp Ala Phe Ser Cys Ser Trp Glu Arg Leu His Glu Leu Arg Val Leu
             260                 265                 270        
 Thr Ala Pro Thr Leu Arg Ala Gln Leu Ala Gln Asp Gly Val Gln Leu
         275                 280                 285            
 Cys Ala Leu Asp Asp Leu Asp Ser Lys Arg Pro Gly Glu Glu Val Pro
     290                 295                 300                
 Cys Glu Pro Thr Leu Glu Pro Phe Leu Glu Pro Ser Leu Leu
 305                 310                 315            



      <210> 653
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 653
 Met Gln Trp Asn Val Pro Arg Thr Val Ser Arg Leu Ala Arg Arg Thr
   1               5                  10                  15    
 Cys Leu Glu Pro His Asn Ala Gly Leu Phe Gly His Cys Gln Asn Val
              20                  25                  30        
 Lys Gly Pro Leu Leu Leu Tyr Asn Ala Glu Ser Lys Val Val Leu Val
          35                  40                  45            
 Gln Gly Pro Gln Lys Gln Trp Leu His Leu Ser Ala Ala Gln Cys Val
      50                  55                  60                
 Ala Lys Glu Arg Arg Pro Leu Asp Ala His Pro Pro Gln Pro Gly Val
  65                  70                  75                  80
 Leu Arg His Lys Gln Gly Lys Gln His Val Ser Phe Arg Arg Val Phe
                  85                  90                  95    
 Ser Ser Ser Ala Thr Ala Gln Gly Thr Pro Glu Lys Lys Glu Glu Pro
             100                 105                 110        
 Asp Pro Leu Gln Asp Lys Ser Ile Ser Leu Tyr Gln Arg Phe Lys Lys
         115                 120                 125            
 Thr Phe Arg Gln Tyr Gly Lys Val Leu Ile Pro Val His Leu Ile Thr
     130                 135                 140                
 Ser Gly Val Trp Phe Gly Thr Phe Tyr Tyr Ala Ala Leu Lys Gly Val
 145                 150                 155                 160
 Asn Val Val Pro Phe Leu Glu Leu Ile Gly Leu Pro Asp Ser Val Val
                 165                 170                 175    
 Ser Ile Leu Lys Asn Ser Gln Ser Gly Asn Ala Leu Thr Ala Tyr Ala
             180                 185                 190        
 Leu Phe Lys Ile Ala Thr Pro Ala Arg Tyr Thr Val Thr Leu Gly Gly
         195                 200                 205            
 Thr Ser Val Thr Val Lys Tyr Leu Arg Ser His Gly Tyr Met Ser Thr
     210                 215                 220                
 Pro Pro Pro Val Lys Glu Tyr Leu Gln Asp Arg Met Glu Glu Thr Lys
 225                 230                 235                 240
 Glu Leu Ile Thr Glu Lys Met Glu Glu Thr Lys Asp Arg Leu Thr Glu
                 245                 250                 255    
 Lys Leu Gln Glu Thr Lys Glu Lys Val Ser Phe Lys Lys Lys Val Glu
             260                 265                 270        





      <210> 654
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 654
 Met Val Arg Lys Val Asn Ala His Leu Pro Leu Ser Phe Pro Thr Val
   1               5                  10                  15    
 Glu Thr Asp Ser Arg Glu Ile Leu Gln Val Arg Cys Tyr Val Gly Leu
              20                  25                  30        
 Arg Glu Arg Cys Tyr Asp Gln Thr Glu Pro Phe Ser Leu Pro Ser Val
          35                  40                  45            
 His Gly Phe Ser Trp Leu Cys Gly Pro Val Ser Cys His Ser Phe Thr
      50                  55                  60                
 Pro Asn Phe Trp Asp Ile Gln Gly Asn Asn Leu Ala Thr Gly Tyr Leu
  65                  70                  75                  80
 Leu Val Glu Ile Met Trp
                  85    



      <210> 655
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 655
 Met Asp Lys Leu Thr Ile Ile Ser Gly Cys Leu Phe Leu Ala Ala Asp
   1               5                  10                  15    
 Ile Phe Ala Ile Ala Ser Ile Ala Asn Pro Asp Trp Ile Asn Thr Gly
              20                  25                  30        
 Glu Ser Ala Gly Ala Leu Thr Val Gly Leu Val Arg Gln Cys Gln Thr
          35                  40                  45            
 Ile His Gly Arg Asp Arg Thr Cys Ile Pro Pro Arg Leu Pro Pro Glu
      50                  55                  60                
 Trp Val Thr Thr Leu Phe Phe Ile Ile Met Gly Ile Ile Ser Leu Thr
  65                  70                  75                  80
 Val Thr Cys Gly Leu Leu Val Ala Ser His Trp Arg Arg Glu Ala Thr
                  85                  90                  95    
 Lys Tyr Ala Arg Trp Ile Ala Phe Thr Gly Met Ile Leu Phe Cys Met
             100                 105                 110        
 Ala Ala Leu Ile Phe Pro Ile Gly Phe Tyr Ile Asn Glu Val Gly Gly
         115                 120                 125            
 Gln Pro Tyr Lys Leu Pro Asn Asn Thr Val Val Gly Ser Ser Tyr Val
     130                 135                 140                
 Leu Phe Val Leu Ser Ile Phe Phe Thr Ile Val Gly Leu Leu Phe Ala
 145                 150                 155                 160
 Gly Lys Val Cys Leu Pro Gly
                 165        



      <210> 656
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 656
 Met Ser Glu Val Ala Ser Ala Ala Ser Arg Gln Ile Pro Gly Asn Pro
   1               5                  10                  15    
 Glu Pro Gln Asn Val Ile Pro Pro Gly Ser Ala Trp Pro Asp Pro Val
              20                  25                  30        
 Leu Ser Ala Gly Phe Thr Tyr Gln Ser His Ser Ser Phe Ser Ile Pro
          35                  40                  45            
 Thr Pro Lys Ser Ser Pro Asn His His Leu Val Phe Phe Phe
      50                  55                  60        



      <210> 657
      <211> 373
      <212> PRT
      <213> Homo sapiens


      <400> 657
 Met Asn Ser Ser Asp Glu Leu Cys Glu Ser Val Ser Val His Pro Leu
   1               5                  10                  15    
 Gln Met Thr Gly Leu Thr Asp Ile Ala Asp Ile Ile Asp Asp Leu Ile
              20                  25                  30        
 Ile Lys Asp Gly Val Ser Ser Glu Glu Leu Gly Leu Thr Glu Gln Ala
          35                  40                  45            
 Met Gly Thr Ser Arg Ile Gln His Tyr Ser Gly Arg His Ser Gln Arg
      50                  55                  60                
 Thr Asp Lys Glu Arg Arg Glu Ile Gln Ala Trp Met Lys Arg Lys Arg
  65                  70                  75                  80
 Lys Glu Arg Met Ala Lys Tyr Leu Asn Glu Leu Ala Glu Lys Arg Gly
                  85                  90                  95    
 Gln Glu His Asp Pro Phe Cys Pro Arg Ser Asn Pro Leu Tyr Met Thr
             100                 105                 110        
 Ser Arg Glu Ile Arg Leu Arg Gln Lys Met Lys His Glu Lys Asp Arg
         115                 120                 125            
 Leu Leu Leu Ser Glu His Tyr Ser Arg Arg Ile Ser Gln Ala Tyr Gly
     130                 135                 140                
 Leu Met Asn Glu Leu Leu Ser Glu Ser Val Gln Leu Pro Thr Leu Pro
 145                 150                 155                 160
 Gln Lys Pro Leu Pro Asn Lys Pro Ser Pro Thr Gln Ser Ser Ser Cys
                 165                 170                 175    
 Gln His Cys Pro Ser Pro Arg Gly Glu Asn Gln His Gly His Ser Phe
             180                 185                 190        
 Leu Ile Asn Arg Pro Gly Lys Val Lys Tyr Met Ser Lys Pro Ser Tyr
         195                 200                 205            
 Ile His Lys Arg Lys Ser Phe Gly Gln Pro Gln Gly Ser Pro Trp Pro
     210                 215                 220                
 His Gly Thr Ala Thr Phe Thr Ile Gln Lys Lys Ala Gly Gly Ala Lys
 225                 230                 235                 240
 Ala Ala Val Arg Lys Ala Thr Gln Ser Pro Val Thr Phe Gln Lys Gly
                 245                 250                 255    
 Ser Asn Ala Pro Cys His Ser Leu Gln His Thr Lys Lys His Gly Ser
             260                 265                 270        
 Ala Gly Leu Ala Pro Gln Thr Lys Gln Val Cys Val Glu Tyr Glu Arg
         275                 280                 285            
 Glu Glu Thr Val Val Ser Pro Trp Thr Ile Pro Ser Glu Ile His Lys
     290                 295                 300                
 Ile Leu His Glu Ser His Asn Ser Leu Leu Gln Asp Leu Ser Pro Thr
 305                 310                 315                 320
 Glu Glu Glu Glu Pro Glu His Pro Phe Gly Val Gly Gly Val Asp Ser
                 325                 330                 335    
 Val Ser Glu Ser Thr Gly Ser Ile Leu Ser Lys Leu Asp Trp Asn Ala
             340                 345                 350        
 Ile Glu Asp Met Val Ala Ser Val Glu Asp Gln Gly Leu Ser Val His
         355                 360                 365            
 Trp Ala Leu Asp Leu
     370            



      <210> 658
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 658
 Met Lys Leu Arg Arg Glu Gln Trp Leu Gln Lys Ile Glu Ala Ile Lys
   1               5                  10                  15    
 Leu Ala Glu Gln Lys His Arg Glu Glu Arg Arg Arg Arg Ala Thr Val
              20                  25                  30        
 Val Val Gly Asp Leu His Pro Leu Arg Asp Ala Leu Pro Glu Leu Leu
          35                  40                  45            
 Gly Leu Glu Ala Gly Ser Arg Arg Gln Ala Arg Ser Arg Glu Ser Asn
      50                  55                  60                
 Lys Pro Arg Pro Ser Glu Leu Ser Arg Met Ser Ala Ala Gln Arg Gln
  65                  70                  75                  80
 Gln Leu Leu Glu Glu Glu Arg Thr Arg Phe Gln Glu Leu Leu Ala Ser
                  85                  90                  95    
 Pro Ala Tyr Arg Ala Ser Pro Leu Val Ala Ile Gly Gln Thr Leu Ala
             100                 105                 110        
 Arg Gln Met Gln Leu Glu Asp Gly Gly Gln Leu
         115                 120            



      <210> 659
      <211> 166
      <212> PRT
      <213> Homo sapiens


      <400> 659
 Met Arg Gln Ala Leu Gly Leu Phe Leu Asn Val Val Lys Ser Arg Thr
   1               5                  10                  15    
 Val Ser Ser His Gly Val Asp Tyr Ser Val Leu Asp Lys Asp Ile Pro
              20                  25                  30        
 Pro Arg Glu Gly Thr Leu His Gly Ala Ser Gly Ala Thr Ile His Gly
          35                  40                  45            
 Val Gln Ala Val Ala Leu Glu Arg Thr Trp Ala Gly Leu Pro Gln Pro
      50                  55                  60                
 Leu Leu Tyr Pro Ser Phe Thr Pro Leu Ile Thr Thr Met Ala Leu Phe
  65                  70                  75                  80
 Ser Phe Gly Ala Asn Ile Ser Ile Phe Gln Leu Ser Leu Asp Phe Asp
                  85                  90                  95    
 Phe Ile Lys Gly Lys Glu Asn Ile Tyr Ile Cys Lys Tyr Leu His Val
             100                 105                 110        
 Ser Val Cys Val Tyr Ile Cys Ile Tyr Ile Cys Ile Tyr Ala Phe Ile
         115                 120                 125            
 Asp Lys Ile Ile Met Val Ala Glu Ala Ser Asn Phe Val Lys Ile Ser
     130                 135                 140                
 Val Tyr Tyr Lys Pro Leu Phe Lys His Thr Tyr Asp Thr Glu Asn Ile
 145                 150                 155                 160
 Gln Arg Leu Asn Cys Pro
                 165    



      <210> 660
      <211> 508
      <212> PRT
      <213> Homo sapiens


      <400> 660
 Met Val His Pro Ser Phe Lys Glu Leu Phe Gln Asp Ser Trp Thr Pro
   1               5                  10                  15    
 Glu Leu Lys Leu Lys Leu Glu Lys Phe Leu Ala Leu Ile Ser Lys Ala
              20                  25                  30        
 Ser Asn Thr Pro Lys Leu Leu Thr Ile Tyr Lys Glu Asn Gly Gln Ser
          35                  40                  45            
 Asn Lys Glu Ile Leu Gln Gln Leu His Gln Gln Leu Val Glu Ala Glu
      50                  55                  60                
 Arg Arg Ser Val Thr Tyr Leu Lys Arg Tyr Asn Lys Ile Gln Ala Asp
  65                  70                  75                  80
 Tyr His Asn Leu Ile Gly Val Thr Ala Glu Leu Val Asp Ser Leu Glu
                  85                  90                  95    
 Ala Thr Val Ser Gly Lys Met Ile Thr Pro Glu Tyr Leu Gln Ser Val
             100                 105                 110        
 Cys Val Arg Leu Phe Ser Asn Gln Met Arg Gln Ser Leu Ala His Ser
         115                 120                 125            
 Val Asp Phe Thr Arg Pro Gly Thr Ala Ser Thr Met Leu Arg Ala Ser
     130                 135                 140                
 Leu Ala Pro Val Lys Leu Lys Asp Val Pro Leu Leu Pro Ser Leu Asp
 145                 150                 155                 160
 Tyr Glu Lys Leu Lys Lys Asp Leu Ile Leu Gly Ser Asp Arg Leu Lys
                 165                 170                 175    
 Ala Phe Leu Leu Gln Ala Leu Arg Trp Arg Leu Thr Thr Ser His Pro
             180                 185                 190        
 Gly Glu Gln Arg Glu Thr Val Leu Gln Ala Tyr Ile Ser Asn Asp Leu
         195                 200                 205            
 Leu Asp Cys Tyr Ser His Asn Gln Arg Ser Val Leu Gln Leu Leu His
     210                 215                 220                
 Ser Thr Ser Asp Val Val Arg Gln Tyr Met Ala Arg Leu Ile Asn Ala
 225                 230                 235                 240
 Phe Ala Ser Leu Ala Glu Gly Arg Leu Tyr Leu Ala Gln Asn Thr Lys
                 245                 250                 255    
 Val Leu Gln Met Leu Glu Gly Arg Leu Lys Glu Glu Asp Lys Asp Ile
             260                 265                 270        
 Ile Thr Arg Glu Asn Val Leu Gly Ala Leu Gln Lys Phe Ser Leu Arg
         275                 280                 285            
 Arg Pro Leu Gln Thr Ala Met Ile Gln Asp Gly Leu Ile Phe Trp Leu
     290                 295                 300                
 Val Asp Val Leu Lys Asp Pro Asp Cys Leu Ser Asp Tyr Thr Leu Glu
 305                 310                 315                 320
 Tyr Ser Val Ala Leu Leu Met Asn Leu Cys Leu Arg Ser Thr Gly Lys
                 325                 330                 335    
 Asn Met Cys Ala Lys Val Ala Gly Leu Val Leu Lys Val Leu Ser Asp
             340                 345                 350        
 Leu Leu Gly His Glu Asn His Glu Ile Gln Pro Tyr Val Asn Gly Ala
         355                 360                 365            
 Leu Tyr Ser Ile Leu Ser Val Pro Ser Ile Arg Glu Glu Ala Arg Ala
     370                 375                 380                
 Met Gly Met Glu Asp Ile Leu Arg Cys Phe Ile Lys Glu Gly Asn Ala
 385                 390                 395                 400
 Glu Met Ile Arg Gln Ile Glu Phe Ile Ile Lys Gln Leu Asn Ser Glu
                 405                 410                 415    
 Glu Leu Pro Asp Gly Val Leu Glu Ser Asp Asp Asp Glu Asp Glu Asp
             420                 425                 430        
 Asp Glu Glu Asp His Asp Ile Met Glu Ala Asp Leu Asp Lys Asp Glu
         435                 440                 445            
 Leu Ile Gln Pro Gln Leu Gly Glu Leu Ser Gly Glu Lys Leu Leu Thr
     450                 455                 460                
 Thr Glu Tyr Leu Gly Ile Met Thr Asn Thr Gly Lys Thr Arg Arg Lys
 465                 470                 475                 480
 Gly Leu Ala Asn Val Gln Trp Ser Gly Asp Glu Pro Leu Gln Arg Pro
                 485                 490                 495    
 Val Thr Pro Gly Gly His Arg Asn Gly Tyr Pro Val
             500                 505            



      <210> 661
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 661
 Met Phe Pro Thr Gly Phe Ser Ser Pro Ser Pro Ser Ala Ala Ala Ala
   1               5                  10                  15    
 Ala Gln Glu Val Arg Ser Ala Thr Asp Gly Asn Thr Ser Thr Thr Pro
              20                  25                  30        
 Pro Thr Ser Ala Lys Lys Arg Lys Val Thr Val Val Thr Arg Glu Lys
          35                  40                  45            
 Thr Leu Ile Pro Pro Leu Pro Pro Leu Pro Leu Leu Leu Tyr Asn Pro
      50                  55                  60                
 Gly Ile Arg His Pro Leu Gln Pro Arg Pro Ser Ala Trp Gly Phe Gln
  65                  70                  75                  80
 Trp Leu Leu Pro Ala Thr Tyr Arg Tyr Arg Arg Ser Cys Val Leu Lys
                  85                  90                  95    
 Thr Pro Trp Ser Leu
             100    



      <210> 662
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 662
 Met Asn Ser Asp Ser Leu Gly Pro Pro Cys Pro His Thr Ala Thr Ala
   1               5                  10                  15    
 Ser Gly Ser Arg Pro Ile Ser Ala Pro Ser Gly Gln Pro Gly Leu Met
              20                  25                  30        
 Ala Gln Met Ala Ser Met Ala Ala Gly Val Ala Val Gly Ser Ala Val
          35                  40                  45            
 Gly His Val Met Gly Ser Ala Leu Thr Gly Ala Phe Ser Gly Gly Ser
      50                  55                  60                
 Ser Glu Pro Val Gln Pro Ala Val Gln Gln Ala Pro Thr Pro Ala Ala
  65                  70                  75                  80
 Pro Gln Pro Leu Gln Met Gly Pro Cys Ala Tyr Glu Ile Arg Gln Phe
                  85                  90                  95    
 Leu Asp Cys Ser Thr Thr Gln Ser Asp Leu Ser Leu Cys Glu Gly Phe
             100                 105                 110        
 Ser Glu Ala Leu Lys Gln Cys Lys Tyr Tyr His Gly Leu Ser Ser Leu
         115                 120                 125            
 Pro
    



      <210> 663
      <211> 576
      <212> PRT
      <213> Homo sapiens


      <400> 663
 Met His Pro Ile Pro Ser Ser Phe Met Ile Lys Ala Val Ser Ser Phe
   1               5                  10                  15    
 Leu Thr Ala Glu Glu Ala Ser Val Gly Asn Pro Glu Gly Ala Phe Met
              20                  25                  30        
 Lys Val Leu Gln Ala Arg Lys Asn Tyr Thr Ser Thr Glu Leu Ile Val
          35                  40                  45            
 Glu Pro Glu Glu Pro Ser Asp Ser Ser Gly Ile Asn Leu Ser Gly Phe
      50                  55                  60                
 Gly Ser Glu Gln Leu Asp Thr Asn Asp Glu Ser Asp Phe Ile Ser Thr
  65                  70                  75                  80
 Leu Ser Tyr Ile Leu Pro Tyr Phe Ser Ala Val Asn Leu Asp Val Lys
                  85                  90                  95    
 Ser Leu Leu Leu Pro Leu Ile Lys Leu Pro Thr Thr Gly Asn Ser Leu
             100                 105                 110        
 Ala Lys Ile Gln Thr Val Gly Gln Asn Arg Gln Arg Val Lys Arg Val
         115                 120                 125            
 Leu Met Gly Pro Arg Ser Ile Gln Lys Arg His Phe Lys Glu Val Gly
     130                 135                 140                
 Arg Gln Ser Ile Arg Arg Glu Gln Gly Ala Gln Ala Ser Val Glu Asn
 145                 150                 155                 160
 Ala Ala Glu Glu Lys Arg Leu Gly Ser Pro Ala Pro Arg Glu Val Glu
                 165                 170                 175    
 Gln Pro His Thr Gln Gln Gly Pro Glu Lys Leu Ala Gly Asn Ala Val
             180                 185                 190        
 Tyr Thr Lys Pro Ser Phe Thr Gln Glu His Lys Ala Ala Val Ser Val
         195                 200                 205            
 Leu Lys Pro Phe Ser Lys Gly Ala Pro Ser Thr Ser Ser Pro Ala Lys
     210                 215                 220                
 Ala Leu Pro Gln Val Arg Asp Arg Trp Lys Asp Leu Thr His Ala Ile
 225                 230                 235                 240
 Ser Ile Leu Glu Ser Ala Lys Ala Arg Val Thr Asn Thr Lys Thr Ser
                 245                 250                 255    
 Lys Pro Ile Val His Ala Arg Lys Lys Tyr Arg Phe His Lys Thr Arg
             260                 265                 270        
 Ser His Val Thr His Arg Thr Pro Lys Val Lys Lys Ser Pro Lys Val
         275                 280                 285            
 Arg Lys Lys Ser Tyr Leu Ser Arg Leu Met Leu Ala Asn Arg Leu Pro
     290                 295                 300                
 Phe Ser Ala Ala Lys Ser Leu Ile Asn Ser Pro Ser Gln Gly Ala Phe
 305                 310                 315                 320
 Ser Ser Leu Gly Asp Leu Ser Pro Gln Glu Asn Pro Phe Leu Glu Val
                 325                 330                 335    
 Ser Ala Pro Ser Glu His Phe Ile Glu Asn Asn Asn Thr Lys His Thr
             340                 345                 350        
 Thr Ala Arg Asn Ala Phe Glu Glu Asn Asp Phe Met Glu Asn Thr Asn
         355                 360                 365            
 Met Pro Glu Gly Thr Ile Ser Glu Asn Thr Asn Tyr Asn His Pro His
     370                 375                 380                
 Glu Ala Asp Ser Ala Gly Thr Ala Phe Asn Leu Gly Pro Thr Val Lys
 385                 390                 395                 400
 Gln Thr Glu Thr Lys Trp Glu Tyr Asn Asn Val Gly Thr Asp Leu Ser
                 405                 410                 415    
 Pro Glu Pro Lys Ser Phe Asn Tyr Pro Leu Leu Ser Ser Pro Gly Asp
             420                 425                 430        
 Gln Phe Glu Ile Gln Leu Thr Gln Gln Leu Gln Ser Leu Ile Pro Asn
         435                 440                 445            
 Asn Asn Val Arg Arg Leu Ile Ala His Val Ile Arg Thr Leu Lys Met
     450                 455                 460                
 Asp Cys Ser Gly Ala His Val Gln Val Thr Cys Ala Lys Leu Ile Ser
 465                 470                 475                 480
 Arg Thr Gly His Leu Met Lys Leu Leu Ser Gly Gln Gln Glu Val Lys
                 485                 490                 495    
 Ala Ser Lys Ile Glu Trp Asp Thr Asp Gln Trp Lys Ile Glu Asn Tyr
             500                 505                 510        
 Ile Asn Glu Ser Thr Glu Ala Gln Ser Glu Gln Lys Glu Lys Ser Leu
         515                 520                 525            
 Glu Asp Gly Leu Ser Ser Phe Gly Gln Pro Leu Trp Phe Lys Asp Met
     530                 535                 540                
 Tyr Lys Pro Leu Ser Ala Thr Arg Ile Asn Asn His Ala Trp Lys Leu
 545                 550                 555                 560
 His Lys Lys Ser Ser Asn Glu Asp Glu Ile Leu Asn Arg Asp Pro Gly
                 565                 570                 575    





      <210> 664
      <211> 96
      <212> PRT
      <213> Homo sapiens


      <400> 664
 Met Leu Ser Lys Leu Leu Ala Leu Arg Lys Pro Ala Thr Gly His Val
   1               5                  10                  15    
 Met Lys Thr Ile Gln Lys Thr Val Gln Gln Ile Leu Leu Phe Glu Tyr
              20                  25                  30        
 Ser Ser Asn Arg Ile Tyr Ile Asn Thr Leu Pro Thr Leu Phe Asn Pro
          35                  40                  45            
 Asn Trp Ile Ile His His Ser Leu Lys Met Pro Cys Val Phe Cys Tyr
      50                  55                  60                
 Leu Leu Leu Leu Val Gln Phe Thr Tyr Thr Phe Thr Leu Ser Asn Pro
  65                  70                  75                  80
 Asn Ser Ser Ser Arg Pro Asp Ser Asp Phe Asn Phe Leu Lys Ala Ile
                  85                  90                  95    





      <210> 665
      <211> 104
      <212> PRT
      <213> Homo sapiens


      <400> 665
 Met Pro Arg Ser Ser Gln His Ser Glu Ser Ser Pro Leu Asp Thr Thr
   1               5                  10                  15    
 Thr Gln Arg Lys Gly Ala Ser Ser Leu Ala His Gln Val Arg Val His
              20                  25                  30        
 Thr Leu Glu Thr Leu Leu Asp Trp Pro Glu Leu Pro Gln Pro Leu Leu
          35                  40                  45            
 Thr Pro Pro Pro Val Ile Asp Thr Ala Ala Gly Ser Arg Lys Arg Phe
      50                  55                  60                
 Leu Asn Lys Ala Gln Leu Ala Gln Cys Leu Ala Gln Gln Thr Ile Asn
  65                  70                  75                  80
 Thr Cys Lys Leu Asn Cys Met Ile Leu Ala Gln Val Leu Leu Met Trp
                  85                  90                  95    
 Leu Thr Ala Thr His Leu His Gly
             100                



      <210> 666
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 666
 Met Ala Val Gly Gly Ile Ala Gly Arg Val Val Glu Gly Leu Glu Ile
   1               5                  10                  15    
 Ser Val Val Val Trp Gly Ser Pro Cys Phe Ser Pro Ser Glu Tyr Ala
              20                  25                  30        
 Trp Ile Val Arg Ser Val Thr Met Ala Arg Glu Pro Gly Gln His Glu
          35                  40                  45            
 Leu Leu Ser Leu Lys Phe Arg Gly Leu Leu Gly Phe Pro Glu Leu Arg
      50                  55                  60                
 Ala Asp Val Pro Arg Thr Gln His Gln Glu Thr Pro Val Pro Pro Ala
  65                  70                  75                  80
 Ala Ala Ala Thr Gln Glu Gly Trp Ala Thr Leu Ala Ala Ser His Gln
                  85                  90                  95    
 Leu Pro Leu Leu Ala His Ser Leu Leu Ser Leu Pro Ser Pro Arg Ser
             100                 105                 110        
 Phe Cys Pro Asn His Ala Gly Gly Ser Cys Ser Ala Ser Trp Arg Asp
         115                 120                 125            
 Val His Arg Ala Ser Cys Ala His Pro Cys Ser Lys Gln Leu Asp Ser
     130                 135                 140                
 Phe Pro Ser Thr Pro Thr Leu Val Ser Pro Trp Gly Pro Glu Lys Asp
 145                 150                 155                 160
 Gly Val Pro Ala Pro Ser Gln Leu His Leu
                 165                 170



      <210> 667
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 667
 Met His Gln Ser Pro Thr Leu Pro Glu Leu Gln Ser Ser Leu Leu Asp
   1               5                  10                  15    
 Val Pro Gly Leu Thr Tyr Val Lys Leu Leu Gly Leu Cys Leu Cys Leu
              20                  25                  30        
 Ser Ser Cys Ser Thr Lys Thr Pro His Ser Ser Val Cys Gln Thr Gln
          35                  40                  45            
 Asp Pro Gly Gly Val Gly Ser Gln Leu Asn Arg Leu Met Gln Gly Leu
      50                  55                  60                
 Gln Arg Ser Leu Arg Glu Val Trp Phe Pro Gly Val Ala His Ser Leu
  65                  70                  75                  80
 Thr Ile Phe Leu Gly Trp Gly Gly Gly Ser Phe Gly Ser Val Ser Ile
                  85                  90                  95    
 Leu Gly Gly Thr Ser Lys Ser Ile Leu Met Val Met Pro Tyr Cys Leu
             100                 105                 110        
 Val Ser Ile Thr Phe
         115        



      <210> 668
      <211> 474
      <212> PRT
      <213> Homo sapiens


      <400> 668
 Met Ala Gly Leu Gln Arg Leu Ala Ser His Leu Pro Val Gly Val Met
   1               5                  10                  15    
 Leu Pro His Asn Thr Thr Glu Ala Pro Gly Pro His Ser Ala Lys Gln
              20                  25                  30        
 Asp Ser Tyr Glu Gln Gly Asp Ser Ser Gln Gln Ser Leu Lys Gly His
          35                  40                  45            
 Leu Arg Asn Asn Phe Gln Lys Gln Leu Leu Ser Asn Lys Glu Leu Ile
      50                  55                  60                
 Leu Asp Lys Val Tyr Thr His Pro Lys Trp Asn Thr Gln Thr Lys Ala
  65                  70                  75                  80
 Arg Ser Tyr Ser Tyr Pro His Cys Thr Gly Ile Ser Gln Gln Asp Pro
                  85                  90                  95    
 Glu Ser Asp Ser Gln Gly Gln Gly Asn Gly Leu Phe Tyr Ser Ser Gly
             100                 105                 110        
 Pro Gln Ser Trp Tyr Pro Lys Ala Asn Asn Gln Asp Phe Ile Pro Phe
         115                 120                 125            
 Thr Lys Lys Arg Val Gly Val Asp Arg Ala Phe Pro Leu Lys Pro Met
     130                 135                 140                
 Val His Arg Lys Ser Cys Ser Thr Gly Glu Ala Gly Thr Asp Gly Asp
 145                 150                 155                 160
 His Asn Val Tyr Pro Arg Pro Pro Glu Pro Arg Glu Phe Ser Ser Arg
                 165                 170                 175    
 Asn Phe Gly Val Arg Asn Gln Gly Asn Phe Ser Val Val Gly Thr Val
             180                 185                 190        
 Leu Ala Ala Thr Gln Ala Glu Lys Ala Val Ala Asn Phe Asp Arg Thr
         195                 200                 205            
 Glu Trp Val Gln Ile Arg Arg Leu Glu Ala Ala Gly Glu Ser Leu Glu
     210                 215                 220                
 Glu Glu Ile Arg Arg Lys Gln Ile Leu Leu Arg Gly Lys Leu Lys Lys
 225                 230                 235                 240
 Thr Glu Glu Glu Leu Arg Arg Ile Gln Thr Gln Lys Glu Gln Ala Lys
                 245                 250                 255    
 Glu Asn Glu Asn Gly Glu Leu Gln Lys Ile Ile Leu Pro Arg Ser Arg
             260                 265                 270        
 Val Lys Gly Asn Lys Ser Asn Thr Met Tyr Lys Pro Ile Phe Ser Pro
         275                 280                 285            
 Glu Phe Glu Phe Glu Glu Glu Phe Ser Arg Asp Arg Arg Glu Asp Glu
     290                 295                 300                
 Thr Trp Gly Arg Ser Gln Gln Asn Ser Gly Pro Phe Gln Phe Ser Asp
 305                 310                 315                 320
 Tyr Arg Ile Gln Arg Leu Lys Arg Glu Arg Leu Val Ala Ser Asn Asn
                 325                 330                 335    
 Lys Ile Arg Asp Pro Val Ser Glu Pro Ser Val Glu Lys Phe Ser Pro
             340                 345                 350        
 Pro Ser Glu Thr Pro Val Gly Ala Leu Gln Gly Ser Ala Arg Asn Ser
         355                 360                 365            
 Ser Leu Ser Met Ala Pro Asp Ser Ser Gly Ser Ser Gly Ser Ile Glu
     370                 375                 380                
 Glu Pro Gln Leu Glu Asn Lys Ser Leu Leu Phe Cys Glu Cys Ala Trp
 385                 390                 395                 400
 Val Leu Asn Thr Trp Met His Lys Val Gly Gly Ala Val Gly Ser Tyr
                 405                 410                 415    
 Leu Phe Ser Val Leu Tyr Leu Leu Thr Phe His Tyr Arg Val Leu Pro
             420                 425                 430        
 Ser Thr Glu Pro Leu Arg Phe Cys Trp Glu Ser Gly Leu Pro Leu Ser
         435                 440                 445            
 Ser Thr Ser Phe Ala Gly Pro Trp Phe Ala Ser Thr Leu Ala Ser Gln
     450                 455                 460                
 Leu Leu Leu Leu Leu Leu Ser Cys Ser Leu
 465                 470                



      <210> 669
      <211> 933
      <212> PRT
      <213> Homo sapiens


      <400> 669
 Met Glu Lys Glu Cys Met Asn Gly Cys Val Gln Arg Thr Lys Ala Ala
   1               5                  10                  15    
 Val Glu Phe Pro Gln Lys Thr Ser Ala Leu Ala Val Cys Phe Cys Phe
              20                  25                  30        
 Leu His His Gly Phe Arg Thr Thr Pro Ile Pro Ala Ser Pro Leu Ile
          35                  40                  45            
 Pro Arg Ser Ser Arg Pro Leu His Arg Pro Leu Pro Gly Ile Pro Ile
      50                  55                  60                
 Gly Cys Val Leu Leu Arg Leu Ser Ile Arg Cys Thr Ser Ser Val His
  65                  70                  75                  80
 Gly Cys Pro Leu Ala Leu Cys Asn Thr Cys Leu His Leu Thr Ala Tyr
                  85                  90                  95    
 Ala Pro Val Ser Arg Thr Pro Pro Arg Trp Pro Ser His Trp Leu Pro
             100                 105                 110        
 Ala Pro Ser Gly Pro Ala Pro Ala Gly Pro Ala Ala Gly Ala Val Gly
         115                 120                 125            
 Ala Ala Ala Ala Ala Asp Met Ala Arg Thr Ala Pro Val Glu Pro Pro
     130                 135                 140                
 Leu Arg His Ser Ala Pro Pro Ser Pro Ala Ala Gly Glu Pro Arg Thr
 145                 150                 155                 160
 Ser Val Glu Ala Ala Val Ala Pro Arg Arg Val Leu Phe Ala Asp Glu
                 165                 170                 175    
 Ala Leu Gly Leu Pro Leu Ala Gln Leu Arg Arg Tyr Arg Pro Trp Gly
             180                 185                 190        
 Gly Pro Gly Ala Gly Lys Met Ala Ala Ala Ala Gly Gln Asp Gly Gly
         195                 200                 205            
 Gly Gly Gly Gly Ala Asp Glu Asp Asp Asp Gly Glu Asp Gly Asp Glu
     210                 215                 220                
 Gly Glu Glu Glu Glu Glu Ala Cys Pro Glu Pro Ser Pro Leu Cys Pro
 225                 230                 235                 240
 Val Pro Ala Gly Gly Gly Phe Tyr Leu Val Pro Thr Phe Ser Leu Pro
                 245                 250                 255    
 Pro Ala Pro Gly Arg Leu Glu Arg Leu Gly Arg Val Met Val Glu Leu
             260                 265                 270        
 Glu Ala Leu Leu Pro Pro Pro Gly Ala Val Pro Gly Gly Ala Gly Val
         275                 280                 285            
 Trp Val Pro Gly Gly Arg Pro Pro Val Leu Arg Gly Leu Val Arg Val
     290                 295                 300                
 Leu Asn Arg Ser Phe Glu Lys Ala Val His Val Arg Ala Ser His Asp
 305                 310                 315                 320
 Gly Trp Ala Ser Phe Cys Asp His Pro Ala Arg Tyr Val Pro Arg Ser
                 325                 330                 335    
 Pro Pro Trp Ala Gly Ala Gly Gly Thr Gly Ala Gly Asp Pro Ile Leu
             340                 345                 350        
 Asp Pro Gly Leu Gly Leu Gly Pro Gly Gln Ala Ser Ala Ser Ser Pro
         355                 360                 365            
 Asp Asp Gly Gly Arg Thr Asp Arg Phe Ala Phe Gln Leu Pro Phe Ala
     370                 375                 380                
 Glu Gly Ala Gly Asp Gly Ala Arg Leu Asp Phe Val Val Arg Tyr Glu
 385                 390                 395                 400
 Thr Pro Glu Gly Thr Phe Trp Ala Asn Asn His Gly Arg Asn Tyr Thr
                 405                 410                 415    
 Val Leu Leu Arg Ile Ala Pro Ala Pro Thr Pro Thr Asp Ala Glu Gly
             420                 425                 430        
 Leu Pro Gln Gln Gln Gln Leu Pro Gln Leu Glu Pro Gln Pro Glu Cys
         435                 440                 445            
 Gln Gly Pro Val Glu Ala Glu Ala Arg Gln Leu Lys Ser Cys Met Lys
     450                 455                 460                
 Pro Val Arg Arg Arg Pro Ala Glu Glu Glu Leu Lys Thr Lys Asn Met
 465                 470                 475                 480
 Asp Asp Asn Thr Phe Ala Met Ala Glu His Pro Asp Val Gln Glu Ser
                 485                 490                 495    
 Val Gly Pro Leu Val Ala Pro Thr Pro Leu Arg Pro Trp Pro Gln Met
             500                 505                 510        
 Thr Leu Gln Val Ser Asp Val Pro Met Thr Gly Asn Pro Ala Glu Glu
         515                 520                 525            
 Gly Asp Val Pro Arg Ser Ser Pro Pro Val Ala Phe Thr Glu Val Leu
     530                 535                 540                
 Gln Ala Pro Ala Ile Arg Ile Pro Pro Ser Ser Pro Leu Cys Gly Leu
 545                 550                 555                 560
 Gly Gly Ser Pro Arg Asp Gln Ala Ser Gly Pro Asp Ala Ser Glu Gly
                 565                 570                 575    
 Ala Thr Gly Pro Phe Leu Glu Pro Ser Gln Gln Gln Ala Glu Ala Thr
             580                 585                 590        
 Trp Gly Val Ser Ser Glu Asn Gly Gly Gly Leu Glu Ala Val Ser Gly
         595                 600                 605            
 Ser Glu Glu Leu Leu Gly Glu Asp Thr Ile Asp Gln Glu Leu Glu Gln
     610                 615                 620                
 Leu Tyr Leu Ser His Leu Ser Arg Leu Arg Ala Ala Val Ala Ala Gly
 625                 630                 635                 640
 Gly Ala Gly Gly Gly Gly Glu Gly Ser Thr Asp Gly Gly Met Ser Pro
                 645                 650                 655    
 Ser His Pro Leu Gly Ile Leu Thr Asp Arg Asp Leu Ile Leu Lys Trp
             660                 665                 670        
 Pro Gly Pro Glu Arg Ala Leu Asn Ser Ala Leu Ala Glu Glu Ile Thr
         675                 680                 685            
 Leu His Tyr Ala Arg Leu Gly Arg Gly Val Glu Leu Ile Lys Asp Thr
     690                 695                 700                
 Glu Asp Pro Asp Asp Glu Gly Glu Gly Glu Glu Gly Leu Ser Val Thr
 705                 710                 715                 720
 Pro Ser Ser Pro Glu Gly Asp Ser Pro Lys Glu Ser Pro Pro Glu Ile
                 725                 730                 735    
 Leu Ser Gly Ala Arg Ser Val Val Ala Thr Met Gly Asp Val Trp Leu
             740                 745                 750        
 Pro Trp Ala Glu Gly Ser Gly Cys Asp Gly Pro Val Val Leu Gly Thr
         755                 760                 765            
 Glu Gly Gln Phe Ile Gly Asp Pro Glu Lys Gly Met Gly Lys Asp Thr
     770                 775                 780                
 Ser Ser Leu His Met Asn Arg Val Ile Ala Gly Val Thr Glu Ser Leu
 785                 790                 795                 800
 Gly Glu Ala Gly Thr Glu Ala Gln Ile Glu Val Thr Ser Glu Trp Ala
                 805                 810                 815    
 Gly Ser Leu Asp Pro Ile Ser Gly Lys Glu Pro Ala Ser Pro Val Leu
             820                 825                 830        
 Leu Gln Gly Gln Asn Pro Thr Leu Leu Ser Pro Leu Gly Ala Glu Val
         835                 840                 845            
 Cys Leu Ser Ser Val Ala Arg Pro His Val Ser Ser Gln Asp Glu Lys
     850                 855                 860                
 Asp Ala Gly Pro Ser Leu Glu Pro Pro Lys Lys Ser Pro Thr Leu Ala
 865                 870                 875                 880
 Val Pro Ala Glu Cys Val Cys Ala Leu Pro Pro Gln Leu Arg Gly Pro
                 885                 890                 895    
 Leu Thr Gln Thr Leu Gly Val Leu Ala Gly Leu Val Val Val Pro Val
             900                 905                 910        
 Ala Leu Asn Ser Gly Val Ser Leu Leu Val Leu Ala Leu Cys Leu Ser
         915                 920                 925            
 Leu Ala Trp Phe Ser
     930            



      <210> 670
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 670
 Met Ile Met Ser Ala Phe Arg Arg Glu Ser Pro Pro Thr Ser Val Pro
   1               5                  10                  15    
 Pro Gln Met Gly Ile Tyr Leu Asp Leu Cys Gly Ser Phe Ser Ala Glu
              20                  25                  30        
 Thr Gly Pro Val Ser Gln Ser Phe Leu Gln Met Leu Ile Gly Val Cys
          35                  40                  45            
 Trp Asn Pro Lys Pro Leu Pro Arg Leu Gln Ala Pro Asp Gly Leu Leu
      50                  55                  60                
 Ser Cys Asn Phe Leu Gly Glu Glu Thr Phe Ser Ser Phe Pro Phe Leu
  65                  70                  75                  80
 Val His Pro Cys Thr Leu Val Leu Ser Gln Pro Leu Pro His Ile Val
                  85                  90                  95    
 Pro Asp Ser Arg Gly Thr Ser Ser Leu His Arg Ala Ala Ala Ala Gly
             100                 105                 110        
 Leu Arg Ala Glu Pro Val Gly Ala Glu Ala Leu Ala Pro Glu Val Gln
         115                 120                 125            
 Pro Leu Ser Leu Gly Pro Leu Gly
     130                 135    



      <210> 671
      <211> 225
      <212> PRT
      <213> Homo sapiens


      <400> 671
 Met Ser Glu Phe Trp Leu Ile Ser Ala Pro Gly Asp Lys Glu Asn Leu
   1               5                  10                  15    
 Gln Ala Leu Glu Arg Met Asn Thr Val Thr Ser Lys Ser Asn Leu Ser
              20                  25                  30        
 Tyr Asn Thr Lys Phe Ala Ile Pro Asp Phe Lys Val Gly Thr Leu Asp
          35                  40                  45            
 Ser Leu Val Gly Leu Ser Asp Glu Leu Gly Lys Leu Asp Thr Phe Ala
      50                  55                  60                
 Glu Ser Leu Ile Arg Arg Met Ala Gln Ser Val Val Glu Val Met Glu
  65                  70                  75                  80
 Asp Ser Lys Gly Lys Val Gln Glu His Leu Leu Ala Asn Gly Val Asp
                  85                  90                  95    
 Leu Thr Ser Phe Val Thr His Phe Glu Trp Asp Met Ala Lys Tyr Pro
             100                 105                 110        
 Val Lys Gln Pro Leu Val Ser Val Val Asp Thr Ile Ala Lys Gln Leu
         115                 120                 125            
 Ala Gln Ile Glu Met Asp Leu Lys Ser Arg Thr Ala Ala Tyr Asn Thr
     130                 135                 140                
 Leu Lys Thr Asn Leu Glu Asn Leu Glu Lys Lys Ser Met Gly Asn Leu
 145                 150                 155                 160
 Phe Thr Arg Thr Leu Ser Asp Ile Val Ser Lys Glu Asp Phe Val Leu
                 165                 170                 175    
 Asp Ser Glu Tyr Leu Val Thr Leu Leu Val Ile Val Pro Lys Pro Asn
             180                 185                 190        
 Tyr Ser Gln Trp Gln Lys Thr Tyr Glu Ser Leu Ser Asp Met Val Val
         195                 200                 205            
 Pro Arg Ser Thr Lys Leu Ile Thr Glu Asp Arg Lys Gly Gly Leu Ser
     210                 215                 220                
 Leu
 225



      <210> 672
      <211> 87
      <212> PRT
      <213> Homo sapiens


      <400> 672
 Met Ala Ala Ser Gly Glu Pro Gln Arg Gln Trp Gln Glu Glu Val Ala
   1               5                  10                  15    
 Ala Val Val Val Val Gly Ser Cys Met Thr Asp Leu Val Arg Leu Val
              20                  25                  30        
 Arg Gly Gln Leu Leu Ser Leu Arg Leu Gly Gly Gly Gly Val Pro Cys
          35                  40                  45            
 Ala Met Arg Pro Val Glu Leu Leu Gly Ala Gly Ser Pro Gly Ile Asp
      50                  55                  60                
 Ser Ala Ser Phe Gly Tyr Glu Leu Gln Val Phe Glu Ala Phe Ser Leu
  65                  70                  75                  80
 Pro Ser Trp His Glu Arg Thr
                  85        



      <210> 673
      <211> 184
      <212> PRT
      <213> Homo sapiens


      <400> 673
 Met Ala Asp His Leu Met Leu Ala Glu Gly Tyr Arg Leu Val Gln Arg
   1               5                  10                  15    
 Pro Pro Ser Ala Ala Ala Ala His Gly Pro His Ala Leu Arg Thr Leu
              20                  25                  30        
 Pro Pro Tyr Ala Gly Pro Gly Leu Asp Ser Gly Leu Arg Pro Arg Gly
          35                  40                  45            
 Ala Pro Leu Gly Pro Pro Pro Pro Arg Gln Pro Gly Ala Leu Ala Tyr
      50                  55                  60                
 Gly Ala Phe Gly Pro Pro Ser Ser Phe Gln Pro Phe Pro Ala Val Pro
  65                  70                  75                  80
 Pro Pro Ala Ala Gly Ile Ala His Leu Gln Pro Val Ala Thr Pro Tyr
                  85                  90                  95    
 Pro Gly Arg Ala Ala Ala Pro Pro Asn Ala Pro Gly Gly Pro Pro Gly
             100                 105                 110        
 Pro Gln Pro Ala Pro Ser Ala Ala Ala Pro Pro Pro Pro Ala His Ala
         115                 120                 125            
 Leu Gly Gly Met Asp Ala Glu Leu Ile Asp Glu Glu Ala Leu Thr Ser
     130                 135                 140                
 Leu Glu Leu Glu Leu Gly Leu His Arg Val Arg Glu Leu Pro Glu Leu
 145                 150                 155                 160
 Phe Leu Gly Gln Ser Glu Phe Asp Cys Phe Ser Asp Leu Gly Ser Ala
                 165                 170                 175    
 Pro Pro Ala Gly Ser Val Ser Cys
             180                



      <210> 674
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 674
 Met Val Asn Pro Arg Cys Asp Thr Cys Asn Ala Val Pro Glu Val Leu
   1               5                  10                  15    
 Val Ser Ser Cys Ser Pro Ile Ser Gly Ser Val Ala Leu Leu Gly Arg
              20                  25                  30        
 Met Arg Gly Glu Pro Val Ser Ile Arg Val Lys Leu Pro His Gly Met
          35                  40                  45            
 Pro Trp Met Pro Gly Leu Pro Gln Pro Gln Gly Pro Ser Pro Met Gly
      50                  55                  60                
 Lys Gly Asp Ser Lys Ser Val Ile Ser Asn Pro His Met Gly His Gln
  65                  70                  75                  80
 Lys Cys Leu Gly Met Ile
                  85    



      <210> 675
      <211> 285
      <212> PRT
      <213> Homo sapiens


      <400> 675
 Met Gly Arg Tyr Ser Gly Lys Cys Ser Lys Glu Glu Phe Ala Gly Arg
   1               5                  10                  15    
 Met Phe Ile Val Glu Arg Ser Gln Leu Thr Pro Arg Glu Thr Ser Cys
              20                  25                  30        
 Ala Gly Gly Tyr Gly Val Lys Val Lys Lys Trp Asn Pro Thr Thr Leu
          35                  40                  45            
 Gly Pro Ile Gln Asp Arg Pro His Ile Val Ile Met Ser Thr Ser Thr
      50                  55                  60                
 Ala Val Lys Val Ala Gly Val Thr Pro Trp Ile His His Ser Trp Leu
  65                  70                  75                  80
 Lys Leu Ala Ala Ala Val Thr Pro Asp Tyr Asp Gln Trp Ile Asn Gln
                  85                  90                  95    
 Gln Asp Pro Asp Cys Pro Thr Arg Ile Asp Leu Arg Arg Ile Pro Thr
             100                 105                 110        
 Thr Ser Lys Lys Asp Asn Cys Pro Ala Leu Thr Thr Leu Glu Ala Ala
         115                 120                 125            
 Glu Asn Ile Ala Gly Ser Leu Gly Ile Ser Ser Cys Tyr Val Arg Gly
     130                 135                 140                
 Gly Thr Asn Met Gly Asn Gln Trp Pro Trp Glu Ala Lys Glu Leu Met
 145                 150                 155                 160
 Pro Gln Asp Asn Phe Thr Ser Leu Asn Pro Ala Ser Glu Pro Thr Ala
                 165                 170                 175    
 Ser Ala Ser Val Trp Leu Leu Lys Thr Ser Ile Ile Gly Lys Tyr Arg
             180                 185                 190        
 Ile Ala Arg Trp Gly Lys Ala Phe Thr Glu Ala Val Gly Glu Ile Thr
         195                 200                 205            
 Cys Leu Gly Gln Gln Tyr Tyr Asp Glu Thr Lys Asn Lys Thr Leu Trp
     210                 215                 220                
 Arg Ser Thr Gln Asn Tyr Ser Tyr Leu Pro Asp Pro Asn Pro Leu Ser
 225                 230                 235                 240
 Pro Phe Ser Thr Leu Ser His Thr Trp His Gln Leu Glu Val Pro Asn
                 245                 250                 255    
 Ala Ser Lys Ala Pro Ser Gly Leu Tyr Trp Ile Cys Gly Ala Trp Ala
             260                 265                 270        
 Tyr Trp Gln Leu Pro Ala Lys Trp Thr Gly Ala Cys Val
         275                 280                 285



      <210> 676
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 676
 Met Glu Asn Leu Tyr Thr Leu Leu Pro Leu Asp Ser Glu Ser Lys Leu
   1               5                  10                  15    
 Arg Gly Val Glu Trp Thr Gly Phe Gln Ala Gln Asn Val Ala Val Pro
              20                  25                  30        
 Asp Ser Leu Phe Leu Ser Ser Leu Ile Leu Lys Pro Tyr Asn Thr Tyr
          35                  40                  45            
 Lys Ser Leu Arg Ser Pro Leu Lys Gly Ile Phe Trp Val Ser Leu Tyr
      50                  55                  60                
 Phe Ser Pro Pro Pro Asn Ser Asp Ser Pro Asp Val Cys His Arg Ala
  65                  70                  75                  80
 Phe Gln Ala Gly Ile Gln Leu Leu Arg Cys Ala Ser Trp His Phe Gly
                  85                  90                  95    
 Asp Thr His Phe Gly Asn Thr Pro Met Gly Phe Arg Gly Phe Leu Arg
             100                 105                 110        
 Leu Trp Arg Lys Leu Phe Pro Trp Ala Ser Leu Ala Ser
         115                 120                 125



      <210> 677
      <211> 222
      <212> PRT
      <213> Homo sapiens


      <400> 677
 Met Gly Glu Gln Arg Ala Ala Leu Pro Pro Ala Pro Lys Glu Cys Thr
   1               5                  10                  15    
 His Pro Asn Val Thr Asn Thr Leu Val Gln Ala Glu Ser Ser Asp Ala
              20                  25                  30        
 Gly Val Arg Leu Arg Trp Gly Arg Gly Leu Thr Ala Arg Pro Asp Ala
          35                  40                  45            
 Ser Ala Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val
      50                  55                  60                
 Asp Asp Cys Gly Gly Ala Phe Thr Met Gly Val Ile Gly Gly Gly Val
  65                  70                  75                  80
 Phe Gln Ala Ile Lys Gly Phe Arg Asn Ala Pro Val Gly Ile Arg His
                  85                  90                  95    
 Arg Leu Arg Gly Ser Ala Asn Ala Val Arg Ile Arg Ala Pro Gln Ile
             100                 105                 110        
 Gly Gly Ser Phe Ala Val Trp Gly Gly Leu Phe Ser Thr Ile Asp Cys
         115                 120                 125            
 Gly Leu Val Arg Leu Arg Gly Lys Glu Asp Pro Trp Asn Ser Ile Thr
     130                 135                 140                
 Ser Gly Ala Leu Thr Gly Ala Val Leu Ala Ala Arg Ser Gly Pro Leu
 145                 150                 155                 160
 Ala Met Val Gly Ser Ala Met Met Gly Gly Ile Leu Leu Ala Leu Ile
                 165                 170                 175    
 Glu Gly Val Gly Ile Leu Leu Thr Arg Tyr Thr Ala Gln Gln Phe Arg
             180                 185                 190        
 Asn Ala Pro Pro Phe Leu Glu Asp Pro Ser Gln Leu Pro Pro Lys Asp
         195                 200                 205            
 Gly Thr Pro Ala Pro Gly Tyr Pro Ser Tyr Gln Gln Tyr His
     210                 215                 220        



      <210> 678
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 678
 Met Gly Glu Gln Arg Ala Ala Leu Pro Pro Ala Pro Lys Glu Cys Thr
   1               5                  10                  15    
 His Pro Asn Val Thr Asn Thr Leu Val Gln Ala Glu Ser Ser Asp Ala
              20                  25                  30        
 Gly Val Arg Leu Arg Trp Gly Arg Gly Leu Thr Ala Arg Pro Asp Ala
          35                  40                  45            
 Ser Ala Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val
      50                  55                  60                
 Asp Asp Cys Gly Gly Ala Phe Thr Met Gly Val Ile Gly Gly Gly Val
  65                  70                  75                  80
 Phe Gln Ala Ile Lys Gly Phe Arg Asn Ala Pro Val Cys Arg Leu Leu
                  85                  90                  95    
 Ser Glu Ala Pro Leu Phe Ile Tyr Ser Cys Ser Arg Ser Val Ser Pro
             100                 105                 110        
 Thr Val Asn Val Ser Ser Glu Arg Ala Glu Ser Arg Pro Thr Leu Phe
         115                 120                 125            
 Met Ala Val Ser Leu His Met Ala Trp Cys Leu Ala His Ile Gly Ile
     130                 135                 140                
 Arg His Arg Leu Arg Gly Ser Ala Asn Ala Val Arg Ile Arg Ala Pro
 145                 150                 155                 160
 Gln Ile Gly Gly Ser Phe Ala Val Trp Gly Gly Leu Phe Ser Thr Ile
                 165                 170                 175    
 Asp Cys Gly Leu Val Arg Leu Arg Gly Lys Glu Asp Pro Trp Asn Ser
             180                 185                 190        
 Ile Thr Ser Gly Ala Leu Thr Gly Ala Val Leu Ala Ala Arg Ser Gly
         195                 200                 205            
 Pro Leu Ala Met Val Gly Ser Ala Met Met Gly Gly Ile Leu Leu Ala
     210                 215                 220                
 Leu Ile Glu Gly Val Gly Ile Leu Leu Thr Arg Tyr Thr Ala Gln Gln
 225                 230                 235                 240
 Phe Arg Asn Ala Pro Pro Phe Leu Glu Asp Pro Ser Gln Leu Pro Pro
                 245                 250                 255    
 Lys Asp Gly Thr Pro Ala Pro Gly Tyr Pro Ser Tyr Gln Gln Tyr His
             260                 265                 270        





      <210> 679
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 679
 Met Ala Asn Ile His Thr Phe Ser Ala Cys Leu Ala Leu Ala Asp Leu
   1               5                  10                  15    
 His Gly Asp Gly Glu Tyr Lys Leu Val Val Gly Asp Leu Gly Pro Gly
              20                  25                  30        
 Gly Gln Gln Pro Arg Leu Lys Val Leu Lys Gly Pro Leu Val Met Thr
          35                  40                  45            
 Glu Ser Pro Leu Pro Ala Leu Pro Ala Ala Ala Ala Thr Phe Leu Met
      50                  55                  60                
 Glu Gln His Glu Pro Arg Thr Pro Ala Leu Ala Leu Ala Ser Gly Pro
  65                  70                  75                  80
 Cys Val Tyr Val Tyr Lys Asn Leu Arg Pro Tyr Phe Lys Phe Ser Leu
                  85                  90                  95    
 Pro Gln Leu Pro Pro Asn Pro Leu Glu Gln Asp Leu Trp Asn Gln Ala
             100                 105                 110        
 Lys Glu Asp Arg Ile Asp Pro Leu Thr Leu Lys Glu Met Leu Glu Ser
         115                 120                 125            
 Ile Arg
     130



      <210> 680
      <211> 67
      <212> PRT
      <213> Homo sapiens


      <400> 680
 Met Val Leu Lys Leu Lys Ile Ile Pro Lys Ile His Gln Leu Thr Asn
   1               5                  10                  15    
 Glu Asn Val Ser Leu Cys Pro Thr Leu Pro Pro Ala Gln Ser Glu Phe
              20                  25                  30        
 Gly Thr Gln Lys Arg Thr Val Tyr Thr Thr His Leu Ser Pro Ser Met
          35                  40                  45            
 Tyr Ser Leu Trp Ala Asp Ala Pro Ile His Gly Asn Pro Leu Thr His
      50                  55                  60                
 Phe Lys Thr
  65        



      <210> 681
      <211> 607
      <212> PRT
      <213> Homo sapiens


      <400> 681
 Met Gln Thr Phe Val Thr Gln Gln Trp Lys Gln Ser Lys Glu Lys Ser
   1               5                  10                  15    
 Asn Cys Leu His Asn Lys Lys Leu Ser Glu Lys Lys Val Lys Ser Pro
              20                  25                  30        
 Leu His Leu Phe Ser Thr Leu Arg Arg Ser Pro Ser Tyr Pro Pro Pro
          35                  40                  45            
 Gly Cys Gly Lys Ser Lys Ser Lys Leu Lys Ser Glu Gln Asp Gly Ile
      50                  55                  60                
 Ser Lys Thr His Lys Leu Leu Arg Arg Thr Cys Ser Ser Thr Val Lys
  65                  70                  75                  80
 Thr Asp Asp Val Cys Val Thr Lys Ser His Arg Thr Phe Gly Arg Ser
                  85                  90                  95    
 Leu Ser Ser Asp Pro Arg Ala Glu Gln Ala Met Thr Ala Ile Lys Ser
             100                 105                 110        
 His Lys Leu Leu Asn Arg Pro Cys Pro Ala Ala Val Lys Ser Glu Glu
         115                 120                 125            
 Cys Leu Thr Leu Lys Ser His Arg Leu Leu Thr Arg Ser Cys Ser Gly
     130                 135                 140                
 Asp Pro Arg Cys Glu His Asn Thr Asn Leu Lys Pro His Lys Leu Leu
 145                 150                 155                 160
 Ser Arg Ser Tyr Ser Ser Asn Leu Arg Met Glu Glu Leu Tyr Gly Leu
                 165                 170                 175    
 Lys Asn His Lys Leu Leu Ser Lys Ser Tyr Ser Ser Ala Pro Lys Ser
             180                 185                 190        
 Ser Lys Thr Glu Leu Phe Lys Glu Pro Asn Ala Glu Gly Arg Arg Leu
         195                 200                 205            
 Ser Leu Thr Ser Gly Leu Ile Gly Ile Leu Thr Pro Ser Ser Ser Ser
     210                 215                 220                
 Ser Ser Gln Leu Ala Pro Asn Gly Ala Lys Cys Ile Pro Val Arg Asp
 225                 230                 235                 240
 Arg Gly Phe Leu Val Gln Thr Ile Glu Phe Ala Glu Gln Arg Ile Pro
                 245                 250                 255    
 Val Leu Asn Glu Tyr Cys Val Val Cys Asp Glu Pro His Val Phe Gln
             260                 265                 270        
 Asn Gly Pro Met Leu Arg Pro Thr Val Cys Glu Arg Glu Leu Cys Val
         275                 280                 285            
 Phe Ala Phe Gln Thr Leu Gly Val Met Asn Glu Ala Ala Asp Glu Ile
     290                 295                 300                
 Ala Thr Gly Ala Gln Val Val Asp Leu Leu Val Ser Met Cys Arg Ser
 305                 310                 315                 320
 Ala Leu Glu Ser Pro Arg Lys Val Val Ile Phe Glu Pro Tyr Pro Ser
                 325                 330                 335    
 Val Val Asp Pro Asn Asp Pro Gln Met Leu Ala Phe Asn Pro Arg Lys
             340                 345                 350        
 Lys Asn Tyr Asp Arg Val Met Lys Ala Leu Asp Ser Ile Thr Ser Ile
         355                 360                 365            
 Arg Glu Met Thr Gln Ala Pro Tyr Leu Glu Ile Lys Lys Gln Met Asp
     370                 375                 380                
 Lys Gln Asp Pro Leu Ala His Pro Leu Leu Gln Trp Val Ile Ser Ser
 385                 390                 395                 400
 Asn Arg Ser His Ile Val Lys Leu Pro Val Asn Arg Gln Leu Lys Phe
                 405                 410                 415    
 Met His Thr Pro His Gln Phe Leu Leu Leu Ser Ser Pro Pro Ala Lys
             420                 425                 430        
 Glu Ser Asn Phe Arg Ala Ala Lys Lys Leu Phe Gly Ser Thr Phe Ala
         435                 440                 445            
 Phe His Gly Ser His Ile Glu Asn Trp His Ser Ile Leu Arg Asn Gly
     450                 455                 460                
 Leu Val Val Ala Ser Asn Thr Arg Leu Gln Leu His Gly Ala Met Tyr
 465                 470                 475                 480
 Gly Ser Gly Ile Tyr Leu Ser Pro Met Ser Ser Ile Ser Phe Gly Tyr
                 485                 490                 495    
 Ser Gly Met Asn Lys Lys Gln Lys Val Ser Ala Lys Asp Glu Pro Ala
             500                 505                 510        
 Ser Ser Ser Lys Ser Ser Asn Thr Ser Gln Ser Gln Lys Lys Gly Gln
         515                 520                 525            
 Gln Ser Gln Phe Leu Gln Ser Arg Asn Leu Lys Cys Ile Ala Leu Cys
     530                 535                 540                
 Glu Val Ile Thr Ser Ser Asp Leu His Lys His Gly Glu Ile Trp Val
 545                 550                 555                 560
 Val Pro Asn Thr Asp His Val Cys Thr Arg Phe Phe Phe Val Tyr Glu
                 565                 570                 575    
 Asp Gly Gln Val Gly Asp Ala Asn Ile Asn Thr Gln Glu Gly Gly Ile
             580                 585                 590        
 His Lys Glu Ile Leu Arg Val Ile Gly Asn Gln Thr Ala Thr Gly
         595                 600                 605        



      <210> 682
      <211> 49
      <212> PRT
      <213> Homo sapiens


      <400> 682
 Met Gly Pro Val Leu Gly Gly Arg Arg Ala Leu Met Gly Pro Asp Ser
   1               5                  10                  15    
 Arg Pro Gly Pro Val Pro Ser Cys Ser Leu Val Leu Leu Thr Pro Leu
              20                  25                  30        
 Ala Pro Leu Pro Leu Thr Ala Arg Glu Ser Leu Cys Pro Cys Pro Pro
          35                  40                  45            
 Ser
    



      <210> 683
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 683
 Met Tyr Leu Gln Glu Ile Arg Lys Gln Thr Phe Gln Met Arg Val Met
   1               5                  10                  15    
 Ile Ser Leu Lys Lys Ile Ser Phe Phe Leu Ser Asn Asn Val Leu Tyr
              20                  25                  30        
 Phe Thr Lys Ser Ser Ile Leu Ser Met Ser Arg Asp Lys Gln Leu Leu
          35                  40                  45            
 Glu Gly Thr Gln Phe Ile Leu Pro Gly Phe Ser Leu Leu Leu Asn His
      50                  55                  60                
 Lys Asn Asp Ser Pro Gln Ser Phe Leu Tyr Arg Arg Leu Leu His Phe
  65                  70                  75                  80
 Ile Thr Val Thr Ala Phe
                  85    



      <210> 684
      <211> 319
      <212> PRT
      <213> Homo sapiens


      <400> 684
 Met Cys Ser Leu Pro Val Pro Arg Glu Pro Leu Arg Arg Val Ala Val
   1               5                  10                  15    
 Thr Gly Gly Thr His Gly Asn Glu Met Ser Gly Val Tyr Leu Ala Arg
              20                  25                  30        
 His Trp Leu His Ala Pro Ala Glu Leu Gln Arg Ala Ser Phe Ser Ala
          35                  40                  45            
 Val Pro Val Leu Ala Asn Pro Ala Ala Thr Ser Gly Cys Arg Arg Tyr
      50                  55                  60                
 Val Asp His Asp Leu Asn Arg Thr Phe Thr Ser Ser Phe Leu Asn Ser
  65                  70                  75                  80
 Arg Pro Thr Pro Asp Asp Pro Tyr Glu Val Thr Arg Ala Arg Glu Leu
                  85                  90                  95    
 Asn Gln Leu Leu Gly Pro Lys Ala Ser Gly Gln Ala Phe Asp Phe Val
             100                 105                 110        
 Leu Asp Leu His Asn Thr Thr Ala Asn Met Gly Thr Cys Leu Ile Ala
         115                 120                 125            
 Lys Ser Ser His Glu Val Phe Ala Met His Leu Cys Arg His Leu Gln
     130                 135                 140                
 Leu Gln Tyr Pro Glu Leu Ser Cys Gln Val Phe Leu Tyr Gln Arg Ser
 145                 150                 155                 160
 Gly Glu Glu Ser Tyr Asn Leu Asp Ser Val Ala Lys Asn Gly Leu Gly
                 165                 170                 175    
 Leu Glu Leu Gly Pro Gln Pro Gln Gly Val Leu Arg Ala Asp Ile Phe
             180                 185                 190        
 Ser Arg Met Arg Thr Leu Val Ala Thr Val Leu Asp Phe Ile Glu Leu
         195                 200                 205            
 Phe Asn Gln Gly Thr Ala Phe Pro Ala Phe Glu Met Glu Ala Tyr Arg
     210                 215                 220                
 Pro Val Gly Val Val Asp Phe Pro Arg Thr Glu Ala Gly His Leu Ala
 225                 230                 235                 240
 Gly Thr Val His Pro Gln Leu Gln Asp Arg Asp Phe Gln Pro Leu Gln
                 245                 250                 255    
 Pro Gly Ala Pro Ile Phe Gln Met Phe Ser Gly Glu Asp Leu Leu Tyr
             260                 265                 270        
 Glu Gly Glu Ser Thr Val Tyr Pro Val Phe Ile Asn Glu Ala Ala Tyr
         275                 280                 285            
 Tyr Glu Lys Gly Val Ala Phe Val Gln Thr Glu Lys Phe Thr Phe Thr
     290                 295                 300                
 Val Pro Ala Met Pro Ala Leu Thr Pro Ala Pro Ser Pro Ala Ser
 305                 310                 315                



      <210> 685
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 685
 Met Gly Lys Gly Ile Pro Leu Asn Asp Gln Asp Arg Ile Pro Trp Leu
   1               5                  10                  15    
 Cys Asn Leu His Asp Ile Leu Leu Arg Asp Val Ala Ser Gly Gln Arg
              20                  25                  30        
 Val Val Leu Ala Cys Ser Ala Leu Lys Lys Thr Tyr Arg Asp Ile Leu
          35                  40                  45            
 Thr Gln Gly Lys Asp Gly Val Ala Leu Lys Cys Glu Glu Ser Gly Lys
      50                  55                  60                
 Glu Ala Lys Gln Ala Glu Met Gln Leu Leu Val Val His Leu Ser Gly
  65                  70                  75                  80
 Ser Phe Glu Val Ile Ser Gly Arg Leu Leu Lys Arg Glu Gly His Phe
                  85                  90                  95    
 Met Pro Pro Glu Leu Leu Gln Ser Gln Phe Glu Thr Leu Glu Pro Pro
             100                 105                 110        
 Ala Ala Pro Glu Asn Phe Ile Gln Ile Ser Val Asp Lys Asn Val Ser
         115                 120                 125            
 Glu Ile Ile Ala Thr Ile Met Glu Thr Leu Lys Met Lys
     130                 135                 140    



      <210> 686
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 686
 Met Phe Val Tyr Ser Pro Asn Leu Ser Asn Ala Lys Gly Trp His Arg
   1               5                  10                  15    
 Gly Gln Cys Gln Ala Val Pro Gly Tyr Tyr Leu Pro Leu Arg Lys Asn
              20                  25                  30        
 Ser Met Gly Leu Pro Ser Ser Ile Pro Arg Leu Val Leu Leu Glu Leu
          35                  40                  45            
 Ile Met Ala Gln Cys Ser Ser Leu Trp Lys Cys Pro Arg Gln Pro Arg
      50                  55                  60                
 His Ser Leu Arg Val Leu Ser Asn Thr Thr Leu Gln Ala Ala Val Thr
  65                  70                  75                  80
 Asn His Gln Ser Ser Ala Glu Ala Ser Ser Leu Cys His Pro Cys Asn
                  85                  90                  95    
 Asp Ser Leu Arg Pro Cys Pro Lys His Ser Gly Leu Ser Asn Thr Gln
             100                 105                 110        
 Asn Cys Asn Val Ile Phe Cys Ser Asn Leu Asn Phe
         115                 120                



      <210> 687
      <211> 46
      <212> PRT
      <213> Homo sapiens


      <400> 687
 Met Lys Ile Asn Tyr Ile Ile Lys Gly Ile Pro Asn Ala Glu Thr Lys
   1               5                  10                  15    
 Met Gln Leu Ser Lys Phe Leu Leu Phe Leu Phe Val Tyr Thr Arg Glu
              20                  25                  30        
 Asn Pro Thr Ser Ala Cys Val Trp Gly Glu Lys Ser Thr Val
          35                  40                  45    



      <210> 688
      <211> 67
      <212> PRT
      <213> Homo sapiens


      <400> 688
 Met Asn Tyr Phe Thr Ser Cys Lys Leu Ser His Ile His Lys Met Asn
   1               5                  10                  15    
 Thr Ile Glu Val Ser Phe Leu Cys Asp Leu Leu Ser Ile Arg Lys Val
              20                  25                  30        
 Arg Arg Leu Leu Ser Ile Ser Ser Leu Leu Ser Ile Leu Asn Cys Met
          35                  40                  45            
 Ala Leu Ile Leu Ser Val Phe Leu Ser Leu Leu Glu Leu Phe Lys Ile
      50                  55                  60                
 Cys Pro Ile
  65        



      <210> 689
      <211> 49
      <212> PRT
      <213> Homo sapiens


      <400> 689
 Met Pro Val Asp Ser Leu Arg Gln Trp Gly Thr Arg Cys Phe Pro Pro
   1               5                  10                  15    
 Leu Val Gly Arg Lys Gln Ser Ala Leu Arg Arg Arg Glu Gly Lys Ala
              20                  25                  30        
 Arg Ala Gly Arg Cys Cys Gly Lys Arg Ser Val Lys Ala Gly Phe Asp
          35                  40                  45            
 Ala
    



      <210> 690
      <211> 286
      <212> PRT
      <213> Homo sapiens


      <400> 690
 Met Leu Phe Ser Trp Ala Met Gln Arg Arg Lys Thr Arg Ala Lys Glu
   1               5                  10                  15    
 Thr Gly Ala Lys Cys Leu Asp Thr Asp Leu Gly Ser Cys Cys Val Pro
              20                  25                  30        
 Gln Lys Gly Tyr His Asn Lys Glu Leu Gly Ala Ala Glu Ala Arg Gly
          35                  40                  45            
 Ala Arg Ser Trp Arg Leu Pro Val Pro Arg Leu Cys Arg Pro His Ser
      50                  55                  60                
 Arg Gly Ala Lys Gly Gly Arg Pro Ala Ser Gly Pro Leu Pro Ser Leu
  65                  70                  75                  80
 Ser Leu Arg Cys Cys Glu Arg Arg Pro Leu Arg Arg Arg Pro Ala Thr
                  85                  90                  95    
 Gly Ala Met Ser Ala Asn Glu Asp Gln Glu Met Glu Leu Glu Ala Leu
             100                 105                 110        
 Arg Ser Ile Tyr Glu Gly Asp Glu Ser Phe Arg Glu Leu Ser Pro Val
         115                 120                 125            
 Ser Phe Gln Tyr Arg Ile Gly Glu Asn Gly Asp Pro Lys Ala Phe Leu
     130                 135                 140                
 Ile Glu Ile Ser Trp Thr Glu Thr Tyr Pro Gln Thr Pro Pro Ile Leu
 145                 150                 155                 160
 Ser Met Asn Ala Phe Phe Asn Asn Thr Ile Ser Ser Ala Val Lys Gln
                 165                 170                 175    
 Ser Ile Leu Ala Lys Leu Gln Glu Ala Val Glu Ala Asn Leu Gly Thr
             180                 185                 190        
 Ala Met Thr Tyr Thr Leu Phe Glu Tyr Ala Lys Asp Asn Lys Glu Gln
         195                 200                 205            
 Phe Met Glu Asn His Asn Pro Ile Asn Ser Ala Thr Ser Ile Ser Asn
     210                 215                 220                
 Ile Ile Ser Ile Glu Thr Pro Asn Thr Ala Pro Ser Ser Lys Lys Lys
 225                 230                 235                 240
 Asp Lys Lys Glu Gln Leu Ser Lys Ala Gln Lys Arg Lys Leu Ala Asp
                 245                 250                 255    
 Lys Thr Asp His Lys Gly Glu Leu Pro Arg Gly Trp Asn Trp Val Asp
             260                 265                 270        
 Val Val Lys His Leu Ser Lys Thr Gly Ser Lys Asp Asp Glu
         275                 280                 285    



      <210> 691
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 691
 Met Cys Arg Cys Gln Ser Leu Lys Ile Arg Cys Val Leu Phe Lys Gly
   1               5                  10                  15    
 Met Cys Asp Lys Pro Ala Val Leu Thr Arg Pro Gly Thr Ser Leu Thr
              20                  25                  30        
 Val His Tyr Thr Ser Val Met Ser Gly Ser Val Ser Leu Val Glu Ile
          35                  40                  45            
 Asn Val Glu Ile Tyr Leu Asn Tyr Ser Tyr Leu Thr Ser Pro Leu Phe
      50                  55                  60                
 Leu Glu Phe Gly Glu Glu Asp Lys
  65                  70        



      <210> 692
      <211> 504
      <212> PRT
      <213> Homo sapiens


      <400> 692
 Met Thr Val Lys Pro Ala Lys Ala Ala Ser Leu Ala Arg Asn Leu Ala
   1               5                  10                  15    
 Lys Arg Arg Arg Thr Tyr Leu Gly Gly Ala Ala Gly Arg Ser Gln Glu
              20                  25                  30        
 Pro Glu Val Pro Cys Ala Ala Val Leu Pro Gly Lys Pro Gly Asp Arg
          35                  40                  45            
 Asn Cys Pro Glu Phe Pro Pro Pro Asp Arg Thr Leu Gly Cys Trp Ala
      50                  55                  60                
 Thr Asp Ala Ala Pro Ala Ala Gly Leu Cys Gly Ala Gly Ser Glu Pro
  65                  70                  75                  80
 Ser Ile Ala Pro Thr Ser Cys Ala Gly Asn Leu Pro Ser Arg Pro Pro
                  85                  90                  95    
 Pro Leu Leu Ser Pro Leu Leu Ala Ser Arg Asn Pro Cys Pro Trp His
             100                 105                 110        
 Tyr Leu His Leu Ser Gly Ser His Asn Thr Leu Ala Pro Thr Cys Phe
         115                 120                 125            
 Lys Ala Lys Leu His Arg Lys Arg Gly Ser Gln Pro Pro Asp Met Ala
     130                 135                 140                
 Ser Ala Leu Thr Asp Arg Thr Ser Arg Ala Pro Ser Thr Tyr Thr Tyr
 145                 150                 155                 160
 Thr Ser Arg Pro Arg Ala Leu Pro Cys Gln Arg Ser Arg Tyr Arg Asp
                 165                 170                 175    
 Ser Leu Thr Gln Pro Asp Glu Glu Pro Met His Tyr Gly Asn Ile Met
             180                 185                 190        
 Tyr Asp Arg Arg Val Ile Arg Gly Asn Thr Tyr Ala Leu Gln Thr Gly
         195                 200                 205            
 Pro Leu Leu Gly Arg Pro Asp Ser Leu Glu Leu Gln Arg Gln Arg Glu
     210                 215                 220                
 Ala Arg Lys Arg Ala Leu Ala Arg Lys Gln Ala Gln Glu Gln Leu Arg
 225                 230                 235                 240
 Pro Gln Thr Pro Glu Pro Val Glu Gly Arg Lys His Val Asp Val Gln
                 245                 250                 255    
 Thr Val Lys Pro Val Leu Glu Val Leu Val Gly Lys Thr Ile Glu Gln
             260                 265                 270        
 Ser Leu Leu Glu Val Met Glu Glu Glu Glu Leu Ala Asn Leu Arg Ala
         275                 280                 285            
 Ser Gln Arg Glu Tyr Glu Glu Leu Arg Asn Ser Glu Arg Ala Glu Val
     290                 295                 300                
 Gln Arg Leu Glu Glu Gln Glu Arg Arg His Arg Glu Glu Lys Glu Arg
 305                 310                 315                 320
 Arg Lys Lys Gln Gln Trp Glu Ile Met His Lys His Asn Glu Thr Ser
                 325                 330                 335    
 Gln Lys Ile Ala Ala Arg Ala Phe Ala Gln Arg Tyr Leu Ala Asp Leu
             340                 345                 350        
 Leu Pro Ser Val Phe Gly Ser Leu Arg Asp Ser Gly Tyr Phe Tyr Asp
         355                 360                 365            
 Pro Ile Glu Arg Asp Ile Glu Ile Gly Phe Leu Pro Trp Leu Met Asn
     370                 375                 380                
 Glu Val Glu Lys Thr Met Glu Tyr Ser Met Val Gly Arg Thr Val Leu
 385                 390                 395                 400
 Asp Met Leu Ile Arg Glu Val Val Glu Lys Arg Leu Cys Met Tyr Glu
                 405                 410                 415    
 His Gly Glu Asp Thr His Gln Ser Pro Glu Pro Glu Asp Glu Pro Gly
             420                 425                 430        
 Gly Pro Gly Ala Met Thr Glu Ser Leu Glu Ala Ser Glu Phe Leu Glu
         435                 440                 445            
 Gln Ser Met Ser Gln Thr Arg Glu Leu Leu Leu Asp Gly Gly Tyr Leu
     450                 455                 460                
 Gln Arg Thr Thr Tyr Asp Arg Arg Ser Ser Gln Glu Arg Lys Phe Met
 465                 470                 475                 480
 Glu Glu Arg Glu Leu Leu Gly Gln Asp Glu Glu Thr Ala Met Arg Lys
                 485                 490                 495    
 Ser Leu Gly Glu Glu Glu Leu Ser
             500                



      <210> 693
      <211> 560
      <212> PRT
      <213> Homo sapiens


      <400> 693
 Met Thr Val Lys Pro Ala Lys Ala Ala Ser Leu Ala Arg Asn Leu Ala
   1               5                  10                  15    
 Lys Arg Arg Arg Thr Tyr Leu Gly Gly Ala Ala Gly Arg Ser Gln Glu
              20                  25                  30        
 Pro Glu Val Pro Cys Ala Ala Val Leu Pro Gly Lys Pro Gly Asp Arg
          35                  40                  45            
 Asn Cys Pro Glu Phe Pro Pro Pro Asp Arg Thr Leu Gly Cys Trp Ala
      50                  55                  60                
 Thr Asp Ala Ala Pro Ala Ala Gly Leu Cys Gly Ala Gly Ser Glu Pro
  65                  70                  75                  80
 Ser Ile Ala Pro Thr Ser Cys Ala Gly Asn Leu Pro Ser Arg Pro Pro
                  85                  90                  95    
 Pro Leu Leu Ser Pro Leu Leu Ala Ser Arg Asn Pro Cys Pro Trp His
             100                 105                 110        
 Tyr Leu His Leu Ser Gly Ser His Asn Thr Leu Ala Pro Thr Cys Phe
         115                 120                 125            
 Lys Ala Lys Leu His Arg Lys Arg Gly Ser Gln Pro Pro Asp Met Ala
     130                 135                 140                
 Ser Ala Leu Thr Asp Arg Thr Ser Arg Ala Pro Ser Thr Tyr Thr Tyr
 145                 150                 155                 160
 Thr Ser Arg Pro Arg Ala Leu Pro Cys Gln Arg Ser Arg Tyr Arg Asp
                 165                 170                 175    
 Ser Leu Thr Gln Pro Asp Glu Glu Pro Met His Tyr Gly Asn Ile Met
             180                 185                 190        
 Tyr Asp Arg Arg Val Ile Arg Gly Asn Thr Tyr Ala Leu Gln Thr Gly
         195                 200                 205            
 Pro Leu Leu Gly Arg Pro Asp Ser Leu Glu Leu Gln Arg Gln Arg Glu
     210                 215                 220                
 Ala Arg Lys Arg Ala Leu Ala Arg Lys Gln Ala Gln Glu Gln Leu Arg
 225                 230                 235                 240
 Pro Gln Thr Pro Glu Pro Val Glu Gly Arg Lys His Val Asp Val Gln
                 245                 250                 255    
 Thr Glu Leu Tyr Leu Glu Glu Ile Ala Asp Arg Ile Ile Glu Val Asp
             260                 265                 270        
 Met Glu Cys Gln Thr Asp Ala Phe Leu Asp Arg Pro Pro Thr Pro Leu
         275                 280                 285            
 Phe Ile Pro Ala Lys Thr Gly Lys Asp Val Ala Thr Gln Ile Leu Glu
     290                 295                 300                
 Gly Glu Leu Phe Asp Phe Asp Leu Glu Val Lys Pro Val Leu Glu Val
 305                 310                 315                 320
 Leu Val Gly Lys Thr Ile Glu Gln Ser Leu Leu Glu Val Met Glu Glu
                 325                 330                 335    
 Glu Glu Leu Ala Asn Leu Arg Ala Ser Gln Arg Glu Tyr Glu Glu Leu
             340                 345                 350        
 Arg Asn Ser Glu Arg Ala Glu Val Gln Arg Leu Glu Glu Gln Glu Arg
         355                 360                 365            
 Arg His Arg Glu Glu Lys Glu Arg Arg Lys Lys Gln Gln Trp Glu Ile
     370                 375                 380                
 Met His Lys His Asn Glu Thr Ser Gln Lys Ile Ala Ala Arg Ala Phe
 385                 390                 395                 400
 Ala Gln Arg Tyr Leu Ala Asp Leu Leu Pro Ser Val Phe Gly Ser Leu
                 405                 410                 415    
 Arg Asp Ser Gly Tyr Phe Tyr Asp Pro Ile Glu Arg Asp Ile Glu Ile
             420                 425                 430        
 Gly Phe Leu Pro Trp Leu Met Asn Glu Val Glu Lys Thr Met Glu Tyr
         435                 440                 445            
 Ser Met Val Gly Arg Thr Val Leu Asp Met Leu Ile Arg Glu Val Val
     450                 455                 460                
 Glu Lys Arg Leu Cys Met Tyr Glu His Gly Glu Asp Thr His Gln Ser
 465                 470                 475                 480
 Pro Glu Pro Glu Asp Glu Pro Gly Gly Pro Gly Ala Met Thr Glu Ser
                 485                 490                 495    
 Leu Glu Ala Ser Glu Phe Leu Glu Gln Ser Met Ser Gln Thr Arg Glu
             500                 505                 510        
 Leu Leu Leu Asp Gly Gly Tyr Leu Gln Arg Thr Thr Tyr Asp Arg Arg
         515                 520                 525            
 Ser Ser Gln Glu Arg Lys Phe Met Glu Glu Arg Glu Leu Leu Gly Gln
     530                 535                 540                
 Asp Glu Glu Thr Ala Met Arg Lys Ser Leu Gly Glu Glu Glu Leu Ser
 545                 550                 555                 560





      <210> 694
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 694
 Met Tyr Cys Lys Ile Leu Val Leu Met Leu His Thr Glu Leu Ile Arg
   1               5                  10                  15    
 Thr Asp Tyr Ser Ser Val Asp Gln Leu Leu Leu Asn Tyr Pro Ala Glu
              20                  25                  30        
 Glu Gly Leu Gly Arg Glu Arg Ser Leu Leu Trp Thr Pro Leu Leu Ser
          35                  40                  45            
 Pro Gly Ser Leu Arg Val Ile Leu Glu Ser Arg Glu Val Pro Val Ser
      50                  55                  60                
 Leu Trp Pro Gln Thr Leu Arg Pro Ser Gln Lys Leu Phe Thr Lys Val
  65                  70                  75                  80
 Gln Asn His Leu Ser Ala Phe His Thr Ser Phe Pro Met His Gly Ser
                  85                  90                  95    
 Lys Thr Phe
            



      <210> 695
      <211> 77
      <212> PRT
      <213> Homo sapiens


      <400> 695
 Met Asp Ala Glu Val Gly Trp Gln Pro Ser Ala Arg Leu Pro Gly Ser
   1               5                  10                  15    
 Arg Val Glu Ala Ile Pro Thr Glu Ser Ile Trp Leu Val Pro Val Phe
              20                  25                  30        
 Leu Leu Pro Ala Lys Leu Gly Phe Arg Pro Ser Ala Asp Ser Val Pro
          35                  40                  45            
 His Val Leu Gly Ala Leu Asp Ile Pro Gly Ser Gly Ala Tyr Glu Ala
      50                  55                  60                
 Leu Trp Pro Lys Val Pro Glu Val Leu Leu Val Pro Ile
  65                  70                  75        



      <210> 696
      <211> 362
      <212> PRT
      <213> Homo sapiens


      <400> 696
 Met Ile Leu Arg Val Thr Leu Arg Asn Pro Gly Ser Ser Gly Arg Lys
   1               5                  10                  15    
 Glu Arg Pro Glu Thr Gly Thr Gly Ser Trp Leu Gly Arg Thr Arg Asn
              20                  25                  30        
 Gln Val Ile Asn Thr Leu Ala Asp His Arg His Arg Gly Thr Asp Phe
          35                  40                  45            
 Gly Gly Ser Pro Trp Leu Leu Ile Ile Thr Val Phe Leu Arg Ser Tyr
      50                  55                  60                
 Lys Phe Ala Ile Ser Leu Cys Thr Ser Tyr Leu Cys Val Ser Phe Leu
  65                  70                  75                  80
 Lys Thr Ile Phe Pro Ser Gln Asn Gly His Asp Gly Ser Thr Asp Val
                  85                  90                  95    
 Gln Gln Arg Ala Arg Arg Ser Asn Cys Arg Arg Gln Glu Gly Ile Lys
             100                 105                 110        
 Ile Val Leu Glu Asp Ile Phe Thr Leu Trp Arg Gln Val Glu Thr Lys
         115                 120                 125            
 Val Arg Ala Lys Ile Arg Lys Met Lys Val Thr Thr Lys Val Asn Arg
     130                 135                 140                
 His Asp Lys Ile Asn Gly Lys Arg Lys Thr Ala Lys Glu His Leu Arg
 145                 150                 155                 160
 Lys Leu Ser Met Lys Glu Arg Glu His Gly Glu Lys Glu Arg Gln Val
                 165                 170                 175    
 Ser Glu Ala Glu Glu Asn Gly Lys Leu Asp Met Lys Glu Ile His Thr
             180                 185                 190        
 Tyr Met Glu Met Phe Gln Arg Ala Gln Ala Leu Arg Arg Arg Ala Glu
         195                 200                 205            
 Asp Tyr Tyr Arg Cys Lys Ile Thr Pro Ser Ala Arg Lys Pro Leu Cys
     210                 215                 220                
 Asn Arg Val Arg Met Ala Ala Val Glu His Arg His Ser Ser Gly Leu
 225                 230                 235                 240
 Pro Tyr Trp Pro Tyr Leu Thr Ala Glu Thr Leu Lys Asn Arg Met Gly
                 245                 250                 255    
 His Gln Pro Pro Pro Pro Thr Gln Gln His Ser Ile Ile Asp Asn Ser
             260                 265                 270        
 Leu Ser Leu Lys Thr Pro Ser Glu Cys Leu Leu Thr Pro Leu Pro Pro
         275                 280                 285            
 Ser Ala Leu Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ala Glu Cys
     290                 295                 300                
 Leu Leu Tyr Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro
 305                 310                 315                 320
 Pro Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala
                 325                 330                 335    
 Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys Val Cys Ser Leu Pro Phe
             340                 345                 350        
 His Pro Gln Arg Met Ile Ile Ser Arg Asn
         355                 360        



      <210> 697
      <211> 381
      <212> PRT
      <213> Homo sapiens


      <400> 697
 Met Ile Leu Arg Val Thr Leu Arg Asn Pro Gly Ser Ser Gly Arg Lys
   1               5                  10                  15    
 Glu Arg Pro Glu Thr Gly Thr Gly Ser Trp Leu Gly Arg Thr Arg Asn
              20                  25                  30        
 Gln Val Ile Asn Thr Leu Ala Asp His Arg His Arg Gly Thr Asp Phe
          35                  40                  45            
 Gly Gly Ser Pro Trp Leu Leu Ile Ile Thr Val Phe Leu Arg Ser Tyr
      50                  55                  60                
 Lys Phe Ala Ile Ser Leu Cys Thr Ser Tyr Leu Cys Val Ser Phe Leu
  65                  70                  75                  80
 Lys Thr Ile Phe Pro Ser Gln Asn Gly His Asp Gly Ser Thr Asp Val
                  85                  90                  95    
 Gln Gln Arg Ala Arg Arg Ser Asn Cys Arg Arg Gln Glu Gly Ile Lys
             100                 105                 110        
 Ile Val Leu Glu Asp Ile Phe Thr Leu Trp Arg Gln Val Glu Thr Lys
         115                 120                 125            
 Val Arg Ala Lys Ile Arg Lys Met Lys Val Thr Thr Lys Val Asn Arg
     130                 135                 140                
 His Asp Lys Ile Asn Gly Lys Arg Lys Thr Ala Lys Glu His Leu Arg
 145                 150                 155                 160
 Lys Leu Ser Met Lys Glu Arg Glu His Gly Glu Lys Glu Arg Gln Val
                 165                 170                 175    
 Ser Glu Ala Glu Glu Asn Gly Lys Leu Asp Met Lys Glu Ile His Thr
             180                 185                 190        
 Tyr Met Glu Met Phe Gln Arg Ala Gln Ala Leu Arg Arg Arg Ala Glu
         195                 200                 205            
 Asp Tyr Tyr Arg Cys Lys Ile Thr Pro Ser Ala Arg Lys Pro Leu Cys
     210                 215                 220                
 Asn Arg Val Arg Met Ala Ala Val Glu His Arg His Ser Ser Gly Leu
 225                 230                 235                 240
 Pro Tyr Trp Pro Tyr Leu Thr Ala Glu Thr Leu Lys Asn Arg Met Gly
                 245                 250                 255    
 His Gln Pro Pro Pro Pro Thr Gln Gln His Ser Ile Ile Asp Asn Ser
             260                 265                 270        
 Leu Ser Leu Lys Thr Pro Ser Glu Cys Val Leu Tyr Pro Leu Pro Pro
         275                 280                 285            
 Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys Leu Leu Thr Pro
     290                 295                 300                
 Leu Pro Pro Ser Ala Leu Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro
 305                 310                 315                 320
 Ala Glu Cys Leu Leu Tyr Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu
                 325                 330                 335    
 Lys Thr Pro Pro Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Pro
             340                 345                 350        
 Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys Val Cys Ser
         355                 360                 365            
 Leu Pro Phe His Pro Gln Arg Met Ile Ile Ser Arg Asn
     370                 375                 380    



      <210> 698
      <211> 339
      <212> PRT
      <213> Homo sapiens


      <400> 698
 Met Ile Leu Arg Val Thr Leu Arg Asn Pro Gly Ser Ser Gly Arg Lys
   1               5                  10                  15    
 Glu Arg Pro Glu Thr Gly Thr Gly Ser Trp Leu Gly Arg Thr Arg Asn
              20                  25                  30        
 Gln Val Ile Asn Thr Leu Ala Asp His Arg His Arg Gly Thr Asp Phe
          35                  40                  45            
 Gly Gly Ser Pro Trp Leu Leu Ile Ile Thr Val Phe Leu Arg Ser Tyr
      50                  55                  60                
 Lys Phe Ala Ile Ser Leu Cys Thr Ser Tyr Leu Cys Val Ser Phe Leu
  65                  70                  75                  80
 Lys Thr Ile Phe Pro Ser Gln Asn Gly His Asp Gly Ser Thr Asp Val
                  85                  90                  95    
 Gln Gln Arg Ala Arg Arg Ser Asn Cys Arg Arg Gln Glu Gly Ile Lys
             100                 105                 110        
 Ile Val Leu Glu Asp Ile Phe Thr Leu Trp Arg Gln Val Glu Thr Lys
         115                 120                 125            
 Val Arg Ala Lys Ile Arg Lys Met Lys Val Thr Thr Lys Val Asn Arg
     130                 135                 140                
 His Asp Lys Ile Asn Gly Lys Arg Lys Thr Ala Lys Glu His Leu Arg
 145                 150                 155                 160
 Lys Leu Ser Met Lys Glu Arg Glu His Gly Glu Lys Glu Arg Gln Val
                 165                 170                 175    
 Ser Glu Ala Glu Glu Asn Gly Lys Leu Asp Met Lys Glu Ile His Thr
             180                 185                 190        
 Tyr Met Glu Met Phe Gln Arg Ala Gln Ala Leu Arg Arg Arg Ala Glu
         195                 200                 205            
 Asp Tyr Tyr Arg Cys Lys Ile Thr Pro Ser Ala Arg Lys Pro Leu Cys
     210                 215                 220                
 Asn Arg Val Arg Met Ala Ala Val Glu His Arg His Ser Ser Gly Leu
 225                 230                 235                 240
 Pro Tyr Trp Pro Tyr Leu Thr Ala Glu Thr Leu Lys Asn Arg Met Gly
                 245                 250                 255    
 His Gln Pro Pro Pro Pro Thr Gln Gln His Ser Ile Ile Asp Asn Ser
             260                 265                 270        
 Leu Ser Leu Lys Thr Pro Ala Glu Cys Leu Leu Tyr Pro Leu Pro Pro
         275                 280                 285            
 Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys Leu Leu Thr Pro
     290                 295                 300                
 Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro
 305                 310                 315                 320
 Pro Glu Cys Val Cys Ser Leu Pro Phe His Pro Gln Arg Met Ile Ile
                 325                 330                 335    
 Ser Arg Asn
            



      <210> 699
      <211> 326
      <212> PRT
      <213> Homo sapiens


      <400> 699
 Met Ile Leu Arg Val Thr Leu Arg Asn Pro Gly Ser Ser Gly Arg Lys
   1               5                  10                  15    
 Glu Arg Pro Glu Thr Gly Thr Gly Ser Trp Leu Gly Arg Thr Arg Asn
              20                  25                  30        
 Gln Val Ile Asn Thr Leu Ala Asp His Arg His Arg Gly Thr Asp Phe
          35                  40                  45            
 Gly Gly Ser Pro Trp Leu Leu Ile Ile Thr Val Phe Leu Arg Ser Tyr
      50                  55                  60                
 Lys Phe Ala Ile Ser Leu Cys Thr Ser Tyr Leu Cys Val Ser Phe Leu
  65                  70                  75                  80
 Lys Thr Ile Phe Pro Ser Gln Asn Gly His Asp Gly Ser Thr Asp Val
                  85                  90                  95    
 Gln Gln Arg Ala Arg Arg Ser Asn Cys Arg Arg Gln Glu Gly Ile Lys
             100                 105                 110        
 Ile Val Leu Glu Asp Ile Phe Thr Leu Trp Arg Gln Val Glu Thr Lys
         115                 120                 125            
 Val Arg Ala Lys Ile Arg Lys Met Lys Val Thr Thr Lys Val Asn Arg
     130                 135                 140                
 His Asp Lys Ile Asn Gly Lys Arg Lys Thr Ala Lys Glu Gln Glu Met
 145                 150                 155                 160
 Phe Gln Arg Ala Gln Ala Leu Arg Arg Arg Ala Glu Asp Tyr Tyr Arg
                 165                 170                 175    
 Cys Lys Ile Thr Pro Ser Ala Arg Lys Pro Leu Cys Asn Arg Val Arg
             180                 185                 190        
 Met Ala Ala Val Glu His Arg His Ser Ser Gly Leu Pro Tyr Trp Pro
         195                 200                 205            
 Tyr Leu Thr Ala Glu Thr Leu Lys Asn Arg Met Gly His Gln Pro Pro
     210                 215                 220                
 Pro Pro Thr Gln Gln His Ser Ile Ile Asp Asn Ser Leu Ser Leu Lys
 225                 230                 235                 240
 Thr Pro Ser Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Leu Pro
                 245                 250                 255    
 Ser Ala Asp Asp Asn Leu Lys Thr Pro Ala Glu Cys Leu Leu Tyr Pro
             260                 265                 270        
 Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys Leu
         275                 280                 285            
 Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Leu
     290                 295                 300                
 Lys Thr Pro Pro Glu Cys Val Cys Ser Leu Pro Phe His Pro Gln Arg
 305                 310                 315                 320
 Met Ile Ile Ser Arg Asn
                 325    



      <210> 700
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 700
 Met Glu Pro Asn Ser Pro Lys Lys Ile Gln Phe Ala Val Pro Val Phe
   1               5                  10                  15    
 Gln Ser Gln Ile Ala Pro Glu Ala Ala Glu Gln Ile Arg Lys Arg Arg
              20                  25                  30        
 Pro Thr Pro Ala Ser Leu Val Ile Leu Asn Glu His Asn Pro Pro Glu
          35                  40                  45            
 Ile Asp Asp Lys Arg Gly Pro Asn Thr Gln Gly Glu Leu Gln Asn Ala
      50                  55                  60                
 Ser Pro Lys Gln Arg Lys Gln Ser Val Tyr Thr Pro Pro Thr Ile Lys
  65                  70                  75                  80
 Gly Val Lys His Leu Lys Gly Gln Asn Glu Ser Ala Phe Pro Glu Glu
                  85                  90                  95    
 Glu Glu Gly Thr Asn Glu Arg Glu Glu Gln Arg Asp His
             100                 105                



      <210> 701
      <211> 370
      <212> PRT
      <213> Homo sapiens


      <400> 701
 Met Pro Thr Glu Thr Leu Gln Thr Gly Ser Met Val Lys Pro Val Ser
   1               5                  10                  15    
 Pro Ala Gly Thr Phe Thr Ser Ala Val Pro Leu Arg Ile Leu Asn Lys
              20                  25                  30        
 Gly Pro Asp Tyr Phe Arg Arg Gln Ala Glu Pro Asn Pro Lys Arg Leu
          35                  40                  45            
 Ser Ala Val Glu Arg Leu Glu Ala Asp Lys Ala Lys Tyr Val Lys Ser
      50                  55                  60                
 Gln Glu Val Ile Asn Ala Lys Gln Glu Pro Val Lys Pro Ala Val Leu
  65                  70                  75                  80
 Ala Lys Pro Pro Val Cys Pro Ala Ala Lys Arg Ala Leu Gly Ser Pro
                  85                  90                  95    
 Thr Leu Lys Val Phe Gly Asn His Ala Lys Thr Glu Ser Gly Val Gln
             100                 105                 110        
 Arg Glu Asn Leu Lys Leu Glu Ile Leu Lys Asn Ile Ile Asn Ser Ser
         115                 120                 125            
 Glu Gly Ser Ser Ser Gly Ser Gly His Lys His Ser Ser Arg Asn Trp
     130                 135                 140                
 Pro Pro His Arg Ser Glu Ala Thr Asp Leu His Arg His Ser Phe Ala
 145                 150                 155                 160
 Glu Ser Leu Lys Val Tyr Pro Thr Gln Gly Arg Arg Ser Pro Gln Glu
                 165                 170                 175    
 Gly Gly Ser His Val Gly Arg Arg Leu Leu Glu Gln Ser Ala Glu Ser
             180                 185                 190        
 Phe Leu His Val Ser His Ser Ser Ser Asp Ile Arg Lys Val Thr Ser
         195                 200                 205            
 Val Lys Pro Leu Lys Ala Ile Pro Cys Ser Ser Ser Ala Pro Pro Leu
     210                 215                 220                
 Pro Pro Lys Pro Lys Ile Ala Ala Ile Ala Ser Met Lys Ser Pro Glu
 225                 230                 235                 240
 Ala Asp Pro Val Glu Pro Ala Cys Gly Val Ser Arg Arg Pro Ser Leu
                 245                 250                 255    
 Gln Arg Ser Lys Ser Asp Leu Ser Asp Arg Tyr Phe Arg Val Asp Ala
             260                 265                 270        
 Asp Val Glu Arg Phe Phe Asn Tyr Cys Gly Leu Asp Pro Glu Glu Leu
         275                 280                 285            
 Glu Asn Leu Gly Met Glu Asn Phe Ala Arg Ala Asn Ser Asp Ile Ile
     290                 295                 300                
 Ser Leu Asn Phe Arg Ser Ala Ser Met Ile Ser Ser Asp Cys Glu Gln
 305                 310                 315                 320
 Ser Gln Asp Ser Asn Ser Asp Leu Arg Asn Asp Asp Ser Ala Asn Asp
                 325                 330                 335    
 Arg Val Pro Tyr Gly Ile Ser Ala Ile Glu Arg Asn Ala Arg Ile Ile
             340                 345                 350        
 Lys Trp Leu Tyr Ser Ile Lys Gln Ala Arg Glu Ser Gln Lys Val Ser
         355                 360                 365            
 His Val
     370



      <210> 702
      <211> 207
      <212> PRT
      <213> Homo sapiens


      <400> 702
 Met Cys Arg Leu Lys Arg Gln Glu Phe Val Ile Ser Arg Ala Gln Thr
   1               5                  10                  15    
 Val Thr Ser Asp Gln Glu Lys Arg Leu Leu His Gln Leu Arg Glu Ile
              20                  25                  30        
 Thr Arg Val Met Lys Glu Gly Lys Phe Ile Asp Arg Phe Ser Pro Glu
          35                  40                  45            
 Lys Glu Ala Glu Glu Ala Pro Tyr Met Glu Asp Trp Glu Gly Tyr Pro
      50                  55                  60                
 Glu Glu Thr Tyr Pro Ile Tyr Asp Leu Ser Asp Cys Ile Lys Arg Arg
  65                  70                  75                  80
 Gln Glu Thr Ile Leu Val Asp Tyr Pro Asp Pro Lys Glu Leu Ser Ala
                  85                  90                  95    
 Glu Glu Ile Ala Glu Arg Met Gly Met Ile Glu Glu Glu Glu Ser Asp
             100                 105                 110        
 His Leu Gly Trp Glu Ser Leu Pro Thr Asp Pro Arg Ala Gln Glu Asp
         115                 120                 125            
 Asn Ser Val Thr Ser Cys Asp Pro Lys Pro Glu Thr Cys Ser Cys Cys
     130                 135                 140                
 Phe His Glu Asp Glu Asp Pro Ala Val Leu Ala Glu Asn Ala Gly Phe
 145                 150                 155                 160
 Ser Ala Asp Ser Tyr Pro Glu Gln Glu Glu Thr Thr Lys Glu Glu Trp
                 165                 170                 175    
 Ser Gln Asp Phe Lys Asp Glu Gly Leu Gly Ile Ser Thr Asp Lys Ala
             180                 185                 190        
 Tyr Thr Gly Ser Met Leu Arg Lys Arg Asn Pro Gln Gly Leu Glu
         195                 200                 205        



      <210> 703
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 703
 Met Pro Leu Pro Val Gly Phe Trp Met Gly Ser Leu Pro Pro Pro Trp
   1               5                  10                  15    
 Cys Trp Arg Lys Trp Val Ser Glu Ala Cys Ser Cys Phe Cys Asn Leu
              20                  25                  30        
 Leu Gly Leu Gly Cys Pro Ser Tyr Arg Glu Pro Pro Ser His Pro Ile
          35                  40                  45            
 Glu Gly Glu Leu Glu His Gly Met Pro Ser Tyr Cys Ser Cys Leu Pro
      50                  55                  60                
 Ala Ser Asp Gly His Arg Arg Arg Gly Leu Leu Leu Lys Glu Ser Gly
  65                  70                  75                  80
 Leu Gly Trp Arg Ala Arg Gly Gln Arg Thr Arg Leu Gly Ala
                  85                  90                



      <210> 704
      <211> 306
      <212> PRT
      <213> Homo sapiens


      <400> 704
 Met Ser Glu Val Thr Arg Ser Leu Leu Gln Arg Trp Gly Ala Ser Phe
   1               5                  10                  15    
 Arg Arg Gly Ala Asp Phe Asp Ser Trp Gly Gln Leu Val Glu Ala Ile
              20                  25                  30        
 Asp Glu Tyr Gln Ile Leu Ala Arg His Leu Gln Lys Glu Ala Gln Ala
          35                  40                  45            
 Gln His Asn Asn Ser Glu Phe Thr Glu Glu Gln Lys Lys Thr Ile Gly
      50                  55                  60                
 Lys Ile Ala Thr Cys Leu Glu Leu Arg Ser Ala Ala Leu Gln Ser Thr
  65                  70                  75                  80
 Gln Ser Gln Glu Glu Phe Lys Leu Glu Asp Leu Lys Lys Leu Glu Pro
                  85                  90                  95    
 Ile Leu Lys Asn Ile Leu Thr Tyr Asn Lys Glu Phe Pro Phe Asp Val
             100                 105                 110        
 Gln Pro Val Pro Leu Arg Arg Ile Leu Ala Pro Gly Glu Glu Glu Asn
         115                 120                 125            
 Leu Glu Phe Glu Glu Asp Glu Glu Glu Gly Gly Ala Gly Ala Gly Ser
     130                 135                 140                
 Pro Asp Ser Phe Pro Ala Arg Val Pro Gly Thr Leu Leu Pro Arg Leu
 145                 150                 155                 160
 Pro Ser Glu Pro Gly Met Thr Leu Leu Thr Ile Arg Ile Glu Lys Ile
                 165                 170                 175    
 Gly Leu Lys Asp Ala Gly Gln Cys Ile Asn Pro Tyr Ile Thr Val Ser
             180                 185                 190        
 Val Lys Asp Leu Asn Gly Ile Asp Leu Thr Pro Val Gln Asp Thr Pro
         195                 200                 205            
 Val Ala Ser Arg Lys Glu Asp Thr Tyr Val His Phe Asn Val Asp Ile
     210                 215                 220                
 Glu Leu Gln Lys His Val Glu Lys Leu Thr Lys Gly Ala Ala Ile Phe
 225                 230                 235                 240
 Phe Glu Phe Lys His Tyr Lys Pro Lys Lys Arg Phe Thr Ser Thr Lys
                 245                 250                 255    
 Cys Phe Ala Phe Met Glu Met Asp Glu Ile Lys Pro Gly Pro Ile Val
             260                 265                 270        
 Ile Glu Leu Tyr Lys Lys Pro Thr Asp Phe Lys Arg Lys Lys Leu Gln
         275                 280                 285            
 Leu Leu Thr Lys Lys Pro Leu Tyr Leu His Leu His Gln Thr Leu His
     290                 295                 300                
 Lys Glu
 305    



      <210> 705
      <211> 102
      <212> PRT
      <213> Homo sapiens


      <400> 705
 Met Asn His Leu Pro Pro Asn His Tyr Arg Ser His Val Phe Thr Cys
   1               5                  10                  15    
 His Val Asp Gln Tyr Leu Thr Val Glu Thr Ala Gly Gly Met Glu Lys
              20                  25                  30        
 Glu Ala Val Ser Val Thr Val Leu Leu Ser Ala Ala Pro Cys Leu Leu
          35                  40                  45            
 Ser Cys Phe Leu Gly Ser Ser Val Ser Gly Leu Ala Phe Trp Val Ser
      50                  55                  60                
 Gln Gln Lys Thr Lys Gly Pro Glu Arg Cys Lys Asn Thr His His Leu
  65                  70                  75                  80
 Ala Gly Asp Leu Lys Ile Leu Lys Leu Glu Ile Gly Thr Arg Lys Ser
                  85                  90                  95    
 Lys Glu Phe Lys Ala Ser
             100        



      <210> 706
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 706
 Met Glu Val Leu Gly His Phe Gly Gln Gly Ser Asn Gly Tyr Leu Glu
   1               5                  10                  15    
 Leu Ala Leu Pro Ser Ala Arg Gly Val Ser Val Cys Leu Arg Lys Trp
              20                  25                  30        
 Gln Ser Ala Ile Gln Asp Phe Arg Ser Asn Ala Thr Ala Leu Cys His
          35                  40                  45            
 Ile Arg Asn Gln Ala Trp Pro Gln Pro Glu Gly Thr Cys Ser Leu Met
      50                  55                  60                
 Gly Lys His Thr Lys Asn Lys Arg Ala Ser Arg Thr Cys Gly Ala Cys
  65                  70                  75                  80
 Gly Pro Glu Thr Ala Gly Asn Gly Ser Gln Ala Arg Val Ala Gly Arg
                  85                  90                  95    
 Thr His Val Ala Gly Ser Val Gly Gly Ser Tyr Arg Gly Lys Arg Pro
             100                 105                 110        
 Ser Gln Gln Leu Gly Glu Ala Ala Thr Leu Leu Val Asp Gly
         115                 120                 125    



      <210> 707
      <211> 982
      <212> PRT
      <213> Homo sapiens


      <400> 707
 Met Ser Ser Lys Met Val Ile Ser Glu Pro Gly Leu Asn Trp Asp Ile
   1               5                  10                  15    
 Ser Pro Lys Asn Gly Leu Lys Thr Phe Phe Ser Arg Glu Asn Tyr Lys
              20                  25                  30        
 Asp His Ser Met Ala Pro Ser Leu Lys Glu Leu Arg Val Leu Ser Asn
          35                  40                  45            
 Arg Arg Ile Gly Glu Asn Leu Asn Ala Ser Ala Ser Ser Val Glu Asn
      50                  55                  60                
 Glu Pro Ala Val Ser Ser Ala Thr Gln Ala Lys Glu Lys Val Lys Thr
  65                  70                  75                  80
 Thr Ile Gly Met Val Leu Leu Pro Lys Pro Arg Val Pro Tyr Pro Arg
                  85                  90                  95    
 Phe Ser Arg Phe Ser Gln Arg Glu Gln Arg Ser Tyr Val Asp Leu Leu
             100                 105                 110        
 Val Lys Tyr Ala Lys Ile Pro Ala Asn Ser Lys Ala Val Gly Ile Asn
         115                 120                 125            
 Lys Asn Asp Tyr Leu Gln Tyr Leu Asp Met Lys Lys His Val Asn Glu
     130                 135                 140                
 Glu Val Thr Glu Phe Leu Lys Phe Leu Gln Asn Ser Ala Lys Lys Cys
 145                 150                 155                 160
 Ala Gln Asp Tyr Asn Met Leu Ser Asp Asp Ala Arg Leu Phe Thr Glu
                 165                 170                 175    
 Lys Ile Leu Arg Ala Cys Ile Glu Gln Val Lys Lys Tyr Ser Glu Phe
             180                 185                 190        
 Tyr Thr Leu His Glu Val Thr Ser Leu Met Gly Phe Phe Pro Phe Arg
         195                 200                 205            
 Val Glu Met Gly Leu Lys Leu Glu Lys Thr Leu Leu Ala Leu Gly Ser
     210                 215                 220                
 Val Lys Tyr Val Lys Thr Val Phe Pro Ser Met Pro Ile Lys Leu Gln
 225                 230                 235                 240
 Leu Ser Lys Asp Asp Ile Ala Thr Ile Glu Thr Ser Glu Gln Thr Ala
                 245                 250                 255    
 Glu Ala Met His Tyr Asp Ile Ser Lys Asp Pro Asn Ala Glu Lys Leu
             260                 265                 270        
 Val Ser Arg Tyr His Pro Gln Ile Ala Leu Thr Ser Gln Ser Leu Phe
         275                 280                 285            
 Thr Leu Leu Asn Asn His Gly Pro Thr Tyr Lys Glu Gln Trp Glu Ile
     290                 295                 300                
 Pro Val Cys Ile Gln Val Ile Pro Val Ala Gly Ser Lys Pro Val Lys
 305                 310                 315                 320
 Val Ile Tyr Ile Asn Ser Pro Leu Pro Gln Lys Lys Met Thr Met Arg
                 325                 330                 335    
 Glu Arg Asn Gln Ile Phe His Glu Val Pro Leu Lys Phe Met Met Ser
             340                 345                 350        
 Lys Asn Thr Ser Val Pro Val Ser Ala Val Phe Met Asp Lys Pro Glu
         355                 360                 365            
 Glu Phe Ile Ser Glu Met Asp Met Ser Cys Glu Val Asn Glu Cys Arg
     370                 375                 380                
 Lys Ile Glu Ser Leu Glu Asn Leu Tyr Leu Asp Phe Asp Asp Asp Val
 385                 390                 395                 400
 Thr Glu Leu Glu Thr Phe Gly Val Thr Thr Thr Lys Val Ser Lys Ser
                 405                 410                 415    
 Pro Ser Pro Ala Ser Thr Ser Thr Val Pro Asn Met Thr Asp Ala Pro
             420                 425                 430        
 Thr Ala Pro Lys Ala Gly Thr Thr Thr Val Ala Pro Ser Ala Pro Asp
         435                 440                 445            
 Ile Ser Ala Asn Ser Arg Ser Leu Ser Gln Ile Leu Met Glu Gln Leu
     450                 455                 460                
 Gln Lys Glu Lys Gln Leu Val Thr Gly Met Asp Gly Gly Pro Glu Glu
 465                 470                 475                 480
 Cys Lys Asn Lys Asp Asp Gln Gly Phe Glu Ser Cys Glu Lys Val Ser
                 485                 490                 495    
 Asn Ser Asp Lys Pro Leu Ile Gln Asp Ser Asp Leu Lys Thr Ser Asp
             500                 505                 510        
 Ala Leu Gln Leu Glu Asn Ser Gln Glu Ile Glu Thr Ser Asn Lys Asn
         515                 520                 525            
 Asp Met Thr Ile Asp Ile Leu His Ala Asp Gly Glu Arg Pro Asn Val
     530                 535                 540                
 Leu Glu Asn Leu Asp Asn Ser Lys Glu Lys Thr Val Gly Ser Glu Ala
 545                 550                 555                 560
 Ala Lys Thr Glu Asp Thr Val Leu Cys Ser Ser Asp Thr Asp Glu Glu
                 565                 570                 575    
 Cys Leu Ile Ile Asp Thr Glu Cys Lys Asn Asn Ser Asp Gly Lys Thr
             580                 585                 590        
 Ala Val Val Gly Ser Asn Leu Ser Ser Arg Pro Ala Ser Pro Asn Ser
         595                 600                 605            
 Ser Ser Gly Gln Ala Ser Val Gly Asn Gln Thr Asn Thr Ala Cys Ser
     610                 615                 620                
 Pro Glu Glu Ser Cys Val Leu Lys Lys Pro Ile Lys Arg Val Tyr Lys
 625                 630                 635                 640
 Lys Phe Asp Pro Val Gly Glu Ile Leu Lys Met Gln Asp Glu Leu Leu
                 645                 650                 655    
 Lys Pro Ile Ser Arg Lys Val Pro Glu Leu Pro Leu Met Asn Leu Glu
             660                 665                 670        
 Asn Ser Lys Gln Pro Ser Val Ser Glu Gln Leu Ser Gly Pro Ser Asp
         675                 680                 685            
 Ser Ser Ser Trp Pro Lys Ser Gly Trp Pro Ser Ala Phe Gln Lys Pro
     690                 695                 700                
 Lys Gly Arg Leu Pro Tyr Glu Leu Gln Asp Tyr Val Glu Asp Thr Ser
 705                 710                 715                 720
 Glu Tyr Leu Ala Pro Gln Glu Gly Asn Phe Val Tyr Lys Leu Phe Ser
                 725                 730                 735    
 Leu Gln Asp Leu Leu Leu Leu Val Arg Cys Ser Val Gln Arg Ile Glu
             740                 745                 750        
 Thr Arg Pro Arg Ser Lys Lys Arg Lys Lys Ile Arg Arg Gln Phe Pro
         755                 760                 765            
 Val Tyr Val Leu Pro Lys Val Glu Tyr Gln Ala Cys Tyr Gly Val Glu
     770                 775                 780                
 Ala Leu Thr Glu Ser Glu Leu Cys Arg Leu Trp Thr Glu Ser Leu Leu
 785                 790                 795                 800
 His Ser Asn Ser Ser Phe Tyr Val Gly His Ile Asp Ala Phe Thr Ser
                 805                 810                 815    
 Lys Leu Phe Leu Leu Glu Glu Ile Thr Ser Glu Glu Leu Lys Glu Lys
             820                 825                 830        
 Leu Ser Ala Leu Lys Ile Ser Asn Leu Phe Asn Ile Leu Gln His Ile
         835                 840                 845            
 Leu Lys Lys Leu Ser Ser Leu Gln Glu Gly Ser Tyr Leu Leu Ser His
     850                 855                 860                
 Ala Ala Glu Asp Ser Ser Leu Leu Ile Tyr Lys Ala Ser Asp Gly Lys
 865                 870                 875                 880
 Val Thr Arg Thr Ala Tyr Asn Leu Tyr Lys Thr His Cys Gly Leu Pro
                 885                 890                 895    
 Gly Val Pro Ser Ser Leu Ser Val Pro Trp Val Pro Leu Asp Pro Ser
             900                 905                 910        
 Leu Leu Leu Pro Tyr His Ile His His Gly Arg Ile Pro Cys Thr Phe
         915                 920                 925            
 Pro Pro Lys Ser Leu Asp Thr Thr Thr Gln Gln Lys Ile Gly Gly Thr
     930                 935                 940                
 Arg Met Pro Thr Arg Ser His Arg Asn Pro Val Ser Met Glu Thr Lys
 945                 950                 955                 960
 Ser Ser Cys Leu Pro Ala Gln Gln Val Glu Thr Glu Gly Val Ala Pro
                 965                 970                 975    
 His Lys Arg Lys Ile Thr
             980        



      <210> 708
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 708
 Met Ser Val Pro Gly Pro Tyr Gln Ala Ala Thr Gly Pro Ser Ser Ala
   1               5                  10                  15    
 Pro Ser Ala Pro Pro Ser Tyr Glu Glu Thr Val Ala Val Asn Ser Tyr
              20                  25                  30        
 Tyr Pro Thr Pro Pro Ala Pro Met Pro Gly Pro Thr Thr Gly Leu Val
          35                  40                  45            
 Thr Gly Pro Asp Gly Lys Gly Met Asn Pro Pro Ser Tyr Tyr Thr Gln
      50                  55                  60                
 Pro Ala Pro Ile Pro Asn Asn Asn Pro Ile Thr Val Gln Thr Val Tyr
  65                  70                  75                  80
 Val Gln His Pro Ile Thr Phe Leu Asp Arg Pro Val Gln Met Cys Cys
                  85                  90                  95    
 Pro Ser Cys Asn Lys Met Ile Val Ser Gln Leu Ser Tyr Asn Ala Gly
             100                 105                 110        
 Ala Leu Thr Trp Leu Ser Cys Gly Ser Leu Cys Leu Leu Gly Cys Ile
         115                 120                 125            
 Ala Gly Cys Cys Phe Ile Pro Phe Cys Val Asp Ala Leu Gln Asp Val
     130                 135                 140                
 Asp His Tyr Cys Pro Asn Cys Arg Ala Leu Leu Gly Thr Tyr Lys Arg
 145                 150                 155                 160
 Leu
    



      <210> 709
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 709
 Met Pro Pro Lys Asp Asp Thr Ile Lys Asn Asp Ala Glu Gln Ser Val
   1               5                  10                  15    
 Ile Lys Asp Leu Asp Pro Val Asn Lys Ser Gly Gly Ile Ala Gln Lys
              20                  25                  30        
 Lys Ile Arg Ala Ile Gly Arg Ala Arg Asp Met Leu Asn Tyr Ser Asp
          35                  40                  45            
 Leu Leu Asp Glu Ala Thr Tyr Asp Lys Leu Cys Lys Glu Val Pro Asn
      50                  55                  60                
 Tyr Lys Leu Ile Thr Pro Ala Val Gly Ser Asp Arg Leu Asn Ile Glu
  65                  70                  75                  80
 Gly Ser Leu Ala Arg Ala Ala Leu Gln Glu Leu Leu Arg His Gly Leu
                  85                  90                  95    
 Ile Thr Leu Val Ser Lys His Arg Ala Pro Val Ile Tyr Pro Arg Asn
             100                 105                 110        
 His Lys Gly Gly Thr Ala Pro Thr Ala Gly Ala Asp Ala
         115                 120                 125



      <210> 710
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 710
 Met Lys Met Phe Glu Ser Ala Asp Ser Thr Ala Thr Arg Ser Gly Gln
   1               5                  10                  15    
 Asp Leu Trp Ala Glu Ile Cys Ser Cys Leu Pro Asn Pro Glu Gln Glu
              20                  25                  30        
 Asp Gly Ala Asn Asn Ala Phe Ser Asp Ser Phe Val Asp Ser Cys Pro
          35                  40                  45            
 Glu Gly Glu Gly Gln Arg Glu Val Ala Asp Phe Ala Val Gln Pro Ala
      50                  55                  60                
 Val Lys Pro Trp Ala Pro Leu Gln Asp Ser Glu Val Tyr Leu Ala Ser
  65                  70                  75                  80
 Leu Glu Lys Lys Leu Arg Arg Ile Lys Gly Leu Asn Gln Glu Val Thr
                  85                  90                  95    
 Ser Lys Asp Met Leu Arg Thr Leu Ala Gln Ala Lys Lys Glu Cys Trp
             100                 105                 110        
 Asp Arg Phe Leu Gln Glu Lys Leu Ala Ser Glu Phe Phe Val Asp Gly
         115                 120                 125            
 Leu Asp Ser Asp Glu Arg
     130                



      <210> 711
      <211> 696
      <212> PRT
      <213> Homo sapiens


      <400> 711
 Met Glu Leu Gly Ser Cys Phe Lys Thr Tyr Glu Asp Phe Lys Glu Cys
   1               5                  10                  15    
 Phe Ser Ala Tyr Lys Arg Glu Asn Arg Cys Ser Phe Ile Leu Arg Asp
              20                  25                  30        
 Cys Val Ser Val Arg Phe His Asn Leu Asn His Gly Thr Ser Ile Arg
          35                  40                  45            
 Glu Asp Ile Leu Tyr Val Gln Val Lys Phe Val Cys Ile Arg Thr Gln
      50                  55                  60                
 Ser Asn Arg Lys Arg Thr Arg Glu Ala Asp Met Cys Pro Ala Tyr Leu
  65                  70                  75                  80
 Leu Leu Arg Tyr Asn Glu Arg Leu Asp Arg Leu Phe Ile Ser Glu Leu
                  85                  90                  95    
 Asn Thr Gln His Ile His Gly Asp Ser Lys Val Ala Ser Pro Gly Gly
             100                 105                 110        
 Asp Thr Thr Gly Lys Ser Gln Lys Thr Met Cys Leu Gln Arg Leu Gln
         115                 120                 125            
 Pro Val Gln Pro Thr Thr Lys Lys Asp Leu Asp Thr Ala Glu Lys Ser
     130                 135                 140                
 Leu Val Glu Pro Ser Phe Cys Leu Asp Lys Val Gln Val Ser Ser Lys
 145                 150                 155                 160
 Pro Glu Gln Glu Gly Ile Thr Pro Ser Asp Leu Ala Lys Ile Ala Lys
                 165                 170                 175    
 Val Met Lys Asn Phe Leu Lys Val Asp Glu Gly Ser Met Ala Ser Phe
             180                 185                 190        
 Ser Val Gly Asp Ser Gln His Leu Asp Arg Leu Ser Phe Gln Ser Ser
         195                 200                 205            
 Lys Met Thr Asp Leu Phe Ile Arg Phe Pro Glu Asn Leu Leu Leu His
     210                 215                 220                
 Arg Val Glu Asn Thr Gln Gly His Ile Leu Tyr Ala Phe Leu Val Glu
 225                 230                 235                 240
 Asn Lys Glu Arg Glu Ser Arg Val Val His Phe Ala Val Leu Lys Ala
                 245                 250                 255    
 Glu Thr Val Thr Ser Val Ala Lys Met Leu Ser Ile Phe Thr Glu Phe
             260                 265                 270        
 Asn Ser Asp Trp Pro Lys Val Lys Val Val Phe Val Asp Pro Ser Phe
         275                 280                 285            
 His Tyr Arg Ala Ile Leu Gln Glu Ile Phe Pro Ala Ala Arg Ile Leu
     290                 295                 300                
 Leu Ser Ile Tyr His Thr Thr Arg Leu Leu Glu Lys Lys Leu His Arg
 305                 310                 315                 320
 Ser Ser Ala Asn Pro Ser Phe Lys Arg Leu Met Lys Glu Ala Leu Arg
                 325                 330                 335    
 Glu Ala Val Phe Val Thr Ser Glu Ala Ser Leu Lys Asn Leu Cys Gln
             340                 345                 350        
 Met Ser Gln Ala Val Leu Asp Glu Asp Leu Phe Asn Phe Leu Gln Ala
         355                 360                 365            
 His Trp Phe Thr Cys Glu Leu Leu Trp Tyr Met His Val Arg Lys Gly
     370                 375                 380                
 Leu Leu Ala Cys Asn Thr Tyr Met Asp Ser Leu Asp Ile Val Thr Ser
 385                 390                 395                 400
 Lys Val Ser Ser Leu Phe Arg Glu Gln Gln Ser Leu Leu Asp Cys Ile
                 405                 410                 415    
 Leu Cys Phe Val Asp Tyr Ile Asp Phe Phe Asn Thr Lys Gly Leu Lys
             420                 425                 430        
 Asn Leu Pro Thr Pro Pro Pro Lys Leu Lys Arg Ala Arg Pro Ala Ser
         435                 440                 445            
 Met Pro Leu Lys Ser Lys Lys Ala Phe Gly Ile Cys Gly Glu Ser Leu
     450                 455                 460                
 Thr Ser Leu Pro Ala Glu Glu Thr Lys Pro Asp Ala Gln Gln Val Gln
 465                 470                 475                 480
 Val Gln Gln Gln Ser Gln Val Pro Pro Ser Gln Val Gly Met Leu Asp
                 485                 490                 495    
 Thr Leu His Gln Ser Gly Ser Glu Leu Ala Tyr Lys Leu Cys His Asn
             500                 505                 510        
 Glu Trp Glu Val Val Gln Asn Ser Thr His Leu Val Asp Met Ala Gly
         515                 520                 525            
 Ser Ser Val Asp Val Gln Leu Leu Glu Asp Ser His Gln Val Ser Lys
     530                 535                 540                
 Asp Gly Cys Ser Cys Ser Cys Ser Phe Gln Gln Trp Tyr His Leu Pro
 545                 550                 555                 560
 Cys Arg His Ile Leu Ala Leu Leu His Thr Ser Gln Gln Pro Val Gly
                 565                 570                 575    
 Glu Ala Met Val Cys Arg Arg Trp Gln Lys Lys Tyr Gln Tyr Leu Leu
             580                 585                 590        
 Gly Pro Asn Gly Glu Leu Gln Asp Arg Gly Met Val Pro Asn Thr Gly
         595                 600                 605            
 Gln Pro Glu Lys Gln Gly Arg Asn Asp Met Ile Gln Asp Leu Ser Arg
     610                 615                 620                
 Glu Leu Ala Asn Leu Leu Met Gln Thr Glu Gly Pro Glu Leu Glu Glu
 625                 630                 635                 640
 Arg Tyr Ser Thr Leu Arg Lys Ile Val Asp Ile Trp Ala Gly Pro Ser
                 645                 650                 655    
 Gln Pro Ser Glu Leu Phe Gln Gln Pro Gly Asp Phe Lys Asp Val Gly
             660                 665                 670        
 Arg Leu Pro Phe Leu Trp Gly Lys Gln Glu Glu Gly Glu Gly Phe Pro
         675                 680                 685            
 Pro Ala Thr Ala Val Met His Tyr
     690                 695    



      <210> 712
      <211> 66
      <212> PRT
      <213> Homo sapiens


      <400> 712
 Met Val Phe Glu Ser Val Gly Ala Arg Ala His Phe Trp Leu Ser Gln
   1               5                  10                  15    
 Gln Leu Gly Trp His Leu Leu Pro Ser Ala Arg Asn Ser Asn Ile Met
              20                  25                  30        
 Asn Ala Arg Asp Ser Val Leu Ser Lys Val Phe His Pro Lys Arg Gly
          35                  40                  45            
 Lys Glu Gly Gly Ser Ala Val Ile Gln His Leu Gly Ala His Gly Ala
      50                  55                  60                
 Val Thr
  65    



      <210> 713
      <211> 95
      <212> PRT
      <213> Homo sapiens


      <400> 713
 Met Thr Trp Gly Leu Gln His Pro Ser Ser Lys Pro Phe Pro Lys Lys
   1               5                  10                  15    
 Val Lys Arg Ser Gln Asp Asp Trp His Leu Leu Leu Leu Leu Leu Phe
              20                  25                  30        
 Phe Leu Phe Pro Cys Pro Ala Pro Ser Cys Ala Cys Val Ser Asp Asn
          35                  40                  45            
 Thr Gly Ala Ser Thr Gly Val Glu Asn Pro Ala Ala Gln Leu Ser Ser
      50                  55                  60                
 Ala His Arg Ser Leu Gly Asn Gly Leu Ser Leu Cys Asn Lys Lys Ile
  65                  70                  75                  80
 Phe Phe Phe Phe Leu Asn Leu His Tyr Ile Phe Phe Asp Cys Leu
                  85                  90                  95



      <210> 714
      <211> 220
      <212> PRT
      <213> Homo sapiens


      <400> 714
 Met Arg Gln Lys His Tyr Leu Glu Ala Ala Ala Arg Gly Leu His Asp
   1               5                  10                  15    
 Ser Cys Pro Gly Gln Ala Arg Tyr Leu Leu Trp Ala Tyr Thr Ser Ser
              20                  25                  30        
 His Asp Asp Lys Ser Thr Phe Glu Glu Thr Cys Pro Tyr Cys Phe Gln
          35                  40                  45            
 Leu Leu Val Leu Asp Asn Ser Arg Val Arg Leu Lys Pro Lys Ala Arg
      50                  55                  60                
 Leu Thr Pro Lys Ile Gln Lys Leu Leu Asn Arg Glu Ala Arg Asn Tyr
  65                  70                  75                  80
 Thr Leu Ser Phe Lys Glu Ala Lys Met Val Lys Lys Phe Lys Asp Ser
                  85                  90                  95    
 Lys Ser Val Leu Leu Ile Thr Cys Lys Thr Cys Asn Arg Thr Val Lys
             100                 105                 110        
 His His Gly Lys Ser Arg Ser Phe Val Ser Thr Leu Lys Ser Asn Pro
         115                 120                 125            
 Ala Thr Pro Thr Ser Lys Leu Ser Leu Lys Thr Pro Glu Arg Arg Thr
     130                 135                 140                
 Ala Asn Pro Asn His Asp Met Ser Gly Ser Lys Gly Lys Ser Pro Ala
 145                 150                 155                 160
 Ser Val Phe Arg Thr Pro Thr Ser Gly Gln Ser Val Ser Thr Cys Ser
                 165                 170                 175    
 Ser Lys Asn Thr Ser Lys Thr Lys Lys His Phe Ser Gln Leu Lys Met
             180                 185                 190        
 Leu Leu Ser Gln Asn Glu Ser Gln Lys Ile Pro Lys Val Asp Phe Arg
         195                 200                 205            
 Asn Phe Leu Ser Ser Leu Lys Gly Gly Leu Leu Lys
     210                 215                 220



      <210> 715
      <211> 177
      <212> PRT
      <213> Homo sapiens


      <400> 715
 Met Ala Gly Pro Val Lys Asp Arg Glu Ala Phe Gln Arg Leu Asn Phe
   1               5                  10                  15    
 Leu Tyr Gln Val Ser Leu Arg Gln Gly Pro His Gly Asp Gly Ala Arg
              20                  25                  30        
 Arg Pro Arg Val Thr Ala Pro Leu Pro Gln Ala Ala His Cys Val Leu
          35                  40                  45            
 Ala Gln Asp Pro Glu Asn Gln Ala Leu Ala Arg Phe Tyr Cys Tyr Thr
      50                  55                  60                
 Glu Arg Thr Ile Ala Lys Arg Leu Val Leu Arg Arg Asp Pro Ser Val
  65                  70                  75                  80
 Lys Arg Thr Leu Cys Arg Gly Cys Ser Ser Leu Leu Val Pro Gly Leu
                  85                  90                  95    
 Thr Cys Thr Gln Arg Gln Arg Arg Cys Arg Gly Gln Arg Trp Thr Val
             100                 105                 110        
 Gln Thr Cys Leu Thr Cys Gln Arg Ser Gln Arg Phe Leu Asn Asp Pro
         115                 120                 125            
 Gly His Leu Leu Trp Gly Asp Arg Pro Glu Ala Gln Leu Gly Ser Gln
     130                 135                 140                
 Ala Asp Ser Lys Pro Leu Gln Pro Leu Pro Asn Thr Ala His Ser Ile
 145                 150                 155                 160
 Ser Asp Arg Leu Pro Glu Glu Lys Met Gln Thr Lys Gly Ser Ser Asn
                 165                 170                 175    
 Gln
    



      <210> 716
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 716
 Met Ala Glu Arg Pro Gly Pro Pro Gly Gly Ala Val Ser Ala Thr Ala
   1               5                  10                  15    
 Tyr Pro Asp Thr Pro Ala Glu Phe Pro Pro His Leu Gln Ala Gly Ala
              20                  25                  30        
 Met Arg Arg Arg Phe Trp Gly Val Phe Asn Cys Leu Cys Ala Gly Ala
          35                  40                  45            
 Phe Gly Ala Leu Ala Ala Ala Ser Ala Lys Leu Ala Phe Gly Ser Glu
      50                  55                  60                
 Val Ser Met Gly Leu Cys Val Leu Gly Ile Ile Val Met Ala Ser Thr
  65                  70                  75                  80
 Asn Ser Leu Met Trp Thr Phe Phe Ser Arg Gly Leu Ser Phe Ser Met
                  85                  90                  95    
 Ser Ser Ala Ile Ala Ser Val Thr Val Thr Phe Ser Asn Ile Leu Ser
             100                 105                 110        
 Ser Ala Phe Leu Gly Tyr Val Leu Tyr Gly Glu Cys Gln Glu Val Leu
         115                 120                 125            
 Trp Trp Gly Gly Val Phe Leu Ile Leu Cys Gly Leu Thr Leu Ile His
     130                 135                 140                
 Arg Lys Leu Pro Pro Thr Trp Lys Pro Leu Pro His Lys Gln Gln
 145                 150                 155                



      <210> 717
      <211> 375
      <212> PRT
      <213> Homo sapiens


      <400> 717
 Met Leu Gly Ala Glu Ala Thr Phe Ile Leu Phe Gln Pro Pro Ala Asn
   1               5                  10                  15    
 Thr Phe Thr Ser Ala Phe Ser Gln Thr Arg Ala Arg Arg Gly Gly Ser
              20                  25                  30        
 Gly Arg Gly Gly Gly Gln Glu Ser Ala Glu Glu Thr Ser Glu Phe Gly
          35                  40                  45            
 Asp Arg His Ala Pro Glu Ala Ala Ala Ala Thr Arg Gly Ser Ala Arg
      50                  55                  60                
 Ala Pro Glu Pro Lys His Ala Ser Ser Cys Gly Thr Arg Gly Gln Cys
  65                  70                  75                  80
 Ala Cys Ala Arg Arg Glu Val Glu Ala Gln Val Arg Ala Lys Gly Asp
                  85                  90                  95    
 Thr Val Ala Glu Arg Ala Arg Arg Gly Gly Arg Trp Leu Thr Arg Ser
             100                 105                 110        
 Gly Met Glu His Leu Glu Arg Cys Glu Trp Leu Leu Arg Gly Thr Leu
         115                 120                 125            
 Val Arg Ala Ala Val Arg Arg Tyr Leu Pro Trp Ala Leu Val Ala Ser
     130                 135                 140                
 Met Leu Ala Gly Ser Leu Leu Lys Glu Leu Ser Pro Leu Pro Glu Ser
 145                 150                 155                 160
 Tyr Leu Ser Asn Lys Arg Asn Val Leu Asn Val Tyr Phe Val Lys Val
                 165                 170                 175    
 Ala Trp Ala Trp Thr Phe Cys Leu Leu Leu Pro Phe Ile Ala Leu Thr
             180                 185                 190        
 Asn Tyr His Leu Thr Gly Lys Ala Gly Leu Val Leu Arg Arg Leu Ser
         195                 200                 205            
 Thr Leu Leu Val Gly Thr Ala Ile Trp Tyr Ile Cys Thr Ser Ile Phe
     210                 215                 220                
 Ser Asn Ile Glu His Tyr Thr Gly Ser Cys Tyr Gln Ser Pro Ala Leu
 225                 230                 235                 240
 Glu Gly Val Arg Lys Glu His Gln Ser Lys Gln Gln Cys His Gln Glu
                 245                 250                 255    
 Gly Gly Phe Trp His Gly Phe Asp Ile Ser Gly His Ser Phe Leu Leu
             260                 265                 270        
 Thr Phe Cys Ala Leu Met Ile Val Glu Glu Met Ser Val Leu His Glu
         275                 280                 285            
 Val Lys Thr Asp Arg Ser His Cys Leu His Thr Ala Ile Thr Thr Leu
     290                 295                 300                
 Val Val Ala Leu Gly Ile Leu Thr Phe Ile Trp Val Leu Met Phe Leu
 305                 310                 315                 320
 Cys Thr Ala Val Tyr Phe His Asn Leu Ser Gln Lys Val Phe Gly Thr
                 325                 330                 335    
 Leu Phe Gly Leu Leu Ser Trp Tyr Gly Thr Tyr Gly Phe Trp Tyr Pro
             340                 345                 350        
 Lys Ala Phe Ser Pro Gly Leu Pro Pro Gln Ser Cys Ser Leu Asn Leu
         355                 360                 365            
 Lys Gln Asp Ser Tyr Lys Lys
     370                 375



      <210> 718
      <211> 367
      <212> PRT
      <213> Homo sapiens


      <400> 718
 Met Val Cys Asp Asn Leu Asn Leu Pro Phe Arg Asp Glu Gly Phe Asp
   1               5                  10                  15    
 Ala Ile Ile Ser Ile Gly Val Ile His His Phe Ser Thr Lys Gln Arg
              20                  25                  30        
 Arg Ile Arg Ala Ile Lys Glu Met Ala Arg Val Leu Val Pro Gly Gly
          35                  40                  45            
 Gln Leu Met Ile Tyr Val Trp Ala Met Glu Gln Lys Asn Arg Arg Phe
      50                  55                  60                
 Glu Lys Gln Asp Val Leu Val Pro Trp Asn Arg Ala Leu Cys Ser Gln
  65                  70                  75                  80
 Leu Phe Ser Glu Ser Ser Gln Ser Gly Arg Lys Arg Gln Cys Gly Tyr
                  85                  90                  95    
 Pro Glu Arg Gly His Pro Tyr His Pro Pro Cys Ser Glu Cys Ser Cys
             100                 105                 110        
 Ser Val Cys Phe Lys Glu Gln Cys Gly Ser Lys Arg Ser His Ser Val
         115                 120                 125            
 Gly Tyr Glu Thr Ala Met Ala Arg Thr Cys Phe Ala Asn Ile Ser Lys
     130                 135                 140                
 Glu Gly Glu Glu Glu Tyr Gly Phe Tyr Ser Thr Leu Gly Lys Ser Phe
 145                 150                 155                 160
 Arg Ser Trp Phe Phe Ser Arg Ser Leu Asp Glu Ser Thr Leu Arg Lys
                 165                 170                 175    
 Gln Ile Glu Arg Val Arg Pro Leu Lys Asn Thr Glu Val Trp Ala Ser
             180                 185                 190        
 Ser Thr Val Thr Val Gln Pro Ser Arg His Ser Ser Leu Asp Phe Asp
         195                 200                 205            
 His Gln Glu Pro Phe Ser Thr Lys Glu Gln Ser Leu Asp Glu Glu Val
     210                 215                 220                
 Phe Val Glu Ser Ser Ser Gly Lys His Leu Glu Trp Leu Arg Ala Pro
 225                 230                 235                 240
 Gly Thr Leu Lys His Leu Asn Gly Asp His Gln Gly Glu Met Arg Arg
                 245                 250                 255    
 Asn Gly Gly Gly Asn Phe Leu Asp Ser Thr Asn Thr Gly Val Asn Cys
             260                 265                 270        
 Val Asp Ala Gly Asn Ile Glu Asp Asp Asn Pro Ser Ala Ser Lys Ile
         275                 280                 285            
 Leu Arg Arg Ile Ser Ala Val Asp Ser Thr Asp Phe Asn Pro Asp Asp
     290                 295                 300                
 Thr Met Ser Val Glu Asp Pro Gln Thr Asp Val Leu Asp Ser Thr Ala
 305                 310                 315                 320
 Phe Met Arg Tyr Tyr His Val Phe Arg Glu Gly Glu Leu Cys Ser Leu
                 325                 330                 335    
 Leu Lys Glu Asn Val Ser Glu Leu Arg Ile Leu Ser Ser Gly Asn Asp
             340                 345                 350        
 His Gly Asn Trp Cys Ile Ile Ala Glu Lys Lys Arg Gly Cys Asp
         355                 360                 365        



      <210> 719
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 719
 Met Glu Val Gly Leu Pro Ala Ile Thr Leu Phe Leu Thr Ser Ala Ser
   1               5                  10                  15    
 Ser Pro Val Val Ala Thr Thr Met Asp Gln Glu Pro Val Gly Gly Val
              20                  25                  30        
 Glu Arg Gly Glu Ala Val Ala Ala Ser Gly Ala Ala Ala Ala Ala Ala
          35                  40                  45            
 Phe Gly Glu Ser Ala Gly Gln Met Ser Asn Glu Arg Gly Phe Glu Asn
      50                  55                  60                
 Val Glu Leu Gly Val Ile Gly Lys Lys Lys Lys Val Pro Arg Arg Val
  65                  70                  75                  80
 Ile His Phe Val Ser Gly Glu Thr Met Glu Glu Tyr Ser Thr Asp Glu
                  85                  90                  95    
 Asp Glu Val Asp Gly Leu Glu Lys Lys Asp Val Leu Pro Thr Val Asp
             100                 105                 110        
 Pro Thr Lys Leu Thr Trp Gly Pro Tyr Leu Trp Phe Tyr Met Leu Arg
         115                 120                 125            
 Ala Ala Thr Ser Thr Leu Ser Val Cys Asp Phe Leu Gly Glu Lys Ile
     130                 135                 140                
 Ala Ser Val Leu Gly Ile Ser Thr Pro Lys Tyr Gln Tyr Ala Ile Asp
 145                 150                 155                 160
 Glu Tyr Tyr Arg Met Lys Lys Glu Glu Glu Glu Glu Glu Glu Glu Asn
                 165                 170                 175    
 Arg Met Ser Glu Glu Ala Glu Lys Gln Tyr Gln Gln Asn Lys Leu Gln
             180                 185                 190        
 Thr Asp Ser Ile Val Gln Thr Asp Gln Pro Glu Thr Val Ile Ser Ser
         195                 200                 205            
 Ser Phe Val Asn Val Asn Phe Glu Met Glu Gly Asp Ser Glu Val Ile
     210                 215                 220                
 Met Glu Ser Lys Gln Asn Pro Val Ser Val Pro Pro
 225                 230                 235    



      <210> 720
      <211> 29
      <212> PRT
      <213> Homo sapiens


      <400> 720
 Met Ser Thr His Met Ala Asn Gln Ile Asn Gln Tyr Lys Ser Thr Ser
   1               5                  10                  15    
 Ser Leu Ile Pro Pro Ile Arg Glu Val Glu Asp Glu Cys
              20                  25                



      <210> 721
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 721
 Met Ile Glu Glu Leu His Met Cys Ala Lys Val Phe Val Ser Met Trp
   1               5                  10                  15    
 Lys Thr Gln Glu Ala Asn Ser Thr Val Phe Leu Trp Ser Gly Cys Lys
              20                  25                  30        
 Gly Arg Asp Leu Thr Leu Tyr Ile Leu Met Ala Ala Phe Glu Tyr Leu
          35                  40                  45            
 Leu Thr Pro Ser Ser Leu Asn Trp Gly Cys Val Ser
      50                  55                  60



      <210> 722
      <211> 331
      <212> PRT
      <213> Homo sapiens


      <400> 722
 Met Leu Ser Pro Glu Arg Leu Ala Leu Pro Asp Tyr Glu Tyr Leu Ala
   1               5                  10                  15    
 Gln Arg His Val Leu Thr Tyr Met Glu Asp Ala Val Cys Gln Leu Leu
              20                  25                  30        
 Glu Asn Arg Glu Asp Ile Ser Gln Tyr Gly Ile Ala Arg Phe Phe Thr
          35                  40                  45            
 Glu Tyr Phe Asn Ser Val Cys Gln Gly Thr His Ile Leu Phe Arg Glu
      50                  55                  60                
 Phe Ser Phe Val Gln Ala Thr Pro His Asn Arg Val Ser Phe Leu Arg
  65                  70                  75                  80
 Ala Phe Trp Arg Cys Phe Arg Thr Val Gly Lys Asn Gly Asp Leu Leu
                  85                  90                  95    
 Thr Met Lys Glu Tyr His Cys Leu Leu Gln Leu Leu Cys Pro Asp Phe
             100                 105                 110        
 Pro Leu Glu Leu Thr Gln Lys Ala Ala Arg Ile Val Leu Met Asp Asp
         115                 120                 125            
 Ala Met Asp Cys Leu Met Ser Phe Ser Asp Phe Leu Phe Ala Phe Gln
     130                 135                 140                
 Ile Gln Phe Tyr Tyr Ser Glu Phe Leu Asp Ser Val Ala Ala Ile Tyr
 145                 150                 155                 160
 Glu Asp Leu Leu Ser Gly Lys Asn Pro Asn Thr Val Ile Val Pro Thr
                 165                 170                 175    
 Ser Ser Ser Gly Gln His Arg Gln Arg Pro Ala Leu Gly Gly Ala Gly
             180                 185                 190        
 Thr Leu Glu Gly Val Glu Ala Ser Leu Phe Tyr Gln Cys Leu Glu Asn
         195                 200                 205            
 Leu Cys Asp Arg His Lys Tyr Ser Cys Pro Pro Pro Ala Leu Val Lys
     210                 215                 220                
 Glu Ala Leu Ser Asn Val Gln Arg Leu Thr Phe Tyr Gly Phe Leu Met
 225                 230                 235                 240
 Ala Leu Ser Lys His Arg Gly Ile Asn Gln Ala Leu Gly Ala Leu Pro
                 245                 250                 255    
 Asp Lys Gly Asp Leu Met His Asp Pro Ala Met Asp Glu Glu Leu Glu
             260                 265                 270        
 Arg Leu Leu Ala Gln Val Pro Gly Leu Val Asn Ser Val Thr Ala Ser
         275                 280                 285            
 Pro Glu Ala Ser Cys Leu Pro Ser Arg Thr Pro Pro Arg Val Gly Ser
     290                 295                 300                
 Pro Trp Arg Pro Leu His His Ser Arg Lys Val Asp Gly Glu Ser Asp
 305                 310                 315                 320
 Gly Ser Thr Glu Glu Thr Asp Glu Ser Glu Thr
                 325                 330    



      <210> 723
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 723
 Met Val Trp Gln Glu Lys Glu Asp Met His Lys Gln Leu Val Glu Ala
   1               5                  10                  15    
 Ser Glu Thr Leu Lys Ser Gln Ala Lys Glu Leu Lys Asp Ala His Gln
              20                  25                  30        
 Gln Gln Lys Leu Ala Leu Gln Glu Phe Leu Glu Leu Asn Glu Leu Met
          35                  40                  45            
 Ala Glu Leu Tyr Ser Gln Lys Gln Lys Val Trp Asp Lys Glu Glu Glu
      50                  55                  60                
 Met Glu Val Ala Met Gln Lys Ala Asp Met Met Trp Gln Glu Ile
  65                  70                  75                



      <210> 724
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 724
 Met Pro Ser Leu Ser Lys Ile Leu Asn Ser Ser Leu Ala Lys Ser Ala
   1               5                  10                  15    
 Pro Leu Asn Pro Ala Ser Leu Leu Pro Val Ser Ser Ser Pro Pro Thr
              20                  25                  30        
 His Ser Cys Thr Asp Ile Leu Asp His Leu Gln Pro His Phe Pro Asn
          35                  40                  45            
 Ile Ser Ser Glu Pro Leu Thr Asn Pro Asp Asp Gln Leu Phe Ile Asp
      50                  55                  60                
 Gly Ser Ser Ser Gly Pro Thr Gly Pro Pro Lys Ile Val Gly Ile Gln
  65                  70                  75                  80
 Leu Lys Ser Pro Thr Pro Ser His Pro Val Phe Thr Gly Pro Tyr Gln
                  85                  90                  95    
 Ser Leu His Pro Leu Asp Asn Thr Arg Tyr Asn Ala Ala Pro Gly Ile
             100                 105                 110        
 Pro Met Ala Pro Lys Thr Val Val Pro Thr Val Gln Pro Ser Pro Thr
         115                 120                 125            
 Thr Val Ala Pro Ser Gln Gln Glu Ala Ala Lys Arg Gln Trp His Pro
     130                 135                 140                
 Ser Ser Ile Thr Tyr
 145                



      <210> 725
      <211> 49
      <212> PRT
      <213> Homo sapiens


      <400> 725
 Met Ala Ser Asp Ser Ile Phe Glu Ser Phe Pro Ser Tyr Pro Gln Cys
   1               5                  10                  15    
 Phe Met Arg Ala Leu Arg Asp Ser Ala Lys Arg His Ile Ala Leu Glu
              20                  25                  30        
 Glu Ser Ala Pro Gly Gln Ser Asn Lys Gln His Gln Ser Pro Ala Glu
          35                  40                  45            
 Ser
    



      <210> 726
      <211> 279
      <212> PRT
      <213> Homo sapiens


      <400> 726
 Met Gly Gly Ala Leu Val Leu Glu Ser Ala Ala Leu Leu His Trp Leu
   1               5                  10                  15    
 Glu Arg Glu Gly Tyr Gly Pro Leu Gly Met Thr Gly Ile Ser Met Gly
              20                  25                  30        
 Gly His Met Ala Ser Leu Ala Val Ser Asn Trp Pro Lys Pro Met Pro
          35                  40                  45            
 Leu Ile Pro Cys Leu Ser Trp Ser Thr Ala Ser Gly Val Phe Thr Thr
      50                  55                  60                
 Gly Val Leu Ser Lys Ser Ile Asn Trp Arg Glu Leu Glu Lys Gln Tyr
  65                  70                  75                  80
 Tyr Thr Gln Thr Val Tyr Glu Glu Glu Ile Ile His Met Leu Glu Tyr
                  85                  90                  95    
 Cys Gly Thr Asp Ser Phe Lys Met Gly Gln Glu Phe Val Lys His Phe
             100                 105                 110        
 Thr Ser Ser Ala Asp Lys Leu Thr Asn Leu Asn Leu Val Ser Arg Thr
         115                 120                 125            
 Leu Asn Leu Asp Ile Ser Asn Gln Val Val Ser Gln Lys Pro Ala Asp
     130                 135                 140                
 Cys His Asn Ser Ser Lys Thr Ser Val Ser Ala Thr Ser Glu Gly Leu
 145                 150                 155                 160
 Leu Leu Gln Asp Thr Ser Lys Met Lys Arg Phe Asn Gln Thr Leu Ser
                 165                 170                 175    
 Thr Asn Lys Ser Gly Tyr Thr Ser Arg Asn Pro Gln Ser Tyr His Leu
             180                 185                 190        
 Leu Ser Lys Glu Gln Ser Arg Asn Ser Leu Arg Lys Glu Ser Leu Ile
         195                 200                 205            
 Phe Met Lys Gly Val Met Asp Glu Cys Thr His Val Ala Asn Phe Ser
     210                 215                 220                
 Val Pro Val Asp Pro Ser Leu Ile Ile Val Val Gln Ala Lys Glu Asp
 225                 230                 235                 240
 Ala Tyr Ile Pro Arg Thr Gly Val Arg Ser Leu Gln Glu Ile Trp Pro
                 245                 250                 255    
 Gly Cys Glu Ile Arg Tyr Leu Glu Gly Gly His Ile Ser Ala Tyr Leu
             260                 265                 270        
 Phe Lys Gln Gly Leu Phe Arg
         275                



      <210> 727
      <211> 209
      <212> PRT
      <213> Homo sapiens


      <400> 727
 Met Thr Lys Gln Ser Ser Asn Pro Thr Ser Glu Tyr Ala Ser Glu Gly
   1               5                  10                  15    
 Asn Gly Tyr Phe Gln Glu Leu Ser Ala Leu Pro Arg Leu Leu Gln Cys
              20                  25                  30        
 Tyr Ser His Gln Pro Arg His Val Ser Arg Met Arg Val Leu His Asp
          35                  40                  45            
 Ala Arg Ile Asn Thr Leu Asp Phe Ile Leu Ile Leu Glu Ala Val Lys
      50                  55                  60                
 Lys Arg Ser Phe Leu Glu Thr Val Lys Lys Arg Ser Arg Gln Glu Glu
  65                  70                  75                  80
 Thr Ser Lys Arg Met Ser Pro Ser Gly Asp Ser His Ile Gln Ser Thr
                  85                  90                  95    
 Asn Ser Leu Asn Asn Ile Asp Gly Ser Arg Gly Glu Thr Arg Lys Val
             100                 105                 110        
 Val Arg Gly Val Ser Ile Gly Ser Thr Cys Leu Leu Ser Val Ser Gln
         115                 120                 125            
 Ala Ile Thr Ile Ser Pro Arg Ser Ser Gly Gly Gln Ser Leu Lys Gly
     130                 135                 140                
 Thr Pro Pro Ser Thr Leu Ala Pro Val Cys Ser Ser Ala Gly Ser Ser
 145                 150                 155                 160
 Leu Val Asn Ile Ile Val Leu Met His Val Thr Gly Lys Trp Ser Asn
                 165                 170                 175    
 Lys Asn Thr Thr Lys Thr Lys Asp Leu Gly Tyr Cys Ser Ala Ala Asp
             180                 185                 190        
 His Glu Gly Thr Arg Glu Ser Leu Thr Arg His Cys Cys Pro Ser Leu
         195                 200                 205            
 Met
    



      <210> 728
      <211> 76
      <212> PRT
      <213> Homo sapiens


      <400> 728
 Met Lys Val Ser Glu Arg Met Arg Leu Ser Tyr Glu Arg Arg Gly Arg
   1               5                  10                  15    
 Ser Gln Gly Gly Gly Ser His Pro Ala Gly Ala Gln Pro Gly Gly Arg
              20                  25                  30        
 Ala Ile Gly Ala Gly Trp Gln Ser Lys Glu Pro Leu Trp Glu Gly Leu
          35                  40                  45            
 Gln Arg Ser Gly Ser Pro Leu Pro Gly Asp Arg Ile Ile Val Glu Cys
      50                  55                  60                
 Leu Glu Gly Gly Gly Ser Phe Val Glu Phe Thr Lys
  65                  70                  75    



      <210> 729
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 729
 Met Ser Val Trp Trp Ser Ser Gln Arg Lys Thr Pro Gly Ala Gly Glu
   1               5                  10                  15    
 Leu Cys Met Asp Met Gln Ser Arg Ala Ala His Leu Leu Leu Leu Thr
              20                  25                  30        
 Leu Pro Val Pro Val Arg Val Cys Thr His Pro Asp Ser Val Ser Gln
          35                  40                  45            
 Glu Leu Gly Gln Ala Gln Leu Gly His Ser Ser Leu Leu His Leu Met
      50                  55                  60                
 Ser Ala Ala Ala Ser
  65                



      <210> 730
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 730
 Met Pro Trp Pro Arg Pro Val Arg Arg Leu Leu Ala Ser Pro Asn Pro
   1               5                  10                  15    
 Cys Arg Trp Val Thr Ser Arg Glu Ala Trp Arg Gly Leu Leu Arg Thr
              20                  25                  30        
 Pro Lys Ala Leu Gly Leu Glu Gln Glu Lys Gly Ser Gly Gly Ala Ser
          35                  40                  45            
 Glu Thr Met Lys Arg Gly Ile Arg Arg Asp Pro Phe Arg Lys Arg Lys
      50                  55                  60                
 Leu Gly Gly Arg Ala Lys Lys Val Arg Glu Pro Thr Ala Val Asn Ser
  65                  70                  75                  80
 Phe Tyr Arg Glu Ala Ser Leu Pro Ser Val Trp Ala Ser Leu Arg Arg
                  85                  90                  95    
 Arg Glu Met Val Arg Ser Gly Ala Arg Pro Gly Gln Val Arg Ala Glu
             100                 105                 110        
 Asp Leu Arg Ser Pro Leu Trp Gly Trp Arg Gly Thr Gly Gly Phe Ser
         115                 120                 125            
 Gly Gln Glu Leu Val Lys Leu Cys Ser Lys Lys Asp Lys Asp Asn Ala
     130                 135                 140                
 Ala Thr Leu Lys Cys Trp Asp Arg Gly Ala Gly Asn Thr
 145                 150                 155        



      <210> 731
      <211> 305
      <212> PRT
      <213> Homo sapiens


      <400> 731
 Met Gly Tyr Lys Leu Gln Asp Leu Thr Asp Val Gln Ile Met Ala Arg
   1               5                  10                  15    
 Leu Gln Glu Glu Ser Leu Arg Gln Asp Tyr Ala Ser Thr Ser Ala Ser
              20                  25                  30        
 Val Ser Arg His Ser Ser Ser Val Ser Leu Ser Ser Gly Lys Lys Gly
          35                  40                  45            
 Thr Cys Ser Asp Gln Glu Tyr Asp Gln Tyr Ser Leu Glu Asp Glu Glu
      50                  55                  60                
 Glu Phe Asp His Leu Pro Pro Pro Gln Pro Arg Leu Pro Arg Cys Ser
  65                  70                  75                  80
 Pro Phe Gln Arg Gly Ile Pro His Ser Gln Thr Phe Ser Ser Ile Arg
                  85                  90                  95    
 Glu Cys Arg Arg Ser Pro Ser Ser Gln Tyr Phe Pro Ser Asn Asn Tyr
             100                 105                 110        
 Gln Gln Gln Gln Tyr Tyr Ser Pro Gln Ala Gln Thr Pro Asp Gln Gln
         115                 120                 125            
 Pro Asn Arg Thr Asn Gly Asp Lys Leu Arg Arg Ser Met Pro Asn Leu
     130                 135                 140                
 Ala Arg Met Pro Ser Thr Thr Ala Ile Ser Ser Asn Ile Ser Ser Pro
 145                 150                 155                 160
 Val Thr Val Arg Asn Ser Gln Ser Phe Asp Ser Ser Leu His Gly Ala
                 165                 170                 175    
 Gly Asn Gly Ile Ser Arg Ile Gln Ser Cys Ile Pro Ser Pro Gly Gln
             180                 185                 190        
 Leu Gln His Arg Val His Ser Val Gly His Phe Pro Val Ser Ile Arg
         195                 200                 205            
 Gln Pro Leu Lys Ala Thr Ala Tyr Val Ser Pro Thr Val Gln Gly Ser
     210                 215                 220                
 Ser Asn Met Pro Leu Ser Asn Gly Leu Gln Leu Tyr Ser Asn Thr Gly
 225                 230                 235                 240
 Ile Pro Thr Pro Asn Lys Ala Ala Ala Ser Gly Ile Met Gly Arg Ser
                 245                 250                 255    
 Ala Leu Pro Arg Pro Ser Leu Ala Ile Asn Gly Ser Asn Leu Pro Arg
             260                 265                 270        
 Ser Lys Ile Ala Gln Pro Val Arg Ser Phe Leu Gln Pro Pro Lys Pro
         275                 280                 285            
 Leu Ser Ser Leu Ser Thr Leu Arg Asp Gly Asn Trp Arg Asp Gly Cys
     290                 295                 300                
 Tyr
 305



      <210> 732
      <211> 456
      <212> PRT
      <213> Homo sapiens


      <400> 732
 Met Ala Gly Leu Gln Arg Leu Ala Ser His Leu Pro Val Gly Val Met
   1               5                  10                  15    
 Leu Pro His Asn Thr Thr Glu Ala Pro Gly Pro His Ser Ala Lys Gln
              20                  25                  30        
 Asp Ser Tyr Glu Gln Gly Asp Ser Ser Gln Gln Ser Leu Lys Gly His
          35                  40                  45            
 Leu Arg Asn Asn Phe Gln Lys Gln Leu Leu Ser Asn Lys Glu Leu Ile
      50                  55                  60                
 Leu Asp Lys Val Tyr Thr His Pro Lys Trp Asn Thr Gln Thr Lys Ala
  65                  70                  75                  80
 Arg Ser Tyr Ser Tyr Pro His Cys Thr Gly Ile Ser Gln Gln Asp Pro
                  85                  90                  95    
 Glu Ser Asp Ser Gln Gly Gln Gly Asn Gly Leu Phe Tyr Ser Ser Gly
             100                 105                 110        
 Pro Gln Ser Trp Tyr Pro Lys Ala Asn Asn Gln Asp Phe Ile Pro Phe
         115                 120                 125            
 Thr Lys Lys Arg Val Gly Val Asp Arg Ala Phe Pro Leu Lys Pro Met
     130                 135                 140                
 Val His Arg Lys Ser Cys Ser Thr Gly Glu Ala Gly Thr Asp Gly Asp
 145                 150                 155                 160
 His Asn Val Tyr Pro Arg Pro Pro Glu Pro Arg Glu Phe Ser Ser Arg
                 165                 170                 175    
 Asn Phe Gly Val Arg Asn Gln Gly Asn Phe Ser Val Val Gly Thr Val
             180                 185                 190        
 Leu Ala Ala Thr Gln Ala Glu Lys Ala Val Ala Asn Phe Asp Arg Thr
         195                 200                 205            
 Glu Trp Val Gln Ile Arg Arg Leu Glu Ala Ala Gly Glu Ser Leu Glu
     210                 215                 220                
 Glu Glu Ile Arg Arg Lys Gln Ile Leu Leu Arg Gly Lys Leu Lys Lys
 225                 230                 235                 240
 Thr Glu Glu Glu Leu Arg Arg Ile Gln Thr Gln Lys Glu Gln Ala Lys
                 245                 250                 255    
 Glu Asn Glu Asn Gly Glu Leu Gln Lys Ile Ile Leu Pro Arg Ser Arg
             260                 265                 270        
 Val Lys Gly Asn Lys Ser Asn Thr Met Tyr Lys Pro Ile Phe Ser Pro
         275                 280                 285            
 Glu Phe Glu Phe Glu Glu Glu Phe Ser Arg Asp Arg Arg Glu Asp Glu
     290                 295                 300                
 Thr Trp Gly Arg Ser Gln Gln Asn Ser Gly Pro Phe Gln Phe Ser Asp
 305                 310                 315                 320
 Tyr Arg Ile Gln Arg Leu Lys Arg Glu Arg Leu Val Ala Ser Asn Asn
                 325                 330                 335    
 Lys Ile Arg Asp Pro Val Ser Glu Pro Ser Val Glu Lys Phe Ser Pro
             340                 345                 350        
 Pro Ser Glu Thr Pro Val Gly Ala Leu Gln Gly Ser Ala Arg Asn Ser
         355                 360                 365            
 Ser Leu Ser Met Ala Pro Asp Ser Ser Gly Ser Ser Gly Ser Ile Glu
     370                 375                 380                
 Glu Pro Gln Leu Gly Glu Cys Ser His Cys Gly Arg Lys Phe Leu Ser
 385                 390                 395                 400
 Phe Arg Leu Glu Arg His Ser Asn Ile Cys Ser Arg Met Arg Gly Ser
                 405                 410                 415    
 Lys Arg Lys Val Phe Asp Ser Ser Arg Ala Arg Ala Lys Gly Thr Glu
             420                 425                 430        
 Leu Glu Gln Tyr Leu Asn Trp Lys Gly Pro Ala Ser Ala Lys Ala Glu
         435                 440                 445            
 Pro Pro Gln Lys Ser Asn Trp Arg
     450                 455    



      <210> 733
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 733
 Met Trp Asn Thr Ser Glu Ala Ser Lys Asn His Pro Leu Ile Gln Glu
   1               5                  10                  15    
 Gly Gln Gly Glu Arg Pro Tyr Arg Asp Val Asp Met Leu Asp Val Pro
              20                  25                  30        
 Arg Leu Ser Glu Pro Pro Phe Pro Gln His Pro Ser Leu Gln Ser Ile
          35                  40                  45            
 Tyr Phe Thr Ser Ala Leu Ser Gly Thr Asp Gly Arg
      50                  55                  60



      <210> 734
      <211> 577
      <212> PRT
      <213> Homo sapiens


      <400> 734
 Met Glu Tyr His Ser Pro Asp Asp Asn Arg Met Asn Arg Asn Arg Leu
   1               5                  10                  15    
 Leu His Ile Asn Leu Gly Ile His Ser Pro Ser Ser Tyr His Pro Gly
              20                  25                  30        
 Asp Gly Ala Gln Leu Asn Gly Gly Arg Thr Leu Val His Ser Ser Ser
          35                  40                  45            
 Asp Gly His Ile Asp Pro Gln His Ala Ala Gly Lys Gln Leu Ile Cys
      50                  55                  60                
 Leu Val Gln Glu Pro His Ser Ala Pro Ala Val Val Ala Ala Thr Pro
  65                  70                  75                  80
 Asn Tyr Asn Pro Phe Phe Met Asn Glu Gln Asn Arg Ser Ala Ala Thr
                  85                  90                  95    
 Pro Pro Ser Gln Pro Pro Gln Gln Pro Ser Ser Met Gln Thr Gly Met
             100                 105                 110        
 Asn Pro Ser Ala Met Gln Gly Pro Ser Pro Pro Pro Pro Pro Pro Ser
         115                 120                 125            
 Tyr Met His Ile Pro Arg Tyr Ser Thr Asn Pro Ile Thr Val Thr Val
     130                 135                 140                
 Ser Gln Asn Leu Pro Ser Gly Gln Thr Val Pro Arg Ala Leu Gln Ile
 145                 150                 155                 160
 Leu Pro Gln Ile Pro Ser Asn Leu Tyr Gly Ser Pro Gly Ser Ile Tyr
                 165                 170                 175    
 Ile Arg Gln Thr Ser Gln Ser Ser Ser Gly Arg Gln Thr Pro Gln Ser
             180                 185                 190        
 Thr Pro Trp Gln Ser Ser Pro Gln Gly Pro Val Pro His Tyr Ser Gln
         195                 200                 205            
 Arg Pro Leu Pro Val Tyr Pro His Gln Gln Asn Tyr Gln Pro Ser Gln
     210                 215                 220                
 Tyr Ser Pro Lys Gln Gln Gln Ile Pro Gln Ser Ala Tyr His Ser Pro
 225                 230                 235                 240
 Pro Pro Ser Gln Cys Pro Ser Pro Phe Ser Ser Pro Gln His Gln Val
                 245                 250                 255    
 Gln Pro Ser Gln Leu Gly His Ile Phe Met Pro Pro Ser Pro Ser Thr
             260                 265                 270        
 Thr Pro Pro His Pro Tyr Gln Gln Gly Pro Pro Ser Tyr Gln Lys Gln
         275                 280                 285            
 Gly Ser His Ser Val Ala Tyr Leu Pro Tyr Thr Ala Ser Ser Leu Ser
     290                 295                 300                
 Lys Gly Ser Met Lys Lys Ile Glu Ile Thr Val Glu Pro Ser Gln Arg
 305                 310                 315                 320
 Pro Gly Thr Ala Ile Asn Arg Ser Pro Ser Pro Ile Ser Asn Gln Leu
                 325                 330                 335    
 Ser Pro Arg Asn Gln His Ser Leu Tyr Thr Ala Thr Thr Pro Pro Ser
             340                 345                 350        
 Ser Ser Pro Ser Arg Gly Ile Ser Ser Gln Pro Lys Pro Pro Phe Ser
         355                 360                 365            
 Val Asn Pro Val Tyr Ile Thr Tyr Thr Gln Pro Thr Gly Pro Ser Cys
     370                 375                 380                
 Thr Pro Ser Pro Ser Pro Arg Val Ile Pro Asn Pro Thr Thr Val Phe
 385                 390                 395                 400
 Lys Ile Thr Val Gly Arg Ala Thr Thr Glu Asn Leu Leu Asn Leu Val
                 405                 410                 415    
 Asp Gln Glu Glu Arg Ser Ala Ala Pro Glu Pro Ile Gln Pro Ile Ser
             420                 425                 430        
 Val Ile Pro Gly Ser Gly Gly Glu Lys Gly Ser His Lys Tyr Gln Arg
         435                 440                 445            
 Ser Ser Ser Ser Gly Ser Asp Asp Tyr Ala Tyr Thr Gln Ala Leu Leu
     450                 455                 460                
 Leu His Gln Arg Ala Arg Met Glu Arg Leu Ala Lys Gln Leu Lys Leu
 465                 470                 475                 480
 Glu Lys Glu Glu Leu Glu Arg Leu Lys Ser Glu Val Asn Gly Met Glu
                 485                 490                 495    
 His Asp Leu Met Gln Arg Arg Leu Arg Arg Val Ser Cys Thr Thr Ala
             500                 505                 510        
 Ile Pro Thr Pro Glu Glu Met Thr Arg Leu Arg Ser Met Asn Arg Gln
         515                 520                 525            
 Leu Gln Ile Asn Val Asp Cys Thr Leu Lys Glu Val Asp Leu Leu Gln
     530                 535                 540                
 Ser Arg Glu Val Tyr Tyr Ser Arg Ser Ser Leu Lys Leu Ser Phe Thr
 545                 550                 555                 560
 Gln Leu Thr Arg Leu Glu Met Val Phe Ile Phe Cys Gly Lys Tyr Thr
                 565                 570                 575    
 Asp
    



      <210> 735
      <211> 111
      <212> PRT
      <213> Homo sapiens


      <400> 735
 Met Ala Leu Pro Arg Leu Thr Gly Ala Leu Arg Ser Phe Ser Asn Val
   1               5                  10                  15    
 Thr Lys Gln Asp Asn Tyr Asn Glu Glu Val Ala Asp Leu Lys Ile Lys
              20                  25                  30        
 Arg Ser Lys Leu His Glu Gln Val Leu Asp Leu Gly Leu Thr Trp Lys
          35                  40                  45            
 Lys Ile Ile Lys Phe Leu Asn Glu Lys Leu Glu Lys Ser Lys Met Gln
      50                  55                  60                
 Ser Ile Asn Glu Asp Leu Lys Asp Ile Leu His Ala Ala Lys Gln Ile
  65                  70                  75                  80
 Glu Val Asn Cys Pro Phe Gln Lys Arg Arg Leu Asp Gly Lys Glu Glu
                  85                  90                  95    
 Asp Glu Lys Met Ser Arg Ala Ser Asp Arg Phe Arg Gly Leu Arg
             100                 105                 110    



      <210> 736
      <211> 599
      <212> PRT
      <213> Homo sapiens


      <400> 736
 Met Ser Asn Cys Gln Arg Lys Val Ala Val Glu Ala Val Ile Gln Ser
   1               5                  10                  15    
 His Leu Asp Val Lys Lys Lys Gly Phe Lys Asn Lys Asn Lys Asp Ala
              20                  25                  30        
 Ser Lys Asn Leu Asn Leu Ser Asn Glu Glu Thr Asp Gln Ser Glu Ile
          35                  40                  45            
 Arg Met Ser Gly Thr Cys Thr Gly Gln Pro Ser Ser Arg Thr Ser Gln
      50                  55                  60                
 Lys Leu Leu Ser Leu Thr Lys Val Ser Ser Pro Ala Gly Pro Thr Glu
  65                  70                  75                  80
 Asp Asn Asp Leu Ser Arg Lys Ala Val Ala Gln Ala Pro Gly Arg Arg
                  85                  90                  95    
 Tyr Thr Gly Lys Arg Lys Ser Ala Cys Thr Pro Ala Ser Asp His Cys
             100                 105                 110        
 Glu Pro Leu Leu Pro Thr Ser Ser Leu Ser Ile Val Asn Arg Ser Lys
         115                 120                 125            
 Glu Glu Val Thr Ser His Lys Tyr Gln His Glu Lys Leu Phe Ile Gln
     130                 135                 140                
 Val Lys Gly Lys Lys Ser Arg His Gln Lys Glu Asp Ser Leu Ser Trp
 145                 150                 155                 160
 Ser Asn Ser Ala Tyr Leu Ser Leu Asp Asp Asp Ala Phe Thr Ala Pro
                 165                 170                 175    
 Phe His Arg Asp Gly Met Leu Ser Leu Lys Gln Leu Leu Ser Phe Leu
             180                 185                 190        
 Ser Ile Thr Asp Phe Gln Leu Pro Asp Glu Asp Phe Gly Pro Leu Lys
         195                 200                 205            
 Leu Glu Lys Val Lys Ser Cys Ser Glu Lys Pro Val Glu Pro Phe Glu
     210                 215                 220                
 Ser Lys Met Phe Gly Glu Arg His Leu Lys Glu Gly Ser Cys Ile Phe
 225                 230                 235                 240
 Pro Glu Glu Leu Ser Pro Lys Arg Met Asp Thr Glu Met Glu Asp Leu
                 245                 250                 255    
 Glu Glu Asp Leu Ile Val Leu Pro Gly Lys Ser His Pro Lys Arg Pro
             260                 265                 270        
 Asn Ser Gln Ser Gln His Thr Lys Thr Gly Leu Ser Ser Ser Ile Leu
         275                 280                 285            
 Leu Tyr Thr Pro Leu Asn Thr Val Ala Pro Asp Asp Asn Asp Arg Pro
     290                 295                 300                
 Thr Thr Asp Met Cys Ser Pro Ala Phe Pro Ile Leu Gly Thr Thr Pro
 305                 310                 315                 320
 Ala Phe Gly Pro Gln Gly Ser Tyr Glu Lys Ala Ser Thr Glu Val Ala
                 325                 330                 335    
 Gly Arg Thr Cys Cys Thr Pro Gln Leu Ala His Leu Lys Asp Ser Val
             340                 345                 350        
 Cys Leu Ala Ser Asp Thr Lys Gln Phe Asp Ser Ser Gly Ser Pro Ala
         355                 360                 365            
 Lys Pro His Thr Thr Leu Gln Val Ser Gly Arg Gln Gly Gln Pro Thr
     370                 375                 380                
 Cys Asp Cys Asp Ser Val Pro Pro Gly Thr Pro Pro Pro Ile Glu Ser
 385                 390                 395                 400
 Phe Thr Phe Lys Glu Asn Gln Leu Cys Arg Asn Thr Cys Gln Glu Leu
                 405                 410                 415    
 His Lys His Ser Val Glu Gln Thr Glu Thr Ala Glu Leu Pro Ala Ser
             420                 425                 430        
 Asp Ser Ile Asn Pro Gly Asn Leu Gln Leu Val Ser Glu Leu Lys Asn
         435                 440                 445            
 Pro Ser Gly Ser Cys Ser Val Asp Val Ser Ala Met Phe Trp Glu Arg
     450                 455                 460                
 Ala Gly Cys Lys Glu Pro Cys Ile Ile Thr Ala Cys Glu Asp Val Val
 465                 470                 475                 480
 Ser Leu Trp Lys Ala Leu Asp Ala Trp Gln Trp Glu Lys Leu Tyr Thr
                 485                 490                 495    
 Trp His Phe Ala Glu Val Pro Val Leu Gln Ile Val Pro Val Pro Asp
             500                 505                 510        
 Val Tyr Asn Leu Val Cys Val Ala Leu Gly Asn Leu Glu Ile Arg Glu
         515                 520                 525            
 Ile Arg Ala Leu Phe Cys Ser Ser Asp Asp Glu Ser Glu Lys Gln Val
     530                 535                 540                
 Leu Leu Lys Ser Gly Asn Ile Lys Ala Val Leu Gly Leu Thr Lys Arg
 545                 550                 555                 560
 Arg Leu Val Ser Ser Ser Gly Thr Leu Ser Asp Gln Gln Val Glu Val
                 565                 570                 575    
 Met Thr Phe Ala Glu Asp Gly Gly Gly Lys Glu Asn Gln Phe Leu Met
             580                 585                 590        
 Pro Pro Glu Glu Thr Asn Asn
         595                



      <210> 737
      <211> 78
      <212> PRT
      <213> Homo sapiens


      <400> 737
 Met Asp Leu Ile Lys Arg Asn Ser Gly Trp Val Phe Glu Asn Pro Ser
   1               5                  10                  15    
 Ile Gly Val Leu Glu Leu Trp Val Leu Ala Thr Asn Phe Arg Asp Tyr
              20                  25                  30        
 Ala Ile Ile Phe Thr Gln Leu Glu Phe Gly Asp Glu Pro Phe Asn Thr
          35                  40                  45            
 Val Glu Leu Tyr Ser Leu Thr Glu Thr Ala Ser Gln Glu Ala Met Gly
      50                  55                  60                
 Leu Phe Thr Lys Trp Ser Arg Ser Leu Gly Phe Leu Ser Gln
  65                  70                  75            



      <210> 738
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 738
 Met Gly Ile Gln Ser Gly Lys Asn Phe Ile Asn Thr Asn Ala Ala Asp
   1               5                  10                  15    
 Ile Ile Met Gly Val Ala Lys Lys Pro Lys Pro Ile Tyr Val Asp Lys
              20                  25                  30        
 Arg Thr Gly Asp Lys His Asp Leu Glu Pro Ser Gly Leu Val Pro Lys
          35                  40                  45            
 Tyr Ile Asn Lys Lys Asp Tyr Gly Val Thr Pro Glu Tyr Ile Cys Lys
      50                  55                  60                
 Arg Asn Glu Glu Ile Lys Lys Ala Gln Glu Asp Tyr Asp Arg Tyr Ile
  65                  70                  75                  80
 Gln Glu Asn Leu Lys Lys Ala Ala Met Lys Arg Leu Ser Asp Glu Glu
                  85                  90                  95    
 Arg Glu Ala Val Leu Gln Gly Leu Lys Lys Asn Trp Glu Glu Val His
             100                 105                 110        
 Lys Glu Phe Gln Ser Leu Ser Val Phe Ile Asp Ser Ile Pro Lys Lys
         115                 120                 125            
 Ile Arg Lys Gln Arg Leu Glu Glu Glu Met Lys Gln Leu Glu His Asp
     130                 135                 140                
 Ile Gly Ile Ile Glu Lys His Lys Ile Ile Tyr Ile Ala Asn Lys
 145                 150                 155                



      <210> 739
      <211> 292
      <212> PRT
      <213> Homo sapiens


      <400> 739
 Met Asp Glu Thr Gln Gly Pro Leu Ala Met Thr Val His Leu Leu Ala
   1               5                  10                  15    
 Asn Ser Gly His Gly Ser Leu Leu Gln Arg Thr Leu Asp Gln Leu Leu
              20                  25                  30        
 Asp Cys Ile Cys Pro Glu Val Arg Leu Phe Gln Val Ser Glu Arg Ala
          35                  40                  45            
 Ser Pro Val Lys Tyr Cys Glu Lys Ser His Ser Lys Arg Ser Arg Phe
      50                  55                  60                
 Pro Gly Met Ser Val Leu Leu Phe Leu His Glu Ser Pro Gly Glu Asp
  65                  70                  75                  80
 Arg Leu Phe Arg Val Leu Asp Ser Leu Gln His Ser Pro Trp Gln Cys
                  85                  90                  95    
 Tyr Pro Thr Gln Asp Thr Arg Gly Arg Leu Cys Pro Tyr Phe Phe Ala
             100                 105                 110        
 Asn Gln Glu Phe Tyr Ser Leu Asp Ser Gln Leu Pro Ile Trp Gly Val
         115                 120                 125            
 Arg Gln Val His Cys Gly Ser Glu Ile Leu Arg Val Thr Leu Tyr Cys
     130                 135                 140                
 Ser Phe Asp Asn Tyr Glu Asp Ala Ile Arg Leu Tyr Glu Met Ile Leu
 145                 150                 155                 160
 Gln Arg Glu Ala Thr Leu Gln Lys Ser Asn Phe Cys Phe Phe Val Leu
                 165                 170                 175    
 Tyr Ala Ser Lys Ser Phe Ala Leu Gln Leu Ser Leu Lys Gln Leu Pro
             180                 185                 190        
 Pro Gly Met Ser Val Asp Pro Lys Glu Ser Ser Val Leu Gln Phe Lys
         195                 200                 205            
 Val Gln Glu Ile Gly Gln Leu Val Pro Leu Leu Pro Asn Pro Cys Met
     210                 215                 220                
 Pro Ile Ser Ser Thr Arg Trp Gln Thr Gln Asp Tyr Asp Gly Asn Lys
 225                 230                 235                 240
 Ile Leu Leu Gln Pro Gly Ile Arg Gln Gly Arg Gln Leu Ala Ala Ser
                 245                 250                 255    
 Ser Ser Glu Gly Tyr Ile Leu His Val Asp Ser Lys Cys Leu Ala Pro
             260                 265                 270        
 Pro Trp Arg Asn Lys Met Ser Gly Leu Gln Leu Asp Gln Leu Gly Ser
         275                 280                 285            
 Asp Ser Leu Leu
     290        



      <210> 740
      <211> 67
      <212> PRT
      <213> Homo sapiens


      <400> 740
 Met His Thr Tyr Pro Glu Phe Cys Thr Tyr Val Gln Arg Phe Leu Asp
   1               5                  10                  15    
 Leu Gln Thr Cys Leu Cys Val Ser Gln Phe Lys Asn Leu Cys Ser Phe
              20                  25                  30        
 Phe Met Thr Gly Phe Ala Gln Phe Cys Val Ile Leu Gly Leu Asn Leu
          35                  40                  45            
 Ser Leu Phe Gly Thr Phe Pro Tyr Leu Leu Pro Ser Ser Glu Ser Arg
      50                  55                  60                
 Cys Arg Lys
  65        



      <210> 741
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 741
 Met Thr Ser Gln Pro Val Pro Asn Glu Thr Ile Ile Val Leu Pro Ser
   1               5                  10                  15    
 Asn Val Ile Asn Phe Ser Gln Ala Glu Lys Pro Glu Pro Thr Asn Gln
              20                  25                  30        
 Gly Gln Asp Ser Leu Lys Lys His Leu His Ala Glu Ile Lys Val Ile
          35                  40                  45            
 Gly Thr Ile Gln Ile Leu Cys Gly Met Met Val Leu Ser Leu Gly Ile
      50                  55                  60                
 Ile Leu Ala Ser Ala Ser Phe Ser Pro Asn Phe Thr Gln Val Thr Ser
  65                  70                  75                  80
 Thr Leu Leu Asn Ser Ala Tyr Pro Phe Ile Gly Pro Phe Phe Phe Ile
                  85                  90                  95    
 Ile Ser Gly Ser Leu Ser Ile Ala Thr Glu Lys Arg Leu Thr Lys Leu
             100                 105                 110        
 Leu Val His Ser Ser Leu Val Gly Ser Ile Leu Ser Ala Leu Ser Ala
         115                 120                 125            
 Leu Val Gly Phe Ile Ile Leu Ser Val Lys Gln Ala Thr Leu Asn Pro
     130                 135                 140                
 Ala Ser Leu Gln Cys Glu Leu Asp Asn Thr Thr Asp Cys Tyr Thr Ala
 145                 150                 155                 160
 Lys Ala Ser Leu Ala Gly Ser Leu Ser Leu Met Leu Ile Cys Thr Leu
                 165                 170                 175    
 Leu Glu Phe Cys Leu Ala Val Leu Thr Ala Val Leu Arg Trp Lys Gln
             180                 185                 190        
 Ala Tyr Ser Asp Phe Pro Gly Ser Val Leu Phe Leu Pro His Ser Tyr
         195                 200                 205            
 Ile Gly Asn Ser Gly Met Ser Ser Lys Met Thr His Asp Cys Gly Tyr
     210                 215                 220                
 Glu Glu Leu Leu Thr Ser
 225                 230



      <210> 742
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 742
 Met Thr Ser Gln Pro Val Pro Asn Glu Thr Ile Ile Val Leu Pro Ser
   1               5                  10                  15    
 Asn Val Ile Asn Phe Ser Gln Ala Glu Lys Pro Glu Pro Thr Asn Gln
              20                  25                  30        
 Gly Gln Asp Ser Leu Lys Lys His Leu His Ala Glu Ile Lys Val Ile
          35                  40                  45            
 Gly Phe Ile Ile Ser Gly Ser Leu Ser Ile Ala Thr Glu Lys Arg Leu
      50                  55                  60                
 Thr Lys Leu Leu Val His Ser Ser Leu Val Gly Ser Ile Leu Ser Ala
  65                  70                  75                  80
 Leu Ser Ala Leu Val Gly Phe Ile Ile Leu Ser Val Lys Gln Ala Thr
                  85                  90                  95    
 Leu Asn Pro Ala Ser Leu Gln Cys Glu Leu Asp Asn Thr Thr Asp Cys
             100                 105                 110        
 Tyr Thr Ala Lys Ala Ser Leu Ala Gly Ser Leu Ser Leu Met Leu Ile
         115                 120                 125            
 Cys Thr Leu Leu Glu Phe Cys Leu Ala Val Leu Thr Ala Val Leu Arg
     130                 135                 140                
 Trp Lys Gln Ala Tyr Ser Asp Phe Pro Gly Ser Val Leu Phe Leu Pro
 145                 150                 155                 160
 His Ser Tyr Ile Gly Asn Ser Gly Met Ser Ser Lys Met Thr His Asp
                 165                 170                 175    
 Cys Gly Tyr Glu Glu Leu Leu Thr Ser
             180                 185



      <210> 743
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 743
 Met Pro Glu Gly Pro Trp Pro Ala Asp Ala Pro Ser Trp Met Asn Lys
   1               5                  10                  15    
 Pro Val Val Asp Gly Asn Ser Gln Ser Glu Ala Leu Ser Leu Glu Met
              20                  25                  30        
 Arg Lys Asp Pro Ser Gly Ala Gly Leu Trp Leu His Ser Gly Gly Pro
          35                  40                  45            
 Val Leu Pro Tyr Val Arg Glu Ser Val Arg Arg Asn Pro Ala Ser Ala
      50                  55                  60                
 Ala Thr Pro Ser Thr Ala Val Gly Leu Phe Pro Ala Pro Thr Glu Cys
  65                  70                  75                  80
 Phe Ala Arg Val Ser Cys Ser Gly Val Glu Ala Leu Gly Gln Arg Asp
                  85                  90                  95    
 Trp Leu Gly Gly Gly Pro Arg Ala Thr Asp Gly His Arg Gly Gln Cys
             100                 105                 110        
 Pro Lys Gly Glu Pro Arg Val Ser Arg Leu Pro Arg His Gln Lys Leu
         115                 120                 125            
 Pro Glu Met Gly Ser Phe Gln Asp Asp Pro Pro Ser Ala Phe Pro Lys
     130                 135                 140                
 Gly Leu Gly Ser Glu Leu Glu Pro Ala Cys Leu His Ser Ile Leu Ser
 145                 150                 155                 160
 Ala Thr Leu His Met Tyr Pro Glu Val Leu Leu Ser Glu Glu Thr Lys
                 165                 170                 175    
 Arg Ile Phe Leu Asp Arg Leu Lys Pro Met Phe Ser Lys Gln Thr Ile
             180                 185                 190        
 Glu Phe Lys Lys Met Leu Lys Ser Thr Ser Asp Gly Leu Gln Ile Thr
         195                 200                 205            
 Leu Gly Leu Leu Ala Leu Gln Pro Phe Glu Leu Ala Asn Thr Leu Cys
     210                 215                 220                
 His Ser
 225    



      <210> 744
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 744
 Met Thr Tyr Phe Gly His Phe Gly Gly Ala Asn His Ala His Thr Leu
   1               5                  10                  15    
 Gly Glu Leu Glu Ala Cys Ile Ala Met Leu Val Glu Gln Leu Arg Thr
              20                  25                  30        
 Gln Gly Cys Gly Gly Arg Thr Leu Gly Thr Ser Glu Glu Glu Ala Glu
          35                  40                  45            
 Leu Gln Gln Lys Val Glu Glu Asn Glu His Leu Arg Leu Glu Leu Gln
      50                  55                  60                
 Met Val Glu Thr Glu Arg Val Arg Leu Ser Leu Leu Glu Glu Lys Leu
  65                  70                  75                  80
 Val Asp Val Leu Gln Leu Leu Gln Arg Leu Arg Asp Leu Asn Ile Ser
                  85                  90                  95    
 Lys Arg Ala Leu Gly Lys Ile Leu Leu Ser Thr Leu Asp Ala Phe Arg
             100                 105                 110        
 Asp Pro Thr His Glu Gly Arg Pro Ser Pro Ala Ala Ile Leu Asp Ala
         115                 120                 125            
 Leu His Gln Ala Leu Ala Ala Cys Gln Leu Leu Arg Arg Gln Pro Ser
     130                 135                 140                
 Ala Pro Ala Ser Ala Ala Ala Ala Leu Thr Asn Pro Leu Leu Val Ser
 145                 150                 155                 160
 Cys
    



      <210> 745
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 745
 Met Ala Ala Pro Val Leu Leu Arg Val Ser Val Pro Arg Trp Glu Arg
   1               5                  10                  15    
 Val Ala Arg Tyr Ala Val Cys Ala Ala Gly Ile Leu Leu Ser Ile Tyr
              20                  25                  30        
 Ala Tyr His Val Glu Arg Glu Lys Glu Arg Asp Pro Glu His Arg Ala
          35                  40                  45            
 Leu Cys Asp Leu Gly Pro Trp Val Lys Cys Ser Ala Ala Leu Ala Ser
      50                  55                  60                
 Arg Trp Gly Arg Gly Phe Gly Leu Leu Gly Ser Ile Phe Gly Lys Asp
  65                  70                  75                  80
 Gly Val Leu Asn Gln Pro Asn Ser Val Phe Gly Leu Ile Phe Tyr Ile
                  85                  90                  95    
 Leu Gln Leu Leu Leu Gly Met Thr Ala Ser Ala Val Ala Ala Leu Ile
             100                 105                 110        
 Leu Met Thr Ser Ser Ile Met Ser Val Val Gly Ser Leu Tyr Leu Ala
         115                 120                 125            
 Tyr Ile Leu Tyr Phe Val Leu Lys Glu Phe Cys Ile Ile Cys Ile Val
     130                 135                 140                
 Thr Tyr Val Leu Asn Phe Leu Leu Leu Ile Ile Asn Tyr Lys Arg Leu
 145                 150                 155                 160
 Val Tyr Leu Asn Glu Ala Trp Lys Arg Gln Leu Gln Pro Lys Gln Asp
                 165                 170                 175    





      <210> 746
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 746
 Met Gly Arg Val Arg Asn Arg Ala Thr Ala Gln Arg Arg Arg Arg Lys
   1               5                  10                  15    
 Arg Pro Gly Asp Pro Pro Ala Ala Cys Ala Ala Ile Ala Val Thr Gly
              20                  25                  30        
 Ala Ser Arg Ala Gln Cys Pro Arg Val Gln Val Gly Val Gly Ser His
          35                  40                  45            
 Ala Ala Ala Lys Arg Trp Leu Gly Arg Trp Arg Arg Lys Arg Arg Trp
      50                  55                  60                
 Arg Arg Val Arg Lys Ala Gly Pro Arg Asp Leu Leu Pro Ser Ala Pro
  65                  70                  75                  80
 Thr Pro Asp Pro Pro Gly Pro Ala Pro Ser Pro Lys Asp Leu Asp Leu
                  85                  90                  95    
 Gly Ala Gln Arg Glu Arg Trp Glu Thr Phe Arg Lys Leu Arg Gly Leu
             100                 105                 110        
 Ser Cys Glu Gly Ala Ala Lys Val Leu Leu Asp Thr Phe Glu Tyr Pro
         115                 120                 125            
 Gly Leu Val His His Thr Gly Gly Cys His Cys Gly Ala Val Arg Phe
     130                 135                 140                
 Ala Val Trp Ala Pro Ala Asp Leu Arg Val Val Asp Cys Ser Cys Arg
 145                 150                 155                 160
 Leu Cys Arg Lys Lys Gln His Arg His Phe Leu Val Pro Ala Ser Arg
                 165                 170                 175    
 Phe Thr Leu Leu Gln Gly Ala Glu Ser Ile Val Thr Tyr Arg Ser Asn
             180                 185                 190        
 Thr His Pro Ala Leu His Ser Phe Cys Ser Arg Cys Gly Val Gln Ser
         195                 200                 205            
 Phe His Ala Ala Val Ser Asp Pro Arg Val Tyr Gly Val Ala Pro His
     210                 215                 220                
 Cys Leu Asp Glu Gly Thr Val Arg Ser Val Val Ile Glu Glu Val Gly
 225                 230                 235                 240
 Gly Gly Asp Pro Gly Glu Glu Ala Ala Lys Glu His Lys Ala Ile His
                 245                 250                 255    
 Lys Thr Ser Ser Gln Ser Ala Pro Ala Cys Pro Arg Glu Gln Glu Gln
             260                 265                 270        





      <210> 747
      <211> 211
      <212> PRT
      <213> Homo sapiens


      <400> 747
 Met Glu Glu Pro Pro Val Arg Glu Glu Glu Glu Glu Glu Gly Glu Glu
   1               5                  10                  15    
 Asp Glu Glu Arg Asp Glu Val Gly Pro Glu Gly Ala Leu Gly Lys Ser
              20                  25                  30        
 Pro Phe Gln Leu Thr Ala Glu Asp Val Tyr Asp Ile Ser Tyr Leu Leu
          35                  40                  45            
 Gly Arg Glu Leu Met Ala Leu Gly Ser Asp Pro Arg Val Thr Gln Leu
      50                  55                  60                
 Gln Phe Lys Val Val Arg Val Leu Glu Met Leu Glu Ala Leu Val Asn
  65                  70                  75                  80
 Glu Gly Ser Leu Ala Leu Glu Glu Leu Lys Met Glu Arg Asp His Leu
                  85                  90                  95    
 Arg Lys Glu Val Glu Gly Leu Arg Arg Gln Ser Pro Pro Ala Ser Gly
             100                 105                 110        
 Glu Val Asn Leu Gly Pro Asn Lys Met Val Val Asp Leu Thr Asp Pro
         115                 120                 125            
 Asn Arg Pro Arg Phe Thr Leu Gln Glu Leu Arg Asp Val Leu Gln Glu
     130                 135                 140                
 Arg Asn Lys Leu Lys Ser Gln Leu Leu Val Val Gln Glu Glu Leu Gln
 145                 150                 155                 160
 Cys Tyr Lys Ser Gly Leu Ile Pro Pro Arg Glu Gly Pro Gly Gly Arg
                 165                 170                 175    
 Arg Glu Lys Asp Ala Val Val Thr Ser Ala Lys Asn Ala Gly Arg Asn
             180                 185                 190        
 Lys Glu Glu Lys Thr Ile Ile Lys Lys Leu Phe Phe Phe Arg Ser Gly
         195                 200                 205            
 Lys Gln Thr
     210    



      <210> 748
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 748
 Met Lys Val Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile
   1               5                  10                  15    
 Gly Thr His Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys
              20                  25                  30        
 Gly Gln Gln Arg Glu Thr Arg Cys Ala Gly Gly Gln Arg Glu Trp Pro
          35                  40                  45            
 Glu Gly Lys Glu Tyr Val Asn Pro Phe Arg Asp Arg Ile Cys Arg Val
      50                  55                  60                
 Phe Ser His Lys Gly Met Phe Ser Phe Glu Asp Val Leu Gly Met Ala
  65                  70                  75                  80
 Ser Val Phe Ser Glu Gln Ala Cys Pro Ser Leu Lys Ile Glu Tyr Ala
                  85                  90                  95    
 Phe Arg Ile Tyr Ala Trp Gly Pro Ser Leu Ile Cys Gly Ser Thr Thr
             100                 105                 110        
 Pro Thr Val Ile Gly Arg Tyr Gln Gly Pro Arg Ser Pro Leu Trp Pro
         115                 120                 125            
 Ser Pro Leu Ala Leu Pro Thr Ala Pro Pro Pro Ser Ser Thr Ser Arg
     130                 135                 140                
 Thr Thr Ala Thr Glu Pro Trp Arg Arg Ala Thr Leu Pro Ser Ala Lys
 145                 150                 155                 160
 Ala Ala Ile Ser Pro Pro Ser Ser Pro Pro Thr Pro Thr Ser Cys
                 165                 170                 175



      <210> 749
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 749
 Met Ala Gly Ser Gln Asp Ile Phe Asp Ala Ile Val Met Ala Asp Glu
   1               5                  10                  15    
 Arg Phe His Gly Glu Gly Tyr Arg Glu Gly Tyr Glu Glu Gly Ser Ser
              20                  25                  30        
 Leu Gly Val Met Glu Gly Arg Gln His Gly Thr Leu His Gly Ala Lys
          35                  40                  45            
 Ile Gly Ser Glu Ile Gly Cys Tyr Gln Gly Phe Ala Phe Ala Trp Lys
      50                  55                  60                
 Cys Leu Leu His Ser Cys Thr Thr Glu Lys Asp Ser Arg Lys Met Lys
  65                  70                  75                  80
 Val Leu Glu Ser Leu Ile Gly Met Ile Gln Lys Phe Pro Tyr Asp Asp
                  85                  90                  95    
 Pro Thr Tyr Asp Lys Leu His Glu Asp Leu Asp Lys Ile Arg Gly Lys
             100                 105                 110        
 Phe Lys Gln Phe Cys Ser Leu Leu Asn Val Gln Pro Asp Phe Lys Ile
         115                 120                 125            
 Ser Ala Glu Gly Ser Gly Leu Ser Phe
     130                 135        



      <210> 750
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 750
 Met Ala Arg Glu Glu Glu Glu Gly Val Ser Phe Lys Pro Asp Val Leu
   1               5                  10                  15    
 Gly Gly Ser Arg Phe Leu Arg Ser Ala Asp Pro Ala His Ile Cys Pro
              20                  25                  30        
 Gln Asp Pro His Ser Ile Ile Phe Leu Cys Asp Leu His Ile His Phe
          35                  40                  45            
 Pro Ala Gly Val Ile Asp Ala Ile Arg Lys His Cys Val Glu Gly Lys
      50                  55                  60                
 Met Ala Phe Ala Pro Met Val Met Arg Leu His Cys Gly Ala Thr Pro
  65                  70                  75                  80
 Gln Trp Pro Glu Gly Tyr Trp Glu Val Asn Gly Phe Gly Leu Leu Gly
                  85                  90                  95    
 Ile Tyr Lys Ser Asp Leu Asp Arg Ile Gly Gly Met Asn Thr Lys Glu
             100                 105                 110        
 Phe Arg Asp Arg Trp Gly Gly Glu Asp Trp Glu Leu Leu Asp Arg Ile
         115                 120                 125            
 Leu Gln Ala Gly Leu Asp Val Glu Arg Leu Ser Leu Arg Asn Phe Phe
     130                 135                 140                
 His His Phe His Ser Lys Arg Gly Met Trp Ser Arg Arg Gln Met Lys
 145                 150                 155                 160
 Thr Leu
        



      <210> 751
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 751
 Met Ala Ala Arg Trp Arg Tyr Arg Thr Gly Cys Cys Ile Pro Glu Arg
   1               5                  10                  15    
 Ala Arg Arg Gly Ser Ala Ser Ser Trp Thr Ala Ser Glu Ala Ser Ala
              20                  25                  30        
 Pro Thr Ser Pro Thr Thr Asp Ala Gly Ala Ser Arg Ser Arg Gly Thr
          35                  40                  45            
 Gly Asp Arg Cys Arg Arg Arg Gly Leu Gly Ala Gly Pro Gly Val Ala
      50                  55                  60                
 Arg Lys Pro Gly Gly Gly Asn Gly Ser Gly Pro Thr Val Asp Met Pro
  65                  70                  75                  80
 Val Pro Ser Ser Phe Asn Asp Ile Gly Gln Gly Trp Arg Leu Arg His
                  85                  90                  95    
 Phe Val Ser Trp Leu Trp Tyr Glu Arg Glu Val Thr Leu Leu Glu Arg
             100                 105                 110        
 Trp Ile Gln Asp Leu Cys Thr Arg Val Val Leu Arg Ile Gly Ser Ala
         115                 120                 125            
 His Phe Tyr Ala Ile Val Val Ser Gln Gly Leu Leu Cys Pro Glu His
     130                 135                 140                
 Arg Leu
 145    



      <210> 752
      <211> 447
      <212> PRT
      <213> Homo sapiens


      <400> 752
 Met Met Gln Asp Tyr Val Arg Thr Gly Thr Tyr Gln Arg Ala Ile Leu
   1               5                  10                  15    
 Gln Asn His Thr Asp Phe Lys Asp Lys Ile Val Leu Asp Val Gly Cys
              20                  25                  30        
 Gly Ser Gly Ile Leu Ser Phe Phe Ala Ala Gln Ala Gly Ala Arg Lys
          35                  40                  45            
 Ile Tyr Ala Val Glu Ala Ser Thr Met Ala Gln His Ala Glu Val Leu
      50                  55                  60                
 Val Lys Ser Asn Asn Leu Thr Asp Arg Ile Val Val Ile Pro Gly Lys
  65                  70                  75                  80
 Val Glu Glu Val Ser Leu Pro Glu Gln Val Asp Ile Ile Ile Ser Glu
                  85                  90                  95    
 Pro Met Gly Tyr Met Leu Phe Asn Glu Arg Met Leu Glu Ser Tyr Leu
             100                 105                 110        
 His Ala Lys Lys Tyr Leu Lys Pro Ser Gly Asn Met Phe Pro Thr Ile
         115                 120                 125            
 Gly Asp Val His Leu Ala Pro Phe Thr Asp Glu Gln Leu Tyr Met Glu
     130                 135                 140                
 Gln Phe Thr Lys Ala Asn Phe Trp Tyr Gln Pro Ser Phe His Gly Val
 145                 150                 155                 160
 Asp Leu Ser Ala Leu Arg Gly Ala Ala Val Asp Glu Tyr Phe Arg Gln
                 165                 170                 175    
 Pro Val Val Asp Thr Phe Asp Ile Arg Ile Leu Met Ala Lys Ser Val
             180                 185                 190        
 Lys Tyr Thr Val Asn Phe Leu Glu Ala Lys Glu Gly Asp Leu His Arg
         195                 200                 205            
 Ile Glu Ile Pro Phe Lys Phe His Met Leu His Ser Gly Leu Val His
     210                 215                 220                
 Gly Leu Ala Phe Trp Phe Asp Val Ala Phe Ile Gly Ser Ile Met Thr
 225                 230                 235                 240
 Val Trp Leu Ser Thr Ala Pro Thr Glu Pro Leu Thr His Trp Tyr Gln
                 245                 250                 255    
 Val Arg Cys Leu Phe Gln Ser Pro Leu Phe Ala Lys Ala Gly Asp Thr
             260                 265                 270        
 Leu Ser Gly Thr Cys Leu Leu Ile Ala Asn Lys Arg Gln Ser Tyr Asp
         275                 280                 285            
 Ile Ser Ile Val Ala Gln Val Asp Gln Thr Gly Ser Lys Ser Ser Asn
     290                 295                 300                
 Leu Leu Asp Leu Lys Asn Pro Phe Phe Arg Tyr Thr Gly Thr Thr Pro
 305                 310                 315                 320
 Ser Pro Pro Pro Gly Ser His Tyr Thr Ser Pro Ser Glu Asn Met Trp
                 325                 330                 335    
 Asn Thr Gly Ser Thr Tyr Asn Leu Ser Ser Gly Met Ala Val Ala Gly
             340                 345                 350        
 Met Pro Thr Ala Tyr Asp Leu Ser Ser Val Ile Ala Ser Gly Ser Ser
         355                 360                 365            
 Val Gly His Asn Asn Leu Ile Pro Leu Ala Asn Thr Gly Ile Val Asn
     370                 375                 380                
 His Thr His Ser Arg Met Gly Ser Ile Met Ser Thr Gly Ile Val Gln
 385                 390                 395                 400
 Gly Ser Ser Gly Ala Gln Gly Ser Gly Gly Gly Ser Thr Ser Ala His
                 405                 410                 415    
 Tyr Ala Val Asn Ser Gln Phe Thr Met Gly Gly Pro Ala Ile Ser Met
             420                 425                 430        
 Ala Ser Pro Met Ser Ile Pro Thr Asn Thr Met His Tyr Gly Ser
         435                 440                 445        



      <210> 753
      <211> 462
      <212> PRT
      <213> Homo sapiens


      <400> 753
 Met Ser Leu Phe Gln Phe Tyr Gly Tyr Leu Ser Gln Gln Gln Asn Met
   1               5                  10                  15    
 Met Gln Asp Tyr Val Arg Thr Gly Thr Tyr Gln Arg Ala Ile Leu Gln
              20                  25                  30        
 Asn His Thr Asp Phe Lys Asp Lys Ile Val Leu Asp Val Gly Cys Gly
          35                  40                  45            
 Ser Gly Ile Leu Ser Phe Phe Ala Ala Gln Ala Gly Ala Arg Lys Ile
      50                  55                  60                
 Tyr Ala Val Glu Ala Ser Thr Met Ala Gln His Ala Glu Val Leu Val
  65                  70                  75                  80
 Lys Ser Asn Asn Leu Thr Asp Arg Ile Val Val Ile Pro Gly Lys Val
                  85                  90                  95    
 Glu Glu Val Ser Leu Pro Glu Gln Val Asp Ile Ile Ile Ser Glu Pro
             100                 105                 110        
 Met Gly Tyr Met Leu Phe Asn Glu Arg Met Leu Glu Ser Tyr Leu His
         115                 120                 125            
 Ala Lys Lys Tyr Leu Lys Pro Ser Gly Asn Met Phe Pro Thr Ile Gly
     130                 135                 140                
 Asp Val His Leu Ala Pro Phe Thr Asp Glu Gln Leu Tyr Met Glu Gln
 145                 150                 155                 160
 Phe Thr Lys Ala Asn Phe Trp Tyr Gln Pro Ser Phe His Gly Val Asp
                 165                 170                 175    
 Leu Ser Ala Leu Arg Gly Ala Ala Val Asp Glu Tyr Phe Arg Gln Pro
             180                 185                 190        
 Val Val Asp Thr Phe Asp Ile Arg Ile Leu Met Ala Lys Ser Val Lys
         195                 200                 205            
 Tyr Thr Val Asn Phe Leu Glu Ala Lys Glu Gly Asp Leu His Arg Ile
     210                 215                 220                
 Glu Ile Pro Phe Lys Phe His Met Leu His Ser Gly Leu Val His Gly
 225                 230                 235                 240
 Leu Ala Phe Trp Phe Asp Val Ala Phe Ile Gly Ser Ile Met Thr Val
                 245                 250                 255    
 Trp Leu Ser Thr Ala Pro Thr Glu Pro Leu Thr His Trp Tyr Gln Val
             260                 265                 270        
 Arg Cys Leu Phe Gln Ser Pro Leu Phe Ala Lys Ala Gly Asp Thr Leu
         275                 280                 285            
 Ser Gly Thr Cys Leu Leu Ile Ala Asn Lys Arg Gln Ser Tyr Asp Ile
     290                 295                 300                
 Ser Ile Val Ala Gln Val Asp Gln Thr Gly Ser Lys Ser Ser Asn Leu
 305                 310                 315                 320
 Leu Asp Leu Lys Asn Pro Phe Phe Arg Tyr Thr Gly Thr Thr Pro Ser
                 325                 330                 335    
 Pro Pro Pro Gly Ser His Tyr Thr Ser Pro Ser Glu Asn Met Trp Asn
             340                 345                 350        
 Thr Gly Ser Thr Tyr Asn Leu Ser Ser Gly Met Ala Val Ala Gly Met
         355                 360                 365            
 Pro Thr Ala Tyr Asp Leu Ser Ser Val Ile Ala Ser Gly Ser Ser Val
     370                 375                 380                
 Gly His Asn Asn Leu Ile Pro Leu Ala Asn Thr Gly Ile Val Asn His
 385                 390                 395                 400
 Thr His Ser Arg Met Gly Ser Ile Met Ser Thr Gly Ile Val Gln Gly
                 405                 410                 415    
 Ser Ser Gly Ala Gln Gly Ser Gly Gly Gly Ser Thr Ser Ala His Tyr
             420                 425                 430        
 Ala Val Asn Ser Gln Phe Thr Met Gly Gly Pro Ala Ile Ser Met Ala
         435                 440                 445            
 Ser Pro Met Ser Ile Pro Thr Asn Thr Met His Tyr Gly Ser
     450                 455                 460        



      <210> 754
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 754
 Met Pro Leu Ala Phe Leu Arg Pro Cys Glu Asn His Gly Thr Ala Leu
   1               5                  10                  15    
 Ser Leu Val Ser Ser Ala Phe Ser Phe Cys Asp Met Pro Ser Ser Gln
              20                  25                  30        
 Ile Asn Tyr Arg Tyr Leu Phe Arg Arg Glu Glu Asp Phe Thr Ser Gln
          35                  40                  45            
 Arg Val Arg Phe Glu Ile Tyr Thr Lys Lys Thr Thr Leu His Leu Met
      50                  55                  60                
 Leu His Leu Met Arg His Ser Phe Phe Tyr Lys Ser Ile Phe Leu Leu
  65                  70                  75                  80
 Ser Phe Arg Thr Leu Ile
                  85    



      <210> 755
      <211> 52
      <212> PRT
      <213> Homo sapiens


      <400> 755
 Met Asp Thr His Gly Val Val Leu Arg Ser Arg Glu Phe Ser Arg Gln
   1               5                  10                  15    
 Glu Arg Arg Gly Lys Lys Glu Ile Ser Ser Pro Val Gln Arg Gln Arg
              20                  25                  30        
 Glu Gly Ser Ser Lys Thr Lys Arg Gly Asn Pro Thr Cys His Gly Tyr
          35                  40                  45            
 Gln Ser Gly Ile
      50        



      <210> 756
      <211> 357
      <212> PRT
      <213> Homo sapiens


      <400> 756
 Met Arg Arg Thr Gly Pro Glu Glu Glu Ala Cys Gly Val Trp Leu Asp
   1               5                  10                  15    
 Ala Ala Ala Leu Lys Arg Arg Lys Val Gln Thr His Leu Ile Lys Pro
              20                  25                  30        
 Gly Thr Lys Met Leu Thr Leu Leu Pro Gly Glu Arg Lys Ala Asn Ile
          35                  40                  45            
 Tyr Phe Thr Gln Arg Arg Ala Pro Ser Thr Gly Ile His Gln Arg Ser
      50                  55                  60                
 Ile Ala Ser Phe Phe Thr Leu Gln Pro Gly Lys Thr Asn Gly Ser Asp
  65                  70                  75                  80
 Gln Lys Ser Val Ser Ser His Thr Glu Ser Gln Ile Asn Lys Glu Ser
                  85                  90                  95    
 Lys Lys Asn Ala Thr Gln Leu Asp His Leu Ile Pro Gly Leu Ala His
             100                 105                 110        
 Asp Cys Met Ala Ser Pro Leu Ala Thr Ser Thr Thr Ala Asp Ile Gln
         115                 120                 125            
 Glu Ala Gly Leu Ser Pro Gln Ser Leu Gln Thr Ser Gly His His Arg
     130                 135                 140                
 Met Lys Thr Pro Phe Ser Thr Glu Leu Ser Leu Leu Gln Pro Asp Thr
 145                 150                 155                 160
 Pro Asp Cys Ala Gly Asp Ser His Thr Pro Leu Ala Phe Ser Phe Thr
                 165                 170                 175    
 Glu Asp Leu Glu Ser Ser Cys Leu Leu Asp Arg Lys Glu Glu Lys Gly
             180                 185                 190        
 Asp Ser Ala Arg Lys Trp Glu Trp Leu His Glu Ser Lys Lys Asn Tyr
         195                 200                 205            
 Gln Ser Met Glu Lys His Thr Lys Leu Pro Gly Asp Lys Cys Cys Gln
     210                 215                 220                
 Pro Leu Gly Lys Thr Lys Leu Glu Arg Lys Val Ser Ala Lys Glu Asn
 225                 230                 235                 240
 Arg Gln Ala Pro Val Leu Leu Gln Thr Tyr Arg Glu Ser Trp Asn Gly
                 245                 250                 255    
 Glu Asn Ile Glu Ser Val Lys Gln Ser Arg Ser Pro Val Ser Val Phe
             260                 265                 270        
 Ser Trp Asp Asn Glu Lys Asn Asp Lys Asp Ser Trp Ser Gln Leu Phe
         275                 280                 285            
 Thr Glu Asp Ser Gln Gly Gln Arg Val Ile Ala His Asn Thr Arg Ala
     290                 295                 300                
 Pro Phe Gln Asp Val Thr Asn Asn Trp Asn Trp Asp Leu Gly Pro Phe
 305                 310                 315                 320
 Pro Asn Ser Pro Trp Ala Gln Cys Gln Glu Asp Gly Pro Thr Gln Asn
                 325                 330                 335    
 Leu Lys Pro Asp Leu Leu Phe Thr Gln Asp Ser Glu Gly Asn Gln Val
             340                 345                 350        
 Ile Arg His Gln Phe
         355        



      <210> 757
      <211> 597
      <212> PRT
      <213> Homo sapiens


      <400> 757
 Met Phe Pro Val Ala Pro Lys Pro Gln Asp Ser Ser Gln Pro Ser Asp
   1               5                  10                  15    
 Arg Leu Met Thr Glu Lys Gln Gln Glu Glu Ala Glu Trp Glu Ser Ile
              20                  25                  30        
 Asn Val Leu Leu Met Met His Gly Leu Lys Pro Leu Ser Leu Val Lys
          35                  40                  45            
 Arg Thr Asp Leu Lys Asp Leu Ile Ile Phe Asp Lys Gln Ser Ser Gln
      50                  55                  60                
 Arg Met Arg Gln Asn Leu Lys Leu Leu Val Glu Glu Thr Ser Cys Gln
  65                  70                  75                  80
 Gln Asn Met Ile Gln Glu Leu Ile Glu Thr Asn Gln Gln Leu Arg Asn
                  85                  90                  95    
 Glu Leu Gln Leu Glu Gln Ser Arg Ala Ala Asn Gln Glu Gln Arg Ala
             100                 105                 110        
 Asn Asp Leu Glu Gln Ile Met Glu Ser Val Lys Ser Lys Ile Gly Glu
         115                 120                 125            
 Leu Glu Asp Glu Ser Leu Ser Arg Ala Cys His Gln Gln Asn Lys Ile
     130                 135                 140                
 Lys Asp Leu Gln Lys Glu Gln Lys Thr Leu Gln Val Lys Cys Gln His
 145                 150                 155                 160
 Tyr Lys Lys Lys Arg Thr Glu Gln Glu Glu Thr Ile Ala Ser Leu Gln
                 165                 170                 175    
 Met Glu Val Cys Arg Leu Lys Lys Glu Glu Glu Asp Arg Ile Val Thr
             180                 185                 190        
 Gln Asn Arg Val Phe Ala Tyr Leu Cys Lys Arg Val Pro His Thr Val
         195                 200                 205            
 Leu Asp Arg Gln Leu Leu Cys Leu Ile Asp Tyr Tyr Glu Ser Lys Ile
     210                 215                 220                
 Arg Lys Ile His Thr Gln Arg Gln Tyr Lys Glu Asp Glu Ser Gln Ser
 225                 230                 235                 240
 Glu Glu Glu Asn Asp Tyr Arg Asn Leu Asp Ala Ser Pro Thr Tyr Lys
                 245                 250                 255    
 Gly Leu Leu Met Ser Leu Gln Asn Gln Leu Lys Glu Ser Lys Ser Lys
             260                 265                 270        
 Ile Asp Ala Leu Ser Ser Glu Lys Leu Asn Leu Gln Lys Asp Leu Glu
         275                 280                 285            
 Thr Arg Pro Thr Gln His Glu Leu Arg Leu Tyr Lys Gln Gln Val Lys
     290                 295                 300                
 Lys Leu Glu Lys Ala Leu Lys Lys Asn Val Lys Leu Gln Glu Leu Ile
 305                 310                 315                 320
 Asn His Lys Lys Ala Glu Asp Thr Glu Lys Lys Asp Glu Pro Ser Lys
                 325                 330                 335    
 Tyr Asn Gln Gln Gln Ala Leu Ile Asp Gln Arg Tyr Phe Gln Val Leu
             340                 345                 350        
 Cys Ser Ile Asn Ser Ile Ile His Asn Pro Arg Ala Pro Val Ile Ile
         355                 360                 365            
 Tyr Lys Gln Thr Lys Gly Gly Val Gln Asn Phe Asn Lys Asp Leu Val
     370                 375                 380                
 Gln Asp Cys Gly Phe Glu His Leu Val Pro Val Ile Glu Met Trp Ala
 385                 390                 395                 400
 Asp Gln Leu Thr Ser Leu Lys Asp Leu Tyr Lys Ser Leu Lys Thr Leu
                 405                 410                 415    
 Ser Ala Glu Leu Val Pro Trp Leu Asn Leu Lys Lys Gln Asp Glu Asn
             420                 425                 430        
 Glu Gly Ile Lys Val Glu Asp Leu Leu Phe Ile Val Asp Thr Met Leu
         435                 440                 445            
 Glu Glu Val Glu Asn Lys Glu Lys Asp Ser Asn Met Pro His Phe Gln
     450                 455                 460                
 Thr Leu Gln Ala Ile Val Ser His Phe Gln Lys Leu Phe Asp Val Pro
 465                 470                 475                 480
 Ser Leu Asn Gly Val Tyr Pro Arg Met Asn Glu Val Tyr Thr Arg Leu
                 485                 490                 495    
 Gly Glu Met Asn Asn Ala Val Arg Asn Leu Gln Glu Leu Leu Glu Leu
             500                 505                 510        
 Asp Ser Ser Ser Ser Leu Cys Val Leu Val Ser Thr Val Gly Lys Leu
         515                 520                 525            
 Cys Arg Leu Ile Asn Glu Asp Val Asn Glu Gln Val Met Gln Val Leu
     530                 535                 540                
 Gly Pro Glu Asp Leu Gln Ser Ile Ile Tyr Lys Leu Glu Glu His Glu
 545                 550                 555                 560
 Glu Phe Phe Pro Ala Phe Gln Ala Phe Thr Asn Asp Leu Leu Glu Ile
                 565                 570                 575    
 Leu Glu Ile Asp Asp Leu Asp Ala Ile Val Pro Ala Val Lys Lys Leu
             580                 585                 590        
 Lys Val Leu Ser Tyr
         595        



      <210> 758
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 758
 Met Ser Thr Arg Ser Leu Gln Ser Val Val Val Pro Arg Cys Arg Gly
   1               5                  10                  15    
 Thr Ala Glu Ala Leu Gln Ile Thr Val Gly His Ile Leu Gly Asp Ala
              20                  25                  30        
 Gly Ser Pro Tyr Leu Thr Gly Leu Ile Ser Ser Val Leu Arg Ala Arg
          35                  40                  45            
 Arg Pro Asp Ser Tyr Leu Gln Arg Phe Arg Ser Leu Gln Gln Ser Phe
      50                  55                  60                
 Leu Cys Cys Ala Phe Val Ile Ala Leu Gly Gly Gly Cys Phe Leu Leu
  65                  70                  75                  80
 Thr Ala Leu Tyr Leu Glu Arg Asp Glu Thr Arg Ala Trp Gln Pro Val
                  85                  90                  95    
 Thr Gly Thr Pro Asp Ser Asn Asp Val Asp Ser Asn Asp Leu Glu Arg
             100                 105                 110        
 Gln Gly Leu Leu Ser Gly Ala Gly Ala Ser Thr Glu Glu Pro
         115                 120                 125    



      <210> 759
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 759
 Met Arg Tyr Thr Thr Val Pro Ser Val Arg Pro Thr Ala Leu Ala Thr
   1               5                  10                  15    
 Lys Lys Leu Asp Leu Trp Arg Leu Pro Pro Phe Leu Ile Ile His Leu
              20                  25                  30        
 Lys Arg Phe Gln Phe Val Asn Asp Gln Trp Ile Lys Ser Gln Lys Ile
          35                  40                  45            
 Val Lys Phe Pro Arg Glu Ser Phe Asp Pro Ser Ala Phe Leu Val Pro
      50                  55                  60                
 Arg Asp Pro Ala Leu Cys Gln His Gln Pro Leu Thr Pro Gln Gly Asp
  65                  70                  75                  80
 Glu Leu Ser Lys Pro Arg Ile Leu Ala Arg Glu Val Lys Lys Val Asp
                  85                  90                  95    
 Val Gln Ser Leu Ala Gly Glu Glu Asp Met Leu Leu Ser Lys Ser Pro
             100                 105                 110        
 Ser Ser Leu Ser Ala Asn Ile Ser Ser Ser Pro Lys Gly Ser Pro Ser
         115                 120                 125            
 Ser Ser Arg Lys Ser Gly Thr Ser Cys Pro Ser Ser Lys Asn Ser Ser
     130                 135                 140                
 Pro Asn Ser Cys Pro Arg Thr Leu Gly Arg Ser Lys Gly Arg Leu Arg
 145                 150                 155                 160
 Leu Pro Gln Ile Gly Ser Lys Asn Lys Leu Ser Ser Ser Lys Lys Asn
                 165                 170                 175    
 Leu Asp Ala Ser Lys Glu Asn Gly Ala Gly Gln Ile Cys Glu Leu Ala
             180                 185                 190        
 Asp Ala Leu Ser
         195    



      <210> 760
      <211> 82
      <212> PRT
      <213> Homo sapiens


      <400> 760
 Met Leu Gly Ser Gln Thr Gly Pro Leu Pro Ser Pro Tyr Pro Glu His
   1               5                  10                  15    
 Pro Pro Leu Ser Pro Thr Thr Leu Cys Leu Gly Val Leu Cys Asp Phe
              20                  25                  30        
 Leu Gln Ser Thr Leu Ala Met Trp Arg Cys Tyr Leu Cys Leu Leu Ala
          35                  40                  45            
 Phe Cys Pro Leu Val Ser Leu Pro Ser His Trp Arg Val Asp Phe Pro
      50                  55                  60                
 Pro Ala Gly Pro His Leu Arg Phe Ser Leu Leu Thr Cys Cys Leu Ala
  65                  70                  75                  80
 Leu Gly
        



      <210> 761
      <211> 178
      <212> PRT
      <213> Homo sapiens


      <400> 761
 Met Ser Thr Pro Pro Leu Ala Ala Ser Gly Met Ala Pro Gly Pro Phe
   1               5                  10                  15    
 Ala Gly Pro Gln Ala Gln Gln Ala Ala Arg Glu Val Asn Thr Ala Ser
              20                  25                  30        
 Leu Cys Arg Ile Gly Gln Glu Thr Val Gln Asp Ile Val Tyr Arg Thr
          35                  40                  45            
 Met Glu Ile Phe Gln Leu Leu Arg Asn Met Gln Leu Pro Asn Gly Val
      50                  55                  60                
 Thr Tyr His Thr Gly Thr Tyr Gln Asp Arg Leu Thr Lys Leu Gln Asp
  65                  70                  75                  80
 Asn Leu Arg Gln Leu Ser Val Leu Phe Arg Lys Leu Arg Leu Val Tyr
                  85                  90                  95    
 Asp Lys Cys Asn Glu Asn Cys Gly Gly Met Asp Pro Ile Pro Val Glu
             100                 105                 110        
 Gln Leu Ile Pro Tyr Val Glu Glu Asp Gly Ser Lys Asn Asp Asp Arg
         115                 120                 125            
 Ala Gly Pro Pro Arg Phe Ala Ser Glu Glu Arg Arg Glu Ile Ala Glu
     130                 135                 140                
 Val Asn Lys Lys Leu Lys Gln Lys Asn Gln Gln Leu Lys Gln Ile Met
 145                 150                 155                 160
 Asp Gln Leu Arg Asn Leu Ile Trp Asp Ile Asn Ala Met Leu Ala Met
                 165                 170                 175    
 Arg Asn
        



      <210> 762
      <211> 592
      <212> PRT
      <213> Homo sapiens


      <400> 762
 Met Ala Ser Val Val Val Lys Thr Ile Trp Gln Ser Lys Glu Ile His
   1               5                  10                  15    
 Glu Ala Gly Asp Thr Pro Thr Gly Val Glu Ser Cys Ser Gln Leu Val
              20                  25                  30        
 Pro Glu Ala Pro Arg Arg Val Thr Ser Arg Ala Lys Gly Ile Pro Lys
          35                  40                  45            
 Lys Lys Lys Ala Val Ser Phe His Gly Val Glu Pro Gln Met Ser His
      50                  55                  60                
 Gln Pro Met His Trp Cys Leu Asn Leu Lys Arg Ser Ser Ala Cys Thr
  65                  70                  75                  80
 Asn Val Ser Leu Leu Asn Leu Ala Ala Met Glu Pro Thr Asp Ser Thr
                  85                  90                  95    
 Gly Thr Asp Ser Thr Val Glu Asp Leu Ser Gly Gln Leu Thr Leu Ala
             100                 105                 110        
 Gly Pro Pro Ala Ser Pro Thr Leu Pro Trp Asp Pro Asp Asp Ala Asp
         115                 120                 125            
 Ile Thr Glu Ile Leu Ser Gly Val Asn Ser Gly Leu Val Arg Ala Lys
     130                 135                 140                
 Asp Ser Ile Thr Ser Leu Lys Glu Lys Thr Asn Arg Val Asn Gln His
 145                 150                 155                 160
 Val Gln Ser Leu Gln Ser Glu Cys Ser Val Leu Ser Glu Asn Leu Glu
                 165                 170                 175    
 Arg Arg Arg Gln Glu Ala Glu Glu Leu Glu Gly Tyr Cys Ile Gln Leu
             180                 185                 190        
 Lys Glu Asn Cys Trp Lys Val Thr Arg Ser Val Glu Asp Ala Glu Ile
         195                 200                 205            
 Lys Thr Asn Val Leu Lys Gln Asn Ser Ala Leu Leu Glu Glu Lys Leu
     210                 215                 220                
 Arg Tyr Leu Gln Gln Gln Leu Gln Asp Glu Thr Pro Arg Arg Gln Glu
 225                 230                 235                 240
 Ala Glu Leu Gln Glu Pro Glu Glu Lys Gln Glu Pro Glu Glu Lys Gln
                 245                 250                 255    
 Glu Pro Glu Glu Lys Gln Lys Pro Glu Ala Gly Leu Ser Trp Asn Ser
             260                 265                 270        
 Leu Gly Pro Ala Ala Thr Ser Gln Gly Cys Pro Gly Pro Pro Gly Ser
         275                 280                 285            
 Pro Asp Lys Pro Ser Arg Pro His Gly Leu Val Pro Ala Gly Trp Gly
     290                 295                 300                
 Met Gly Pro Arg Ala Gly Glu Gly Pro Tyr Val Ser Glu Gln Glu Leu
 305                 310                 315                 320
 Gln Lys Leu Phe Thr Gly Ile Glu Glu Leu Arg Arg Glu Val Ser Ser
                 325                 330                 335    
 Leu Thr Ala Arg Trp His Gln Glu Glu Gly Ala Val Gln Glu Ala Leu
             340                 345                 350        
 Arg Leu Leu Gly Gly Leu Gly Gly Arg Val Asp Gly Phe Leu Gly Gln
         355                 360                 365            
 Trp Glu Arg Ala Gln Arg Glu Gln Ala Gln Thr Ala Arg Asp Leu Gln
     370                 375                 380                
 Glu Leu Arg Gly Arg Ala Asp Glu Leu Cys Thr Met Val Glu Arg Ser
 385                 390                 395                 400
 Ala Val Ser Val Ala Ser Leu Arg Ser Glu Leu Glu Gly Leu Gly Pro
                 405                 410                 415    
 Leu Lys Pro Ile Leu Glu Glu Phe Gly Arg Gln Phe Gln Asn Ser Arg
             420                 425                 430        
 Arg Gly Pro Asp Leu Ser Met Asn Leu Asp Arg Ser His Gln Gly Asn
         435                 440                 445            
 Cys Ala Arg Cys Ala Ser Gln Gly Ser Gln Leu Ser Thr Glu Ser Leu
     450                 455                 460                
 Gln Gln Leu Leu Asp Arg Ala Leu Thr Ser Leu Val Asp Glu Val Lys
 465                 470                 475                 480
 Gln Arg Gly Leu Thr Pro Ala Cys Pro Ser Cys Gln Arg Leu His Lys
                 485                 490                 495    
 Lys Ile Leu Glu Leu Glu Arg Gln Ala Leu Ala Lys His Val Arg Ala
             500                 505                 510        
 Glu Ala Leu Ser Ser Thr Leu Arg Leu Ala Gln Asp Glu Ala Leu Arg
         515                 520                 525            
 Ala Lys Asn Leu Leu Leu Thr Asp Lys Met Lys Pro Glu Glu Lys Met
     530                 535                 540                
 Ala Thr Leu Asp His Leu His Leu Lys Met Cys Ser Leu His Asp His
 545                 550                 555                 560
 Leu Ser Asn Leu Pro Leu Glu Gly Ser Thr Gly Thr Met Gly Gly Gly
                 565                 570                 575    
 Ser Ser Ala Gly Thr Pro Pro Lys Gln Gly Gly Ser Ala Pro Glu Gln
             580                 585                 590        





      <210> 763
      <211> 449
      <212> PRT
      <213> Homo sapiens


      <400> 763
 Met Asp Arg Val Tyr Glu Ile Pro Glu Glu Pro Asn Val Asp Pro Val
   1               5                  10                  15    
 Ser Ser Leu Glu Glu Asp Val Ile Arg Gly Ala Asn Pro Arg Phe Thr
              20                  25                  30        
 Phe Pro Phe Ser Ile Leu Phe Ser Thr Phe Leu Tyr Cys Gly Glu Ala
          35                  40                  45            
 Ala Ser Ala Leu Tyr Met Val Arg Ile Tyr Arg Lys Asn Ser Glu Thr
      50                  55                  60                
 Tyr Trp Met Thr Tyr Thr Phe Ser Phe Phe Met Phe Ser Ser Ile Met
  65                  70                  75                  80
 Val Gln Leu Thr Leu Ile Phe Val His Arg Asp Leu Ala Lys Asp Lys
                  85                  90                  95    
 Pro Leu Ser Leu Phe Met His Leu Ile Leu Leu Gly Pro Val Ile Arg
             100                 105                 110        
 Cys Leu Glu Ala Met Ile Lys Tyr Leu Thr Leu Trp Lys Lys Glu Glu
         115                 120                 125            
 Gln Glu Glu Pro Tyr Val Ser Leu Thr Arg Lys Lys Met Leu Ile Asp
     130                 135                 140                
 Gly Glu Glu Val Leu Ile Glu Trp Glu Val Gly His Ser Ile Arg Thr
 145                 150                 155                 160
 Leu Ala Met His Arg Asn Ala Tyr Lys Arg Met Ser Gln Ile Gln Ala
                 165                 170                 175    
 Phe Leu Gly Ser Val Pro Gln Leu Thr Tyr Gln Leu Tyr Val Ser Leu
             180                 185                 190        
 Ile Ser Ala Glu Val Pro Leu Gly Arg Val Val Leu Met Val Phe Ser
         195                 200                 205            
 Leu Val Ser Val Thr Tyr Gly Ala Thr Leu Cys Asn Met Leu Ala Ile
     210                 215                 220                
 Gln Ile Lys Tyr Asp Asp Tyr Lys Ile Arg Leu Gly Pro Leu Glu Val
 225                 230                 235                 240
 Leu Cys Ile Thr Ile Trp Arg Thr Leu Glu Ile Thr Ser Arg Leu Leu
                 245                 250                 255    
 Ile Leu Val Leu Phe Ser Ala Thr Leu Lys Leu Lys Ala Val Pro Phe
             260                 265                 270        
 Leu Val Leu Asn Phe Leu Ile Ile Leu Phe Glu Pro Trp Ile Lys Phe
         275                 280                 285            
 Trp Arg Ser Gly Ala Gln Met Pro Asn Asn Ile Glu Lys Asn Phe Ser
     290                 295                 300                
 Arg Val Gly Thr Leu Val Val Leu Ile Ser Val Thr Ile Leu Tyr Ala
 305                 310                 315                 320
 Gly Ile Asn Phe Ser Cys Trp Ser Ala Leu Gln Leu Arg Leu Ala Asp
                 325                 330                 335    
 Arg Asp Leu Val Asp Lys Gly Gln Asn Trp Gly His Met Gly Leu His
             340                 345                 350        
 Tyr Ser Val Arg Leu Val Glu Asn Val Ile Met Val Leu Val Phe Lys
         355                 360                 365            
 Phe Phe Gly Val Lys Val Leu Leu Asn Tyr Cys His Ser Leu Ile Ala
     370                 375                 380                
 Leu Gln Leu Ile Ile Ala Tyr Leu Ile Ser Ile Gly Phe Met Leu Leu
 385                 390                 395                 400
 Phe Phe Gln Tyr Leu His Pro Leu Arg Ser Leu Phe Thr His Asn Val
                 405                 410                 415    
 Val Asp Tyr Leu His Cys Val Cys Cys His Gln His Pro Arg Thr Arg
             420                 425                 430        
 Val Glu Asn Ser Glu Pro Pro Phe Glu Thr Glu Ala Arg Gln Ser Val
         435                 440                 445            
 Val
    



      <210> 764
      <211> 1148
      <212> PRT
      <213> Homo sapiens


      <400> 764
 Met Pro Leu Phe Lys Asn Thr Ser Val Ser Ser Leu Tyr Ser Gly Cys
   1               5                  10                  15    
 Arg Leu Thr Leu Leu Arg Pro Glu Lys Asp Gly Ala Ala Thr Arg Val
              20                  25                  30        
 Asp Ala Val Cys Thr His Arg Pro Asp Pro Lys Ser Pro Gly Leu Asp
          35                  40                  45            
 Arg Glu Arg Leu Tyr Trp Lys Leu Ser Gln Leu Thr His Gly Ile Thr
      50                  55                  60                
 Glu Leu Gly Pro Tyr Thr Leu Asp Arg His Ser Leu Tyr Val Asn Gly
  65                  70                  75                  80
 Phe Thr His Gln Ser Ser Met Thr Thr Thr Arg Thr Pro Asp Thr Ser
                  85                  90                  95    
 Thr Met His Leu Ala Thr Ser Arg Thr Pro Ala Ser Leu Ser Gly Pro
             100                 105                 110        
 Thr Thr Ala Ser Pro Leu Leu Val Leu Phe Thr Ile Asn Phe Thr Ile
         115                 120                 125            
 Thr Asn Leu Arg Tyr Glu Glu Asn Met His His Pro Gly Ser Arg Lys
     130                 135                 140                
 Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Arg Pro Val Phe
 145                 150                 155                 160
 Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu
                 165                 170                 175    
 Leu Arg Pro Lys Lys Asp Gly Ala Ala Thr Lys Val Asp Ala Ile Cys
             180                 185                 190        
 Thr Tyr Arg Pro Asp Pro Lys Ser Pro Gly Leu Asp Arg Glu Gln Leu
         195                 200                 205            
 Tyr Trp Glu Leu Ser Gln Leu Thr His Ser Ile Thr Glu Leu Gly Pro
     210                 215                 220                
 Tyr Thr Leu Asp Arg Asp Ser Leu Tyr Val Asn Gly Phe Thr Gln Arg
 225                 230                 235                 240
 Ser Ser Val Pro Thr Thr Ser Ile Pro Gly Thr Pro Thr Val Asp Leu
                 245                 250                 255    
 Gly Thr Ser Gly Thr Pro Val Ser Lys Pro Gly Pro Ser Ala Ala Ser
             260                 265                 270        
 Pro Leu Leu Val Leu Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Arg
         275                 280                 285            
 Tyr Glu Glu Asn Met Gln His Pro Gly Ser Arg Lys Phe Asn Thr Thr
     290                 295                 300                
 Glu Arg Val Leu Gln Gly Leu Leu Arg Ser Leu Phe Lys Ser Thr Ser
 305                 310                 315                 320
 Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu
                 325                 330                 335    
 Lys Asp Gly Thr Ala Thr Gly Val Asp Ala Ile Cys Thr His His Pro
             340                 345                 350        
 Asp Pro Lys Ser Pro Arg Leu Asp Arg Glu Gln Leu Tyr Trp Glu Leu
         355                 360                 365            
 Ser Gln Leu Thr His Asn Ile Thr Glu Leu Gly Pro Tyr Ala Leu Asp
     370                 375                 380                
 Asn Asp Ser Leu Phe Val Asn Gly Phe Thr His Arg Ser Ser Val Ser
 385                 390                 395                 400
 Thr Thr Ser Thr Pro Gly Thr Pro Thr Val Tyr Leu Gly Ala Ser Lys
                 405                 410                 415    
 Thr Pro Ala Ser Ile Phe Gly Pro Ser Ala Ala Ser His Leu Leu Ile
             420                 425                 430        
 Leu Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Arg Tyr Glu Glu Asn
         435                 440                 445            
 Met Trp Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln
     450                 455                 460                
 Gly Leu Leu Arg Pro Leu Phe Lys Asn Thr Ser Val Gly Pro Leu Tyr
 465                 470                 475                 480
 Ser Gly Ser Arg Leu Thr Leu Leu Arg Pro Glu Lys Asp Gly Glu Ala
                 485                 490                 495    
 Thr Gly Val Asp Ala Ile Cys Thr His Arg Pro Asp Pro Thr Gly Pro
             500                 505                 510        
 Gly Leu Asp Arg Glu Gln Leu Tyr Leu Glu Leu Ser Gln Leu Thr His
         515                 520                 525            
 Ser Ile Thr Glu Leu Gly Pro Tyr Thr Leu Asp Arg Asp Ser Leu Tyr
     530                 535                 540                
 Val Asn Gly Phe Thr His Arg Ser Ser Val Pro Thr Thr Ser Thr Gly
 545                 550                 555                 560
 Val Val Ser Glu Glu Pro Phe Thr Leu Asn Phe Thr Ile Asn Asn Leu
                 565                 570                 575    
 Arg Tyr Met Ala Asp Met Gly Gln Pro Gly Ser Leu Lys Phe Asn Ile
             580                 585                 590        
 Thr Asp Asn Val Met Lys His Leu Leu Ser Pro Leu Phe Gln Arg Ser
         595                 600                 605            
 Ser Leu Gly Ala Arg Tyr Thr Gly Cys Arg Val Ile Ala Leu Arg Ser
     610                 615                 620                
 Val Lys Asn Gly Ser Glu Thr Arg Val Asp Leu Leu Cys Thr Tyr Leu
 625                 630                 635                 640
 Gln Pro Leu Ser Gly Pro Gly Leu Pro Ile Lys Gln Val Phe His Glu
                 645                 650                 655    
 Leu Ser Gln Gln Thr His Gly Ile Thr Arg Leu Gly Pro Tyr Ser Leu
             660                 665                 670        
 Asp Lys Asp Ser Leu Tyr Leu Asn Gly Tyr Asn Glu Pro Gly Leu Asp
         675                 680                 685            
 Glu Pro Pro Thr Thr Pro Lys Pro Ala Thr Thr Phe Leu Pro Pro Leu
     690                 695                 700                
 Ser Glu Ala Thr Thr Ala Met Gly Tyr His Leu Lys Thr Leu Thr Leu
 705                 710                 715                 720
 Asn Phe Thr Ile Ser Asn Leu Gln Tyr Ser Pro Asp Met Gly Lys Gly
                 725                 730                 735    
 Ser Ala Thr Phe Asn Ser Thr Glu Gly Val Leu Gln His Leu Leu Arg
             740                 745                 750        
 Pro Leu Phe Gln Lys Ser Ser Met Gly Pro Phe Tyr Leu Gly Cys Gln
         755                 760                 765            
 Leu Ile Ser Leu Arg Pro Glu Lys Asp Gly Ala Ala Thr Gly Val Asp
     770                 775                 780                
 Thr Thr Cys Thr Tyr His Pro Asp Pro Val Gly Pro Gly Leu Asp Ile
 785                 790                 795                 800
 Gln Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His Gly Val Thr Gln
                 805                 810                 815    
 Leu Gly Phe Tyr Val Leu Asp Arg Asp Ser Leu Phe Ile Asn Gly Tyr
             820                 825                 830        
 Ala Pro Gln Asn Leu Ser Ile Arg Gly Glu Tyr Gln Ile Asn Phe His
         835                 840                 845            
 Ile Val Asn Trp Asn Leu Ser Asn Pro Asp Pro Thr Ser Ser Glu Tyr
     850                 855                 860                
 Ile Thr Leu Leu Arg Asp Ile Gln Asp Lys Val Thr Thr Leu Tyr Lys
 865                 870                 875                 880
 Gly Ser Gln Leu His Asp Thr Phe Arg Phe Cys Leu Val Thr Asn Leu
                 885                 890                 895    
 Thr Met Asp Ser Val Leu Val Thr Val Lys Ala Leu Phe Ser Ser Asn
             900                 905                 910        
 Leu Asp Pro Ser Leu Val Glu Gln Val Phe Leu Asp Lys Thr Leu Asn
         915                 920                 925            
 Ala Ser Phe His Trp Leu Gly Ser Thr Tyr Gln Leu Val Asp Ile His
     930                 935                 940                
 Val Thr Glu Met Glu Ser Ser Val Tyr Gln Pro Thr Ser Ser Ser Ser
 945                 950                 955                 960
 Thr Gln His Phe Tyr Leu Asn Phe Thr Ile Thr Asn Leu Pro Tyr Ser
                 965                 970                 975    
 Gln Asp Lys Ala Gln Pro Gly Thr Thr Asn Tyr Gln Arg Asn Lys Arg
             980                 985                 990        
 Asn Ile Glu Asp Ala Leu Asn Gln Leu Phe Arg Asn Ser Ser Ile Lys
         995                1000                1005            
 Ser Tyr Phe Ser Asp Cys Gln Val Ser Thr Phe Arg Ser Val Pro Asn
    1010                1015                1020                
 Arg His His Thr Gly Val Asp Ser Leu Cys Asn Phe Ser Pro Leu Ala
1025                1030                1035                1040
 Arg Arg Val Asp Arg Val Ala Ile Tyr Glu Glu Phe Leu Arg Met Thr
                1045                1050                1055    
 Arg Asn Gly Thr Gln Leu Gln Asn Phe Thr Leu Asp Arg Ser Ser Val
            1060                1065                1070        
 Leu Val Asp Gly Tyr Ser Pro Asn Arg Asn Glu Pro Leu Thr Gly Asn
        1075                1080                1085            
 Ser Asp Leu Pro Phe Trp Ala Val Ile Leu Ile Gly Leu Ala Gly Leu
    1090                1095                1100                
 Leu Gly Leu Ile Thr Cys Leu Ile Cys Gly Val Leu Val Thr Thr Arg
1105                1110                1115                1120
 Arg Arg Lys Lys Glu Gly Glu Tyr Asn Val Gln Gln Gln Cys Pro Gly
                1125                1130                1135    
 Tyr Tyr Gln Ser His Leu Asp Leu Glu Asp Leu Gln
            1140                1145            



      <210> 765
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 765
 Met Met Lys Cys Arg Asp His Gln Pro Leu Gly Val Asp Pro Ser Pro
   1               5                  10                  15    
 Pro Arg Arg Ser Leu Gly Trp Lys Arg Lys Arg Glu Cys Leu Asp Glu
              20                  25                  30        
 Ser Asp Asp Glu Pro Glu Lys Glu Leu Ala Pro Glu Pro Glu Glu Thr
          35                  40                  45            
 Trp Val Ala Glu Thr Leu Cys Gly Leu Lys Met Lys Ala Lys Arg Arg
      50                  55                  60                
 Arg Val Ser Leu Val Leu Pro Glu Tyr Tyr Glu Ala Phe Asn Arg Leu
  65                  70                  75                  80
 Leu Gly Arg Arg Thr Pro Gln Arg Ala Pro Pro Ile Leu Phe Phe Leu
                  85                  90                  95    
 Lys Arg Lys Leu Pro Ile Thr Thr Leu Phe Gln Trp Glu Lys Tyr Ala
             100                 105                 110        
 Pro Val Gly Glu Leu Ser Met Arg Glu Asp Ser Glu Val Ile Thr His
         115                 120                 125            
 Glu Gly His Leu Gly Asp Asn Arg Gly Leu Gly Arg Leu Asp Lys Gly
     130                 135                 140                
 Lys Pro Cys Pro Ala Ser His Thr Asp Ile Cys Ser Leu Ile Thr Glu
 145                 150                 155                 160
 Asp Pro Val Ile Lys Arg Phe Leu Ala Trp Asp Lys Asp Leu Arg Val
                 165                 170                 175    
 Ser Asp Lys Val Arg Met Ile Ser Met
             180                 185



      <210> 766
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 766
 Met Val Gly Pro Ser Ser Cys Ser Val Pro Leu Asn Lys Pro Gly Gly
   1               5                  10                  15    
 Met Glu Gly Pro Arg Ala Pro Pro Pro Tyr Gln Ala Gln Ala Leu Gln
              20                  25                  30        
 Gly Glu Pro Ala Glu Thr Pro Glu Pro Val Leu Asp Pro Gly Pro Leu
          35                  40                  45            
 Thr Leu Pro Thr Pro Ser Ser Val Pro Gly Arg Gly Leu Gly Gln Ser
      50                  55                  60                
 Ser Trp Ser Ser Ala Gly Arg Pro Ser Ser Pro Ser Ser Gly Arg His
  65                  70                  75                  80
 Ser Pro Leu Ser Gly Arg Arg Pro Arg Val Leu Ser Arg Gly Gly Cys
                  85                  90                  95    
 Ser Glu Ser Ile His Pro Ser Asp Gly Lys Ser His Arg Val Gln Pro
             100                 105                 110        
 Thr
    



      <210> 767
      <211> 297
      <212> PRT
      <213> Homo sapiens


      <400> 767
 Met Gly Asn Leu His Asp Arg Tyr Asn Arg Leu Glu Arg Leu Arg Ser
   1               5                  10                  15    
 Leu Leu Pro His Thr Ala His Glu Pro Phe Pro Leu His Ser Tyr Lys
              20                  25                  30        
 Glu Ile Lys Val Ile Gln Ala Asn Asn Asp Ile Pro Val Glu Glu Ile
          35                  40                  45            
 His Ser Pro Phe Thr Thr Ile Leu Leu Arg Thr Phe Leu Asn Tyr Leu
      50                  55                  60                
 Leu His Leu Ala Tyr His Ile Tyr His Glu Glu Phe Gln Lys Arg Ser
  65                  70                  75                  80
 Pro Ser Leu Phe Leu Cys Phe Thr Lys Leu Met Thr Glu Asn Ile Arg
                  85                  90                  95    
 Pro Asn Ala Cys Gln Ile Lys Gly Asn Leu Phe Arg Glu Gln Gln Arg
             100                 105                 110        
 Thr Leu Tyr Ser Met Ser Tyr Met Asn Lys Cys Trp Glu Ile Tyr Leu
         115                 120                 125            
 Ala Tyr Cys Arg Pro Ser Ala Ala Pro Pro His Glu Pro Thr Met Lys
     130                 135                 140                
 Met Arg His Phe Leu Trp Met Leu Lys Asp Phe Lys Met Ile Asn Lys
 145                 150                 155                 160
 Glu Leu Thr Ala Ala Thr Phe Met Glu Val Ile Ala Glu Asp Asn Arg
                 165                 170                 175    
 Phe Ile Tyr Asp Gly Ile Asp Ser Asn Phe Glu Pro Glu Leu Val Phe
             180                 185                 190        
 Leu Glu Phe Phe Glu Ala Leu Leu Ser Phe Ala Phe Ile Cys Val Thr
         195                 200                 205            
 Asp Gln Met Thr Lys Ser Tyr Thr Asn Val Pro Ala Asp Asp Val Ser
     210                 215                 220                
 Gly Asn Lys His Glu Thr Ile Tyr Thr Ile Leu Asn Gln Asp Ala Gln
 225                 230                 235                 240
 Asn Lys Ser Pro Ser Ala Val Met Ser His Glu Ser Asp Ala Ala His
                 245                 250                 255    
 Ser Asp Ser Ala Arg Ser Ser Ser Ser Lys Leu Glu Leu Ser Pro Asp
             260                 265                 270        
 Val Asn Lys Ile Arg Lys Ser Glu Pro Lys Ile Lys Lys Ser Val Ser
         275                 280                 285            
 His Glu Arg Val Ser Lys Met Asn Phe
     290                 295        



      <210> 768
      <211> 52
      <212> PRT
      <213> Homo sapiens


      <400> 768
 Met Asp Leu Glu Ala Ala Lys Asn Gly Thr Ala Trp Arg Pro Thr Ser
   1               5                  10                  15    
 Ala Glu Gly Asp Phe Glu Leu Gly Ile Ser Arg Tyr Ile Pro Ser Ser
              20                  25                  30        
 His Trp Leu Phe Arg Tyr Thr Pro Ile Ser Arg Thr Lys Phe Thr Leu
          35                  40                  45            
 Gly Lys Lys Leu
      50        



      <210> 769
      <211> 347
      <212> PRT
      <213> Homo sapiens


      <400> 769
 Met Asn Thr Leu Met Asp Val Leu Arg His Arg Pro Gly Trp Val Glu
   1               5                  10                  15    
 Val Lys Asp Glu Gly Glu Trp Asp Phe Tyr Trp Arg Asp Val Ser Trp
              20                  25                  30        
 Leu Arg Glu Asn Phe Asp His Thr Tyr Met Asp Glu His Val Arg Ile
          35                  40                  45            
 Ser His Phe Arg Asn His Tyr Glu Leu Thr Arg Lys Asn Tyr Met Val
      50                  55                  60                
 Lys Asn Leu Lys Arg Phe Arg Lys Gln Leu Glu Arg Glu Ala Gly Lys
  65                  70                  75                  80
 Leu Glu Ala Ala Lys Cys Asp Phe Phe Pro Lys Thr Phe Glu Met Pro
                  85                  90                  95    
 Cys Glu Tyr His Leu Phe Val Glu Glu Phe Arg Lys Asn Pro Gly Ile
             100                 105                 110        
 Thr Trp Ile Met Lys Pro Val Ala Arg Ser Gln Gly Lys Gly Ile Phe
         115                 120                 125            
 Leu Phe Cys Arg Leu Lys Asp Ile Val Asp Trp Arg Lys Asp Thr Arg
     130                 135                 140                
 Ser Ser Asp Asp Gln Lys Asp Asp Ile Pro Val Glu Asn Tyr Val Ala
 145                 150                 155                 160
 Gln Arg Tyr Ile Glu Asn Pro Tyr Leu Ile Gly Gly Arg Lys Phe Asp
                 165                 170                 175    
 Leu Arg Val Tyr Val Leu Val Met Ser Tyr Ile Pro Leu Arg Ala Trp
             180                 185                 190        
 Leu Tyr Arg Asp Gly Phe Ala Arg Phe Ser Asn Thr Arg Phe Thr Leu
         195                 200                 205            
 Asn Ser Ile Asp Asp Gln Tyr Val His Pro Thr Asn Val Ala Val Gln
     210                 215                 220                
 Lys Thr Ser Pro Asp Tyr His Pro Lys Lys Gly Cys Lys Trp Thr Leu
 225                 230                 235                 240
 Gln Arg Phe Arg Gln Tyr Leu Ala Ser Lys His Gly Pro Glu Ala Val
                 245                 250                 255    
 Glu Thr Leu Phe Arg Asp Ile Asp Asn Ile Phe Val Lys Ser Leu Gln
             260                 265                 270        
 Ser Val Gln Lys Val Ile Ile Ser Asp Lys His Cys Phe Glu Leu Tyr
         275                 280                 285            
 Gly Tyr Asp Ile Leu Ile Asp Gln Asp Leu Lys Pro Trp Leu Leu Glu
     290                 295                 300                
 Val Asn Ala Ser Pro Ser Leu Thr Ala Ser Ser Gln Glu Asp Tyr Glu
 305                 310                 315                 320
 Leu Lys Thr Cys Leu Leu Glu Asp Thr Leu His Val Val Asp Met Glu
                 325                 330                 335    
 Ala Ser Phe Ser Pro Ile Ile Pro Ala Glu Val
             340                 345        



      <210> 770
      <211> 240
      <212> PRT
      <213> Homo sapiens


      <400> 770
 Met Pro Pro Leu Leu Phe Glu Val Ser Ser Leu Glu Asn Ala Phe Gln
   1               5                  10                  15    
 Ile Gly Gly His Pro Trp His Tyr Ile Val Thr Pro Asn Lys Lys Lys
              20                  25                  30        
 Gln Lys Gly Val Phe His Ile Cys Ala Leu Lys Asp Asn Ser Leu Ala
          35                  40                  45            
 Lys Asn Gly Ile Gln Glu Met Asp Cys Cys Ser Leu Glu Ser Asp Trp
      50                  55                  60                
 Ile Tyr Phe His Pro Asp Ala Ser Gly Arg Ile Ile His Val Gly Pro
  65                  70                  75                  80
 Asn Gln Val Lys Val Leu Lys Leu Thr Glu Ile Glu Asn Asn Ser Ser
                  85                  90                  95    
 Gln His Gln Ile Ser Glu Asp Phe Val Ile Leu Ala Asn Arg Glu Asn
             100                 105                 110        
 His Lys Asn Glu Asn Val Leu Thr Val Thr Ala Ser Gly Arg Val Val
         115                 120                 125            
 Lys Lys Ser Phe Asn Leu Leu Asp Asp Asp Pro Glu Gln Glu Thr Phe
     130                 135                 140                
 Lys Ile Val Asp Tyr Glu Asp Glu Leu Asp Leu Leu Ser Val Val Ala
 145                 150                 155                 160
 Val Thr Gln Ile Asp Ala Glu Gly Lys Ala His Leu Asp Phe His Cys
                 165                 170                 175    
 Asn Glu Tyr Gly Thr Leu Leu Lys Ser Ile Pro Leu Val Glu Ser Trp
             180                 185                 190        
 Asp Val Thr Tyr Ser His Glu Val Tyr Phe Asp Arg Asp Leu Val Leu
         195                 200                 205            
 His Ile Glu Gln Lys Pro Asn Arg Val Phe Ser Cys Tyr Val Tyr His
     210                 215                 220                
 Met Ile Cys Asp Thr Gly Glu Glu Glu Glu Thr Ile Asn Arg Ser Cys
 225                 230                 235                 240





      <210> 771
      <211> 189
      <212> PRT
      <213> Homo sapiens


      <400> 771
 Met Tyr Gly Asn Arg Ser Lys Gln His Glu Ser Cys Phe Val Phe Glu
   1               5                  10                  15    
 Gln Thr Thr Gly Leu Val Gly Leu Ala Val Cys Asn Thr Pro His Glu
              20                  25                  30        
 Val Cys Thr Phe Val Leu Ser Ser Phe Leu Asn Ser Gln Gly Arg Leu
          35                  40                  45            
 Asn Ser Cys His Phe Ala Tyr Cys Arg Val Asn Gly Ile Gln Met Phe
      50                  55                  60                
 Gln Ala Leu Asn Tyr Lys Pro Arg Glu Leu Leu Arg His Gly Arg Cys
  65                  70                  75                  80
 Pro Pro Thr Ser Leu Ile Arg Cys His Ile Phe Ile Tyr Phe Cys His
                  85                  90                  95    
 Asp Leu Phe Ile Lys Pro Val Phe Leu Leu Thr Phe Ser Leu Thr Phe
             100                 105                 110        
 Ser Trp Leu His Leu Cys Leu Leu Leu Ser Ala Pro Ser Gln Ile Tyr
         115                 120                 125            
 Ile Ser Val Phe His Leu Phe Ser Leu Pro Tyr Arg Phe Cys Leu Gly
     130                 135                 140                
 Ala Leu Asp Tyr Ile Tyr Leu Gly Leu Leu Lys Val Leu Pro Pro Phe
 145                 150                 155                 160
 Pro Ser Val Arg Ser Phe Pro Ser Val Phe Thr Asn Val Phe Ile Lys
                 165                 170                 175    
 Lys Thr His Lys Ile Phe Leu Phe Phe Leu Ser Leu Leu
             180                 185                



      <210> 772
      <211> 150
      <212> PRT
      <213> Homo sapiens


      <400> 772
 Met Trp Ser Pro Ala Pro Lys Ala Ser Phe Trp Ser Pro Leu Ser Thr
   1               5                  10                  15    
 Arg Ser Gly Gly Thr His Ala Cys Ser Ala Ser Met Arg Gln Pro Cys
              20                  25                  30        
 Ala Ser Pro Trp Ser Gln Gly Asn Ile Ser Ser Thr Arg Pro Ser Leu
          35                  40                  45            
 Leu Arg Cys Ala Asn Ser Leu Pro Ser Thr Lys Asp Lys Ala Lys Gly
      50                  55                  60                
 Pro Leu Leu Ala Gly His Pro Cys Pro Ile Phe Ser Pro Gly Pro Phe
  65                  70                  75                  80
 Pro Cys Gly His Arg Glu Val Trp Pro Glu Tyr Pro Thr Pro Ala Pro
                  85                  90                  95    
 Leu His Pro Glu Leu Gly Ala Thr Ser Glu Val Ser Ser Leu Ser Glu
             100                 105                 110        
 His Ala Phe Pro Cys Ser Ser Arg Gly Leu Ser Arg Leu Ser Asp Ala
         115                 120                 125            
 Gly Ala Glu Arg Pro Gly Arg Lys Gly Val Gln Pro Val Val Cys Lys
     130                 135                 140                
 Ala Leu Val Gly Thr Cys
 145                 150



      <210> 773
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 773
 Met Ala Glu Ala Ser Ser Ala Asn Leu Gly Ser Gly Cys Glu Glu Lys
   1               5                  10                  15    
 Arg His Glu Gly Ser Ser Ser Glu Ser Val Pro Pro Gly Thr Thr Ile
              20                  25                  30        
 Ser Arg Val Lys Leu Leu Asp Thr Met Val Asp Thr Phe Leu Gln Lys
          35                  40                  45            
 Leu Val Ala Ala Gly Ser Tyr Gln Arg Phe Thr Asp Cys Tyr Lys Cys
      50                  55                  60                
 Phe Tyr Gln Leu Gln Pro Ala Met Thr Gln Gln Ile Tyr Asp Lys Phe
  65                  70                  75                  80
 Ile Ala Gln Leu Gln Thr Ser Ile Arg Glu Glu Ile Ser Asp Ile Lys
                  85                  90                  95    
 Glu Glu Gly Asn Leu Glu Ala Val Leu Asn Ala Leu Asp Lys Ile Val
             100                 105                 110        
 Glu Glu Gly Lys Val Arg Lys Glu Pro Ala Trp Arg Pro Ser Gly Ile
         115                 120                 125            
 Pro Glu Lys Asp Leu His Ser Val Met Ala Pro Tyr Phe Leu Gln Gln
     130                 135                 140                
 Arg Asp Thr Leu Arg Arg His Val Gln Lys Gln Glu Ala Glu Asn Gln
 145                 150                 155                 160
 Gln Leu Ala Asp Ala Val Leu Ala Gly Arg Arg Gln Val Glu Glu Leu
                 165                 170                 175    
 Gln Leu Gln Val Gln Ala Gln Gln Gln Ala Trp Gln Ala Leu His Arg
             180                 185                 190        
 Glu Gln Arg Glu Leu Val Ala Val Leu Arg Glu Pro Glu
         195                 200                 205



      <210> 774
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 774
 Met Gly Val Ser Arg Ser Ala Arg Ala Pro Pro Asp Gly Glu Leu Ala
   1               5                  10                  15    
 Gly Gly Gly Gly Ser Ser Ser Ser Ser Leu Gly Gly Thr Ser Leu Ser
              20                  25                  30        
 Gln Leu Arg Gln Gly Lys Arg Glu Leu Arg Thr Leu Thr Pro Thr His
          35                  40                  45            
 Ala His Thr Gln Gly Ser Val Gly Trp Glu Arg Glu Gly Arg Phe Ser
      50                  55                  60                
 Phe Cys Ser Leu Gly Leu Pro Arg Ala Phe Pro Ala Ala Glu Arg Asp
  65                  70                  75                  80
 Thr Ser Ser Gln Val Lys Gly His Ser Gly Pro Gly Pro Asp Pro Val
                  85                  90                  95    
 Val Thr His Leu Gly Thr Phe Pro Asp Gln Leu Arg Leu Pro Cys Pro
             100                 105                 110        
 Pro Leu Ser Arg Lys Glu Pro Glu Pro Ser Pro Leu Ser His Pro Pro
         115                 120                 125            
 Gln Gly
     130



      <210> 775
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 775
 Met Val Ala Ala Asn Thr Arg Ala Pro Ala Gly Pro Lys Pro Ser Ser
   1               5                  10                  15    
 Cys Glu Trp Ala Ala Cys Trp Ala Pro Ala Arg Cys Arg Ile Ser Ala
              20                  25                  30        
 Thr Ala Cys Gly Asn Ser Trp Asp Arg Pro Ala Gly Arg Thr Gln Leu
          35                  40                  45            
 Leu Trp Thr Pro Ala Ala Pro Thr Ala Met Ala Glu Val Gly Pro Gly
      50                  55                  60                
 His Thr Pro Ala His Pro Ser Gln Gly Ala Val Pro Pro Ser Arg Ala
  65                  70                  75                  80
 Ala Ala Glu Pro His Leu Lys Pro Ser Pro Ser Glu Leu Gln Thr Ala
                  85                  90                  95    
 Gly Pro Ala Ala Thr Ile Pro Ala Arg Leu Cys Thr Arg Lys Pro Arg
             100                 105                 110        
 Leu Val Tyr Thr Gln Cys Trp Tyr Val Lys Glu Pro Lys His Pro Glu
         115                 120                 125            
 Ile Val Thr Pro Trp Gly Thr Ala Ala Arg His Ser Trp Arg Gln His
     130                 135                 140                
 Gln Met Leu Ser Ala Ser Glu Arg Arg Cys Leu Pro Arg Asp Val Glu
 145                 150                 155                 160
 Gln Lys Leu Gly Pro Glu His Thr Gly Pro Cys Leu Asp Glu Gln Gly
                 165                 170                 175    
 Arg Glu Ala Glu Leu Ala Arg Ser Gly Pro Ser Ala Ala Gly Pro Val
             180                 185                 190        
 Arg Leu Lys Pro Gly Leu Val Pro Gly Leu Phe Leu Leu Ser Cys Thr
         195                 200                 205            
 Thr Ser Pro Ser Thr Cys Leu Pro Val Gly Gln Glu Gly Glu Arg Gly
     210                 215                 220                
 Met Leu
 225    



      <210> 776
      <211> 165
      <212> PRT
      <213> Homo sapiens


      <400> 776
 Met Glu Gly Glu Gly Arg Lys Cys Pro Trp Lys Gly Leu Arg Ala Arg
   1               5                  10                  15    
 Thr Gly Met Gly Gln Glu Val His Gly Ser Cys Trp Ala Leu Gly Ala
              20                  25                  30        
 Gly Gly Gly Gln Arg Gln Trp Val Gly Arg Ser Met Pro Pro Leu Ala
          35                  40                  45            
 Pro Gln Leu Cys Arg Ala Val Phe Leu Val Pro Ile Leu Leu Leu Leu
      50                  55                  60                
 Gln Val Lys Pro Leu Asn Gly Ser Pro Gly Pro Lys Asp Gly Ser Gln
  65                  70                  75                  80
 Thr Glu Lys Thr Pro Ser Ala Asp Gln Asn Gln Glu Gln Phe Glu Glu
                  85                  90                  95    
 His Phe Val Ala Ser Ser Val Gly Glu Met Trp Gln Val Val Asp Met
             100                 105                 110        
 Ala Gln Gln Glu Glu Asp Gln Ser Ser Lys Thr Ala Ala Val His Lys
         115                 120                 125            
 His Ser Phe His Leu Ser Phe Cys Phe Ser Leu Ala Ser Val Met Val
     130                 135                 140                
 Phe Ser Gly Gly Pro Leu Arg Arg Thr Phe Pro Asn Ile Gln Leu Cys
 145                 150                 155                 160
 Phe Met Leu Thr His
                 165



      <210> 777
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 777
 Met Ala Ser Lys Lys Phe Ala Val Lys Cys Gly Asn Phe Ala Val Leu
   1               5                  10                  15    
 Val Asp Leu His Ile Leu Pro Gln Gly Ser Asn Lys Asp Thr Ser Trp
              20                  25                  30        
 Phe Ser Glu Gln Lys Lys Glu Glu Val Cys Leu Leu Leu Lys Glu Thr
          35                  40                  45            
 Ile Asp Ser Arg Val Gln Glu Tyr Leu Glu Val Arg Lys Gln His Arg
      50                  55                  60                
 Pro Ser Asn Ala Glu Phe Thr Arg Ser Asn Pro Leu Ser Leu Lys Gly
  65                  70                  75                  80
 Arg His Arg Ala Leu
                  85



      <210> 778
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 778
 Met Leu Val Ala Ala Val Ile Ser Pro Tyr Pro Gln Leu Val Lys Lys
   1               5                  10                  15    
 Glu Ser Lys Met Ala Ala Gly Leu Cys Gln Leu Leu Ser Ser Ala Ala
              20                  25                  30        
 Ile Ile Arg Glu Leu Pro Leu Ser Phe Ser Pro Ala Ile Thr Thr Leu
          35                  40                  45            
 Pro His Gly His His His Leu Asn His Leu Ala Gly Gly Val Thr Ser
      50                  55                  60                





      <210> 779
      <211> 46
      <212> PRT
      <213> Homo sapiens


      <400> 779
 Met Asp Leu Trp Ser Cys Leu Phe Pro Val Met Leu Met Glu Pro Ser
   1               5                  10                  15    
 Lys Gly Leu Glu Asp Ser Glu Trp Lys Met Ala Leu Gln Met Arg Met
              20                  25                  30        
 Gln Leu Pro Cys Leu Val Leu Gly Glu Glu Gln Thr Cys Thr
          35                  40                  45    



      <210> 780
      <211> 963
      <212> PRT
      <213> Homo sapiens


      <400> 780
 Met Ala Ala His Leu Lys Lys Arg Val Tyr Glu Glu Phe Thr Lys Val
   1               5                  10                  15    
 Val Gln Pro Gln Glu Glu Ile Ala Thr Lys Lys Leu Arg Leu Thr Lys
              20                  25                  30        
 Pro Ser Lys Ser Ala Ala Leu His Ile Asp Leu Cys Lys Ala Thr Ser
          35                  40                  45            
 Pro Ala Asp Ala Leu Gln Tyr Leu Leu Gln Phe Ala Arg Lys Pro Val
      50                  55                  60                
 Glu Ala Glu Ser Val Glu Gly Val Val Arg Ile Leu Leu Glu His Tyr
  65                  70                  75                  80
 Tyr Lys Glu Asn Asp Pro Ser Val Arg Leu Lys Ile Ala Ser Leu Leu
                  85                  90                  95    
 Gly Leu Leu Ser Lys Thr Ala Gly Phe Ser Pro Asp Cys Ile Met Asp
             100                 105                 110        
 Asp Ala Ile Asn Ile Leu Gln Asn Glu Lys Ser His Gln Val Leu Ala
         115                 120                 125            
 Gln Leu Leu Asp Thr Leu Leu Ala Ile Gly Thr Lys Leu Pro Glu Asn
     130                 135                 140                
 Gln Ala Ile Gln Met Arg Leu Val Asp Val Ala Cys Lys His Leu Thr
 145                 150                 155                 160
 Asp Thr Ser His Gly Val Arg Asn Lys Cys Leu Gln Leu Leu Gly Asn
                 165                 170                 175    
 Leu Gly Ser Leu Glu Lys Ser Val Thr Lys Asp Ala Glu Gly Leu Ala
             180                 185                 190        
 Ala Arg Asp Val Gln Lys Ile Ile Gly Asp Tyr Phe Ser Asp Gln Asp
         195                 200                 205            
 Pro Arg Val Arg Thr Ala Ala Ile Lys Ala Met Leu Gln Leu His Glu
     210                 215                 220                
 Arg Gly Leu Lys Leu His Gln Thr Ile Tyr Asn Gln Ala Cys Lys Leu
 225                 230                 235                 240
 Leu Ser Asp Asp Tyr Glu Gln Val Arg Ser Ala Ala Val Gln Leu Ile
                 245                 250                 255    
 Trp Val Val Ser Gln Leu Tyr Pro Glu Ser Ile Val Pro Ile Pro Ser
             260                 265                 270        
 Ser Asn Glu Glu Ile Arg Leu Val Asp Asp Ala Phe Gly Lys Ile Cys
         275                 280                 285            
 His Met Val Ser Asp Gly Ser Trp Val Val Arg Val Gln Ala Ala Lys
     290                 295                 300                
 Leu Leu Gly Ser Met Glu Gln Val Ser Ser His Phe Leu Glu Gln Thr
 305                 310                 315                 320
 Leu Asp Lys Lys Leu Met Ser Asp Leu Arg Arg Lys Arg Thr Ala His
                 325                 330                 335    
 Glu Arg Ala Lys Glu Leu Tyr Ser Ser Gly Glu Phe Ser Ser Gly Arg
             340                 345                 350        
 Lys Trp Gly Asp Asp Ala Pro Lys Glu Glu Val Asp Thr Gly Ala Val
         355                 360                 365            
 Asn Leu Ile Glu Ser Gly Ala Cys Gly Ala Phe Val His Gly Leu Glu
     370                 375                 380                
 Asp Glu Met Tyr Glu Val Arg Ile Ala Ala Val Glu Ala Leu Cys Met
 385                 390                 395                 400
 Leu Ala Gln Ser Ser Pro Ser Phe Ala Glu Lys Cys Leu Asp Phe Leu
                 405                 410                 415    
 Val Asp Met Phe Asn Asp Glu Ile Glu Glu Val Arg Leu Gln Ser Ile
             420                 425                 430        
 His Thr Met Arg Lys Ile Ser Asn Asn Ile Thr Leu Arg Glu Asp Gln
         435                 440                 445            
 Leu Asp Thr Val Leu Ala Val Leu Glu Asp Ser Ser Arg Asp Ile Arg
     450                 455                 460                
 Glu Ala Leu His Glu Leu Leu Cys Cys Thr Asn Val Ser Thr Lys Glu
 465                 470                 475                 480
 Gly Ile His Leu Ala Leu Val Glu Leu Leu Lys Asn Leu Thr Lys Tyr
                 485                 490                 495    
 Pro Thr Asp Arg Asp Ser Ile Trp Lys Cys Leu Lys Phe Leu Gly Ser
             500                 505                 510        
 Arg His Pro Thr Leu Val Leu Pro Leu Val Pro Glu Leu Leu Ser Thr
         515                 520                 525            
 His Pro Phe Phe Asp Thr Ala Glu Pro Asp Met Asp Asp Pro Ala Tyr
     530                 535                 540                
 Ile Ala Val Leu Val Leu Ile Phe Asn Ala Ala Lys Thr Cys Pro Thr
 545                 550                 555                 560
 Met Pro Ala Leu Phe Ser Asp His Thr Phe Arg His Tyr Ala Tyr Leu
                 565                 570                 575    
 Arg Asp Ser Leu Ser His Leu Val Pro Ala Leu Arg Leu Pro Gly Arg
             580                 585                 590        
 Lys Leu Val Ser Ser Ala Val Ser Pro Ser Ile Ile Pro Gln Glu Asp
         595                 600                 605            
 Pro Ser Gln Gln Phe Leu Gln Gln Ser Leu Glu Arg Val Tyr Ser Leu
     610                 615                 620                
 Gln His Leu Asp Pro Gln Gly Ala Gln Glu Leu Leu Glu Phe Thr Ile
 625                 630                 635                 640
 Arg Asp Leu Gln Arg Leu Gly Glu Leu Gln Ser Glu Leu Ala Gly Val
                 645                 650                 655    
 Ala Asp Phe Ser Ala Thr Tyr Leu Arg Cys Gln Leu Leu Leu Ile Lys
             660                 665                 670        
 Ala Leu Gln Glu Lys Leu Trp Asn Val Ala Ala Pro Leu Tyr Leu Lys
         675                 680                 685            
 Gln Ser Asp Leu Ala Ser Ala Ala Ala Lys Gln Ile Met Glu Glu Thr
     690                 695                 700                
 Tyr Lys Met Glu Phe Met Tyr Ser Gly Val Glu Asn Lys Gln Val Val
 705                 710                 715                 720
 Ile Ile His His Met Arg Leu Gln Ala Lys Ala Leu Gln Leu Ile Val
                 725                 730                 735    
 Thr Ala Arg Thr Thr Arg Gly Leu Asp Pro Leu Phe Gly Met Cys Glu
             740                 745                 750        
 Lys Phe Leu Gln Glu Val Asp Phe Phe Gln Arg Tyr Phe Ile Ala Asp
         755                 760                 765            
 Leu Pro His Leu Gln Asp Ser Phe Val Asp Lys Leu Leu Asp Leu Met
     770                 775                 780                
 Pro Arg Leu Met Thr Ser Lys Pro Ala Glu Val Val Lys Ile Leu Gln
 785                 790                 795                 800
 Thr Met Leu Arg Gln Ser Ala Phe Leu His Leu Pro Leu Pro Glu Gln
                 805                 810                 815    
 Ile His Lys Ala Ser Ala Thr Ile Ile Glu Pro Ala Gly Glu Ser Asp
             820                 825                 830        
 Asn Pro Leu Arg Phe Thr Ser Gly Leu Val Val Ala Leu Asp Val Asp
         835                 840                 845            
 Ala Thr Leu Glu His Val Gln Asp Pro Gln Asn Thr Val Lys Val Gln
     850                 855                 860                
 Val Leu Tyr Pro Asp Gly Gln Ala Gln Met Ile His Pro Lys Pro Ala
 865                 870                 875                 880
 Asp Phe Arg Asn Pro Gly Pro Gly Arg His Arg Leu Ile Thr Gln Val
                 885                 890                 895    
 Tyr Leu Ser His Thr Ala Trp Thr Glu Ala Cys Gln Val Glu Val Arg
             900                 905                 910        
 Leu Leu Leu Ala Tyr Asn Ser Ser Ala Arg Ile Pro Lys Cys Pro Trp
         915                 920                 925            
 Met Glu Gly Gly Glu Met Ser Pro Gln Val Glu Thr Ser Ile Glu Gly
     930                 935                 940                
 Thr Ile Pro Phe Ser Lys Pro Val Lys Val Tyr Ile Met Pro Lys Pro
 945                 950                 955                 960
 Ala Arg Arg
            



      <210> 781
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 781
 Met Asn Met Lys Gln Lys Ser Val Tyr Gln Gln Thr Lys Ala Leu Leu
   1               5                  10                  15    
 Cys Lys Asn Phe Leu Lys Lys Trp Arg Met Lys Arg Glu Ser Leu Leu
              20                  25                  30        
 Glu Trp Gly Leu Ser Ile Leu Leu Gly Leu Cys Ile Ala Leu Phe Ser
          35                  40                  45            
 Ser Ser Met Arg Asn Val Gln Phe Pro Gly Met Ala Pro Gln Asn Leu
      50                  55                  60                
 Gly Arg Val Asp Lys Phe Asn Ser Ser Ser Leu Met Val Val Tyr Thr
  65                  70                  75                  80
 Pro Ile Ser Asn Leu Thr Gln Gln Ile Met Asn Lys Thr Ala Leu Ala
                  85                  90                  95    
 Pro Leu Leu Lys Gly Thr Ser Val Ile Gly Ala Pro Asn Lys Thr His
             100                 105                 110        
 Met Asp Glu Ile Leu Leu Glu Asn Leu Pro Tyr Ala Met Gly Ile Ile
         115                 120                 125            
 Phe Asn Glu Thr Phe Ser Tyr Lys Leu Ile Phe Phe Gln
     130                 135                 140    



      <210> 782
      <211> 225
      <212> PRT
      <213> Homo sapiens


      <400> 782
 Met Asn Asp Glu Asp Tyr Ser Thr Ile Tyr Asp Thr Ile Gln Asn Glu
   1               5                  10                  15    
 Arg Thr Tyr Glu Val Pro Asp Gln Pro Glu Glu Asn Glu Ser Pro His
              20                  25                  30        
 Tyr Asp Asp Val His Glu Tyr Leu Arg Pro Glu Asn Asp Leu Tyr Ala
          35                  40                  45            
 Thr Gln Leu Asn Thr His Glu Tyr Asp Phe Val Ser Val Tyr Thr Ile
      50                  55                  60                
 Lys Gly Glu Glu Thr Ser Leu Ala Ser Val Gln Ser Glu Asp Arg Gly
  65                  70                  75                  80
 Tyr Leu Leu Pro Asp Glu Ile Tyr Ser Glu Leu Gln Glu Ala His Pro
                  85                  90                  95    
 Gly Glu Pro Gln Glu Asp Arg Gly Ile Ser Met Glu Gly Leu Tyr Ser
             100                 105                 110        
 Ser Thr Gln Asp Gln Gln Leu Cys Ala Ala Glu Leu Gln Glu Asn Gly
         115                 120                 125            
 Ser Val Met Lys Glu Asp Leu Pro Ser Pro Ser Ser Phe Thr Ile Gln
     130                 135                 140                
 His Ser Lys Ala Phe Ser Thr Thr Lys Tyr Ser Cys Tyr Ser Asp Ala
 145                 150                 155                 160
 Glu Gly Leu Glu Glu Lys Glu Gly Ala His Met Asn Pro Glu Ile Tyr
                 165                 170                 175    
 Leu Phe Val Lys Gly Lys Pro Lys His Phe Ala Glu Glu Phe Asp Val
             180                 185                 190        
 Gly Glu Lys Lys Asn Lys Glu Pro Trp Leu Thr Leu Glu Ile Ile Val
         195                 200                 205            
 Ser Tyr Gly Pro Leu Leu Arg Lys Cys Ala Asn Glu Lys Ala Asp Ile
     210                 215                 220                
 Arg
 225



      <210> 783
      <211> 165
      <212> PRT
      <213> Homo sapiens


      <400> 783
 Met Glu Tyr Met Ala Glu Ser Thr Asp Arg Ser Pro Gly His Ile Leu
   1               5                  10                  15    
 Cys Cys Glu Cys Gly Val Pro Ile Ser Pro Asn Pro Ala Asn Ile Cys
              20                  25                  30        
 Val Ala Cys Leu Arg Ser Lys Val Asp Ile Ser Gln Gly Ile Pro Lys
          35                  40                  45            
 Gln Val Ser Ile Ser Phe Cys Lys Gln Cys Gln Arg Tyr Phe Gln Pro
      50                  55                  60                
 Pro Gly Thr Trp Ile Gln Cys Ala Leu Glu Ser Arg Glu Leu Leu Ala
  65                  70                  75                  80
 Leu Cys Leu Lys Lys Ile Lys Ala Pro Leu Ser Lys Val Arg Leu Val
                  85                  90                  95    
 Asp Ala Gly Phe Val Trp Thr Glu Pro His Ser Lys Arg Leu Lys Val
             100                 105                 110        
 Lys Leu Thr Ile Gln Lys Glu Val Met Asn Gly Ala Ile Leu Gln Gln
         115                 120                 125            
 Val Phe Val Val Asp Tyr Val Val Gln Ser Gln Met Cys Gly Asp Cys
     130                 135                 140                
 His Arg Val Glu Ala Lys Asp Phe Trp Lys Gly Cys Asp Ser Ser Glu
 145                 150                 155                 160
 Ala Lys Asp Phe Ala
                 165



      <210> 784
      <211> 373
      <212> PRT
      <213> Homo sapiens


      <400> 784
 Met Ser Ser Gly Asn Tyr Gln Gln Ser Glu Ala Leu Ser Lys Pro Thr
   1               5                  10                  15    
 Phe Ser Glu Glu Gln Ala Ser Ala Leu Val Glu Ser Val Phe Gly Leu
              20                  25                  30        
 Lys Val Ser Lys Val Arg Pro Leu Pro Ser Tyr Asp Asp Gln Asn Phe
          35                  40                  45            
 His Val Tyr Val Ser Lys Thr Lys Asp Gly Pro Thr Glu Tyr Val Leu
      50                  55                  60                
 Lys Ile Ser Asn Thr Lys Ala Ser Lys Asn Pro Asp Leu Ile Glu Val
  65                  70                  75                  80
 Gln Asn His Ile Ile Met Phe Leu Lys Ala Ala Gly Phe Pro Thr Ala
                  85                  90                  95    
 Ser Val Cys His Thr Lys Gly Asp Asn Thr Ala Ser Leu Val Ser Val
             100                 105                 110        
 Asp Ser Gly Ser Glu Ile Lys Ser Tyr Leu Val Arg Leu Leu Thr Tyr
         115                 120                 125            
 Leu Pro Gly Arg Pro Ile Ala Glu Leu Pro Val Ser Pro Gln Leu Leu
     130                 135                 140                
 Tyr Glu Ile Gly Lys Leu Ala Ala Lys Leu Asp Lys Thr Leu Gln Arg
 145                 150                 155                 160
 Phe His His Pro Lys Leu Ser Ser Leu His Arg Glu Asn Phe Ile Trp
                 165                 170                 175    
 Asn Leu Lys Asn Val Pro Leu Leu Glu Lys Tyr Leu Tyr Ala Leu Gly
             180                 185                 190        
 Gln Asn Arg Asn Arg Glu Ile Val Glu His Val Ile His Leu Phe Lys
         195                 200                 205            
 Glu Glu Val Met Thr Lys Leu Ser His Phe Arg Glu Cys Ile Asn His
     210                 215                 220                
 Gly Asp Leu Asn Asp His Asn Ile Leu Ile Glu Ser Ser Lys Ser Ala
 225                 230                 235                 240
 Ser Gly Asn Ala Glu Tyr Gln Val Ser Gly Ile Leu Asp Phe Gly Asp
                 245                 250                 255    
 Met Ser Tyr Gly Tyr Tyr Val Phe Glu Val Ala Ile Thr Ile Met Tyr
             260                 265                 270        
 Met Met Ile Glu Ser Lys Ser Pro Ile Gln Val Gly Gly His Val Leu
         275                 280                 285            
 Ala Gly Phe Glu Ser Ile Thr Pro Leu Thr Ala Val Glu Lys Gly Ala
     290                 295                 300                
 Leu Phe Leu Leu Val Cys Ser Arg Phe Cys Gln Ser Leu Val Met Ala
 305                 310                 315                 320
 Ala Tyr Ser Cys Gln Leu Tyr Pro Glu Asn Lys Asp Tyr Leu Met Val
                 325                 330                 335    
 Thr Ala Lys Thr Gly Trp Lys His Leu Gln Gln Met Phe Asp Met Gly
             340                 345                 350        
 Gln Lys Ala Val Glu Glu Ile Trp Phe Glu Thr Ala Lys Ser Tyr Glu
         355                 360                 365            
 Ser Gly Ile Ser Met
     370            



      <210> 785
      <211> 471
      <212> PRT
      <213> Homo sapiens


      <400> 785
 Met Glu Leu Ser Ser Lys Lys Lys Leu His Ala Leu Ser Leu Ala Glu
   1               5                  10                  15    
 Lys Ile Gln Val Leu Glu Leu Leu Asp Glu Ser Lys Met Ser Gln Ser
              20                  25                  30        
 Glu Val Ala Arg Arg Phe Gln Val Ser Gln Pro Gln Ile Ser Arg Ile
          35                  40                  45            
 Cys Lys Asn Lys Glu Lys Leu Leu Ala Asp Trp Cys Ser Gly Thr Ala
      50                  55                  60                
 Asn Arg Glu Arg Lys Arg Lys Arg Glu Ser Lys Tyr Ser Gly Ile Asp
  65                  70                  75                  80
 Glu Ala Leu Leu Cys Trp Tyr His Ile Ala Arg Ala Lys Ala Trp Asp
                  85                  90                  95    
 Val Thr Gly Pro Met Leu Leu His Lys Ala Lys Glu Leu Ala Asp Ile
             100                 105                 110        
 Met Gly Gln Asp Phe Val Pro Ser Ile Gly Trp Leu Val Arg Trp Lys
         115                 120                 125            
 Arg Arg Asn Asn Val Gly Phe Gly Ala Arg His Val Leu Ala Pro Ser
     130                 135                 140                
 Phe Pro Pro Glu Pro Pro Pro Pro Gly Leu Thr Ser Gln Ala Gln Leu
 145                 150                 155                 160
 Pro Leu Ser Leu Lys Asp Phe Ser Pro Glu Asp Val Phe Gly Cys Ala
                 165                 170                 175    
 Glu Leu Pro Leu Leu Tyr Arg Ala Val Pro Gly Ser Phe Gly Ala Cys
             180                 185                 190        
 Asp Gln Val Gln Val Leu Leu Cys Ala Asn Ser Arg Gly Thr Glu Lys
         195                 200                 205            
 Arg Arg Val Leu Leu Gly Gly Leu Gln Ala Ala Pro Arg Cys Phe Phe
     210                 215                 220                
 Gly Ile Arg Ser Glu Ala Leu Pro Ala Ser Tyr His Pro Asp Leu Gly
 225                 230                 235                 240
 Ile Pro Trp Leu Glu Trp Leu Ala Gln Phe Asp Arg Asp Met Gly Gln
                 245                 250                 255    
 Gln Gly Arg Gln Val Ala Leu Leu Leu Ala Ala Arg Val Val Glu Glu
             260                 265                 270        
 Leu Ala Gly Leu Pro Gly Leu Tyr His Val Lys Leu Leu Pro Leu Ala
         275                 280                 285            
 Ala Ser Ser Thr Thr Pro Pro Leu Pro Ser Ser Val Val Arg Ala Phe
     290                 295                 300                
 Lys Ala His Tyr Arg His Arg Leu Leu Gly Lys Leu Ala Ala Ile Gln
 305                 310                 315                 320
 Ser Glu Arg Asp Gly Thr Ser Leu Ala Glu Ala Gly Ala Gly Ile Thr
                 325                 330                 335    
 Val Leu Asp Ala Leu His Val Ala Ser Ala Ala Trp Ala Lys Val Pro
             340                 345                 350        
 Pro Gln Leu Ile Phe Ser Ser Phe Ile Gln Glu Gly Leu Ala Pro Gly
         355                 360                 365            
 Lys Thr Pro Pro Ser Ser His Lys Thr Ser Glu Met Pro Pro Val Pro
     370                 375                 380                
 Gly Gly Leu Ser Leu Glu Glu Phe Ser Arg Phe Val Asp Leu Glu Gly
 385                 390                 395                 400
 Glu Glu Pro Arg Ser Gly Val Cys Lys Glu Glu Ile Gly Thr Glu Asp
                 405                 410                 415    
 Glu Lys Gly Asp Arg Glu Gly Ala Phe Glu Pro Leu Pro Thr Lys Ala
             420                 425                 430        
 Asp Ala Leu Arg Ala Leu Gly Thr Leu Arg Arg Trp Phe Glu Cys Asn
         435                 440                 445            
 Ser Thr Ser Pro Glu Leu Phe Glu Lys Phe Tyr Asp Cys Glu Glu Glu
     450                 455                 460                
 Val Glu Arg Leu Cys Cys Leu
 465                 470    



      <210> 786
      <211> 37
      <212> PRT
      <213> Homo sapiens


      <400> 786
 Met Gln Ala Ala Ser Phe Gly Arg Gly Arg Asn Gly Leu Asp Asn Trp
   1               5                  10                  15    
 Gly Ile Ala Ala Leu Leu Gly Leu Leu Gln Leu Arg Phe Lys Ala Glu
              20                  25                  30        
 Pro Thr Leu Gly Gly
          35        



      <210> 787
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 787
 Met Ala Leu Ala Asn Gln Leu Ala Phe Leu Asp Ala Leu Pro Gln His
   1               5                  10                  15    
 Met Asp Ser Ala Leu Met Asn Leu Thr Thr Met Ala Met Asp Leu Asp
              20                  25                  30        
 Lys Val Ser Val Ser Met Cys Asn Leu Ser Leu Glu Glu Ile Cys Val
          35                  40                  45            
 Gly Trp Val Asn Phe Gly Ser Leu Pro Asn Asn Ala Cys
      50                  55                  60    



      <210> 788
      <211> 315
      <212> PRT
      <213> Homo sapiens


      <400> 788
 Met Pro Ser Val Ser Lys Ala Ala Ala Ala Ala Leu Ser Gly Ser Pro
   1               5                  10                  15    
 Pro Gln Thr Glu Lys Pro Thr His Tyr Arg Tyr Leu Lys Glu Phe Arg
              20                  25                  30        
 Thr Glu Gln Cys Pro Leu Phe Ser Gln His Lys Cys Ala Gln His Arg
          35                  40                  45            
 Pro Phe Thr Cys Phe His Trp His Phe Leu Asn Gln Arg Arg Arg Arg
      50                  55                  60                
 Pro Leu Arg Arg Arg Asp Gly Thr Phe Asn Tyr Ser Pro Asp Val Tyr
  65                  70                  75                  80
 Cys Ser Lys Tyr Asn Glu Ala Thr Gly Val Cys Pro Asp Gly Asp Glu
                  85                  90                  95    
 Cys Pro Tyr Leu His Arg Thr Thr Gly Asp Thr Glu Arg Lys Tyr His
             100                 105                 110        
 Leu Arg Tyr Tyr Lys Thr Gly Thr Cys Ile His Glu Thr Asp Ala Arg
         115                 120                 125            
 Gly His Cys Val Lys Asn Gly Leu His Cys Ala Phe Ala His Gly Pro
     130                 135                 140                
 Leu Asp Leu Arg Pro Pro Val Cys Asp Val Arg Glu Leu Gln Ala Gln
 145                 150                 155                 160
 Glu Ala Leu Gln Asn Gly Gln Leu Gly Gly Gly Glu Gly Val Pro Asp
                 165                 170                 175    
 Leu Gln Pro Gly Val Leu Ala Ser Gln Ala Met Ile Glu Lys Ile Leu
             180                 185                 190        
 Ser Glu Asp Pro Arg Trp Gln Asp Ala Asn Phe Val Leu Gly Ser Tyr
         195                 200                 205            
 Lys Thr Glu Gln Cys Pro Lys Pro Pro Arg Leu Cys Arg Gln Gly Tyr
     210                 215                 220                
 Ala Cys Pro His Tyr His Asn Ser Arg Asp Arg Arg Arg Asn Pro Arg
 225                 230                 235                 240
 Arg Phe Gln Tyr Arg Ser Thr Pro Cys Pro Ser Val Lys His Gly Asp
                 245                 250                 255    
 Glu Trp Gly Glu Pro Ser Arg Cys Asp Gly Gly Asp Gly Cys Gln Tyr
             260                 265                 270        
 Cys His Ser Arg Thr Glu Gln Gln Phe His Pro Glu Val Arg Pro Ser
         275                 280                 285            
 Asn Pro Pro Gly Val Gly Val Ala Gly Arg Ser Gln Arg Ser Cys Gly
     290                 295                 300                
 Val His Ser Val Val Ile Thr Gln Lys Glu Gln
 305                 310                 315



      <210> 789
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 789
 Met Lys Arg Ala Tyr Ser Pro Pro Gly Ile Ser Tyr Phe Thr Pro Cys
   1               5                  10                  15    
 Ser Leu Ser Cys Thr His Thr His Thr His Thr Pro Gln Glu Thr Leu
              20                  25                  30        
 Pro Gln Leu Ser Pro Asn Pro Ala Glu Gln Pro Ser Val Ala Pro Gln
          35                  40                  45            
 Cys Leu Lys Asn Met Ile Gln Thr Phe Pro Ala Tyr Leu Cys Leu Pro
      50                  55                  60                
 Leu Phe Tyr Val Leu Asp Leu Ala Leu Ala Ser Ala Pro Val Leu Ser
  65                  70                  75                  80
 His Ser Ala Leu Leu
                  85



      <210> 790
      <211> 294
      <212> PRT
      <213> Homo sapiens


      <400> 790
 Met Ala Gly Gln Pro Ala Ala Thr Gly Ser Pro Ser Ala Asp Lys Asp
   1               5                  10                  15    
 Gly Met Glu Pro Asn Val Val Ala Arg Ile Ser Gln Trp Ala Asp Asp
              20                  25                  30        
 His Leu Arg Leu Val Arg Asn Ile Ser Thr Gly Met Ala Ile Ala Gly
          35                  40                  45            
 Ile Met Leu Leu Leu Arg Ser Ile Arg Leu Thr Ser Lys Phe Thr Ser
      50                  55                  60                
 Ser Ser Asp Ile Pro Val Glu Phe Ile Arg Arg Asn Val Lys Leu Arg
  65                  70                  75                  80
 Gly Arg Leu Arg Arg Ile Thr Glu Asn Gly Leu Glu Ile Glu His Ile
                  85                  90                  95    
 Pro Ile Thr Leu Pro Ile Ile Ala Ser Leu Arg Lys Glu Pro Arg Gly
             100                 105                 110        
 Ala Leu Leu Val Lys Leu Ala Gly Val Glu Leu Ala Glu Thr Gly Lys
         115                 120                 125            
 Ala Trp Leu Gln Lys Glu Leu Lys Pro Ser Gln Leu Leu Trp Phe Gln
     130                 135                 140                
 Leu Leu Gly Lys Glu Asn Ser Ala Leu Phe Cys Tyr Leu Leu Val Asn
 145                 150                 155                 160
 Lys Gly Gly Tyr Phe Ser Val Asn Leu Asn Glu Glu Ile Leu Arg Arg
                 165                 170                 175    
 Gly Leu Gly Lys Thr Val Leu Val Lys Gly Leu Lys Tyr Asp Ser Lys
             180                 185                 190        
 Ile Tyr Trp Thr Val His Arg Asn Leu Leu Lys Ala Glu Leu Thr Ala
         195                 200                 205            
 Leu Lys Lys Gly Glu Gly Ile Trp Lys Glu Asp Ser Glu Lys Glu Ser
     210                 215                 220                
 Tyr Leu Glu Lys Phe Lys Asp Ser Trp Arg Glu Ile Trp Lys Lys Asp
 225                 230                 235                 240
 Ser Phe Leu Lys Thr Thr Gly Ser Asp Phe Ser Leu Lys Lys Glu Ser
                 245                 250                 255    
 Tyr Tyr Glu Lys Leu Lys Arg Thr Tyr Glu Ile Trp Lys Asp Asn Met
             260                 265                 270        
 Asn Asn Cys Ser Leu Ile Leu Lys Phe Arg Glu Leu Ile Ser Arg Ile
         275                 280                 285            
 Asn Phe Arg Arg Lys Gly
     290                



      <210> 791
      <211> 160
      <212> PRT
      <213> Homo sapiens


      <400> 791
 Met Val Pro Ala Ser Ala Ser Gly Glu Gly Phe Arg Lys Leu Pro Leu
   1               5                  10                  15    
 Lys Ala Glu Glu Glu Gly Glu Gln Ala Ser Ser His Gly Lys Arg Gly
              20                  25                  30        
 Gly Lys Arg Glu Gly Arg Glu Val Lys Asn Cys Thr Val Tyr Ile His
          35                  40                  45            
 Asp Asp Ser Met Phe Glu Pro Glu Glu Gln Phe Arg Val Tyr Leu Gly
      50                  55                  60                
 Leu Pro Leu Gly Asn His Trp Ser Gly Ala Arg Ile Gly Lys Asn Asn
  65                  70                  75                  80
 Met Ala Thr Ile Thr Ile Ser Asn Asp Glu Asp Ala Pro Thr Ile Glu
                  85                  90                  95    
 Phe Glu Glu Ala Ala Tyr Gln Val Arg Glu Pro Ala Gly Pro Asp Ala
             100                 105                 110        
 Ile Ala Ile Leu Asn Ile Lys Val Ile Arg Arg Gly Asp Gln Asn Arg
         115                 120                 125            
 Thr Ser Lys Val Arg Cys Ser Thr Arg Asp Gly Ser Ala Gln Ser Gly
     130                 135                 140                
 Val Asp Tyr Tyr Pro Lys Ser Arg Val Leu Lys Phe Ser Pro Gly Asn
 145                 150                 155                 160





      <210> 792
      <211> 412
      <212> PRT
      <213> Homo sapiens


      <400> 792
 Met Thr Val Val Cys His Leu Glu Gly Ser Gly Gln Trp Pro Gln Asp
   1               5                  10                  15    
 Ala Glu Ala Val Gln Arg Val Arg Ala Ala Phe Gln Leu Arg Leu Ala
              20                  25                  30        
 Glu Leu Leu Thr Gln Gln His Gly Leu Gln Cys Arg Ala Thr Ala Thr
          35                  40                  45            
 His Thr Asp Val Leu Lys Asp Gly Phe Val Phe Arg Ile Arg Val Ala
      50                  55                  60                
 Tyr Gln Arg Glu Pro Gln Ile Leu Lys Glu Val Gln Ser Pro Glu Gly
  65                  70                  75                  80
 Met Ile Ser Leu Arg Asp Thr Ala Ala Ser Leu Arg Leu Glu Arg Asp
                  85                  90                  95    
 Thr Arg Gln Leu Pro Leu Leu Thr Ser Ala Leu His Gly Leu Gln Gln
             100                 105                 110        
 Gln His Pro Ala Phe Ser Gly Val Ala Arg Leu Ala Lys Arg Trp Val
         115                 120                 125            
 Arg Ala Gln Leu Leu Gly Glu Gly Phe Ala Asp Glu Ser Leu Asp Leu
     130                 135                 140                
 Val Ala Ala Ala Leu Phe Leu His Pro Glu Pro Phe Thr Pro Pro Ser
 145                 150                 155                 160
 Ser Pro Gln Val Gly Phe Leu Arg Phe Leu Phe Leu Val Ser Thr Phe
                 165                 170                 175    
 Asp Trp Lys Asn Asn Pro Leu Phe Val Asn Leu Asn Asn Glu Leu Thr
             180                 185                 190        
 Val Glu Glu Gln Val Glu Ile Arg Ser Gly Phe Leu Ala Ala Arg Ala
         195                 200                 205            
 Gln Leu Pro Val Met Val Ile Val Thr Pro Gln Asp Arg Lys Asn Ser
     210                 215                 220                
 Val Trp Thr Gln Asp Gly Pro Ser Ala Gln Ile Leu Gln Gln Leu Val
 225                 230                 235                 240
 Val Leu Ala Ala Glu Ala Leu Pro Met Leu Glu Lys Gln Leu Met Asp
                 245                 250                 255    
 Pro Arg Gly Pro Gly Asp Ile Arg Thr Val Phe Arg Pro Pro Leu Asp
             260                 265                 270        
 Ile Tyr Asp Val Leu Ile Arg Leu Ser Pro Arg His Ile Pro Arg His
         275                 280                 285            
 Arg Gln Ala Val Asp Ser Pro Ala Ala Ser Phe Cys Arg Gly Leu Leu
     290                 295                 300                
 Ser Gln Pro Gly Pro Ser Ser Leu Met Pro Val Leu Gly Tyr Asp Pro
 305                 310                 315                 320
 Pro Gln Leu Tyr Leu Thr Gln Leu Arg Glu Ala Phe Gly Asp Leu Ala
                 325                 330                 335    
 Leu Phe Phe Tyr Asp Gln His Gly Gly Glu Val Ile Gly Val Leu Trp
             340                 345                 350        
 Lys Pro Thr Ser Phe Gln Pro Gln Pro Phe Lys Ala Ser Ser Thr Lys
         355                 360                 365            
 Gly Arg Met Val Met Ser Arg Gly Gly Glu Leu Val Met Val Pro Asn
     370                 375                 380                
 Val Glu Ala Ile Leu Glu Asp Phe Ala Val Leu Gly Glu Gly Leu Val
 385                 390                 395                 400
 Gln Thr Val Glu Ala Arg Ser Glu Arg Trp Thr Val
                 405                 410        



      <210> 793
      <211> 91
      <212> PRT
      <213> Homo sapiens


      <400> 793
 Met Glu Leu Glu Pro Met Tyr Ser Asn Val Asn Pro Gly Asp Ser Asn
   1               5                  10                  15    
 Pro Ile Tyr Ser Gln Ile Trp Ser Ile Gln His Thr Lys Glu Asn Ser
              20                  25                  30        
 Ala Asn Cys Pro Met Met His Gln Glu His Glu Glu Leu Thr Val Leu
          35                  40                  45            
 Tyr Ser Glu Leu Lys Lys Thr His Pro Asp Asp Ser Ala Gly Glu Ala
      50                  55                  60                
 Ser Ser Arg Gly Arg Ala His Glu Glu Asp Asp Glu Glu Asn Tyr Glu
  65                  70                  75                  80
 Asn Val Pro Arg Val Leu Leu Ala Ser Asp His
                  85                  90    



      <210> 794
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 794
 Met Ala Ser Ser Gly Gly Glu Leu Gly Ser Leu Phe Asp His His Val
   1               5                  10                  15    
 Gln Arg Ala Val Cys Asp Thr Arg Ala Lys Tyr Arg Glu Gly Arg Arg
              20                  25                  30        
 Pro Arg Ala Val Lys Val Tyr Thr Ile Asn Leu Glu Ser Gln Tyr Leu
          35                  40                  45            
 Leu Ile Gln Gly Val Pro Ala Val Gly Val Met Lys Glu Leu Val Glu
      50                  55                  60                
 Arg Phe Ala Leu Tyr Gly Ala Ile Glu Gln Tyr Asn Ala Leu Asp Glu
  65                  70                  75                  80
 Tyr Pro Ala Glu Asp Phe Thr Glu Val Tyr Leu Ile Lys Phe Met Asn
                  85                  90                  95    
 Leu Gln Ser Ala Arg Thr Ala Lys Arg Lys Met Asp Glu Gln Ser Phe
             100                 105                 110        
 Phe Gly Gly Leu Leu His Val Cys Tyr Ala Pro Glu Phe Glu Thr Val
         115                 120                 125            
 Glu Glu Thr Arg Lys Lys Leu Gln Met Arg Gln Gly Ile Cys
     130                 135                 140        



      <210> 795
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 795
 Met Glu Pro Ser Leu Leu Glu Asp Ile Ile Leu Leu Arg Glu Leu His
   1               5                  10                  15    
 Val Asn His Tyr Arg Phe Ser Leu Ser Trp Pro Arg Leu Leu Pro Thr
              20                  25                  30        
 Gly Ile Arg Ala Glu Gln Val Asn Lys Lys Gly Ile Glu Phe Tyr Ser
          35                  40                  45            
 Asp Leu Ile Asp Ala Leu Leu Ser Ser Asn Ile Thr Pro Ile Val Thr
      50                  55                  60                
 Leu His His Trp Asp Leu Pro Gln Leu Leu Gln Val Lys Tyr Gly Gly
  65                  70                  75                  80
 Trp Gln Asn Val Ser Met Ala Asn Tyr Phe Arg Asp Tyr Ala Asn Leu
                  85                  90                  95    
 Cys Phe Glu Ala Phe Gly Asp Arg Val Lys His Trp Ile Thr Phe Ser
             100                 105                 110        
 Asp Pro Arg Ala Met Ala Glu Lys Gly Tyr Glu Thr Gly His His Ala
         115                 120                 125            
 Pro Gly Leu Lys Leu Arg Gly Thr Gly Leu Tyr Lys Ala Ala His His
     130                 135                 140                
 Ile Ile Lys Ala His Ala Lys Ala Trp His Ser Tyr Asn Thr Thr Trp
 145                 150                 155                 160
 Arg Asn Lys Gln Gln Gly Leu Gly Glu Phe His
                 165                 170    



      <210> 796
      <211> 52
      <212> PRT
      <213> Homo sapiens


      <400> 796
 Met Ala Glu Lys Gly Tyr Glu Thr Gly His His Ala Pro Gly Leu Lys
   1               5                  10                  15    
 Leu Arg Gly Thr Gly Leu Tyr Lys Ala Ala His His Ile Ile Lys Val
              20                  25                  30        
 Arg Trp Val Leu Leu Val Glu Glu Gln Pro Gln Gly Gln Leu Ser Leu
          35                  40                  45            
 Pro Gln Gly Leu
      50        



      <210> 797
      <211> 51
      <212> PRT
      <213> Homo sapiens


      <400> 797
 Met Lys Leu Arg Glu Cys Pro Ala Leu Arg Trp Ser Gln Leu Ser Gln
   1               5                  10                  15    
 His Lys Leu Glu Cys Leu Leu Leu Tyr Leu Ala Glu Ser Ser Gly Leu
              20                  25                  30        
 Arg Thr Gly Asn Val Gly Val Leu His Pro Thr Leu Thr Asp Gly Ser
          35                  40                  45            
 Gly Lys Glu
      50    



      <210> 798
      <211> 354
      <212> PRT
      <213> Homo sapiens


      <400> 798
 Met Asp Phe Ile Leu Glu Asp Met Asp Leu Ala Ala Asn Glu Ile Ser
   1               5                  10                  15    
 Ile Tyr Asp Lys Leu Ser Glu Thr Val Asp Leu Val Arg Gln Thr Gly
              20                  25                  30        
 His Gln Cys Gly Met Ser Glu Lys Ala Ile Glu Lys Phe Ile Arg Gln
          35                  40                  45            
 Leu Leu Glu Lys Asn Glu Pro Gln Arg Pro Pro Pro Gln Tyr Pro Leu
      50                  55                  60                
 Leu Ile Val Val Tyr Lys Val Leu Ala Thr Leu Gly Leu Ile Leu Leu
  65                  70                  75                  80
 Thr Ala Tyr Phe Val Ile Gln Pro Phe Ser Pro Leu Ala Pro Glu Pro
                  85                  90                  95    
 Val Leu Ser Gly Ala His Thr Trp Arg Ser Leu Ile His His Ile Arg
             100                 105                 110        
 Leu Met Ser Leu Pro Ile Ala Lys Lys Tyr Met Ser Glu Asn Lys Gly
         115                 120                 125            
 Val Pro Leu His Gly Gly Asp Glu Asp Arg Pro Phe Pro Asp Phe Asp
     130                 135                 140                
 Pro Trp Trp Thr Asn Asp Cys Glu Gln Asn Glu Ser Glu Pro Ile Pro
 145                 150                 155                 160
 Ala Asn Cys Thr Gly Cys Ala Gln Lys His Leu Lys Val Met Leu Leu
                 165                 170                 175    
 Glu Asp Ala Pro Arg Lys Phe Glu Arg Leu His Pro Leu Val Ile Lys
             180                 185                 190        
 Thr Gly Lys Pro Leu Leu Glu Glu Glu Ile Gln His Phe Leu Cys Gln
         195                 200                 205            
 Tyr Pro Glu Ala Thr Glu Gly Phe Ser Glu Gly Phe Phe Ala Lys Trp
     210                 215                 220                
 Trp Arg Cys Phe Pro Glu Arg Trp Phe Pro Phe Pro Tyr Pro Trp Arg
 225                 230                 235                 240
 Arg Pro Leu Asn Arg Ser Gln Met Leu Arg Glu Leu Phe Pro Val Phe
                 245                 250                 255    
 Thr His Leu Pro Phe Pro Lys Asp Ala Ser Leu Asn Lys Cys Ser Phe
             260                 265                 270        
 Leu His Pro Glu Pro Val Val Gly Ser Lys Met His Lys Met Pro Asp
         275                 280                 285            
 Leu Phe Ile Ile Gly Ser Gly Glu Ala Met Leu Gln Leu Ile Pro Pro
     290                 295                 300                
 Phe Gln Cys Arg Arg His Cys Gln Ser Val Ala Met Pro Ile Glu Pro
 305                 310                 315                 320
 Gly Asp Ile Gly Tyr Val Asp Thr Thr His Trp Lys Val Tyr Val Ile
                 325                 330                 335    
 Ala Arg Gly Val Gln Pro Leu Val Ile Cys Asp Gly Thr Ala Phe Ser
             340                 345                 350        
 Glu Leu
        



      <210> 799
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 799
 Met Asp Arg Leu Cys Cys Leu Arg Pro Pro Pro His Arg Asp Pro Ala
   1               5                  10                  15    
 Arg Leu Leu Leu Ala Ser Thr Asp Asp Lys Arg Asn Ser Pro Lys Ile
              20                  25                  30        
 Arg Pro Leu Gln Pro Ala Val Pro Ala Cys Leu Pro Ala Thr Val Arg
          35                  40                  45            
 Pro Ala Leu Ala Ser Ser Ser Ala Gly Leu Ser Ala Gly Phe Trp Gly
      50                  55                  60                
 Gln Lys Ser Gly Glu Pro Arg Gly Arg Val Arg Gly Asp Gln Val Arg
  65                  70                  75                  80
 Ala Ala Thr Phe Leu Val Ile Ser Pro Met Gly Arg Arg Gly Trp Arg
                  85                  90                  95    
 Asp Thr Ala Pro Pro Ala Ser Pro His His Phe Cys Leu Thr Arg Lys
             100                 105                 110        
 Arg Pro Phe Phe Val Pro Gly Val Tyr Leu Arg Gly Leu Val Pro Glu
         115                 120                 125            
 Ala Pro His Gly Glu Cys Trp Gly Pro Ala Val Pro Trp Gly Ser Arg
     130                 135                 140                
 Trp Gly His Pro Trp Gln Gly Arg Tyr Asn Phe Phe Gln Gln Arg Ser
 145                 150                 155                 160
 Pro Leu Gly Gly Leu Cys Leu Trp His Leu
                 165                 170



      <210> 800
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 800
 Met Thr Gly Leu Phe Lys Ala Ser Tyr Phe Tyr Thr Asp Tyr Phe Thr
   1               5                  10                  15    
 Asp His Arg Phe Ile Leu Lys Gly Lys Ile Ser His Ile Ile Lys Gln
              20                  25                  30        
 Trp Lys Met Cys Ser Met Leu Trp Cys Val Arg Pro Ser Val Tyr Gln
          35                  40                  45            
 Val Ser Pro Leu Ser Ala Glu Leu Trp Thr Leu Tyr Val Pro Asn Arg
      50                  55                  60                





      <210> 801
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 801
 Met Cys Leu Gly Thr Leu Arg Pro Thr Asn Asp Ser Ala Leu Met Glu
   1               5                  10                  15    
 Gln Pro Ser Val Trp Gly Lys Val Leu Glu Val His Ser Phe Arg Lys
              20                  25                  30        
 Pro Leu Thr Ser Leu Tyr His Ala Leu Ser Glu Lys Leu Arg Ile Arg
          35                  40                  45            
 Lys Glu Gln Asp Pro Gln Glu Thr Leu Met Ser Gly
      50                  55                  60



      <210> 802
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 802
 Met Glu Gly Ala Gly Tyr Arg Val Val Phe Glu Lys Gly Gly Val Tyr
   1               5                  10                  15    
 Leu His Thr Ser Ala Lys Lys Tyr Gln Asp Arg Asp Ser Leu Ile Ala
              20                  25                  30        
 Gly Val Ile Arg Val Val Glu Lys Asp Asn Asp Val Leu Leu His Trp
          35                  40                  45            
 Ala Pro Val Glu Glu Ala Gly Asp Ser Thr Gln Ile Leu Phe Ser Lys
      50                  55                  60                
 Lys Val Gly Ser Thr Arg Phe Ala Leu Leu His Ser Leu Phe Phe
  65                  70                  75                



      <210> 803
      <211> 337
      <212> PRT
      <213> Homo sapiens


      <400> 803
 Met Gly Val Pro Ser Ser Pro Val Arg Ala Pro Pro Asp Ser Pro Thr
   1               5                  10                  15    
 Thr Pro Val Arg Ser Leu Arg Tyr Arg Arg Val Asn Ser Pro Glu Ser
              20                  25                  30        
 Glu Arg Leu Ser Thr Ala Asp Gly Arg Val Glu Leu Pro Glu Arg Arg
          35                  40                  45            
 Ser Arg Met Asp Leu Pro Gly Ser Pro Ser Arg Gln Ala Cys Ser Ser
      50                  55                  60                
 Gln Pro Ala Gln Met Leu Ser Val Asp Thr Gly His Ala Asp Arg Gln
  65                  70                  75                  80
 Ala Ser Gly Arg Met Asp Val Ser Ala Ser Val Glu Gln Glu Ala Leu
                  85                  90                  95    
 Ser Asn Ala Phe Arg Ser Val Pro Leu Ala Glu Glu Glu Asp Phe Asp
             100                 105                 110        
 Ser Lys Glu Trp Val Ile Ile Asp Lys Glu Thr Glu Leu Lys Asp Phe
         115                 120                 125            
 Pro Pro Gly Ala Glu Pro Ser Thr Ser Gly Thr Thr Asp Glu Glu Leu
     130                 135                 140                
 Glu Glu Leu Arg Pro Leu Pro Glu Glu Gly Glu Glu Arg Arg Arg Leu
 145                 150                 155                 160
 Gly Ala Glu Pro Thr Val Arg Pro Arg Gly Arg Ser Met Gln Ala Leu
                 165                 170                 175    
 Ala Glu Glu Asp Leu Gln His Leu Pro Pro Gln Pro Leu Pro Pro Gln
             180                 185                 190        
 Leu Ser Gln Ala Asp Gly Arg Ser Glu Thr Ser Gln Pro Pro Thr Pro
         195                 200                 205            
 Gly Ser Pro Ser His Ser Pro Leu His Ser Gly Pro Arg Pro Arg Arg
     210                 215                 220                
 Arg Glu Ser Asp Pro Thr Gly Pro Gln Arg Gln Leu Glu Glu Asp Arg
 225                 230                 235                 240
 Leu Ser Gly His Ser Leu Pro Arg Tyr Ser Pro Leu Arg Arg Leu Ala
                 245                 250                 255    
 Ser Ser Val Phe Ser Ser Ser Thr Leu Glu Thr Glu His Tyr Pro His
             260                 265                 270        
 Pro Gly Gly Gly Gly Ser Ser Gly Ser Ser Gly Ser Leu Ile Gln Arg
         275                 280                 285            
 Ser Arg Ser Ala Glu Ser Ser Pro Val Arg Ala Pro His Arg Arg His
     290                 295                 300                
 Ala Pro Leu Ala Ala Gly Asn His Arg Leu Met Pro Ser Val Leu Arg
 305                 310                 315                 320
 Ile Ser Arg Ser Gln Leu Gln Gln Val Trp Ala Arg Phe Thr His Lys
                 325                 330                 335    
 Thr
    



      <210> 804
      <211> 178
      <212> PRT
      <213> Homo sapiens


      <400> 804
 Met Glu Leu Ser Glu Ser Val Gln Lys Gly Phe Gln Met Leu Ala Asp
   1               5                  10                  15    
 Pro Arg Ser Phe Asp Ser Asn Ala Phe Thr Leu Leu Leu Arg Ala Ala
              20                  25                  30        
 Phe Gln Ser Leu Leu Asp Ala Gln Ala Asp Glu Ala Val Leu Gly Lys
          35                  40                  45            
 Pro Leu Gly Ser Ala Arg Ser Trp Ile Arg Arg Gly Gly Gly Ala Leu
      50                  55                  60                
 Gly Glu Glu Glu Pro Ala Glu Arg Glu Gly Glu Ser Pro Gly Lys Arg
  65                  70                  75                  80
 Lys Ser Pro Gly Phe Ala Leu Arg Ser Gly Arg Ser Val Gly Asp Val
                  85                  90                  95    
 Ala Leu Pro Gly Leu Gly Ala Asp Ser Glu His Cys Phe Gly Pro Thr
             100                 105                 110        
 Trp His Leu His Arg Ala Asn Ser Thr Phe Leu Ala Arg Phe Pro Ser
         115                 120                 125            
 Gln Ser Leu Cys Ser Phe Val Lys Pro Val Phe Lys Ser Cys Leu Trp
     130                 135                 140                
 Pro Lys His Leu Arg Cys Leu Ala Leu Ser Glu Ala Ala Ala Val Leu
 145                 150                 155                 160
 Thr Val Gly Leu His Leu Gly Ser Ser Leu Gln Phe Lys Leu Pro Gly
                 165                 170                 175    
 Leu Gly
        



      <210> 805
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 805
 Met Trp Arg Ala Lys Leu Arg Arg Gly Thr Cys Glu Pro Ala Val Lys
   1               5                  10                  15    
 Gly Ser Pro Ser Ala Cys Tyr Ser Pro Ser Ser Pro Val Gln Val Leu
              20                  25                  30        
 Glu Asp Ser Thr Tyr Phe Ser Pro Asp Phe Gln Leu Tyr Ser Gly Arg
          35                  40                  45            
 His Glu Thr Ser Ala Leu Thr Val Glu Ala Thr Ser Ser Ile Arg Glu
      50                  55                  60                
 Lys Val Val Glu Asp Pro Leu Cys Asn Phe His Ser Pro Asn Phe Leu
  65                  70                  75                  80
 Arg Ile Ser Glu Val Glu Met Arg Gly Ser Glu Asp Ala Ala Ala Gly
                  85                  90                  95    
 Thr Val Leu Gln Arg Leu Ile Gln Glu Gln Leu Arg Tyr Gly Thr Pro
             100                 105                 110        
 Thr Glu Asn Met Asn Leu Leu Ala Ile Gln His Gln Ala Thr Gly Ser
         115                 120                 125            
 Ala Gly Pro Ala His Pro Thr Asn Asn Phe Ser Ser Thr Glu Asn Leu
     130                 135                 140                
 Thr Gln Glu Asp Pro Gln Met Val Tyr Gln Ser Ala Arg Gln Glu Pro
 145                 150                 155                 160
 Gln Gly Gln Glu His Arg Leu Ala Ile Arg
                 165                 170



      <210> 806
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 806
 Met Gln Leu Thr Glu Arg Glu Arg Gln Pro Val Leu Pro Ser Leu Ser
   1               5                  10                  15    
 Leu Gly Ile Ser Ser His Gln Gly Pro Ala Phe Arg Thr Ser Asn Asn
              20                  25                  30        
 Pro Ser Leu Leu Pro Cys His Ser Leu Pro Glu Arg Lys Glu Lys Glu
          35                  40                  45            
 Arg Glu Arg Phe Trp Asn Leu Asn Leu Pro Lys Glu Glu Thr Tyr Pro
      50                  55                  60                
 Ala Asn Ser Val Asp
  65                



      <210> 807
      <211> 764
      <212> PRT
      <213> Homo sapiens


      <400> 807
 Met Val Ala Met Ala Glu Ala Glu Ala Gly Val Ala Val Glu Val Arg
   1               5                  10                  15    
 Gly Leu Pro Pro Ala Val Pro Asp Glu Leu Leu Thr Leu Tyr Phe Glu
              20                  25                  30        
 Asn Arg Arg Arg Ser Gly Gly Gly Pro Val Leu Ser Trp Gln Arg Leu
          35                  40                  45            
 Gly Cys Gly Gly Val Leu Thr Phe Arg Glu Pro Ala Asp Ala Glu Arg
      50                  55                  60                
 Val Leu Ala Gln Ala Asp His Glu Leu His Gly Ala Gln Leu Ser Leu
  65                  70                  75                  80
 Arg Pro Ala Pro Pro Arg Ala Pro Ala Arg Leu Leu Leu Gln Gly Leu
                  85                  90                  95    
 Pro Pro Gly Thr Thr Pro Gln Arg Leu Glu Gln His Val Gln Ala Leu
             100                 105                 110        
 Leu Arg Ala Ser Gly Leu Pro Val Gln Pro Cys Cys Ala Leu Ala Ser
         115                 120                 125            
 Pro Arg Pro Asp Arg Ala Leu Val Gln Leu Pro Lys Pro Leu Ser Glu
     130                 135                 140                
 Ala Asp Val Arg Val Leu Glu Glu Gln Ala Gln Asn Leu Gly Leu Glu
 145                 150                 155                 160
 Gly Thr Leu Val Ser Leu Ala Arg Val Pro Gln Ala Arg Ala Val Arg
                 165                 170                 175    
 Val Val Gly Asp Gly Ala Ser Val Asp Leu Leu Leu Leu Glu Leu Tyr
             180                 185                 190        
 Leu Glu Asn Glu Arg Arg Ser Gly Gly Gly Pro Leu Glu Asp Leu Gln
         195                 200                 205            
 Arg Leu Pro Gly Pro Leu Gly Thr Val Ala Ser Phe Gln Gln Trp Gln
     210                 215                 220                
 Val Ala Glu Arg Val Leu Gln Gln Glu His Arg Leu Gln Gly Ser Glu
 225                 230                 235                 240
 Leu Ser Leu Val Pro His Tyr Asp Ile Leu Glu Pro Glu Glu Leu Ala
                 245                 250                 255    
 Glu Asn Thr Ser Gly Gly Asp His Pro Ser Thr Gln Gly Pro Arg Ala
             260                 265                 270        
 Thr Lys His Ala Leu Leu Arg Thr Gly Gly Leu Val Thr Ala Leu Gln
         275                 280                 285            
 Gly Ala Gly Thr Val Thr Met Gly Ser Gly Glu Glu Pro Gly Gln Ser
     290                 295                 300                
 Gly Ala Ser Leu Arg Thr Gly Pro Met Val Gln Gly Arg Gly Ile Met
 305                 310                 315                 320
 Thr Thr Gly Ser Gly Gln Glu Pro Gly Gln Ser Gly Thr Ser Leu Arg
                 325                 330                 335    
 Thr Gly Pro Met Gly Ser Leu Gly Gln Ala Glu Gln Val Ser Ser Met
             340                 345                 350        
 Pro Met Gly Ser Leu Glu His Glu Gly Leu Val Ser Leu Arg Pro Val
         355                 360                 365            
 Gly Leu Gln Glu Gln Glu Gly Pro Met Ser Leu Gly Pro Val Gly Ser
     370                 375                 380                
 Ala Gly Pro Val Glu Thr Ser Lys Gly Leu Leu Gly Gln Glu Gly Leu
 385                 390                 395                 400
 Val Glu Ile Ala Met Asp Ser Pro Glu Gln Glu Gly Leu Val Gly Pro
                 405                 410                 415    
 Met Glu Ile Thr Met Gly Ser Leu Glu Lys Ala Gly Pro Val Ser Pro
             420                 425                 430        
 Gly Cys Val Lys Leu Ala Gly Gln Glu Gly Leu Val Glu Met Val Leu
         435                 440                 445            
 Leu Met Glu Pro Gly Ala Met Arg Phe Leu Gln Leu Tyr His Glu Asp
     450                 455                 460                
 Leu Leu Ala Gly Leu Gly Asp Val Ala Leu Leu Pro Leu Glu Gly Pro
 465                 470                 475                 480
 Asp Met Thr Gly Phe Arg Leu Cys Gly Ala Gln Ala Ser Cys Gln Ala
                 485                 490                 495    
 Ala Glu Glu Phe Leu Arg Ser Leu Leu Gly Ser Ile Ser Cys His Val
             500                 505                 510        
 Leu Cys Leu Glu His Pro Gly Ser Ala Arg Phe Leu Leu Gly Pro Glu
         515                 520                 525            
 Gly Gln His Leu Leu Gln Gly Leu Glu Ala Gln Phe Gln Cys Val Phe
     530                 535                 540                
 Gly Thr Glu Arg Leu Ala Thr Ala Thr Leu Asp Thr Gly Leu Glu Glu
 545                 550                 555                 560
 Val Asp Pro Thr Glu Ala Leu Pro Val Leu Pro Gly Asn Ala His Thr
                 565                 570                 575    
 Leu Trp Thr Pro Asp Ser Thr Gly Gly Asp Gln Glu Asp Val Ser Leu
             580                 585                 590        
 Glu Glu Val Arg Glu Leu Leu Ala Thr Leu Glu Gly Leu Asp Leu Asp
         595                 600                 605            
 Gly Glu Asp Trp Leu Pro Arg Glu Leu Glu Glu Glu Gly Pro Gln Glu
     610                 615                 620                
 Gln Pro Glu Glu Glu Val Thr Pro Gly His Glu Glu Glu Glu Pro Val
 625                 630                 635                 640
 Ala Pro Ser Thr Val Ala Pro Arg Trp Leu Glu Glu Glu Ala Ala Leu
                 645                 650                 655    
 Gln Leu Ala Leu His Arg Ser Leu Glu Pro Gln Gly Gln Val Ala Glu
             660                 665                 670        
 Gln Glu Glu Ala Ala Ala Leu Arg Gln Ala Leu Thr Leu Ser Leu Leu
         675                 680                 685            
 Glu Gln Pro Pro Leu Glu Ala Glu Glu Pro Pro Asp Gly Gly Thr Asp
     690                 695                 700                
 Gly Lys Ala Gln Leu Val Val His Ser Ala Phe Glu Gln Asp Val Glu
 705                 710                 715                 720
 Glu Leu Asp Arg Ala Leu Arg Ala Ala Leu Glu Val His Val Gln Glu
                 725                 730                 735    
 Glu Thr Val Gly Pro Trp Arg Arg Thr Leu Pro Ala Glu Leu Arg Ala
             740                 745                 750        
 Arg Leu Glu Arg Cys His Gly Trp Arg Gly Arg Arg
         755                 760                



      <210> 808
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 808
 Met Gly Gly Cys Pro Val Arg Lys Arg Arg Arg Asn Gly Ser Lys Glu
   1               5                  10                  15    
 Gly Asn His His Ser Thr Gln Pro Lys Arg Asn Lys Arg Asn Pro Ile
              20                  25                  30        
 Phe Gln Asp Ser Gln Asp Thr Glu Phe Ser Trp Ser Asp Asn Glu Arg
          35                  40                  45            
 Ser Ser Ser Arg Ile Asn Ile Pro Glu Arg Ala Ser Gly Pro Glu Gly
      50                  55                  60                
 Asn Leu Asn Gln Ile Val Thr Glu Pro Asp Ala Asn Phe Pro Gln Phe
  65                  70                  75                  80
 Leu His Glu Gly Leu Ser Lys Pro Val Tyr Val Ile Asn Trp Phe Met
                  85                  90                  95    
 Ser Phe Gly Pro Glu Ile Lys Leu Asn Thr Ser Gln Gln Gly Arg Asn
             100                 105                 110        
 Gln Ala Val
         115



      <210> 809
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 809
 Met Ala Gly Met Lys Thr Ala Ser Gly Asp Tyr Ile Asp Ser Ser Trp
   1               5                  10                  15    
 Glu Leu Arg Val Phe Val Gly Glu Glu Asp Pro Glu Ala Glu Ser Val
              20                  25                  30        
 Thr Leu Arg Val Thr Gly Glu Ser His Ile Gly Gly Val Leu Leu Lys
          35                  40                  45            
 Ile Val Glu Gln Ile Asn Arg Lys Gln Asp Trp Ser Asp His Ala Ile
      50                  55                  60                
 Trp Trp Glu Gln Lys Arg Gln Trp Leu Leu Gln Thr His Trp Thr Leu
  65                  70                  75                  80
 Asp Lys Tyr Gly Ile Leu Ala Asp Ala Arg Leu Phe Phe Gly Pro Gln
                  85                  90                  95    
 His Arg Pro Val Ile Leu Arg Leu Pro Asn Arg Arg Ala Leu Arg Leu
             100                 105                 110        
 Arg Ala Ser Phe Ser Gln Pro Leu Phe Gln Ala Val Ala Ala Ile Cys
         115                 120                 125            
 Arg Leu Leu Ser Ile Arg His Pro Glu Glu Leu Ser Leu Leu Arg Ala
     130                 135                 140                
 Pro Glu Lys Lys Glu Lys Lys Lys Lys Glu Lys Glu Pro Glu Glu Glu
 145                 150                 155                 160
 Leu Tyr Asp Leu Ser Lys Val Val Leu Ala Gly Gly Val Ala Pro Ala
                 165                 170                 175    
 Leu Phe Arg Gly Met Ser
             180        



      <210> 810
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 810
 Met Asp Thr Gly Ile Thr Gln Thr Pro Lys Tyr Leu Val Thr Ala Met
   1               5                  10                  15    
 Gly Ser Lys Arg Thr Met Lys Arg Glu His Leu Gly His Asp Ser Met
              20                  25                  30        
 Tyr Trp Tyr Arg Gln Lys Ala Lys Lys Ser Leu Glu Phe Met Phe Tyr
          35                  40                  45            
 Tyr Asn Cys Lys Glu Phe Ile Glu Asn Lys Thr Val Pro Asn His Phe
      50                  55                  60                
 Thr Pro Glu Cys Pro Asp Ser Ser Arg Leu Tyr Leu His Val Val Ala
  65                  70                  75                  80
 Leu Gln Gln Glu Asp Ser Ala Ala Tyr Leu Cys Thr Ser Ser Gln Asp
                  85                  90                  95    
 Thr Ala Leu Gln Ser His Arg Leu Pro Val His Lys Pro Pro Gly Ser
             100                 105                 110        
 Asn Gln Lys Thr Val Gly Ala Thr His Pro Ala Glu Pro Gln His Ser
         115                 120                 125            
 Val Gln His Ser Val Arg Pro Gln Gln Thr Ser Gln Ile Ile Ile Leu
     130                 135                 140                
 Ser Phe Ile Gly Cys Gly Asn Ala Lys Leu Pro Arg Leu Leu Gln Pro
 145                 150                 155                 160
 Val Ala
        



      <210> 811
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 811
 Met Thr Pro Gly Gly Leu Phe Leu Pro Tyr His Ser Leu Pro Gln Pro
   1               5                  10                  15    
 Asp Phe Leu Ala Ser Cys Pro Thr Arg His Leu Lys Leu Cys Gln Arg
              20                  25                  30        
 Pro Gly Ile Leu Ala Glu Asn Pro His Gln Phe Ser Pro Thr Phe Pro
          35                  40                  45            
 Pro Gly Lys Gly Ser Cys Gln His Gly Ala Leu Pro Gly Gln Val Ser
      50                  55                  60                
 Leu Lys Glu Ala Ala His Thr Glu Met Ser Leu Ser Gly Gln Asp Leu
  65                  70                  75                  80
 Phe Pro Ser Pro Ala His Pro Pro Leu Gln Pro Phe Trp Leu Pro Phe
                  85                  90                  95    
 Ser Leu Cys Leu Ser Thr Pro Phe Leu Val Ala Asp Asn Glu Leu Arg
             100                 105                 110        
 Leu Pro Lys Gly Gln Ile Cys Pro Leu His Val Phe Val Leu Ala Asn
         115                 120                 125            
 Arg Val Val Leu Lys Leu Cys Ala Asn Ser Val Trp Glu His Ser Lys
     130                 135                 140                
 Gly Ile Thr
 145        



      <210> 812
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 812
 Met Glu Arg Ser Pro Ser Arg Arg Arg Arg Leu Glu Glu Ala Pro Lys
   1               5                  10                  15    
 Leu Pro Tyr Lys Asn Pro Thr His Leu Ala Gln Gln Gln Glu Pro Trp
              20                  25                  30        
 Ser Arg Leu Asn Ser Thr Pro Thr Ile Thr Ser Met Arg Arg Asp Ala
          35                  40                  45            
 Tyr Tyr Phe Asp Pro Glu Ile Pro Lys Asp Asp Leu Asp Phe Arg Leu
      50                  55                  60                
 Ala Ala Leu Tyr Asn His His Thr Gly Thr Phe Lys Asn Lys Ser Glu
  65                  70                  75                  80
 Ile Leu Leu Asn Gln Lys Thr Thr Gln Asp Thr Tyr Arg Thr Lys Ile
                  85                  90                  95    
 Gln Phe Pro Gly Glu Phe Leu Thr Pro Pro Thr Pro Pro Ile Thr Phe
             100                 105                 110        
 Leu Ala Asn Ile Arg His Trp Ile Asn Pro Lys Lys Glu Ser Ile His
         115                 120                 125            
 Ser Ile Gln Gly Ser Ile Val Ser Pro His Thr Ala Ala Thr Asn Gly
     130                 135                 140                
 Gly Tyr Ser Arg Lys Lys Asp Gly Gly Phe Phe Ser Thr
 145                 150                 155        



      <210> 813
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 813
 Met Ala Arg Ala Ser Ser Gly Asn Gly Ser Glu Glu Ala Trp Gly Ala
   1               5                  10                  15    
 Leu Arg Ala Pro Gln Gln Gln Leu Arg Glu Leu Cys Pro Gly Val Asn
              20                  25                  30        
 Asn Gln Pro Tyr Leu Cys Glu Ser Gly His Cys Cys Gly Glu Thr Gly
          35                  40                  45            
 Cys Cys Thr Tyr Tyr Tyr Glu Leu Trp Trp Phe Trp Leu Leu Trp Thr
      50                  55                  60                
 Val Leu Ile Leu Phe Ser Cys Cys Cys Ala Phe Arg His Arg Arg Ala
  65                  70                  75                  80
 Lys Leu Arg Leu Gln Gln Gln Gln Arg Gln Arg Glu Ile Asn Leu Leu
                  85                  90                  95    
 Ala Tyr His Gly Ala Cys His Gly Ala Gly Pro Phe Pro Thr Gly Ser
             100                 105                 110        
 Leu Leu Asp Leu Arg Phe Leu Ser Thr Phe Lys Pro Pro Ala Tyr Glu
         115                 120                 125            
 Asp Val Val His Arg Pro Gly Thr Pro Pro Pro Pro Tyr Thr Val Ala
     130                 135                 140                
 Pro Gly Arg Pro Leu Thr Ala Ser Ser Glu Gln Thr Cys Cys Ser Ser
 145                 150                 155                 160
 Ser Ser Ser Cys Pro Ala His Phe Glu Gly Thr Asn Val Glu Gly Val
                 165                 170                 175    
 Ser Ser His Gln Ser Ala Pro Pro His Gln Glu Gly Glu Pro Gly Ala
             180                 185                 190        
 Gly Val Thr Pro Ala Ser Thr Pro Pro Ser Cys Arg Tyr Arg Arg Leu
         195                 200                 205            
 Thr Gly Asp Ser Gly Ile Glu Leu Cys Pro Cys Pro Ala Ser Gly Glu
     210                 215                 220                
 Gly Glu Pro Val Lys Glu Val Arg Val Ser Ala Thr Leu Pro Asp Leu
 225                 230                 235                 240
 Glu Asp Tyr Ser Pro Val Cys Thr Thr Pro Arg Val Cys Thr Ala Asp
                 245                 250                 255    
 Leu Ser His Gly Ala Val Phe Gln
             260                



      <210> 814
      <211> 360
      <212> PRT
      <213> Homo sapiens


      <400> 814
 Met Ser Gly Ser Val Leu Phe Thr Ala Gly Glu Arg Trp Arg Cys Phe
   1               5                  10                  15    
 Leu Thr Pro Ser Arg Ser Ser Leu Tyr Trp Ala Leu His Asn Phe Cys
              20                  25                  30        
 Cys Arg Lys Lys Ser Thr Thr Pro Lys Lys Ile Thr Pro Asn Val Thr
          35                  40                  45            
 Phe Cys Asp Glu Asn Ala Lys Glu Pro Glu Asn Ala Leu Asp Lys Leu
      50                  55                  60                
 Phe Ser Ser Glu Gln Gln Ala Ser Ile Leu His Val Leu Asn Thr Ala
  65                  70                  75                  80
 Ser Thr Lys Glu Leu Glu Ala Phe Arg Leu Leu Arg Gly Arg Arg Ser
                  85                  90                  95    
 Ile Asn Ile Val Glu His Arg Glu Asn Phe Gly Pro Phe Gln Asn Leu
             100                 105                 110        
 Glu Ser Leu Met Asn Val Pro Leu Phe Lys Tyr Lys Ser Thr Val Gln
         115                 120                 125            
 Val Cys Asn Ser Ile Leu Cys Pro Lys Thr Gly Arg Glu Lys Arg Lys
     130                 135                 140                
 Ser Pro Glu Asn Arg Phe Leu Arg Lys Leu Leu Lys Pro Asp Ile Glu
 145                 150                 155                 160
 Arg Glu Arg Leu Lys Ala Val Asn Ser Ile Ile Ser Ile Val Phe Gly
                 165                 170                 175    
 Thr Arg Arg Ile Ala Trp Ala His Leu Asp Arg Lys Leu Thr Val Leu
             180                 185                 190        
 Asp Trp Gln Gln Ser Asp Arg Trp Ser Leu Met Arg Gly Ile Tyr Ser
         195                 200                 205            
 Ser Ser Val Tyr Leu Glu Glu Ile Ser Ser Ile Ile Ser Lys Met Pro
     210                 215                 220                
 Lys Ala Asp Phe Tyr Val Leu Glu Lys Thr Gly Leu Ser Ile Gln Asn
 225                 230                 235                 240
 Ser Ser Leu Phe Pro Ile Leu Leu His Phe His Ile Met Glu Ala Met
                 245                 250                 255    
 Leu Tyr Ala Leu Leu Asn Lys Thr Phe Ala Gln Asp Gly Gln His Gln
             260                 265                 270        
 Val Leu Ser Met Asn Arg Asn Ala Val Gly Lys His Phe Glu Leu Met
         275                 280                 285            
 Ile Gly Asp Ser Arg Thr Ser Gly Lys Glu Leu Val Lys Gln Phe Leu
     290                 295                 300                
 Phe Asp Ser Ile Leu Lys Ala Asp Pro Arg Val Phe Phe Pro Ser Asp
 305                 310                 315                 320
 Lys Ile Val His Tyr Arg Gln Met Phe Leu Ser Thr Glu Leu Gln Arg
                 325                 330                 335    
 Val Glu Glu Leu Tyr Asp Ser Leu Leu Gln Ala Ile Ala Phe Tyr Glu
             340                 345                 350        
 Leu Ala Val Phe Asp Ser Gln Pro
         355                 360



      <210> 815
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 815
 Met Gln Val Lys Ile Thr Ser Pro Gly Leu Phe Arg Ile Val Tyr Ile
   1               5                  10                  15    
 Ala Glu Arg His Asn Cys Gln Tyr Pro Glu Asn Ile Leu Ser Phe Ile
              20                  25                  30        
 Lys Cys Val Ile His Asn Phe Trp Ile Pro Lys Glu Ser Asn Glu Ile
          35                  40                  45            
 Thr Ile Ile Ile Asn Pro Tyr Arg Glu Thr Val Cys Phe Ser Val Glu
      50                  55                  60                
 Pro Val Lys Lys Thr Leu Gln Tyr Ser Ser Tyr Ser Ser Ser Val
  65                  70                  75                



      <210> 816
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 816
 Met Glu Glu Glu Gly Gly Gly Arg Ser Cys Gly Thr Thr Arg Glu Leu
   1               5                  10                  15    
 Gln Lys Leu Lys Gln Gln Ala Met Glu Tyr Tyr Arg Glu Asn Asp Val
              20                  25                  30        
 Pro Arg Arg Leu Glu Glu Leu Leu Asn Ser Thr Phe Tyr Leu Gln Pro
          35                  40                  45            
 Ala Asp Val Tyr Gly His Leu Val Gly Thr Trp Asp Lys Arg Ser Pro
      50                  55                  60                
 Pro Ala Asn Pro Ser Pro Pro Ala Pro Arg Cys Gly Asn Ala Leu Arg
  65                  70                  75                  80
 Leu Arg Leu Arg Leu Arg Ile Ser His Ala Ser Arg Pro Gly Pro Gly
                  85                  90                  95    
 Pro Ala Cys Ala Glu Glu Thr Ser Gly Gly Lys Glu Arg Glu Gly His
             100                 105                 110        
 Pro Gly Val Lys Gly Ser Pro Gln Arg Lys Trp Gln Lys Gly Gly Ser
         115                 120                 125            
 Trp Arg Lys Glu Gly Ala Arg Arg Ile
     130                 135        



      <210> 817
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 817
 Met Ala Lys Gly Leu Arg Val Asn Leu Gly Glu Leu Val Glu Ser Met
   1               5                  10                  15    
 Arg Leu Cys Phe Leu Ser Val His Phe Arg Leu Arg Trp Gly Asp Ser
              20                  25                  30        
 Cys Pro Ser Ser Pro His Arg Glu Thr Phe Pro Ala Gly Pro Val Asn
          35                  40                  45            
 Gly Pro Leu Tyr His Pro His Pro Glu
      50                  55        



      <210> 818
      <211> 77
      <212> PRT
      <213> Homo sapiens


      <400> 818
 Met Gly Trp Ser Gln Asp Leu Phe Arg Ala Leu Trp Arg Ser Leu Ser
   1               5                  10                  15    
 Arg Glu Val Lys Glu His Val Gly Thr Asp Gln Phe Gly Asn Lys Tyr
              20                  25                  30        
 Tyr Tyr Ile Pro Gln Tyr Lys Asn Trp Arg Gly Gln Thr Ile Arg Glu
          35                  40                  45            
 Lys Arg Ile Val Glu Ala Ala Asn Lys Lys Glu Val Asp Tyr Glu Ala
      50                  55                  60                
 Gly Asp Ile Pro Thr Glu Trp Glu Gly Asn Thr Lys Glu
  65                  70                  75        



      <210> 819
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 819
 Met Glu Ser Tyr Phe Phe Lys Glu Thr Ser His Glu Ser Val Asp Ser
   1               5                  10                  15    
 Ser Lys Glu Glu Pro Gln Thr Leu Pro Glu Thr Gln Asp Gly Asp Leu
              20                  25                  30        
 His Leu Gln Glu Gln Gly Ser Gly Ile Asp Trp Cys Leu Ser Pro Ala
          35                  40                  45            
 Asp Val Glu Ala Gln Thr Thr Asn Asp Gln Lys Gly Asn Ile Pro Asp
      50                  55                  60                
 Glu Ser Gln Val Glu Lys Leu Asn Val Phe Leu Ser Pro Pro Asp Val
  65                  70                  75                  80
 Ile Asn Tyr Leu Ala Leu Thr Glu Ala Thr Gly Arg Ile Cys Val Ser
                  85                  90                  95    
 Gln Trp Glu Gly Pro Pro Arg Leu Gly Cys Ile Phe Cys His Gly Asp
             100                 105                 110        
 His Leu Leu Ala Val Asn Asp Leu Lys Pro Gln Ser Leu Glu Glu Val
         115                 120                 125            
 Ser Leu Phe Leu Thr Arg Ser Ile Gln Lys Glu Lys Leu Lys Leu Thr
     130                 135                 140                
 Ile Gly Arg Ile Pro Asn Ser Glu Thr Phe His Ala Ala Ser Cys Met
 145                 150                 155                 160
 Cys Pro Ser Lys Cys Gln Ser Ala Ala Pro Ser Gln Leu Asp Lys Pro
                 165                 170                 175    
 Arg Leu Asn Arg Ala Pro Lys Arg Ser Pro Ala Ile Lys Lys Ser Gln
             180                 185                 190        
 Gln Lys Gly Ala Arg Glu
         195            



      <210> 820
      <211> 333
      <212> PRT
      <213> Homo sapiens


      <400> 820
 Met Gly Glu Pro Gly Pro Pro Ser Pro Pro Ala Pro Lys Ala Ala Pro
   1               5                  10                  15    
 Gly Leu Ile Asp Ser Phe Ser Glu Met Asn Asn Tyr Arg Arg Ala Met
              20                  25                  30        
 Gln Lys Met Ala Glu Asp Ile Leu Ser Leu Arg Arg Gln Ala Ser Ile
          35                  40                  45            
 Leu Glu Gly Glu Asn Arg Ile Leu Arg Ser Arg Leu Ala Gln Gln Glu
      50                  55                  60                
 Glu Glu Glu Gly Gln Gly Lys Ala Ser Glu Ala Gln Asn Thr Val Ser
  65                  70                  75                  80
 Met Lys Gln Lys Leu Leu Leu Ser Glu Leu Asp Met Lys Lys Leu Arg
                  85                  90                  95    
 Asp Arg Val Gln His Leu Gln Asn Glu Leu Ile Arg Lys Asn Asp Arg
             100                 105                 110        
 Glu Lys Glu Leu Leu Leu Leu Tyr Gln Ala Gln Gln Pro Gln Ala Ala
         115                 120                 125            
 Leu Leu Lys Gln Tyr Gln Gly Lys Leu Gln Lys Met Lys Ala Leu Glu
     130                 135                 140                
 Glu Thr Val Arg His Gln Glu Lys Val Ile Glu Lys Met Glu Arg Val
 145                 150                 155                 160
 Leu Glu Asp Arg Leu Gln Asp Arg Ser Lys Pro Pro Pro Leu Asn Arg
                 165                 170                 175    
 Gln Gln Gly Lys Pro Tyr Thr Gly Phe Pro Met Leu Ser Ala Ser Gly
             180                 185                 190        
 Leu Pro Leu Gly Ser Met Gly Glu Asn Leu Pro Val Glu Leu Tyr Ser
         195                 200                 205            
 Val Leu Leu Ala Glu Asn Ala Lys Leu Arg Thr Glu Leu Asp Lys Asn
     210                 215                 220                
 Arg His Gln Gln Ala Pro Ile Ile Leu Gln Gln Gln Ala Leu Pro Asp
 225                 230                 235                 240
 Leu Leu Ser Gly Thr Ser Asp Lys Phe Asn Leu Leu Ala Lys Leu Glu
                 245                 250                 255    
 His Ala Gln Ser Arg Ile Leu Ser Leu Glu Ser Gln Leu Glu Asp Ser
             260                 265                 270        
 Ala Arg Arg Trp Gly Arg Glu Lys Gln Asp Leu Ala Thr Arg Leu Gln
         275                 280                 285            
 Glu Gln Glu Lys Gly Phe Arg His Pro Ser Asn Ser Ile Ile Ile Glu
     290                 295                 300                
 Gln Pro Val Ser Asp Pro Pro Gly Val Ala Pro Arg Gly Ser Gly Gly
 305                 310                 315                 320
 Gly Ala Gly Ser His Arg Thr Pro Lys Val Thr Gly Pro
                 325                 330            



      <210> 821
      <211> 290
      <212> PRT
      <213> Homo sapiens


      <400> 821
 Met Trp Met His Val Ala Lys Val His Pro Lys Gly Gly Glu Met Val
   1               5                  10                  15    
 Gly Ala Ile Arg Asn Ala Ala Phe Leu Ala Lys Pro Ser Ile Pro Gln
              20                  25                  30        
 Val Pro Asn Tyr Arg Leu Ser Met Thr Ile Pro Asp Trp Leu Gln Ala
          35                  40                  45            
 Ile Gln Asn Tyr Met Lys Thr Leu Gln Tyr Asn His Thr Gly Thr Gln
      50                  55                  60                
 Phe Phe Glu Ile Arg Lys Met Arg Pro Leu Ser Gly Leu Met Glu Thr
  65                  70                  75                  80
 Ala Lys Glu Met Thr Arg Glu Ser Leu Pro Ile Lys Cys Leu Glu Ala
                  85                  90                  95    
 Val Ile Leu Gly Ile Tyr Leu Thr Asn Gly Gln Pro Ser Ile Glu Arg
             100                 105                 110        
 Phe Pro Ile Ser Phe Lys Thr Tyr Phe Ser Gly Asn Tyr Phe His His
         115                 120                 125            
 Val Val Leu Gly Ile Tyr Cys Asn Gly Arg Tyr Gly Ser Leu Gly Met
     130                 135                 140                
 Ser Arg Arg Ala Glu Leu Met Asp Lys Pro Leu Thr Phe Arg Thr Leu
 145                 150                 155                 160
 Ser Asp Leu Ile Phe Asp Phe Glu Asp Ser Tyr Lys Lys Tyr Leu His
                 165                 170                 175    
 Thr Val Lys Lys Val Lys Ile Gly Leu Tyr Val Pro His Glu Pro His
             180                 185                 190        
 Ser Phe Gln Pro Ile Glu Trp Lys Gln Leu Val Leu Asn Val Ser Lys
         195                 200                 205            
 Met Leu Arg Ala Asp Ile Arg Lys Glu Leu Glu Lys Tyr Ala Arg Asp
     210                 215                 220                
 Met Arg Met Lys Ile Leu Lys Pro Ala Ser Ala His Ser Pro Thr Gln
 225                 230                 235                 240
 Val Arg Ser Arg Gly Lys Ser Leu Ser Pro Arg Arg Arg Gln Ala Ser
                 245                 250                 255    
 Pro Pro Arg Arg Leu Gly Arg Arg Glu Lys Ser Pro Ala Leu Pro Glu
             260                 265                 270        
 Lys Lys Val Ala Asp Leu Ser Thr Leu Asn Glu Val Gly Tyr Gln Ile
         275                 280                 285            
 Arg Ile
     290



      <210> 822
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 822
 Met Ser Tyr Asn Cys Cys Ser Gly Asn Phe Ser Ser Arg Ser Cys Gly
   1               5                  10                  15    
 Asp Tyr Leu Arg Tyr Pro Ala Ser Ser Arg Gly Phe Ser Tyr Pro Ser
              20                  25                  30        
 Asn Leu Val Tyr Ser Thr Asp Leu Cys Ser Pro Ser Thr Cys Gln Leu
          35                  40                  45            
 Gly Ser Ser Leu Tyr Arg Gly Cys Gln Glu Ile Cys Trp Glu Pro Thr
      50                  55                  60                
 Ser Cys Gln Thr Ser Tyr Val Glu Ser Ser Pro Cys Gln Thr Ser Cys
  65                  70                  75                  80
 Tyr Arg Pro Arg Thr Ser Leu Leu Cys Ser Pro Cys Lys Thr Thr Tyr
                  85                  90                  95    
 Ser Gly Ser Leu Gly Phe Gly Ser Ser Ser Cys Arg Ser Leu Gly Tyr
             100                 105                 110        
 Gly Ser Arg Ser Cys Tyr Ser Val Gly Cys Gly Ser Ser Gly Val Arg
         115                 120                 125            
 Ser Leu Gly Tyr Gly Ser Cys Gly Phe Pro Ser Leu Gly Tyr Gly Ser
     130                 135                 140                
 Gly Phe Cys Arg Pro Thr Tyr Leu Ala Ser Arg Ser Cys Gln Ser Pro
 145                 150                 155                 160
 Cys Tyr Arg Pro Ala Tyr Gly Ser Thr Phe Cys Arg Ser Thr Cys
                 165                 170                 175



      <210> 823
      <211> 143
      <212> PRT
      <213> Homo sapiens


      <400> 823
 Met Trp Ile Met Thr Arg Thr Trp Gly Gly Gln Ala Arg Val Asn Gly
   1               5                  10                  15    
 Lys Ile Lys Ala Pro Ala Arg Ala Gly Arg Thr Val Ser Ser Cys Ile
              20                  25                  30        
 Phe Ser Ser Cys Leu Trp Phe Leu Pro Phe Arg Ser Ser Cys Leu Lys
          35                  40                  45            
 Thr Gln Pro Asp Ser Asp Ala Cys Gln Pro Ala Ser Pro Thr Arg Ala
      50                  55                  60                
 Ala Ala Leu Pro Thr Arg Met Gly Gly Thr Thr Pro Pro Arg Cys Pro
  65                  70                  75                  80
 Arg Ala Glu Arg Ser Arg Gly Ser Thr Gly Ile Ala Arg Ala Ser Ala
                  85                  90                  95    
 Leu Ala Ala Gly Gly Ala Gly Val Leu Arg Gly Arg Asp Gln Ser Ala
             100                 105                 110        
 Ile Arg Ala Ala Thr Pro Asp Leu Gly Arg Gln Leu Ser Ser His Cys
         115                 120                 125            
 Asp Gly His Trp Gly Ala Pro Ser Ile Leu Val Lys Phe Ser Leu
     130                 135                 140            



      <210> 824
      <211> 303
      <212> PRT
      <213> Homo sapiens


      <400> 824
 Met Pro Pro Met Ala Val Ala Leu Lys Pro Val Leu Gln Gln Ser Arg
   1               5                  10                  15    
 Glu Ala Arg Asp Glu Leu Pro Gly Ala Pro Pro Val Leu Cys Ser Ser
              20                  25                  30        
 Ser Ser Asp Leu Ser Leu Leu Leu Gly Pro Ser Phe Gln Ser Gln His
          35                  40                  45            
 Ser Phe Gln Pro Leu Glu Pro Lys Pro Asp Leu Thr Ser Ser Thr Ala
      50                  55                  60                
 Gly Ala Phe Ser Ala Leu Gly Ala Phe His Pro Asp His Arg Ala Glu
  65                  70                  75                  80
 Arg Pro Phe Pro Glu Glu Asp Pro Gly Pro Asp Gly Glu Gly Leu Leu
                  85                  90                  95    
 Lys Gln Gly Leu Pro Pro Ala Gln Leu Glu Gly Leu Lys Asn Phe Leu
             100                 105                 110        
 His Gln Leu Leu Glu Thr Val Pro Gln Asn Asn Glu Asn Pro Ser Val
         115                 120                 125            
 Asp Leu Leu Pro Pro Lys Ser Gly Pro Leu Thr Val Pro Ser Trp Glu
     130                 135                 140                
 Glu Ala Pro Gln Val Pro Arg Ile Pro Pro Pro Val His Lys Thr Lys
 145                 150                 155                 160
 Val Pro Leu Ala Met Ala Ser Ser Leu Phe Arg Val Pro Glu Pro Pro
                 165                 170                 175    
 Ser Ser His Ser Gln Gly Ser Gly Pro Ser Ser Gly Ser Pro Glu Arg
             180                 185                 190        
 Gly Gly Asp Gly Leu Thr Phe Pro Arg Gln Leu Met Glu Val Ser Gln
         195                 200                 205            
 Leu Leu Arg Leu Tyr Gln Ala Arg Gly Trp Gly Ala Leu Pro Ala Glu
     210                 215                 220                
 Asp Leu Leu Leu Tyr Leu Lys Arg Leu Glu His Ser Gly Arg Thr Asp
 225                 230                 235                 240
 Gly Arg Gly Asp Asn Val Pro Arg Arg Asn Thr Asp Ser Arg Leu Gly
                 245                 250                 255    
 Glu Ile Pro Arg Lys Glu Ile Pro Ser Gln Ala Val Pro Arg Arg Leu
             260                 265                 270        
 Ala Thr Ala Pro Lys Thr Glu Lys Pro Pro Ala Arg Lys Lys Ser Gly
         275                 280                 285            
 His Pro Ala Pro Ser Ser Met Arg Ser Arg Gly Gly Val Trp Arg
     290                 295                 300            



      <210> 825
      <211> 294
      <212> PRT
      <213> Homo sapiens


      <400> 825
 Met Leu Val Leu His Asn Ser Gln Lys Leu Gln Ile Leu Tyr Lys Ser
   1               5                  10                  15    
 Leu Glu Lys Ser Ile Pro Glu Ser Ile Lys Val Tyr Gly Ala Ile Phe
              20                  25                  30        
 Asn Ile Lys Asp Lys Asn Pro Phe Asn Met Glu Val Leu Val Asp Ala
          35                  40                  45            
 Trp Pro Asp Tyr Gln Ile Val Ile Thr Arg Pro Gln Lys Gln Glu Met
      50                  55                  60                
 Lys Asp Asp Gln Asp His Tyr Thr Asn Thr Tyr His Ile Phe Thr Lys
  65                  70                  75                  80
 Ala Pro Asp Lys Leu Glu Glu Val Leu Ser Tyr Ser Asn Val Ile Ser
                  85                  90                  95    
 Trp Glu Gln Thr Leu Gln Ile Gln Gly Cys Gln Glu Gly Leu Asp Glu
             100                 105                 110        
 Ala Ile Arg Lys Val Ala Thr Ser Lys Ser Val Gln Val Asp Tyr Met
         115                 120                 125            
 Lys Thr Ile Leu Phe Ile Pro Glu Leu Pro Lys Lys His Lys Thr Ser
     130                 135                 140                
 Ser Asn Asp Lys Met Glu Leu Phe Glu Val Asp Asp Asp Asn Lys Glu
 145                 150                 155                 160
 Gly Asn Phe Ser Asn Met Phe Leu Asp Ala Ser His Ala Gly Leu Val
                 165                 170                 175    
 Asn Glu His Trp Ala Phe Gly Lys Asn Glu Arg Ser Leu Lys Tyr Ile
             180                 185                 190        
 Glu Arg Cys Leu Gln Asp Phe Leu Gly Phe Gly Val Leu Gly Pro Glu
         195                 200                 205            
 Gly Gln Leu Val Ser Trp Ile Val Met Glu Gln Ser Cys Glu Leu Arg
     210                 215                 220                
 Met Gly Tyr Thr Val Pro Lys Tyr Arg His Gln Gly Asn Met Leu Gln
 225                 230                 235                 240
 Ile Gly Tyr His Leu Glu Lys Tyr Leu Ser Gln Lys Glu Ile Pro Phe
                 245                 250                 255    
 Tyr Phe His Val Ala Asp Asn Asn Glu Lys Ser Leu Gln Ala Leu Asn
             260                 265                 270        
 Asn Leu Gly Phe Lys Ile Cys Pro Cys Gly Trp His Gln Trp Lys Cys
         275                 280                 285            
 Thr Pro Lys Lys Tyr Cys
     290                



      <210> 826
      <211> 169
      <212> PRT
      <213> Homo sapiens


      <400> 826
 Met Ala Pro Ser Glu Asp Pro Arg Asp Trp Arg Ala Asn Leu Lys Gly
   1               5                  10                  15    
 Thr Ile Arg Glu Thr Gly Leu Glu Thr Ser Ser Gly Gly Lys Leu Ala
              20                  25                  30        
 Gly His Gln Lys Thr Val Pro Thr Ala His Leu Thr Phe Val Ile Asp
          35                  40                  45            
 Cys Thr His Gly Lys Gln Leu Ser Leu Ala Ala Thr Ala Ser Pro Pro
      50                  55                  60                
 Gln Ala Pro Ser Pro Asn Arg Gly Leu Val Thr Pro Pro Met Lys Thr
  65                  70                  75                  80
 Tyr Ile Val Phe Cys Gly Glu Asn Trp Pro His Leu Thr Arg Val Thr
                  85                  90                  95    
 Pro Met Gly Gly Gly Cys Leu Ala Gln Ala Arg Ala Thr Leu Pro Leu
             100                 105                 110        
 Cys Arg Gly Ser Val Ala Ser Ala Ser Phe Pro Val Ser Pro Leu Cys
         115                 120                 125            
 Pro Gln Glu Val Pro Glu Ala Lys Gly Lys Pro Val Lys Ala Ala Pro
     130                 135                 140                
 Val Arg Ser Ser Thr Trp Gly Thr Val Lys Asp Ser Leu Lys Ala Leu
 145                 150                 155                 160
 Ser Ser Cys Val Cys Gly Gln Ala Asp
                 165                



      <210> 827
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 827
 Met Leu Cys Ala Arg Pro Leu Leu Ser Pro Asn Pro Ile Pro Pro Val
   1               5                  10                  15    
 Cys Gln Leu Leu Lys Gly Leu Pro Thr Arg Arg Pro Leu Met Ala Arg
              20                  25                  30        
 Asp Pro Arg Gly Ala Trp Val Ala Met Pro Arg Pro His Pro Leu Pro
          35                  40                  45            
 Arg Arg Arg Arg Pro Pro Gly Ala Gly Lys Ala Gln Gly Arg Asp Pro
      50                  55                  60                
 Gln Pro Leu Pro Arg Pro Arg Gly Arg Gln Arg Trp Phe Val Cys Leu
  65                  70                  75                  80
 Ser Ser Ser Ser Arg Gly Cys Arg Glu Asn Leu Ala Cys Ser Arg His
                  85                  90                  95    
 Ser Pro Ala Gly Leu Glu Gly Ser Ala Pro Thr Cys Val Leu Ser Phe
             100                 105                 110        
 Ser Ser Val Arg Arg Tyr Leu Ser Pro Glu Arg Leu Ala Ser Val Arg
         115                 120                 125            
 Arg Glu Asp Pro Arg Ser Arg Thr Thr Ser Ser Ser Ser Asn Cys Ser
     130                 135                 140                
 Ala Lys Lys Glu Gly
 145                



      <210> 828
      <211> 294
      <212> PRT
      <213> Homo sapiens


      <400> 828
 Met Ala Gly Ser Glu Glu Leu Gly Leu Arg Glu Asp Thr Leu Arg Val
   1               5                  10                  15    
 Leu Ala Ala Phe Leu Arg Arg Gly Glu Ala Ala Gly Ser Pro Val Pro
              20                  25                  30        
 Thr Pro Pro Arg Ser Pro Ala Gln Glu Glu Pro Thr Asp Phe Leu Ser
          35                  40                  45            
 Arg Leu Arg Arg Cys Leu Pro Cys Ser Leu Gly Arg Gly Ala Ala Pro
      50                  55                  60                
 Ser Glu Ser Pro Arg Pro Cys Ser Leu Pro Ile Arg Pro Cys Tyr Gly
  65                  70                  75                  80
 Leu Glu Pro Gly Pro Ala Thr Pro Asp Phe Tyr Ala Leu Val Ala Gln
                  85                  90                  95    
 Arg Leu Glu Gln Leu Val Gln Glu Gln Leu Lys Ser Pro Pro Ser Pro
             100                 105                 110        
 Glu Leu Gln Gly Pro Pro Ser Thr Glu Lys Glu Ala Ile Leu Arg Arg
         115                 120                 125            
 Leu Val Ala Leu Leu Glu Glu Glu Ala Glu Val Ile Asn Gln Lys Leu
     130                 135                 140                
 Ala Ser Asp Pro Ala Leu Arg Ser Lys Leu Val Arg Leu Ser Ser Asp
 145                 150                 155                 160
 Ser Phe Ala Arg Leu Val Glu Leu Phe Cys Ser Arg Asp Asp Ser Ser
                 165                 170                 175    
 Arg Pro Ser Arg Ala Cys Pro Gly Pro Pro Pro Pro Ser Pro Glu Pro
             180                 185                 190        
 Leu Ala Arg Leu Ala Leu Ala Met Glu Leu Ser Arg Arg Val Ala Gly
         195                 200                 205            
 Leu Gly Gly Thr Leu Ala Gly Leu Ser Val Glu His Val His Ser Phe
     210                 215                 220                
 Thr Pro Leu Asp Pro Gly Pro Arg Gly Leu Gly Gly His Pro Gly Cys
 225                 230                 235                 240
 Phe Thr Arg Gly Leu Glu Leu Gly Thr Gly Ala Glu Arg Ser Ser His
                 245                 250                 255    
 Lys Ala Gly Thr Pro Ile Asp Leu His Val Leu Ala Ser Ser Gly Gly
             260                 265                 270        
 Tyr Gln Val Val Leu Tyr Thr Gln Gly Gly Gly Gly Gly Arg Leu Thr
         275                 280                 285            
 Val Cys Gln Ser Ile Gly
     290                



      <210> 829
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 829
 Met Asn Pro Arg Leu Gln Gly Gln Thr Ser Lys Pro Ala Asp Gln Met
   1               5                  10                  15    
 Met Asp Gly Gly Thr Thr Trp Gln Arg Lys Arg Glu Glu Glu Glu His
              20                  25                  30        
 Leu Asn Ala Lys Arg Ser Leu Ala Gly Gly Ser Gln Lys Gly Val Gln
          35                  40                  45            
 Leu Leu Gly Gly Pro Thr Pro Glu Glu Asp His Leu Pro Ile Pro Ser
      50                  55                  60                
 Pro Ser Ser Arg Ser Pro Ser Ile Ser Leu Pro Pro Pro Pro Leu Asn
  65                  70                  75                  80
 Lys Ile Leu His Leu Ser Ser Ser Leu Arg Val Thr
                  85                  90        



      <210> 830
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 830
 Met Asn Asn Gln Lys Val Val Ala Val Leu Leu Gln Glu Cys Lys Gln
   1               5                  10                  15    
 Val Leu Asp Gln Leu Leu Leu Glu Ala Pro Asp Val Ser Glu Glu Asp
              20                  25                  30        
 Lys Ser Glu Asp Gln Arg Cys Arg Ala Leu Leu Pro Ser Glu Leu Arg
          35                  40                  45            
 Thr Leu Ile Gln Glu Ala Lys Glu Met Lys Trp Pro Phe Val Pro Glu
      50                  55                  60                
 Lys Trp Gln Tyr Lys Gln Ala Val Gly Pro Glu Asp Lys Thr Asn Leu
  65                  70                  75                  80
 Lys Asp Val Ile Gly Ala Gly Leu Gln Gln Leu Leu Val Gly Arg Ala
                  85                  90                  95    
 Thr Pro Pro Val Pro Leu Ile Ser Pro Ser Leu Gly Val Leu Met Leu
             100                 105                 110        
 Glu Gly Asp Trp Leu Ile Ser Val Glu Gly Gly Ala Cys Cys Gln Ser
         115                 120                 125            
 Ala Leu Asp Leu Leu Trp Cys Pro Leu Thr Glu Ile Gln Asp His Phe
     130                 135                 140                
 Tyr Arg Leu Ala Leu Lys Ala Gln Ser Glu Asp Met Lys Gln Ala Gln
 145                 150                 155                 160
 Lys Glu Asp Ile Leu Phe Pro Met Ser Phe Ser Thr Leu Gln Pro
                 165                 170                 175



      <210> 831
      <211> 529
      <212> PRT
      <213> Homo sapiens


      <400> 831
 Met Asp Lys Lys Ser Thr Ala Glu Lys Leu Gly Lys Glu Leu Gly Leu
   1               5                  10                  15    
 Gln Ala Lys Glu Leu Ser Ala Val His Ser Ser His His Glu Ile Gly
              20                  25                  30        
 Val Asn Asp Ser Asn Leu Phe Ser Leu Glu Met Arg Glu Pro Leu Glu
          35                  40                  45            
 Ser Ser Asn Thr Lys Ser Phe His Ser Ala Val Glu Ile Lys Asn Arg
      50                  55                  60                
 Ser Gln His Glu Leu Pro Cys Phe Gln His His Gly Ile Asp Thr Pro
  65                  70                  75                  80
 Thr Ser Leu Gln Lys Arg Ser Ala Cys Cys Pro Pro Ser Leu Leu Arg
                  85                  90                  95    
 Leu Glu Glu Thr Ala Ser Ser Ser Gln Asp Gly Asp Pro Gln Ile Trp
             100                 105                 110        
 Asp Asp Leu Pro Phe Ser Glu Ser Leu Asn Lys Phe Leu Ala Val Leu
         115                 120                 125            
 Glu Ser Glu Ile Ala Val Thr Gln Ala Asp Val Ser Ser Arg Lys His
     130                 135                 140                
 His Val Asp Asn Asp Ile Asp Lys Phe His Ala Asp His Ser Ser Leu
 145                 150                 155                 160
 Ser Val Thr Pro Gln Arg Thr Thr Gly Ala Leu His Thr Pro Pro Ile
                 165                 170                 175    
 Ala Leu Arg Ser Ser Gln Val Ile Val Lys Ala Asn Cys Ser Lys Asp
             180                 185                 190        
 Asp Phe Leu Phe Asn Cys Lys Gly Asn Leu Ser Pro Ser Val Glu Lys
         195                 200                 205            
 Glu Ser Gln Pro Asp Asn Lys Val Glu Ala Val Ser Val Asn His Asn
     210                 215                 220                
 Gly Arg Asp Met Ser Glu Tyr Phe Leu Pro Asn Pro Tyr Leu Ser Ala
 225                 230                 235                 240
 Leu Ser Ser Ser Ser Lys Asp Leu Glu Thr Ile Val Thr Leu Lys Lys
                 245                 250                 255    
 Thr Ile Arg Ile Ser Pro His Arg Glu Ser Asp His Ser Ser Leu Asn
             260                 265                 270        
 Asn Lys Tyr Leu Asn Gly Cys Gly Glu Ile Ser Val Ser Glu Met Asn
         275                 280                 285            
 Glu Lys Leu Thr Thr Leu Cys Tyr Arg Lys Tyr Asn Asp Val Ser Asp
     290                 295                 300                
 Leu Cys Lys Leu Glu Asn Lys Gln Tyr Cys Arg Trp Ser Lys Asn Gln
 305                 310                 315                 320
 Asp Asp Ser Phe Thr Ile Cys Arg Lys Leu Thr Tyr Pro Leu Glu Thr
                 325                 330                 335    
 Leu Cys Asn Ser Pro Asn Arg Ser Thr Asn Thr Leu Lys Glu Met Pro
             340                 345                 350        
 Trp Gly His Ile Asn Asn Asn Val Thr Gln Ser Tyr Ser Ile Gly Tyr
         355                 360                 365            
 Glu Gly Ser Tyr Asp Ala Ser Ala Asp Leu Phe Asp Asp Ile Ala Lys
     370                 375                 380                
 Glu Met Asp Ile Ala Thr Glu Ile Thr Lys Lys Ser Gln Asp Ile Leu
 385                 390                 395                 400
 Leu Lys Trp Gly Thr Ser Leu Ala Glu Ser His Pro Ser Glu Ser Asp
                 405                 410                 415    
 Phe Ser Leu Arg Ser Leu Ser Glu Asp Phe Ile Gln Pro Ser Gln Lys
             420                 425                 430        
 Leu Ser Leu Gln Ser Leu Ser Asp Ser Arg His Ser Arg Thr Cys Ser
         435                 440                 445            
 Pro Thr Pro His Phe Gln Ser Asp Ser Glu Tyr Asn Phe Glu Asn Ser
     450                 455                 460                
 Gln Asp Phe Val Pro Cys Ser Gln Ser Thr Pro Ile Ser Gly Phe His
 465                 470                 475                 480
 Gln Thr Arg Ile His Gly Ile Asn Arg Ala Phe Lys Lys Pro Val Phe
                 485                 490                 495    
 Tyr Ser Asp Leu Asp Gly Asn Tyr Glu Lys Ile Arg Ile Phe Pro Glu
             500                 505                 510        
 Asn Asp Lys Gln Gln Ala Ser Pro Ser Cys Pro Lys Lys Tyr Lys Asn
         515                 520                 525            
 Thr
    



      <210> 832
      <211> 207
      <212> PRT
      <213> Homo sapiens


      <400> 832
 Met Ala Ser Glu Thr Glu Lys Thr His Ala Leu Leu Gln Thr Cys Ser
   1               5                  10                  15    
 Thr Glu Ser Leu Ile Ser Ser Leu Gly Leu Gly Ala Phe Cys Leu Val
              20                  25                  30        
 Ala Asp Arg Leu Leu Gln Phe Ser Thr Ile Gln Gln Asn Asp Trp Leu
          35                  40                  45            
 Arg Ala Leu Ser Asp Asn Ala Val His Cys Val Ile Gly Met Trp Ser
      50                  55                  60                
 Trp Ala Val Val Thr Gly Ile Lys Lys Lys Thr Asp Phe Gly Glu Ile
  65                  70                  75                  80
 Ile Leu Ala Gly Phe Leu Ala Ser Val Ile Asp Val Asp His Phe Phe
                  85                  90                  95    
 Leu Ala Gly Ser Met Ser Leu Lys Ala Ala Leu Thr Leu Pro Arg Arg
             100                 105                 110        
 Pro Phe Leu His Cys Ser Thr Val Ile Pro Val Val Val Leu Thr Leu
         115                 120                 125            
 Lys Phe Thr Met His Leu Phe Lys Leu Lys Asp Ser Trp Cys Phe Leu
     130                 135                 140                
 Pro Trp Met Leu Phe Ile Ser Trp Thr Ser His His Ile Arg Asp Gly
 145                 150                 155                 160
 Ile Arg His Gly Leu Trp Ile Cys Pro Phe Gly Lys Thr Ser Pro Leu
                 165                 170                 175    
 Pro Phe Trp Leu Tyr Val Ile Ile Thr Ser Ser Leu Pro His Ile Leu
             180                 185                 190        
 Cys Leu Arg Ser Val Phe Thr Gly Pro Thr Met Val Phe Ser Thr
         195                 200                 205        



      <210> 833
      <211> 95
      <212> PRT
      <213> Homo sapiens


      <400> 833
 Met Ala Pro Arg Ala Arg Pro Arg Met Gln Arg Asp Trp Trp Val Gly
   1               5                  10                  15    
 Gly Gly Asp Ala Thr Thr Glu Arg Lys Leu Gly Asn Glu Glu Arg Ser
              20                  25                  30        
 Pro Glu Ala Leu Leu Leu Gln Arg Lys Pro Leu Ser Lys Glu Gly Lys
          35                  40                  45            
 Ala Trp Pro Ala Ala Pro Thr Trp Pro Gly Gly Gly Pro Trp Gly Thr
      50                  55                  60                
 Thr Thr Leu Gln Ala Gly Ser Gly Lys Val Arg Glu Ala Pro Asp Gly
  65                  70                  75                  80
 Thr Thr His Arg Phe Gly Trp Arg Gly Gln Gly Thr Leu Gly Trp
                  85                  90                  95



      <210> 834
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 834
 Met Pro Asp Val Trp Gly Cys Leu Ala Thr Val Ser Thr His Lys Lys
   1               5                  10                  15    
 Ile Gln Gly Leu Pro Phe Gly Asn Cys Leu Pro Val Ser Asp Gly Pro
              20                  25                  30        
 Phe Asn Asn Ser Thr Gly Ile Pro Phe Phe Tyr Met Thr Ala Lys Asp
          35                  40                  45            
 Pro Val Val Ala Asp Leu Met Lys Asn Pro Met Ala Ser Leu Met Leu
      50                  55                  60                
 Pro Glu Ser Glu Gly Glu Phe Cys Arg Lys Asn Ile Val Asp Pro Glu
  65                  70                  75                  80
 Asp Pro Arg Cys Val Gln Leu Thr Leu Thr Gly Gln Met Ile Ala Val
                  85                  90                  95    
 Ser Pro Glu Glu Val Glu Phe Ala Lys Gln Ala Met Phe Ser Arg His
             100                 105                 110        
 Pro Gly Met Arg Lys Trp Pro Arg Gln Tyr Glu Trp Phe Phe Met Lys
         115                 120                 125            
 Met Arg Ile Glu His Ile Trp Leu Gln Lys Trp Tyr Gly Gly Ala Ser
     130                 135                 140                
 Ser Ile Ser Arg Glu Glu Tyr Phe Lys Ala Val Pro Arg Lys Ala
 145                 150                 155                



      <210> 835
      <211> 282
      <212> PRT
      <213> Homo sapiens


      <400> 835
 Met Ala Ala Ala Ala Pro Asp Ser Arg Val Ser Glu Glu Glu Asn Leu
   1               5                  10                  15    
 Lys Lys Thr Pro Lys Lys Lys Met Lys Met Val Thr Gly Ala Val Ala
              20                  25                  30        
 Ser Val Leu Glu Asp Glu Ala Thr Asp Thr Ser Asp Ser Glu Gly Ser
          35                  40                  45            
 Cys Gly Ser Glu Lys Asp His Phe Tyr Ser Asp Asp Asp Ala Ile Glu
      50                  55                  60                
 Ala Asp Ser Glu Gly Asp Ala Glu Pro Cys Asp Lys Glu Asn Glu Asn
  65                  70                  75                  80
 Asp Gly Glu Ser Ser Val Gly Thr Asn Met Gly Trp Ala Asp Ala Met
                  85                  90                  95    
 Ala Lys Val Leu Asn Lys Lys Thr Pro Glu Ser Lys Pro Thr Ile Leu
             100                 105                 110        
 Val Lys Asn Lys Lys Leu Glu Lys Glu Lys Glu Lys Leu Lys Gln Glu
         115                 120                 125            
 Arg Leu Glu Lys Ile Lys Gln Arg Asp Lys Arg Leu Glu Trp Glu Met
     130                 135                 140                
 Met Cys Arg Val Lys Pro Asp Val Val Gln Asp Lys Glu Thr Glu Arg
 145                 150                 155                 160
 Asn Leu Gln Arg Ile Ala Thr Arg Gly Val Val Gln Leu Phe Asn Ala
                 165                 170                 175    
 Val Gln Lys His Gln Lys Asn Val Asp Glu Lys Val Lys Glu Ala Gly
             180                 185                 190        
 Ser Ser Met Arg Lys Arg Ala Lys Leu Ile Ser Thr Val Ser Lys Lys
         195                 200                 205            
 Asp Phe Ile Ser Val Leu Arg Gly Met Asp Gly Ser Thr Asn Glu Thr
     210                 215                 220                
 Ala Ser Ser Arg Lys Lys Pro Lys Ala Lys Gln Thr Glu Val Lys Ser
 225                 230                 235                 240
 Glu Glu Gly Pro Gly Trp Thr Ile Leu Arg Asp Asp Phe Met Met Gly
                 245                 250                 255    
 Ala Ser Met Lys Asp Trp Asp Lys Glu Ser Asp Gly Pro Asp Asp Ser
             260                 265                 270        
 Arg Pro Glu Ser Ala Ser Asp Ser Asp Thr
         275                 280        



      <210> 836
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 836
 Met Gly Glu Gln Cys Pro Arg Asn Ala Val Ser Arg Leu Arg Leu Cys
   1               5                  10                  15    
 Gln Gly Leu Leu Leu Arg Ala Leu Pro Leu Ala Ala Ser Asp Arg Gly
              20                  25                  30        
 Gly Phe Ile Met Lys Gln Thr Arg Leu Asn Pro Pro Val Val Phe Ile
          35                  40                  45            
 Leu Leu Gln Pro Leu Ser Arg Pro Arg Asp Gly Leu Ser Asn Ser Val
      50                  55                  60                
 Leu Ile Ile Leu His Ser Val Pro
  65                  70        



      <210> 837
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 837
 Met Cys Thr Ser Trp Ala Ala Ser Pro Asp Ser Gly Arg Pro Gly Asn
   1               5                  10                  15    
 Leu Gly Leu Glu Gln Ser Leu Ser Ala Gly Ser Thr Asn Arg Leu Pro
              20                  25                  30        
 Arg Met Ser Leu His Trp Phe Leu Arg Leu Pro Leu Arg Ala Leu Pro
          35                  40                  45            
 Trp Ala Met Trp Lys Ser Ile Asn Arg Arg Arg Lys Ser Ile Lys Pro
      50                  55                  60                
 Trp Lys Ala Asn Pro Thr Gly Thr Arg Ser Pro Arg Pro Leu His Ser
  65                  70                  75                  80
 Phe Thr Ala Pro Gln Ile Ile Cys Pro Ile Gly Phe Arg Pro Leu Cys
                  85                  90                  95    
 Ile Leu Phe Gly Phe
             100    



      <210> 838
      <211> 160
      <212> PRT
      <213> Homo sapiens


      <400> 838
 Met Cys Trp Gln Leu Arg Gly Lys Trp Gln Cys Gly Val Gly Asp Phe
   1               5                  10                  15    
 Ala Leu Gly Leu Val Pro Phe Arg Pro Pro Gly Leu Pro Leu Pro His
              20                  25                  30        
 Ser Ser Gln Phe Leu Trp Ser Leu Ser Ile Leu Pro Leu Ser Val His
          35                  40                  45            
 Pro Cys Thr Arg His Thr Pro Phe Ser Tyr Ala Phe Gly Val Leu Asp
      50                  55                  60                
 Gly Asn Leu Gly Gly Glu Arg Lys Asp Arg Ser Gly Leu Pro Gln Pro
  65                  70                  75                  80
 Leu Leu Leu Leu Ser Pro Arg Val Arg Ile Ala Gly Ala Pro Pro Pro
                  85                  90                  95    
 Ser Trp Phe Leu Arg Thr Arg Pro Phe Ser Phe Cys Leu Tyr Leu Leu
             100                 105                 110        
 Arg Ile Leu Ser Leu Leu Met Trp Leu Thr Pro Leu Pro Pro Leu Pro
         115                 120                 125            
 Ala Gly Gly Trp Pro Gly Gly Gln Val Pro Ala Gly Ala Val Asn Arg
     130                 135                 140                
 Ala Leu Arg Phe Cys Ala Gly Leu Cys Val Cys Cys Ile Ser Val Phe
 145                 150                 155                 160





      <210> 839
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 839
 Met Gly Leu Pro Ser Pro Ile Leu His Ala Thr Ser Thr Leu Arg Pro
   1               5                  10                  15    
 Asp Gln Phe Ser Pro His Thr Asn Pro Ser Leu Ser Leu Pro Cys Leu
              20                  25                  30        
 Lys Ser Phe Pro Val Ser Leu Trp Pro Trp Gly Arg Ala Ser Leu Leu
          35                  40                  45            
 Cys His Leu Ser Arg Leu Phe Val Cys His Arg Pro Leu Thr Pro Thr
      50                  55                  60                
 Ser Gln Ala Pro Asn Met Phe Ser Cys Val Ser Ser Ser Leu Thr Leu
  65                  70                  75                  80
 Ala Ala Ser Ser Ala Trp Pro Ala Ser His Leu Pro Ile Ser His Ser
                  85                  90                  95    
 Pro Phe Leu Pro Pro His Leu Leu Arg Ser Gln Leu Ser Val Thr Ser
             100                 105                 110        
 Ser Arg Glu Pro Arg Leu Ser Leu Pro Leu Gln Leu Gly Gln
         115                 120                 125    



      <210> 840
      <211> 439
      <212> PRT
      <213> Homo sapiens


      <400> 840
 Met Lys Leu Val Thr Lys His Phe Pro Gly Glu Phe Gly Ser Glu Ile
   1               5                  10                  15    
 Leu Val Gln Lys Val Val His Thr Ile Leu His Gln Thr Ala Lys Lys
              20                  25                  30        
 Asn Pro Asp Asp Tyr Thr Pro Val Asn Ile Asp Gly Ala His Ala Gln
          35                  40                  45            
 Arg Val Gly Asp Val Gln Gly Gln Glu Ser Glu Ser Gln Leu Pro Thr
      50                  55                  60                
 Lys Ile Ile Leu Thr Gly Gln Lys Thr Lys Thr Leu His Lys Glu Glu
  65                  70                  75                  80
 Leu Asn Met Ser Lys Thr Glu Arg Thr Ile Gln Gln Asn Ile Thr Glu
                  85                  90                  95    
 Gln Ala Ser Val Met Gln Lys Arg Lys Thr Glu Lys Leu Lys Gln Glu
             100                 105                 110        
 Gln Lys Gly Gln Pro Arg Thr Val Ser Pro Ser Thr Ile Arg Asp Gly
         115                 120                 125            
 Pro Ser Ser Ala Pro Ala Thr Pro Thr Lys Ala Pro Tyr Ser Pro Thr
     130                 135                 140                
 Thr Ser Lys Glu Lys Lys Ile Arg Ile Thr Thr Asn Asp Gly Arg Gln
 145                 150                 155                 160
 Ser Met Val Thr Leu Lys Ser Ser Thr Thr Phe Phe Glu Leu Gln Glu
                 165                 170                 175    
 Ser Ile Ala Arg Glu Phe Asn Ile Phe Pro Tyr Leu Gln Cys Ile Arg
             180                 185                 190        
 Tyr Gly Phe Pro Pro Lys Glu Leu Met Pro Pro Gln Ala Gly Met Glu
         195                 200                 205            
 Lys Glu Pro Val Pro Leu Gln His Gly Asp Arg Ile Thr Ile Glu Ile
     210                 215                 220                
 Leu Lys Ser Lys Ala Glu Gly Gly Gln Ser Ala Ala Ala His Ser Ala
 225                 230                 235                 240
 His Thr Val Lys Gln Glu Asp Ile Ala Val Thr Gly Lys Leu Ser Ser
                 245                 250                 255    
 Lys Glu Leu Gln Glu Gln Ala Glu Lys Glu Met Tyr Ser Leu Cys Leu
             260                 265                 270        
 Leu Ala Thr Leu Met Gly Glu Asp Val Trp Ser Tyr Ala Lys Gly Leu
         275                 280                 285            
 Pro His Met Phe Gln Gln Gly Gly Val Phe Tyr Ser Ile Met Lys Lys
     290                 295                 300                
 Thr Met Gly Met Ala Asp Gly Lys His Cys Thr Phe Pro His Leu Pro
 305                 310                 315                 320
 Gly Lys Thr Phe Val Tyr Asn Ala Ser Glu Asp Arg Leu Glu Leu Cys
                 325                 330                 335    
 Val Asp Ala Ala Gly His Phe Pro Ile Gly Pro Asp Val Glu Asp Leu
             340                 345                 350        
 Val Lys Glu Ala Val Ser Gln Val Arg Ser Glu Ala Thr Thr Arg Ser
         355                 360                 365            
 Arg Glu Ser Ser Pro Ser His Gly Leu Leu Lys Leu Gly Ser Gly Gly
     370                 375                 380                
 Val Val Lys Lys Lys Ser Glu Gln Leu His Asn Val Thr Ala Phe Gln
 385                 390                 395                 400
 Gly Lys Gly His Ser Leu Gly Thr Ala Ser Gly Asn Pro His Leu Asp
                 405                 410                 415    
 Pro Arg Ala Arg Glu Thr Ser Val Val Arg Lys His Asn Thr Gly Thr
             420                 425                 430        
 Asp Phe Ser Asn Ser Ser Thr
         435                



      <210> 841
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 841
 Met His Ala Ser Asn Ser Leu Asn Phe Gly Phe Ser Tyr Leu Lys His
   1               5                  10                  15    
 Phe Ser Gly Ile Phe Pro Phe Leu Met Leu Trp Gly Gly Asn Arg Met
              20                  25                  30        
 Ala Asn His Cys Glu Pro Asp Thr Ser Ala Gln Ser Thr Leu Cys Val
          35                  40                  45            
 Thr Ser Gln Met Gly Asp Phe Thr Asn Gly Val Thr Glu Cys Tyr Tyr
      50                  55                  60                
 Phe Gln Ile Leu Thr Trp Ser Ile Met Ile Lys Glu Met Glu Leu Pro
  65                  70                  75                  80
 Tyr Thr Leu Asn Pro
                  85



      <210> 842
      <211> 269
      <212> PRT
      <213> Homo sapiens


      <400> 842
 Met Asn Gln Glu Asp Leu Asp Pro Asp Ser Thr Thr Asp Val Gly Asp
   1               5                  10                  15    
 Val Thr Asn Thr Glu Glu Glu Leu Ile Arg Glu Cys Glu Glu Met Trp
              20                  25                  30        
 Lys Asp Met Glu Glu Cys Gln Asn Lys Leu Ser Leu Ile Gly Thr Glu
          35                  40                  45            
 Thr Leu Thr Asp Ser Asn Ala Gln Leu Ser Leu Leu Ile Met Gln Val
      50                  55                  60                
 Lys Cys Leu Thr Ala Glu Leu Ser Gln Trp Gln Lys Lys Thr Pro Glu
  65                  70                  75                  80
 Thr Ile Pro Leu Thr Glu Asp Val Leu Ile Thr Leu Gly Lys Glu Glu
                  85                  90                  95    
 Phe Gln Lys Leu Arg Gln Asp Leu Glu Met Val Leu Ser Thr Lys Glu
             100                 105                 110        
 Ser Lys Asn Glu Lys Leu Lys Glu Asp Leu Glu Arg Glu Gln Arg Trp
         115                 120                 125            
 Leu Asp Glu Gln Gln Gln Ile Met Glu Ser Leu Asn Val Leu His Ser
     130                 135                 140                
 Glu Leu Lys Asn Lys Val Glu Thr Phe Ser Glu Ser Arg Ile Phe Asn
 145                 150                 155                 160
 Glu Leu Lys Thr Lys Met Leu Asn Ile Lys Glu Tyr Lys Glu Lys Leu
                 165                 170                 175    
 Leu Ser Thr Leu Gly Glu Phe Leu Glu Asp His Phe Pro Leu Pro Asp
             180                 185                 190        
 Arg Ser Val Lys Lys Lys Lys Lys Asn Ile Gln Glu Ser Ser Val Asn
         195                 200                 205            
 Leu Ile Thr Leu His Val Met Leu Glu Ile Leu Ile Asn Arg Leu Phe
     210                 215                 220                
 Asp Val Pro His Asp Pro Tyr Val Lys Ile Ser Asp Ser Phe Gly His
 225                 230                 235                 240
 Leu Met Leu Ser Cys Cys Cys Val Met Glu Cys Ala Leu Arg His Pro
                 245                 250                 255    
 Glu Asp Pro Thr Arg Ile Arg Leu Glu Ala Phe His Gln
             260                 265                



      <210> 843
      <211> 311
      <212> PRT
      <213> Homo sapiens


      <400> 843
 Met Gln Asp Thr Lys Asp Glu His Arg Leu His Ser Gly Lys Leu Cys
   1               5                  10                  15    
 Leu Ile Ile Leu Thr Cys Ile Ala Glu Asp Gln Tyr Ala Asn Ala Phe
              20                  25                  30        
 Leu His Asp Asp Asn Met Asn Phe Arg Val Asn Leu His Arg Met Pro
          35                  40                  45            
 Met Arg His Arg Lys Lys Ala Ala Asp Lys Asn Leu Pro Cys Arg Pro
      50                  55                  60                
 Leu Val Cys Ala Val Leu Asp Leu Met Val Glu Phe Ile Val Thr His
  65                  70                  75                  80
 Met Met Lys Glu Phe Pro Met Asp Leu Tyr Ile Arg Cys Ile Gln Val
                  85                  90                  95    
 Val His Lys Leu Leu Cys Tyr Gln Lys Lys Cys Arg Val Arg Leu His
             100                 105                 110        
 Tyr Thr Trp Arg Glu Leu Trp Ser Ala Leu Ile Asn Leu Leu Lys Phe
         115                 120                 125            
 Leu Met Ser Asn Glu Thr Val Leu Leu Ala Lys His Asn Ile Phe Thr
     130                 135                 140                
 Leu Ala Leu Met Ile Val Asn Leu Phe Asn Met Phe Ile Thr Tyr Gly
 145                 150                 155                 160
 Asp Thr Phe Leu Pro Thr Pro Ser Ser Tyr Asp Glu Leu Tyr Tyr Glu
                 165                 170                 175    
 Ile Ile Arg Met His Gln Ser Phe Asp Asn Leu Tyr Ser Met Val Leu
             180                 185                 190        
 Arg Leu Ser Thr Asn Ala Gly Gln Trp Lys Glu Ala Ala Ser Lys Val
         195                 200                 205            
 Thr His Ala Leu Val Asn Ile Arg Ala Ile Ile Asn His Phe Asn Pro
     210                 215                 220                
 Lys Ile Glu Ser Tyr Ala Ala Val Asn His Ile Ser Gln Leu Ser Glu
 225                 230                 235                 240
 Glu Gln Val Leu Glu Val Val Arg Ala Asn Tyr Asp Thr Leu Thr Leu
                 245                 250                 255    
 Lys Leu Gln Asp Gly Leu Asp Gln Tyr Glu Arg Tyr Ser Glu Gln His
             260                 265                 270        
 Lys Glu Ala Ala Phe Phe Lys Glu Leu Val Arg Ser Ile Ser Thr Asn
         275                 280                 285            
 Val Arg Arg Asn Leu Ala Phe His Thr Leu Ser Gln Glu Val Leu Leu
     290                 295                 300                
 Lys Glu Phe Ser Thr Ile Ser
 305                 310    



      <210> 844
      <211> 191
      <212> PRT
      <213> Homo sapiens


      <400> 844
 Met Cys Phe Ser Arg Ala Asp Ala Ala Asp Asn Tyr Pro Phe Gly Thr
   1               5                  10                  15    
 Cys Gln Gln Arg Lys Leu Phe Pro His Phe His Pro Pro Asn Leu Ile
              20                  25                  30        
 Gly Asn Lys Phe Val Pro Leu Arg Gly Ser Pro His Arg Gly Pro Gly
          35                  40                  45            
 Cys Tyr Phe Ser Asp Gly Tyr Gly Leu Ala Tyr Asp Leu Ser Lys Ile
      50                  55                  60                
 Pro Thr Ser Ile Lys Gly Tyr Thr Leu Gly Ala Arg Thr Ala Val Arg
  65                  70                  75                  80
 Phe Lys Pro Ile Gln Lys Glu Met Thr Pro His Ala Gly Arg Tyr Gln
                  85                  90                  95    
 Lys Val Ser Pro Gln Gln Glu Lys His Lys Gln Asn Phe Ala Pro Phe
             100                 105                 110        
 Asn Val Leu Val Pro Arg Phe Lys Asn Tyr Pro Lys Asp Thr Tyr Tyr
         115                 120                 125            
 Pro Ser Pro Gly Ala Tyr Asn Pro Glu Lys Lys Pro Pro Pro Lys Ile
     130                 135                 140                
 Ala Trp Pro Met Lys Phe Gly Ser Pro Asp Trp Ala Gln Val Pro Cys
 145                 150                 155                 160
 Leu Gln Lys Arg Thr Leu Lys Ala Glu Leu Ser Thr Asp Lys Asp Phe
                 165                 170                 175    
 Arg Lys His Arg Asn Arg Val Ala Tyr Leu Ser Leu Tyr Tyr Asn
             180                 185                 190    



      <210> 845
      <211> 108
      <212> PRT
      <213> Homo sapiens


      <400> 845
 Met Gly Ser Ser Ser Glu Ala Ser Phe Arg Ser Ala Gln Ala Ser Cys
   1               5                  10                  15    
 Ser Gly Ala Arg Arg Gln Gly Leu Gly Arg Gly Asp Gln Asn Leu Ser
              20                  25                  30        
 Val Met Pro Pro Asn Gly Arg Ala Gln Thr His Thr Pro Gly Trp Val
          35                  40                  45            
 Ser Pro Cys Ser Glu Asn Arg Asp Gly Leu Leu Pro Ala Thr Ala Pro
      50                  55                  60                
 Gly Arg Leu Cys Ser His Arg Gly Ala Asp Ile Pro Ser Phe Gln Thr
  65                  70                  75                  80
 His Gln Asp Pro Val Thr Ala Ser Gly Ser Ser Glu Leu His Ala Asp
                  85                  90                  95    
 Cys Pro Gln Phe Arg Ala Leu Asp Arg Ala Gly Asn
             100                 105            



      <210> 846
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 846
 Met Thr Val Lys Ser Ile Lys Asp Thr Thr Met Phe Tyr Ser Lys Ile
   1               5                  10                  15    
 Leu Gly Met Glu Val Met Thr Phe Lys Glu Asp Arg Lys Ala Leu Cys
              20                  25                  30        
 Phe Gly Asp Gln Lys Phe Asn Leu His Glu Val Gly Lys Glu Phe Glu
          35                  40                  45            
 Pro Lys Ala Ala His Pro Val Pro Gly Ser Leu Asp Ile Cys Leu Ile
      50                  55                  60                
 Thr Glu Val Pro Leu Glu Glu Met Ile Gln His Leu Lys Ala Cys Asp
  65                  70                  75                  80
 Val Pro Ile Glu Glu Gly Pro Val Pro Arg Thr Gly Ala Lys Gly Pro
                  85                  90                  95    
 Ile Met Ser Ile Tyr Phe Arg Asp Pro Asp Arg Asn Leu Ile Glu Val
             100                 105                 110        
 Ser Asn Tyr Ile Ser Ser
         115            



      <210> 847
      <211> 368
      <212> PRT
      <213> Homo sapiens


      <400> 847
 Met Thr Arg Gly Phe Ala Pro Ile Leu Pro Val Glu Phe His Lys Met
   1               5                  10                  15    
 Gly Ser Phe Arg Arg Pro Arg Pro Arg Phe Met Ser Ser Pro Val Leu
              20                  25                  30        
 Ser Asp Leu Pro Arg Phe Gln Ala Thr Arg Gln Ala Leu Gln Leu Ser
          35                  40                  45            
 Ser Ser Ser Ala Trp Asn Ser Val Gln Thr Ala Val Ile Asn Val Phe
      50                  55                  60                
 Lys Gly Gly Gly Leu Gln Ser Asn Glu Leu Tyr Ala Leu Asn Glu Asn
  65                  70                  75                  80
 Ile Arg Arg Leu Leu Lys Ser Glu Leu Gly Ser Phe Ile Thr Asp Tyr
                  85                  90                  95    
 Phe Gln Asn Gln Leu Leu Ala Lys Gly Leu Phe Phe Val Glu Glu Lys
             100                 105                 110        
 Ile Lys Leu Cys Glu Gly Glu Asn Arg Ile Glu Val Leu Ala Glu Val
         115                 120                 125            
 Trp Asp His Phe Phe Thr Glu Thr Leu Pro Thr Leu Gln Ala Ile Phe
     130                 135                 140                
 Tyr Pro Val Gln Gly Gln Glu Leu Thr Ile Arg Gln Ile Ser Leu Leu
 145                 150                 155                 160
 Gly Phe Arg Asp Leu Val Leu Leu Lys Val Lys Leu Gly Asp Leu Leu
                 165                 170                 175    
 Leu Leu Ala Gln Ser Lys Leu Pro Ser Ser Ile Val Gln Met Leu Leu
             180                 185                 190        
 Ile Leu Gln Ser Val His Glu Pro Thr Gly Pro Ser Glu Ser Tyr Leu
         195                 200                 205            
 Gln Leu Glu Glu Leu Val Lys Gln Val Val Ser Pro Phe Leu Gly Ile
     210                 215                 220                
 Ser Gly Asp Arg Ser Phe Ser Gly Pro Thr Tyr Thr Leu Ala Arg Arg
 225                 230                 235                 240
 His Ser Arg Val Arg Pro Lys Val Thr Val Leu Asn Tyr Ala Ser Pro
                 245                 250                 255    
 Ile Thr Ala Val Ser Arg Pro Leu Asn Glu Met Val Leu Thr Pro Leu
             260                 265                 270        
 Thr Glu Gln Glu Gly Glu Ala Tyr Leu Glu Lys Cys Gly Ser Val Arg
         275                 280                 285            
 Arg His Thr Val Ala Asn Ala His Ser Asp Ile Gln Leu Leu Ala Met
     290                 295                 300                
 Ala Thr Met Met His Ser Gly Leu Gly Glu Glu Ala Ser Ser Glu Asn
 305                 310                 315                 320
 Lys Cys Leu Leu Leu Pro Pro Ser Phe Pro Pro Pro His Arg Gln Cys
                 325                 330                 335    
 Ser Ser Glu Pro Asn Ile Thr Asp Asn Pro Asp Gly Leu Glu Glu Gly
             340                 345                 350        
 Ala Arg Gly Ser Gln Glu Gly Ser Glu Leu Asn Cys Ala Ser Leu Ser
         355                 360                 365            





      <210> 848
      <211> 501
      <212> PRT
      <213> Homo sapiens


      <400> 848
 Met Val Gly Gln Ser Asn Val Pro His Tyr Gln His Leu Arg Val Phe
   1               5                  10                  15    
 Tyr Ala Arg Leu Ala Pro Gly Tyr Ile Asn Gln Glu Val Val Arg Leu
              20                  25                  30        
 Tyr Leu Ala Ala Leu Ser Asp Arg Thr Pro Gln Asn Leu His Ala Phe
          35                  40                  45            
 Leu Ile Ser Val Pro Gly Ser Phe Ala Glu Ser Gly Ala Thr Lys Asn
      50                  55                  60                
 Leu Leu Asp Ser Met Ala Arg Asn Val Val Leu Asp Ala Leu Gln Leu
  65                  70                  75                  80
 Pro Lys Ser Trp Leu Asn Gly Ser Ser Leu Leu Gln His Met Lys Phe
                  85                  90                  95    
 Asn Asn Pro Phe Tyr Phe Ser Phe Ser Arg Cys Thr Leu Ser Gly Gly
             100                 105                 110        
 His Leu Ile Gln Gln Val Ile Ile Gly Gly Lys Asp Leu Arg Ser Leu
         115                 120                 125            
 Ala Ser Leu Asn Leu Ser Gly Cys Val His Cys Leu Ser Pro Asp Ser
     130                 135                 140                
 Leu Leu Arg Lys Ala Glu Asp Asp Ile Val Ser Ser Ile Leu Glu Thr
 145                 150                 155                 160
 Leu Val Ala Ser Cys Cys Asn Leu Arg His Leu Asn Leu Ser Ala Ala
                 165                 170                 175    
 His His His Ser Ser Glu Gly Leu Gly Arg His Leu Cys Gln Leu Leu
             180                 185                 190        
 Ala Arg Leu Arg His Leu Arg Ser Leu Ser Leu Pro Val Cys Ser Val
         195                 200                 205            
 Ala Asp Ser Ala Pro Arg Ala Asp Arg Ala Pro Ala Gln Pro Ala Met
     210                 215                 220                
 His Ala Val Pro Arg Gly Phe Gly Lys Lys Val Arg Val Gly Val Gln
 225                 230                 235                 240
 Ser Cys Pro Ser Pro Phe Ser Gly Gln Ala Cys Pro Gln Pro Ser Ser
                 245                 250                 255    
 Val Phe Trp Ser Leu Leu Lys Asn Leu Pro Phe Leu Glu His Leu Glu
             260                 265                 270        
 Leu Ile Gly Ser Asn Phe Ser Ser Ala Met Pro Arg Asn Glu Pro Ala
         275                 280                 285            
 Ile Arg Asn Ser Leu Pro Pro Cys Ser Arg Ala Gln Ser Val Gly Asp
     290                 295                 300                
 Ser Glu Val Ala Ala Ile Gly Gln Leu Ala Phe Leu Arg His Leu Thr
 305                 310                 315                 320
 Leu Ala Gln Leu Pro Ser Val Leu Thr Gly Ser Gly Leu Val Asn Ile
                 325                 330                 335    
 Gly Leu Gln Cys Gln Gln Leu Arg Ser Leu Ser Leu Ala Asn Leu Gly
             340                 345                 350        
 Met Met Gly Lys Val Val Tyr Met Pro Ala Leu Ser Asp Met Leu Lys
         355                 360                 365            
 His Cys Lys Arg Leu Arg Asp Leu Arg Leu Glu Gln Pro Tyr Phe Ser
     370                 375                 380                
 Ala Asn Ala Gln Phe Phe Gln Ala Leu Ser Gln Cys Pro Ser Leu Gln
 385                 390                 395                 400
 Arg Leu Cys Leu Val Ser Arg Ser Gly Thr Leu Gln Pro Asp Ala Val
                 405                 410                 415    
 Leu Ala Phe Met Ala Arg Cys Leu Gln Val Val Met Cys His Leu Phe
             420                 425                 430        
 Thr Gly Glu Ser Leu Ala Thr Cys Lys Ser Leu Gln Gln Ser Leu Leu
         435                 440                 445            
 Arg Ser Phe Gln Ala Glu Arg Pro Ala Leu Asn Val Val Ile Phe Pro
     450                 455                 460                
 Leu Leu His Glu Gly Leu Thr Asp Val Ile Arg Asp Val Pro Leu Val
 465                 470                 475                 480
 His Leu Asp Glu Ile Thr Leu Phe Lys Ser Arg Val Ala Glu Glu Pro
                 485                 490                 495    
 Pro Asn Leu Trp Trp
             500    



      <210> 849
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 849
 Met Trp Val Lys Gly Pro Thr Met Gly Thr Tyr Thr Gln Glu Asp Glu
   1               5                  10                  15    
 Ser Ser Leu Ala Ser Glu Ser Asp Cys Leu Pro Gln Thr Pro Pro Gln
              20                  25                  30        
 Asn Arg Leu Leu Ser His Leu Pro Leu His Ser Asp Lys Thr Gln Ala
          35                  40                  45            
 His Ile Pro Gly Pro Val Tyr Ile Lys
      50                  55        



      <210> 850
      <211> 417
      <212> PRT
      <213> Homo sapiens


      <400> 850
 Met Thr Gly Gly Arg Phe Asp Phe Asp Asp Gly Gly Thr Tyr Cys Gly
   1               5                  10                  15    
 Gly Trp Glu Glu Gly Lys Ala His Gly His Gly Ile Cys Thr Gly Pro
              20                  25                  30        
 Lys Gly Gln Gly Glu Tyr Ser Gly Ser Trp Ser His Gly Phe Glu Val
          35                  40                  45            
 Val Gly Gly Tyr Thr Trp Pro Ser Gly Asn Thr Tyr Gln Gly Tyr Trp
      50                  55                  60                
 Ala Gln Gly Lys Arg His Gly Leu Gly Val Glu Thr Lys Gly Lys Trp
  65                  70                  75                  80
 Met Tyr Arg Gly Glu Trp Ser His Gly Phe Lys Gly Arg Tyr Gly Val
                  85                  90                  95    
 Arg Gln Ser Leu Cys Thr Pro Ala Arg Tyr Glu Gly Thr Trp Ser Asn
             100                 105                 110        
 Gly Leu Gln Asp Gly Tyr Gly Val Glu Thr Tyr Gly Asp Gly Gly Leu
         115                 120                 125            
 Arg Gln Cys Ala Leu Asp Gly Ala Gly Asp Gly Ala Ala Leu Pro Pro
     130                 135                 140                
 Thr His Gly Ala Phe Leu Arg Ser Leu Gln Gly Thr Tyr Gln Gly Gln
 145                 150                 155                 160
 Trp Ala Gly Gly Met Arg His Gly Tyr Gly Val Arg Gln Ser Val Pro
                 165                 170                 175    
 Tyr Gly Met Ala Thr Val Ile Arg Ser Pro Leu Arg Thr Ser Leu Ala
             180                 185                 190        
 Ser Leu Arg Ser Glu Gln Ser Asn Gly Ser Val Leu His Asp Ala Ala
         195                 200                 205            
 Ala Ala Ala Asp Ser Pro Ala Gly Thr Arg Gly Gly Phe Val Leu Asn
     210                 215                 220                
 Phe His Ala Asp Ala Glu Leu Ala Gly Lys Lys Lys Gly Gly Leu Phe
 225                 230                 235                 240
 Arg Arg Gly Ser Leu Leu Gly Ser Met Lys Leu Arg Lys Ser Glu Ser
                 245                 250                 255    
 Lys Ser Ser Ile Ser Ser Lys Arg Ser Ser Val Arg Ser Asp Ala Ala
             260                 265                 270        
 Met Ser Arg Ile Ser Ser Ser Asp Ala Asn Ser Thr Ile Ser Phe Gly
         275                 280                 285            
 Asp Val Asp Cys Asp Phe Cys Pro Val Glu Asp His Val Asp Ala Thr
     290                 295                 300                
 Thr Thr Glu Thr Tyr Met Gly Glu Trp Lys Asn Asp Lys Arg Asn Gly
 305                 310                 315                 320
 Phe Gly Val Ser Glu Arg Ser Asn Gly Met Lys Tyr Glu Gly Glu Trp
                 325                 330                 335    
 Ala Asn Asn Lys Arg His Gly Tyr Gly Cys Thr Val Phe Pro Asp Gly
             340                 345                 350        
 Ser Lys Glu Glu Gly Lys Tyr Lys Asn Asn Ile Leu Val Arg Gly Ile
         355                 360                 365            
 Arg Lys Gln Leu Ile Pro Ile Arg His Thr Lys Thr Arg Glu Lys Val
     370                 375                 380                
 Asp Arg Ala Ile Glu Gly Ala Gln Arg Ala Ala Ala Met Ala Arg Thr
 385                 390                 395                 400
 Lys Val Glu Ile Ala Asn Ser Arg Asn Val Gln Lys Val Glu Glu Gln
                 405                 410                 415    
 Leu
    



      <210> 851
      <211> 536
      <212> PRT
      <213> Homo sapiens


      <400> 851
 Met Ala Thr Pro Asp Ala Gly Leu Pro Gly Ala Glu Gly Val Glu Pro
   1               5                  10                  15    
 Ala Pro Trp Ala Gln Leu Glu Ala Pro Ala Arg Leu Leu Leu Gln Ala
              20                  25                  30        
 Leu Gln Ala Gly Pro Glu Gly Ala Arg Arg Gly Leu Gly Val Leu Arg
          35                  40                  45            
 Ala Leu Gly Ser Arg Gly Trp Glu Pro Phe Asp Trp Gly Arg Leu Leu
      50                  55                  60                
 Glu Ala Leu Cys Arg Glu Glu Pro Val Val Gln Gly Pro Asp Gly Arg
  65                  70                  75                  80
 Leu Glu Leu Lys Pro Leu Leu Leu Arg Leu Pro Arg Ile Cys Gln Arg
                  85                  90                  95    
 Asn Leu Met Ser Leu Leu Met Ala Val Arg Pro Ser Leu Pro Glu Ser
             100                 105                 110        
 Gly Leu Leu Ser Val Leu Gln Ile Ala Gln Gln Asp Leu Ala Pro Asp
         115                 120                 125            
 Pro Asp Ala Trp Leu Arg Ala Leu Gly Glu Leu Leu Arg Arg Asp Leu
     130                 135                 140                
 Gly Val Gly Thr Ser Met Glu Gly Ala Ser Pro Leu Ser Glu Arg Cys
 145                 150                 155                 160
 Gln Arg Gln Leu Gln Ser Leu Cys Arg Gly Leu Gly Leu Gly Gly Arg
                 165                 170                 175    
 Arg Leu Lys Ser Pro Gln Ala Pro Asp Pro Glu Glu Glu Glu Asn Arg
             180                 185                 190        
 Asp Ser Gln Gln Pro Gly Lys Arg Arg Lys Asp Ser Glu Glu Glu Ala
         195                 200                 205            
 Ala Ser Pro Glu Gly Lys Arg Val Pro Lys Arg Leu Arg Cys Trp Glu
     210                 215                 220                
 Glu Glu Glu Asp His Glu Lys Glu Arg Pro Glu His Lys Ser Leu Glu
 225                 230                 235                 240
 Ser Leu Ala Asp Gly Gly Ser Ala Ser Pro Ile Lys Asp Gln Pro Val
                 245                 250                 255    
 Met Ala Val Lys Thr Gly Glu Asp Gly Ser Asn Leu Asp Asp Ala Lys
             260                 265                 270        
 Gly Leu Ala Glu Ser Leu Glu Leu Pro Lys Ala Ile Gln Asp Gln Leu
         275                 280                 285            
 Pro Arg Leu Gln Gln Leu Leu Lys Thr Leu Glu Glu Gly Leu Glu Gly
     290                 295                 300                
 Leu Glu Asp Ala Pro Pro Val Glu Leu Gln Leu Leu His Glu Cys Ser
 305                 310                 315                 320
 Pro Ser Gln Met Asp Leu Leu Cys Ala Gln Leu Gln Leu Pro Gln Leu
                 325                 330                 335    
 Ser Asp Leu Gly Leu Leu Arg Leu Cys Thr Trp Leu Leu Ala Leu Ser
             340                 345                 350        
 Pro Asp Leu Ser Leu Ser Asn Ala Thr Val Leu Thr Arg Ser Leu Phe
         355                 360                 365            
 Leu Gly Arg Ile Leu Ser Leu Thr Ser Ser Ala Ser Arg Leu Leu Thr
     370                 375                 380                
 Thr Ala Leu Thr Ser Phe Cys Ala Lys Tyr Thr Tyr Pro Val Cys Ser
 385                 390                 395                 400
 Ala Leu Leu Asp Pro Val Leu Gln Ala Pro Gly Thr Gly Pro Ala Gln
                 405                 410                 415    
 Thr Glu Leu Leu Cys Cys Leu Val Lys Met Glu Ser Leu Glu Pro Asp
             420                 425                 430        
 Ala Gln Val Leu Met Leu Gly Gln Ile Leu Glu Leu Pro Trp Lys Glu
         435                 440                 445            
 Glu Thr Phe Leu Val Leu Gln Ser Leu Leu Glu Arg Gln Val Glu Met
     450                 455                 460                
 Thr Pro Glu Lys Phe Ser Val Leu Met Glu Lys Leu Cys Lys Lys Gly
 465                 470                 475                 480
 Leu Ala Ala Thr Thr Ser Met Ala Tyr Ala Lys Leu Met Leu Thr Val
                 485                 490                 495    
 Met Thr Lys Tyr Gln Ala Asn Ile Thr Glu Thr Gln Arg Leu Gly Leu
             500                 505                 510        
 Ala Met Ala Leu Glu Pro Asn Thr Thr Phe Leu Arg Lys Ser Leu Lys
         515                 520                 525            
 Ala Ala Leu Lys His Leu Gly Pro
     530                 535    



      <210> 852
      <211> 87
      <212> PRT
      <213> Homo sapiens


      <400> 852
 Met Leu Leu Pro Ala Leu Lys Gln His Ser Val Leu Lys Thr Ser Trp
   1               5                  10                  15    
 Gln Ala Pro Gly Ser Asn Thr Gln Leu Pro Asn Met Met Leu Ile Leu
              20                  25                  30        
 His Glu Phe Ala Thr Gln Phe Ser Arg Val Cys Thr Pro Pro Leu Trp
          35                  40                  45            
 Ala Gly Glu Pro Gly Pro Gly Leu Arg Arg Leu Gln Ala Leu Ala Asp
      50                  55                  60                
 Val Ala Leu His Asn Asn Gly Asn Glu Lys Pro Thr Lys Arg Gly Tyr
  65                  70                  75                  80
 Gly Leu Gly Gly Arg Arg Arg
                  85        



      <210> 853
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 853
 Met Leu Ser Arg Ile Leu Glu Gly Asp Leu Trp Ala Ser Ser Gly Gln
   1               5                  10                  15    
 Arg Gln Gly Gly Pro Gln Thr Gly His Arg Met Lys Trp Ala Val Glu
              20                  25                  30        
 Cys Val Phe Leu Trp Pro Pro Asn Ser His Ser Ala Ser Gln Ile Ser
          35                  40                  45            
 Gly Asn Thr Ser Leu Phe Leu Gln Ala His Pro Gly Arg Arg Ile Gln
      50                  55                  60                
 Glu Ser Ser Phe Pro
  65                



      <210> 854
      <211> 306
      <212> PRT
      <213> Homo sapiens


      <400> 854
 Met Ser Ser Ser Tyr Trp Ser Glu Thr Ser Ser Ser Ser Cys Gly Thr
   1               5                  10                  15    
 Gln Gln Leu Pro Glu Val Leu Gln Cys Gln Pro Gln His Tyr His Cys
              20                  25                  30        
 Tyr His Gln Ser Ser Gln Ala Gln Gln Pro Pro Glu Lys Asn Val Val
          35                  40                  45            
 Tyr Glu Arg Val Arg Thr Tyr Ser Gly Pro Met Asn Lys Val Val Gln
      50                  55                  60                
 Ala Leu Asp Pro Phe Asn Ser Arg Glu Val Leu Ser Pro Leu Lys Thr
  65                  70                  75                  80
 Thr Ser Ser Tyr Gln Asn Leu Val Trp Ser Asp His Ser Gln Glu Leu
                  85                  90                  95    
 His Ser Pro Thr Leu Lys Ile Ser Thr Cys Ala Pro Ser Thr Leu His
             100                 105                 110        
 Ile Thr Gln Asn Thr Glu Gln Glu Leu His Ser Pro Thr Val Lys Leu
         115                 120                 125            
 Thr Thr Tyr Pro Gln Thr Thr Ile Arg Lys Tyr Val Val Gln Asn Pro
     130                 135                 140                
 Glu Gln Glu Pro Leu Ser Gln Phe Leu Arg Gly Ser His Phe Phe Pro
 145                 150                 155                 160
 Gly Asn Asn Val Ile Tyr Glu Lys Thr Ile Arg Lys Val Glu Lys Leu
                 165                 170                 175    
 Asn Thr Asp Gln Gly Cys His Pro Gln Ala Gln Cys His His His Ile
             180                 185                 190        
 Ile Gln Gln Pro Gln Val Ile His Ser Ala His Trp Gln Gln Pro Asp
         195                 200                 205            
 Ser Ser Gln Gln Ile Gln Ala Ile Thr Gly Asn Asn Pro Ile Ser Thr
     210                 215                 220                
 His Ile Gly Asn Glu Leu Cys His Ser Gly Ser Ser Gln Ile Cys Glu
 225                 230                 235                 240
 Gln Val Ile Ile Gln Asp Asp Gly Pro Glu Lys Leu Asp Pro Arg Tyr
                 245                 250                 255    
 Phe Gly Glu Leu Leu Ala Asp Leu Ser Arg Lys Asn Thr Asp Leu Tyr
             260                 265                 270        
 His Cys Leu Leu Glu His Leu Gln Arg Ile Gly Arg Lys Gln Ser Leu
         275                 280                 285            
 Ser Ser Thr Tyr Thr Ile Arg His Gly Ile Gln Thr Lys Arg Thr Gly
     290                 295                 300                
 Ile Leu
 305    



      <210> 855
      <211> 224
      <212> PRT
      <213> Homo sapiens


      <400> 855
 Met Ser Ser Asp Phe Glu Gly Tyr Glu Gln Asp Phe Ala Val Leu Thr
   1               5                  10                  15    
 Ala Glu Ile Thr Ser Lys Ile Ala Arg Val Pro Arg Leu Pro Pro Asp
              20                  25                  30        
 Glu Lys Lys Gln Met Val Ala Asn Val Glu Lys Gln Leu Glu Glu Ala
          35                  40                  45            
 Lys Glu Leu Leu Glu Gln Met Asp Leu Glu Val Arg Glu Ile Pro Pro
      50                  55                  60                
 Gln Ser Arg Gly Met Tyr Ser Asn Arg Met Arg Ser Tyr Lys Gln Glu
  65                  70                  75                  80
 Met Gly Lys Leu Glu Thr Asp Phe Lys Arg Ser Arg Ile Ala Tyr Ser
                  85                  90                  95    
 Asp Glu Val Arg Asn Glu Leu Leu Gly Asp Asp Gly Asn Ser Ser Glu
             100                 105                 110        
 Asn Gln Leu Ile Lys Leu Arg Glu Glu Arg Ala His Leu Leu Asp Asn
         115                 120                 125            
 Thr Glu Arg Leu Glu Arg Ser Ser Arg Arg Leu Glu Ala Gly Tyr Gln
     130                 135                 140                
 Ile Ala Val Glu Thr Glu Gln Ile Gly Gln Glu Met Leu Glu Asn Leu
 145                 150                 155                 160
 Ser His Asp Arg Glu Lys Ile Gln Arg Ala Arg Glu Arg Leu Arg Glu
                 165                 170                 175    
 Thr Asp Ala Asn Leu Gly Lys Ser Ser Arg Ile Leu Thr Gly Met Leu
             180                 185                 190        
 Arg Arg Ile Ile Gln Asn Arg Ile Leu Leu Val Ile Leu Gly Ile Ile
         195                 200                 205            
 Val Val Ile Thr Ile Leu Met Ala Ile Thr Phe Ser Val Arg Arg His
     210                 215                 220                





      <210> 856
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 856
 Met Leu Leu Leu Phe Pro Leu Gln Glu Arg Pro Gln Gln Asp Ser Phe
   1               5                  10                  15    
 Ile Arg Leu Leu Leu Ala Trp Gly Thr Arg Leu Glu Leu Thr Leu Asp
              20                  25                  30        
 Ile Lys Gly Gly Ile Met Trp Leu Leu Lys Pro Ser Ala His Ser Pro
          35                  40                  45            
 Val His Ile Leu Val Leu Leu Phe Pro Arg Gly Trp Ser Gln Pro Gly
      50                  55                  60                
 Thr His Lys Arg Gln Ile Leu Val Asn Ala Ala Ser Leu Pro Gly Gly
  65                  70                  75                  80
 Cys Leu Leu Pro Trp Ile Trp Ser Gly Ala Ala Leu Arg Phe
                  85                  90                



      <210> 857
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 857
 Met Met Phe Ser Gly Phe Asn Ala Asp Tyr Glu Ala Ser Ser Ser Arg
   1               5                  10                  15    
 Cys Ser Ser Ala Ser Pro Ala Gly Asp Ser Leu Ser Tyr Tyr His Ser
              20                  25                  30        
 Pro Ala Asp Ser Phe Ser Ser Met Gly Ser Pro Val Asn Ala Gln Val
          35                  40                  45            
 Arg Leu Ala Ser Arg Arg Arg Gly Ala Gly Gly Leu Gly Ser Arg Arg
      50                  55                  60                
 Arg Arg His Arg Ala Gly Arg Ser Ser Arg
  65                  70                



      <210> 858
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 858
 Met Gly Ser Ser Ser Glu Ala Ser Phe Arg Ser Ala Gln Ala Ser Cys
   1               5                  10                  15    
 Ser Gly Ala Arg Arg Gln Gly Leu Gly Arg Gly Asp Gln Asn Leu Ser
              20                  25                  30        
 Val Met Pro Pro Asn Gly Arg Ala Gln Thr His Thr Pro Gly Trp Val
          35                  40                  45            
 Ser Asp Pro Leu Val Leu Gly Ala Gln Val His Gly Gly Cys Arg Gly
      50                  55                  60                
 Ile Glu Ala Leu Ser Val Ser Ser Gly Ser Trp Ser Ser Ala Thr Val
  65                  70                  75                  80
 Trp Ile Leu Thr Val Gln
                  85    



      <210> 859
      <211> 172
      <212> PRT
      <213> Homo sapiens


      <400> 859
 Met Ala Leu Ala Leu Pro Cys Lys Leu Thr Ile Pro Gln Arg Glu Leu
   1               5                  10                  15    
 Gly Gly Ala Asp Gly Ala Ser Asp Ser Thr Asp Ser Pro Ala Ser Cys
              20                  25                  30        
 Gln Lys Lys Ser Ala Gly Cys His Thr Leu Tyr Leu Ser Ser Val Ser
          35                  40                  45            
 Val Glu Thr Leu Thr Gly Ala Leu Ala Val Gln Lys Ala Ile Ser Thr
      50                  55                  60                
 Thr Phe Glu Arg Asp Ile Leu Pro Thr Pro Thr Val Val His Phe Lys
  65                  70                  75                  80
 Val Thr Glu Gln Gly Ile Thr Leu Thr Asp Val Gln Arg Lys Val Phe
                  85                  90                  95    
 Phe Arg Arg His Tyr Pro Leu Thr Thr Leu Arg Phe Cys Gly Met Asp
             100                 105                 110        
 Pro Glu Gln Arg Lys Trp Gln Lys Tyr Cys Lys Pro Ser Trp Ile Phe
         115                 120                 125            
 Gly Phe Val Ala Lys Ser Gln Thr Glu Pro Gln Glu Asn Val Cys His
     130                 135                 140                
 Leu Phe Ala Glu Tyr Asp Met Val Gln Pro Ala Ser Gln Val Ile Gly
 145                 150                 155                 160
 Leu Val Thr Ala Leu Leu Gln Asp Ala Glu Arg Met
                 165                 170        



      <210> 860
      <211> 63
      <212> PRT
      <213> Homo sapiens


      <400> 860
 Met Ala Ser Tyr Ser Gly Phe Ser Gly Leu Leu Glu Ile Arg Tyr Gly
   1               5                  10                  15    
 Pro Gly His Arg Ser Cys Leu Pro Gln Phe Ala Phe Phe Pro Gln Pro
              20                  25                  30        
 Pro Leu Pro Arg Pro Arg Ile Cys Met Trp Lys Tyr Leu Asp Val His
          35                  40                  45            
 Ser Met His Gln Leu Glu Lys Thr Thr Asn Ala Glu Met Arg Glu
      50                  55                  60            



      <210> 861
      <211> 78
      <212> PRT
      <213> Homo sapiens


      <400> 861
 Met Ile Val Arg Ile Ile Asn Thr Asp Ile Lys Arg Gly Val Gln His
   1               5                  10                  15    
 Thr Glu Lys Arg Ala Pro Val Thr Asn Ile Glu Arg Arg Phe Ser Thr
              20                  25                  30        
 Lys Glu Leu Asp Gln Ile Asn Gly Ser Lys Gly Cys Ala Tyr Phe Gln
          35                  40                  45            
 Lys Gly Asn Ile Tyr Ile Ser Arg Cys Ser Ala Glu Ile Phe Trp Ile
      50                  55                  60                
 Cys Glu Lys Thr Ala Ala Pro Val Lys Thr Glu Asp Leu Asp
  65                  70                  75            



      <210> 862
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 862
 Met Val His Cys Pro His Glu Leu Leu Gln Met Pro Leu Ser Leu Phe
   1               5                  10                  15    
 Ser Gln Arg Ser Trp Val Thr Gln Cys Leu Asp Thr Trp Lys Thr Cys
              20                  25                  30        
 Thr Leu Ile Thr Gln Arg His Leu Ala Ser Asp His Leu Pro Ser Glu
          35                  40                  45            
 Phe Leu Leu Val Gln Leu Gly Tyr His Pro Leu Thr His Gln Ala Ala
      50                  55                  60                
 Pro His Leu Pro Leu Leu Leu Leu Trp Gln Val Phe Pro Ala Tyr Gln
  65                  70                  75                  80
 Glu Gln Gly Phe Ser Cys Lys Gly Gln Leu Leu Leu Gly Leu Leu Val
                  85                  90                  95    
 Ser Thr Asp Asn Ile Phe Leu Pro Ile Leu Gly Gln Ala Pro Gln Thr
             100                 105                 110        
 His Val Gly Ile Leu Glu Glu Leu Phe Pro Lys Ser Phe Glu
         115                 120                 125    



      <210> 863
      <211> 261
      <212> PRT
      <213> Homo sapiens


      <400> 863
 Met Asp Ser Ser Ala Val Ile Thr Gln Ile Ser Lys Glu Glu Ala Arg
   1               5                  10                  15    
 Gly Pro Leu Arg Gly Lys Gly Asp Gln Lys Ser Ala Ala Ser Gln Lys
              20                  25                  30        
 Pro Arg Ser Arg Gly Ile Leu His Ser Leu Phe Cys Cys Val Cys Arg
          35                  40                  45            
 Asp Asp Gly Glu Ala Leu Pro Ala His Ser Gly Ala Pro Leu Leu Val
      50                  55                  60                
 Glu Glu Asn Gly Ala Ile Pro Lys Gln Thr Pro Val Gln Tyr Pro Leu
  65                  70                  75                  80
 Pro Glu Ala Lys Ala Gln Asp Ser Asp Lys Ile Cys Val Val Ile Asp
                  85                  90                  95    
 Leu Asp Glu Thr Leu Val His Ser Ser Phe Lys Pro Val Asn Asn Ala
             100                 105                 110        
 Asp Phe Ile Ile Pro Val Glu Ile Asp Gly Val Val His Gln Val Tyr
         115                 120                 125            
 Val Leu Lys Arg Pro His Val Asp Glu Phe Leu Gln Arg Met Gly Glu
     130                 135                 140                
 Leu Phe Glu Cys Val Leu Phe Thr Ala Ser Leu Ala Lys Tyr Ala Asp
 145                 150                 155                 160
 Pro Val Ala Asp Leu Leu Asp Lys Trp Gly Ala Phe Arg Ala Arg Leu
                 165                 170                 175    
 Phe Arg Glu Ser Cys Val Phe His Arg Gly Asn Tyr Val Lys Asp Leu
             180                 185                 190        
 Ser Arg Leu Gly Arg Asp Leu Arg Arg Val Leu Ile Leu Asp Asn Ser
         195                 200                 205            
 Pro Ala Ser Tyr Val Phe His Pro Asp Asn Ala Val Pro Val Ala Ser
     210                 215                 220                
 Trp Phe Asp Asn Met Ser Asp Thr Glu Leu His Asp Leu Leu Pro Phe
 225                 230                 235                 240
 Phe Glu Gln Leu Ser Arg Val Asp Asp Val Tyr Ser Val Leu Arg Gln
                 245                 250                 255    
 Pro Arg Pro Gly Ser
             260    



      <210> 864
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 864
 Met Ser Ala His Met Ser Gly Leu Glu Ile Met Asp Glu Asp Gln Leu
   1               5                  10                  15    
 Ile Lys Asp Val Leu Asp Lys Phe Leu Asn Cys His Glu Gln Thr Tyr
              20                  25                  30        
 Asp Glu Glu Phe Leu Asn Thr Phe Thr His Leu Ser Gln Glu Asp His
          35                  40                  45            
 Val Ser Lys Arg Gly Val Phe Gly Thr Asp Ser Ser Glu Asn Ile Phe
      50                  55                  60                
 Thr Ser Ala Lys Val Thr His Lys Asn Glu Ala Asp Asp Tyr His Leu
  65                  70                  75                  80
 Arg Asn Lys Thr Ile Phe Leu Arg Thr Ser Ser Gln Cys Leu Glu Glu
                  85                  90                  95    
 Gln Ile Cys Cys Cys Phe Gln Glu Lys Trp Ser Arg Met
             100                 105                



      <210> 865
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 865
 Met Leu Lys His Leu Lys Gly Phe Leu Gly Ile Ile Glu Phe Cys Lys
   1               5                  10                  15    
 Leu Gly Ile Pro Arg Tyr Ser Glu Ile Thr Arg Pro Leu Tyr His Leu
              20                  25                  30        
 Ile Lys Glu Met Gln Ala Ala Lys Thr Gln Ser Leu Thr Trp Glu Pro
          35                  40                  45            
 Gly Ala Gln Lys Gly Phe Asn Gln Leu Lys Gln Ala Leu Leu Lys Ala
      50                  55                  60                
 Pro Ala Leu Ser Leu Pro Ile Gly Lys Thr Phe Ser Leu Tyr Val Ala
  65                  70                  75                  80
 Lys Arg Lys Arg Met Ala Leu Gly Val Leu Thr Gln Ala Gln Gly Pro
                  85                  90                  95    
 Ala Gln Gln Pro Val Gly Tyr Leu Ser Lys Glu Leu Glu Leu Met Ala
             100                 105                 110        
 Lys Val Arg Pro Ala Cys Leu
         115                



      <210> 866
      <211> 474
      <212> PRT
      <213> Homo sapiens


      <400> 866
 Met Ala Gln His Asp Phe Val Pro Ala Trp Leu Asn Phe Ser Thr Pro
   1               5                  10                  15    
 Gln Ser Ala Lys Ser Pro Thr Ala Thr Phe Glu Lys His Gly Glu His
              20                  25                  30        
 Leu Pro Arg Gly Glu Gly Arg Phe Gly Val Ser Arg Arg Arg His Asn
          35                  40                  45            
 Ser Ser Asp Gly Phe Phe Asn Asn Gly Pro Leu Arg Thr Ala Gly Asp
      50                  55                  60                
 Ser Trp His Gln Pro Ser Leu Phe Arg His Asp Ser Val Asp Ser Gly
  65                  70                  75                  80
 Val Ser Lys Gly Ala Tyr Ala Gly Ile Thr Gly Asn Pro Ser Gly Trp
                  85                  90                  95    
 His Ser Ser Ser Arg Gly His Asp Gly Met Ser Gln Arg Ser Gly Gly
             100                 105                 110        
 Gly Thr Gly Asn His Arg His Trp Asn Gly Ser Phe His Ser Arg Lys
         115                 120                 125            
 Gly Cys Ala Phe Gln Glu Lys Pro Pro Met Glu Ile Arg Glu Glu Lys
     130                 135                 140                
 Lys Glu Asp Lys Val Glu Lys Leu Gln Phe Glu Glu Glu Asp Phe Pro
 145                 150                 155                 160
 Ser Leu Asn Pro Glu Ala Gly Lys Gln His Gln Pro Cys Arg Pro Ile
                 165                 170                 175    
 Gly Thr Pro Ser Gly Val Trp Glu Asn Pro Pro Ser Ala Lys Gln Pro
             180                 185                 190        
 Ser Lys Met Leu Val Ile Lys Lys Val Ser Lys Glu Asp Pro Ala Ala
         195                 200                 205            
 Ala Phe Ser Ala Ala Phe Thr Ser Pro Gly Ser His His Ala Asn Gly
     210                 215                 220                
 Asn Lys Leu Ser Ser Val Val Pro Ser Val Tyr Lys Asn Leu Val Pro
 225                 230                 235                 240
 Lys Pro Val Pro Pro Pro Ser Lys Pro Asn Ala Trp Lys Ala Asn Arg
                 245                 250                 255    
 Met Glu His Lys Ser Gly Ser Leu Ser Ser Ser Arg Glu Ser Ala Phe
             260                 265                 270        
 Thr Ser Pro Ile Ser Val Thr Lys Pro Val Val Leu Ala Ser Gly Ala
         275                 280                 285            
 Ala Leu Ser Ser Pro Lys Glu Ser Pro Ser Ser Thr Thr Pro Pro Ile
     290                 295                 300                
 Glu Ile Ser Ser Ser Arg Leu Thr Lys Leu Thr Arg Arg Thr Thr Asp
 305                 310                 315                 320
 Arg Lys Ser Glu Phe Leu Lys Thr Leu Lys Asp Asp Arg Asn Gly Asp
                 325                 330                 335    
 Phe Ser Glu Asn Arg Asp Cys Asp Lys Leu Glu Asp Leu Glu Asp Asn
             340                 345                 350        
 Ser Thr Pro Glu Pro Lys Glu Asn Gly Glu Glu Gly Cys His Gln Asn
         355                 360                 365            
 Gly Leu Ala Leu Pro Val Val Glu Glu Gly Glu Val Leu Ser His Ser
     370                 375                 380                
 Leu Glu Ala Glu His Arg Leu Leu Lys Ala Met Gly Trp Gln Glu Tyr
 385                 390                 395                 400
 Pro Glu Asn Asp Glu Asn Cys Leu Pro Leu Thr Glu Asp Glu Leu Lys
                 405                 410                 415    
 Glu Phe His Met Lys Thr Glu Gln Leu Arg Arg Asn Gly Phe Gly Lys
             420                 425                 430        
 Asn Gly Phe Leu Gln Ser Arg Ser Ser Ser Leu Phe Ser Pro Trp Arg
         435                 440                 445            
 Ser Thr Cys Lys Ala Glu Phe Glu Asp Ser Asp Thr Glu Thr Ser Ser
     450                 455                 460                
 Ser Glu Thr Ser Asp Asp Asp Ala Trp Lys
 465                 470                



      <210> 867
      <211> 234
      <212> PRT
      <213> Homo sapiens


      <400> 867
 Met Asn Pro Val Pro His Trp Gly Glu Val Phe Leu Leu Val Gly Gly
   1               5                  10                  15    
 Glu Gly Glu His Leu Ala Ser Gln Gly Thr Thr Pro Ala Arg Asp His
              20                  25                  30        
 Arg Val Gly Ile Ser Pro Ala Ser Gln Gln Ala Gln Pro Glu Ser Trp
          35                  40                  45            
 Arg Arg Arg Gln Arg Asp Lys Gly Val Asp Pro Glu Lys Ala Pro Ser
      50                  55                  60                
 Leu Thr Arg Gln Ser Gln Asn Pro Pro Ser Leu Thr Ala Pro Leu Gly
  65                  70                  75                  80
 Met Pro Ser Ala Cys Ser Cys Leu Pro Cys Gly Pro Ala Pro Glu Ala
                  85                  90                  95    
 Ala Ile Ile Leu Ala Gly Pro Pro Thr Ala Leu Thr Val Leu Pro Lys
             100                 105                 110        
 Gly Thr Gly Leu Lys Lys Ser Lys Arg Leu Leu Leu Glu Ser Leu Met
         115                 120                 125            
 Arg Arg Arg Ile Ala His Leu Lys Trp Gly Leu Pro Arg Arg Ile Leu
     130                 135                 140                
 Glu Ser Tyr Phe Leu Phe Asn Phe Leu Gly Ser Cys Ser Leu Thr Leu
 145                 150                 155                 160
 Ala Gly Ala Arg Leu Ser Gly Leu Asn Thr Gly Gln Glu Leu Gln Ala
                 165                 170                 175    
 Gln Gln Glu Arg Tyr Cys Glu Ala Gln Gly Ser Pro Pro Gly Leu Lys
             180                 185                 190        
 Ser Pro Glu Arg Phe Gln Arg Val Gln Arg Pro Asp Arg Lys Ser Ser
         195                 200                 205            
 Lys Leu Pro Ile Gln Ala Arg Ala Leu Glu Arg Asn Arg Pro His Met
     210                 215                 220                
 Ser Glu Pro Ile Lys His Phe His Pro Ala
 225                 230                



      <210> 868
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 868
 Met Gly Ala Gln Ser Gly Pro Leu Pro Gln Thr Glu Pro Trp Pro Leu
   1               5                  10                  15    
 Lys Val Asp Ser Glu Ala Ala Ala Pro Pro Ala Ala Ser Val Ser Ser
              20                  25                  30        
 Gln Ala Arg Ser Gly Lys Gly Phe Lys Ser Lys Pro Pro Gly Ser Cys
          35                  40                  45            
 Val Arg Ser Thr Gln Gln Gly Phe Lys Val Ser Asn Trp Phe Gly Thr
      50                  55                  60                
 Gln Pro Gly Pro Pro Lys Glu Thr Lys Ala Gly Thr Gly Trp Gly Gln
  65                  70                  75                  80
 Ala Gly Leu Ala Gly Ser Cys Ala Asp Pro Pro Arg Val Pro Trp Glu
                  85                  90                  95    
 Ala Val Gly Leu Ala Val Ala Ala Val Ser Cys Ser Gln Ala Ser Pro
             100                 105                 110        
 Ala Ser Pro Gly Ser Gly Arg Arg Ala Ser Ala His Phe Ile Ser His
         115                 120                 125            
 Arg Leu Arg Arg Pro Gly Ala Pro Pro Ser Thr His Asn Lys Glu Arg
     130                 135                 140                
 Asp Ser Phe Arg Thr Ala Phe Ile Trp Ile Thr Asp
 145                 150                 155    



      <210> 869
      <211> 239
      <212> PRT
      <213> Homo sapiens


      <400> 869
 Met Gln Asp Pro Asn Thr Asp Thr Glu Trp Asn Asp Ile Leu Asp Lys
   1               5                  10                  15    
 Lys Gly Ile Leu Pro Thr Lys Glu Ser Ile Lys Glu Ser Glu Glu Lys
              20                  25                  30        
 Ala Glu Glu Glu Gln His Ile Leu Gln Gln Ser Val Val Thr Thr Tyr
          35                  40                  45            
 Glu Asp Met Thr Leu Glu Glu Leu Glu Asp His Glu Asp Glu Phe Asn
      50                  55                  60                
 Glu Glu Asp Glu His Ala Ile Glu Met Tyr Arg Trp Gln Arg Leu Ala
  65                  70                  75                  80
 Glu Gly Lys Ala Ile Lys Leu Lys Asn Lys Phe Gly Glu Val Leu Glu
                  85                  90                  95    
 Ile Ser Gly Lys Tyr Tyr Val Gln Glu Val Thr Lys Ala Ser Glu Gly
             100                 105                 110        
 Leu Trp Val Ile Leu His Leu Cys Lys Arg Gly Ile Pro Leu Cys Ala
         115                 120                 125            
 Leu Ile Asn Gln His Leu Ser Gly Leu Ala Arg Arg Phe Pro Asp Val
     130                 135                 140                
 Lys Phe Ile Lys Ala Asn Ser Thr Thr Arg Ile Pro Asn Tyr Pro Asp
 145                 150                 155                 160
 Arg Asn Leu Pro Met Val Phe Val Tyr Leu Glu Gly Asp Ile Lys Ala
                 165                 170                 175    
 Gln Leu Ile Gly Pro Leu Val Phe Gly Gly Met Asn Leu Thr Arg Asp
             180                 185                 190        
 Glu Leu Gly Trp Lys Leu Ser Glu Ser Arg Ala Val Lys Thr Asp Leu
         195                 200                 205            
 Glu Glu Asn Pro Lys Lys Pro Ile Glu Gly Val Leu Leu Ser Ser Val
     210                 215                 220                
 Gln Ser Ser Val Pro Met Arg Arg Asp Ser Asp Ser Lys Gly Asp
 225                 230                 235                



      <210> 870
      <211> 442
      <212> PRT
      <213> Homo sapiens


      <400> 870
 Met Pro Cys Gly Lys Gln Gly Asn Leu Gln Val Pro Gly Ser Lys Val
   1               5                  10                  15    
 Leu Pro Gly Leu Gly Glu Gly Cys Lys Glu Met Trp Leu Arg Lys Val
              20                  25                  30        
 Ile Tyr Gly Gly Glu Val Trp Gly Lys Ser Pro Glu Pro Glu Phe Pro
          35                  40                  45            
 Ser Leu Val Asn Leu Cys Gln Ser Trp Lys Ile Asn Asn Leu Met Ser
      50                  55                  60                
 Thr Val His Ser Asp Glu Ala Gly Met Leu Ser Tyr Phe Leu Phe Glu
  65                  70                  75                  80
 Glu Leu Met Arg Cys Asp Lys Asp Ser Met Pro Asp Gly Asn Leu Ser
                  85                  90                  95    
 Glu Glu Glu Lys Leu Phe Leu Ser Tyr Phe Pro Leu His Lys Phe Glu
             100                 105                 110        
 Leu Glu Gln Asn Ile Lys Glu Leu Asn Thr Leu Ala Asp Gln Val Asp
         115                 120                 125            
 Thr Thr His Glu Leu Leu Thr Lys Thr Ser Leu Val Ala Ser Ser Ser
     130                 135                 140                
 Gly Ala Val Ser Gly Val Met Asn Ile Leu Gly Leu Ala Leu Ala Pro
 145                 150                 155                 160
 Val Thr Ala Gly Gly Ser Leu Met Leu Ser Ala Thr Gly Thr Gly Leu
                 165                 170                 175    
 Gly Ala Ala Ala Ala Ile Thr Asn Ile Val Thr Asn Val Leu Glu Asn
             180                 185                 190        
 Arg Ser Asn Ser Ala Ala Arg Asp Lys Ala Ser Arg Leu Gly Pro Leu
         195                 200                 205            
 Thr Thr Ser His Glu Ala Phe Gly Gly Ile Asn Trp Ser Glu Ile Glu
     210                 215                 220                
 Ala Ala Gly Phe Cys Val Asn Lys Cys Val Lys Ala Ile Gln Gly Ile
 225                 230                 235                 240
 Lys Asp Leu His Ala Tyr Gln Met Ala Lys Ser Asn Ser Gly Phe Met
                 245                 250                 255    
 Ala Met Val Lys Asn Phe Val Ala Lys Arg His Ile Pro Phe Trp Thr
             260                 265                 270        
 Ala Arg Gly Val Gln Arg Ala Phe Glu Gly Thr Thr Leu Ala Met Thr
         275                 280                 285            
 Asn Gly Ala Trp Val Met Gly Ala Ala Gly Ala Gly Phe Leu Leu Met
     290                 295                 300                
 Lys Asp Met Ser Ser Phe Leu Gln Ser Trp Lys His Leu Glu Asp Gly
 305                 310                 315                 320
 Ala Arg Thr Glu Thr Ala Glu Glu Leu Arg Ala Leu Ala Lys Lys Leu
                 325                 330                 335    
 Glu Gln Glu Leu Asp Arg Leu Thr Gln His His Arg His Leu Pro Gln
             340                 345                 350        
 Lys Ala Ser Gln Thr Cys Ser Ser Ser Arg Gly Arg Ala Val Arg Gly
         355                 360                 365            
 Ser Arg Val Val Lys Pro Glu Gly Ser Arg Ser Pro Leu Pro Trp Pro
     370                 375                 380                
 Val Val Glu His Gln Pro Arg Leu Gly Pro Gly Val Ala Leu Arg Thr
 385                 390                 395                 400
 Pro Lys Arg Thr Val Ser Ala Pro Arg Met Leu Gly His Gln Pro Ala
                 405                 410                 415    
 His Gln His Gln Gln Glu Arg Gly Asp Arg Pro Arg Glu Asp Thr Asp
             420                 425                 430        
 Asn Glu Lys Ser Trp Ser Pro Cys His His
         435                 440        



      <210> 871
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 871
 Met Gln Ser Val Thr Ser Val Glu Thr Gln Arg Ala Thr Asp Val Cys
   1               5                  10                  15    
 Ser Ala Cys Ala Ala Ala Ala Ala Arg Ser Glu Pro Pro Lys Glu Thr
              20                  25                  30        
 Ala Asp Cys Pro Gly Leu Leu Leu Glu Pro Gly His Val Leu Leu Lys
          35                  40                  45            
 Lys Met Pro Phe Thr Gln Gly Ile Ser Cys Tyr Leu Met Trp Lys Asp
      50                  55                  60                
 Thr Pro Met Ser Pro Phe Gly Pro Leu Trp Gly Pro Gly Asn Ala Ala
  65                  70                  75                  80
 Val Gly Ser Arg Pro Gln Ala Gly Pro Ala Leu Ser Ser Ala Arg Val
                  85                  90                  95    
 Cys Lys Ser Glu Gln
             100    



      <210> 872
      <211> 1013
      <212> PRT
      <213> Homo sapiens


      <400> 872
 Met Lys Leu Ser Asp Leu Ala Gln Ser Asp Pro Glu Val Arg Arg Ala
   1               5                  10                  15    
 Ala Val His Cys Met Ala Asn Leu Cys Leu Ser Val Pro Gly Gln Pro
              20                  25                  30        
 Tyr Leu Glu Glu Pro Tyr Gln Asn Val Cys Phe Gln Ala Phe Leu Thr
          35                  40                  45            
 Ile Leu Gln Ser Pro Lys Ser Ser Asp Met Asp Asp Ile Thr Phe Cys
      50                  55                  60                
 Met Leu Leu Gln Asn Ala Leu Lys Gly Ile Gln Ser Leu Leu Asn Gly
  65                  70                  75                  80
 Gly Arg Met Lys Leu Thr Gln Thr Asp Glu Leu Gly Ala Leu Leu Ala
                  85                  90                  95    
 Val Leu Lys Lys Phe Met Phe His Gly Leu Pro Gly Leu Asn Ile Glu
             100                 105                 110        
 Met Pro Thr Val Leu Tyr Pro Thr Pro Leu Pro Gln Tyr Asp Gly Arg
         115                 120                 125            
 Thr Pro Ile Lys Pro Gln Gln Ser Glu Ser Ser Ala Ser Arg Pro Thr
     130                 135                 140                
 Leu Asn Lys Lys Lys Lys Ser Glu Val Lys Pro Lys Lys Ile Gln Gln
 145                 150                 155                 160
 Gly Glu Glu Glu Glu Lys Glu Ser Ser Gly Glu Ile Glu Ala Ala Pro
                 165                 170                 175    
 Val Thr Gly Thr Gly Arg Val Asn Leu His Glu Gly Asn Thr Trp Cys
             180                 185                 190        
 Pro Ser Ser Leu Gly Val Gln Ser Leu Pro Leu Asp Gly Ser Gly Ala
         195                 200                 205            
 Ala Glu Lys Asp Gly Val Ser Ser Ser Phe Ser Ser Ser Ser Trp Lys
     210                 215                 220                
 Arg Val Ser Ser Ser Glu Ser Asp Phe Ser Asp Ala Glu Gly Gly Met
 225                 230                 235                 240
 Gln Ser Lys Met Arg Ser Tyr Gln Ala Lys Val Arg Gln Gly Ala Leu
                 245                 250                 255    
 Val Cys Phe Leu Ser Thr Ile Lys Ser Ile Glu Lys Lys Val Leu Tyr
             260                 265                 270        
 Gly Tyr Trp Ser Ala Phe Ile Pro Asp Thr Pro Glu Leu Gly Ser Pro
         275                 280                 285            
 Gln Ser Val Ser Leu Met Thr Leu Thr Leu Lys Asp Pro Ser Pro Lys
     290                 295                 300                
 Thr Arg Ala Cys Ala Leu Gln Val Leu Ser Ala Ile Leu Glu Gly Ser
 305                 310                 315                 320
 Lys Gln Phe Leu Ser Val Ala Glu Asp Thr Ser Asp His Arg Arg Ala
                 325                 330                 335    
 Phe Thr Pro Phe Ser Val Met Ile Ala Cys Ser Ile Arg Glu Leu His
             340                 345                 350        
 Arg Cys Leu Leu Leu Ala Leu Val Ala Glu Ser Ser Ser Gln Thr Val
         355                 360                 365            
 Thr Gln Ile Ile Lys Cys Leu Ala Asn Leu Val Ser Asn Ala Pro Tyr
     370                 375                 380                
 Asp Arg Leu Lys Leu Ser Leu Leu Thr Lys Val Trp Asn Gln Ile Lys
 385                 390                 395                 400
 Pro Tyr Ile Arg His Lys Asp Val Asn Val Arg Val Ser Ser Leu Thr
                 405                 410                 415    
 Leu Leu Gly Ala Ile Val Ser Thr His Ala Pro Leu Pro Glu Val Gln
             420                 425                 430        
 Leu Leu Leu Gln Gln Pro Cys Ser Ser Gly Leu Gly Asn Ser Asn Ser
         435                 440                 445            
 Ala Thr Pro His Leu Ser Pro Pro Asp Trp Trp Lys Lys Thr Pro Ala
     450                 455                 460                
 Gly Pro Ser Leu Glu Glu Thr Ser Val Ser Ser Pro Lys Gly Ser Ser
 465                 470                 475                 480
 Glu Pro Cys Trp Leu Ile Arg Leu Cys Ile Ser Ile Val Val Leu Pro
                 485                 490                 495    
 Lys Glu Asp Ser Cys Ser Gly Ser Asp Ala Gly Ser Ala Ala Gly Ser
             500                 505                 510        
 Thr Tyr Glu Pro Ser Pro Met Arg Leu Glu Ala Leu Gln Val Leu Thr
         515                 520                 525            
 Leu Leu Ala Arg Gly Tyr Phe Ser Met Thr Gln Ala Tyr Leu Met Glu
     530                 535                 540                
 Leu Gly Glu Val Ile Cys Lys Cys Met Gly Glu Ala Asp Pro Ser Ile
 545                 550                 555                 560
 Gln Leu His Gly Ala Lys Leu Leu Glu Glu Leu Gly Thr Gly Leu Ile
                 565                 570                 575    
 Gln Gln Tyr Lys Pro Asp Ser Thr Ala Ala Pro Asp Gln Arg Ala Pro
             580                 585                 590        
 Val Phe Leu Val Val Met Phe Trp Thr Met Met Leu Asn Gly Pro Leu
         595                 600                 605            
 Pro Arg Ala Leu Gln Asn Ser Glu His Pro Thr Leu Gln Ala Ser Ala
     610                 615                 620                
 Cys Asp Ala Leu Ser Ser Ile Leu Pro Glu Ala Phe Ser Asn Leu Pro
 625                 630                 635                 640
 Asn Asp Arg Gln Met Leu Cys Ile Thr Val Leu Leu Gly Leu Asn Asp
                 645                 650                 655    
 Ser Lys Asn Arg Leu Val Lys Ala Ala Thr Ser Arg Ala Leu Gly Val
             660                 665                 670        
 Tyr Val Leu Phe Pro Cys Leu Arg Gln Asp Val Ile Phe Val Ala Asp
         675                 680                 685            
 Ala Ala Asn Ala Ile Leu Met Ser Leu Glu Asp Lys Ser Leu Asn Val
     690                 695                 700                
 Arg Ala Lys Ala Ala Trp Ser Leu Gly Asn Leu Thr Asp Thr Leu Ile
 705                 710                 715                 720
 Val Asn Met Glu Thr Pro Asp Pro Ser Phe Gln Glu Glu Phe Ser Gly
                 725                 730                 735    
 Leu Leu Leu Leu Lys Met Leu Arg Ser Ala Ile Glu Ala Ser Lys Asp
             740                 745                 750        
 Lys Asp Lys Val Lys Ser Asn Ala Val Arg Ala Leu Gly Asn Leu Leu
         755                 760                 765            
 His Phe Leu Gln Pro Ser His Ile Glu Lys Pro Thr Phe Ala Glu Ile
     770                 775                 780                
 Ile Glu Glu Ser Ile Gln Ala Leu Ile Ser Thr Val Leu Thr Glu Ala
 785                 790                 795                 800
 Ala Met Lys Val Arg Trp Asn Ala Cys Tyr Ala Met Gly Asn Val Phe
                 805                 810                 815    
 Lys Asn Pro Ala Leu Pro Leu Gly Thr Ala Pro Trp Thr Ser Gln Ala
             820                 825                 830        
 Tyr Asn Ala Leu Thr Ser Val Val Thr Ser Cys Lys Asn Phe Lys Val
         835                 840                 845            
 Arg Ile Arg Ser Ala Ala Ala Leu Ser Val Pro Gly Lys Arg Glu Gln
     850                 855                 860                
 Tyr Gly Ser Val Asp Gln Tyr Ala Arg Ile Trp Asn Ala Leu Val Thr
 865                 870                 875                 880
 Ala Leu Gln Lys Ser Glu Asp Thr Ile Asp Phe Leu Glu Phe Lys Tyr
                 885                 890                 895    
 Cys Val Ser Leu Arg Thr Gln Ile Cys Gln Ala Leu Ile His Leu Leu
             900                 905                 910        
 Ser Leu Ala Ser Ala Ser Asp Leu Pro Cys Met Lys Glu Thr Leu Glu
         915                 920                 925            
 Leu Ser Gly Asn Met Val Gln Ser Tyr Ile Leu Gln Phe Leu Lys Ser
     930                 935                 940                
 Gly Ala Glu Gly Asp Asp Thr Gly Ala Pro His Ser Pro Gln Glu Arg
 945                 950                 955                 960
 Asp Gln Met Val Arg Met Ala Leu Lys His Met Gly Ser Ile Gln Ala
                 965                 970                 975    
 Pro Thr Gly Asp Thr Ala Arg Arg Ala Ile Met Gly Phe Leu Glu Glu
             980                 985                 990        
 Ile Leu Ala Val Cys Phe Asp Ser Ser Gly Ser Gln Gly Ala Leu Pro
         995                1000                1005            
 Gly Leu Thr Asn Gln
    1010            



      <210> 873
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 873
 Met His Gln Asn Ile Tyr Asp Tyr Ile His Val Asp Asp Arg Gln Asp
   1               5                  10                  15    
 Phe Cys Arg Gln Leu His Trp Ala Met Asp Pro Pro Gln Val Val Phe
              20                  25                  30        
 Gly Gln Pro Pro Pro Leu Glu Thr Gly Asp Asp Ala Ile Leu Gly Arg
          35                  40                  45            
 Leu Leu Arg Ala Gln Glu Trp Gly Thr Gly Thr Pro Thr Glu Tyr Ser
      50                  55                  60                
 Ala Phe Leu Thr Arg Cys Phe Ile Cys Arg Val Arg Cys Leu Leu Asp
  65                  70                  75                  80
 Ser Thr Ser Gly Phe Leu Thr Met Gln Phe Gln Gly Lys Leu Lys Phe
                  85                  90                  95    
 Leu Phe Gly Gln Lys Lys Lys Ala Pro Ser Gly Ala Met Leu Pro Pro
             100                 105                 110        
 Arg Leu Ser Leu Phe Cys Ile Ala Ala Pro Val Leu Leu Pro Ser Ala
         115                 120                 125            
 Ala Glu Met Lys Met Arg Ser Ala Leu Leu Arg Ala Lys Pro Arg Ala
     130                 135                 140                
 Asp Thr Ala Ala Thr Ala Asp Ala Lys Cys Gly Leu Asp
 145                 150                 155        



      <210> 874
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 874
 Met Glu Ile Leu Ser Ser Pro Trp Lys Glu Ser Leu Phe Phe Pro Ser
   1               5                  10                  15    
 Ser Cys Thr Ser Pro Gln Val Glu Ser His Trp Pro Ala Gly Pro Met
              20                  25                  30        
 Pro Ile Pro Glu Gln Tyr Cys Asn Trp Ser Pro Ala Val Thr Cys Pro
          35                  40                  45            
 Val Thr Ala Gly Arg Trp Gly Trp Ala Ser Tyr Pro Lys Glu Ser Pro
      50                  55                  60                
 Gly Ala Val Pro Arg Arg Glu Asn Gly Cys Gly Ala Glu Gln Thr Val
  65                  70                  75                  80
 Asp Val Tyr Leu Thr Gln Pro Asp Lys Thr Ala Cys Lys Asn Gln Ala
                  85                  90                  95    
 Tyr Gly Pro Ala Pro Leu Cys Arg Pro Thr Leu Tyr Thr Pro Glu Met
             100                 105                 110        
 Pro Phe Leu Ser Leu Ala Asn Pro His Ser Pro Phe Gln Ser Gln Leu
         115                 120                 125            
 Ile
    



      <210> 875
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 875
 Met Thr Tyr Glu Ala Gln Phe Phe Gly Phe Thr Pro Gln Thr Cys Met
   1               5                  10                  15    
 Leu Arg Ile Tyr Ile Ala Phe Gln Asp Tyr Leu Phe Glu Val Met Gln
              20                  25                  30        
 Ala Val Glu Gln Val Ile Leu Lys Lys Leu Asp Gly Ile Pro Asp Cys
          35                  40                  45            
 Asp Ile Ser Pro Val Gln Ile Arg Lys Cys Thr Glu Lys Phe Leu Cys
      50                  55                  60                
 Phe Met Lys Gly His Phe Asp Asn Leu Phe Ser Lys Met Glu Gln Leu
  65                  70                  75                  80
 Phe Leu Gln Leu Ile Leu Arg Ile Pro Ser Asn Ile Leu Leu Pro Glu
                  85                  90                  95    
 Asp Lys Cys Lys Glu Thr Pro Tyr Ser Glu Glu Asp Phe Gln His Leu
             100                 105                 110        
 Gln Lys Glu Ile Glu Gln Leu Gln Glu Lys Tyr Lys Thr Glu Leu Cys
         115                 120                 125            
 Thr Lys Gln Ala Leu Leu Ala Glu Leu Glu Glu Gln Lys Ile Val Gln
     130                 135                 140                
 Ala Lys Leu Lys Gln Thr Leu Thr Phe Phe Asp Glu Leu His Asn Val
 145                 150                 155                 160
 Gly Arg Asp His Gly Thr Ser Asp Phe Arg Glu Ser Leu Val Ser Leu
                 165                 170                 175    
 Val Gln Asn Ser Arg Lys Leu Gln Asn Ile Arg Asp Asn Val Glu Lys
             180                 185                 190        
 Glu Ser Lys Arg Leu Lys Ile Ser
         195                 200



      <210> 876
      <211> 104
      <212> PRT
      <213> Homo sapiens


      <400> 876
 Met Thr Phe Arg Ala Thr Asp Ser Glu Phe Asp Leu Thr Asn Ile Glu
   1               5                  10                  15    
 Glu Tyr Ala Glu Asn Ser Ala Leu Ser Arg Leu Asn Asn Ile Lys Ala
              20                  25                  30        
 Lys Gln Arg Val Ser Tyr Val Thr Ser Thr Glu Asn Glu Ser Asp Thr
          35                  40                  45            
 Gln Ile Leu Thr Phe Arg His Ile Thr Lys Ala Gln Glu Lys Thr Arg
      50                  55                  60                
 Lys Arg Gln Gln Pro Ile Lys Leu Glu Pro Leu Val Ser Ser Lys Thr
  65                  70                  75                  80
 Ile Val Leu Ala Ser Val Ala Thr Glu Glu Val Val Lys Leu Leu Trp
                  85                  90                  95    
 Arg Ile Glu Val Met Ser Arg Leu
             100                



      <210> 877
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 877
 Met His Ser Arg Ser Pro Phe His Trp Asn Ser Thr Leu Thr Met Arg
   1               5                  10                  15    
 Asn Thr Ser Ser Ile Gln Trp Thr Phe Val His Trp Lys Arg Leu Ala
              20                  25                  30        
 Ser Val Lys Glu Pro His His Ser Ser Pro Gln Leu Arg Cys Leu Arg
          35                  40                  45            
 Leu Phe Pro His Cys Leu Cys Ser Ile Thr Ser Trp Thr
      50                  55                  60    



      <210> 878
      <211> 67
      <212> PRT
      <213> Homo sapiens


      <400> 878
 Met Val Leu Glu Asp Met Leu Leu Phe Pro Glu Gly Gly Arg Gln Pro
   1               5                  10                  15    
 Asp Asp Gly Gly Thr Ile Asn Asp Ile Ser Val Leu Gly Val Thr Cys
              20                  25                  30        
 Leu Gly Ala Gln Ala Asp His Phe Thr Gln Thr Pro Leu Asp Pro Gly
          35                  40                  45            
 Ser Gln Val Leu Val Trp Val Asp Trp Glu Trp Arg Phe Asp His Met
      50                  55                  60                
 Gln Gln His
  65        



      <210> 879
      <211> 211
      <212> PRT
      <213> Homo sapiens


      <400> 879
 Met Ala Glu Ala Ser Ser Ala Asn Leu Gly Ser Gly Cys Glu Glu Lys
   1               5                  10                  15    
 Arg His Glu Gly Ser Ser Ser Glu Ser Val Pro Pro Gly Thr Thr Ile
              20                  25                  30        
 Ser Arg Val Lys Leu Leu Asp Thr Met Val Asp Thr Phe Leu Gln Lys
          35                  40                  45            
 Leu Val Ala Ala Gly Ser Tyr Gln Arg Phe Thr Asp Cys Tyr Lys Cys
      50                  55                  60                
 Phe Tyr Gln Leu Gln Pro Ala Met Thr Gln Gln Ile Tyr Asp Lys Phe
  65                  70                  75                  80
 Ile Ala Gln Leu Gln Thr Ser Ile Arg Glu Glu Ile Ser Asp Ile Lys
                  85                  90                  95    
 Glu Glu Gly Asn Leu Glu Ala Val Leu Asn Ala Leu Asp Lys Ile Val
             100                 105                 110        
 Glu Glu Gly Lys Val Arg Lys Glu Pro Ala Trp Arg Pro Ser Gly Ile
         115                 120                 125            
 Pro Glu Lys Asp Leu His Ser Val Met Ala Pro Tyr Phe Leu Gln Gln
     130                 135                 140                
 Arg Asp Thr Leu Arg Arg His Val Gln Lys Gln Glu Ala Glu Asn Gln
 145                 150                 155                 160
 Gln Leu Ala Asp Ala Val Leu Ala Gly Arg Arg Gln Val Glu Glu Leu
                 165                 170                 175    
 Gln Leu Gln Val Gln Ala Gln Gln Gln Ala Trp Gln Val Arg Ser Pro
             180                 185                 190        
 Ala Val Gln Ser Pro Ala Lys Val Gln Pro Leu Cys Pro Ser Arg Arg
         195                 200                 205            
 Ala Ala Arg
     210    



      <210> 880
      <211> 73
      <212> PRT
      <213> Homo sapiens


      <400> 880
 Met Asp Trp Met Trp Arg Val Thr Arg Arg Gly Glu Leu Thr Ser Cys
   1               5                  10                  15    
 Leu Ser Gly Ala Thr Tyr Gln Phe Phe Tyr Gly Val Ser Thr Pro His
              20                  25                  30        
 Ala Leu Ala Thr Tyr Leu Arg Lys Leu Leu Asp Leu Lys Ser Glu Ser
          35                  40                  45            
 Phe Lys Gln Met Asn Val Cys Phe Val Leu His Leu Pro Trp Glu Ile
      50                  55                  60                
 Leu Asn Ile Tyr Arg Asn Arg Val Ser
  65                  70            



      <210> 881
      <211> 659
      <212> PRT
      <213> Homo sapiens


      <400> 881
 Met Ser Leu Pro Pro Glu Lys Ala Ser Glu Leu Lys Gln Leu Ile His
   1               5                  10                  15    
 Gln Gln Leu Ser Lys Met Asp Val His Gly Arg Ile Arg Glu Ile Leu
              20                  25                  30        
 Ala Glu Thr Ile Arg Glu Glu Leu Ala Pro Asp Gln Gln His Leu Ser
          35                  40                  45            
 Thr Glu Asp Leu Ile Lys Ala Leu Arg Arg Arg Gly Ile Ile Asp Asp
      50                  55                  60                
 Val Met Lys Glu Leu Asn Phe Val Thr Asp Ser Val Glu Gln Glu Leu
  65                  70                  75                  80
 Pro Ser Ser Pro Lys Gln Pro Ile Cys Phe Asp Arg Gln Ser Thr Leu
                  85                  90                  95    
 Lys Lys Thr Asn Ile Asp Pro Thr Arg Arg Tyr Leu Tyr Leu Gln Val
             100                 105                 110        
 Leu Gly Gly Lys Ala Phe Leu Glu His Leu Gln Glu Pro Glu Pro Leu
         115                 120                 125            
 Pro Gly Gln Val Cys Ser Thr Phe Thr Leu Cys Leu His Tyr Arg Asn
     130                 135                 140                
 Gln Arg Phe Arg Ser Lys Pro Val Pro Cys Ala Cys Glu Pro Asp Phe
 145                 150                 155                 160
 His Asp Gly Phe Leu Leu Glu Val His Arg Glu Ser Leu Gly Asp Gly
                 165                 170                 175    
 Thr Arg Met Ala Asp Ser Thr Thr Met Leu Ser Ile Ser Asp Pro Ile
             180                 185                 190        
 His Met Val Leu Ile Lys Thr Asp Ile Phe Gly Glu Thr Thr Leu Val
         195                 200                 205            
 Ala Ser Tyr Phe Leu Glu Trp Arg Ser Val Leu Gly Ser Glu Asn Gly
     210                 215                 220                
 Val Thr Ser Leu Thr Val Glu Leu Met Gly Val Gly Thr Glu Ser Lys
 225                 230                 235                 240
 Val Ser Val Gly Ile Leu Asn Ile Lys Leu Glu Met Tyr Pro Pro Leu
                 245                 250                 255    
 Asn Gln Thr Leu Ser Gln Glu Val Val Asn Thr Gln Leu Ala Leu Glu
             260                 265                 270        
 Arg Gln Lys Thr Ala Glu Lys Glu Arg Leu Phe Leu Val Tyr Ala Lys
         275                 280                 285            
 Gln Trp Trp Arg Glu Tyr Leu Gln Ile Arg Pro Ser His Asn Ser Arg
     290                 295                 300                
 Leu Val Lys Ile Phe Ala Gln Asp Glu Asn Gly Ile Asn Arg Pro Val
 305                 310                 315                 320
 Cys Ser Tyr Val Lys Pro Leu Arg Ala Gly Arg Leu Leu Asp Thr Pro
                 325                 330                 335    
 Arg Gln Ala Ala Arg Phe Val Asn Val Leu Gly Tyr Glu Arg Ala Pro
             340                 345                 350        
 Val Ile Gly Gly Gly Gly Lys Gln Glu Gln Trp Cys Thr Leu Leu Ala
         355                 360                 365            
 Phe Leu Cys Arg Asn Lys Gly Asp Cys Glu Asp His Ala Asn Leu Leu
     370                 375                 380                
 Cys Ser Leu Leu Leu Gly Tyr Gly Leu Glu Ala Phe Val Cys Val Gly
 385                 390                 395                 400
 Thr Lys Ala Lys Gly Val Pro His Ala Trp Val Met Thr Cys Gly Thr
                 405                 410                 415    
 Asp Gly Ala Ile Thr Phe Trp Glu Ser Leu Thr Gly His Arg Tyr Ile
             420                 425                 430        
 His Lys Pro Thr Asn Pro Asp Glu Pro Pro Val Ala Glu Gln Pro Lys
         435                 440                 445            
 Pro Leu Tyr Pro Tyr Arg Thr Ile Gly Cys Val Phe Asn His Gln Met
     450                 455                 460                
 Phe Leu Gly Asn Cys Gln Pro Ser Asp Ala Val Glu Thr Cys Val Phe
 465                 470                 475                 480
 Asp Leu Asn Asp Glu Ser Lys Trp Lys Pro Met Ser Glu Glu Ala Ile
                 485                 490                 495    
 Lys Ser Val Cys Ala Pro Gly Ala Thr Thr Ser Leu Pro Pro Phe Pro
             500                 505                 510        
 Pro Leu Cys Ala Ser Thr Ile Asp Ala Ser Val Thr Ser Asn Glu Ile
         515                 520                 525            
 Glu Met Gln Leu Arg Leu Leu Val Ser Glu His Arg Lys Asp Leu Gly
     530                 535                 540                
 Leu Thr Thr Val Trp Glu Asp Gln Leu Ser Tyr Leu Leu Ser Pro Ala
 545                 550                 555                 560
 Leu Ala Ser Tyr Glu Phe Glu Arg Thr Thr Ser Ile Ser Ala Gly Asn
                 565                 570                 575    
 Glu Glu Phe Gln Asp Ala Ile Arg Arg Ala Val Pro Asp Gly His Thr
             580                 585                 590        
 Phe Lys Gly Phe Pro Ile His Phe Val Tyr Arg Asn Ala Arg Arg Ala
         595                 600                 605            
 Phe Ala Thr Cys Leu Arg Ser Pro Phe Cys Glu Glu Ile Ile Cys Cys
     610                 615                 620                
 Arg Gly Asp Gln Val Arg Leu Ala Val Arg Val Arg Val Phe Thr Tyr
 625                 630                 635                 640
 Pro Glu Ser Ala Cys Ala Val Trp Ile Met Phe Ala Cys Lys Tyr Arg
                 645                 650                 655    
 Ser Val Leu
            



      <210> 882
      <211> 188
      <212> PRT
      <213> Homo sapiens


      <400> 882
 Met Ser Arg Gln Ala Asn Arg Gly Thr Glu Ser Lys Lys Met Ser Ser
   1               5                  10                  15    
 Glu Leu Phe Thr Leu Thr Tyr Gly Ala Leu Val Thr Gln Leu Cys Lys
              20                  25                  30        
 Asp Tyr Glu Asn Asp Glu Asp Val Asn Lys Gln Leu Asp Lys Ile Leu
          35                  40                  45            
 Phe Ser Asn Phe Leu Pro Arg Gly Phe Asn Ile Gly Val Arg Leu Ile
      50                  55                  60                
 Glu Asp Phe Leu Ala Arg Ser Asn Val Gly Arg Cys His Asp Phe Arg
  65                  70                  75                  80
 Glu Thr Ala Asp Val Ile Ala Lys Val Ala Phe Lys Met Tyr Leu Gly
                  85                  90                  95    
 Ile Thr Pro Ser Ile Thr Asn Trp Ser Pro Ala Gly Asp Glu Phe Ser
             100                 105                 110        
 Leu Ile Leu Glu Asn Asn Pro Leu Val Asp Phe Val Glu Leu Pro Asp
         115                 120                 125            
 Asn His Ser Ser Leu Ile Tyr Ser Asn Leu Leu Cys Gly Val Leu Arg
     130                 135                 140                
 Gly Ala Leu Glu Met Val Gln Met Ala Val Glu Ala Lys Phe Val Gln
 145                 150                 155                 160
 Asp Thr Leu Lys Gly Asp Gly Val Thr Glu Ile Arg Met Arg Phe Ile
                 165                 170                 175    
 Arg Ala Ile Glu Asp Asn Leu Pro Ala Gly Glu Glu
             180                 185            



      <210> 883
      <211> 180
      <212> PRT
      <213> Homo sapiens


      <400> 883
 Met His Ser Leu Ala Tyr Gln His Asn Thr Gly Ile His Pro Gly Ala
   1               5                  10                  15    
 Met Ile Asn Arg Ala Gln Pro Lys Ala Glu Pro Gly His Asp Lys Ile
              20                  25                  30        
 Arg Asp Ala Val Arg Ala Trp Ser Ser Ser Leu Asp Asn Gln Asp Val
          35                  40                  45            
 Val Ser Ala Leu Ile Ile Asn Glu Tyr Arg Glu Gln Gly Gly Thr Ala
      50                  55                  60                
 Ile Ser Phe Pro Glu Asp Ile Ser Arg Ala Arg Gln Lys Leu Phe Arg
  65                  70                  75                  80
 Phe Leu Asp Asn Arg Phe Asp Ser Asp Gln Tyr Arg Glu Asn Val Arg
                  85                  90                  95    
 Glu Leu Thr Pro Ala Ile Met Ala Val Leu Pro Val Glu Phe Arg Thr
             100                 105                 110        
 Arg Leu Ala Pro Gln Asn Asp Thr Met Ser Leu Ile Ala Ser Ala Met
         115                 120                 125            
 Lys Glu Cys Ser Glu Ala Lys Gln Ala Val Leu Leu Asn Ala Pro Glu
     130                 135                 140                
 His Gln Lys Met Lys Glu Val Ser Glu Gly Ile Ala Ser Leu Phe Arg
 145                 150                 155                 160
 Leu Met Pro Glu Gln Val Gly Pro Leu Met Thr Met Val Thr Ser Met
                 165                 170                 175    
 Leu Gly Val Ile
             180



      <210> 884
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 884
 Met Ala Val Ser Gly Arg Leu Gly Leu Arg Gln Gly Ala Gly Pro Thr
   1               5                  10                  15    
 Trp Gly Ser Leu Val Leu Gly Gln Leu Ser Val Ser Pro Arg Pro Val
              20                  25                  30        
 Thr Thr Gly Phe Pro Arg Lys Glu Val Arg Tyr Gln Gly Pro Trp Ala
          35                  40                  45            
 Gly Pro Gly Val Gly Gln Gly Gly Ala Ser Thr Gly Glu Gly Gln Gly
      50                  55                  60                
 Ala Leu Pro Glu Pro His Pro Ala Pro Ala Thr Gly Val Arg Glu Cys
  65                  70                  75                  80
 Leu Gly Val Pro Leu Gly Ala Ala
                  85            



      <210> 885
      <211> 481
      <212> PRT
      <213> Homo sapiens


      <400> 885
 Met Tyr Asp Ala Glu Arg Gly Trp Ser Leu Ser Phe Ala Gly Cys Gly
   1               5                  10                  15    
 Phe Leu Gly Phe Tyr His Val Gly Ala Thr Arg Cys Leu Ser Glu His
              20                  25                  30        
 Ala Pro His Leu Leu Arg Asp Ala Arg Met Leu Phe Gly Ala Ser Ala
          35                  40                  45            
 Gly Ala Leu His Cys Val Gly Val Leu Ser Gly Ile Pro Leu Glu Gln
      50                  55                  60                
 Thr Leu Gln Val Leu Ser Asp Leu Val Arg Lys Ala Arg Ser Arg Asn
  65                  70                  75                  80
 Ile Gly Ile Phe His Pro Ser Phe Asn Leu Ser Lys Phe Leu Arg Gln
                  85                  90                  95    
 Gly Leu Cys Lys Cys Leu Pro Ala Asn Val His Gln Leu Ile Ser Gly
             100                 105                 110        
 Lys Ile Gly Ile Ser Leu Thr Arg Val Ser Asp Gly Glu Asn Val Leu
         115                 120                 125            
 Val Ser Asp Phe Arg Ser Lys Asp Glu Val Val Asp Ala Leu Val Cys
     130                 135                 140                
 Ser Cys Phe Ile Pro Phe Tyr Ser Gly Leu Ile Pro Pro Ser Phe Arg
 145                 150                 155                 160
 Gly Val Arg Tyr Val Asp Gly Gly Val Ser Asp Asn Val Pro Phe Ile
                 165                 170                 175    
 Asp Ala Lys Thr Thr Ile Thr Val Ser Pro Phe Tyr Gly Glu Tyr Asp
             180                 185                 190        
 Ile Cys Pro Lys Val Lys Ser Thr Asn Phe Leu His Val Asp Ile Thr
         195                 200                 205            
 Lys Leu Ser Leu Arg Leu Cys Thr Gly Asn Leu Tyr Leu Leu Ser Arg
     210                 215                 220                
 Ala Phe Val Pro Pro Asp Leu Lys Val Leu Gly Glu Ile Cys Leu Arg
 225                 230                 235                 240
 Gly Tyr Leu Asp Ala Phe Arg Phe Leu Glu Glu Lys Gly Ile Cys Asn
                 245                 250                 255    
 Arg Pro Gln Pro Gly Leu Lys Ser Ser Ser Glu Gly Met Asp Pro Glu
             260                 265                 270        
 Val Ala Met Pro Ser Trp Ala Asn Met Ser Leu Asp Ser Ser Pro Glu
         275                 280                 285            
 Ser Ala Ala Leu Ala Val Arg Leu Glu Gly Asp Glu Leu Leu Asp His
     290                 295                 300                
 Leu Arg Leu Ser Ile Leu Pro Trp Asp Glu Ser Ile Leu Asp Thr Leu
 305                 310                 315                 320
 Ser Pro Arg Leu Ala Thr Ala Leu Ser Glu Glu Met Lys Asp Lys Gly
                 325                 330                 335    
 Gly Tyr Met Ser Lys Ile Cys Asn Leu Leu Pro Ile Arg Ile Met Ser
             340                 345                 350        
 Tyr Val Met Leu Pro Cys Thr Leu Pro Val Glu Ser Ala Ile Ala Ile
         355                 360                 365            
 Val Gln Arg Leu Val Thr Trp Leu Pro Asp Met Pro Asp Asp Val Leu
     370                 375                 380                
 Trp Leu Gln Trp Val Thr Ser Gln Val Phe Thr Arg Val Leu Met Cys
 385                 390                 395                 400
 Leu Leu Pro Ala Ser Arg Ser Gln Met Pro Val Ser Ser Gln Gln Ala
                 405                 410                 415    
 Ser Pro Cys Thr Pro Glu Gln Asp Trp Pro Cys Trp Thr Pro Cys Ser
             420                 425                 430        
 Pro Glu Gly Cys Pro Ala Glu Thr Lys Ala Glu Ala Thr Pro Arg Ser
         435                 440                 445            
 Ile Leu Arg Ser Ser Leu Asn Phe Phe Leu Gly Asn Lys Val Pro Ala
     450                 455                 460                
 Gly Ala Glu Gly Leu Ser Thr Phe Pro Ser Phe Ser Leu Glu Lys Ser
 465                 470                 475                 480
 Leu
    



      <210> 886
      <211> 39
      <212> PRT
      <213> Homo sapiens


      <400> 886
 Met Pro Glu Ala Val Glu Gln Ser Ala His Leu Phe Val Thr Trp Ser
   1               5                  10                  15    
 Ser Gln Arg Ala Leu Ser His Pro Ala Pro Phe Leu Thr Arg Glu Lys
              20                  25                  30        
 Asn Pro Phe Leu Trp Lys Leu
          35                



      <210> 887
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 887
 Met Thr Ala Met Arg Asp Pro Ala Ser Ser Gln Tyr Arg Ser Phe Leu
   1               5                  10                  15    
 Phe Trp Arg Met Pro Ile Pro Glu Leu Asp Leu Ser Glu Leu Glu Arg
              20                  25                  30        
 Leu Gly Leu Ser His Thr Ala Thr Tyr Glu Val Lys Asp Ser Ser Gly
          35                  40                  45            
 Gly Lys Met Ile Gly Gln Ala Thr Ala Ala Asp Gln Glu Lys Asn Pro
      50                  55                  60                
 Glu Gly Asp Gly Leu Leu Glu Tyr Ser Thr Phe Asn Phe Trp Arg Ala
  65                  70                  75                  80
 Pro Ile Ala Ser Ile His Ser Phe Glu Leu Asp Leu Leu
                  85                  90            



      <210> 888
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 888
 Met Pro Thr Gly Lys Gln Leu Ala Asp Ile Gly Tyr Lys Thr Phe Ser
   1               5                  10                  15    
 Thr Ser Met Met Leu Leu Thr Val Tyr Gly Gly Tyr Leu Cys Ser Val
              20                  25                  30        
 Arg Val Tyr His Tyr Phe Gln Trp Gly Arg Ala Gln Arg Gln Ala Ala
          35                  40                  45            
 Lys Lys Gln Lys Thr Ser Gly Ile Met
      50                  55        



      <210> 889
      <211> 210
      <212> PRT
      <213> Homo sapiens


      <400> 889
 Met Glu Leu Glu Lys His Glu Lys Arg Ser Leu Leu Asn Lys Asn Leu
   1               5                  10                  15    
 Glu Glu Lys Leu Thr Val Ser Ala Gly Gly Ser Glu Ala Lys Pro Leu
              20                  25                  30        
 Ile Phe Thr Phe Val Pro Thr Val Arg Arg Leu Pro Thr His Thr Gln
          35                  40                  45            
 Leu Ala Asp Thr Ser Lys Phe Leu Val Lys Ile Pro Glu Glu Ser Ser
      50                  55                  60                
 Asp Lys Ser Pro Glu Thr Val Asn Arg Ser Lys Ser Asn Asp Tyr Leu
  65                  70                  75                  80
 Thr Leu Asn Ala Gly Ser Gln Gln Glu Arg Asp Gln Ala Lys Leu Thr
                  85                  90                  95    
 Cys Pro Ser Glu Val Ser Gly Thr Ile Leu Gln Glu Arg Glu Phe Glu
             100                 105                 110        
 Ala Asn Lys Leu Gln Gly Met Gln Gln Ser Asp Leu Phe Lys Ala Glu
         115                 120                 125            
 Tyr Val Leu Ile Val Asp Ser Glu Gly Glu Asp Glu Ala Ala Ser Arg
     130                 135                 140                
 Lys Val Glu Gln Gly Pro Pro Gly Gly Ile Gly Thr Ala Ala Val Arg
 145                 150                 155                 160
 Pro Lys Ser Leu Ala Ile Ser Ser Ser Leu Val Ser Asp Val Val Arg
                 165                 170                 175    
 Pro Lys Thr Gln Gly Thr Asp Leu Lys Thr Ser Ser His Pro Glu Met
             180                 185                 190        
 Leu His Gly Met Ala Pro Gln Gln Lys His Gly Gln Leu Phe Ser Ile
         195                 200                 205            
 Leu Thr
     210



      <210> 890
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 890
 Met Gly Gly Asn Gly Ser Thr Cys Lys Pro Asp Thr Glu Arg Gln Gly
   1               5                  10                  15    
 Thr Leu Ser Thr Ala Ala Pro Thr Thr Ser Pro Ala Pro Cys Leu Ser
              20                  25                  30        
 Asn His His Asn Lys Lys His Leu Ile Leu Ala Phe Cys Ala Gly Val
          35                  40                  45            
 Leu Leu Thr Leu Leu Leu Ile Ala Phe Ile Phe Leu Ile Ile Lys Ser
      50                  55                  60                
 Tyr Arg Lys Tyr His Ser Lys Pro Gln Ala Pro Asp Pro His Ser Asp
  65                  70                  75                  80
 Pro Pro Ala Lys Leu Ser Ser Ile Pro Gly Glu Ser Leu Thr Tyr Ala
                  85                  90                  95    
 Ser Thr Thr Phe Lys Leu Ser Glu Glu Lys Ser Asn His Leu Ala Glu
             100                 105                 110        
 Asn His Ser Ala Asp Phe Asp Pro Ile Val Tyr Ala Gln Ile Lys Val
         115                 120                 125            
 Thr Asn
     130



      <210> 891
      <211> 258
      <212> PRT
      <213> Homo sapiens


      <400> 891
 Met Phe Tyr Val Ala Glu Pro Lys Gln Val Pro His Ile Leu Cys Ser
   1               5                  10                  15    
 Pro Ser Met Lys Asn Ile Asn Pro Leu Thr Ala Met Ser Tyr Leu Arg
              20                  25                  30        
 Lys Leu Asp Thr Ser Gly Phe Ser Ser Ile Leu Val Thr Leu Thr Lys
          35                  40                  45            
 Ala Ala Val Ala Leu Lys Met Gly Asp Leu Asp Met His Arg Asn Glu
      50                  55                  60                
 Met Lys Ser His Ser Glu Met Lys Leu Val Cys Gly Phe Ile Leu Glu
  65                  70                  75                  80
 Pro Arg Leu Leu Ile Gln Gln Arg Lys Gly Gln Ile Val Pro Thr Glu
                  85                  90                  95    
 Leu Ala Leu His Leu Lys Glu Thr Gln Pro Gly Leu Leu Val Ala Ser
             100                 105                 110        
 Val Leu Gly Leu Gln Lys Asn Asn Lys Ile Gly Ile Glu Glu Ala Asp
         115                 120                 125            
 Ser Phe Phe Lys Val Leu Cys Ala Lys Asp Glu Asp Thr Ile Pro Gln
     130                 135                 140                
 Leu Leu Val Asp Phe Trp Glu Ala Gln Leu Val Ala Cys Leu Pro Asp
 145                 150                 155                 160
 Val Val Leu Gln Glu Leu Phe Phe Lys Leu Thr Ser Gln Tyr Ile Trp
                 165                 170                 175    
 Arg Leu Ser Lys Arg Gln Pro Pro Asp Thr Thr Pro Leu Arg Thr Ser
             180                 185                 190        
 Glu Asp Leu Ile Asn Ala Cys Ser His Tyr Gly Leu Ile Tyr Pro Trp
         195                 200                 205            
 Val His Val Val Ile Ser Ser Asp Ser Leu Ala Asp Lys Asn Tyr Thr
     210                 215                 220                
 Glu Asp Leu Ser Lys Leu Gln Leu Pro Leu Phe Arg Ser Trp Ser His
 225                 230                 235                 240
 Phe Gln Lys Thr Leu Leu Pro Ala Ser Val Ser Met Phe Cys Val Val
                 245                 250                 255    
 His Ala
        



      <210> 892
      <211> 437
      <212> PRT
      <213> Homo sapiens


      <400> 892
 Met Pro Lys Phe Lys Ala Ala Arg Gly Val Gly Gly Gln Glu Lys His
   1               5                  10                  15    
 Ala Pro Leu Ala Asp Gln Ile Leu Ala Gly Asn Ala Val Arg Ala Gly
              20                  25                  30        
 Val Arg Glu Lys Arg Arg Gly Arg Gly Thr Gly Glu Ala Glu Glu Glu
          35                  40                  45            
 Tyr Val Gly Pro Arg Leu Ser Arg Arg Ile Leu Gln Gln Ala Arg Gln
      50                  55                  60                
 Gln Gln Glu Glu Leu Glu Ala Glu His Gly Thr Gly Asp Lys Pro Ala
  65                  70                  75                  80
 Ala Pro Arg Glu Arg Thr Thr Arg Leu Gly Pro Arg Met Pro Gln Asp
                  85                  90                  95    
 Gly Ser Asp Asp Glu Asp Glu Glu Trp Pro Thr Leu Glu Lys Ala Ala
             100                 105                 110        
 Thr Met Thr Ala Ala Gly His His Ala Glu Val Val Val Asp Pro Glu
         115                 120                 125            
 Asp Glu Arg Ala Ile Glu Met Phe Met Asn Lys Asn Pro Pro Ala Arg
     130                 135                 140                
 Arg Thr Leu Ala Asp Ile Ile Met Glu Lys Leu Thr Glu Lys Gln Thr
 145                 150                 155                 160
 Glu Val Glu Thr Val Met Ser Glu Val Ser Gly Phe Pro Met Pro Gln
                 165                 170                 175    
 Leu Asp Pro Arg Val Leu Glu Val Tyr Arg Gly Val Arg Glu Val Leu
             180                 185                 190        
 Ser Lys Tyr Arg Ser Gly Lys Leu Pro Lys Ala Phe Lys Ile Ile Pro
         195                 200                 205            
 Ala Leu Ser Asn Trp Glu Gln Ile Leu Tyr Val Thr Glu Pro Glu Ala
     210                 215                 220                
 Trp Thr Ala Ala Ala Met Tyr Gln Ala Thr Arg Ile Phe Ala Ser Asn
 225                 230                 235                 240
 Leu Lys Glu Arg Met Ala Gln Arg Phe Tyr Asn Leu Val Leu Leu Pro
                 245                 250                 255    
 Arg Val Arg Asp Asp Val Ala Glu Tyr Lys Arg Leu Asn Phe His Leu
             260                 265                 270        
 Tyr Met Ala Leu Lys Lys Ala Leu Phe Lys Pro Gly Ala Trp Phe Lys
         275                 280                 285            
 Gly Ile Leu Ile Pro Leu Cys Glu Ser Gly Thr Cys Thr Leu Arg Glu
     290                 295                 300                
 Ala Ile Ile Val Gly Ser Ile Ile Thr Lys Cys Ser Ile Pro Val Leu
 305                 310                 315                 320
 His Ser Ser Ala Ala Met Leu Lys Ile Ala Glu Met Glu Tyr Ser Gly
                 325                 330                 335    
 Ala Asn Ser Ile Phe Leu Arg Leu Leu Leu Asp Lys Lys Tyr Ala Leu
             340                 345                 350        
 Pro Tyr Arg Val Leu Asp Ala Leu Val Phe His Phe Leu Gly Phe Arg
         355                 360                 365            
 Thr Glu Lys Arg Glu Leu Pro Val Leu Trp His Gln Cys Leu Leu Thr
     370                 375                 380                
 Leu Val Gln Arg Tyr Lys Ala Asp Leu Ala Thr Asp Gln Lys Glu Ala
 385                 390                 395                 400
 Leu Leu Glu Leu Leu Arg Leu Gln Pro His Pro Gln Leu Ser Pro Glu
                 405                 410                 415    
 Ile Arg Arg Glu Leu Gln Ser Ala Val Pro Arg Asp Val Glu Asp Val
             420                 425                 430        
 Pro Ile Thr Val Glu
         435        



      <210> 893
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 893
 Met Ser Gly Asp Gly Pro Gly Ser Trp Gly Leu Glu Gly Arg Gly Pro
   1               5                  10                  15    
 Ser Ala Leu Gly Ser Gln Gly Ala Leu Pro Ala Gln Pro Gly Leu Ser
              20                  25                  30        
 Trp Glu Pro Leu Ala Gln Arg Leu Ser Leu Ala Asn Leu Gly Gly Cys
          35                  40                  45            
 Val His Pro Ala Arg Pro Ser Cys Gly Leu His Ser Ser Pro Cys Ser
      50                  55                  60                
 Leu Leu Pro Arg Val Glu Ser Arg Val Cys Gly His Ser Leu Ala Ser
  65                  70                  75                  80
 Cys Thr Cys Ser Phe
                  85



      <210> 894
      <211> 168
      <212> PRT
      <213> Homo sapiens


      <400> 894
 Met Val Gly Gly Met Gln Glu Arg Glu Pro Ala Leu Thr Val Lys Leu
   1               5                  10                  15    
 Arg Leu Phe Pro Pro Lys Pro Ser Thr Pro Ala Gln Thr Gly Ser Trp
              20                  25                  30        
 Ala Leu Phe Cys Leu Ser Gln Pro His Ser Lys Pro Ile Pro Pro Ala
          35                  40                  45            
 Pro Pro Tyr Cys Asn Ser Pro His Ser His Thr Arg Ser Pro Leu Pro
      50                  55                  60                
 Pro Thr Tyr Pro Arg Thr Phe Ser Pro Leu Pro Ser Gln Leu Pro Ala
  65                  70                  75                  80
 Pro Ser Cys Phe Thr Lys Gly Glu Val Pro Gly His Leu Arg Val Ser
                  85                  90                  95    
 Leu Cys Gly Ala Gln Asn Leu Gln Gly Pro Leu Ser Met Pro Leu Val
             100                 105                 110        
 Pro Trp Thr Val Ser Leu Val His Leu Leu Ser Pro Ser Ile Leu Ser
         115                 120                 125            
 Gln Ser Thr Asp Phe Ser His Ser Ala Val Ser Val Gln Pro Tyr Pro
     130                 135                 140                
 Arg Asp Leu Asp Ala Trp Pro Pro Asn Leu Ala Leu Gly Tyr Pro Asp
 145                 150                 155                 160
 Ala Asn Gln Thr Pro Pro Ser Ser
                 165            



      <210> 895
      <211> 390
      <212> PRT
      <213> Homo sapiens


      <400> 895
 Met Glu Asp Pro Thr Leu Tyr Ile Val Glu Arg Pro Leu Pro Gly Tyr
   1               5                  10                  15    
 Pro Asp Ala Glu Ala Pro Glu Pro Ser Ser Ala Gly Ala Gln Ala Ala
              20                  25                  30        
 Glu Glu Pro Ser Gly Ala Gly Ser Glu Glu Leu Ile Lys Ser Asp Gln
          35                  40                  45            
 Val Asn Gly Val Leu Val Leu Ser Leu Leu Asp Lys Ile Ile Gly Ala
      50                  55                  60                
 Val Asp Gln Ile Gln Leu Thr Gln Ala Gln Leu Glu Glu Arg Gln Ala
  65                  70                  75                  80
 Glu Met Glu Gly Ala Val Gln Ser Ile Gln Gly Glu Leu Ser Lys Leu
                  85                  90                  95    
 Gly Lys Ala His Ala Thr Thr Ser Asn Thr Val Ser Lys Leu Leu Glu
             100                 105                 110        
 Lys Val Arg Lys Val Ser Val Asn Val Lys Thr Val Arg Gly Ser Leu
         115                 120                 125            
 Glu Arg Gln Ala Gly Gln Ile Lys Lys Leu Glu Val Asn Glu Ala Glu
     130                 135                 140                
 Leu Leu Arg Arg Arg Asn Phe Lys Val Met Ile Tyr Gln Asp Glu Val
 145                 150                 155                 160
 Lys Leu Pro Ala Lys Leu Ser Ile Ser Lys Ser Leu Lys Glu Ser Glu
                 165                 170                 175    
 Ala Leu Pro Glu Lys Glu Gly Glu Glu Leu Gly Glu Gly Glu Arg Pro
             180                 185                 190        
 Glu Glu Asp Ala Ala Ala Leu Glu Leu Ser Ser Asp Glu Ala Val Glu
         195                 200                 205            
 Val Glu Glu Val Ile Glu Glu Ser Arg Ala Glu Arg Ile Lys Arg Ser
     210                 215                 220                
 Gly Leu Arg Arg Val Asp Asp Phe Lys Lys Ala Phe Ser Lys Glu Lys
 225                 230                 235                 240
 Met Glu Lys Thr Lys Val Arg Thr Arg Glu Asn Leu Glu Lys Thr Arg
                 245                 250                 255    
 Leu Lys Thr Lys Glu Asn Leu Glu Lys Thr Arg His Thr Leu Glu Lys
             260                 265                 270        
 Arg Met Asn Lys Leu Gly Thr Arg Leu Val Pro Ala Glu Arg Arg Glu
         275                 280                 285            
 Lys Leu Lys Thr Ser Arg Asp Lys Leu Arg Lys Ser Phe Thr Pro Asp
     290                 295                 300                
 His Val Val Tyr Ala Arg Ser Lys Thr Ala Val Tyr Lys Val Pro Pro
 305                 310                 315                 320
 Phe Thr Phe His Val Lys Lys Ile Arg Glu Gly Gln Val Glu Val Leu
                 325                 330                 335    
 Lys Ala Thr Glu Met Val Glu Val Gly Ala Asp Asp Asp Glu Gly Gly
             340                 345                 350        
 Ala Glu Arg Gly Glu Ala Gly Asp Leu Arg Arg Gly Ser Ser Pro Asp
         355                 360                 365            
 Val His Ala Leu Leu Glu Ile Thr Glu Glu Ser Asp Ala Val Leu Val
     370                 375                 380                
 Asp Lys Ser Asp Ser Asp
 385                 390



      <210> 896
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 896
 Met Pro Val Ala Ile Asp Val Leu Ile His Leu Pro Gly Gln Glu Val
   1               5                  10                  15    
 Ser His Val Ala Ala Asp Pro Glu Ala Pro Glu Ile Gln Met Phe Pro
              20                  25                  30        
 Gln Ala Gln Glu Ser Pro Ala Ala Val Glu Val Leu Thr Gln Val Val
          35                  40                  45            
 His Pro Ser Ala Ala Met Ala Ser Gln Glu Arg Ala Gln Val Ala Phe
      50                  55                  60                
 Lys Lys Met Val Gln Gly Val Leu Gln Phe Ala Val Cys Asp Thr Ala
  65                  70                  75                  80
 Ala Ala Gly Gln Leu Val Lys Asp Gly Val Thr Gln Val Val Val Ser
                  85                  90                  95    
 Glu Glu Gly Ala Val His Met Val Ala Gly Glu Gly Ala Gln Ile Ile
             100                 105                 110        
 Met Gln Glu Ala Gln Gly Glu His Met Asp Leu Val Glu Ser Asp Gly
         115                 120                 125            
 Glu Ile Ser Gln Ile Ile Val Thr Glu Glu Leu Val Gln Ala Met Val
     130                 135                 140                
 Gln Glu Ser Ser Gly Gly Phe Ser Glu Gly Thr Thr His Tyr Ile Leu
 145                 150                 155                 160
 Thr Glu Leu Pro Pro Gly Val Gln Asp Glu Pro Gly Leu Tyr Ser His
                 165                 170                 175    
 Thr Val Leu Glu Thr Ala Asp Ser Gln Glu Leu Leu Gln Ala Gly Ala
             180                 185                 190        
 Thr Leu Gly Thr Glu Ala Gly Ala Pro Ser Arg Ala Glu Gln Leu Ala
         195                 200                 205            
 Ser Val Val Ile Tyr Thr Gln Glu Gly Ser Ser Ala Ala Ala Ala Ile
     210                 215                 220                
 Gln Ser Gln Arg Glu Ser Ser Glu Leu Gln Glu Ala
 225                 230                 235    



      <210> 897
      <211> 160
      <212> PRT
      <213> Homo sapiens


      <400> 897
 Met Arg Pro Gly Pro Met Leu Gln Ala Arg Val Ser Ile Pro Ala Ala
   1               5                  10                  15    
 Leu Gly Thr Leu Phe Pro Arg Pro Gly Trp Ala Pro Gly Glu Val Ser
              20                  25                  30        
 Ser Glu Ile Ser Ser Arg Asp Leu Leu Asn Pro His Pro Ser Thr Pro
          35                  40                  45            
 Ser Cys Cys Ser Gln Ser Trp Ser Pro Met Ser Val Leu Glu Pro Asp
      50                  55                  60                
 Ser Arg Gly Pro Pro Pro Ile Ser Leu Thr His Thr Gly Ile His Thr
  65                  70                  75                  80
 Pro Gln Lys Thr Ser Gln Met Arg Pro Asp Ser Gly Ser Arg Gly Met
                  85                  90                  95    
 Cys Phe Cys Pro Cys Lys Gly Phe Gly Glu Gly Gly Asn Ile Val Glu
             100                 105                 110        
 Ala Gly Lys Ser Pro Gln Thr Cys Ala His Ala Pro Pro Ala Leu Arg
         115                 120                 125            
 Phe His Ser Ala Phe Ser Glu Cys Pro Cys Cys Thr Gln Thr Thr Gly
     130                 135                 140                
 Gln Glu Arg Pro Ser Leu Pro Leu Gln Pro Leu Ser Leu Pro Phe Asn
 145                 150                 155                 160





      <210> 898
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 898
 Met His Gly Cys Glu Ile Ile Ser Leu Lys Glu Glu Ser Pro Leu Gly
   1               5                  10                  15    
 Lys Val Ser Gln Gly Pro Leu Phe Asn Val Thr Ser Gly Ser Ser Ser
              20                  25                  30        
 Pro Val Thr Trp Leu Gly Leu Leu Ser Phe Gln Asn Leu His Cys Phe
          35                  40                  45            
 Pro Asp Leu Pro Thr Glu Met Pro Leu Arg Ala Lys Gly Val Asn Thr
      50                  55                  60                





      <210> 899
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 899
 Met Val Ser Arg Ser Leu Arg Gly Arg Arg Thr Trp Val Arg Cys Met
   1               5                  10                  15    
 Arg Arg Leu Pro Pro Ile Pro Ala Trp Ser Gln Gly Lys Gly Met Pro
              20                  25                  30        
 Gly Phe Val Ser Leu Leu Val Val His Ala Ala Asp Ala Trp Val Ala
          35                  40                  45            
 Gln Arg Leu Ser Thr Pro Tyr Phe Ser Leu Phe Leu Ser Ile Pro Arg
      50                  55                  60                
 Cys Ser Phe Pro Arg Arg Ser Ile Asp Arg Thr Cys Ser Ser Leu Leu
  65                  70                  75                  80
 Asp Ser Glu Gly Ser Ser Ser Ile Ser Pro Ser Thr Pro Phe Ile Leu
                  85                  90                  95    
 Gln Met Arg Leu Lys Pro Arg Ala Arg
             100                 105



      <210> 900
      <211> 58
      <212> PRT
      <213> Homo sapiens


      <400> 900
 Met Lys Arg Lys Lys Arg Gln Phe Leu Lys Leu Ser Gln Asn Ile Asn
   1               5                  10                  15    
 Arg Trp Lys Asp Val Pro Met Ser Ser Pro Pro Ser Thr Leu Gly Ala
              20                  25                  30        
 Trp Lys Cys Cys Ser Arg Glu Gln Ala Pro Gly Trp Thr Cys Pro Val
          35                  40                  45            
 Leu Thr Thr Ser Val Cys Lys Ser Glu Gln
      50                  55            



      <210> 901
      <211> 263
      <212> PRT
      <213> Homo sapiens


      <400> 901
 Met Ala Ala Pro Ser Gly Thr Val Ser Asp Ser Glu Ser Ser Asn Ser
   1               5                  10                  15    
 Ser Ser Asp Ala Glu Glu Leu Glu Arg Cys Arg Glu Ala Ala Met Pro
              20                  25                  30        
 Ala Trp Gly Leu Glu Gln Arg Pro His Val Ala Gly Lys Pro Arg Ala
          35                  40                  45            
 Gly Ala Ala Asn Ser Gln Leu Ser Thr Ser Gln Pro Ser Leu Arg His
      50                  55                  60                
 Lys Val Asn Glu His Glu Gln Asp Gly Asn Glu Leu Gln Thr Thr Pro
  65                  70                  75                  80
 Glu Phe Arg Ala His Val Ala Lys Lys Leu Gly Ala Leu Leu Asp Ser
                  85                  90                  95    
 Phe Ile Thr Ile Ser Glu Ala Ala Lys Glu Pro Ala Lys Ala Lys Val
             100                 105                 110        
 Gln Lys Val Ala Leu Glu Asp Asp Gly Phe Arg Leu Phe Phe Thr Ser
         115                 120                 125            
 Val Pro Gly Gly Arg Glu Lys Glu Glu Ser Pro Gln Pro Arg Arg Lys
     130                 135                 140                
 Arg Gln Pro Ser Ser Ser Ser Ser Glu Asp Ser Asp Glu Glu Trp Arg
 145                 150                 155                 160
 Arg Cys Arg Glu Ala Ala Val Ser Ala Ser Asp Ile Leu Gln Glu Ser
                 165                 170                 175    
 Ala Ile His Ser Pro Gly Thr Val Glu Lys Glu Ala Lys Lys Lys Arg
             180                 185                 190        
 Lys Leu Lys Lys Lys Ala Lys Lys Val Ala Ser Val Asp Ser Ala Val
         195                 200                 205            
 Ala Ala Thr Thr Pro Thr Ser Met Ala Thr Val Gln Lys Gln Lys Ser
     210                 215                 220                
 Gly Glu Leu Asn Gly Asp Gln Val Ser Leu Gly Thr Lys Lys Lys Lys
 225                 230                 235                 240
 Lys Ala Lys Lys Ala Ser Glu Thr Ser Pro Phe Pro Pro Ala Lys Ser
                 245                 250                 255    
 Ala Thr Ala Ile Pro Ala Asn
             260            



      <210> 902
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 902
 Met Trp Ser Gly Leu Leu Pro Pro Gly Leu Asn Glu Ser Asp Ala Glu
   1               5                  10                  15    
 Ser Asn Ser Glu Asp Glu Ala Thr Leu Glu Asn Ser Gly Leu Asn Leu
              20                  25                  30        
 Gln Glu Asp Lys Glu Asp Glu Ser Ile Arg Lys Thr Glu Ile Ile Asp
          35                  40                  45            
 Phe Ser Thr Asp Glu Pro Lys Thr Glu Thr Glu Ser Asn Val Asn Ala
      50                  55                  60                
 Tyr Glu Glu Cys Pro Ser Gly Ile Pro Ile Asp Met Trp Asn Lys Phe
  65                  70                  75                  80
 Gln Glu Leu His Lys Lys His Ser Glu Gln Lys Ser Thr Thr Ser Arg
                  85                  90                  95    
 Phe Arg Gly Lys Arg Arg Lys Arg Ser Arg Lys Asp Lys Leu Lys Asn
             100                 105                 110        
 Glu Lys Glu Leu His Ser Glu Pro Ser Ser Asn Glu Thr Gln Trp Lys
         115                 120                 125            
 Glu Leu Thr Gln Tyr Phe Gly Val Asn Asp Arg Phe Asp Pro Pro Val
     130                 135                 140                
 Lys Arg Lys Lys Val Glu Lys Ser Gly Leu Glu Lys Arg Ile Asp Gln
 145                 150                 155                 160
 Ala Val Glu Glu Trp Asn Ile Glu Lys Ala Glu Glu Leu Ser Asn Gln
                 165                 170                 175    
 Leu Ala Thr Arg Glu Leu Gly Val Lys Ile Ala Lys Ala Val Ala Cys
             180                 185                 190        
 His Asn Phe Val Lys Ala Lys Lys Glu Val Glu Asn Ser Gln Ala Ala
         195                 200                 205            
 Arg Lys Lys Lys Lys Leu Ala Trp Gly Phe Glu Ala Lys Lys Arg Trp
     210                 215                 220                
 Glu Thr Lys Ser Asn Met Gly Tyr Met
 225                 230            



      <210> 903
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 903
 Met Lys Arg Ser Leu Asn Glu Asn Ser Ala Arg Ser Thr Ala Gly Cys
   1               5                  10                  15    
 Leu Pro Val Pro Leu Phe Asn Gln Lys Lys Arg Asn Arg Gln Pro Leu
              20                  25                  30        
 Thr Ser Asn Pro Leu Lys Asp Asp Ser Gly Ile Ser Thr Pro Ser Asp
          35                  40                  45            
 Asn Tyr Asp Phe Pro Pro Leu Pro Thr Asp Trp Ala Trp Glu Ala Val
      50                  55                  60                
 Asn Pro Glu Leu Ala Pro Val Met Lys Thr Val Asp Thr Gly Gln Ile
  65                  70                  75                  80
 Pro His Ser Val Ser Arg Pro Leu Arg Ser Gln Asp Ser Val Phe Asn
                  85                  90                  95    
 Ser Ile Gln Ser Asn Thr Gly Arg Ser Gln Gly Gly Trp Ser Tyr Arg
             100                 105                 110        
 Asp Gly Asn Lys Asn Thr Ser Leu Lys Thr Trp Asn Lys Asn Thr Leu
         115                 120                 125            
 Pro Cys Val Phe Tyr Glu Ile Asp Arg Glu Leu Pro Arg Leu Ile Arg
     130                 135                 140                
 Gly Arg Val His Arg Cys Val Gly Asn Tyr Asp Gln Lys Lys Asn Ile
 145                 150                 155                 160
 Phe Gln Cys Val Ser Val Arg Pro Ala Ser Val Ser Glu Gln Lys Thr
                 165                 170                 175    
 Phe Gln Ala Phe Val Lys Ile Ala Asp Val Glu Met Gln Tyr Tyr Ile
             180                 185                 190        
 Asn Val Met Asn Glu Thr
         195            



      <210> 904
      <211> 68
      <212> PRT
      <213> Homo sapiens


      <400> 904
 Met Thr Trp His Ser Arg Glu Ser Phe Met Leu Leu Arg Val Val Ala
   1               5                  10                  15    
 Pro Ser Gln Ala Pro Gly Met Gln Val Ser Pro Ser Gln Arg Ala Trp
              20                  25                  30        
 Arg Arg Pro Leu His Arg Cys His Val Ala Ala Pro Arg Pro His His
          35                  40                  45            
 Phe Ala Phe Phe Arg Asn Pro Phe Ser Trp Ser Phe Ile Lys Leu Leu
      50                  55                  60                
 Tyr Arg Tyr Leu
  65            



      <210> 905
      <211> 489
      <212> PRT
      <213> Homo sapiens


      <400> 905
 Met Asn Lys Leu Ser Pro Val Leu Leu Phe Leu Asn Gln Gln Asn Tyr
   1               5                  10                  15    
 Gln Ile Asp Lys Asp Val Glu Asp Lys Arg Gln Lys Ala Ile Glu Glu
              20                  25                  30        
 Phe Phe Thr Lys Asp Val Ile Val Pro Ser Pro Trp Thr Asp His Glu
          35                  40                  45            
 Gly Lys Gln Leu Ser Gln Cys His Ser Ser Lys Cys Thr Asn Ile Asn
      50                  55                  60                
 Ser Asp Ser Pro Val Gly Lys Lys Leu Thr Ile His Ser Glu Lys Ser
  65                  70                  75                  80
 Asp Ala Ala Cys Gln Thr Leu Leu Ser Leu Pro Val Asp Phe Asn Leu
                  85                  90                  95    
 Glu Asn Ile Leu Gly Asp Tyr Phe Arg Ala Asp Glu Phe Ala Asp Gln
             100                 105                 110        
 Ser Pro Gly Asn Leu Ser Ser Ser Ser Leu Arg Arg Lys Leu Phe Leu
         115                 120                 125            
 Asp Gly Asn Gly Ser Ile Ser Asp Ser Leu Pro Ser Ala Ser Pro Gly
     130                 135                 140                
 Ser Pro His Ser Gly Val Gln Thr Ser Leu Glu Met Phe Tyr Ser Ile
 145                 150                 155                 160
 Asp Leu Ser Pro Val Lys Cys Arg Ser Pro Leu Gln Thr Pro Ser Ser
                 165                 170                 175    
 Gly Gln Phe Ser Ser Ser Pro Ile Gln Ala Ser Ala Lys Lys Tyr Ser
             180                 185                 190        
 Leu Gly Ser Ile Thr Ser Pro Ser Pro Ile Ser Ser Pro Thr Phe Ser
         195                 200                 205            
 Pro Ile Glu Phe Gln Ile Gly Glu Thr Pro Leu Ser Glu Gln Arg Lys
     210                 215                 220                
 Phe Thr Val His Ser Pro Asp Ala Ser Ser Gly Thr Asn Ser Asn Gly
 225                 230                 235                 240
 Ile Thr Asn Pro Cys Ile Arg Ser Pro Tyr Ile Asp Gly Cys Ser Pro
                 245                 250                 255    
 Ile Lys Asn Trp Ser Pro Met Arg Leu Gln Met Tyr Ser Gly Gly Thr
             260                 265                 270        
 Gln Tyr Arg Thr Ser Val Ile Gln Ile Pro Phe Thr Leu Glu Thr Gln
         275                 280                 285            
 Gly Glu Asp Glu Glu Asp Lys Glu Asn Ile Pro Ser Thr Asp Val Ser
     290                 295                 300                
 Ser Pro Ala Met Asp Ala Ala Gly Ile His Leu Arg Gln Phe Ser Asn
 305                 310                 315                 320
 Glu Ala Ser Thr His Gly Thr His Leu Val Val Thr Ala Met Ser Val
                 325                 330                 335    
 Thr Gln Asn Gln Ser Ser Ala Ser Glu Lys Glu Leu Ala Leu Leu Gln
             340                 345                 350        
 Asp Val Glu Arg Glu Lys Asp Asn Asn Thr Val Asp Met Val Asp Pro
         355                 360                 365            
 Ile Glu Ile Ala Asp Glu Thr Thr Trp Ile Lys Glu Pro Val Asp Asn
     370                 375                 380                
 Gly Ser Leu Pro Met Thr Asp Phe Val Ser Gly Ile Ala Phe Ser Ile
 385                 390                 395                 400
 Glu Asn Ser His Met Cys Met Ser Pro Leu Ala Glu Ser Ser Val Ile
                 405                 410                 415    
 Pro Cys Glu Ser Ser Asn Ile Gln Met Asp Ser Gly Tyr Asn Thr Gln
             420                 425                 430        
 Asn Cys Gly Ser Asn Ile Met Asp Thr Val Gly Ala Glu Ser Tyr Cys
         435                 440                 445            
 Lys Glu Ser Asp Ala Gln Thr Cys Glu Val Glu Ser Lys Ser Gln Ala
     450                 455                 460                
 Phe Asn Met Lys Gln Asp His Thr Thr Gln Arg Cys Trp Met Lys Thr
 465                 470                 475                 480
 Ala Ser Pro Phe Gln Cys Ser Ser Pro
                 485                



      <210> 906
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 906
 Met Glu Thr His Gln Val Leu Gly Ser Phe Leu Ile Arg Arg Arg Pro
   1               5                  10                  15    
 Cys Pro Thr Ser Ser Met Ser Leu Ser Leu Val Ser Val Ser Val Gly
              20                  25                  30        
 Pro Ser Thr Leu Ala Cys Ser Phe Leu Arg Pro Lys Ala Arg Pro Ser
          35                  40                  45            
 Lys Arg Ser Pro Arg Asn Tyr Thr Asp Ser Thr Ser Pro Gly Gly Pro
      50                  55                  60                
 Arg Ala Pro Arg Gly Gly Ala Trp Arg Leu Ser Ser Gln Gln Asn Ser
  65                  70                  75                  80
 Ser Pro Lys Gly Val Ala Arg Ala Lys Ala Ser Tyr Cys Pro Val Leu
                  85                  90                  95    
 Cys Phe Leu Pro Gly Pro Trp Ser Ser Leu Pro Pro Ala Phe Leu Ile
             100                 105                 110        





      <210> 907
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 907
 Met Ser Ser Gln Lys Gly Asn Val Ala Arg Ser Arg Pro Gln Lys His
   1               5                  10                  15    
 Gln Asn Thr Phe Ser Phe Lys Asn Asp Lys Phe Asp Lys Ser Val Gln
              20                  25                  30        
 Thr Lys Lys Ile Asn Ala Lys Leu His Asp Gly Val Cys Gln Arg Cys
          35                  40                  45            
 Lys Glu Val Leu Glu Trp Arg Val Lys Tyr Ser Lys Tyr Lys Pro Leu
      50                  55                  60                
 Ser Lys Pro Lys Lys Cys Val Lys Cys Leu Gln Lys Thr Val Lys Asp
  65                  70                  75                  80
 Ser Tyr His Ile Met Cys Arg Pro Cys Ala Cys Glu Leu Glu Val Cys
                  85                  90                  95    
 Ala Lys Cys Gly Lys Lys Glu Asp Ile Val Ile Pro Leu Asn Lys Glu
             100                 105                 110        
 Thr Glu Lys Ile Glu His Thr Glu Asn Asn Leu Ser Ser Asn His Arg
         115                 120                 125            
 Arg Ser Cys Arg Arg Asn Glu Glu Ser Asp Asp Asp Leu Asp Phe Asp
     130                 135                 140                
 Ile Asp Leu Glu Asp Thr Gly Gly Asp His Gln Met Asn
 145                 150                 155        



      <210> 908
      <211> 107
      <212> PRT
      <213> Homo sapiens


      <400> 908
 Met Gly Arg Lys Arg Leu Ile Thr Asp Ser Tyr Pro Val Val Lys Arg
   1               5                  10                  15    
 Arg Glu Gly Pro Ala Gly His Ser Lys Gly Glu Leu Ala Pro Glu Leu
              20                  25                  30        
 Gly Glu Glu Pro Gln Pro Arg Asp Glu Glu Glu Ala Glu Leu Glu Leu
          35                  40                  45            
 Leu Arg Gln Phe Asp Leu Ala Trp Gln Tyr Gly Pro Cys Thr Gly Ile
      50                  55                  60                
 Thr Arg Leu Gln Arg Trp Cys Arg Ala Lys Gln Met Gly Leu Glu Pro
  65                  70                  75                  80
 Pro Pro Glu Val Trp Gln Val Leu Lys Thr His Pro Gly Asp Pro Arg
                  85                  90                  95    
 Phe Gln Cys Ser Leu Trp His Leu Tyr Pro Leu
             100                 105        



      <210> 909
      <211> 63
      <212> PRT
      <213> Homo sapiens


      <400> 909
 Met Ala Ser Gln Asn Asn Val Gly Ser Pro Lys Lys Lys Gly Val Arg
   1               5                  10                  15    
 Ile Thr Thr Trp Leu Ile Arg Arg Gly Gln Asp Arg Ala Lys Ala Arg
              20                  25                  30        
 Ile Pro Gly Trp His Pro Val Thr Pro Ser Pro Ile Leu Pro Pro Leu
          35                  40                  45            
 Leu Pro Gln Val Arg Ser Arg Asp Thr Val Val Ser Gln Pro Gln
      50                  55                  60            



      <210> 910
      <211> 95
      <212> PRT
      <213> Homo sapiens


      <400> 910
 Met Asn Gly Cys Ser Pro Leu Leu Leu Phe Pro Pro Thr Ser Leu Met
   1               5                  10                  15    
 Arg Glu Val Val Ala Phe Pro Ser Gln Gly Ala Ser Met Gly Lys Val
              20                  25                  30        
 Ser Lys Ala Ser Gly Gly Ala Glu Tyr Gln Arg Arg Gly Met Ala Val
          35                  40                  45            
 Thr Ile Ser Pro Ser Pro Asn Leu Ser Pro Phe Phe Glu Ser Glu Trp
      50                  55                  60                
 Trp Arg Val Gly Arg Asp Pro Asp Cys Arg Ser Leu Cys Leu Gly Glu
  65                  70                  75                  80
 Gly Lys Asp Val Val Cys Lys Ser Gly Ser Arg Val Gly His Ala
                  85                  90                  95



      <210> 911
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 911
 Met Gly Asn Arg Val Cys Cys Gly Gly Ser Trp Ser Cys Pro Ser Thr
   1               5                  10                  15    
 Phe Gln Lys Lys Lys Lys Arg Gly Ser Gln Thr Arg Arg Thr Leu Lys
              20                  25                  30        
 Pro Gln Pro Gln Gln Leu Gln Gln Asn Leu Pro Lys Gly His Glu Thr
          35                  40                  45            
 Thr Gly His Thr Tyr Glu Arg Val Leu Gln Gln Gln Gly Ser Gln Glu
      50                  55                  60                
 Arg Ser Pro Gly Leu Met Ser Glu Asp Ser Asn Leu His Tyr Ala Asp
  65                  70                  75                  80
 Ile Gln Val Cys Ser Arg Pro His Ala Arg Glu Val Lys His Val His
                  85                  90                  95    
 Leu Glu Asn Ala Thr Glu Tyr Ala Thr Leu Arg Phe Pro Gln Ala Thr
             100                 105                 110        
 Pro Arg Tyr Asp Ser Lys Asn Gly Thr Leu Val
         115                 120            



      <210> 912
      <211> 70
      <212> PRT
      <213> Homo sapiens


      <400> 912
 Met Ala Ser Ala Val Pro Arg Leu Gln Leu Glu Leu Pro Tyr Ser His
   1               5                  10                  15    
 Leu Arg Gln Thr Gln Gln Gly Trp Pro Arg Pro Pro Thr Val Asn Arg
              20                  25                  30        
 Cys Ser Arg Glu Met Asp Gln Pro Leu Phe Cys Leu Phe Tyr Gln Gly
          35                  40                  45            
 Lys Arg Ser Asn His Gly Gln Gly Trp Asn Thr Pro Gly Ser Gly Gln
      50                  55                  60                
 Gly Met Ser Cys Ser Lys
  65                  70



      <210> 913
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 913
 Met Ser Leu Gly Leu Leu Lys Phe Gln Ala Val Gly Glu Glu Asp Glu
   1               5                  10                  15    
 Glu Asp Glu Glu Gly Glu Ser Leu Asp Ser Val Lys Ala Leu Thr Ala
              20                  25                  30        
 Lys Leu Gln Leu Gln Thr Arg Arg Pro Ser Tyr Leu Glu Trp Thr Ala
          35                  40                  45            
 Gln Val Gln Ser Gln Ala Trp Arg Arg Ala Gln Ala Lys Pro Gly Pro
      50                  55                  60                
 Gly Gly Pro Gly Asp Ile Cys Gly Phe Asp Ser Met Asp Ser Ala Leu
  65                  70                  75                  80
 Glu Trp Leu Arg Arg Glu Leu Arg Glu Met Gln Ala Gln Asp Arg Gln
                  85                  90                  95    
 Leu Ala Gly Gln Leu Leu Arg Leu Arg Ala Gln Leu His Arg Leu Lys
             100                 105                 110        
 Met Asp Gln Ala Cys His Leu His Gln Glu Leu Leu Asp Glu Ala Glu
         115                 120                 125            
 Leu Glu Leu Glu Leu Glu Pro Gly Ala Gly Leu Ala Leu Ala Pro Leu
     130                 135                 140                
 Leu Arg His Leu Gly Leu Thr Arg Met Asn Ile Ser Ala Arg Arg Phe
 145                 150                 155                 160
 Thr Leu Cys
            



      <210> 914
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 914
 Met Pro Arg Gly Ser Arg Ser Ala Ala Ser Arg Pro Ala Ser Arg Pro
   1               5                  10                  15    
 Ala Ala Pro Ser Ala His Pro Pro Ala His Pro Pro Pro Ser Ala Ala
              20                  25                  30        
 Ala Pro Ala Pro Ala Pro Ser Gly Gln Pro Gly Leu Met Ala Gln Met
          35                  40                  45            
 Ala Thr Thr Ala Ala Gly Val Ala Val Gly Ser Ala Val Gly His Val
      50                  55                  60                
 Met Gly Ser Ala Leu Thr Gly Ala Phe Ser Gly Gly Ser Ser Glu Pro
  65                  70                  75                  80
 Ser Gln Pro Ala Val Gln Gln Ala Pro Thr Pro Ala Ala Pro Gln Pro
                  85                  90                  95    
 Leu Gln Met Gly Pro Cys Ala Tyr Glu Ile Arg Gln Phe Leu Asp Cys
             100                 105                 110        
 Ser Thr Thr Gln Ser Asp Leu Ser Leu Cys Glu Gly Phe Ser Glu Ala
         115                 120                 125            
 Leu Lys Gln Cys Lys Tyr Tyr His Gly Leu Ser Ser Leu Pro
     130                 135                 140        



      <210> 915
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 915
 Met Glu Glu Asp Gln Glu Leu Glu Arg Lys Ala Ile Glu Glu Leu Leu
   1               5                  10                  15    
 Lys Glu Ala Lys Arg Gly Lys Thr Arg Ala Glu Thr Met Gly Pro Met
              20                  25                  30        
 Gly Trp Met Lys Cys Pro Leu Ala Ser Thr Asn Lys Arg Phe Leu Ile
          35                  40                  45            
 Asn Thr Ile Lys Asn Thr Leu Pro Ser His Lys Glu Gln Asp His Glu
      50                  55                  60                
 Gln Lys Glu Gly Asp Lys Glu Pro Ala Lys Ser Gln Ala Gln Lys Glu
  65                  70                  75                  80
 Glu Asn Pro Lys Lys His Arg Ser His Pro Tyr Lys His Ser Phe Arg
                  85                  90                  95    
 Ala Arg Gly Ser Ala Ser Tyr Ser Pro Pro Arg Lys Arg Ser Ser Gln
             100                 105                 110        
 Asp Lys Tyr Glu Lys Arg Ser Asn Arg Arg
         115                 120        



      <210> 916
      <211> 780
      <212> PRT
      <213> Homo sapiens


      <400> 916
 Met Glu Arg Met Asn Trp Leu Ser Arg Leu Ala Ser Arg Gly Pro Gly
   1               5                  10                  15    
 His Arg Ile Pro Gln Gly Ala Asn Leu Gln Thr Pro Val Met Ala Asp
              20                  25                  30        
 Pro Glu Thr Cys Leu Met Val Phe Lys Asn His Trp Ser Gln Val Val
          35                  40                  45            
 Arg Ile Leu Glu Arg Gln Gly Pro Arg Ala Ala Pro Gly Gly Ala Asp
      50                  55                  60                
 Asp Leu Ser Ala Val Arg Asn His Thr Tyr Gln Met Leu Thr Leu Leu
  65                  70                  75                  80
 Ala Glu Asp Arg Ala Val Pro Ser Ala Pro Thr Gly Pro Gly Pro Leu
                  85                  90                  95    
 Leu Glu Phe Ala Leu His Glu Asp Leu Leu Thr Arg Val Leu Thr Trp
             100                 105                 110        
 Gln Leu Gln Trp Asp Glu Leu Gly Asp Gly Val Glu Glu Arg Arg Ala
         115                 120                 125            
 Glu Gln Leu Lys Leu Phe Glu Met Leu Val Ser Glu Ala Arg Gln Pro
     130                 135                 140                
 Leu Leu Arg His Gly Pro Val Arg Glu Ala Leu Leu Thr Leu Leu Asp
 145                 150                 155                 160
 Ala Cys Gly Arg Pro Val Pro Ser Ser Pro Ala Leu Asp Glu Gly Leu
                 165                 170                 175    
 Val Leu Leu Leu Ser Gln Leu Cys Val Cys Val Ala Gln Glu Pro Ser
             180                 185                 190        
 Leu Leu Glu Phe Phe Leu Gln Pro Pro Pro Glu Pro Gly Ala Ala Pro
         195                 200                 205            
 Arg Leu Leu Leu Phe Ser Arg Leu Val Pro Phe Val His Arg Glu Gly
     210                 215                 220                
 Thr Leu Gly Gln Gln Ala Arg Asp Ala Leu Leu Leu Leu Met Ala Leu
 225                 230                 235                 240
 Ser Ala Gly Ser Pro Thr Val Gly Arg Tyr Ile Ala Asp His Ser Tyr
                 245                 250                 255    
 Phe Cys Pro Val Leu Ala Thr Gly Leu Ser Ala Leu Tyr Ser Ser Leu
             260                 265                 270        
 Pro Arg Lys Ile Glu Val Pro Gly Asp Asp Trp His Cys Leu Arg Arg
         275                 280                 285            
 Glu Asp Trp Leu Gly Val Pro Ala Leu Ala Leu Phe Met Ser Ser Leu
     290                 295                 300                
 Glu Phe Cys Asn Ala Val Ile Gln Val Ala His Pro Leu Val Gln Lys
 305                 310                 315                 320
 Gln Leu Val Asp Tyr Ile His Asn Gly Phe Leu Val Pro Val Met Gly
                 325                 330                 335    
 Pro Ala Leu His Lys Thr Ser Val Glu Glu Met Ile Ala Ser Thr Ala
             340                 345                 350        
 Tyr Leu Glu Leu Phe Leu Arg Ser Ile Ser Glu Pro Ala Leu Leu Arg
         355                 360                 365            
 Thr Phe Leu Arg Phe Leu Leu Leu His Arg His Asp Thr His Thr Ile
     370                 375                 380                
 Leu Asp Thr Leu Val Ala Arg Ile Gly Ser Asn Ser Arg Leu Cys Met
 385                 390                 395                 400
 Val Ser Leu Ser Leu Phe Arg Thr Leu Leu Asn Leu Ser Cys Glu Asp
                 405                 410                 415    
 Val Leu Leu Gln Leu Val Leu Arg Tyr Leu Val Pro Cys Asn His Val
             420                 425                 430        
 Met Leu Ser Gln Lys Pro Ala Val Arg Asp Val Asp Leu Tyr Gly Arg
         435                 440                 445            
 Ala Ala Asp Lys Phe Leu Ser Leu Ile Pro Arg Cys Cys Arg His His
     450                 455                 460                
 Ala Pro Ser Pro Pro Arg Pro Glu His Ala Ser Trp Ala Arg Gly Pro
 465                 470                 475                 480
 Gly Ser Pro Ser Val Asp Ser Ser Ser Val Thr Thr Val Pro Arg Pro
                 485                 490                 495    
 Ser Thr Pro Ser Arg Leu Ala Leu Phe Leu Arg Gln Gln Ser Leu Gly
             500                 505                 510        
 Gly Ser Glu Ser Pro Gly Pro Ala Pro Cys Ser Pro Gly Leu Ser Ala
         515                 520                 525            
 Ser Pro Ala Ser Ser Pro Gly Arg Arg Pro Thr Pro Ala Glu Glu Pro
     530                 535                 540                
 Gly Glu Leu Glu Asp Asn Tyr Leu Glu Tyr Leu Arg Glu Ala Arg Arg
 545                 550                 555                 560
 Gly Val Asp Arg Cys Val Arg Ala Cys Arg Thr Trp Ser Ala Pro Tyr
                 565                 570                 575    
 Asp Gly Glu Arg Pro Ser Pro Glu Pro Ser Pro Phe Gly Ser Arg Thr
             580                 585                 590        
 Lys Lys Arg Ser Leu Leu Pro Glu Glu Asp Arg Asn Asn Val Gly Glu
         595                 600                 605            
 Gly Glu Glu Glu Glu Leu Gly Arg Arg Gly Arg Ala Gly Gly Ala Gly
     610                 615                 620                
 Glu Gly Pro Gly His Leu Pro Pro Pro Gln Leu Asn Gly Val Pro Gly
 625                 630                 635                 640
 Ser Trp Pro Glu Gly Ala Lys Lys Val Arg Leu Val Pro Lys Glu Gly
                 645                 650                 655    
 Ala Gly Glu Leu Leu Glu Gly Ile Ser Glu Gly Met Ala Gly Leu Glu
             660                 665                 670        
 Gly Phe Gly Gln Glu Leu Arg Glu Leu Glu Val Ala Leu Ser Asn Gly
         675                 680                 685            
 Gly Thr Gly Ser Glu Ser Pro Leu Glu Pro Pro Leu Pro Leu Glu Glu
     690                 695                 700                
 Glu Glu Ala Tyr Glu Ser Phe Thr Cys Pro Pro Glu Pro Pro Gly Pro
 705                 710                 715                 720
 Phe Leu Ser Ser Pro Leu Arg Thr Leu Asn Gln Leu Pro Ser Gln Pro
                 725                 730                 735    
 Phe Thr Gly Pro Phe Met Ala Val Leu Phe Ala Lys Leu Glu Asn Met
             740                 745                 750        
 Leu Gln Asn Ser Ala Leu Ser Cys Ser Thr Pro Thr Trp Ser Ser Ser
         755                 760                 765            
 Pro Val Ser Ser Pro Cys Cys Arg Cys Trp Ala Leu
     770                 775                 780



      <210> 917
      <211> 794
      <212> PRT
      <213> Homo sapiens


      <400> 917
 Met Glu Arg Met Asn Trp Leu Ser Arg Leu Ala Ser Arg Gly Pro Gly
   1               5                  10                  15    
 His Arg Ile Pro Gln Gly Ala Asn Leu Gln Thr Pro Val Met Ala Asp
              20                  25                  30        
 Pro Glu Thr Cys Leu Met Val Phe Lys Asn His Trp Ser Gln Val Val
          35                  40                  45            
 Arg Ile Leu Glu Arg Gln Gly Pro Arg Ala Ala Pro Gly Gly Ala Asp
      50                  55                  60                
 Asp Leu Ser Ala Val Arg Asn His Thr Tyr Gln Met Leu Thr Leu Leu
  65                  70                  75                  80
 Ala Glu Asp Arg Ala Val Pro Ser Ala Pro Thr Gly Pro Gly Pro Leu
                  85                  90                  95    
 Leu Glu Phe Ala Leu His Glu Asp Leu Leu Thr Arg Val Leu Thr Trp
             100                 105                 110        
 Gln Leu Gln Trp Asp Glu Leu Gly Asp Gly Val Glu Glu Arg Arg Ala
         115                 120                 125            
 Glu Gln Leu Lys Leu Phe Glu Met Leu Val Ser Glu Ala Arg Gln Pro
     130                 135                 140                
 Leu Leu Arg His Gly Pro Val Arg Glu Ala Leu Leu Thr Leu Leu Asp
 145                 150                 155                 160
 Ala Cys Gly Arg Pro Val Pro Ser Ser Pro Ala Leu Asp Glu Gly Leu
                 165                 170                 175    
 Val Leu Leu Leu Ser Gln Leu Cys Val Cys Val Ala Gln Glu Pro Ser
             180                 185                 190        
 Leu Leu Glu Phe Phe Leu Gln Pro Pro Pro Glu Pro Gly Ala Ala Pro
         195                 200                 205            
 Arg Leu Leu Leu Phe Ser Arg Leu Val Pro Phe Val His Arg Glu Gly
     210                 215                 220                
 Thr Leu Gly Gln Gln Ala Arg Asp Ala Leu Leu Leu Leu Met Ala Leu
 225                 230                 235                 240
 Ser Ala Gly Ser Pro Thr Val Gly Arg Tyr Ile Ala Asp His Ser Tyr
                 245                 250                 255    
 Phe Cys Pro Val Leu Ala Thr Gly Leu Ser Ala Leu Tyr Ser Ser Leu
             260                 265                 270        
 Pro Arg Lys Ile Glu Val Pro Gly Asp Asp Trp His Cys Leu Arg Arg
         275                 280                 285            
 Glu Asp Trp Leu Gly Val Pro Ala Leu Ala Leu Phe Met Ser Ser Leu
     290                 295                 300                
 Glu Phe Cys Asn Ala Val Ile Gln Val Ala His Pro Leu Val Gln Lys
 305                 310                 315                 320
 Gln Leu Val Asp Tyr Ile His Asn Gly Phe Leu Val Pro Val Met Gly
                 325                 330                 335    
 Pro Ala Leu His Lys Thr Ser Val Glu Glu Met Ile Ala Ser Thr Ala
             340                 345                 350        
 Tyr Leu Glu Leu Phe Leu Arg Ser Ile Ser Glu Pro Ala Leu Leu Arg
         355                 360                 365            
 Thr Phe Leu Arg Phe Leu Leu Leu His Arg His Asp Thr His Thr Ile
     370                 375                 380                
 Leu Asp Thr Leu Val Ala Arg Ile Gly Ser Asn Ser Arg Leu Cys Met
 385                 390                 395                 400
 Val Ser Leu Ser Leu Phe Arg Thr Leu Leu Asn Leu Ser Cys Glu Asp
                 405                 410                 415    
 Val Leu Leu Gln Leu Val Leu Arg Tyr Leu Val Pro Cys Asn His Val
             420                 425                 430        
 Met Leu Ser Gln Lys Pro Ala Val Arg Asp Val Asp Leu Tyr Gly Arg
         435                 440                 445            
 Ala Ala Asp Lys Phe Leu Ser Leu Ile Pro Arg Cys Cys Arg His His
     450                 455                 460                
 Ala Pro Ser Pro Pro Arg Pro Glu His Ala Ser Trp Ala Arg Gly Gly
 465                 470                 475                 480
 Pro Ser Arg Glu Thr Gly Arg Arg Glu Asp Ile Thr Gly Pro Gly Ser
                 485                 490                 495    
 Pro Ser Val Asp Ser Ser Ser Val Thr Thr Val Pro Arg Pro Ser Thr
             500                 505                 510        
 Pro Ser Arg Leu Ala Leu Phe Leu Arg Gln Gln Ser Leu Gly Gly Ser
         515                 520                 525            
 Glu Ser Pro Gly Pro Ala Pro Cys Ser Pro Gly Leu Ser Ala Ser Pro
     530                 535                 540                
 Ala Ser Ser Pro Gly Arg Arg Pro Thr Pro Ala Glu Glu Pro Gly Glu
 545                 550                 555                 560
 Leu Glu Asp Asn Tyr Leu Glu Tyr Leu Arg Glu Ala Arg Arg Gly Val
                 565                 570                 575    
 Asp Arg Cys Val Arg Ala Cys Arg Thr Trp Ser Ala Pro Tyr Asp Gly
             580                 585                 590        
 Glu Arg Pro Ser Pro Glu Pro Ser Pro Phe Gly Ser Arg Thr Lys Lys
         595                 600                 605            
 Arg Ser Leu Leu Pro Glu Glu Asp Arg Asn Asn Val Gly Glu Gly Glu
     610                 615                 620                
 Glu Glu Glu Leu Gly Arg Arg Gly Arg Ala Gly Gly Ala Gly Glu Gly
 625                 630                 635                 640
 Pro Gly His Leu Pro Pro Pro Gln Leu Asn Gly Val Pro Gly Ser Trp
                 645                 650                 655    
 Pro Glu Gly Ala Lys Lys Val Arg Leu Val Pro Lys Glu Gly Ala Gly
             660                 665                 670        
 Glu Leu Leu Glu Gly Ile Ser Glu Gly Met Ala Gly Leu Glu Gly Phe
         675                 680                 685            
 Gly Gln Glu Leu Arg Glu Leu Glu Val Ala Leu Ser Asn Gly Gly Thr
     690                 695                 700                
 Gly Ser Glu Ser Pro Leu Glu Pro Pro Leu Pro Leu Glu Glu Glu Glu
 705                 710                 715                 720
 Ala Tyr Glu Ser Phe Thr Cys Pro Pro Glu Pro Pro Gly Pro Phe Leu
                 725                 730                 735    
 Ser Ser Pro Leu Arg Thr Leu Asn Gln Leu Pro Ser Gln Pro Phe Thr
             740                 745                 750        
 Gly Pro Phe Met Ala Val Leu Phe Ala Lys Leu Glu Asn Met Leu Gln
         755                 760                 765            
 Asn Ser Ala Leu Ser Cys Ser Thr Pro Thr Trp Ser Ser Ser Pro Val
     770                 775                 780                
 Ser Ser Pro Cys Cys Arg Cys Trp Ala Leu
 785                 790                



      <210> 918
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 918
 Met Tyr Leu Gly Ile Thr Pro Ser Val Thr Cys Asn Asn Ser Ser Lys
   1               5                  10                  15    
 Asn Glu Phe Ser Leu Ile Leu Glu Lys Asn Pro Leu Val Glu Phe Val
              20                  25                  30        
 Glu Glu Leu Pro Ala Gly Arg Ser Ser Leu Cys Tyr Cys Asn Leu Leu
          35                  40                  45            
 Cys Gly Ile Ile Arg Gly Ala Leu Glu Met Val His Leu Ala Ala Asp
      50                  55                  60                
 Val Thr Phe Leu Gln Asp Arg Leu Lys Gly Asp Ser Val Thr Glu Ile
  65                  70                  75                  80
 Gly Ile Thr Phe Leu Lys Lys Arg Asp Glu Lys Lys Tyr Arg Gly Lys
                  85                  90                  95    
 Lys
    



      <210> 919
      <211> 190
      <212> PRT
      <213> Homo sapiens


      <400> 919
 Met Ser Val Ser Gly Lys Lys Glu Phe Asp Val Lys Gln Ile Leu Arg
   1               5                  10                  15    
 Leu Arg Trp Arg Trp Phe Ser His Pro Phe Gln Gly Ser Thr Asn Thr
              20                  25                  30        
 Gly Ser Cys Leu Gln Gln Glu Gly Tyr Glu His Arg Gly Thr Pro Val
          35                  40                  45            
 Gln Gly Arg Leu Lys Ser His Ser Arg Asp Arg Asn Gly Leu Lys Lys
      50                  55                  60                
 Ser Asn Ser Pro Val His His Asn Ile Leu Ala Pro Val Pro Gly Pro
  65                  70                  75                  80
 Ala Pro Ala His Gln Arg Ala Val Gln Asn Leu Gln Gln His Asn Leu
                  85                  90                  95    
 Ile Val His Phe Gln Ala Asn Glu Asp Thr Pro Lys Ser Val Pro Glu
             100                 105                 110        
 Lys Asn Leu Phe Lys Glu Ala Cys Glu Lys Arg Ala Gln Asp Leu Glu
         115                 120                 125            
 Met Met Ala Asp Asp Asn Ile Glu Asp Ser Thr Ala Arg Lys Lys Val
     130                 135                 140                
 Met Lys Gln Arg Ser Leu Met Tyr Thr Pro Met Glu Asp Phe Ser Phe
 145                 150                 155                 160
 Val Glu Met Lys Asp Ile Tyr Trp Arg Arg Leu Gln Asn Glu Glu Thr
                 165                 170                 175    
 Lys Lys Glu Gly Ser Gln Lys Val Pro Phe Tyr Lys Lys Ile
             180                 185                 190



      <210> 920
      <211> 165
      <212> PRT
      <213> Homo sapiens


      <400> 920
 Met Asp Ser Ser Arg Ala Arg Gln Gln Leu Arg Arg Arg Phe Leu Leu
   1               5                  10                  15    
 Leu Pro Asp Ala Glu Ala Gln Leu Asp Arg Glu Gly Asp Ala Gly Pro
              20                  25                  30        
 Glu Thr Ser Thr Ala Val Glu Lys Lys Glu Lys Pro Leu Pro Arg Leu
          35                  40                  45            
 Asn Ile His Ser Gly Phe Trp Ile Leu Ala Ser Ile Val Val Thr Tyr
      50                  55                  60                
 Tyr Val Asp Phe Phe Lys Thr Leu Lys Glu Asn Phe His Thr Ser Ser
  65                  70                  75                  80
 Trp Phe Leu Cys Gly Ser Ala Leu Leu Leu Val Ser Leu Ser Ile Ala
                  85                  90                  95    
 Phe Tyr Cys Ile Val Tyr Leu Glu Trp Tyr Cys Gly Ile Gly Glu Tyr
             100                 105                 110        
 Asp Val Lys Tyr Pro Ala Leu Ile Pro Ile Thr Thr Ala Ser Phe Ile
         115                 120                 125            
 Ala Ala Gly Ile Cys Phe Asn Ile Ala Leu Trp His Val Trp Ser Phe
     130                 135                 140                
 Phe Thr Pro Leu Leu Leu Phe Thr Gln Phe Met Gly Val Val Met Phe
 145                 150                 155                 160
 Ile Thr Leu Leu Gly
                 165



      <210> 921
      <211> 22
      <212> PRT
      <213> Homo sapiens


      <400> 921
 Met Leu Pro Phe Pro Ser Pro Pro Ala Pro Pro Ser His Pro Ala Pro
   1               5                  10                  15    
 Pro Ala Tyr Thr Leu Ala
              20        



      <210> 922
      <211> 301
      <212> PRT
      <213> Homo sapiens


      <400> 922
 Met Leu Ser Glu Gly Tyr Leu Ser Gly Leu Glu Tyr Trp Asn Asp Ile
   1               5                  10                  15    
 His Trp Ser Cys Ala Ser Tyr Asn Glu Gln Val Ala Gly Glu Lys Glu
              20                  25                  30        
 Glu Glu Thr Asn Ser Val Ala Thr Leu Ser Tyr Ser Ser Val Asp Glu
          35                  40                  45            
 Thr Gln Val Arg Ser Leu Tyr Val Ser Cys Lys Ser Ser Gly Lys Phe
      50                  55                  60                
 Ile Ser Ser Val His Ser Arg Glu Ser Gln His Ser Arg Ser Gln Arg
  65                  70                  75                  80
 Val Thr Val Leu Gln Thr Asn Pro Asn Pro Val Phe Glu Ser Pro Asn
                  85                  90                  95    
 Leu Ala Ala Val Glu Ile Cys Arg Asp Ala Ser Arg Glu Thr Tyr Leu
             100                 105                 110        
 Val Pro Ser Ser Cys Lys Ser Ile Cys Lys Asn Tyr Asn Asp Leu Gln
         115                 120                 125            
 Ile Ala Gly Gly Gln Val Met Ala Ile Asn Ser Val Thr Thr Asp Phe
     130                 135                 140                
 Pro Ser Glu Ser Ser Phe Glu Tyr Gly Pro Leu Leu Lys Ser Ser Glu
 145                 150                 155                 160
 Ile Pro Leu Pro Met Glu Asp Ser Ile Ser Thr Gln Pro Ser Asp Phe
                 165                 170                 175    
 Pro Gln Lys Pro Ile Gln Arg Tyr Ser Ser Tyr Trp Arg Ile Thr Ser
             180                 185                 190        
 Ile Lys Glu Lys Ser Ser Leu Gln Met Gln Asn Pro Ile Ser Asn Ala
         195                 200                 205            
 Val Leu Asn Glu Tyr Leu Glu Gln Lys Val Val Glu Leu Tyr Lys Gln
     210                 215                 220                
 Tyr Ile Met Asp Thr Val Phe His Asp Ser Ser Pro Thr Gln Ile Leu
 225                 230                 235                 240
 Ala Ser Glu Leu Ile Met Thr Ser Val Asp Gln Ile Ser Leu Gln Val
                 245                 250                 255    
 Ser Arg Glu Lys Asn Leu Glu Thr Ser Lys Ala Arg Asp Ile Val Phe
             260                 265                 270        
 Ser Arg Leu Leu Gln Leu Met Ser Thr Glu Ile Thr Glu Ile Ser Thr
         275                 280                 285            
 Pro Ser Leu His Ile Ser Gln Tyr Ser Asn Val Asn Pro
     290                 295                 300    



      <210> 923
      <211> 228
      <212> PRT
      <213> Homo sapiens


      <400> 923
 Met Ser Pro Ser Ile Ser Asp Pro Cys Leu Gly Gln Ala Leu Met Gly
   1               5                  10                  15    
 Gly Pro Ser Phe Lys Ala Val Val Gly Thr Ala Pro Pro Asn Ala Ser
              20                  25                  30        
 Leu Ser Phe Leu Pro Ile His Gln Tyr Thr Ala Gly Pro Phe Leu Val
          35                  40                  45            
 Phe Val Gln Gln Glu Thr His Phe Trp Trp Asp Met Pro Ser Ser Ala
      50                  55                  60                
 Thr Gly Pro Leu Thr Pro Cys Ile Ser Val Leu Pro Val Ser Ala Gly
  65                  70                  75                  80
 Thr Asp Ser Lys Gly Lys Pro Ser Val Trp Arg Ile Gly Gly Trp Glu
                  85                  90                  95    
 Gln Arg Gly Glu Asn Ala Val Leu Ser Phe Cys Leu Gly Ile Pro His
             100                 105                 110        
 Thr Thr Trp Val Leu Pro Gly Lys Pro Val Leu Ser Lys Thr Met Asp
         115                 120                 125            
 Leu Ala Ser Pro Thr Gly Leu Gln Ser Gln His Leu Arg Glu Gly Gly
     130                 135                 140                
 Trp Lys Arg Leu Cys Pro His Phe Glu Leu Gln Ala Gly Ser Ala Ala
 145                 150                 155                 160
 Leu Lys Pro Ser Ser Asp Phe Leu Thr Gln Asp Pro Ala Pro Gly Arg
                 165                 170                 175    
 Arg Arg Val Gly Ala Gly Leu Val Gly Gln Lys Glu Ala Ser Ala Gly
             180                 185                 190        
 Leu Glu Asp Pro Ser Ser Thr Ser His Ser Val Ser Ser Ser Trp Glu
         195                 200                 205            
 Asn Leu Cys Gln Ala Arg Ala Val Ile Gly Pro His Glu Val Ser Glu
     210                 215                 220                
 Ala Pro Ser Trp
 225            



      <210> 924
      <211> 165
      <212> PRT
      <213> Homo sapiens


      <400> 924
 Met Tyr Ser Phe Pro Pro Ala Thr Ser Cys Pro Leu His Ile His Glu
   1               5                  10                  15    
 Ser Leu Pro Ala Arg Glu Gly His Pro Ser Phe Leu Gln His Gly Arg
              20                  25                  30        
 Tyr Leu Trp Asp Arg Asp Phe Pro Trp Arg Ala Ala Glu Ser Gly Gln
          35                  40                  45            
 Ser Gln Lys Gln Val Ser Lys Gly Pro Arg Glu Arg Gly Leu Cys Pro
      50                  55                  60                
 Gly Gly Ser Leu His Arg Asp Gln Cys Leu Leu His Ser Cys Ser Ser
  65                  70                  75                  80
 Gly Leu Thr Pro Pro Arg Pro Leu Pro Ser Arg Ser Asp Pro Pro Pro
                  85                  90                  95    
 Gly His Leu Leu Arg Gly Val Leu Cys Thr Leu Leu Phe Gly Leu Leu
             100                 105                 110        
 Leu Thr Cys Ala Leu Val Leu Trp Gly Glu Gly Ile Ala Val Gly Lys
         115                 120                 125            
 Ala Glu Gln Leu Gln Pro Ser Leu Pro Leu Leu His Val Ala Gly Ala
     130                 135                 140                
 Gln Ala Arg Arg Ala Gly Ala Ser Val Arg Leu Arg Pro Pro Gly Ala
 145                 150                 155                 160
 Tyr Gln Gly Pro Glu
                 165



      <210> 925
      <211> 143
      <212> PRT
      <213> Homo sapiens


      <400> 925
 Met Pro Pro Lys Pro Arg Gly Leu Pro Arg Cys Pro Pro Cys Gln Ser
   1               5                  10                  15    
 Val Trp Pro Leu Pro Gly Pro Gly Trp Leu Gln Gly Val Gly Leu Pro
              20                  25                  30        
 Phe Pro Leu Pro Phe Pro Gly Leu Ser Gln Ala Gln Ser Pro Cys Phe
          35                  40                  45            
 Ser Phe Pro Val Trp Gly Asp Arg Arg Val Ala Thr Glu Pro Gly Ser
      50                  55                  60                
 Ala Leu Gly Ala Ala Gly Leu Gln Thr Trp Leu Trp Ser Cys Ser Pro
  65                  70                  75                  80
 Gly Glu Gly Gly Gly Pro Gly Glu Asp Glu Leu Pro Asn Thr Cys Tyr
                  85                  90                  95    
 Gly Ser Phe Gln Ser Gln Ala Ala Arg Thr Gln Ser Gln Arg Ser Ile
             100                 105                 110        
 Arg Trp Gly Trp Gly His Val Gly Trp Pro Trp Leu Ser Gln Val Gly
         115                 120                 125            
 Ser Cys Gln Ala Lys Ser Tyr Ala Lys Trp Gly Pro Pro Trp Pro
     130                 135                 140            



      <210> 926
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 926
 Met Ala Ala Glu Gly Ser Arg Phe Ser Ser Gln Ser Pro Gly Leu Val
   1               5                  10                  15    
 Asp Arg Gln Gly Pro Lys Cys Asp Pro Ser Arg Leu Val Ser Pro Trp
              20                  25                  30        
 Gly Arg His Gly Leu Arg Ile Leu Gln Ile Gly His His His Gly Arg
          35                  40                  45            
 Asp Gly Gln His Glu Ala Thr His His Leu Leu Arg Val Leu Arg Ala
      50                  55                  60                
 Pro Arg Val Gly Lys Ala Asp Glu Gly Ala Val Asp Ser Asp Pro Ser
  65                  70                  75                  80
 Thr Pro Leu Gln Leu Lys His Glu Ala Ala His Ala Glu Asp His Ala
                  85                  90                  95    
 Gln Gln Val His Val Val Arg Arg Arg Val Val Gln Gly Arg Val Thr
             100                 105                 110        
 Phe Ala Arg Arg Gly Leu Val Pro Gln His Phe Val Arg Pro Pro Trp
         115                 120                 125            
 Val Arg His Ile Val Ser Gly His Ser Glu Ser Lys Ala Arg Ser Arg
     130                 135                 140                
 Leu Phe Arg Cys Arg Asn Arg Ser Phe Arg Arg Ala Ser
 145                 150                 155        



      <210> 927
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 927
 Met Met Ser Pro Gly Leu Leu Leu Lys Pro Trp Trp Gly Gly Ala Gln
   1               5                  10                  15    
 Ser Glu Met Gly Arg Asn Gly Met Leu Glu Gly Cys Ser Val Met Ser
              20                  25                  30        
 Val Gly Ala Ser Arg Leu Gly Glu Gly Arg Val Arg Pro Arg Ala His
          35                  40                  45            
 Ser Arg Arg Pro Val Thr Arg Pro Arg Trp Arg Ala Ala Gly Pro Cys
      50                  55                  60                
 Thr Gly Thr Cys Gln Gly Gly Ser His Ser Arg Thr Leu Val Leu Arg
  65                  70                  75                  80
 Leu Lys Ala Val Ser Thr Thr Pro Thr Ser Ala Asn Asp Leu Val Gln
                  85                  90                  95    
 Ile Lys Phe Arg Arg Asp Gly Gly Asn Arg Val Val Glu Ala Leu Asn
             100                 105                 110        
 Leu Ser Glu Lys Arg Lys Asp Arg Lys Ala Leu Cys Phe Ser Gln Ser
         115                 120                 125            
 Leu His Leu Gln Gly Glu Glu Ile Glu Leu Thr Ala Leu Ser Arg Ser
     130                 135                 140                
 Phe Gln Leu Arg Asn Val Tyr Phe Met Ile Ser Asn Ile
 145                 150                 155        



      <210> 928
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 928
 Met Gly Leu Gln Pro Gly Asn Ile Ser Pro Thr Ser Lys Leu Val Ser
   1               5                  10                  15    
 Arg Ser Thr Leu Arg Arg Gln Gly Lys Glu Ser Ser Ile Glu Gly Asn
              20                  25                  30        
 Gly Ile Gly Val Asn Ser Ser Asn Arg Leu Gly Ile Asp Asn Phe Glu
          35                  40                  45            
 Phe Ile Arg Val Leu Gly Lys Gly Ser Leu Gly Met Asp Leu Ile Pro
      50                  55                  60                
 Arg Leu Ser Gln Ala Pro Leu Leu Leu Thr Asp Pro Val Phe Thr Glu
  65                  70                  75                  80
 Thr Ile Ile Met Phe Asp
                  85    



      <210> 929
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 929
 Met Phe Leu Cys Lys Glu Val Lys Trp Ser Asn Leu Trp Ala Val Lys
   1               5                  10                  15    
 Ile Asn Leu Leu Thr Ile Ala Tyr Thr Ile Lys Leu Asp Trp Gly Ile
              20                  25                  30        
 Tyr Tyr Tyr Ile Ser Met Lys Tyr Lys Leu Asn Arg Ser Arg Val Arg
          35                  40                  45            
 Asn Ser Ala Arg Arg Arg Lys Thr
      50                  55    



      <210> 930
      <211> 148
      <212> PRT
      <213> Homo sapiens


      <400> 930
 Met Pro Val Leu Lys Gln Leu Gly Pro Ala Gln Pro Lys Lys Arg Pro
   1               5                  10                  15    
 Asp Arg Gly Ala Leu Ser Ile Ser Ala Pro Leu Gly Asp Phe Arg His
              20                  25                  30        
 Thr Leu His Val Gly Arg Gly Gly Asp Ala Phe Gly Asp Thr Ser Phe
          35                  40                  45            
 Leu Ser Arg His Gly Gly Gly Pro Pro Pro Glu Pro Arg Ala Pro Pro
      50                  55                  60                
 Ala Gly Ala Pro Arg Ser Pro Pro Pro Pro Ala Val Pro Gln Ser Ala
  65                  70                  75                  80
 Ala Pro Ser Pro Ala Asp Pro Leu Leu Ser Phe His Leu Asp Leu Gly
                  85                  90                  95    
 Pro Ser Met Leu Asp Ala Val Leu Gly Val Met Asp Ala Ala Arg Pro
             100                 105                 110        
 Glu Ala Ala Ala Ala Lys Pro Asp Ala Glu Pro Arg Pro Gly Thr Gln
         115                 120                 125            
 Pro Pro Gln Ala Arg Cys Arg Pro Asn Ala Asp Leu Glu Leu Asn Asp
     130                 135                 140                
 Val Ile Gly Leu
 145            



      <210> 931
      <211> 764
      <212> PRT
      <213> Homo sapiens


      <400> 931
 Met Asn Leu Leu Pro Lys Ala Trp Gly Val Pro Gln Asp Leu Ile Lys
   1               5                  10                  15    
 Lys Tyr Ile Lys Leu Glu Glu Asp Gly Gly Cys Val Ile Gly Gly Asp
              20                  25                  30        
 Arg Ser Leu Gln Asp Lys Tyr Leu Leu Arg Leu Val Ala Ala Met Glu
          35                  40                  45            
 Glu Val Phe Met Asp Lys His Gly Ile His Pro Ser Leu Val Ala Asp
      50                  55                  60                
 Val His Gln Tyr Phe Tyr Arg Arg Thr Gly Val Ile Gly Val Gln Pro
  65                  70                  75                  80
 Glu Glu Val Thr Ala Ala Ala Lys Lys Ala Val Met Asp Asn Arg Leu
                  85                  90                  95    
 His Lys Cys Leu Leu Cys Gly Ala Leu Ser Glu Leu His Val Pro Pro
             100                 105                 110        
 Glu Trp Leu Ala Pro Gly Gly Lys Leu Tyr Asn Leu Ala Lys Ser Thr
         115                 120                 125            
 His Gly Gln Leu Arg Thr Asp Lys Asn Tyr Ser Phe Pro Leu Asn Asn
     130                 135                 140                
 Leu Val Cys Ser Tyr Asp Ser Val Lys Asp Val Leu Val Pro Asp Tyr
 145                 150                 155                 160
 Gly Met Ser Asn Leu Thr Ala Cys Asn Trp Cys His Gly Thr Ser Val
                 165                 170                 175    
 Arg Lys Val Arg Gly Asp Gly Ser Ile Val Tyr Leu Asp Gly Asp Arg
             180                 185                 190        
 Thr Asn Ser Arg Ser Thr Gly Gly Lys Cys Gly Cys Gly Phe Lys His
         195                 200                 205            
 Phe Trp Asp Gly Lys Glu Tyr Asp Asn Leu Pro Glu Ala Phe Pro Ile
     210                 215                 220                
 Thr Leu Glu Trp Gly Gly Arg Val Val Arg Glu Thr Val Tyr Trp Phe
 225                 230                 235                 240
 Gln Tyr Glu Ser Asp Ser Ser Leu Asn Ser Asn Val Tyr Asp Val Ala
                 245                 250                 255    
 Met Lys Leu Val Thr Lys His Phe Pro Gly Glu Phe Gly Ser Glu Ile
             260                 265                 270        
 Leu Val Gln Lys Val Val His Thr Ile Leu His Gln Thr Ala Lys Lys
         275                 280                 285            
 Asn Pro Asp Asp Tyr Thr Pro Val Asn Ile Asp Gly Ala His Ala Gln
     290                 295                 300                
 Arg Val Gly Asp Val Gln Gly Gln Glu Ser Glu Ser Gln Leu Pro Thr
 305                 310                 315                 320
 Lys Ile Ile Leu Thr Gly Gln Lys Thr Lys Thr Leu His Lys Glu Glu
                 325                 330                 335    
 Leu Asn Met Ser Lys Thr Glu Arg Thr Ile Gln Gln Asn Ile Thr Glu
             340                 345                 350        
 Gln Ala Ser Val Met Gln Lys Arg Lys Thr Glu Lys Leu Lys Gln Glu
         355                 360                 365            
 Gln Lys Gly Gln Pro Arg Thr Val Ser Pro Ser Thr Ile Arg Asp Gly
     370                 375                 380                
 Pro Ser Ser Ala Pro Ala Thr Pro Thr Lys Ala Pro Tyr Ser Pro Thr
 385                 390                 395                 400
 Thr Ser Lys Glu Lys Lys Ile Arg Ile Thr Thr Asn Asp Gly Arg Gln
                 405                 410                 415    
 Ser Met Val Thr Leu Lys Ser Ser Thr Thr Phe Phe Glu Leu Gln Glu
             420                 425                 430        
 Ser Ile Ala Arg Glu Phe Asn Ile Pro Pro Tyr Leu Gln Cys Ile Arg
         435                 440                 445            
 Tyr Gly Phe Pro Pro Lys Glu Leu Met Pro Pro Gln Ala Gly Met Glu
     450                 455                 460                
 Lys Glu Pro Val Pro Leu Gln His Gly Asp Arg Ile Thr Ile Glu Ile
 465                 470                 475                 480
 Leu Lys Ser Lys Ala Glu Gly Gly Gln Ser Ala Ala Ala His Ser Ala
                 485                 490                 495    
 His Thr Val Lys Gln Glu Asp Ile Ala Val Thr Gly Lys Leu Ser Ser
             500                 505                 510        
 Lys Glu Leu Gln Glu Gln Ala Glu Lys Glu Met Tyr Ser Leu Cys Leu
         515                 520                 525            
 Leu Ala Thr Leu Met Gly Glu Asp Val Trp Ser Tyr Ala Lys Gly Leu
     530                 535                 540                
 Pro His Met Phe Gln Gln Gly Gly Val Phe Tyr Ser Ile Met Lys Lys
 545                 550                 555                 560
 Thr Met Gly Met Ala Asp Gly Lys His Cys Thr Phe Pro His Leu Pro
                 565                 570                 575    
 Gly Lys Thr Phe Val Tyr Asn Ala Ser Glu Asp Arg Leu Glu Leu Cys
             580                 585                 590        
 Val Asp Ala Ala Gly His Phe Pro Ile Gly Pro Asp Val Glu Asp Leu
         595                 600                 605            
 Val Lys Glu Ala Val Ser Gln Val Arg Ala Glu Ala Thr Thr Arg Ser
     610                 615                 620                
 Arg Glu Ser Ser Pro Ser His Gly Leu Leu Lys Leu Gly Ser Gly Gly
 625                 630                 635                 640
 Val Val Lys Lys Lys Ser Glu Gln Leu His Asn Val Thr Ala Phe Gln
                 645                 650                 655    
 Gly Lys Gly His Ser Leu Gly Thr Ala Ser Gly Asn Pro His Leu Asp
             660                 665                 670        
 Pro Arg Ala Arg Glu Thr Ser Val Val Arg Lys His Asn Thr Gly Thr
         675                 680                 685            
 Asp Phe Ser Asn Ser Ser Thr Lys Thr Glu Pro Ser Val Phe Thr Ala
     690                 695                 700                
 Ser Ser Ser Asn Ser Glu Leu Ile Arg Ile Ala Pro Gly Val Val Thr
 705                 710                 715                 720
 Met Arg Asp Gly Arg Gln Leu Asp Pro Asp Leu Val Glu Ala Gln Arg
                 725                 730                 735    
 Lys Lys Ile Ala Gly Asn Gly Phe Phe Tyr Ser Gly Phe Asn Gly Gln
             740                 745                 750        
 Ala Pro Ser Gly Ser Lys Tyr Arg Ala Val Thr Ile
         755                 760                



      <210> 932
      <211> 207
      <212> PRT
      <213> Homo sapiens


      <400> 932
 Met Pro Pro Ile Pro Lys Lys Glu Thr Trp Val Val Gly Trp Ile Gln
   1               5                  10                  15    
 Ala Cys Ser His Met Glu Phe Tyr Asn Gln Tyr Gly Glu Gln Gly Met
              20                  25                  30        
 Ser Ser Trp Glu Leu Pro Asp Leu Gln Glu Gly Lys Ile Gln Ala Ile
          35                  40                  45            
 Ser Asp Ser Asp Gly Val Asn Tyr Pro Trp Tyr Gly Asn Thr Thr Glu
      50                  55                  60                
 Thr Cys Thr Ile Val Gly Pro Thr Lys Arg Asp Ser Lys Phe Ile Ile
  65                  70                  75                  80
 Ser Met Asn Asp Asn Phe Tyr Pro Ser Val Thr Trp Ala Val Pro Val
                  85                  90                  95    
 Ser Glu Ser Asn Val Ala Lys Leu Thr Asn Ile Tyr Arg Asp Gln Ser
             100                 105                 110        
 Phe Thr Thr Trp Leu Val Ala Thr Asn Thr Ser Thr Asn Asp Met Ile
         115                 120                 125            
 Ile Leu Gln Thr Leu His Trp Arg Met Gln Leu Ser Ile Glu Val Asn
     130                 135                 140                
 Pro Asn Arg Pro Leu Gly Gln Arg Ala Arg Leu Arg Glu Pro Ile Ala
 145                 150                 155                 160
 Gln Asp Gln Pro Lys Ile Leu Ser Lys Asn Glu Pro Ile Pro Pro Ser
                 165                 170                 175    
 Ala Leu Val Lys Pro Asn Ala Asn Asp Ala Gln Val Leu Met Trp Arg
             180                 185                 190        
 Pro Lys Tyr Gly Gln Pro Leu Val Val Ile Pro Pro Lys His Arg
         195                 200                 205        



      <210> 933
      <211> 374
      <212> PRT
      <213> Homo sapiens


      <400> 933
 Met Leu Thr Ala Ala Cys Pro Arg Gly His Leu Val Trp Gly His Asp
   1               5                  10                  15    
 Pro Tyr Trp Lys Lys Gly Asp Cys Gly Asn Val Leu Pro Glu Val Arg
              20                  25                  30        
 Asp Leu Val Gly Met Leu Gln Ser Leu Thr Ser Ser Leu Arg Gln Ala
          35                  40                  45            
 Ala Gly Asp Trp Leu Gly Met Cys Asp His Ile Pro Ala Val Ser Ala
      50                  55                  60                
 Cys Ser Gln Pro Glu Asp Asn Asp Leu Tyr Asp Ala Ile Thr Arg Gly
  65                  70                  75                  80
 Leu His Gln Thr Ile Val Asp Pro Glu Asn Pro Pro Ala Thr Ala Phe
                  85                  90                  95    
 Leu Thr Val Val Pro Asp Lys Ala Ala Ser Pro Arg Ser Ser Pro Lys
             100                 105                 110        
 Pro Gln Val Ser Phe Leu His Ala Gln Lys Ser Leu Asp Val Ser Pro
         115                 120                 125            
 Arg Asn Leu Ser Gln Glu Glu Ser Met Glu Ala Pro Ile Arg Val Ser
     130                 135                 140                
 Pro Leu Pro Glu Lys Ser Ser Ser Leu Leu Glu Glu Ser Phe Gly Gly
 145                 150                 155                 160
 Pro Ser Asp Ile Ile Tyr Ala Asp Leu Arg Arg Met Asn Gln Ala Arg
                 165                 170                 175    
 Leu Gly Leu Gly Thr Glu Gly Ser Gly Arg His Gly Pro Val Pro Ala
             180                 185                 190        
 Gly Ser Gln Ala Tyr Ser Pro Gly Arg Glu Ala Gln Arg Arg Leu Ser
         195                 200                 205            
 Asp Gly Glu Gln Asn Arg Pro Asp Gly Leu Gly Pro Val Leu Ser Gly
     210                 215                 220                
 Val Ser Pro Asp Gln Gly Pro Thr Glu Ser Pro Thr Ser Trp Gly Cys
 225                 230                 235                 240
 Ser Asp Ala Met Gly Ser Leu Gly Ala Thr Trp Arg Gln Glu Phe Pro
                 245                 250                 255    
 Lys Leu Ser Gln Glu Ala Gln Pro Cys Ser Gln Gly Ser Ser Ala Asp
             260                 265                 270        
 Ile Tyr Glu Phe Ile Gly Thr Glu Gly Leu Leu Gln Glu Ala Arg Asp
         275                 280                 285            
 Thr Pro Asp Gln Glu Gly Ser Thr Tyr Glu Gln Ile Pro Ala Cys Trp
     290                 295                 300                
 Gly Gly Pro Ala Arg Ala Pro His Pro Gly Ala Ser Pro Thr Tyr Ser
 305                 310                 315                 320
 Pro Trp Val His Gly Tyr Lys Arg Ile Ser Gly Thr Pro Glu Leu Ser
                 325                 330                 335    
 Glu Pro Gly Asn Thr Tyr Glu Gln Ile Pro Ala Thr Lys Ser Lys Glu
             340                 345                 350        
 Thr Gly Arg Thr His Lys Pro Asp Lys Leu Arg Arg Leu Phe Phe Thr
         355                 360                 365            
 Tyr Arg Lys His Lys Phe
     370                



      <210> 934
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 934
 Met Glu Val Glu Glu Gly Glu Leu Glu Ile Val Pro Val Arg Arg Ser
   1               5                  10                  15    
 Leu Lys Glu Leu Ile Pro Asp Thr Ser Arg Arg Tyr Glu Asn Lys Ala
              20                  25                  30        
 Gly Ser Phe Ile Thr Gly Ile Asp Val Thr Ser Lys Glu Ala Ile Glu
          35                  40                  45            
 Lys Lys Glu Gln Arg Ala Lys Arg Phe His Phe Arg Ser Glu Val Asn
      50                  55                  60                
 Leu Ala Gln Arg Asn Val Ala Leu Asp Arg Asp Met Met Lys Lys Ala
  65                  70                  75                  80
 Ile Pro Lys Val Arg Leu Glu Thr Ile Tyr Ile Cys Gly Val Asp Glu
                  85                  90                  95    
 Met Ser Thr Gln Asp Val Phe Ser Tyr Phe Lys Glu Tyr Pro Pro Ala
             100                 105                 110        
 His Ile Glu Cys Leu Asp Asp Thr Ser Cys Lys Tyr Thr Arg Phe Pro
         115                 120                 125            





      <210> 935
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 935
 Met Ala Leu Glu Met Val Trp Gly Ser Val Tyr His Cys Ser Cys Tyr
   1               5                  10                  15    
 Ile Thr Pro Trp Ser Lys Ile Gln Ser Phe Ser Leu Ser Leu Phe Gln
              20                  25                  30        
 Phe Ile Leu Gln Glu Val Asn Ile Thr Leu Pro Glu Asn Ser Val Trp
          35                  40                  45            
 Tyr Glu Arg Tyr Lys Phe Asp Ile Pro Val Phe His Leu Asn Gly Gln
      50                  55                  60                
 Phe Leu Met Met His Arg Val Asn Thr Ser Lys Leu Glu Lys Gln Leu
  65                  70                  75                  80
 Leu Lys Leu Glu Gln Gln Ser Thr Gly Gly
                  85                  90



      <210> 936
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 936
 Met Asn Glu Thr Lys Asp Glu Pro Asp Tyr Leu Val Thr His Arg Arg
   1               5                  10                  15    
 Arg Thr Ser Ser Ser Gly Asn Gln Ile Leu Phe Gln Ala Trp His Ile
              20                  25                  30        
 Lys Gly Lys Lys Gly Ser Glu Arg Arg Val Arg Lys Tyr His Leu Lys
          35                  40                  45            
 Pro Gln Lys Ile Trp Gln Lys Thr Ala Ser Gln Ser Ile Arg
      50                  55                  60        



      <210> 937
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 937
 Met Ala Ala Ser Ser Ser Ser Ser Ser Ala Gly Gly Val Ser Gly Ser
   1               5                  10                  15    
 Ser Val Thr Gly Ser Gly Phe Ser Val Ser Asp Leu Ala Pro Pro Arg
              20                  25                  30        
 Lys Ala Leu Phe Thr Tyr Pro Lys Gly Ala Gly Glu Met Leu Glu Asp
          35                  40                  45            
 Gly Ser Glu Arg Phe Leu Cys Glu Ser Val Phe Ser Tyr Gln Val Ala
      50                  55                  60                
 Ser Thr Leu Lys Gln Val Lys His Asp Gln Gln Val Ala Arg Met Glu
  65                  70                  75                  80
 Lys Leu Ala Gly Leu Val Glu Glu Leu Glu Ala Asp Glu Trp Arg Phe
                  85                  90                  95    
 Lys Pro Ile Glu Gln Leu Leu Gly Phe Thr Pro Ser Ser Gly
             100                 105                 110



      <210> 938
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 938
 Met Gly Leu Ala Gly Val Cys Ala Leu Arg Arg Ser Ala Gly Tyr Ile
   1               5                  10                  15    
 Leu Val Gly Gly Ala Gly Gly Gln Ser Ala Ala Ala Ala Ala Arg Arg
              20                  25                  30        
 Cys Ser Glu Gly Glu Trp Ala Ser Gly Gly Val Arg Ser Phe Ser Arg
          35                  40                  45            
 Ala Ala Ala Ala Met Ala Pro Ile Lys Val Gly Asp Ala Ile Pro Ala
      50                  55                  60                
 Val Glu Val Phe Glu Gly Glu Pro Gly Asn Lys Val Asn Leu Ala Glu
  65                  70                  75                  80
 Leu Phe Lys Gly Lys Lys Gly Val Leu Phe Gly Val Pro Gly Ala Phe
                  85                  90                  95    
 Thr Pro Gly Cys Ser Lys Thr His Leu Pro Gly Phe Val Glu Gln Ala
             100                 105                 110        
 Glu Ala Leu Lys Ala Lys Gly Val Gln Val Val Ala Cys Leu Ser Val
         115                 120                 125            
 Asn Asp Ala Phe Val Thr Gly Ala Phe Gly Lys Glu Thr Asp Leu Leu
     130                 135                 140                
 Leu Asp Asp Ser Leu Val Ser Ile Phe Gly Asn Arg Arg Leu Lys Arg
 145                 150                 155                 160
 Phe Ser Met Val Val Gln Asp Gly Ile Val Lys Ala Leu Asn Val Glu
                 165                 170                 175    
 Pro Asp Gly Thr Gly Leu Thr Cys Ser Leu Ala Pro Asn Ile Ile Ser
             180                 185                 190        
 Gln Leu
        



      <210> 939
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 939
 Met Gly Leu Ala Gly Val Cys Ala Leu Arg Arg Ser Ala Gly Tyr Ile
   1               5                  10                  15    
 Leu Val Gly Gly Ala Gly Gly Gln Ser Ala Ala Ala Ala Ala Arg Arg
              20                  25                  30        
 Cys Ser Glu Glu Glu Trp Ala Ser Gly Gly Val His Ser Phe Ser Arg
          35                  40                  45            
 Ala Ala Ala Ala Met Ala Pro Ile Lys Thr His Leu Pro Gly Phe Val
      50                  55                  60                
 Glu Gln Ala Glu Ala Leu Lys Ala Lys Gly Ser Pro Gly Gly Gly Leu
  65                  70                  75                  80
 Ser Glu Cys
            



      <210> 940
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 940
 Met Gly Leu Ala Gly Val Cys Ala Leu Arg Arg Ser Ala Gly Tyr Ile
   1               5                  10                  15    
 Leu Val Gly Gly Ala Gly Gly Gln Ser Ala Ala Ala Ala Ala Arg Arg
              20                  25                  30        
 Cys Ser Glu Gly Glu Trp Ala Ser Gly Gly Val Arg Ser Phe Ser Arg
          35                  40                  45            
 Ala Ala Ala Ala Met Ala Pro Ile Lys Val Gly Asp Ala Ile Pro Ala
      50                  55                  60                
 Val Glu Val Phe Glu Gly Glu Pro Gly Asn Lys Val Asn Leu Ala Glu
  65                  70                  75                  80
 Leu Phe Lys Gly Lys Lys Gly Val Leu Phe Gly Val Pro Gly Ala Phe
                  85                  90                  95    
 Thr Pro Gly Cys Ser Lys Val Arg Leu Leu Ala Asp Pro Thr Gly Ala
             100                 105                 110        
 Phe Gly Lys Glu Thr Asp Leu Leu Leu Asp Asp Ser Leu Val Ser Ile
         115                 120                 125            
 Phe Gly Asn Arg Arg Leu Lys Arg Phe Ser Met Val Val Gln Asp Gly
     130                 135                 140                
 Ile Val Lys Ala Leu Asn Val Glu Pro Asp Gly Thr Gly Leu Thr Cys
 145                 150                 155                 160
 Ser Leu Ala Pro Asn Ile Ile Ser Gln Leu
                 165                 170



      <210> 941
      <211> 290
      <212> PRT
      <213> Homo sapiens


      <400> 941
 Met Asp Lys His Ser Pro Cys Glu Ser Val Asn Leu Pro Ala Leu Ala
   1               5                  10                  15    
 Val Gly Arg Arg Arg Arg Pro His Lys His Ser Pro Cys Glu Ser Val
              20                  25                  30        
 Asn Leu Pro Val Leu Thr Val Gly Arg Arg Arg Ser Leu Asp Lys His
          35                  40                  45            
 Ser Pro Cys Glu Ser Val Asn Leu Pro Ala Leu Ala Val Gly His Arg
      50                  55                  60                
 Arg Ser Leu Asp Lys His Ser Pro Cys Glu Ser Val Asn Leu Pro Ala
  65                  70                  75                  80
 Leu Ala Val Gly His Arg Arg Ser Val Asp Lys His Ser Pro Cys Glu
                  85                  90                  95    
 Ser Val Asn Leu Pro Ala Phe Ala Val Gly Arg Arg Arg Arg Pro His
             100                 105                 110        
 Lys His Ser Pro Cys Glu Ser Val Asn Leu Pro Ala Leu Ala Val Gly
         115                 120                 125            
 Arg Cys Arg Ser Leu Asp Lys His Ser Pro Cys Glu Ser Val Asn Leu
     130                 135                 140                
 Pro Ala Leu Ala Val Gly Arg Arg Arg Ser Leu Asp Lys His Ser Pro
 145                 150                 155                 160
 Cys Glu Ser Val Asn Leu Pro Ala Leu Ala Val Gly His Arg Arg Ser
                 165                 170                 175    
 Val Asp Lys His Ser Pro Cys Glu Ser Val Asn Leu Pro Ala Phe Ala
             180                 185                 190        
 Val Gly Arg Arg Arg Arg Pro His Lys His Ser Pro Cys Glu Ser Val
         195                 200                 205            
 Asn Leu Pro Ala Leu Ala Ala Gly Arg Arg Arg Arg Pro His Lys His
     210                 215                 220                
 Ser Pro Cys Glu Ser Val Asn Leu Pro Ala Leu Ala Ala Gly Arg Arg
 225                 230                 235                 240
 Arg Arg Pro His Lys His Ser Pro Gly Glu Ser Val Asn Leu Pro Ala
                 245                 250                 255    
 Leu Ala Val Gly Arg Arg Arg Ser Val Asp Lys His Ser Pro Cys Glu
             260                 265                 270        
 Ser Val Asn Leu Pro Ala Leu Ala Val Gly Arg Arg Arg Ser Gly Trp
         275                 280                 285            
 Pro Ser
     290



      <210> 942
      <211> 1127
      <212> PRT
      <213> Homo sapiens


      <400> 942
 Met Ser Leu Thr Ser Ala Tyr Gln His Lys Leu Ala Glu Lys Leu Thr
   1               5                  10                  15    
 Ile Leu Asn Asp Arg Gly Gln Gly Val Leu Ile Arg Met Tyr Asn Ile
              20                  25                  30        
 Lys Lys Thr Cys Ser Asp Pro Lys Ser Lys Pro Pro Phe Leu Leu Glu
          35                  40                  45            
 Lys Ser Met Glu Pro Ser Leu Lys Tyr Ile Asn Lys Lys Phe Pro Asn
      50                  55                  60                
 Ile Asp Val Arg Asn Ser Thr Gln His Leu Gly Pro Val His Arg Glu
  65                  70                  75                  80
 Lys Ala Glu Ile Ile Arg Phe Leu Thr Asn Tyr Tyr Gln Ser Phe Val
                  85                  90                  95    
 Asp Val Met Glu Phe Arg Asp His Val Tyr Glu Leu Leu Asn Thr Ile
             100                 105                 110        
 Asp Ala Cys Gln Cys His Phe Asp Ile Asn Leu Asn Phe Asp Phe Thr
         115                 120                 125            
 Arg Ser Tyr Leu Asp Leu Ile Val Thr Tyr Thr Ser Val Ile Leu Leu
     130                 135                 140                
 Leu Ser Arg Ile Glu Asp Arg Arg Ile Leu Ile Gly Met Tyr Asn Cys
 145                 150                 155                 160
 Ala His Glu Met Leu His Gly His Gly Asp Pro Ser Phe Ala Arg Leu
                 165                 170                 175    
 Gly Gln Met Val Leu Glu Tyr Asp His Pro Leu Lys Lys Leu Thr Glu
             180                 185                 190        
 Glu Phe Gly Pro His Thr Lys Ala Val Ser Gly Ala Leu Leu Ser Leu
         195                 200                 205            
 His Phe Leu Phe Val Arg Arg Asn Gln Gly Ala Glu Gln Trp Arg Ser
     210                 215                 220                
 Ala Gln Leu Leu Ser Leu Ile Ser Asn Pro Pro Ala Met Ile Asn Pro
 225                 230                 235                 240
 Ala Asn Ser Asp Thr Met Ala Cys Glu Tyr Leu Ser Val Glu Val Met
                 245                 250                 255    
 Glu Arg Trp Ile Ile Ile Gly Phe Leu Leu Cys His Gly Cys Leu Asn
             260                 265                 270        
 Ser Asn Ser Gln Cys Gln Lys Leu Trp Lys Leu Cys Leu Gln Gly Ser
         275                 280                 285            
 Leu Tyr Ile Thr Leu Ile Arg Glu Asp Val Leu Gln Val His Lys Val
     290                 295                 300                
 Thr Glu Asp Leu Phe Ser Ser Leu Lys Gly Tyr Gly Lys Arg Val Ala
 305                 310                 315                 320
 Asp Ile Lys Glu Ser Lys Glu His Val Ile Ala Asn Ser Gly Gln Phe
                 325                 330                 335    
 His Cys Gln Arg Arg Gln Phe Leu Arg Met Ala Val Lys Glu Leu Glu
             340                 345                 350        
 Thr Val Leu Ala Asp Glu Pro Gly Leu Leu Gly Pro Lys Ala Leu Phe
         355                 360                 365            
 Ala Phe Met Ala Leu Ser Phe Ile Arg Asp Glu Val Thr Trp Leu Val
     370                 375                 380                
 Arg His Thr Glu Asn Val Thr Lys Thr Lys Thr Pro Glu Asp Tyr Ala
 385                 390                 395                 400
 Asp Ser Ser Ile Ala Glu Leu Leu Phe Leu Leu Glu Gly Ile Arg Ser
                 405                 410                 415    
 Leu Val Arg Arg His Ile Lys Val Ile Gln Gln Tyr His Leu Gln Tyr
             420                 425                 430        
 Leu Ala Arg Phe Asp Ala Leu Val Leu Ser Asp Ile Ile Gln Asn Leu
         435                 440                 445            
 Ser Val Cys Pro Glu Glu Glu Ser Ile Ile Met Ser Ser Phe Val Ser
     450                 455                 460                
 Ile Leu Ser Ser Leu Asn Leu Lys Gln Val Asp Asn Gly Glu Lys Phe
 465                 470                 475                 480
 Glu Phe Ser Gly Leu Arg Leu Asp Trp Phe Arg Leu Gln Ala Tyr His
                 485                 490                 495    
 Ser Val Ala Lys Ala Pro Leu His Leu His Glu Asn Pro Asp Leu Ala
             500                 505                 510        
 Lys Val Met Asn Leu Ile Val Phe His Ser Arg Met Leu Asp Ser Val
         515                 520                 525            
 Glu Lys Leu Leu Val Glu Thr Ser Asp Leu Ser Thr Phe Cys Phe His
     530                 535                 540                
 Leu Arg Ile Phe Glu Lys Met Phe Ala Met Thr Leu Glu Glu Ser Ala
 545                 550                 555                 560
 Met Leu Arg Tyr Ala Ile Ala Phe Pro Leu Ile Cys Ala His Phe Val
                 565                 570                 575    
 His Cys Thr His Glu Met Cys Pro Glu Glu Tyr Pro His Leu Lys Asn
             580                 585                 590        
 His Gly Leu His His Cys Asn Ser Phe Leu Glu Glu Leu Ala Lys Gln
         595                 600                 605            
 Thr Ser Asn Cys Val Leu Glu Ile Cys Ala Glu Gln Arg Asn Leu Ser
     610                 615                 620                
 Glu Gln Leu Leu Pro Lys His Cys Ala Thr Thr Ile Ser Lys Ala Lys
 625                 630                 635                 640
 Asn Lys Lys Thr Arg Lys Gln Arg Gln Thr Pro Arg Lys Gly Glu Pro
                 645                 650                 655    
 Glu Arg Asp Lys Pro Gly Ala Glu Ser His Arg Lys Asn Arg Ser Ile
             660                 665                 670        
 Val Thr Asn Met Asp Lys Leu His Leu Asn Leu Thr Glu Leu Ala Leu
         675                 680                 685            
 Thr Met Asn His Val Tyr Ser Phe Ser Val Phe Glu His Thr Ile Phe
     690                 695                 700                
 Pro Ser Glu Tyr Leu Ser Ser His Leu Glu Ala Arg Leu Asn Arg Ala
 705                 710                 715                 720
 Ile Val Trp Leu Ala Gly Tyr Asn Ala Thr Thr Gln Glu Ile Val Arg
                 725                 730                 735    
 Pro Ser Glu Leu Leu Ala Gly Val Lys Ala Tyr Ile Gly Phe Ile Gln
             740                 745                 750        
 Ser Leu Ala Gln Phe Leu Gly Ala Asp Ala Ser Arg Val Ile Arg Lys
         755                 760                 765            
 Pro Leu Leu Gln Gln Thr Gln Pro Leu Asp Ser Cys Gly Glu Gln Thr
     770                 775                 780                
 Ile Thr Thr Leu Tyr Thr Asn Trp Tyr Leu Glu Ser Leu Leu Arg Gln
 785                 790                 795                 800
 Ala Ser Ser Gly Thr Ile Ile Leu Ser Pro Ala Met Gln Ala Phe Val
                 805                 810                 815    
 Ser Leu Pro Arg Glu Gly Glu Gln Asn Phe Ser Ala Glu Glu Phe Ser
             820                 825                 830        
 Asp Ile Ser Glu Met Arg Ala Leu Ala Glu Leu Leu Gly Pro Tyr Gly
         835                 840                 845            
 Met Lys Phe Leu Ser Glu Asn Leu Met Trp His Val Thr Ser Gln Ile
     850                 855                 860                
 Val Glu Leu Lys Lys Leu Val Val Glu Asn Met Asp Ile Leu Val Gln
 865                 870                 875                 880
 Ile Arg Ser Asn Phe Ser Lys Pro Asp Leu Met Ala Ser Leu Leu Pro
                 885                 890                 895    
 Gln Leu Thr Gly Ala Glu Asn Val Leu Lys Arg Met Thr Ile Ile Gly
             900                 905                 910        
 Val Ile Leu Ser Phe Arg Ala Met Ala Gln Glu Gly Leu Arg Glu Val
         915                 920                 925            
 Phe Ser Ser His Cys Pro Phe Leu Met Gly Pro Ile Glu Cys Leu Lys
     930                 935                 940                
 Glu Phe Val Thr Pro Asp Thr Asp Ile Lys Val Thr Leu Ser Ile Phe
 945                 950                 955                 960
 Glu Leu Ala Ser Ala Ala Gly Val Gly Cys Asp Ile Asp Pro Ala Leu
                 965                 970                 975    
 Val Ala Ala Ile Ala Asn Leu Lys Ala Asp Thr Ser Ser Pro Glu Glu
             980                 985                 990        
 Glu Tyr Lys Val Ala Cys Leu Leu Leu Ile Phe Leu Ala Val Ser Leu
         995                1000                1005            
 Pro Leu Leu Ala Thr Asp Pro Ser Ser Phe Tyr Ser Ile Glu Lys Asp
    1010                1015                1020                
 Gly Tyr Asn Asn Asn Ile His Cys Leu Thr Lys Ala Ile Ile Gln Val
1025                1030                1035                1040
 Ser Ala Ala Leu Phe Thr Leu Tyr Asn Lys Asn Ile Glu Thr His Leu
                1045                1050                1055    
 Lys Glu Phe Leu Val Val Ala Ser Val Ser Leu Leu Gln Leu Gly Gln
            1060                1065                1070        
 Glu Thr Asp Lys Leu Lys Thr Arg Asn Arg Glu Ser Ile Ser Leu Leu
        1075                1080                1085            
 Met Arg Leu Val Val Glu Glu Ser Ser Phe Leu Thr Leu Asp Met Leu
    1090                1095                1100                
 Glu Ser Cys Phe Pro Tyr Val Leu Leu Arg Asn Ala Tyr Arg Glu Val
1105                1110                1115                1120
 Ser Arg Ala Phe His Leu Asn
                1125        



      <210> 943
      <211> 431
      <212> PRT
      <213> Homo sapiens


      <400> 943
 Met Ser Ser Ser Leu Arg Pro Gly Pro Ser Arg Trp Arg Arg Ala Ala
   1               5                  10                  15    
 Ser Ile Val Leu Ala Ala Gly Trp Ser Arg Pro Glu Thr Ala Thr Pro
              20                  25                  30        
 Pro Ser Arg Pro Pro Pro Ala Glu Gly Phe Arg Leu Leu Leu Leu Gln
          35                  40                  45            
 Arg Ser Pro His Gln Gly Phe Met Pro Gly Ala His Val Phe Ser Gly
      50                  55                  60                
 Gly Val Leu Asp Ala Ala Asp Arg Ser Ala Asp Trp Leu Gly Leu Phe
  65                  70                  75                  80
 Ala Pro His His Gly Pro Pro Arg Phe Gly Leu Gly Pro Ala Pro Phe
                  85                  90                  95    
 Ser Arg Thr Ala Phe Pro Ser Leu Pro Asp Thr Asp Asp His Lys Thr
             100                 105                 110        
 Asp Asn Thr Gly Thr Leu Pro Glu Asp Val Ala Phe Arg Ile Cys Ala
         115                 120                 125            
 Val Arg Glu Ala Phe Glu Glu Ala Gly Val Leu Leu Leu Arg Pro Arg
     130                 135                 140                
 Thr Ser Pro Pro Gly Pro Ala Pro Gly Pro Gly Leu Ala Leu Glu Pro
 145                 150                 155                 160
 Pro Pro Gly Leu Ala Ser Trp Arg Asp Arg Val Arg Gln Asp Pro Arg
                 165                 170                 175    
 His Phe Leu Arg Leu Cys Ala His Leu Asp Cys Thr Pro Asp Ile Trp
             180                 185                 190        
 Ala Leu His Asn Trp Ser Ala Trp Leu Thr Pro Phe Leu Arg Gly Thr
         195                 200                 205            
 Thr Arg Arg Phe Asp Thr Ala Phe Phe Leu Cys Cys Leu Arg Glu Pro
     210                 215                 220                
 Pro Pro Val Tyr Pro Asp Leu Ala Glu Val Val Gly Tyr Gln Trp Ser
 225                 230                 235                 240
 Ser Pro Ser Glu Ala Thr Glu Ser Phe Leu Ser Lys Glu Ile Trp Leu
                 245                 250                 255    
 Pro Pro Pro Gln Phe Tyr Glu Val Arg Arg Leu Ala Asn Phe Ala Ser
             260                 265                 270        
 Leu Ser Asp Leu His Lys Phe Cys Leu Gly Arg Ala Leu Glu Gly Leu
         275                 280                 285            
 Glu Arg Trp Leu Pro Ile Ile Leu Leu Thr Ala Asp Gly Met Val His
     290                 295                 300                
 Leu Leu Pro Gly Asp Glu Leu Tyr Leu Glu Asp Ser Asp Phe Leu Glu
 305                 310                 315                 320
 Asn Leu Met Ser Thr Glu Lys Lys Thr Glu Glu Ile Met Lys Glu Gly
                 325                 330                 335    
 Lys Gln Phe His Arg Ile Val Thr Tyr His Arg His Leu Tyr Asp Ile
             340                 345                 350        
 His Val Thr Val Gln Pro Lys Tyr Lys His Val Tyr Pro Lys Asn Ser
         355                 360                 365            
 Val Gln Ile Asn Ser Phe Arg Leu Gly Glu Pro Cys Gln Leu Lys Ser
     370                 375                 380                
 Ser Trp Glu Glu Ile Gln Asp Gln Glu Pro Phe Gln Lys Val Gln Ile
 385                 390                 395                 400
 Lys Trp Lys Cys Cys Gln Glu Ala Thr Lys Thr Gln Gly Phe Met Thr
                 405                 410                 415    
 Val Gln Asp Ser Ser Ser Pro Pro Arg Leu Pro Ala His Ser Val
             420                 425                 430    



      <210> 944
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 944
 Met Trp Leu Val Phe His Arg Pro His Pro Arg Pro Ser Trp Pro Leu
   1               5                  10                  15    
 Arg Ala Ala Leu Gly Phe Gly Arg Arg Gln Ser Ser Leu Arg Cys Phe
              20                  25                  30        
 Pro Val Leu Pro Ser Ala Arg Pro Tyr Val Ser Ala Asn Pro Thr Leu
          35                  40                  45            
 Arg Gly Gly Arg Leu Arg Gln Asp Pro Glu Ser Glu Thr Gly Val Gly
      50                  55                  60                
 Asp Leu Pro Asp Pro Val Thr Thr Leu Val Leu Leu His Asn Arg Leu
  65                  70                  75                  80
 Pro Leu Ala Val Thr Val Gly Cys Leu Pro Ser Arg Cys Pro Thr Glu
                  85                  90                  95    
 Lys Arg Ala Leu Pro Trp Gln Gly Leu Leu His Cys Leu Ala Val Asp
             100                 105                 110        
 Val Glu Val Gly Gln Glu Ser Glu Glu Lys Thr Glu Arg Arg Glu Val
         115                 120                 125            
 Glu Pro Thr Ser Glu Lys Arg Gly Gly Lys Phe Arg Trp Glu Val Asp
     130                 135                 140                
 Gly Ser Glu Glu Phe Glu Gln Thr Pro Thr Val Lys Glu Ser Asp Leu
 145                 150                 155                 160
 Ser Lys Gln
            



      <210> 945
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 945
 Met Thr Leu Leu Pro Arg Leu Ala Leu Arg Glu Glu Glu Ala Arg Arg
   1               5                  10                  15    
 Gly Pro Leu Arg Ala Pro Val Gln Pro Gly Leu Gly Glu Arg Ser Pro
              20                  25                  30        
 Gln Arg His Arg Glu Pro Lys Gln Gly Arg Val Ser Gln Arg Trp His
          35                  40                  45            
 Pro Ala Arg Glu Pro Leu Ala Ala Thr Gly Phe Leu His Gly Leu Gly
      50                  55                  60                
 His Leu Gly Arg Ala Ala Gln Ser Pro Arg Ala Ser Cys Cys Ile Leu
  65                  70                  75                  80
 Trp Pro Gly Thr Trp Gly Asp Pro Leu Arg Thr Leu Gly Arg Ser Gln
                  85                  90                  95    
 Arg Glu Val Gln Thr Val Cys Thr Gly Val Ser Gly Asp Gln Ala Gln
             100                 105                 110        
 Lys Glu Gln Asp Gly His Leu Leu Ala Trp Arg Lys Ile Leu Leu Pro
         115                 120                 125            
 Gly Lys Lys Thr Thr Pro Arg Gly Ile Gly Leu Gly Cys Arg Thr Leu
     130                 135                 140                
 Ser Gln Ala Thr Ala Pro Phe Leu Leu Gln Asn Trp Gly Arg Lys Arg
 145                 150                 155                 160
 Ala Phe Arg Pro Gly Ser Glu Asn Pro Ser Ser Gly Thr Ser Arg Pro
                 165                 170                 175    
 Ser Arg Gly Arg Leu Glu Ala Arg Ser Ser Gly Leu Asp Glu Ala Trp
             180                 185                 190        
 Glu Ala Gln Arg Leu Thr Gly His Gly Arg Phe Pro Ser Pro Arg Lys
         195                 200                 205            
 Glu Lys Ser Leu Gln Arg Gly Leu Gly
     210                 215        



      <210> 946
      <211> 204
      <212> PRT
      <213> Homo sapiens


      <400> 946
 Met Gly Lys Pro Gly Pro Pro Leu Pro Ser Leu Ser Leu Phe Cys Pro
   1               5                  10                  15    
 Ser Thr Gln Pro Asp Lys Ser Asp Ser Gln Leu Ala Pro Met Pro Pro
              20                  25                  30        
 Ala Leu Pro Ala Asp Leu Val Leu Tyr Leu Arg Val Leu Asp Ile Tyr
          35                  40                  45            
 His Thr Gly Ala Gln Ser His Gly Arg Gly Trp Pro Pro Ser Pro Gly
      50                  55                  60                
 Pro Asp Asn Leu Pro Ser Arg His Pro Asn Leu Pro Glu Pro Gln Ser
  65                  70                  75                  80
 Pro Leu Ser Asn Lys Val Ile Cys Arg Tyr Ser Gly Gly Leu Glu Asn
                  85                  90                  95    
 Ile Glu Trp Val Pro Gln Ser Thr Val Ser Val Thr Gly Arg Ser Tyr
             100                 105                 110        
 Lys Cys Val Leu Lys Trp Asn Pro Phe Phe Phe Ser Ser Asn His Lys
         115                 120                 125            
 Asp His Asn His Pro Lys Ser Lys Glu Ser Leu Arg His Ser Ser Ser
     130                 135                 140                
 Ala Ser Ser Cys Arg Lys Ser Pro Pro Gln Gly Glu Arg Ser Val Phe
 145                 150                 155                 160
 Thr Arg Thr Gly Ile Gln Cys Asp Leu Val Val Glu Ser Leu Ser Phe
                 165                 170                 175    
 Ser Leu Pro Ser Leu Ser Ala Val Pro Glu Ala Cys Gln Leu Pro Leu
             180                 185                 190        
 Ser Phe Leu Leu Cys Pro Gln Arg Ser Met Gly Pro
         195                 200                



      <210> 947
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 947
 Met Asp Met Lys Ser Asn Thr Gly His Gly Leu Phe Leu Gly Arg Gln
   1               5                  10                  15    
 Pro Ser Phe Ser Val Trp Ser Met Pro Gly Thr Pro Ala Leu Ala Ile
              20                  25                  30        
 Cys Gln Pro His Asn Pro Gly Pro Pro Met Gly Thr Pro Thr Glu Asp
          35                  40                  45            
 Pro Ser Gly Cys Ser Phe Pro Cys Leu Phe Leu Ser Pro Gln Ser Phe
      50                  55                  60                
 Leu Val Leu Ser Trp Ala Ile Ser Arg Leu Pro Ser Leu Phe Leu Leu
  65                  70                  75                  80
 Ser Gly Leu Cys Pro Gln Lys Pro Gln Thr Ser Ser Pro Cys Thr Gln
                  85                  90                  95    
 Ser Lys Gly
            



      <210> 948
      <211> 280
      <212> PRT
      <213> Homo sapiens


      <400> 948
 Met Lys Asn Pro Gly Glu Gln Ile Pro Glu Pro Glu Asn Gly Ala Glu
   1               5                  10                  15    
 Glu Pro Ala Lys Glu Asp Lys Glu Val Gly Thr Gly Lys Lys Thr Trp
              20                  25                  30        
 Val Arg Ala Arg Ile Asp Ile His Leu His Asn Phe Tyr Gln Val Cys
          35                  40                  45            
 Gln Glu Leu Gly Ser Thr Arg Glu Thr Gln Val Glu Ser Pro His Pro
      50                  55                  60                
 Cys Pro Pro Gly Asp Arg Lys Thr Tyr Gly Tyr Asn Ser Arg Asp Lys
  65                  70                  75                  80
 Ser Asp Ala Cys Glu Asp Trp Ala Phe Ile Asn Thr Asn Ile Phe Ala
                  85                  90                  95    
 Arg Thr Lys Ile Asp Pro Ser Ala Leu Val Gln Lys Leu Glu Leu Asp
             100                 105                 110        
 Val Arg Ser Val Thr Ser Ile Arg Arg Gly Ala Glu Ala Lys Thr Val
         115                 120                 125            
 Leu Pro Lys Glu Lys Met Lys Leu Arg Arg Glu Gln Trp Leu Gln Lys
     130                 135                 140                
 Ile Glu Ala Ile Lys Leu Ala Glu Gln Lys His Arg Glu Glu Arg Arg
 145                 150                 155                 160
 Arg Arg Ala Thr Val Val Val Gly Asp Leu His Pro Leu Arg Asp Ala
                 165                 170                 175    
 Leu Pro Glu Leu Leu Gly Leu Glu Ala Gly Ser Arg Arg Gln Ala Arg
             180                 185                 190        
 Arg Thr Pro Ser Pro Ser Asp Thr Thr Pro Pro Pro Ser Asp Ala Thr
         195                 200                 205            
 Pro Ser Asp Thr Thr Leu Pro Pro Gly Asp Ala Thr Pro Ser Asp Thr
     210                 215                 220                
 Thr Pro Ser Asp Ala Thr Pro Pro Pro Asn Glu Asp Thr Thr Thr Arg
 225                 230                 235                 240
 Glu Glu Glu Arg Thr Arg Phe Gln Glu Leu Leu Ala Ser Pro Ala Tyr
                 245                 250                 255    
 Arg Ala Ser Pro Leu Val Ala Ile Gly Gln Thr Leu Ala Arg Gln Met
             260                 265                 270        
 Gln Leu Glu Asp Gly Gly Gln Leu
         275                 280



      <210> 949
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 949
 Met Met Arg Arg Thr Leu Glu Asn Arg Asn Ala Gln Thr Lys Gln Leu
   1               5                  10                  15    
 Gln Thr Ala Val Ser Asn Val Glu Lys His Phe Gly Glu Leu Cys Gln
              20                  25                  30        
 Ile Phe Ala Ala Tyr Val Arg Lys Thr Ala Arg Leu Arg Asp Lys Ala
          35                  40                  45            
 Asp Leu Leu Val Asn Glu Ile Asn Ala Tyr Ala Ala Thr Glu Thr Pro
      50                  55                  60                
 His Leu Lys Leu Gly Leu Met Asn Phe Ala Asp Glu Phe Ala Lys Leu
  65                  70                  75                  80
 Gln Asp Tyr Arg Gln Ala Glu Val Glu Arg Leu Glu Ala Lys Val Val
                  85                  90                  95    
 Glu Pro Leu Lys Thr Tyr Gly Thr Ile Val Lys Met Lys Arg Asp Asp
             100                 105                 110        
 Leu Lys Ala Thr Leu Thr Ala Arg Asn Arg Glu Ala Lys Gln Leu Thr
         115                 120                 125            
 Gln Leu Glu Arg Thr Arg Gln Arg Asn Pro Ser Asp Arg His Val Ile
     130                 135                 140                
 Ser Gln Ala Glu Thr Glu Leu Gln Arg Ala Ala Met Asp Ala Ser Arg
 145                 150                 155                 160
 Thr Ser Arg His Leu Glu Glu Thr Ile Asn Asn Phe Glu Arg
                 165                 170                



      <210> 950
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 950
 Met Lys Arg Ser Gly Asn Pro Gly Ala Glu Val Thr Asn Ser Ser Val
   1               5                  10                  15    
 Ala Gly Pro Asp Cys Cys Gly Gly Leu Gly Asn Ile Asp Phe Arg Gln
              20                  25                  30        
 Ala Asp Phe Cys Val Met Thr Arg Leu Leu Gly Tyr Val Asp Pro Leu
          35                  40                  45            
 Asp Pro Ser Phe Val Ala Ala Val Ile Thr Ile Thr Phe Asn Pro Leu
      50                  55                  60                
 Tyr Trp Asn Val Val Ser Asp Val Pro Asp Thr Val Gln Thr Gly Val
  65                  70                  75                  80
 Ser His Cys Leu Val Ser Pro Thr Cys Arg Gly Ser Arg Trp Leu Leu
                  85                  90                  95    
 Leu Ala Gly Gln Thr Asp Arg Gln Leu Cys Ser Ser Leu Pro Cys Leu
             100                 105                 110        
 Ser Leu Ala Gly Val Glu Tyr
         115                



      <210> 951
      <211> 29
      <212> PRT
      <213> Homo sapiens


      <400> 951
 Met Arg Leu Gly Pro Gly Glu Asp Arg Glu Ala Ser Arg Ser Pro His
   1               5                  10                  15    
 Leu Arg Arg Pro Pro Leu Pro Ala Pro Ser Glu Cys Arg
              20                  25                



      <210> 952
      <211> 625
      <212> PRT
      <213> Homo sapiens


      <400> 952
 Met Asn Val Thr Ser Ile Ala Leu Arg Ala Glu Thr Trp Leu Leu Ala
   1               5                  10                  15    
 Ala Trp His Val Lys Val Pro Pro Met Trp Leu Glu Ala Cys Ile Asn
              20                  25                  30        
 Trp Ile Gln Glu Glu Asn Asn Asn Val Asn Leu Ser Gln Ala Gln Met
          35                  40                  45            
 Asn Lys Gln Val Phe Glu Gln Trp Leu Leu Thr Asp Leu Arg Asp Leu
      50                  55                  60                
 Glu His Pro Leu Leu Pro Asp Gly Ile Leu Glu Ile Pro Lys Gly Glu
  65                  70                  75                  80
 Leu Asn Gly Phe Tyr Ala Leu Gln Ile Asn Ser Leu Val Asp Val Ser
                  85                  90                  95    
 Gln Pro Ala Tyr Ser Gln Ile Gln Lys Leu Arg Gly Lys Asn Thr Thr
             100                 105                 110        
 Asn Asp Leu Val Thr Ala Glu Ala Gln Val Thr Pro Lys Pro Trp Glu
         115                 120                 125            
 Ala Lys Pro Ser Arg Met Leu Met Leu Gln Leu Thr Asp Gly Ile Val
     130                 135                 140                
 Gln Ile Gln Gly Met Glu Tyr Gln Pro Ile Pro Ile Leu His Ser Asp
 145                 150                 155                 160
 Leu Pro Pro Gly Thr Lys Ile Leu Ile Tyr Gly Asn Ile Ser Phe Arg
                 165                 170                 175    
 Leu Gly Val Leu Leu Leu Lys Pro Glu Asn Val Lys Val Leu Gly Gly
             180                 185                 190        
 Glu Val Asp Ala Leu Leu Glu Glu Tyr Ala Gln Glu Lys Val Leu Ala
         195                 200                 205            
 Arg Leu Ile Gly Glu Pro Asp Leu Val Val Ser Val Ile Pro Asn Asn
     210                 215                 220                
 Ser Asn Glu Asn Ile Pro Arg Val Thr Asp Val Leu Asp Pro Ala Leu
 225                 230                 235                 240
 Gly Pro Ser Asp Glu Glu Leu Leu Ala Ser Leu Asp Glu Asn Asp Glu
                 245                 250                 255    
 Leu Thr Ala Asn Asn Asp Thr Ser Ser Glu Arg Cys Phe Thr Thr Gly
             260                 265                 270        
 Ser Ser Ser Asn Thr Ile Pro Thr Arg Gln Ser Ser Phe Glu Pro Glu
         275                 280                 285            
 Phe Val Ile Ser Pro Arg Pro Lys Glu Glu Pro Ser Asn Leu Ser Ile
     290                 295                 300                
 His Val Met Asp Gly Glu Leu Asp Asp Phe Ser Leu Glu Glu Ala Leu
 305                 310                 315                 320
 Leu Leu Glu Glu Thr Val Gln Lys Glu Gln Met Glu Thr Lys Glu Leu
                 325                 330                 335    
 Gln Pro Leu Thr Phe Asn Arg Asn Ala Asp Arg Ser Ile Glu Arg Phe
             340                 345                 350        
 Ser His Asn Pro Asn Thr Thr Asn Asn Phe Ser Leu Thr Cys Lys Asn
         355                 360                 365            
 Gly Asn Asn Asn Trp Ser Glu Lys Asn Val Ser Glu Gln Met Thr Asn
     370                 375                 380                
 Glu Asp Lys Ser Phe Gly Cys Pro Ser Val Arg Asp Gln Asn Arg Ser
 385                 390                 395                 400
 Ile Phe Ser Val His Cys Asn Val Pro Leu Ala His Asp Phe Thr Asn
                 405                 410                 415    
 Lys Glu Lys Asn Leu Glu Thr Asp Asn Lys Ile Lys Gln Thr Ser Ser
             420                 425                 430        
 Ser Asp Ser His Ser Leu Asn Asn Lys Ile Leu Asn Arg Glu Val Val
         435                 440                 445            
 Asn Tyr Val Gln Lys Arg Ser Ser Gln Ile Ser Asn Glu Asn Asp Cys
     450                 455                 460                
 Asn Leu Gln Ser Cys Ser Leu Arg Ser Ser Glu Asn Ser Ile Asn Leu
 465                 470                 475                 480
 Ser Ile Ala Met Asp Leu Tyr Ser Pro Pro Phe Val Tyr Leu Ser Val
                 485                 490                 495    
 Leu Met Ala Ser Lys Pro Lys Glu Val Thr Thr Val Lys Val Lys Ala
             500                 505                 510        
 Phe Ile Val Thr Leu Thr Gly Asn Leu Ser Ser Ser Gly Gly Ile Trp
         515                 520                 525            
 Ser Ile Thr Ala Lys Val Ser Asp Gly Thr Ala Tyr Leu Asp Val Asp
     530                 535                 540                
 Phe Val Asp Glu Ile Leu Thr Ser Leu Ile Gly Phe Ser Val Pro Glu
 545                 550                 555                 560
 Met Lys Gln Ser Lys Lys Asp Pro Leu Gln Tyr Gln Lys Phe Leu Glu
                 565                 570                 575    
 Gly Leu Gln Lys Cys Gln Arg Asp Leu Ile Asp Leu Cys Cys Leu Met
             580                 585                 590        
 Thr Ile Ser Phe Asn Pro Ser Leu Ser Lys Ala Met Val Leu Ala Leu
         595                 600                 605            
 Gln Asp Val Asn Met Glu His Leu Glu Asn Leu Lys Lys Arg Leu Asn
     610                 615                 620                
 Lys
 625



      <210> 953
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 953
 Met Thr Ser Pro Leu Glu Lys Asp Pro Glu Pro Asn Gly Ala Leu Ser
   1               5                  10                  15    
 Pro Gly Pro Gly Asp Thr Asn Ser Trp Gly Phe Gly Arg Asp Pro Ala
              20                  25                  30        
 Pro Ser Pro Arg Asp Ser Leu Ala Pro Glu Asp Leu Glu Met Phe Val
          35                  40                  45            
 Leu Asp Phe Glu Asp Gly Asp Leu Trp Glu Ser Ile Arg Gly Gln Leu
      50                  55                  60                
 Gly Pro Met Ala Gly Pro Pro Thr Cys His Arg Leu Glu Asp Asn Pro
  65                  70                  75                  80
 Gly Val Arg Arg His Leu Val Lys Lys Pro Ser Arg Thr Gln Gly Gly
                  85                  90                  95    
 Arg Gly Thr Pro Ser Trp Pro Gly Pro His Pro Ser Gln Glu Glu Glu
             100                 105                 110        
 Glu Glu Lys Ala Gly Pro Glu Ala Ser
         115                 120    



      <210> 954
      <211> 47
      <212> PRT
      <213> Homo sapiens


      <400> 954
 Met Val Ser Leu Val Val Ala Ala Phe Tyr Lys Ile Ala Met Asp Glu
   1               5                  10                  15    
 Pro Arg Lys Lys Ala Tyr Ala Asp Phe Tyr Arg Asn Tyr Asp Ser Ile
              20                  25                  30        
 Lys Asp Phe Glu Met Arg Lys Ala Gly Ile Phe Gln Ser Thr Lys
          35                  40                  45        



      <210> 955
      <211> 70
      <212> PRT
      <213> Homo sapiens


      <400> 955
 Met Ile Leu Cys Phe Leu Leu Pro His His Arg Leu Gln Glu Ala Arg
   1               5                  10                  15    
 Gln Ile Gln Val Leu Lys Met Leu Pro Arg Glu Lys Leu Arg Arg Arg
              20                  25                  30        
 Glu Glu Arg Lys Gln Ile Asn Gly Lys Lys Glu Arg Thr Lys Tyr Glu
          35                  40                  45            
 Thr Pro Arg Lys Arg Glu Gly Lys Lys Gly Gly Asn Asn His Ile Cys
      50                  55                  60                
 His Leu Ser Lys Arg Asp
  65                  70



      <210> 956
      <211> 547
      <212> PRT
      <213> Homo sapiens


      <400> 956
 Met Ser Lys Arg Met Cys Ser Ala Phe Thr Leu Gln Asp Pro Val His
   1               5                  10                  15    
 Leu Val Pro Pro Pro Gly Ser Leu Leu Gln Ser Pro Pro Ser Phe Val
              20                  25                  30        
 Ile Cys Ser Glu Leu Ser Val Glu Glu Ala Gln Asp Pro Phe Leu Val
          35                  40                  45            
 Ser Ile His Ile Ile Ala Asp Pro Gly Glu Ser Gln Pro Leu Gln Glu
      50                  55                  60                
 Ala Ile Asp Asn Val Leu Ala Trp Ile His Pro Asp Leu Pro Leu Phe
  65                  70                  75                  80
 Arg Val Ser Glu Arg Arg Ala Ser Arg Arg Arg Arg Lys Pro Pro Lys
                  85                  90                  95    
 Gly Ala Gln Pro Ala Leu Ala Val Val Leu Phe Leu Gln Glu Glu Tyr
             100                 105                 110        
 Gly Glu Glu Gln Ile Leu Gln Leu His Arg Thr Leu Gln Gln Pro Pro
         115                 120                 125            
 Trp Arg His His His Thr Glu Gln Val His Gly Arg Phe Leu Pro Tyr
     130                 135                 140                
 Leu Pro Cys Ser Gln Asp Phe Phe Thr Leu Ala Pro Gly Thr Pro Leu
 145                 150                 155                 160
 Trp Ala Ile Arg Pro Val His Tyr Gly Lys Glu Ile Val Arg Phe Thr
                 165                 170                 175    
 Val Tyr Cys Arg Tyr Asp Asn Tyr Ala Asp Ser Leu Arg Phe Tyr Gln
             180                 185                 190        
 Leu Ile Leu Arg Arg Ser Pro Ser Gln Lys Lys Ala Asp Phe Cys Ile
         195                 200                 205            
 Phe Pro Ile Phe Ser Asn Leu Asp Val Asp Ile Gln Phe Ser Leu Lys
     210                 215                 220                
 Arg Leu Pro Cys Asp Gln Cys Pro Val Pro Thr Asp Ser Ser Val Leu
 225                 230                 235                 240
 Glu Phe Arg Val Arg Asp Ile Gly Glu Leu Val Pro Leu Leu Pro Asn
                 245                 250                 255    
 Pro Cys Ser Pro Ile Ser Glu Gly Arg Trp Gln Thr Glu Asp His Asp
             260                 265                 270        
 Gly Asn Lys Ile Leu Leu Gln Ala Gln Arg Val His Lys Lys Phe Pro
         275                 280                 285            
 Lys Pro Gly Arg Val His His Ala Ser Glu Lys Lys Arg His Ser Thr
     290                 295                 300                
 Pro Leu Pro Ser Thr Ala Val Pro Ser His Thr Pro Gly Ser Ser Gln
 305                 310                 315                 320
 Gln Ser Pro Leu Asn Ser Pro His Pro Gly Pro Ile Arg Thr Gly Leu
                 325                 330                 335    
 Pro Pro Gly His Gln Gln Glu Phe Ala Gly Arg Ala Asn Ser Thr Pro
             340                 345                 350        
 Asn Pro Pro Trp Ser Phe Gln Arg Ser Lys Ser Leu Phe Cys Leu Pro
         355                 360                 365            
 Thr Gly Gly Pro Ser Leu Ala Ser Ser Ala Glu Pro Gln Trp Phe Ser
     370                 375                 380                
 Asn Thr Gly Ala Pro Gly His Arg Ala Ser Glu Trp Arg His Gly His
 385                 390                 395                 400
 Leu Leu Ser Ile Asp Asp Leu Glu Gly Ala Gln Glu Thr Asp Val Asp
                 405                 410                 415    
 Thr Gly Leu Arg Leu Ser Ser Ser Asp Leu Ser Val Val Ser Ala Tyr
             420                 425                 430        
 Ser Ala Pro Ser Arg Phe Cys Ser Thr Val Glu Thr Pro Leu Pro Ser
         435                 440                 445            
 Glu Arg Cys Ser Ser His Trp Ala Ala His Lys Asp Ser Arg Glu Gly
     450                 455                 460                
 Pro Leu Pro Thr Val Ser Arg Val Thr Thr Glu Ala Ser Trp Ala Ser
 465                 470                 475                 480
 Leu Pro Phe Phe Thr Lys Arg Ser Ser Ser Ser Ser Ala Thr Ala Arg
                 485                 490                 495    
 Ala Ala Pro Pro Ala Pro Ser Thr Ser Thr Leu Thr Asp Ser Ser Pro
             500                 505                 510        
 Gln Leu Pro Cys Asp Thr Pro Lys Val Lys Gln Thr Asp Gly Asp Met
         515                 520                 525            
 Pro Pro Pro Pro Gly Ser Ala Gly Pro Gly Asp Asn Asp Met Glu Glu
     530                 535                 540                
 Phe Tyr Ile
 545        



      <210> 957
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 957
 Met Ala Glu His Pro Pro Leu Leu Asp Thr Thr Gln Ile Leu Ser Ser
   1               5                  10                  15    
 Asp Ile Ser Leu Leu Ser Ala Pro Ile Val Ser Ala Asp Gly Thr Gln
              20                  25                  30        
 Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Ala Phe Thr Ile Arg
          35                  40                  45            
 Arg Glu Asp Gly Gln Phe Gln Cys Ile Thr Gly Pro Ala Gln Val Pro
      50                  55                  60                
 Met Met Ser Pro Asn Gly Ser Val Pro Pro Ile Tyr Val Pro Pro Gly
  65                  70                  75                  80
 Tyr Ala Pro Gln Val Ile Glu Asp Asn Gly Val Arg Arg Val Val Val
                  85                  90                  95    
 Val Pro Gln Ala Pro Glu Phe His Pro Gly Ser His Thr Val Leu His
             100                 105                 110        
 Arg Ser Pro His Pro Pro Leu Pro Gly Phe Ile Pro Val Pro Thr Met
         115                 120                 125            
 Met Pro Pro Pro Pro Arg His Met Tyr Ser Pro Val Thr Gly Ala Gly
     130                 135                 140                
 Asp Met Thr Thr Gln Tyr Met Pro Gln Tyr Gln Ser Ser Gln Val Tyr
 145                 150                 155                 160
 Gly Asp Val Asp Ala His Ser Thr His Gly Arg Ser Asn Phe Arg Asp
                 165                 170                 175    
 Glu Arg Ser Ser Lys Thr Tyr Glu Arg Leu Gln Lys Lys Leu Lys Asp
             180                 185                 190        
 Arg Gln Gly Thr Gln Lys Asp Lys Met Ser Ser Pro Pro Ser Ser Pro
         195                 200                 205            
 Gln Lys Cys Pro Ser Pro Ile Asn Glu His Asn Gly Leu Ile Lys Gly
     210                 215                 220                
 Gln Ile Ala Gly Gly
 225                



      <210> 958
      <211> 144
      <212> PRT
      <213> Homo sapiens


      <400> 958
 Met Leu Lys Arg Lys Gln Ser Ser Arg Val Glu Ala Gln Pro Val Thr
   1               5                  10                  15    
 Asp Phe Gly Pro Asp Glu Ser Leu Ser Asp Asn Ala Asp Ile Leu Trp
              20                  25                  30        
 Ile Asn Lys Pro Trp Val His Ser Leu Leu Arg Ile Cys Ala Ile Ile
          35                  40                  45            
 Ser Val Ile Ser Val Cys Met Asn Thr Pro Met Thr Phe Glu His Tyr
      50                  55                  60                
 Pro Pro Leu Gln Tyr Val Thr Phe Thr Leu Asp Thr Leu Leu Met Phe
  65                  70                  75                  80
 Leu Tyr Thr Ala Glu Met Ile Ala Lys Met His Ile Arg Gly Ile Val
                  85                  90                  95    
 Lys Val Phe Glu Ile Ala Asp Ile Val Asp Gln Met Ser Pro Trp Gly
             100                 105                 110        
 Met Leu Arg Ile Pro Arg Pro Leu Ile Met Ile Arg Ala Phe Arg Ile
         115                 120                 125            
 Tyr Phe Arg Phe Glu Leu Pro Arg Thr Arg Ile Thr Asn Ile Leu Lys
     130                 135                 140                





      <210> 959
      <211> 177
      <212> PRT
      <213> Homo sapiens


      <400> 959
 Met Cys Ser Asn Ser Ile Val Lys Pro Trp Ala Ala Arg Cys Leu Arg
   1               5                  10                  15    
 Trp Tyr Ser Ser Asp Pro Ser Ile Asp Thr Gly Arg Val Met Glu Arg
              20                  25                  30        
 Asp Thr Ser Ile Thr Thr Thr Val Gly Met Met Lys Met Ile Pro Val
          35                  40                  45            
 Phe Pro Ile Arg Met Gln Thr Asp Ser Tyr Lys Arg Arg Asn Ala Ala
      50                  55                  60                
 Leu Trp Leu Ser Arg Gln Pro Pro Gly Val Pro Pro Gln Phe Ser Asp
  65                  70                  75                  80
 Ile Ile Ser Ser Leu Lys Val Gln Thr Glu Asn His Ile Trp Glu Met
                  85                  90                  95    
 Tyr Phe Tyr Leu Lys Asn Gln Ser Arg Lys Cys Gly Ile Trp Lys Ser
             100                 105                 110        
 Leu Leu Glu Arg Gly Gly Arg Gly Glu Leu Ser Arg Gly Arg Asn Arg
         115                 120                 125            
 Ala Val Tyr Ala Glu Leu Gly Thr Pro Ser Leu Arg Ala Arg Gly Gly
     130                 135                 140                
 Arg Glu Gln Arg Pro Gly Thr Gly Ala Ser Gln Thr Ala Arg Gly Gly
 145                 150                 155                 160
 Arg His Gly Gly Gly Lys Ala Lys Arg Trp Pro Trp Val Val Leu His
                 165                 170                 175    
 Pro
    



      <210> 960
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 960
 Met Thr Asp Thr Ala Glu Ala Val Pro Lys Phe Glu Glu Met Phe Ala
   1               5                  10                  15    
 Ser Arg Phe Thr Glu Asn Asp Lys Glu Tyr Gln Glu Tyr Leu Lys Arg
              20                  25                  30        
 Pro Pro Glu Ser Pro Pro Ile Val Glu Glu Trp Asn Ser Arg Ala Gly
          35                  40                  45            
 Gly Asn Gln Arg Asn Arg Gly Asn Arg Leu Gln Asp Asn Arg Gln Phe
      50                  55                  60                
 Arg Gly Arg Asp Asn Arg Trp Gly Trp Pro Ser Asp Asn Arg Ser Asn
  65                  70                  75                  80
 Gln Trp His Gly Arg Ser Trp Gly Asn Asn Tyr Pro Gln His Arg Gln
                  85                  90                  95    
 Glu Pro Tyr Tyr Pro Gln Gln Tyr Gly His Tyr Gly Tyr Asn Gln Arg
             100                 105                 110        
 Pro Pro Tyr Gly Tyr Tyr
         115            



      <210> 961
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 961
 Met Trp Gly Pro Cys Ser Leu Ser Val Gln His Leu Trp Leu Trp Gln
   1               5                  10                  15    
 Thr Trp Ser Asp Val Glu Gly Gln Arg Pro Ala Leu Leu Ile Cys Thr
              20                  25                  30        
 Ala Ala Ala Gly Pro Thr Gln Gly Val Lys Gly Tyr Gly Lys Pro Phe
          35                  40                  45            
 Glu Pro Arg Ser Val Lys Asn Ile His Ser Thr Pro Ala Tyr Pro Asp
      50                  55                  60                
 Ala Thr Met His Arg Gln Leu Leu Ala Pro Val Glu Gly Arg Met Ala
  65                  70                  75                  80
 Glu Thr Leu Asn Gln Lys Leu His Val Ala Asn Val Leu Glu Asp Asp
                  85                  90                  95    
 Pro Gly Tyr Leu Pro His Val Tyr Ser Glu Glu Gly Glu Cys Gly Gly
             100                 105                 110        
 Ala Pro Ser Leu Ser Ser Leu Ala Ser Leu Glu Gln Glu Leu Gln Pro
         115                 120                 125            
 Asp Leu Leu Asp Ser Leu Gly Ser Lys Ala Thr Pro Phe Glu Glu Ile
     130                 135                 140                
 Tyr Ser Glu Ser Gly Val Pro Ser
 145                 150        



      <210> 962
      <211> 323
      <212> PRT
      <213> Homo sapiens


      <400> 962
 Met Leu Phe Leu Ser Asp Ile Asn Asp Asn Val Pro Thr Leu Arg Pro
   1               5                  10                  15    
 Arg Ser Arg Tyr Met Glu Val Cys Glu Ser Ala Val His Glu Pro Leu
              20                  25                  30        
 His Ile Glu Ala Glu Asp Pro Asp Leu Glu Pro Phe Ser Asp Pro Phe
          35                  40                  45            
 Thr Phe Glu Leu Asp Asn Thr Trp Gly Asn Ala Glu Asp Thr Trp Lys
      50                  55                  60                
 Leu Gly Arg Asn Trp Gly Gln Ser Val Glu Leu Leu Thr Leu Arg Ser
  65                  70                  75                  80
 Leu Pro Arg Gly Asn Tyr Leu Val Pro Leu Phe Ile Gly Asp Lys Gln
                  85                  90                  95    
 Gly Leu Ser Gln Lys Gln Thr Val His Val Arg Ile Cys Pro Cys Ala
             100                 105                 110        
 Ser Gly Leu Thr Cys Val Glu Leu Ala Asp Ala Glu Val Gly Leu His
         115                 120                 125            
 Val Gly Ala Leu Phe Pro Val Cys Ala Ala Phe Val Ala Leu Ala Val
     130                 135                 140                
 Ala Leu Leu Phe Leu Leu Arg Cys Tyr Phe Val Leu Glu Pro Lys Arg
 145                 150                 155                 160
 His Gly Cys Ser Val Ser Asn Asp Glu Gly His Gln Thr Leu Val Met
                 165                 170                 175    
 Tyr Asn Ala Glu Ser Lys Gly Thr Ser Ala Gln Thr Trp Ser Asp Val
             180                 185                 190        
 Glu Gly Gln Arg Pro Ala Leu Leu Ile Cys Thr Ala Ala Ala Gly Pro
         195                 200                 205            
 Thr Gln Gly Val Lys Gly Tyr Gly Lys Pro Phe Glu Pro Arg Ser Val
     210                 215                 220                
 Lys Asn Ile His Ser Thr Pro Ala Tyr Pro Asp Ala Thr Met His Arg
 225                 230                 235                 240
 Gln Leu Leu Ala Pro Val Glu Gly Arg Met Ala Glu Thr Leu Asn Gln
                 245                 250                 255    
 Lys Leu His Val Ala Asn Val Leu Glu Asp Asp Pro Gly Tyr Leu Pro
             260                 265                 270        
 His Val Tyr Ser Glu Glu Gly Glu Cys Gly Gly Ala Pro Ser Leu Ser
         275                 280                 285            
 Ser Leu Ala Ser Leu Glu Gln Glu Leu Gln Pro Asp Leu Leu Asp Ser
     290                 295                 300                
 Leu Gly Ser Lys Ala Thr Pro Phe Glu Glu Ile Tyr Ser Glu Ser Gly
 305                 310                 315                 320
 Val Pro Ser
            



      <210> 963
      <211> 305
      <212> PRT
      <213> Homo sapiens


      <400> 963
 Met Leu Phe Leu Ser Asp Ile Asn Asp Asn Val Pro Thr Leu Arg Pro
   1               5                  10                  15    
 Arg Ser Arg Tyr Met Glu Val Cys Glu Ser Ala Val His Glu Pro Leu
              20                  25                  30        
 His Ile Glu Ala Glu Asp Pro Asp Leu Glu Pro Phe Ser Asp Pro Phe
          35                  40                  45            
 Thr Phe Glu Leu Asp Asn Thr Trp Gly Asn Ala Glu Asp Thr Trp Lys
      50                  55                  60                
 Leu Gly Arg Asn Trp Gly Gln Ser Val Glu Leu Leu Thr Leu Arg Ser
  65                  70                  75                  80
 Leu Pro Arg Gly Asn Tyr Leu Val Pro Leu Phe Ile Gly Asp Lys Gln
                  85                  90                  95    
 Gly Leu Ser Gln Lys Gln Thr Val His Val Arg Ile Cys Pro Cys Ala
             100                 105                 110        
 Ser Gly Leu Thr Cys Val Glu Leu Ala Asp Ala Glu Val Gly Leu His
         115                 120                 125            
 Val Gly Ala Leu Phe Pro Val Cys Ala Ala Phe Val Ala Leu Ala Val
     130                 135                 140                
 Ala Leu Leu Phe Leu Leu Arg Cys Tyr Phe Val Leu Glu Pro Lys Arg
 145                 150                 155                 160
 His Gly Cys Ser Val Ser Asn Asp Glu Gly His Gln Thr Leu Val Met
                 165                 170                 175    
 Tyr Asn Ala Glu Ser Lys Gly Thr Ser Ala Gln Thr Trp Ser Asp Val
             180                 185                 190        
 Glu Gly Gln Arg Pro Ala Leu Leu Ile Cys Thr Ala Ala Ala Gly Pro
         195                 200                 205            
 Thr Gln Gly Val Lys Ala Tyr Pro Asp Ala Thr Met His Arg Gln Leu
     210                 215                 220                
 Leu Ala Pro Val Glu Gly Arg Met Ala Glu Thr Leu Asn Gln Lys Leu
 225                 230                 235                 240
 His Val Ala Asn Val Leu Glu Asp Asp Pro Gly Tyr Leu Pro His Val
                 245                 250                 255    
 Tyr Ser Glu Glu Gly Glu Cys Gly Gly Ala Pro Ser Leu Ser Ser Leu
             260                 265                 270        
 Ala Ser Leu Glu Gln Glu Leu Gln Pro Asp Leu Leu Asp Ser Leu Gly
         275                 280                 285            
 Ser Lys Ala Thr Pro Phe Glu Glu Ile Tyr Ser Glu Ser Gly Val Pro
     290                 295                 300                
 Ser
 305



      <210> 964
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 964
 Met Cys Ser Asn Ser Ile Val Lys Pro Trp Ala Ala Arg Cys Leu Arg
   1               5                  10                  15    
 Trp Tyr Ser Ser Asp Pro Ser Ile Asp Thr Gly Arg Val Met Glu Arg
              20                  25                  30        
 Asp Thr Ser Ile Thr Thr Thr Val Gly Met Met Lys Met Ile Pro Val
          35                  40                  45            
 Phe Pro Ile Arg Met Gln Thr Asp Ser Leu Lys Ile Ser Gln Glu Asn
      50                  55                  60                
 Val Gly Ser Gly Ser Leu Ser Trp Lys Glu Gly Ala Glu Gly Ser
  65                  70                  75                



      <210> 965
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 965
 Met Glu Leu Trp Ala Pro Gln Arg Leu Pro Gln Thr Arg Gly Lys Ala
   1               5                  10                  15    
 Thr Ala Pro Ser Lys Asp Pro Asp Arg Gly Phe Arg Arg Asp Gly His
              20                  25                  30        
 His Arg Pro Val Pro His Ser Trp His Asn Gly Glu Arg Phe His Gln
          35                  40                  45            
 Trp Gln Asp Asn Arg Gly Ser Pro Gln Pro Gln Gln Glu Pro Arg Ala
      50                  55                  60                
 Asp His Gln Gln Gln Pro His Tyr Ala Ser Arg Pro Gly Asp Trp His
  65                  70                  75                  80
 Gln Pro Val Ser Gly Val Asp Tyr Tyr Glu Gly Gly Tyr Arg Asn Gln
                  85                  90                  95    
 Leu Tyr Ser Arg Pro Gly Tyr Glu Asn Ser Tyr Gln Ser Tyr Gln Ser
             100                 105                 110        
 Pro Thr Met Arg Glu Glu Tyr Ala Tyr Gly Ser Tyr Tyr Tyr His Gly
         115                 120                 125            
 His Pro Gln Leu Ala Ala Gly Gln Lys Glu Cys Gln Gly Asn Gly Val
     130                 135                 140                
 Leu Ile Ser Gly Thr Lys Ile Thr Glu Ser Lys Ser Thr Leu Met Asn
 145                 150                 155                 160
 Ile Ile Met Lys Thr Ser Thr Val His Trp Asn Asn Ser Glu Thr His
                 165                 170                 175    
 Phe Gln Ser Asn Ser Arg Glu Pro Leu
             180                 185



      <210> 966
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 966
 Met Glu Val Ala Ala Asn Cys Ser Leu Arg Val Lys Arg Pro Leu Leu
   1               5                  10                  15    
 Asp Pro Arg Phe Glu Gly Tyr Lys Leu Ser Leu Glu Pro Leu Pro Cys
              20                  25                  30        
 Tyr Gln Leu Glu Leu Asp Ala Ala Val Ala Glu Val Lys Leu Arg Asp
          35                  40                  45            
 Asp Gln Tyr Thr Leu Glu His Met His Ala Phe Gly Met Tyr Asn Tyr
      50                  55                  60                
 Leu His Cys Asp Ser Trp Tyr Gln Asp Ser Val Tyr Tyr Ile Asp Thr
  65                  70                  75                  80
 Leu Gly Arg Ile Met Asn Leu Thr Val Met Leu Asp Thr Ala Leu Gly
                  85                  90                  95    
 Lys Pro Arg Glu Val Phe Arg Leu Pro Thr Asp Leu Thr Ala Cys Asp
             100                 105                 110        
 Asn Arg Leu Cys Ala Ser Ile His Phe Ser Ser Ser Thr Trp Val Thr
         115                 120                 125            
 Leu Ser Asp Gly Thr Gly Arg Leu Tyr Val Ile Gly Thr Gly Glu Arg
     130                 135                 140                
 Gly Asn Ser Ala Ser Glu Lys Trp Glu Ile Met Phe Thr Glu Glu Leu
 145                 150                 155                 160
 Gly Asp Pro Phe Ile Ile Ile His Ser Ile Ser Leu Pro Lys Cys
                 165                 170                 175



      <210> 967
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 967
 Met Leu Phe Ile Asn His Ile Phe Gln Met Arg Glu Trp Glu Phe Ile
   1               5                  10                  15    
 Gly Leu Arg Ser Asp Ala Ile Pro Gln Thr Pro Ala Leu Met Pro Val
              20                  25                  30        
 Ser Cys Cys His Pro His Pro Leu Leu Phe Gln Ser Arg Pro Gly Ala
          35                  40                  45            
 Leu His Pro Cys Phe Cys Gly Pro Leu Cys Leu Leu Gln Ser Gln Tyr
      50                  55                  60                





      <210> 968
      <211> 541
      <212> PRT
      <213> Homo sapiens


      <400> 968
 Met Pro Gly Phe Ile Gln Lys Gln Gln Ala Arg Val Tyr Val Gln Phe
   1               5                  10                  15    
 Phe Leu Ala Asp Ala Leu Ile Leu Pro Val Pro Arg Pro Cys Leu His
              20                  25                  30        
 Ser Ala Thr Pro Ser Thr Pro Gln Thr Asp Pro Thr Gly Pro Glu Gly
          35                  40                  45            
 Pro His Leu Gly Gln Ser Arg Leu Phe Leu Leu Cys His Lys Glu Ala
      50                  55                  60                
 Leu Met Lys Arg Asn Phe Cys Val Pro Pro Gly Ala Ser Pro Glu Val
  65                  70                  75                  80
 Pro Lys Pro Ala Leu Ser Phe Tyr Val Leu Gly Ser Trp Leu Gly Gly
                  85                  90                  95    
 Thr Gln Arg Lys Glu Gly Thr Gly Trp Gly Leu Pro Glu Pro Gln Gly
             100                 105                 110        
 Asn Asp Asp Asn Asp Gln Lys Val His Leu Ile Phe Phe Gly Ser Ser
         115                 120                 125            
 Val Arg Trp Phe Glu Phe Leu His Pro Gly Gln Val Tyr Arg Leu Val
     130                 135                 140                
 Ala Pro Gly Pro Ala Thr Pro Met Leu Phe Glu Lys Asp Gly Ser Ser
 145                 150                 155                 160
 Cys Ile Ser Arg Arg Pro Leu Glu Leu Ala Gly Cys Ala Ser Cys Leu
                 165                 170                 175    
 Thr Val Gln Asp Asn Trp Thr Leu Glu Leu Glu Ser Ser Gln Asp Ile
             180                 185                 190        
 Gln Asp Val Leu Asp Ala Asn Lys Ser Leu Pro Glu Ser Ser Leu Thr
         195                 200                 205            
 Asp Leu Leu Ser Asp Asn Phe Thr Asp Ser Leu Val Ser Phe Ser Ala
     210                 215                 220                
 Glu Ile Leu Ser Arg Thr Leu Cys Glu Pro Leu Val Ala Ser Leu Trp
 225                 230                 235                 240
 Met Lys Leu Gly Asn Thr Gly Ala Met Arg Arg Cys Val Lys Leu Thr
                 245                 250                 255    
 Val Ala Leu Glu Thr Ala Glu Cys Glu Phe Pro Pro His Leu Asp Val
             260                 265                 270        
 Tyr Ile Glu Asp Pro His Leu Pro Pro Ser Leu Gly Leu Leu Pro Gly
         275                 280                 285            
 Ala Arg Val His Phe Ser Gln Leu Glu Lys Arg Val Ser Arg Ser His
     290                 295                 300                
 Asn Val Tyr Cys Cys Phe Arg Ser Ser Thr Tyr Val Gln Val Leu Ser
 305                 310                 315                 320
 Phe Pro Pro Glu Thr Thr Ile Ser Val Pro Leu Pro His Ile Tyr Leu
                 325                 330                 335    
 Ala Glu Leu Leu Gln Gly Gly Gln Ser Pro Phe Gln Ala Thr Ala Ser
             340                 345                 350        
 Cys His Ile Val Ser Val Phe Ser Leu Gln Leu Phe Trp Val Cys Ala
         355                 360                 365            
 Tyr Cys Thr Ser Ile Cys Arg Gln Gly Lys Cys Thr Arg Leu Gly Ser
     370                 375                 380                
 Thr Cys Pro Thr Gln Thr Ala Ile Ser Gln Ala Ile Ile Arg Leu Leu
 385                 390                 395                 400
 Val Glu Asp Gly Thr Ala Glu Ala Val Val Thr Cys Arg Asn His His
                 405                 410                 415    
 Val Ala Ala Ala Leu Gly Leu Cys Pro Arg Glu Trp Ala Ser Leu Leu
             420                 425                 430        
 Asp Phe Val Gln Val Pro Gly Arg Val Val Leu Gln Phe Ala Gly Pro
         435                 440                 445            
 Gly Ala Gln Leu Glu Ser Ser Ala Arg Val Asp Glu Pro Met Thr Met
     450                 455                 460                
 Phe Leu Trp Thr Leu Cys Thr Ser Pro Ser Val Leu Arg Pro Ile Val
 465                 470                 475                 480
 Leu Ser Phe Glu Leu Glu Arg Lys Pro Ser Lys Ile Val Pro Leu Glu
                 485                 490                 495    
 Pro Pro Arg Leu Gln Arg Phe Gln Cys Gly Glu Leu Pro Phe Leu Thr
             500                 505                 510        
 His Val Asn Pro Arg Leu Arg Leu Ser Cys Leu Ser Ile Arg Glu Ser
         515                 520                 525            
 Glu Tyr Ser Ser Ser Leu Gly Ile Leu Ala Ser Ser Cys
     530                 535                 540    



      <210> 969
      <211> 54
      <212> PRT
      <213> Homo sapiens


      <400> 969
 Met Glu Ile Asn Asn Asn Arg Ile Phe Gly Met Ala Leu Leu Ala Asn
   1               5                  10                  15    
 Pro Lys Pro Ser Gly Leu Lys Trp Gly Val Phe Thr Ser Gly Thr Ser
              20                  25                  30        
 Ser Leu Gly Thr Phe His Leu Ser Ile Pro Arg His Arg Gln Glu Gly
          35                  40                  45            
 Asp Ile Thr Pro Phe Thr
      50                



      <210> 970
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 970
 Met Val His Phe Ala Asn Pro Glu Asp Gln Phe Leu Gly Phe Gln Ala
   1               5                  10                  15    
 Ser Ala Phe Leu Leu His Val Leu Lys Pro Pro His Gly Ala Ala Thr
              20                  25                  30        
 Pro Ser Gly Ser Ser Gln Gly Gly Pro Ala Met Phe Ser Gly Leu Pro
          35                  40                  45            
 Val Ser Pro Leu Pro Ser Ser Tyr Pro Gln Asn Pro Ser Phe Ile Pro
      50                  55                  60                
 Pro Pro Ser Ser Cys Val Ser Cys Ser Thr His Thr Gly Glu Ala Leu
  65                  70                  75                  80
 His Ser Ser Ser Ile Phe Gln Pro Trp His Arg Thr Asp Gly Lys Gly
                  85                  90                  95    
 Arg Ala Gly Phe Ser Ala Ser Gly Thr Arg Gly Arg Pro His Leu Thr
             100                 105                 110        
 Pro Pro Ser Pro Val His Gln Thr Gly
         115                 120    



      <210> 971
      <211> 158
      <212> PRT
      <213> Homo sapiens


      <400> 971
 Met Arg Ala Ser Arg Ser Pro Pro Ser Pro Arg Arg Cys His His His
   1               5                  10                  15    
 His Glu Ala Thr Gly Ala Ala Ser Gly Ala Ala Ala Gly Gly Pro Gly
              20                  25                  30        
 Ala Gly Cys Val Gly Leu Cys Arg Leu Ala Leu Thr Pro Ser Ala Gln
          35                  40                  45            
 Asp Gly Arg Asn Ser Thr Phe Gln Thr Tyr Lys Lys Glu Val Cys Leu
      50                  55                  60                
 Pro Arg His Ser Met His Pro Gly Pro Trp Ala Ile Cys Cys Glu Cys
  65                  70                  75                  80
 Gln Thr Arg Phe Gly Gly Arg Leu Pro Val Ser Arg Val Glu Ala Ala
                  85                  90                  95    
 Leu Pro Tyr Trp Val Pro Leu Ser Leu Arg Pro Arg Lys Gln His Pro
             100                 105                 110        
 Cys Trp Met His Ala Ala Gly Thr Thr Ala Gly Gly Ser Ala Val Met
         115                 120                 125            
 Ser Ala Cys Cys Pro Ser Ser Ser Ser Ser Arg Pro Pro Thr Arg Thr
     130                 135                 140                
 Ser Tyr Arg Leu Leu Gln Arg Val Cys Cys Pro Ser Ala Ser
 145                 150                 155            



      <210> 972
      <211> 299
      <212> PRT
      <213> Homo sapiens


      <400> 972
 Met Glu Glu Leu Glu Gln Gly Leu Leu Met Gln Pro Trp Ala Trp Leu
   1               5                  10                  15    
 Gln Leu Ala Glu Asn Ser Leu Leu Ala Lys Val Phe Ile Thr Lys Gln
              20                  25                  30        
 Gly Tyr Ala Leu Leu Val Ser Asp Leu Gln Gln Val Trp His Glu Gln
          35                  40                  45            
 Val Asp Thr Ser Val Val Ser Gln Arg Ala Lys Glu Leu Asn Lys Arg
      50                  55                  60                
 Leu Thr Ala Pro Pro Ala Ala Phe Leu Cys His Leu Asp Asn Leu Leu
  65                  70                  75                  80
 Arg Pro Leu Leu Lys Asp Ala Ala His Pro Ser Glu Ala Thr Phe Ser
                  85                  90                  95    
 Cys Asp Cys Val Ala Asp Ala Leu Ile Leu Arg Val Arg Ser Glu Leu
             100                 105                 110        
 Ser Gly Leu Pro Phe Tyr Trp Asn Phe His Cys Met Leu Ala Ser Pro
         115                 120                 125            
 Ser Leu Val Ser Gln His Leu Ile Arg Pro Leu Met Gly Met Ser Leu
     130                 135                 140                
 Ala Leu Gln Cys Gln Val Arg Glu Leu Ala Thr Leu Leu His Met Lys
 145                 150                 155                 160
 Asp Leu Glu Ile Gln Asp Tyr Gln Glu Ser Gly Ala Thr Leu Ile Arg
                 165                 170                 175    
 Asp Arg Leu Lys Thr Glu Pro Phe Glu Glu Asn Ser Phe Leu Glu Gln
             180                 185                 190        
 Phe Met Ile Glu Lys Leu Pro Glu Ala Cys Ser Ile Gly Asp Gly Lys
         195                 200                 205            
 Pro Phe Val Met Asn Leu Gln Asp Leu Tyr Met Ala Val Thr Thr Gln
     210                 215                 220                
 Glu Val Gln Val Gly Gln Lys His Gln Gly Ala Gly Asp Pro His Thr
 225                 230                 235                 240
 Ser Asn Ser Ala Ser Leu Gln Gly Ile Asp Ser Gln Cys Val Asn Gln
                 245                 250                 255    
 Pro Glu Gln Leu Val Ser Ser Ala Pro Thr Leu Ser Ala Pro Glu Lys
             260                 265                 270        
 Glu Ser Thr Gly Thr Ser Gly Pro Leu Gln Arg Pro Gln Leu Ser Lys
         275                 280                 285            
 Val Lys Arg Lys Lys Pro Arg Gly Leu Phe Ser
     290                 295                



      <210> 973
      <211> 281
      <212> PRT
      <213> Homo sapiens


      <400> 973
 Met Glu Glu Leu Glu Gln Gly Leu Leu Met Gln Pro Trp Ala Trp Leu
   1               5                  10                  15    
 Gln Leu Ala Glu Asn Ser Leu Leu Ala Lys Val Phe Ile Thr Lys Gln
              20                  25                  30        
 Gly Tyr Ala Leu Leu Val Ser Asp Leu Gln Gln Val Trp His Glu Gln
          35                  40                  45            
 Val Asp Thr Ser Val Val Ser Gln Arg Ala Lys Glu Leu Asn Lys Arg
      50                  55                  60                
 Leu Thr Ala Pro Pro Ala Ala Phe Leu Cys His Leu Asp Asn Leu Leu
  65                  70                  75                  80
 Arg Pro Leu Leu Lys Asp Ala Ala His Pro Ser Glu Ala Thr Phe Ser
                  85                  90                  95    
 Cys Asp Cys Val Ala Asp Ala Leu Ile Leu Arg Val Arg Ser Glu Leu
             100                 105                 110        
 Ser Gly Leu Pro Phe Tyr Trp Asn Phe His Cys Met Leu Ala Ser Pro
         115                 120                 125            
 Ser Leu Val Ser Gln His Leu Ile Arg Pro Leu Met Gly Met Ser Leu
     130                 135                 140                
 Ala Leu Gln Cys Gln Val Arg Glu Leu Ala Thr Leu Leu His Met Lys
 145                 150                 155                 160
 Asp Leu Glu Ile Gln Asp Tyr Gln Glu Ser Gly Ala Thr Leu Ile Arg
                 165                 170                 175    
 Asp Arg Leu Lys Thr Glu Pro Phe Glu Val Gly Asp Gly Lys Pro Phe
             180                 185                 190        
 Val Met Asn Leu Gln Asp Leu Tyr Met Ala Val Thr Thr Gln Glu Val
         195                 200                 205            
 Gln Val Gly Gln Lys His Gln Gly Ala Gly Asp Pro His Thr Ser Asn
     210                 215                 220                
 Ser Ala Ser Leu Gln Gly Ile Asp Ser Gln Cys Val Asn Gln Pro Glu
 225                 230                 235                 240
 Gln Leu Val Ser Ser Ala Pro Thr Leu Ser Ala Pro Glu Lys Glu Ser
                 245                 250                 255    
 Thr Gly Thr Ser Gly Pro Leu Gln Arg Pro Gln Leu Ser Lys Val Lys
             260                 265                 270        
 Arg Lys Lys Pro Arg Gly Leu Phe Ser
         275                 280    



      <210> 974
      <211> 80
      <212> PRT
      <213> Homo sapiens


      <400> 974
 Met Gln Met Lys Thr Ile Gln Asp Lys Arg His Gly Ser Glu Ile His
   1               5                  10                  15    
 Thr His Ser Gly Phe His Thr Met Gly Leu Asn Ile Ser Pro Trp Cys
              20                  25                  30        
 Phe Leu Ala Ile Leu Thr Cys Ala Ile Ser Ala Ala Phe Ile Ser Val
          35                  40                  45            
 Gly Val Val Cys Trp Leu Leu Phe Leu Ile Ser His Arg Ser Ser Lys
      50                  55                  60                
 Asn Leu Arg Lys Ser Arg Val Arg Gly Val Trp Glu Asn Glu Glu Ile
  65                  70                  75                  80





      <210> 975
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 975
 Met Ser Leu Cys Ser Ala Cys Thr Ser Pro Ala Ser His Gln Leu Leu
   1               5                  10                  15    
 Leu Asn Cys Gln Gly Gln Thr Val Ala Lys Ser His Ser Ser Ala Asp
              20                  25                  30        
 Ala Gly Val Ser Leu Val Ser Gly Arg Trp Cys Ala Trp Trp Pro Glu
          35                  40                  45            
 His Cys Ser Glu Ser Met Phe Pro Ser Gln His Pro Val Leu Ser Ser
      50                  55                  60                
 Asn Leu Ala Asp Ser Ser Gly Gln Gly Arg Ser Pro Ala Gly Ala His
  65                  70                  75                  80
 Pro Ala Leu Cys Pro Phe His Lys Ser Pro Trp Phe Pro His Phe Pro
                  85                  90                  95    
 Gln Ile Leu Pro Arg Glu Trp Ser Trp Cys Gly Pro Glu Arg Pro Ala
             100                 105                 110        
 Gly Cys Ser Leu Gly Leu Lys Ala Glu Ala Ala Leu Val Gly Lys Lys
         115                 120                 125            





      <210> 976
      <211> 40
      <212> PRT
      <213> Homo sapiens


      <400> 976
 Met Trp Phe Gln Thr Arg Ser Cys Gly His His Asp Pro Val Gly Ile
   1               5                  10                  15    
 Thr Gly Val Thr Lys Val Ile Leu Pro Leu Phe Leu Cys Pro Leu Gly
              20                  25                  30        
 Met Val Glu Thr Ser Leu Met Leu
          35                  40



      <210> 977
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 977
 Met Phe Thr Leu Ala Glu Val Ala Ser Leu Asn Asp Ile Gln Pro Thr
   1               5                  10                  15    
 Tyr Arg Ile Leu Lys Pro Trp Trp Asp Val Phe Met Asp Tyr Leu Ala
              20                  25                  30        
 Val Val Met Leu Met Val Ala Ile Phe Ala Gly Thr Met Gln Leu Thr
          35                  40                  45            
 Lys Asp Gln Val Val Cys Met Pro Val Leu Pro Ser Pro Val Asn Ser
      50                  55                  60                
 Lys Ala His Thr Pro Pro Gly Asn Ala Glu Val Thr Thr Asn Ile Pro
  65                  70                  75                  80
 Gln Met Ala Ala Asp Thr Asn Gln Asp Gln Asp Gly Arg Thr Ser Lys
                  85                  90                  95    
 Arg Thr Phe Pro Leu Gly Thr His Leu Leu
             100                 105    



      <210> 978
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 978
 Met Glu Asp Leu Leu Asp Leu Asp Glu Glu Leu Arg Tyr Ser Leu Ala
   1               5                  10                  15    
 Thr Ser Arg Ala Lys Met Gly Arg Arg Ala Gln Gln Glu Ser Ala Gln
              20                  25                  30        
 Ala Glu Asn His Leu Asn Gly Lys Asn Ser Ser Leu Thr Leu Thr Gly
          35                  40                  45            
 Glu Thr Ser Ser Ala Lys Leu Pro Arg Cys Arg Gln Gly Gly Trp Ala
      50                  55                  60                
 Gly Asp Ser Val Lys Ala Ser Lys Phe Arg Arg Lys Ala Ser Glu Glu
  65                  70                  75                  80
 Ile Glu Asp Phe Arg Leu Arg Pro Gln Ser Leu Asn Gly Ser Asp Tyr
                  85                  90                  95    
 Gly Gly Asp Ile Pro Ile Ile Pro Asp Leu Glu Glu Val Gln Glu Glu
             100                 105                 110        
 Asp Phe Val Leu Gln Val Ala Ala Pro Pro Arg
         115                 120            



      <210> 979
      <211> 43
      <212> PRT
      <213> Homo sapiens


      <400> 979
 Met Pro His Asn His Leu Glu Gly Asp Ala Leu Leu Arg Val Pro Val
   1               5                  10                  15    
 Leu Cys Ile Trp Arg Ala Trp Leu Arg Ala Glu Val Gly Gly Arg Ala
              20                  25                  30        
 Pro Leu Pro Gly Arg Ser Val Gly His Arg Asn
          35                  40            



      <210> 980
      <211> 73
      <212> PRT
      <213> Homo sapiens


      <400> 980
 Met Ser Ser Lys Met Val Ile Ser Glu Pro Gly Leu Asn Trp Asp Ile
   1               5                  10                  15    
 Ser Pro Lys Asn Gly Leu Lys Thr Phe Phe Ser Arg Glu Asn Tyr Lys
              20                  25                  30        
 Asp His Ser Met Ala Pro Ser Leu Lys Glu Leu Arg Val Leu Ser Asn
          35                  40                  45            
 Arg Glu Ser Arg Gly Val Met Trp Thr Cys Trp Leu Asn Thr Gln Arg
      50                  55                  60                
 Phe Leu Gln Ile Pro Lys Leu Leu Glu
  65                  70            



      <210> 981
      <211> 206
      <212> PRT
      <213> Homo sapiens


      <400> 981
 Met Gly Thr Arg Thr Cys Phe Pro Ala Leu Gly Thr Gln Arg Gly Gln
   1               5                  10                  15    
 Ala Gly Arg Cys Gln Gly Gln Gly Pro Gly Leu Leu His Phe His Thr
              20                  25                  30        
 Pro Gly Val Ser Pro Gly Ala Phe Ser Val Ala Arg Ser Leu Ser Trp
          35                  40                  45            
 Lys Val Pro Asp His Lys Ser Thr Arg Lys Val Ser Arg Val Leu Lys
      50                  55                  60                
 Gly Gly Val Asp Pro Thr Val Ser Arg Val Leu Lys Ser Gly Val Asp
  65                  70                  75                  80
 Pro Thr Ala Ser Leu Leu Lys Gly Gly Val Asp Pro Thr Ala Ser Arg
                  85                  90                  95    
 Val Arg Lys Gly Gly Val Asp Pro Thr Ala Ser Arg Val Arg Lys Gly
             100                 105                 110        
 Gly Val Asp Pro Thr Ala Ser Leu Leu Lys Gly Gly Val Asp Pro Thr
         115                 120                 125            
 Ala Ser Arg Val Arg Lys Gly Gly Val Asp Pro Thr Ala Ser Cys Val
     130                 135                 140                
 Arg Lys Gly Gly Val Asp Pro Thr Ala Ser Leu Leu Lys Gly Gly Val
 145                 150                 155                 160
 Asp Pro Thr Val Ser His Val Arg Lys Gly Gly Val Asp Pro Gln Leu
                 165                 170                 175    
 Leu Val Tyr Arg Lys Ala Ala Trp Ser Ser Thr Arg Ser Leu Ser Val
             180                 185                 190        
 Ala Met Arg Ser His Gly Cys Glu Ser His Pro Ile Thr Phe
         195                 200                 205    



      <210> 982
      <211> 320
      <212> PRT
      <213> Homo sapiens


      <400> 982
 Met Glu Val Val Asn Ser Gly Ser Glu Val Trp Tyr Ser Asn Gly Pro
   1               5                  10                  15    
 Gly Leu Leu Val Ile Asp Cys Ala Ser Leu Glu Ile Cys Arg Arg Leu
              20                  25                  30        
 Glu Pro Tyr Met Ala Pro Ser Met Val Thr Ser Val Val Cys Ser Ser
          35                  40                  45            
 Glu Gly Arg Gly Glu Glu Val Val Trp Cys Leu Asp Asp Lys Ala Asn
      50                  55                  60                
 Ser Leu Val Met Tyr His Ser Thr Thr Tyr Gln Leu Cys Ala Arg Tyr
  65                  70                  75                  80
 Phe Cys Gly Val Pro Ser Pro Leu Arg Asp Met Phe Pro Val Arg Pro
                  85                  90                  95    
 Leu Asp Thr Glu Pro Pro Ala Ala Ser His Thr Ala Asn Pro Lys Val
             100                 105                 110        
 Pro Glu Gly Asp Ser Ile Ala Asp Val Ser Ile Met Tyr Ser Glu Glu
         115                 120                 125            
 Leu Gly Thr Gln Ile Leu Ile His Gln Glu Ser Leu Thr Asp Tyr Cys
     130                 135                 140                
 Ser Met Ser Ser Tyr Ser Ser Ser Pro Pro Arg Gln Ala Ala Arg Ser
 145                 150                 155                 160
 Pro Ser Ser Leu Pro Ser Ser Pro Ala Ser Ser Ser Ser Val Pro Phe
                 165                 170                 175    
 Ser Thr Asp Cys Glu Asp Ser Asp Met Leu His Thr Pro Gly Ala Ala
             180                 185                 190        
 Ser Asp Arg Ser Glu His Asp Leu Thr Pro Met Asp Gly Glu Thr Phe
         195                 200                 205            
 Ser Gln His Leu Gln Ala Val Lys Ile Leu Ala Val Arg Asp Leu Ile
     210                 215                 220                
 Trp Val Pro Arg Arg Gly Gly Asp Val Ile Val Ile Gly Leu Glu Lys
 225                 230                 235                 240
 Asp Ser Gly Ala Gln Arg Gly Arg Val Ile Ala Val Leu Lys Ala Arg
                 245                 250                 255    
 Glu Leu Thr Pro His Gly Val Leu Val Asp Ala Ala Val Val Ala Lys
             260                 265                 270        
 Asp Thr Val Val Cys Thr Phe Glu Asn Glu Asn Thr Glu Trp Cys Leu
         275                 280                 285            
 Ala Val Trp Arg Gly Trp Gly Ala Arg Glu Phe Asp Ile Phe Tyr Gln
     290                 295                 300                
 Ser Tyr Glu Glu Leu Gly Arg Leu Glu Ala Cys Thr Arg Lys Arg Arg
 305                 310                 315                 320





      <210> 983
      <211> 266
      <212> PRT
      <213> Homo sapiens


      <400> 983
 Met Arg Ser Cys Arg Thr Leu Ser Asp Arg Ser Leu Met Glu Gly Ser
   1               5                  10                  15    
 His Pro Met Glu Arg Gly Pro Gln His Ser Arg Gly Leu Lys Pro Gln
              20                  25                  30        
 Trp Val Leu Leu Arg Pro Pro Ala Pro Ala Trp Lys Gly Gln Val Leu
          35                  40                  45            
 Pro His Leu Leu Ser Pro Lys Lys Ser Phe Gly Leu Thr Leu Arg Leu
      50                  55                  60                
 Trp Asp Val Leu Ile Leu Glu Gly Glu Gln Val Leu Thr Ala Met Ala
  65                  70                  75                  80
 His Ala Ser Phe Lys Ile His Arg Glu His Leu Met Lys Leu Ser Trp
                  85                  90                  95    
 Ser Thr Val Trp Glu Phe Gln Glu Arg Leu Ser Gln Ser Trp Ala Leu
             100                 105                 110        
 Glu Asp Asn Ser Val Leu Arg Asn Leu Gln Thr Ser Met Lys Glu Leu
         115                 120                 125            
 Thr Lys Lys His Trp Asp Leu Pro Ser Pro Gly Glu Leu Glu Arg Gly
     130                 135                 140                
 Ser Ser Arg Val Ser Pro Gly Ile Arg Pro Leu Cys Glu Gly Asp Arg
 145                 150                 155                 160
 Leu Ala Leu Pro Ser Pro Pro Ala Gln Leu Gln Gly Leu Met Pro Ser
                 165                 170                 175    
 Ala Pro Gln Asp Lys Ser Leu Val Leu Pro Gln Pro Gly Leu Thr Gly
             180                 185                 190        
 Leu Ser Pro Trp Arg Arg Pro Arg Pro Ser Ser Thr Lys Gly Leu Pro
         195                 200                 205            
 Gln Asn Pro Gly Gln Gln Ala Ala Leu Trp Val Ala Gln Arg Ile Lys
     210                 215                 220                
 Met Trp Pro Pro Cys Phe Pro Val Arg Ser Gly Leu Val Leu His Lys
 225                 230                 235                 240
 Asn Thr Cys Ala Gly Thr Leu Cys His Thr Ser Thr Gln Thr Trp Met
                 245                 250                 255    
 Leu Gly Ser Met Val Ser Leu Leu Gln Phe
             260                 265    



      <210> 984
      <211> 143
      <212> PRT
      <213> Homo sapiens


      <400> 984
 Met Leu Leu Lys Ile Arg Asn Phe Lys Glu Asn Leu Tyr Arg Met Val
   1               5                  10                  15    
 Leu Gln Gly Val Thr Ser Pro Gly Arg Glu Leu Gly Met Ser Trp Leu
              20                  25                  30        
 Ile Ile Ala Arg Gln His Val Gln Val Pro Gly Gly Thr Asp Ser Glu
          35                  40                  45            
 Cys Ile Glu Tyr Ala Phe Leu Pro Glu Lys Arg Thr His Trp Ser Cys
      50                  55                  60                
 Arg Asp Cys Ile Gln Ser Thr Val Gly Ala Ala His Thr Gln Glu Leu
  65                  70                  75                  80
 Cys His Lys Ala Val His Gly Arg Gly Cys Trp Thr Ser Tyr Leu Val
                  85                  90                  95    
 Cys Asn Phe Lys Thr Lys Thr Lys Lys Lys Lys Asn Val Ala Ala Arg
             100                 105                 110        
 Leu Gly Gly Asp Phe Glu Met Gly Gln Ser Phe Asn Glu Phe Ile Tyr
         115                 120                 125            
 Arg Phe Cys Glu Glu Lys Ala Ser Gln Lys Val Thr Ile Ser Lys
     130                 135                 140            



      <210> 985
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 985
 Met Ser His Val Cys Leu Val Pro Gln Thr Pro Ser Leu Cys Leu Gly
   1               5                  10                  15    
 Lys Gly Thr Pro Arg Ser Arg Ser Ala Pro Phe Gln Ser Ser Gly Pro
              20                  25                  30        
 His Arg Leu Cys Ala Ser Ser Phe Ser Leu Arg Asn Tyr Leu Gly Tyr
          35                  40                  45            
 Phe Cys Arg Gly Asp Ile Thr Val Trp Leu Gln Lys His Leu Leu Gly
      50                  55                  60                
 Phe Gly Glu Val Arg Ala Gly Arg Gly Gly Leu Thr Glu Ala Gly Cys
  65                  70                  75                  80
 Pro Gly Pro Leu Arg Val Ala Asp Gly Gly Trp Ala Tyr His Leu Gln
                  85                  90                  95    
 Gly Gln Gly Gly Gly Arg Gly Ala Thr Pro Gly Arg Gly Lys Gly Cys
             100                 105                 110        
 Ala Pro Phe Gly Ile Trp Arg Phe Trp Gly Ala Gly Gly Arg Glu Phe
         115                 120                 125            
 Gln Gly Ser Ser Pro Trp Gly Lys Gly Gly Phe Lys Val Ser Gly Lys
     130                 135                 140                
 Val Gly Ala Lys Val Trp Lys Met Ser
 145                 150            



      <210> 986
      <211> 489
      <212> PRT
      <213> Homo sapiens


      <400> 986
 Met Leu Cys Pro Ala Ser Leu Asn Ile Cys Ser Val Val Ser Leu Ser
   1               5                  10                  15    
 Ala Ser Pro Arg Thr His Glu Gly Gly Thr Lys Leu Leu Ala Leu Ser
              20                  25                  30        
 Ala Lys Gly Arg Leu Met Thr Cys Ser Leu Asp Leu Asp Ser Glu Met
          35                  40                  45            
 Pro Gly Pro Ala Arg Met Thr Thr Glu Ser Ala Gly Gln Lys Ile Lys
      50                  55                  60                
 Glu Leu Leu Ser Gly Ile Gly Asn Ile Ser Glu Arg Val Ser Phe Leu
  65                  70                  75                  80
 Lys Lys Ala Val Asp Gln Arg Asn Lys Ala Leu Thr Ser Leu Asn Glu
                  85                  90                  95    
 Ala Met Asn Val Ser Cys Ala Leu Leu Ser Ser Gly Thr Gly Pro Arg
             100                 105                 110        
 Pro Ile Ser Cys Thr Thr Ser Thr Thr Trp Ser Arg Leu Gln Thr Gln
         115                 120                 125            
 Asp Val Leu Met Ala Thr Cys Val Leu Glu Asn Ser Ser Ser Phe Ser
     130                 135                 140                
 Leu Asp Gln Gly Trp Thr Leu Cys Ile Gln Val Leu Thr Ser Ser Cys
 145                 150                 155                 160
 Ala Leu Asp Leu Asp Ser Ala Cys Ser Ala Ile Thr Tyr Thr Ile Pro
                 165                 170                 175    
 Val Asp Gln Leu Gly Pro Gly Ala Arg Arg Glu Val Thr Leu Pro Leu
             180                 185                 190        
 Gly Pro Gly Glu Asn Gly Gly Leu Asp Leu Pro Val Thr Val Ser Cys
         195                 200                 205            
 Thr Leu Phe Tyr Ser Leu Arg Glu Val Val Gly Gly Ala Leu Ala Pro
     210                 215                 220                
 Ser Asp Ser Glu Asp Pro Phe Leu Asp Glu Cys Pro Ser Asp Val Leu
 225                 230                 235                 240
 Pro Glu Gln Glu Gly Val Cys Leu Pro Leu Ser Arg His Thr Val Asp
                 245                 250                 255    
 Met Leu Gln Cys Leu Arg Phe Pro Gly Leu Ala Leu Pro His Thr Arg
             260                 265                 270        
 Ala Pro Ser Pro Leu Gly Pro Thr Arg Asp Pro Val Ala Thr Phe Leu
         275                 280                 285            
 Glu Thr Cys Arg Glu Pro Gly Ser Gln Pro Ala Gly Pro Ala Ser Leu
     290                 295                 300                
 Arg Ala Glu Tyr Leu Pro Pro Ser Val Ala Ser Ile Lys Val Ser Ala
 305                 310                 315                 320
 Glu Leu Leu Arg Ala Ala Leu Lys Asp Gly His Ser Gly Val Pro Leu
                 325                 330                 335    
 Cys Cys Ala Thr Leu Gln Trp Leu Leu Ala Glu Asn Ala Ala Val Asp
             340                 345                 350        
 Val Val Arg Ala Arg Ala Leu Ser Ser Ile Gln Gly Val Ala Pro Asp
         355                 360                 365            
 Gly Ala Asn Val His Leu Ile Val Arg Glu Val Ala Met Thr Asp Leu
     370                 375                 380                
 Cys Pro Ala Gly Pro Ile Gln Ala Val Glu Ile Gln Val Glu Ser Ser
 385                 390                 395                 400
 Ser Leu Ala Asp Ile Cys Arg Ala His His Ala Val Val Gly Arg Met
                 405                 410                 415    
 Gln Thr Met Val Thr Glu Gln Ala Ala Gln Gly Ser Ser Ala Pro Asp
             420                 425                 430        
 Leu Arg Val Gln Tyr Leu Arg Gln Ile His Ala Asn His Glu Thr Leu
         435                 440                 445            
 Leu Arg Glu Val Gln Thr Leu Arg Asp Arg Leu Cys Thr Glu Asp Glu
     450                 455                 460                
 Ala Ser Ser Cys Ala Thr Ala Gln Arg Leu Leu Gln Val Tyr Arg Gln
 465                 470                 475                 480
 Leu Arg His Pro Ser Leu Ile Leu Leu
                 485                



      <210> 987
      <211> 192
      <212> PRT
      <213> Homo sapiens


      <400> 987
 Met Ala Cys Gly Ala Thr Leu Lys Arg Pro Met Glu Phe Glu Ala Ala
   1               5                  10                  15    
 Leu Leu Ser Pro Gly Ser Pro Lys Arg Arg Arg Cys Ala Pro Leu Pro
              20                  25                  30        
 Gly Pro Thr Pro Gly Leu Arg Pro Pro Asp Ala Glu Pro Pro Pro Pro
          35                  40                  45            
 Phe Gln Thr Gln Thr Pro Pro Gln Ser Leu Gln Gln Pro Ala Pro Pro
      50                  55                  60                
 Gly Ser Glu Arg Arg Leu Pro Thr Pro Glu Gln Ile Phe Gln Asn Ile
  65                  70                  75                  80
 Lys Gln Glu Tyr Ser Arg Tyr Gln Arg Trp Arg His Leu Glu Val Val
                  85                  90                  95    
 Leu Asn Gln Ser Glu Ala Cys Ala Ser Glu Ser Gln Pro His Ser Ser
             100                 105                 110        
 Ala Leu Thr Ala Pro Ser Ser Pro Gly Ser Ser Trp Met Lys Lys Asp
         115                 120                 125            
 Gln Pro Thr Phe Thr Leu Arg Gln Val Gly Ile Ile Cys Glu Arg Leu
     130                 135                 140                
 Leu Lys Asp Tyr Glu Asp Lys Ile Arg Glu Glu Tyr Glu Gln Ile Leu
 145                 150                 155                 160
 Asn Thr Lys Leu Ala Glu Gln Tyr Glu Ser Phe Val Lys Phe Thr His
                 165                 170                 175    
 Asp Gln Ile Met Arg Arg Tyr Gly Thr Arg Pro Thr Ser Tyr Val Ser
             180                 185                 190        





      <210> 988
      <211> 67
      <212> PRT
      <213> Homo sapiens


      <400> 988
 Met Ser His Leu Met Thr Leu Ala Ile Ile Gln Thr Gly Lys Met Phe
   1               5                  10                  15    
 Ile Leu Ile Ser Ala Thr Ala Thr Leu Lys Pro Glu Val Ser Glu Leu
              20                  25                  30        
 Trp Leu Met Ser Leu Asp Val Gly Gln Pro Tyr Cys Glu Cys Gln Pro
          35                  40                  45            
 Trp Phe Leu Asn Val Leu Leu Glu Glu Ser His Phe Thr Ser Ser Leu
      50                  55                  60                
 Ser Val Ser
  65        



      <210> 989
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 989
 Met Gly Lys Gly Cys Val Arg Val Cys Ala Lys Thr Arg Lys Ala Arg
   1               5                  10                  15    
 Ile Ser Glu Asn Lys Thr Leu Val Leu Ala Trp Pro Gly Thr Ala Glu
              20                  25                  30        
 Asp Arg Gly Gly Ser Ala Lys Ala Gly Gln Gly Pro Val Gln Pro Ser
          35                  40                  45            
 Leu Leu Arg Leu Arg
      50            



      <210> 990
      <211> 76
      <212> PRT
      <213> Homo sapiens


      <400> 990
 Met Lys Gln Thr Ile Ala Ile Phe Lys Ile Met Asn Leu Ser Ile Ile
   1               5                  10                  15    
 Leu Pro Asn Ser Phe Leu His Leu Cys Asn Phe Ser Leu Phe Leu Leu
              20                  25                  30        
 Pro Leu Pro Val Pro Ser Gln Pro Leu Ile Cys Ser Gly Asn Tyr Gln
          35                  40                  45            
 Ser Ser Phe Cys His Tyr Arg Leu Ile Cys Ile Phe Lys Glu Ile Tyr
      50                  55                  60                
 Ile His Gly Thr Ile His His Leu Cys Phe Val Val
  65                  70                  75    



      <210> 991
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 991
 Met Gly Arg Lys Arg Leu Ile Thr Asp Ser Tyr Pro Val Val Lys Arg
   1               5                  10                  15    
 Arg Glu Gly Pro Ala Gly His Ser Lys Gly Glu Leu Ala Pro Glu Leu
              20                  25                  30        
 Gly Glu Glu Pro Gln Pro Arg Asp Glu Glu Glu Ala Glu Leu Glu Leu
          35                  40                  45            
 Leu Arg Gln Phe Asp Leu Ala Trp Gln Tyr Gly Pro Cys Thr Gly Glu
      50                  55                  60                
 Asn Pro Pro Ser Pro Thr Glu Ala Pro Leu Pro Ala Ser His Pro His
  65                  70                  75                  80
 Val Ser Glu Val Thr Gln Ala Leu Ala
                  85                



      <210> 992
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 992
 Met Asn Thr Lys Ser Glu Ile Arg Pro Arg Trp Cys Leu Gln Ala Ser
   1               5                  10                  15    
 Trp Glu Asp Leu Met Lys Met Leu Lys Arg Lys Trp Arg Thr Phe Ser
              20                  25                  30        
 Gly Phe Pro Ala Trp Lys Lys Arg Thr Leu Leu Gly Arg Gly Pro Ala
          35                  40                  45            
 Pro Ser Leu Ala Ala Thr Ser Leu Pro Leu Ser His Lys Ser Ala Ser
      50                  55                  60                
 Ile Cys Ala Ala Leu Trp Met Arg Cys Trp Arg Ala Thr Gly Met Ser
  65                  70                  75                  80
 Leu Ala Gly Ser Ala Pro Thr Thr Ala Ser Gly Ser Ser Ser Thr Arg
                  85                  90                  95    
 Ser Trp Phe Ser Thr Ser Ser Pro Gln Arg Ser Ala Ser Trp His Ser
             100                 105                 110        
 Gly Ala Pro Ser Cys Arg Ser Trp Arg Leu Pro Cys Ser Trp Leu Ser
         115                 120                 125            
 Thr Arg Met Pro Trp Arg Ser Gly Trp Arg Lys Thr Cys Thr Pro Ala
     130                 135                 140                
 Cys Ser Gly Cys Lys Leu Cys Cys Arg Thr Ser Ala Arg Cys Leu Pro
 145                 150                 155                 160
 Pro Arg Cys His Pro Pro Ala Leu Ala Gly Thr Leu Leu Arg Thr Pro
                 165                 170                 175    
 Glu Gly Arg Ala His Ala Arg Gly Leu Leu Leu Glu Ala Gly Gly Ala
             180                 185                 190        
 Leu His Cys Gln Met Ala Trp Ala Ile Arg Ala His Val Gly Val Val
         195                 200                 205            
 Pro Ser Gly Pro Ala Val Ser Cys Pro His Ser Val Pro Glu Gly Pro
     210                 215                 220                
 Gly Gln Pro Leu Gly Glu Arg Leu Glu Asn Thr Glu Gly Ser Ser Thr
 225                 230                 235                 240
 Gly Arg Pro Ala Leu
                 245



      <210> 993
      <211> 289
      <212> PRT
      <213> Homo sapiens


      <400> 993
 Met Ile Ile Asn Trp Asn Gln Val Ser Val Leu Trp Lys Cys Leu Leu
   1               5                  10                  15    
 Lys Gln Ser Ala Ser Tyr Gln Asp Arg Arg Gln Ser Gly Arg Arg Ala
              20                  25                  30        
 Ser Met Lys Glu Thr Asn Arg Arg Lys Ser Leu His Pro Ile His Gln
          35                  40                  45            
 Gly Ile Thr Glu Leu Ser Arg Ser Ile Ser Val Asp Leu Ala Glu Ser
      50                  55                  60                
 Lys Arg Leu Gly Cys Leu Leu Leu Ser Ser Phe Gln Phe Ser Ile Gln
  65                  70                  75                  80
 Lys Leu Glu Pro Phe Leu Arg Asp Thr Lys Gly Phe Ser Leu Glu Ser
                  85                  90                  95    
 Phe Arg Ala Lys Ala Ser Ser Leu Ser Glu Glu Leu Lys His Phe Ala
             100                 105                 110        
 Asp Gly Leu Glu Thr Asp Gly Thr Leu Gln Lys Cys Phe Glu Asp Ser
         115                 120                 125            
 Asn Gly Lys Ala Ser Asp Phe Ser Leu Glu Ala Ser Val Ala Glu Met
     130                 135                 140                
 Lys Glu Tyr Ile Thr Lys Phe Ser Leu Glu Arg Gln Thr Trp Asp Gln
 145                 150                 155                 160
 Leu Leu Leu His Tyr Gln Gln Glu Ala Lys Glu Ile Leu Ser Arg Gly
                 165                 170                 175    
 Ser Thr Glu Ala Lys Ile Thr Glu Val Lys Val Glu Pro Met Thr Tyr
             180                 185                 190        
 Leu Gly Ser Ser Gln Asn Glu Val Leu Asn Thr Lys Pro Asp Tyr Gln
         195                 200                 205            
 Lys Ile Leu Gln Asn Gln Ser Lys Val Phe Asp Cys Met Glu Leu Val
     210                 215                 220                
 Met Asp Glu Leu Gln Gly Ser Val Lys Gln Leu Gln Ala Phe Met Asp
 225                 230                 235                 240
 Glu Ser Thr Gln Cys Phe Gln Lys Val Ser Val Gln Leu Gly Lys Arg
                 245                 250                 255    
 Ser Met Gln Gln Leu Asp Pro Ser Pro Ala Arg Lys Leu Leu Lys Leu
             260                 265                 270        
 Gln Leu Gln Asn Pro Pro Ala Ile His Gly Ser Gly Ser Gly Ser Cys
         275                 280                 285            
 Gln
    



      <210> 994
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 994
 Met Trp Val Thr Lys Arg Pro Val Pro Val Lys Gln Asn Ala Gly Val
   1               5                  10                  15    
 Met Ile Ile His Val Tyr Gly Leu Pro Gly His Thr Leu Ile Trp Val
              20                  25                  30        
 Val Leu Gln Arg Ser Lys Gln Pro Ile Pro Val Phe Ile Lys Leu Ile
          35                  40                  45            
 Leu Gln Leu Glu Lys Leu Asn Arg Ser Thr Lys Ser Gly Ile Gly Val
      50                  55                  60                
 Ser Arg Arg Glu Lys
  65                



      <210> 995
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 995
 Met Asn Ala Thr Phe Leu Asn His Ser Gly Leu Glu Glu Val Asp Gly
   1               5                  10                  15    
 Val Gly Gly Gly Ala Gly Ala Ala Leu Gly Asn Arg Thr His Gly Leu
              20                  25                  30        
 Gly Thr Trp Leu Gly Cys Cys Pro Gly Gly Ala Pro Leu Ala Ala Ser
          35                  40                  45            
 Asp Gly Val Pro Ala Gly Leu Ala Pro Asp Glu Arg Ser Leu Trp Val
      50                  55                  60                
 Ser Arg Val Ala Gln Ile Ala Val Leu Cys Val Leu Ser Leu Thr Val
  65                  70                  75                  80
 Val Phe Gly Val Phe Phe Leu Gly Cys Asn Leu Leu Ile Lys Ser Glu
                  85                  90                  95    
 Ser Met Ile Asn Phe Leu Val Gln Glu Arg Arg Pro Ser Lys Asp Val
             100                 105                 110        
 Gly Ala Ala Ile Leu Gly Leu Tyr
         115                 120



      <210> 996
      <211> 95
      <212> PRT
      <213> Homo sapiens


      <400> 996
 Met Asp Gln Thr Leu Ser Pro Ser Ser Pro Thr Cys Glu Ser Val Gln
   1               5                  10                  15    
 Thr Phe Gln Asn Phe Ile Ala Pro Ala Pro Cys Pro Arg Glu Lys Gln
              20                  25                  30        
 Lys Thr Thr Ser Trp Ala Leu Asn His Gln Pro Leu Phe Lys Glu Ser
          35                  40                  45            
 Gln Asp Ser Val Asn Ile Phe Phe Phe Pro Pro Lys Ile Lys Met Cys
      50                  55                  60                
 Leu Gln Tyr Asn Leu Leu Ser Lys Ile Glu Ala Phe Tyr Leu Ser Leu
  65                  70                  75                  80
 Leu Gln Asn Arg Asp Tyr Met Glu Thr Phe Asn Leu Glu Ser Ile
                  85                  90                  95



      <210> 997
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 997
 Met Ala Glu Glu Glu Gln Gly Ser Thr Ser Cys Arg Glu Arg Arg Ser
   1               5                  10                  15    
 Ile Arg Phe Lys Met Lys Asn His Ser Pro Asp Asp Thr Ile Lys Glu
              20                  25                  30        
 Asn Val Thr Ile Ser Asn Ile Arg Thr Arg Lys Ile Asn Gln Leu Pro
          35                  40                  45            
 Glu Thr Glu Arg Asn Leu Leu Glu His Gly Leu Met Tyr Ile Arg Leu
      50                  55                  60                
 Asn Ala Ala Phe Cys Ser Leu Val Ala His Ser Leu Phe Gly Phe Ile
  65                  70                  75                  80
 Leu Lys Ala Thr
                



      <210> 998
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 998
 Met Ser Met Glu Phe Thr Gln Ile Thr Ser Arg Asn Leu Trp Asn Lys
   1               5                  10                  15    
 Lys Phe Thr Thr Pro Trp Pro His Thr Lys Met Leu Gly Cys Arg Lys
              20                  25                  30        
 Pro Glu Ala Glu Ser Ser Ile Ile Thr Val Lys Ser Pro Pro Ser Ala
          35                  40                  45            
 Asp Pro Thr Asn Ser His Ser Ala Ser His His Leu Lys Lys Thr His
      50                  55                  60                
 Val Ser Asn Tyr Tyr Thr Ser Ser Glu Tyr Trp Lys Met Val His Ser
  65                  70                  75                  80
 Ser Tyr Val Leu Ile Cys Leu Ser Cys Val
                  85                  90



      <210> 999
      <211> 419
      <212> PRT
      <213> Homo sapiens


      <400> 999
 Met Tyr Lys His Val Phe Gln Arg Pro Pro Asp Arg His Ser Asp Phe
   1               5                  10                  15    
 Ser Arg Leu Ala Arg Val Leu Thr Gly Asn Ala Ile Ala Leu Val Leu
              20                  25                  30        
 Gly Gly Gly Gly Ala Arg Gly Cys Ala Gln Val Gly Val Leu Lys Ala
          35                  40                  45            
 Leu Ala Glu Cys Gly Ile Pro Val Asp Met Val Gly Gly Thr Ser Ile
      50                  55                  60                
 Gly Ala Phe Val Gly Ala Leu Tyr Ser Glu Glu Arg Asn Tyr Ser Gln
  65                  70                  75                  80
 Met Arg Ile Arg Ala Lys Gln Trp Ala Glu Gly Met Thr Ser Leu Met
                  85                  90                  95    
 Lys Ala Ala Leu Asp Leu Thr Tyr Pro Ile Thr Ser Met Phe Ser Gly
             100                 105                 110        
 Ala Gly Phe Asn Ser Ser Ile Phe Ser Val Phe Lys Asp Gln Gln Ile
         115                 120                 125            
 Glu Asp Leu Trp Ile Pro Tyr Phe Ala Ile Thr Thr Asp Ile Thr Ala
     130                 135                 140                
 Ser Ala Met Arg Val His Thr Asp Gly Ser Leu Trp Arg Tyr Val Arg
 145                 150                 155                 160
 Ala Ser Met Ser Leu Ser Gly Tyr Met Pro Pro Leu Cys Asp Pro Lys
                 165                 170                 175    
 Asp Gly His Leu Leu Met Asp Gly Gly Tyr Ile Asn Asn Leu Pro Ala
             180                 185                 190        
 Asp Val Ala Arg Ser Met Gly Ala Lys Val Val Ile Ala Ile Asp Val
         195                 200                 205            
 Gly Ser Arg Asp Glu Thr Asp Leu Thr Asn Tyr Gly Asp Ala Leu Ser
     210                 215                 220                
 Gly Trp Trp Leu Leu Trp Lys Arg Trp Asn Pro Leu Ala Thr Lys Val
 225                 230                 235                 240
 Lys Val Leu Asn Met Ala Glu Ile Gln Thr Arg Leu Ala Tyr Val Cys
                 245                 250                 255    
 Cys Val Arg Gln Leu Glu Val Val Lys Ser Ser Asp Tyr Cys Glu Tyr
             260                 265                 270        
 Leu Arg Pro Pro Ile Asp Ser Tyr Ser Thr Leu Asp Phe Gly Lys Phe
         275                 280                 285            
 Asn Glu Ile Cys Glu Val Gly Tyr Gln His Gly Arg Thr Val Phe Asp
     290                 295                 300                
 Ile Trp Gly Arg Ser Gly Val Leu Glu Lys Met Leu Arg Asp Gln Gln
 305                 310                 315                 320
 Gly Pro Ser Lys Lys Pro Ala Ser Ala Val Leu Thr Cys Pro Asn Ala
                 325                 330                 335    
 Ser Phe Thr Asp Leu Ala Glu Ile Val Ser Arg Ile Glu Pro Ala Lys
             340                 345                 350        
 Pro Ala Met Val Asp Asp Glu Ser Asp Tyr Gln Thr Glu Tyr Glu Glu
         355                 360                 365            
 Glu Leu Leu Asp Val Pro Arg Asp Ala Tyr Ala Asp Phe Gln Ser Thr
     370                 375                 380                
 Ser Ala Gln Gln Gly Ser Asp Leu Glu Asp Glu Ser Ser Leu Arg His
 385                 390                 395                 400
 Arg His Pro Ser Leu Ala Phe Pro Lys Leu Ser Glu Gly Ser Ser Asp
                 405                 410                 415    
 Gln Asp Gly
            



      <210> 1000
      <211> 96
      <212> PRT
      <213> Homo sapiens


      <400> 1000
 Met Pro Glu Pro Lys Ala Asn Gly His Ile Leu Leu Leu Lys Lys Val
   1               5                  10                  15    
 Ser Glu Lys Thr Ile Pro Asn Pro Lys Pro Val Pro Phe Leu Trp Leu
              20                  25                  30        
 Ser Gly Leu Asp Arg Gly Trp Asn Ile Cys Arg Asp Phe Ser Gly Gly
          35                  40                  45            
 His Gln Leu Pro Gly Phe Tyr Leu His Asp Arg Ile Arg Gln Thr Pro
      50                  55                  60                
 Val Pro Leu Pro Ala Glu Leu Arg Leu Arg His Val Pro His Pro Arg
  65                  70                  75                  80
 Leu Gln Leu Ser Ser Arg Arg Pro Arg Ala Pro Thr Arg Pro Arg Thr
                  85                  90                  95    





      <210> 1001
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 1001
 Met Ala Ala Leu Cys Arg Thr Arg Ala Val Ala Ala Glu Ser His Phe
   1               5                  10                  15    
 Leu Arg Val Phe Leu Phe Phe Arg Pro Phe Arg Gly Val Gly Thr Glu
              20                  25                  30        
 Ser Gly Ser Glu Ser Gly Ser Ser Asn Ala Lys Glu Pro Lys Thr Arg
          35                  40                  45            
 Ala Gly Gly Phe Ala Ser Ala Leu Glu Arg His Ser Glu Leu Leu Gln
      50                  55                  60                
 Lys Met Gly Pro Ala Lys Asp Lys Leu Val Ile Gly Arg Ile Phe His
  65                  70                  75                  80
 Ile Val Glu Asn Asp Leu Tyr Ile Asp Phe Gly Gly Lys Phe His Cys
                  85                  90                  95    
 Val Cys Arg Arg Pro Glu Val Asp Gly Glu Lys Tyr Gln Lys Gly Thr
             100                 105                 110        
 Arg Val Arg Leu Arg Leu Leu Asp Leu Glu Leu Thr Ser Arg Phe Leu
         115                 120                 125            
 Gly Ala Thr Thr Asp Thr Thr Val Leu Glu Ala Asn Ala Val Leu Leu
     130                 135                 140                
 Gly Ile Gln Glu Ser Lys Asp Ser Arg Ser Lys Glu Glu His His Glu
 145                 150                 155                 160
 Lys
    



      <210> 1002
      <211> 341
      <212> PRT
      <213> Homo sapiens


      <400> 1002
 Met Lys Val Leu Val Ala Ser Gly Thr Ile Ser Glu Trp Leu Ala Gly
   1               5                  10                  15    
 Lys Phe His Arg Ile Val Ser Ala Ala Leu Lys Ile Trp Lys Met Ser
              20                  25                  30        
 Val Leu Leu Glu Leu Arg Arg Phe Tyr Glu Asp Gly Ala Ile Val Leu
          35                  40                  45            
 Gly Glu Glu Ala Asn Met Leu Ala Gly Met Leu Leu Gly Leu Asn Ala
      50                  55                  60                
 Ile Asp Phe Ser Phe Cys Leu Lys Gly Glu Gly Leu Asp Gly Ser Phe
  65                  70                  75                  80
 Pro Ala Val Ile Asp Tyr Thr Pro Tyr Leu Lys Tyr Ile Gln Ser Ser
                  85                  90                  95    
 Asp Ser Ile Ser Ser Asp Glu Glu Glu Leu Arg Thr Leu Gly Ser Ser
             100                 105                 110        
 Gly Ser Glu Ser Ser Thr Pro Glu Asn Val Gly Pro Pro Phe Leu Met
         115                 120                 125            
 Asp Glu Asn Ser Trp Phe Asn Lys Cys Lys Arg Val Lys Gln Lys Tyr
     130                 135                 140                
 Gln Leu Thr Leu Glu Gln Lys Gly Tyr Leu Glu Glu Leu Leu Arg Leu
 145                 150                 155                 160
 Arg Glu Asn Gln Leu Ser Glu Ser Val Ser Gln Asn Lys Ile Leu Leu
                 165                 170                 175    
 Gln Arg Ile Glu Asp Ser Asp Leu Ala His Lys Leu Glu Lys Glu Gln
             180                 185                 190        
 Leu Glu Tyr Ile Ile Val Glu Leu Gln Asp Gln Leu Thr Val Leu Lys
         195                 200                 205            
 Asn Asn Asp Leu Arg Ser Arg Gln Glu Leu Thr Ala His Leu Thr Asn
     210                 215                 220                
 Gln Trp Pro Ser Pro Gly Ala Leu Asp Val Asn Ala Val Ala Leu Asp
 225                 230                 235                 240
 Thr Leu Leu Tyr Arg Lys His Asn Lys Gln Gly Tyr Glu Lys Ser Tyr
                 245                 250                 255    
 Gln Ser Leu Asp Gln Leu Ser Ala Glu Val Ser Leu Ser Gln Thr Ser
             260                 265                 270        
 Leu Asp Pro Gly Gln Ser Gln Glu Gly Asp Gly Lys Gln Asp Thr Leu
         275                 280                 285            
 Asn Val Met Ser Glu Gly Lys Glu Asp Thr Pro Ser Leu Leu Gly Leu
     290                 295                 300                
 Cys Gly Ser Leu Thr Ser Val Ala Ser Tyr Lys Phe Leu Thr Ser Leu
 305                 310                 315                 320
 Lys Phe Asn Asp Tyr Leu Ala Ser Pro Thr Thr Glu Met Thr Ser Pro
                 325                 330                 335    
 Gly Leu Thr Pro Ser
             340    



      <210> 1003
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 1003
 Met Arg Leu Gly Cys Ser Pro Ser Leu Ala Val Glu Gly Met Pro Arg
   1               5                  10                  15    
 Leu Ala Gln Glu Ser Arg Val Leu Ser Gly Ser Thr Pro Ile Cys Cys
              20                  25                  30        
 Val Ile Leu Gly Pro Gly Arg Asp Pro Ser Gly Leu Cys Tyr Trp Arg
          35                  40                  45            
 Lys Gly Lys Trp Leu Val Arg Val Gly Pro Gln Pro Ser Leu Pro Gly
      50                  55                  60                
 Gly Leu Arg Val Gly Gly Leu Trp Gly Lys Ala Arg Ala Gly Pro Gly
  65                  70                  75                  80
 Glu Ser Leu Gly Ser Ser Leu Val Asn Arg Val Pro Ser Ser Gln Ser
                  85                  90                  95    
 Arg Gly Lys Ala Arg His Met Pro Leu Ile Trp Glu Leu Gly Leu Thr
             100                 105                 110        
 Pro Ser Pro Ser Pro Ala His Leu Glu His Val Ala Leu Ala His Leu
         115                 120                 125            
 Pro Cys Gly Trp Thr Leu Ser Ser Pro Gly Ser
     130                 135                



      <210> 1004
      <211> 667
      <212> PRT
      <213> Homo sapiens


      <400> 1004
 Met Pro Glu Lys Val Thr Arg Phe Cys Pro Leu Glu Gly Lys Ala Asn
   1               5                  10                  15    
 Lys Asn Val Gln Trp Asp Glu Asp Ser Val Glu Tyr Met Pro Ala Asn
              20                  25                  30        
 Pro Val Arg Ile Ala Phe Val Leu Val Val His Gly Arg Ala Ser Arg
          35                  40                  45            
 Gln Leu Gln Arg Met Phe Lys Ala Ile Tyr His Lys Asp His Phe Tyr
      50                  55                  60                
 Tyr Ile His Val Asp Lys Arg Ser Asn Cys Leu His Arg Gln Val Leu
  65                  70                  75                  80
 Gln Val Ser Arg Gln Tyr Ser Asn Val Arg Val Thr Pro Trp Arg Met
                  85                  90                  95    
 Ala Thr Ile Trp Gly Gly Ala Ser Leu Leu Ser Thr Tyr Leu Gln Ser
             100                 105                 110        
 Met Arg Asp Leu Leu Glu Met Thr Asp Trp Pro Trp Asp Phe Phe Ile
         115                 120                 125            
 Asn Leu Ser Ala Ala Asp Tyr Pro Ile Arg Thr Asn Asp Gln Leu Val
     130                 135                 140                
 Ala Phe Leu Ser Arg Tyr Arg Asp Met Asn Phe Leu Lys Ser His Gly
 145                 150                 155                 160
 Arg Asp Asn Ala Arg Phe Ile Arg Lys Gln Gly Leu Asp Arg Leu Phe
                 165                 170                 175    
 Leu Glu Cys Asp Ala His Met Trp Arg Leu Gly Asp Arg Arg Ile Pro
             180                 185                 190        
 Glu Gly Ile Ala Val Asp Gly Gly Ser Asp Trp Phe Leu Leu Asn Arg
         195                 200                 205            
 Arg Phe Val Glu Tyr Val Thr Phe Ser Thr Asp Asp Leu Val Thr Lys
     210                 215                 220                
 Met Lys Gln Phe Tyr Ser Tyr Thr Leu Leu Pro Ala Glu Ser Phe Phe
 225                 230                 235                 240
 His Thr Val Leu Glu Asn Ser Pro His Cys Asp Thr Met Val Asp Asn
                 245                 250                 255    
 Asn Leu Arg Ile Thr Asn Trp Asn Arg Lys Leu Gly Cys Lys Cys Gln
             260                 265                 270        
 Tyr Lys His Ile Val Asp Trp Cys Gly Cys Ser Pro Asn Asp Phe Lys
         275                 280                 285            
 Pro Gln Asp Phe His Arg Phe Gln Gln Thr Ala Arg Pro Thr Phe Phe
     290                 295                 300                
 Ala Arg Lys Phe Glu Ala Val Val Asn Gln Glu Ile Ile Gly Gln Leu
 305                 310                 315                 320
 Asp Tyr Tyr Leu Tyr Gly Asn Tyr Pro Ala Gly Thr Pro Gly Leu Arg
                 325                 330                 335    
 Ser Tyr Trp Glu Asn Val Tyr Asp Glu Pro Asp Gly Ile His Ser Leu
             340                 345                 350        
 Ser Asp Val Thr Leu Thr Leu Tyr His Ser Phe Ala Arg Leu Gly Leu
         355                 360                 365            
 Arg Arg Ala Glu Thr Ser Leu His Thr Asp Gly Glu Asn Ser Cys Arg
     370                 375                 380                
 Tyr Tyr Pro Met Gly His Pro Ala Ser Val His Leu Tyr Phe Leu Ala
 385                 390                 395                 400
 Asp Arg Phe Gln Gly Phe Leu Ile Lys His His Ala Thr Asn Leu Ala
                 405                 410                 415    
 Val Ser Lys Leu Glu Thr Leu Glu Thr Trp Val Met Pro Lys Lys Val
             420                 425                 430        
 Phe Lys Ile Ala Ser Pro Pro Ser Asp Phe Gly Arg Leu Gln Phe Ser
         435                 440                 445            
 Glu Val Gly Thr Asp Trp Asp Ala Lys Glu Arg Leu Phe Arg Asn Phe
     450                 455                 460                
 Gly Gly Leu Leu Gly Pro Met Asp Glu Pro Val Gly Met Gln Lys Trp
 465                 470                 475                 480
 Gly Lys Gly Pro Asn Val Thr Val Thr Val Ile Trp Val Asp Pro Val
                 485                 490                 495    
 Asn Val Ile Ala Ala Thr Tyr Asp Ile Leu Ile Glu Ser Thr Ala Glu
             500                 505                 510        
 Phe Thr His Tyr Lys Pro Pro Leu Asn Leu Pro Leu Arg Pro Gly Val
         515                 520                 525            
 Trp Thr Val Lys Ile Leu His His Trp Val Pro Val Ala Glu Thr Lys
     530                 535                 540                
 Phe Leu Val Ala Pro Leu Thr Phe Ser Asn Arg Gln Pro Ile Lys Pro
 545                 550                 555                 560
 Glu Glu Ala Leu Lys Leu His Asn Gly Pro Leu Arg Asn Ala Tyr Met
                 565                 570                 575    
 Glu Gln Ser Phe Gln Ser Leu Asn Pro Val Leu Ser Leu Pro Ile Asn
             580                 585                 590        
 Pro Ala Gln Val Glu Gln Ala Arg Arg Asn Ala Ala Ser Thr Gly Thr
         595                 600                 605            
 Ala Leu Glu Gly Trp Leu Asp Ser Leu Val Gly Gly Met Trp Thr Ala
     610                 615                 620                
 Met Asp Ile Cys Ala Thr Gly Pro Thr Ala Cys Pro Val Met Gln Thr
 625                 630                 635                 640
 Cys Ser Gln Thr Ala Trp Ser Ser Phe Ser Pro Asp Pro Lys Ser Glu
                 645                 650                 655    
 Leu Gly Ala Val Lys Pro Asp Gly Arg Leu Arg
             660                 665        



      <210> 1005
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 1005
 Met Thr Ala Gly Asn Val Pro Trp Gln Ala Thr Val Thr Pro Val Glu
   1               5                  10                  15    
 Lys His Cys Val Met Ser Val Gln Leu Pro Ser Gln Lys His Arg Ala
              20                  25                  30        
 Cys Thr Arg Trp Ser Phe Gly Tyr Ile Ser Leu Ser Pro Ser Val Pro
          35                  40                  45            
 Val Cys Ser Leu Val Ser Val Pro Ile Gly Lys Glu Ser Phe Gly Val
      50                  55                  60                
 Pro Ser Leu Pro Arg Cys Val Tyr Leu Thr Val Gly Thr Pro Arg
  65                  70                  75                



      <210> 1006
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 1006
 Met Leu Ser Ser Leu Pro Ala Leu Pro His Leu Ser Leu Pro Val Gln
   1               5                  10                  15    
 Thr Ser Thr Leu Leu Ser Ser Thr Pro Pro Ser Pro Asn Ala Cys Arg
              20                  25                  30        
 Pro Ser Ile His Ser Val Ser Ser Cys Val Val Ser Asp Arg Pro Ser
          35                  40                  45            
 Pro Asp Leu Leu Gln Asp Cys Leu Leu Thr Leu Pro His Ser Leu Val
      50                  55                  60                
 Pro Gly Ser Ser Ser Phe Cys Pro Thr His Ser Gln Cys Arg Glu Arg
  65                  70                  75                  80
 Arg Gln Gly Lys Asp Gln Asp Ser Val Ser Ser Glu Val Ala Thr His
                  85                  90                  95    
 Lys Glu Ala Val Val Ser Leu Pro Arg Pro Leu Met Arg Leu Lys Leu
             100                 105                 110        
 Ala Ser Pro Trp Arg Arg Gln Ile Ser Gly
         115                 120        



      <210> 1007
      <211> 75
      <212> PRT
      <213> Homo sapiens


      <400> 1007
 Met Pro Arg Gly Arg Arg Leu Gly Met Val Phe Ala Pro Pro Arg Pro
   1               5                  10                  15    
 Gly Gln Arg Gln Ala Gly Ala Pro Trp Val Pro Glu Arg Arg Lys Arg
              20                  25                  30        
 Arg Pro Asp Gly Asp Thr Phe Leu Leu Ser Phe Leu Ser Thr Thr Trp
          35                  40                  45            
 Leu Lys Thr Trp Arg Ser Gln Gln Tyr Lys Glu Ser Lys Ser Arg Ser
      50                  55                  60                
 Cys Ala Arg Glu Gln Met Asn Ser Ser Ser Cys
  65                  70                  75



      <210> 1008
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 1008
 Met Ala Ala Ser Val Tyr Arg Val Phe Leu Lys Leu Cys Glu Glu Trp
   1               5                  10                  15    
 Pro Val Asp Glu Thr Lys Arg Gly Arg Asp Leu Gly Ala Tyr Leu Arg
              20                  25                  30        
 Gln Arg Val Ala Gln Ala Phe Arg Glu Gly Glu Asn Thr Gln Val Ala
          35                  40                  45            
 Glu Pro Glu Ala Cys Asp Gln Met Tyr Glu Ser Leu Ala Arg Leu His
      50                  55                  60                
 Ser Asn Tyr Tyr Lys His Lys Tyr Pro Arg Pro Arg Asp Thr Ser Phe
  65                  70                  75                  80
 Ser Gly Leu Ser Leu Glu Glu Tyr Lys Leu Ile Leu Ser Thr Asp Thr
                  85                  90                  95    
 Leu Glu Glu Leu Lys Glu Ile Asp Lys Gly Met Trp Lys Lys Leu Gln
             100                 105                 110        
 Glu Lys Phe Ala Pro Lys Gly Pro Glu Glu Asp His Lys Ala
         115                 120                 125    



      <210> 1009
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 1009
 Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys
   1               5                  10                  15    
 Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val
              20                  25                  30        
 Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr
          35                  40                  45            
 Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr
      50                  55                  60                
 Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp
  65                  70                  75                  80
 Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp
                  85                  90                  95    
 Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg
             100                 105                 110        
 Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg
         115                 120                 125            
 Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr
     130                 135                 140                
 Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys
 145                 150                 155                 160
 Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu
                 165                 170                 175    
 Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala
             180                 185                 190        
 Phe Arg Thr Leu Gly Leu
         195            



      <210> 1010
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 1010
 Met Gln Leu Val Gln Gln Arg Ser Gln Ile Gln Thr Leu Gln Lys Lys
   1               5                  10                  15    
 Val Val Asn Leu Glu Thr Ala Leu Ser Tyr Met Thr Lys Glu Phe Glu
              20                  25                  30        
 Ser Glu Val Leu Lys Leu Gln Gln His Ala Met Ile Glu Asn Gln Ala
          35                  40                  45            
 Gly Gln Val Glu Ile Asp Lys Leu Gln His Leu Leu Gln Met Lys Asp
      50                  55                  60                
 Arg Glu Met Asn Arg Val Lys Lys Leu Ala Lys Asn Ile Leu Asp Glu
  65                  70                  75                  80
 Arg Thr Glu Val Glu Arg Phe Phe Leu Asp Ala Leu His Gln Val Lys
                  85                  90                  95    
 Gln Gln Ile Leu Ile Ser Arg Lys His Tyr Lys Gln Ile Ala Gln Ala
             100                 105                 110        
 Ala Phe Asn Leu Lys Met Arg Ala Ala Cys Thr Gly Arg Thr Glu Tyr
         115                 120                 125            
 Pro Lys Ile Arg Thr Phe Asp Gly Arg Glu His Ser Thr Asn Ser Val
     130                 135                 140                
 Asn Gln Asp Leu Leu Glu Ala Glu Lys Trp Thr His Ile Glu Gly Asn
 145                 150                 155                 160
 Val Asp Ile Gly Asp Leu Thr Trp Glu Gln Lys Glu Lys Val Leu Arg
                 165                 170                 175    
 Leu Leu Phe Ala Lys Met Asn Gly Cys Pro Ser Arg Lys Tyr Asn Gln
             180                 185                 190        
 Ser Ser Arg Pro Pro Val Pro Asp Tyr Val Val Ser Asp Ser Gly Glu
         195                 200                 205            
 Thr Lys Glu Phe Gly Asp Glu Ser Lys Leu Gln Asp Lys Ile Phe Ile
     210                 215                 220                
 Thr Gln Gln Ile Ala Ile Ser Asp Ser Ser Gly Glu Val Val Leu Pro
 225                 230                 235                 240
 Thr Ile Pro Lys Glu Pro Gln Glu Ser Asp Thr Gly Thr Phe
                 245                 250                



      <210> 1011
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 1011
 Met Tyr Lys Leu Leu Gln Ala Cys Ser His Thr Arg Val Cys Thr Ala
   1               5                  10                  15    
 Glu Arg Arg Met Ser Phe Tyr Cys Thr His Ala His Thr His Ala His
              20                  25                  30        
 Val His Ser Leu His Thr Cys Ser Leu Leu His Thr Cys Thr Phe Met
          35                  40                  45            
 Cys Thr Pro Gln Met Ser Ser His Thr Cys Lys His Thr Cys Thr His
      50                  55                  60                
 Arg Thr His Val Ser Ser His Thr Tyr Thr Gln Met His Met Asp Thr
  65                  70                  75                  80
 Pro Gln Thr Arg Thr Gly Ser Tyr Thr His Ala His Thr Cys Thr Pro
                  85                  90                  95    
 Gln Thr Ser Ser Gln Thr Cys Lys His Thr Ser Pro Thr Arg Glu Leu
             100                 105                 110        
 Pro His Met Tyr Thr Cys Thr Cys Thr His His Lys His Met Arg Arg
         115                 120                 125            
 Leu Leu Gln Ala
     130        



      <210> 1012
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 1012
 Met Gln Val Asp Leu Ile Leu Trp Thr Ile His Phe Gln Leu Gly Ser
   1               5                  10                  15    
 Ser Leu Thr Phe Asn Leu Lys His Gln Lys Thr Arg Leu Thr Ala Ala
              20                  25                  30        
 Ser Ala Tyr Arg Gly Leu Phe Phe Ser Cys Asn Lys Lys Asn Arg Ser
          35                  40                  45            
 Gly Gln Arg Pro Ser Ser Gln Gly Leu Ser Phe Phe Leu Ser His Gln
      50                  55                  60                
 Pro Tyr His Val Gly Leu Ser Ser Leu Cys Leu Leu Pro His Asp Gly
  65                  70                  75                  80
 Lys Met Ala Ala Ala Pro Leu Gly Leu Thr Thr Asp Phe
                  85                  90            



      <210> 1013
      <211> 732
      <212> PRT
      <213> Homo sapiens


      <400> 1013
 Met Ala Asp Leu Lys Asn Leu Pro Gly Pro Pro Leu Gly Val Gly Gly
   1               5                  10                  15    
 Ala Leu Tyr Cys Ser Pro Ala Ala Ala Gly Pro Trp Asp Arg Met Gly
              20                  25                  30        
 Ala Met Gly Ser Leu Ala Arg Leu Val Ala Val Thr His Gly Pro Leu
          35                  40                  45            
 Arg Arg Arg Cys Lys Ser Ala Gln Leu Pro Thr Cys Cys Ala Leu Thr
      50                  55                  60                
 Gln Cys Glu Gly Asn Gln Gly Thr Arg Ala Lys Trp Val Gln Thr Ser
  65                  70                  75                  80
 Thr Arg Ile Leu Lys Gly Gln Val Lys Gln Thr Leu Ser Ser His Gln
                  85                  90                  95    
 Pro Arg Pro Leu Asp Ser Thr Lys Met Glu Val Lys Gly Gln Leu Ile
             100                 105                 110        
 Ser Ser Pro Thr Phe Asn Ala Pro Ala Ala Leu Phe Gly Glu Ala Ala
         115                 120                 125            
 Pro Gln Val Lys Ser Glu Arg Leu Arg Gly Leu Leu Asp Arg Gln Arg
     130                 135                 140                
 Thr Leu Gln Glu Ala Leu Ser Leu Lys Leu Gln Glu Leu Arg Lys Val
 145                 150                 155                 160
 Cys Leu Gln Glu Ala Glu Leu Thr Gly Gln Leu Pro Pro Glu Cys Pro
                 165                 170                 175    
 Leu Glu Pro Gly Glu Arg Pro Gln Leu Val Arg Arg Arg Pro Pro Thr
             180                 185                 190        
 Ala Arg Ala Tyr Pro Pro Pro His Pro Asn Gln Ala His His Ser Leu
         195                 200                 205            
 Cys Pro Ala Glu Glu Leu Ala Leu Glu Ala Leu Glu Arg Glu Val Ser
     210                 215                 220                
 Val Gln Gln Gln Ile Ala Ala Ala Ala Arg Arg Leu Ala Leu Ala Pro
 225                 230                 235                 240
 Asp Leu Ser Thr Glu Gln Arg Arg Arg Arg Arg Gln Val Gln Ala Asp
                 245                 250                 255    
 Ala Leu Arg Arg Leu His Glu Leu Glu Glu Gln Leu Arg Asp Val Arg
             260                 265                 270        
 Ala Arg Leu Gly Leu Pro Val Leu Pro Leu Pro Gln Pro Leu Pro Leu
         275                 280                 285            
 Ser Thr Gly Ser Val Ile Thr Thr Gln Gly Val Cys Leu Gly Met Arg
     290                 295                 300                
 Leu Ala Gln Leu Ser Gln Glu Asp Val Val Leu His Ser Glu Ser Ser
 305                 310                 315                 320
 Ser Leu Ser Glu Ser Gly Ala Ser His Asp Asn Glu Glu Pro His Gly
                 325                 330                 335    
 Cys Phe Ser Leu Ala Glu Arg Pro Ser Pro Pro Lys Ala Trp Asp Gln
             340                 345                 350        
 Leu Arg Ala Val Ser Gly Gly Ser Pro Glu Arg Arg Thr Pro Trp Lys
         355                 360                 365            
 Pro Pro Pro Ser Asp Leu Tyr Gly Asp Leu Lys Ser Arg Arg Asn Ser
     370                 375                 380                
 Val Ala Ser Pro Thr Arg Pro Glu Gly Leu His Ser Arg Gln Trp Ser
 385                 390                 395                 400
 Gly Ser Gln Asp Ser Gln Met Gly Phe Pro Arg Ala Asp Pro Ala Ser
                 405                 410                 415    
 Asp Arg Ala Ser Leu Phe Val Ala Arg Thr Arg Arg Ser Asn Ser Ser
             420                 425                 430        
 Glu Ala Leu Leu Val Asp Arg Ala Ala Gly Gly Gly Ala Gly Ser Pro
         435                 440                 445            
 Pro Ala Pro Leu Ala Pro Ser Ala Ser Gly Pro Pro Val Cys Lys Ser
     450                 455                 460                
 Ser Glu Val Leu Tyr Glu Arg Pro Gln Pro Thr Pro Ala Phe Ser Ser
 465                 470                 475                 480
 Arg Thr Ala Gly Pro Pro Asp Pro Pro Arg Ala Ala Arg Pro Ser Ser
                 485                 490                 495    
 Ala Ala Pro Ala Ser Arg Gly Ala Pro Arg Leu Pro Pro Val Cys Gly
             500                 505                 510        
 Asp Phe Leu Leu Asp Tyr Ser Leu Asp Arg Gly Leu Pro Arg Ser Gly
         515                 520                 525            
 Gly Gly Thr Gly Trp Gly Glu Leu Pro Pro Ala Ala Glu Val Pro Gly
     530                 535                 540                
 Pro Leu Ser Arg Arg Asp Gly Leu Leu Thr Met Leu Pro Gly Pro Pro
 545                 550                 555                 560
 Pro Val Tyr Ala Ala Asp Ser Asn Ser Pro Leu Leu Arg Thr Lys Asp
                 565                 570                 575    
 Pro His Thr Arg Ala Thr Arg Thr Lys Pro Cys Gly Leu Pro Pro Glu
             580                 585                 590        
 Ala Ala Glu Gly Pro Glu Val His Pro Asn Pro Leu Leu Trp Met Pro
         595                 600                 605            
 Pro Pro Thr Arg Ile Pro Ser Ala Gly Glu Arg Ser Gly His Lys Asn
     610                 615                 620                
 Leu Ala Leu Glu Gly Leu Arg Asp Trp Tyr Ile Arg Asn Ser Gly Leu
 625                 630                 635                 640
 Ala Ala Gly Pro Gln Arg Arg Pro Val Leu Pro Ser Val Gly Pro Pro
                 645                 650                 655    
 His Pro Pro Phe Leu His Ala Arg Cys Tyr Glu Val Gly Gln Ala Leu
             660                 665                 670        
 Tyr Gly Ala Pro Ser Gln Ala Pro Leu Pro His Ser Arg Ser Phe Thr
         675                 680                 685            
 Ala Pro Pro Val Ser Gly Arg Tyr Tyr Ala Asp Phe Leu Tyr Pro Pro
     690                 695                 700                
 Glu Leu Ser Ala Arg Leu Ser Asp Leu Thr Leu Glu Gly Glu Gln Ser
 705                 710                 715                 720
 Ser Ser Ser Asp Thr Gln Thr Pro Gly Thr Leu Val
                 725                 730        



      <210> 1014
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 1014
 Met Trp Thr Ser Ala Pro Arg Leu Lys Ser Ala Asp Trp Leu Met Lys
   1               5                  10                  15    
 Thr Cys Val Leu Arg Gln Arg Lys Gly Ser Ser Arg Lys Gln Arg Leu
              20                  25                  30        
 Leu Ser Trp Ala Trp Gln Gln Gly Arg Gly Gln Val Val Glu Ile Leu
          35                  40                  45            
 Gln Ser Glu Lys Gln Thr Glu Arg
      50                  55    



      <210> 1015
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 1015
 Met Val Leu Ser Leu Asp Thr Pro Thr Ser Tyr Leu Gln Phe Ser Arg
   1               5                  10                  15    
 Arg Arg Ala Ser Gly Thr Leu Gly Cys Lys Pro Asn Leu Gly Ser Met
              20                  25                  30        
 Phe Ala Leu Asn Pro Asn Ser Gln Arg Arg Ser Glu Cys Ile Phe His
          35                  40                  45            
 His Ala Ala Ala Gly Cys Trp Pro Arg Phe Cys Val Phe Ser Gln Pro
      50                  55                  60                
 Ser Glu Ile Thr Ser Phe Leu Val Ala Val Thr Asn Ser Ser Trp Thr
  65                  70                  75                  80
 Thr Met Lys Leu Ile Tyr Phe Pro Ile
                  85                



      <210> 1016
      <211> 268
      <212> PRT
      <213> Homo sapiens


      <400> 1016
 Met Ala Ala Ile Arg Met Gly Lys Leu Thr Thr Met Pro Ala Gly Leu
   1               5                  10                  15    
 Ile Tyr Ala Ser Val Ser Val His Ala Ala Lys Gln Glu Glu Ser Lys
              20                  25                  30        
 Lys Gln Leu Val Lys Pro Glu Gln Leu Pro Ile Tyr Thr Ala Pro Pro
          35                  40                  45            
 Leu Gln Ser Lys Tyr Val Glu Glu Gln Pro Gly His Leu Gln Met Gly
      50                  55                  60                
 Phe Ala Ser Ile Arg Thr Ala Thr Gly Cys Tyr Ile Gly Trp Cys Lys
  65                  70                  75                  80
 Gly Val Tyr Val Phe Val Lys Asn Gly Ile Met Asp Thr Val Gln Phe
                  85                  90                  95    
 Gly Lys Asp Ala Tyr Val Tyr Leu Lys Asn Pro Pro Arg Asp Phe Leu
             100                 105                 110        
 Pro Lys Met Gly Val Ile Thr Val Ser Gly Leu Ala Gly Leu Val Ser
         115                 120                 125            
 Ala Arg Lys Gly Ser Lys Phe Lys Lys Ile Thr Tyr Pro Leu Gly Leu
     130                 135                 140                
 Ala Thr Leu Gly Ala Thr Val Cys Tyr Pro Val Gln Ser Val Ile Ile
 145                 150                 155                 160
 Ala Lys Val Thr Ala Lys Lys Val Tyr Ala Thr Ser Gln Gln Ile Phe
                 165                 170                 175    
 Gly Ala Val Lys Ser Leu Trp Thr Lys Ser Ser Lys Glu Glu Ser Leu
             180                 185                 190        
 Pro Lys Pro Lys Glu Lys Thr Lys Leu Gly Ser Ser Ser Glu Ile Glu
         195                 200                 205            
 Val Pro Ala Lys Thr Thr His Val Leu Lys His Ser Val Pro Leu Pro
     210                 215                 220                
 Thr Glu Leu Ser Ser Glu Ala Lys Thr Lys Ser Glu Ser Thr Ser Gly
 225                 230                 235                 240
 Ala Thr Gln Phe Met Pro Asp Pro Lys Leu Met Asp His Gly Gln Ser
                 245                 250                 255    
 His Pro Glu Asp Ile Asp Met Tyr Ser Thr Arg Ser
             260                 265            



      <210> 1017
      <211> 82
      <212> PRT
      <213> Homo sapiens


      <400> 1017
 Met Gly Ile Glu Ile Ile Thr Arg Arg Gln Phe Lys Lys Phe Tyr Pro
   1               5                  10                  15    
 Leu Ala Asn Tyr Glu Thr His Ser Leu Ile Thr Leu Glu Ser Lys Arg
              20                  25                  30        
 Lys Pro Lys Lys Ile Leu Thr Ser Ser Leu Pro Phe Ser Leu Glu Val
          35                  40                  45            
 Lys Val Ile Arg Lys Lys Arg Gln Lys Asn Ile Ser Leu Ser Gln Leu
      50                  55                  60                
 Leu Ser Thr Val Lys Glu Glu Ile Phe Tyr Ser Leu Leu Lys Asn Lys
  65                  70                  75                  80
 Glu Lys
        



      <210> 1018
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 1018
 Met Ser Cys Cys Tyr Gln Tyr Phe Phe Pro His Phe Pro Leu Ile Phe
   1               5                  10                  15    
 Val Met Leu Glu Lys Ser Lys Leu His Leu Asp Thr Phe Asn Phe Met
              20                  25                  30        
 Pro Phe Ser Leu Tyr Leu Pro Leu Phe Leu Gly Thr Leu Ala His Phe
          35                  40                  45            
 Val Thr Val Lys Asp Tyr Cys Pro Val Thr Ser Leu Ile Arg Asn Leu
      50                  55                  60                
 Asn Cys Ile His Ser Glu Cys Phe Lys Leu Ser His Lys Leu His Leu
  65                  70                  75                  80
 Pro Met Asp Leu Trp Leu Phe Cys
                  85            



      <210> 1019
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 1019
 Met Thr Asp Met Leu Lys Glu Glu Glu Glu Arg Leu Gln Leu Ala His
   1               5                  10                  15    
 Ser Asn Met Thr Lys Gly Gln Glu Leu Leu Leu Thr Ile Gln Met Gly
              20                  25                  30        
 Ile Asp Asn Leu Tyr Val Arg Leu Met Gly Ile Thr Leu Pro Ala Thr
          35                  40                  45            
 Gln Val Pro Gly Val Arg Leu Ser Cys His Thr Pro Gly Pro Trp Ala
      50                  55                  60                
 Gly Pro Glu Gly Arg
  65                



      <210> 1020
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 1020
 Met Gly Glu Leu Ala Ile Cys His Thr Arg Val Pro Phe Ser Leu Pro
   1               5                  10                  15    
 Ser Ser Ala Gln Gly Val Pro Gln Asn Leu Gln Gly Pro Ile Gly His
              20                  25                  30        
 Leu Ala Val Cys Thr Pro Ser Ser Leu Thr Ser Trp His Phe Pro Gln
          35                  40                  45            
 Lys Arg Glu Lys Trp Ser Thr Val Asn Lys Arg Gln Arg Phe Leu Gln
      50                  55                  60                
 Phe Pro Ala Pro Leu Arg Asn Trp Ile Pro Gln Thr Pro Leu Ser Leu
  65                  70                  75                  80
 Ser Val Ser Ser Gly Pro Leu Gly Ser Phe Thr Val Phe Thr Leu Leu
                  85                  90                  95    
 Ser Leu Cys Ala Trp Pro Trp Cys Cys Arg Asp Cys Tyr Lys Ser Cys
             100                 105                 110        
 Cys Pro Ile Pro Ile Phe Asn Leu Thr Ala Pro Leu Cys Val His Thr
         115                 120                 125            
 Pro Glu Pro Ser Ser
     130            



      <210> 1021
      <211> 388
      <212> PRT
      <213> Homo sapiens


      <400> 1021
 Met Val Glu Ala Glu Glu Leu Ala Gln Leu Arg Leu Leu Asn Leu Glu
   1               5                  10                  15    
 Leu Leu Arg Gln Leu Trp Val Gly Gln Asp Ala Val Arg Arg Ser Val
              20                  25                  30        
 Ala Arg Ala Ala Ser Glu Ser Ser Leu Glu Ser Ser Ser Ser Tyr Asn
          35                  40                  45            
 Ser Glu Thr Pro Ser Thr Pro Glu Thr Ser Ser Thr Ser Leu Ser Thr
      50                  55                  60                
 Ser Cys Pro Arg Gly Arg Ser Ser Val Trp Gly Pro Pro Asp Ala Cys
  65                  70                  75                  80
 Arg Gly Asp Leu Arg Asp Val Ala Arg Ser Gly Val Ala Ser Leu Pro
                  85                  90                  95    
 Pro Ala Asn Cys Gln His Gln Glu Ser Leu Gly Arg Pro Arg Pro His
             100                 105                 110        
 Ser Ala Pro Ser Leu Gly Thr Ser Ser Leu Arg Asp Pro Glu Pro Ser
         115                 120                 125            
 Gly Arg Leu Gly Asp Pro Gly Pro Gln Glu Ala Gln Thr Pro Arg Ser
     130                 135                 140                
 Ile Leu Ala Gln Gln Ser Lys Leu Ser Lys Pro Arg Val Thr Phe Ser
 145                 150                 155                 160
 Glu Glu Ser Ala Val Pro Lys Arg Ser Trp Arg Leu Arg Pro Tyr Leu
                 165                 170                 175    
 Gly Tyr Asp Trp Ile Ala Gly Ser Leu Asp Thr Ser Ser Ser Ile Thr
             180                 185                 190        
 Ser Gln Pro Glu Ala Phe Phe Ser Lys Leu Gln Glu Phe Arg Glu Thr
         195                 200                 205            
 Asn Lys Glu Glu Cys Ile Cys Ser His Pro Glu Pro Gln Leu Pro Gly
     210                 215                 220                
 Leu Arg Glu Ser Ser Gly Ser Gly Val Glu Glu Asp His Glu Cys Val
 225                 230                 235                 240
 Tyr Cys Tyr Arg Val Asn Arg Arg Leu Phe Pro Val Pro Val Asp Pro
                 245                 250                 255    
 Gly Thr Pro Cys Arg Leu Cys Arg Thr Pro Arg Asp Gln Gln Gly Pro
             260                 265                 270        
 Gly Thr Leu Ala Gln Pro Ala His Val Arg Val Ser Ile Pro Leu Ser
         275                 280                 285            
 Ile Leu Glu Pro Pro His Arg Tyr His Ile His Arg Arg Lys Ser Phe
     290                 295                 300                
 Asp Ala Ser Asp Thr Leu Ala Leu Pro Arg His Cys Leu Leu Gly Trp
 305                 310                 315                 320
 Asp Ile Phe Pro Pro Lys Ser Glu Lys Ser Ser Ala Pro Arg Asn Leu
                 325                 330                 335    
 Asp Leu Trp Ser Ser Val Ser Ala Glu Ala Gln His Gln Lys Leu Ser
             340                 345                 350        
 Gly Thr Ser Ser Pro Phe His Pro Ala Ser Pro Met Gln Met Leu Pro
         355                 360                 365            
 Pro Thr Pro Thr Trp Ser Val Pro Gln Val Pro Arg Pro His Val Pro
     370                 375                 380                
 Arg Gln Lys Pro
 385            



      <210> 1022
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 1022
 Met Gly Gln Gln Pro Gly Lys Val Leu Gly Asp Gln Arg Arg Pro Ser
   1               5                  10                  15    
 Leu Pro Ala Leu His Phe Ile Lys Gly Ala Gly Lys Lys Glu Ser Ser
              20                  25                  30        
 Arg His Gly Gly Pro His Cys Asn Val Phe Val Glu His Gly Glu Cys
          35                  40                  45            
 Phe Ser Lys Phe Leu Leu Met Val Phe Leu Met His Ser Ser
      50                  55                  60        



      <210> 1023
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 1023
 Met Glu Asn His His Ser Pro Lys Gly Gln Arg Arg Phe Gln Arg Lys
   1               5                  10                  15    
 Gly Val Ile Gly Ala Val Phe Cys Arg Met Ser Gln Ser Ser Pro Ser
              20                  25                  30        
 Arg Gln Gly Lys Glu Gly Cys Cys Arg Glu Gly Thr Ala Tyr Ala Lys
          35                  40                  45            
 Ala Tyr Gln Phe Met Ala Ser His Leu Ser Leu Gly Lys Pro Val Ser
      50                  55                  60                
 Thr Gly Ser Ile Pro Arg Phe Asn Lys Ala Leu Phe Asn Lys Gln Ala
  65                  70                  75                  80
 Lys Cys Lys Pro Asn His Tyr Ser Phe Ile Gly Leu Ser Met Leu Ser
                  85                  90                  95    
 Pro Glu Asn Phe Ser Ile Gly Cys Lys Tyr Ser Val Trp Phe Ser Glu
             100                 105                 110        
 Ser Lys Gly Phe
         115    



      <210> 1024
      <211> 240
      <212> PRT
      <213> Homo sapiens


      <400> 1024
 Met Glu Gln Thr Trp Thr Arg Asp Tyr Phe Ala Glu Gly Asp Gly Glu
   1               5                  10                  15    
 Met Val Pro Arg Thr Ser His Thr Ala Ala Phe Leu Ser Asp Thr Lys
              20                  25                  30        
 Asp Arg Gly Pro Pro Val Gln Ser Gln Ile Trp Arg Ser Gly Glu Lys
          35                  40                  45            
 Val Pro Phe Val Gln Thr Tyr Ser Leu Arg Ala Phe Glu Lys Pro Pro
      50                  55                  60                
 Gln Val Gln Thr Gln Ala Leu Arg Asp Phe Glu Lys His Leu Asn Asp
  65                  70                  75                  80
 Leu Lys Lys Glu Asn Phe Ser Leu Lys Leu Arg Ile Tyr Phe Leu Glu
                  85                  90                  95    
 Glu Arg Met Gln Gln Lys Tyr Glu Ala Ser Arg Glu Asp Ile Tyr Lys
             100                 105                 110        
 Arg Asn Thr Glu Leu Lys Val Glu Val Glu Ser Leu Lys Arg Glu Leu
         115                 120                 125            
 Gln Asp Lys Lys Gln His Leu Asp Lys Thr Trp Ala Asp Val Glu Asn
     130                 135                 140                
 Leu Asn Ser Gln Asn Glu Ala Glu Leu Arg Arg Gln Phe Glu Glu Arg
 145                 150                 155                 160
 Gln Gln Glu Thr Glu His Val Tyr Glu Leu Leu Glu Asn Lys Met Gln
                 165                 170                 175    
 Leu Leu Gln Glu Glu Ser Arg Leu Ala Lys Asn Glu Ala Ala Arg Met
             180                 185                 190        
 Ala Ala Leu Val Glu Ala Glu Lys Glu Cys Asn Leu Glu Leu Ser Glu
         195                 200                 205            
 Lys Leu Lys Gly Val Thr Lys Asn Trp Glu Asp Val Pro Gly Asp Gln
     210                 215                 220                
 Val Lys Pro Asp Gln Tyr Thr Glu Ala Leu Ala Gln Arg Asp Lys Ile
 225                 230                 235                 240





      <210> 1025
      <211> 73
      <212> PRT
      <213> Homo sapiens


      <400> 1025
 Met Ala Leu Thr Ser Thr Asp His Asn Thr Lys Pro Thr Met Ile Arg
   1               5                  10                  15    
 Arg Pro Pro Ala Val Val Cys Tyr Ile Cys Gly Arg Glu Tyr Gly Thr
              20                  25                  30        
 Lys Ser Ile Ser Ile His Glu Pro Gln Cys Leu Lys Lys Trp His Asn
          35                  40                  45            
 Glu Asn Asn Leu Leu Pro Lys Glu Leu Arg Arg Pro Val Pro Lys Lys
      50                  55                  60                
 Pro Glu Val Arg Thr Ile Thr Asp Lys
  65                  70            



      <210> 1026
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 1026
 Met Lys Ile Phe Tyr Tyr Ala Leu Asn Leu Glu Leu Tyr Lys Thr Cys
   1               5                  10                  15    
 Thr Lys Ile Val Gln Asp Lys Phe His Leu Val Met Ser Phe Pro Asn
              20                  25                  30        
 Thr Gly Leu Arg Leu His Trp Thr Leu Gly Ile Cys Thr Lys Ile Ile
          35                  40                  45            
 Ser Arg Ser Gln Met Ser Leu Val His Lys His Tyr His Phe Lys Tyr
      50                  55                  60                
 Tyr Tyr Leu Leu Pro Gln Gln Leu Tyr Ile Ser Ile Ala Phe Gly Trp
  65                  70                  75                  80
 Gly Arg Gly Thr Phe Leu Leu Gln Leu Glu Ile Ala Leu Leu Val Ser
                  85                  90                  95    
 Tyr Leu Phe Val Val Phe Lys Lys Tyr Ile Val Val Arg Val Ile Phe
             100                 105                 110        
 Ser Ile Tyr Phe Ile Pro Gly Gly Asp His Ala Thr Leu Ser Lys Glu
         115                 120                 125            
 Asn
    



      <210> 1027
      <211> 425
      <212> PRT
      <213> Homo sapiens


      <400> 1027
 Met Leu Arg Lys Ile Leu Ala Ser Gln Gln Pro Asp Arg Cys Lys Arg
   1               5                  10                  15    
 Ala Gln Ala Phe Ile Ser Thr Gln Gly Leu Lys Pro Asp Thr Val Ala
              20                  25                  30        
 Glu Leu Val Ala Glu Glu Val Thr Arg Glu Leu Leu Thr Ser Ser Gln
          35                  40                  45            
 Gly Thr Gly His Lys Gln Met Phe Asn Pro Thr Glu Glu Ser Gln Thr
      50                  55                  60                
 Phe Leu Gln Leu Thr Thr Leu Cys Gln Asp Arg Thr Leu Val Gly Met
  65                  70                  75                  80
 Lys Leu Leu Asp Lys Ile Ser Ser Val Pro His Gly Glu Leu Ser Cys
                  85                  90                  95    
 Thr Thr Glu Leu Leu Ile Leu Ala His His Cys Phe Thr Leu Thr Cys
             100                 105                 110        
 His Met Glu Gly Ile Ile Arg Val Leu Gln Ala Ala His Met Leu Thr
         115                 120                 125            
 Asp Asn His Leu Ala Pro Ser Glu Glu Tyr Gly Leu Val Val Arg Leu
     130                 135                 140                
 Leu Thr Gly Ile Gly Arg Tyr Asn Glu Met Thr Tyr Ile Phe Asp Leu
 145                 150                 155                 160
 Leu His Lys Lys His Tyr Phe Glu Val Leu Met Arg Lys Lys Leu Asp
                 165                 170                 175    
 Pro Ser Gly Thr Leu Lys Thr Ala Leu Leu Asp Tyr Ile Lys Arg Cys
             180                 185                 190        
 Arg Pro Gly Asp Ser Glu Lys His Asn Met Ile Ala Leu Cys Phe Ser
         195                 200                 205            
 Met Cys Arg Glu Ile Gly Glu Asn His Glu Ala Ala Ala Arg Ile Gln
     210                 215                 220                
 Leu Lys Leu Ile Glu Ser Gln Pro Trp Glu Asp Ser Leu Lys Asp Gly
 225                 230                 235                 240
 His Gln Leu Lys Gln Leu Leu Leu Lys Ala Leu Thr Leu Met Leu Asp
                 245                 250                 255    
 Ala Ala Glu Ser Tyr Ala Lys Asp Ser Cys Val Arg Gln Ala Gln His
             260                 265                 270        
 Cys Gln Arg Leu Thr Lys Leu Ile Thr Leu Gln Ile His Phe Leu Asn
         275                 280                 285            
 Thr Gly Gln Asn Thr Met Leu Ile Asn Leu Gly Arg His Lys Leu Met
     290                 295                 300                
 Asp Cys Ile Leu Ala Leu Pro Arg Phe Tyr Gln Ala Ser Ile Val Ala
 305                 310                 315                 320
 Glu Ala Tyr Asp Phe Val Pro Asp Trp Ala Glu Ile Leu Tyr Gln Gln
                 325                 330                 335    
 Val Ile Leu Lys Gly Asp Phe Asn Tyr Leu Glu Glu Phe Lys Gln Gln
             340                 345                 350        
 Arg Leu Leu Lys Ser Ser Ile Phe Glu Glu Ile Ser Lys Lys Tyr Lys
         355                 360                 365            
 Gln His Gln Pro Thr Asp Met Val Met Glu Asn Leu Lys Lys Leu Leu
     370                 375                 380                
 Thr Tyr Cys Glu Asp Val Tyr Leu Tyr Tyr Lys Leu Ala Tyr Glu His
 385                 390                 395                 400
 Lys Phe Tyr Glu Ile Val Asn Val Leu Leu Lys Asp Pro Gln Thr Gly
                 405                 410                 415    
 Cys Cys Leu Lys Asp Met Leu Ala Gly
             420                 425



      <210> 1028
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 1028
 Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn
   1               5                  10                  15    
 Asp Gly Val Leu Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val
              20                  25                  30        
 Pro His Val Phe Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe Ile Gly
          35                  40                  45            
 Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Thr Trp Leu
      50                  55                  60                
 His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Thr Phe Ala Leu Leu
  65                  70                  75                  80
 Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg
                  85                  90                  95    
 Arg Glu Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe
             100                 105                 110        
 Val Ala Thr Thr Thr Ser Ile Val Tyr Tyr His Asn Ile Glu Thr Ser
         115                 120                 125            
 Asn Phe Pro Lys Leu Leu Leu Gly Phe Ser His His Glu Ser Lys Ser
     130                 135                 140                
 Cys Tyr Gln His Ser
 145                



      <210> 1029
      <211> 763
      <212> PRT
      <213> Homo sapiens


      <400> 1029
 Met Glu His His Leu Gln Arg Ala Ile Ser Ala Gln Gln Val Tyr Gly
   1               5                  10                  15    
 Glu Lys Arg Asp Asn Met Val Ile Pro Val Pro Glu Ala Glu Ser Asn
              20                  25                  30        
 Ile Ala Tyr Tyr Glu Ser Ile Tyr Pro Gly Glu Phe Lys Met Pro Lys
          35                  40                  45            
 Gln Leu Ile His Ile Gln Pro Phe Ser Leu Asp Ala Glu Gln Pro Asp
      50                  55                  60                
 Tyr Asp Leu Asp Ser Glu Asp Glu Val Phe Val Asn Lys Leu Lys Lys
  65                  70                  75                  80
 Lys Met Asp Ile Cys Pro Leu Gln Phe Glu Glu Met Ile Asp Arg Leu
                  85                  90                  95    
 Glu Lys Gly Ser Gly Gln Gln Pro Val Ser Leu Gln Glu Ala Lys Leu
             100                 105                 110        
 Leu Leu Lys Glu Asp Asp Glu Leu Ile Arg Glu Val Tyr Glu Tyr Trp
         115                 120                 125            
 Ile Lys Lys Arg Lys Asn Cys Arg Gly Pro Ser Leu Ile Pro Ser Val
     130                 135                 140                
 Lys Gln Glu Lys Arg Asp Gly Ser Ser Thr Asn Asp Pro Tyr Val Ala
 145                 150                 155                 160
 Phe Arg Arg Arg Thr Glu Lys Met Gln Thr Arg Lys Asn Arg Lys Asn
                 165                 170                 175    
 Asp Glu Ala Ser Tyr Glu Lys Met Leu Lys Leu Arg Arg Asp Leu Ser
             180                 185                 190        
 Arg Ala Val Thr Ile Leu Glu Met Ile Lys Arg Arg Glu Lys Ser Lys
         195                 200                 205            
 Arg Glu Leu Leu His Leu Thr Leu Glu Ile Met Glu Lys Arg Tyr Asn
     210                 215                 220                
 Leu Gly Asp Tyr Asn Gly Glu Ile Met Ser Glu Val Met Ala Gln Arg
 225                 230                 235                 240
 Gln Pro Met Lys Pro Thr Tyr Ala Ile Pro Ile Ile Pro Ile Thr Asn
                 245                 250                 255    
 Ser Ser Gln Phe Lys His Gln Glu Ala Met Asp Val Lys Glu Phe Lys
             260                 265                 270        
 Val Asn Lys Gln Asp Lys Ala Asp Leu Ile Arg Pro Lys Arg Lys Tyr
         275                 280                 285            
 Glu Lys Lys Pro Lys Val Leu Pro Ser Ser Ala Ala Ala Thr Pro Gln
     290                 295                 300                
 Gln Thr Ser Pro Ala Ala Leu Pro Val Phe Asn Ala Lys Asp Leu Asn
 305                 310                 315                 320
 Gln Tyr Asp Phe Pro Ser Ser Asp Glu Glu Pro Leu Ser Gln Val Leu
                 325                 330                 335    
 Ser Gly Ser Ser Glu Ala Glu Glu Asp Asn Asp Pro Asp Gly Pro Phe
             340                 345                 350        
 Ala Phe Arg Arg Lys Ala Gly Cys Gln Tyr Tyr Ala Pro His Leu Asp
         355                 360                 365            
 Gln Thr Gly Asn Trp Pro Trp Thr Ser Pro Lys Asp Gly Gly Leu Gly
     370                 375                 380                
 Asp Val Arg Tyr Arg Tyr Cys Leu Thr Thr Leu Thr Val Pro Gln Arg
 385                 390                 395                 400
 Cys Ile Gly Phe Ala Arg Arg Arg Val Gly Arg Gly Gly Arg Val Leu
                 405                 410                 415    
 Leu Asp Arg Ala His Ser Asp Tyr Asp Ser Val Phe His His Leu Asp
             420                 425                 430        
 Leu Glu Met Leu Ser Ser Pro Gln His Ser Pro Val Asn Gln Phe Ala
         435                 440                 445            
 Asn Thr Ser Glu Thr Asn Thr Ser Asp Lys Ser Phe Ser Lys Asp Leu
     450                 455                 460                
 Ser Gln Ile Leu Val Asn Ile Lys Ser Cys Arg Trp Arg His Phe Arg
 465                 470                 475                 480
 Pro Arg Thr Pro Ser Leu His Asp Ser Asp Asn Asp Glu Leu Ser Cys
                 485                 490                 495    
 Arg Lys Leu Tyr Arg Ser Ile Asn Arg Thr Gly Thr Ala Gln Pro Gly
             500                 505                 510        
 Thr Gln Thr Cys Ser Thr Ser Thr Gln Ser Lys Ser Ser Ser Gly Ser
         515                 520                 525            
 Ala His Phe Ala Phe Thr Ala Glu Gln Tyr Gln Gln His Gln Gln Gln
     530                 535                 540                
 Leu Ala Leu Met Gln Lys Gln Gln Leu Ala Gln Ile Gln Gln Gln Gln
 545                 550                 555                 560
 Ala Asn Ser Asn Ser Ser Thr Asn Thr Ser Gln Gly Phe Val Ser Lys
                 565                 570                 575    
 Thr Leu Asp Ser Ala Ser Ala Gln Phe Ala Ala Ser Ala Leu Val Thr
             580                 585                 590        
 Ser Glu Gln Leu Met Gly Phe Lys Met Lys Asp Asp Val Val Leu Gly
         595                 600                 605            
 Ile Gly Val Asn Gly Val Leu Pro Ala Ser Gly Val Tyr Lys Gly Leu
     610                 615                 620                
 His Leu Ser Ser Thr Thr Pro Thr Ala Leu Val His Thr Ser Pro Ser
 625                 630                 635                 640
 Thr Ala Gly Ser Ala Leu Leu Gln Pro Ser Asn Ile Thr Gln Thr Ser
                 645                 650                 655    
 Ser Ser His Ser Ala Leu Ser His Gln Val Thr Ala Ala Asn Ser Ala
             660                 665                 670        
 Thr Thr Gln Val Leu Ile Gly Asn Asn Ile Arg Leu Thr Val Pro Ser
         675                 680                 685            
 Ser Val Ala Thr Val Asn Ser Ile Ala Pro Ile Asn Ala Arg His Ile
     690                 695                 700                
 Pro Arg Thr Leu Ser Ala Val Pro Ser Ser Ala Leu Lys Leu Ala Ala
 705                 710                 715                 720
 Ala Ala Asn Cys Gln Val Ser Lys Val Pro Ser Ser Ser Ser Val Asp
                 725                 730                 735    
 Ser Val Pro Arg Glu Asn His Glu Ser Glu Lys Pro Ala Leu Asn Asn
             740                 745                 750        
 Ile Ala Asp Asn Thr Val Ala Met Glu Val Thr
         755                 760            



      <210> 1030
      <211> 70
      <212> PRT
      <213> Homo sapiens


      <400> 1030
 Met Ile Leu Pro Thr Lys Ala Met Ala Thr Gln Glu Leu Thr Val Lys
   1               5                  10                  15    
 Arg Lys Leu Ser Gly Asn Thr Leu Gln Val Gln Ala Ser Ser Pro Val
              20                  25                  30        
 Ala Leu Gly Val Arg Ile Pro Thr Val Ala Leu His Met Met Glu Leu
          35                  40                  45            
 Phe Asp Thr Thr Val Glu Gln Leu Tyr Ser Ile Phe Thr Val Lys Glu
      50                  55                  60                
 Val Ser Asn Ser Leu Ser
  65                  70



      <210> 1031
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 1031
 Met Gln Thr Ser Glu Arg Glu Gly Ser Gly Pro Glu Leu Ser Pro Ser
   1               5                  10                  15    
 Val Met Pro Glu Ala Pro Leu Glu Ser Pro Pro Phe Pro Thr Lys Ser
              20                  25                  30        
 Pro Ala Phe Asp Leu Phe Asn Leu Val Leu Ser Tyr Lys Arg Leu Glu
          35                  40                  45            
 Ile Tyr Leu Glu Pro Leu Lys Asp Ala Gly Asp Gly Val Arg Tyr Leu
      50                  55                  60                
 Leu Arg Tyr Arg Leu Cys Gly Val Ala Leu Val Cys Ser Ala Phe Cys
  65                  70                  75                  80
 Arg Pro Ala Leu
                



      <210> 1032
      <211> 98
      <212> PRT
      <213> Homo sapiens


      <400> 1032
 Met Gln Thr Ser Glu Arg Glu Gly Ser Gly Pro Glu Leu Ser Pro Ser
   1               5                  10                  15    
 Val Met Pro Glu Ala Pro Leu Glu Ser Pro Pro Phe Pro Thr Lys Ser
              20                  25                  30        
 Pro Ala Phe Asp Leu Phe Asn Leu Val Leu Ser Tyr Lys Arg Leu Glu
          35                  40                  45            
 Ile Tyr Leu Glu Pro Leu Lys Asp Ala Gly Asp Gly Val Arg Tyr Leu
      50                  55                  60                
 Leu Arg Cys Met Val Leu Ser Arg Cys Pro Asp Asp Phe Ser Ala Arg
  65                  70                  75                  80
 Pro Ala Gly Leu Pro Ser Gly Gly Leu Pro Gly Thr Ala Ala Leu Ile
                  85                  90                  95    
 Pro Asn
        



      <210> 1033
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 1033
 Met Ala Leu Pro Val Ser Arg Ala Leu Gln Cys Gln Arg Phe Gly Ala
   1               5                  10                  15    
 Leu Pro Val Glu Met Glu Arg Leu Val Leu Ser Leu Trp Ser Leu Thr
              20                  25                  30        
 Cys Arg Ala Ser Pro Ala Asn Thr His Pro Arg Thr Thr Ser Arg Thr
          35                  40                  45            
 Arg Thr Leu Asp Val Lys Thr Lys Cys Pro Val Glu Ala Val Lys Leu
      50                  55                  60                
 Ser Glu Met Leu Pro Pro Val
  65                  70    



      <210> 1034
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 1034
 Met Ser Glu Trp Met Lys Lys Gly Pro Leu Glu Trp Gln Asp Tyr Ile
   1               5                  10                  15    
 Tyr Lys Glu Val Arg Val Thr Ala Ser Glu Lys Asn Glu Tyr Lys Gly
              20                  25                  30        
 Trp Val Leu Thr Thr Asp Pro Val Ser Ala Asn Ile Val Leu Val Asn
          35                  40                  45            
 Phe Leu Glu Asp Gly Ser Met Ser Val Thr Gly Ile Met Gly His Ala
      50                  55                  60                
 Val Gln Thr Val Glu Thr Met Asn Glu Gly Asp His Arg Val Arg Glu
  65                  70                  75                  80
 Lys Leu Met His Leu Phe Thr Ser Gly Asp Cys Lys Ala Tyr Ser Pro
                  85                  90                  95    
 Glu Asp Leu Glu Glu Arg Lys Asn Ser Leu Lys Lys Trp Leu Glu Lys
             100                 105                 110        
 Asn His Ile Pro Ile Thr Glu Gln Gly Asp Ala Pro Arg Thr Leu Cys
         115                 120                 125            
 Val Ala Gly Val Leu Thr Ile Asp Pro Pro Tyr Gly Pro Glu Asn Cys
     130                 135                 140                
 Ser Ser Ser Asn Glu Ile Ile Leu Ser Arg Val Gln Asp Leu Ile Glu
 145                 150                 155                 160
 Gly His Leu Thr Ala Ser Gln
                 165        



      <210> 1035
      <211> 287
      <212> PRT
      <213> Homo sapiens


      <400> 1035
 Met Ala Ala Ala Ala Val Asn Gly Ala Ala Gly Phe Ser Ser Ser Gly
   1               5                  10                  15    
 Pro Ala Ala Thr Ser Gly Ala Val Leu Gln Ala Ala Thr Gly Met Tyr
              20                  25                  30        
 Glu Gln Leu Lys Gly Glu Trp Asn Arg Lys Ser Pro Asn Leu Ser Lys
          35                  40                  45            
 Cys Gly Glu Glu Leu Gly Arg Leu Lys Leu Val Leu Leu Glu Leu Asn
      50                  55                  60                
 Phe Leu Pro Thr Thr Gly Thr Lys Leu Thr Lys Gln Gln Leu Ile Leu
  65                  70                  75                  80
 Ala Arg Asp Ile Leu Glu Ile Gly Ala Gln Trp Ser Ile Leu Arg Lys
                  85                  90                  95    
 Asp Ile Pro Ser Phe Glu Arg Tyr Met Ala Gln Leu Lys Cys Tyr Tyr
             100                 105                 110        
 Phe Asp Tyr Lys Glu Gln Leu Pro Glu Ser Ala Tyr Met His Gln Leu
         115                 120                 125            
 Leu Gly Leu Asn Leu Leu Phe Leu Leu Ser Gln Asn Arg Val Ala Glu
     130                 135                 140                
 Phe His Thr Glu Leu Glu Arg Leu Pro Ala Lys Asp Ile Gln Thr Asn
 145                 150                 155                 160
 Val Tyr Ile Lys His Pro Val Ser Leu Glu Gln Tyr Leu Met Glu Gly
                 165                 170                 175    
 Ser Tyr Asn Lys Val Phe Leu Ala Lys Gly Asn Ile Pro Ala Glu Ser
             180                 185                 190        
 Tyr Thr Phe Phe Ile Asp Ile Leu Leu Asp Thr Ile Arg Asp Glu Ile
         195                 200                 205            
 Ala Gly Cys Ile Glu Lys Ala Tyr Glu Lys Ile Leu Phe Thr Glu Ala
     210                 215                 220                
 Thr Arg Ile Leu Phe Phe Asn Thr Pro Lys Lys Met Thr Asp Tyr Ala
 225                 230                 235                 240
 Lys Lys Arg Gly Trp Val Leu Gly Pro Asn Asn Tyr Tyr Ser Phe Ala
                 245                 250                 255    
 Ser Gln Gln Gln Lys Pro Glu Asp Thr Thr Ile Pro Ser Thr Glu Leu
             260                 265                 270        
 Ala Lys Gln Val Ile Glu Tyr Ala Arg Gln Leu Glu Met Ile Val
         275                 280                 285        



      <210> 1036
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 1036
 Met Gly Thr Pro Ala Ser Val Val Ser Glu Pro Pro Pro Trp Gln Ala
   1               5                  10                  15    
 Pro Ile Glu Ala Arg Gly Arg Lys Gln Ala Ser Ala Asn Ile Phe Gln
              20                  25                  30        
 Asp Ala Glu Leu Leu Gln Ile Gln Ala Leu Phe Gln Arg Ser Gly Asp
          35                  40                  45            
 Gln Leu Ala Glu Glu Arg Ala Gln Ile Ile Trp Glu Cys Ala Gly Asp
      50                  55                  60                
 His Arg Val Ala Glu Ala Leu Lys Arg Leu Arg Arg Lys Arg Pro Pro
  65                  70                  75                  80
 Arg Gln Lys Pro Leu Gly His Ser Leu His His Cys Ser Arg Leu Arg
                  85                  90                  95    
 Ile Leu Glu Pro His Ser Ala Leu Ala Asn Pro Gln Ser Ala Thr Glu
             100                 105                 110        
 Thr Ala Ser Ser Glu Gln Tyr Leu His Ser Arg Lys Lys Ser Ala Arg
         115                 120                 125            
 Ile Arg Arg Asn Trp Arg Lys Ser Gly Pro Thr Ser Tyr Leu His Gln
     130                 135                 140                
 Ile Arg His
 145        



      <210> 1037
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 1037
 Met Ala Asp Val Arg Ala Gly Phe Leu Val Ile Ala Pro Ser Gly Ser
   1               5                  10                  15    
 Ser Cys Phe Ser Thr Leu Thr Leu Pro Val Arg Asp Asn Leu Leu Met
              20                  25                  30        
 His His Leu Lys Leu Ser Ser Arg Lys Lys Thr Pro Gly Met Arg Leu
          35                  40                  45            
 Gly Gln Arg Val Ser Arg Met Ala Pro Leu Pro Gly Ala Glu Leu Val
      50                  55                  60                
 Arg Arg Pro Leu Gln Leu Tyr Arg Tyr Leu Leu Arg Cys Cys Gln Gln
  65                  70                  75                  80
 Leu Pro Thr Lys Gly Ile Gln Gln His Tyr Lys His Ala Val Arg Gln
                  85                  90                  95    
 Ser Phe Arg Val His Ser Asp Glu Asp Asn Pro Glu Arg Ile Gln Gln
             100                 105                 110        
 Ile Ile Lys Arg Ala Ile Glu Asp Ala Asp Trp Ile Met Asn Lys Tyr
         115                 120                 125            
 Lys Lys Gln Asn
     130        



      <210> 1038
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 1038
 Met Val Pro Glu Ala Ala Arg Gly Lys Val Phe Gln Asp Ser Gln Glu
   1               5                  10                  15    
 Gly Ala His Ile Arg Arg Glu Thr Val Ser Lys Ser Val Cys Ala Glu
              20                  25                  30        
 Pro Trp Arg His Gln Arg Ala Arg Asp Pro Ala Pro Thr Asn Phe Pro
          35                  40                  45            
 Leu Lys Cys Gln Lys Gln Arg Gly Ala Ser Thr Ser Ser Gly Gln His
      50                  55                  60                
 Gly Gly Arg Val Asn Leu Val Phe Phe Ile Asp Asp Asp Tyr Ser Pro
  65                  70                  75                  80
 Pro Ser Lys Arg Gln Arg Pro Thr Ser His His Ser His Gln Ser Gln
                  85                  90                  95    
 Asn Leu Pro Met Leu Gly Asn Gly Lys
             100                 105



      <210> 1039
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 1039
 Met Glu Gly Lys Lys Leu Gln Leu Gly Ile Glu Glu Asp Leu Ala Glu
   1               5                  10                  15    
 Pro Ser Lys Ser Gln Thr Arg Lys Pro Lys Cys Gly Lys Gly Thr His
              20                  25                  30        
 Cys Ser Arg Asn Ala Tyr Met Leu Val Tyr Arg Leu Gln Thr Gln Glu
          35                  40                  45            
 Lys Pro Asn Thr Thr Val Gln Val Pro Ala Phe Leu Gln Glu Leu Val
      50                  55                  60                
 Asp Arg Asp Asn Ser Lys Phe Glu Glu Trp Cys Ile Glu Met Ala Glu
  65                  70                  75                  80
 Met Arg Lys Gln Ser Val Asp Lys Gly Lys Ala Lys His Glu Glu Val
                  85                  90                  95    
 Lys Glu Leu Tyr Gln Arg Leu Pro Ala Gly Ala Gly Leu
             100                 105                



      <210> 1040
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 1040
 Met Lys Thr Ser Asp Ile Lys Glu Leu Asn Ile Val Leu Pro Glu Phe
   1               5                  10                  15    
 Glu Lys Thr His Leu Glu His Gln Gln Arg Ile Glu Ser Lys Val Cys
              20                  25                  30        
 Lys Ala Ala Ile Ala Thr Phe Tyr Val Asn Val Lys Glu Gln Phe Ile
          35                  40                  45            
 Lys Met Leu Lys Glu Ser Gln Met Leu Thr Asn Leu Lys Arg Lys Asn
      50                  55                  60                
 Ala Lys Met Ile Ser Asp Ile Glu Lys Lys Arg Gln Arg Met Ile Glu
  65                  70                  75                  80
 Val Gln Asp Glu Leu Leu Arg Leu Glu Pro Gln Leu Lys Gln Leu Gln
                  85                  90                  95    
 Thr Lys Tyr Asp Glu Leu Lys Glu Arg Lys Ser Ser Leu Arg Asn Ala
             100                 105                 110        
 Ala Tyr Phe Leu Ser Asn Leu Lys Gln Leu Tyr Gln Asp Tyr Ser Asp
         115                 120                 125            
 Val Gln Ala Gln Glu Pro Asn Val Lys Glu Thr Tyr Asp Ser Ser Ser
     130                 135                 140                
 Leu Pro Ala Leu Leu Phe Lys Ala Arg Thr Leu Leu Gly Ala Glu Ser
 145                 150                 155                 160
 His Leu Arg Asn Ile Asn His Gln Leu Glu Lys Leu Leu Asp Gln Gly
                 165                 170                 175    





      <210> 1041
      <211> 228
      <212> PRT
      <213> Homo sapiens


      <400> 1041
 Met Pro Arg Arg Gly Leu Val Ala Gly Pro Asp Leu Glu Tyr Phe Gln
   1               5                  10                  15    
 Arg Arg Tyr Phe Thr Pro Ala Glu Val Ala Gln His Asn Arg Pro Glu
              20                  25                  30        
 Asp Leu Trp Val Ser Tyr Leu Gly Arg Val Tyr Asp Leu Thr Ser Leu
          35                  40                  45            
 Ala Gln Glu Tyr Lys Gly Asn Leu Leu Leu Lys Pro Ile Val Glu Val
      50                  55                  60                
 Ala Gly Gln Asp Ile Ser His Trp Phe Asp Pro Lys Thr Arg Asp Ile
  65                  70                  75                  80
 Arg Lys His Ile Asp Pro Leu Thr Gly Cys Leu Arg Tyr Cys Thr Pro
                  85                  90                  95    
 Arg Gly Arg Phe Val His Val Pro Pro Gln Leu Pro Cys Ser Asp Trp
             100                 105                 110        
 Ala Asn Asp Phe Gly Lys Pro Trp Trp Gln Gly Ser Tyr Tyr Glu Val
         115                 120                 125            
 Gly Arg Leu Ser Ala Lys Thr Arg Ser Ile Arg Ile Ile Asn Thr Leu
     130                 135                 140                
 Thr Ser Gln Glu His Thr Leu Glu Val Gly Val Leu Glu Ser Ile Trp
 145                 150                 155                 160
 Glu Ile Leu His Arg Tyr Leu Pro Tyr Asn Ser His Ala Ala Ser Tyr
                 165                 170                 175    
 Thr Trp Lys Tyr Glu Gly Lys Asn Leu Asn Met Asp Phe Thr Leu Glu
             180                 185                 190        
 Glu Asn Gly Ile Arg Asp Glu Glu Glu Glu Phe Asp Tyr Leu Ser Met
         195                 200                 205            
 Asp Gly Thr Leu His Thr Pro Ala Ile Leu Leu Tyr Phe Asn Asp Asp
     210                 215                 220                
 Leu Thr Glu Leu
 225            



      <210> 1042
      <211> 241
      <212> PRT
      <213> Homo sapiens


      <400> 1042
 Met Gln Val Gln Asp Arg Arg Ser Val Gly Gln Met Lys Phe Leu Ala
   1               5                  10                  15    
 Trp Thr Val Arg Gly Leu Ala Ala Ser Pro Leu Arg Ser Pro Ser Thr
              20                  25                  30        
 Cys Pro Gly Pro Ser Ser Trp Pro Val Gly Lys Leu Gly His Ala Gly
          35                  40                  45            
 Lys Ala Leu Cys Gly Ala Arg Gly Phe Ala Gly Glu His Cys Gly Tyr
      50                  55                  60                
 Thr Arg Leu Val Gly Val Gln Gly Val Pro Gly His Leu Gln Gly Val
  65                  70                  75                  80
 Glu Glu Arg Ala Leu Gly Gly Lys Ser Val Phe Gly Leu Thr Glu Gly
                  85                  90                  95    
 Arg Ser Trp Arg Ala Glu Gly Ser Arg Pro Ser Lys Ser Cys Trp Asp
             100                 105                 110        
 Gln Gly Asp Arg Met Arg Thr Arg Trp Glu Gln Val Val Pro Ser Pro
         115                 120                 125            
 His Lys Gln Phe Leu Leu Gly Pro Arg Ala Ser Leu Gly Ile Gln Gly
     130                 135                 140                
 Val Gly Trp Phe Cys His Ala Leu Gln Leu Glu Glu Thr Ser Gln Val
 145                 150                 155                 160
 Arg Arg Gly Pro Leu Leu His Ser His Arg His Val Thr Gly Leu Ser
                 165                 170                 175    
 Val Leu Pro Ser Gln Asp Asp Pro Ser Gly Glu Gly Val Leu Pro Ser
             180                 185                 190        
 Ala Arg Gly Pro Ala Thr Phe Leu Pro Phe Leu Thr Val Asp Leu Pro
         195                 200                 205            
 Val Tyr Val Leu Gln Glu Val Leu Pro Ser Ser Gly Gly Pro Ala Gly
     210                 215                 220                
 Pro Glu Ala Thr Gln Phe Pro Gly Ser Thr Ile Asn Leu Gln Asp Leu
 225                 230                 235                 240
 Gln
    



      <210> 1043
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 1043
 Met Gly Asn Ser Ile Asp Thr Val Arg Tyr Gly Lys Glu Ser Asp Leu
   1               5                  10                  15    
 Gly Asp Val Ser Glu Glu His Gly Glu Trp Asn Lys Glu Ser Ser Asn
              20                  25                  30        
 Asn Glu Gln Asp Asn Ser Leu Leu Glu Gln Tyr Leu Thr Ser Val Gln
          35                  40                  45            
 Gln Leu Glu Asp Ala Asp Glu Arg Thr Asn Phe Asp Thr Glu Thr Arg
      50                  55                  60                
 Asp Ser Lys Leu His Ile Ala Cys Phe Pro Val Gln Leu Asp Thr Leu
  65                  70                  75                  80
 Ser Asp Gly Ala Ser Val Asp Glu Ser His Gly Ile Ser Pro Pro Leu
                  85                  90                  95    
 Gln Gly Glu Ile Ser Gln Thr Gln Glu Asn Ser Lys Leu Asn Ala Glu
             100                 105                 110        
 Val Gln Gly Gln Gln Pro Glu Cys Asp Ser Thr Phe Gln Leu Leu His
         115                 120                 125            
 Val Gly Val Thr Val
     130            



      <210> 1044
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 1044
 Met Ala Phe Glu Ala Ile Val Lys Lys Gln Ile Val Lys Leu Lys Glu
   1               5                  10                  15    
 Pro Ser Leu Lys Cys Val Asp Leu Val Val Ser Glu Leu Ala Thr Val
              20                  25                  30        
 Ile Lys Lys Cys Ala Glu Lys Val Thr Gly Phe Val Leu Ile Ser Ala
          35                  40                  45            
 Phe Val Pro Val Leu Pro Leu His Val Leu Val Ser Thr Arg Ala Ser
      50                  55                  60                
 Gly Lys Phe Ser Leu Gly Arg Asn Pro Leu Pro Pro Thr Ser Cys His
  65                  70                  75                  80
 Leu Glu Met Ser Pro Pro Cys Ile Gly Arg Trp Asn Gly Gly Ser Gly
                  85                  90                  95    
 Ile Thr Arg Gly Leu Trp Leu Pro Val Gly Ala Val Ser Leu Cys Cys
             100                 105                 110        
 Cys Gln Thr His Cys Ile Tyr
         115                



      <210> 1045
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 1045
 Met Glu Gly Leu Arg Ser Ser Val Glu Leu Asp Pro Glu Leu Thr Pro
   1               5                  10                  15    
 Gly Lys Leu Asp Glu Glu Met Val Gly Leu Pro Pro His Asp Ala Ser
              20                  25                  30        
 Pro Gln Val Thr Phe His Ser Leu Asp Gly Lys Thr Val Val Cys Pro
          35                  40                  45            
 His Phe Met Gly Leu Leu Leu Gly Leu Leu Leu Leu Leu Thr Leu Ser
      50                  55                  60                
 Val Arg Asn Gln Leu Cys Val Arg Gly Glu Arg Gln Leu Ala Glu Thr
  65                  70                  75                  80
 Leu His Ser Gln Val Lys Glu Lys Ser Gln Leu Ile Gly Lys Lys Thr
                  85                  90                  95    
 Asp Cys Arg Asp
             100



      <210> 1046
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 1046
 Met Ala Val Ser Asn Pro Ala Ser Ser Leu Asn Pro Gly Thr Arg Pro
   1               5                  10                  15    
 Asn Pro Arg Lys Ser Thr Asn Pro Arg Met Asn Pro Asn Pro Gly Ile
              20                  25                  30        
 Ser Pro Asp Leu Lys Met Thr Ser Ser Pro Lys Met Thr Pro Asn Ser
          35                  40                  45            
 Lys Thr Ser Leu Asn Arg Ala Val Thr Pro Lys Ser His Asn Tyr Glu
      50                  55                  60                
 Tyr Glu Tyr Cys Asp Lys Trp
  65                  70    



      <210> 1047
      <211> 255
      <212> PRT
      <213> Homo sapiens


      <400> 1047
 Met Glu Val Leu Ala Lys Glu Asp Thr Glu Ala Ala Ile Gln Ser Ile
   1               5                  10                  15    
 Leu Tyr Lys Glu Asn Ser Val Ile Lys Glu Leu Asp Lys Tyr Leu Gln
              20                  25                  30        
 His His Ala Phe Leu Asn Ala Arg Arg Lys Glu Met Leu Tyr Lys Arg
          35                  40                  45            
 Trp Val Asp Cys Val Ala Asp Pro Leu Gln Lys Lys Ile Ile Glu Lys
      50                  55                  60                
 Val Cys Ser His Lys Lys Ile Lys Lys Arg Arg Gln Gly Glu Leu Asp
  65                  70                  75                  80
 Gly Phe Leu Lys His Val Asn Lys Lys Gly Asn Ala Phe Ile Glu His
                  85                  90                  95    
 Tyr Asp Pro Lys Glu Tyr Asp Pro Phe Tyr Met Ser Lys Lys Asp Pro
             100                 105                 110        
 Asn Phe Leu Lys Val Thr Ile Pro Pro Phe His Asp Pro Leu Lys Lys
         115                 120                 125            
 Ala Gln Tyr Asp Lys Asp Asn Glu Lys Arg Thr Leu Leu Gln Cys Glu
     130                 135                 140                
 Thr Gly Lys Ile Tyr Ser Ile Lys Glu Phe Lys Glu Val Glu Lys Val
 145                 150                 155                 160
 Gln Leu His Ser Arg Phe Pro Gln Ile Ser Asn Ser Arg His Phe Ile
                 165                 170                 175    
 Thr Pro Asn Glu Trp Leu Lys Leu Pro Thr Arg Tyr Ile Glu Ser Glu
             180                 185                 190        
 Phe Cys Arg Arg Arg Arg Asn Lys Gly Ser Ser Phe Leu Glu Arg Glu
         195                 200                 205            
 Pro Leu Cys Tyr Gln Glu Gly Asn Asn Pro Ser Ala Lys Glu Ala Ile
     210                 215                 220                
 Ser Glu Gly Tyr Phe Ser Ser Leu Ser Leu Ser Gln Glu Arg Glu Glu
 225                 230                 235                 240
 Asp Gln Asp Gly Phe Gln Gln Pro Arg Ser Thr His Pro Asp Pro
                 245                 250                 255



      <210> 1048
      <211> 75
      <212> PRT
      <213> Homo sapiens


      <400> 1048
 Met Cys Arg Leu Thr Trp Ala Val Gln Ala Gly Ala Val Val Gly His
   1               5                  10                  15    
 Ser Ser Asp Thr Glu Ile Met Ala Gln Gly Glu Ala Ser Thr Met Gln
              20                  25                  30        
 Asp Gly Trp Pro Gly Val Ala Val Ala Gly His Asp Gly Leu Ala Ala
          35                  40                  45            
 Gly Leu His Gly Leu Ala Gln Ala Val Gly Gly Val Asp Asp Pro Leu
      50                  55                  60                
 Gly Glu Arg Val Gly Gly Cys Thr Ala Thr Gly
  65                  70                  75



      <210> 1049
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 1049
 Met Gln Arg Ile Ile Lys Asn Asn Glu Val Val Asp Glu Thr Trp His
   1               5                  10                  15    
 Leu Leu Pro Lys Asp Ala Ser Phe Asp Gly Ile Ser Asn Cys Asp Asp
              20                  25                  30        
 Leu Ile Val Pro Leu Ala Leu Trp Arg Glu His Ala His Ala Leu Lys
          35                  40                  45            
 Ala Arg Asp Gly Gly Leu Gly Val Trp Leu Asp Ala Asp Glu Glu Ala
      50                  55                  60                
 Glu Glu Ile Gly Glu Asp Val Glu His Phe Gln Val Ile Ala Leu Asn
  65                  70                  75                  80
 Phe Pro Ala Phe Thr Asp Gly Arg Asn Tyr Ser Asn Ala Arg Leu Leu
                  85                  90                  95    
 Arg Asp Arg Tyr Gly Tyr Lys Gly Glu Leu Arg Ala Ile Gly Asp Val
             100                 105                 110        
 Leu Arg Asp Gln Leu Phe Tyr Leu Arg Arg Cys Gly Phe Asp Ala Phe
         115                 120                 125            
 Ala Leu Arg Ala Asp Lys Asp Pro Tyr Glu Ala Leu Glu Ser Leu Lys
     130                 135                 140                
 Asp Phe Ser Val Thr Tyr Gln Ala Ala Thr Asp Glu Pro Leu Pro Leu
 145                 150                 155                 160
 Phe Arg Arg Arg
                



      <210> 1050
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 1050
 Met Gly Gly Thr Lys Arg Gly Ile Lys Lys Leu Val Asn Val Cys Leu
   1               5                  10                  15    
 Lys His Pro Lys Asn Thr Ser Leu Ser Gln Gln Leu Val Phe Ala Lys
              20                  25                  30        
 Ile Asn Lys Ile Leu Ile Ser Lys Thr Thr Lys Ser Thr Asn Leu Lys
          35                  40                  45            
 Gly Leu Lys Cys Leu Pro Pro Leu Ser Val Ser Ile His Pro Thr Phe
      50                  55                  60                
 Ile Tyr Tyr Lys His Asn Thr Thr Leu Arg Ile Val Phe Gly Thr Tyr
  65                  70                  75                  80
 Phe Asp Phe Phe Pro Tyr Arg Lys Asn Lys Asp Gln Ala Phe Glu Gly
                  85                  90                  95    
 Glu Asp Trp Glu Ser Ser Leu Asn Val Tyr Ile Gln Asn Tyr Ile Ile
             100                 105                 110        
 Phe Ala His Ser Val Asp Phe Leu Lys Phe Lys Asn Thr Tyr Thr Lys
         115                 120                 125            
 Ser Thr Tyr Gly Ile His Ile Leu Thr Ala
     130                 135            



      <210> 1051
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 1051
 Met Ala His Leu Lys Asp Ser Glu Gly Met Gly Arg Thr Lys Phe Leu
   1               5                  10                  15    
 Ser Ile Gln Asp Glu Phe Cys His Phe Leu Gln Met Thr Gly Gln Lys
              20                  25                  30        
 Glu Arg Ala Thr Ser Ile Leu Arg Glu Ser Leu Glu Ala Lys Val Glu
          35                  40                  45            
 Ala Phe Gly Asp Phe Ser Pro Glu Val Ala Glu Thr Tyr Arg Leu Leu
      50                  55                  60                
 Gly Gly Ala Asp Leu Ala Gln Gly Asn His Ser Gly Ala Arg Lys Lys
  65                  70                  75                  80
 Leu Lys Lys Cys Leu Gln Ile Gln Thr Leu Leu Tyr Gly Pro Gln Asp
                  85                  90                  95    
 Lys Arg Thr Leu Ala Thr Gln Gln Ala Met Gly Met Leu Ser Thr Ala
             100                 105                 110        
 Pro Lys Val Ala Ser Lys Pro Arg Gln Ala Ser Lys Ala Lys Val Ala
         115                 120                 125            
 Phe Cys Thr Ser Ile Pro Gln Asp Thr Leu Leu Gly Lys Ala Arg Pro
     130                 135                 140                
 Gly Thr Thr Ala Asp
 145                



      <210> 1052
      <211> 26
      <212> PRT
      <213> Homo sapiens


      <400> 1052
 Met Gln Asp Gly Ser Val Asn Leu Phe Thr Thr Arg Glu His Tyr Lys
   1               5                  10                  15    
 Ala Pro Gln Val Gly Arg Gly Arg Lys Glu
              20                  25    


